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Gis tumor

Pei-Chen Lee, Ole Raaschou-Nielsen, Christina M Lill, Lars Bertram, Janet S Sinsheimer, Johnni Hansen, Beate Ritz
Both air pollution exposure and systemic inflammation have been linked to Parkinson's disease (PD). In the PASIDA study, 408 incident cases of PD diagnosed in 2006-2009 and their 495 population controls were interviewed and provided DNA samples. Markers of long term traffic related air pollution measures were derived from geographic information systems (GIS)-based modeling. Furthermore, we genotyped functional polymorphisms in genes encoding proinflammatory cytokines, namely rs1800629 in TNFα (tumor necrosis factor alpha) and rs16944 in IL1B (interleukin-1β)...
September 15, 2016: Environmental Research
Xufeng Fei, Zhaohan Lou, George Christakos, Qingmin Liu, Yanjun Ren, Jiaping Wu
BACKGROUND: Breast cancer (BC) is the most common female malignant tumor. Previous studies have suggested a big incidence disparity among different cities in China. The present work selected a typical city, Hangzhou, to study BC incidence disparity within the city. METHODS: Totally, 8784 female breast cancer cases were obtained from the Hangzhou Center for Disease Control and Prevention during the period 2008-2012. Analysis of Variance and Poisson Regression were the statistical tools implemented to compare incidence disparity in the space-time domain (reference group: township residents during 2008, area: subdistrict, town, and township, time frame: 2008-2012), space-time scan statistics was employed to detect significant spatiotemporal clusters of BC compared to the null hypothesis that the probability of cases diagnosed at a particular location was equal to the probability of cases diagnosed in the whole study area...
2016: PloS One
Neel S Madhukar, Olivier Elemento, Gaurav Pandey
A genetic interaction (GI) is a type of interaction where the effect of one gene is modified by the effect of one or several other genes. These interactions are important for delineating functional relationships among genes and their corresponding proteins, as well as elucidating complex biological processes and diseases. An important type of GI - synthetic sickness or synthetic lethality - involves two or more genes, where the loss of either gene alone has little impact on cell viability, but the combined loss of all genes leads to a severe decrease in fitness (sickness) or cell death (lethality)...
2015: Frontiers in Bioengineering and Biotechnology
Mingyan He, Rong Zhang, Fengyi Zhai, Lisha Zhou, Meng Wang, Mengjie Jiang, Ziping Li, Shiting Feng
OBJECTIVE: To compare the CT image of gastrointestinal schwannomas (GIS) and gastrointestinal stromal tumors(GIST), and to find the CT features to be helpful for differentiation of GIS from GIST. METHODS: Clinical and iconography data of 15 GIS patients and 50 GIST patients who underwent stomach CT scan with postoperatively confirmed histopathology between January 2000 and July 2014 in our department were collected retrospectively. CT findings of these two tumors were compared...
October 2015: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
John P Hanley, Erin Jackson, Leslie A Morrissey, Donna M Rizzo, Brian L Sprague, Indra Neil Sarkar, Frances E Carr
BACKGROUND: The increasing incidence of thyroid cancer has resulted in the rate tripling over the past 30 years. Reasons for this increase have not been established. Geostatistics and geographic information system (GIS) tools have emerged as powerful geospatial technologies to identify disease clusters, map patterns and trends, and assess the impact of ecological and socioeconomic factors (SES) on the spatial distribution of diseases. In this study, these tools were used to analyze thyroid cancer incidence in a rural population...
July 2015: Thyroid: Official Journal of the American Thyroid Association
Erdal Polat, Erdal Birol Bostanci, Erol Aksoy, Kerem Karaman, Nilufer Yildirim Poyraz, Ugur Duman, Zeynep Biyikli Gencturk, Sinan Yol
PURPOSE: To investigate the efficacy of positron emission tomography/computed tomography (PET/CT) in detection and management of hepatic and extrahepatic metastases from gastrointestinal cancers. MATERIALS AND METHODS: Between February 2008 and July 2010, patients histopathologically diagnosed with gastrointestinal cancer and showing suspected metastasis on CT screening were subsequently evaluated with PET/CT. All patients were subgrouped according to histopathological origin and localization of the primary tumor...
June 2015: European Journal of Radiology
Daniela Viramontes-Hörner, Fabiola Márquez-Sandoval, Fabiola Martín-del-Campo, Barbara Vizmanos-Lamotte, Ana Sandoval-Rodríguez, Juan Armendáriz-Borunda, Héctor García-Bejarano, Karina Renoirte-López, Guillermo García-García
OBJECTIVE: The study aimed to assess the effect of a symbiotic gel on presence and severity of gastrointestinal symptoms (GIS) in hemodialysis patients. DESIGN: A double-blinded, placebo-controlled, randomized, clinical trial was designed. The study was conducted at 2 public hospitals in Guadalajara, Mexico. SUBJECTS AND INTERVENTION: Twenty-two patients were randomized to the intervention group (nutritional counseling + symbiotic gel) and 20 patients were randomized to the control group (nutritional counseling + placebo), during 2 months of follow-up...
May 2015: Journal of Renal Nutrition
Changji Xiao, Jing Zhao, Mengtao Li, Dachun Zhao, Yang Xiang
•An improved YASSO model is proposed by considering residual spatial autocorrelation.•Model prediction errors are minimised using GIS data at the appropriate spatial scale.•Topographical factors describe 24-49% of variation in soil carbon.
August 2014: Gynecologic Oncology Case Reports
Naoki Takemura, Takumi Kawasaki, Jun Kunisawa, Shintaro Sato, Aayam Lamichhane, Kouji Kobiyama, Taiki Aoshi, Junichi Ito, Kenji Mizuguchi, Thangaraj Karuppuchamy, Kouta Matsunaga, Shoichiro Miyatake, Nobuko Mori, Tohru Tsujimura, Takashi Satoh, Yutaro Kumagai, Taro Kawai, Daron M Standley, Ken J Ishii, Hiroshi Kiyono, Shizuo Akira, Satoshi Uematsu
High-dose ionizing radiation induces severe DNA damage in the epithelial stem cells in small intestinal crypts and causes gastrointestinal syndrome (GIS). Although the tumour suppressor p53 is a primary factor inducing death of crypt cells with DNA damage, its essential role in maintaining genome stability means inhibiting p53 to prevent GIS is not a viable strategy. Here we show that the innate immune receptor Toll-like receptor 3 (TLR3) is critical for the pathogenesis of GIS. Tlr3(-/-) mice show substantial resistance to GIS owing to significantly reduced radiation-induced crypt cell death...
2014: Nature Communications
Luciana Ansaneli Naves, Lara Benigno Porto, João Willy Corrêa Rosa, Luiz Augusto Casulari, José Wilson Corrêa Rosa
Geographical information systems (GIS) have emerged as a group of innovative software components useful for projects in epidemiology and planning in Health Care System. This is an original study to investigate environmental and geographical influences on epidemiology of acromegaly in Brazil. We aimed to validate a method to link an acromegaly registry with a GIS mapping program, to describe the spatial distribution of patients, to identify disease clusters and to evaluate if the access to Health Care could influence the outcome of the disease...
February 2015: Pituitary
Nataliya Razumilava, Sergio A Gradilone, Rory L Smoot, Joachim C Mertens, Steven F Bronk, Alphonse E Sirica, Gregory J Gores
BACKGROUND & AIMS: The Hedgehog signaling pathway contributes to cholangiocarcinoma biology. However, canonical Hedgehog signaling requires cilia, and cholangiocarcinoma cells often do not express cilia. To resolve this paradox, we examined non-canonical (G-protein coupled, pertussis toxin sensitive) Hedgehog signaling in cholangiocarcinoma cells. METHODS: Human [non-malignant (H69), malignant (HuCC-T1 and Mz-ChA-1)] and rat [non-malignant (BDE1 and NRC), and malignant (BDEneu)] cell lines were employed for this study...
March 2014: Journal of Hepatology
Michael C Bassik, Martin Kampmann, Robert Jan Lebbink, Shuyi Wang, Marco Y Hein, Ina Poser, Jimena Weibezahn, Max A Horlbeck, Siyuan Chen, Matthias Mann, Anthony A Hyman, Emily M Leproust, Michael T McManus, Jonathan S Weissman
Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the systematic exploration of gene function in microorganisms. Here, we present a two-stage strategy to construct high-density GI maps in mammalian cells. First, we use ultracomplex pooled shRNA libraries (25 shRNAs/gene) to identify high-confidence hit genes for a given phenotype and effective shRNAs. We then construct double-shRNA libraries from these to systematically measure GIs between hits...
February 14, 2013: Cell
F M Elebead, Amna Hamid, H S M Hilmi, H Galal
In Sudan, the prevalence of cancer cases increased and cancer ranked as the major cause of death. Therefore, forming a cancer control program and putting strategic action plans into practice became an important matter for the health industry. The correlation of variations in different societies and environmental factors should be examined spatially with reliable data. The aim of this study is to produce base maps for implementation of cancer control program and cancer density maps through the utilization of GIS in health work...
August 2012: Journal of Community Health
Jesse Lachter, Yoav Rosenthal, Yoram Kluger
BACKGROUND: EUS-guided FNA can help diagnose and differentiate between various pancreatic and other lesions.The aim of this study was to compare approaches among involved/relevant physicians to the controversies surrounding the use of FNA in EUS. METHODS: A five-case survey was developed, piloted, and validated. It was collected from a total of 101 physicians, who were all either gastroenterologists (GIs), surgeons or oncologists. The survey compared the management strategies chosen by members of these relevant disciplines regarding EUS-guided FNA...
2011: BMC Gastroenterology
Daisuke Fukumori, Tadashi Matsuhisa, Kouichi Taguchi, Masaoki Minato
It is very rare for ectopic pancreas to become cancerous. We herein report on a case of ectopic pancreatic cancer developed in the stomach. A neoplastic lesion was detected in the pyloric part in an upper GIS of a 76-year-old female, requiring biopsy, but because it was classified as Group I, it was observed temporarily. Following blood collection after approximately 2 years, the CA19-9 increased from 177.5 to 279.5, so a GIS was again performed. Although the pyloric part of the stomach became more stenosed than before, it was still considered Group I disease based on biopsy findings...
May 2011: Hepato-gastroenterology
M Rami Bailony, Mohammad K Hararah, Abdel Razzaq Salhab, Ibrahim Ghannam, Ziad Abdeen, Jess Ghannam
In low and middle income countries (LMIC), high-quality disease registration is difficult to achieve in the setting of inadequate healthcare infrastructure and political or economical instability. In this article, we explore the potential of geographic information systems (GIS) to add value to the understanding of childhood cancer patterns in the West Bank, despite a variety of obstacles to disease registration. All incidence cases of childhood cancers (under the age 15) from 1998 to 2007 were collected from the West Bank Cancer Registry...
September 1, 2011: International Journal of Cancer. Journal International du Cancer
Ruth Vrolix, Ronald P Mensink
BACKGROUND: Epidemiologic studies suggest that diets with a low glycemic index (GI) or glycemic load (GL) are associated with a decreased risk of developing metabolic syndrome. Intervention studies are inconsistent, however, possibly due to differences in macronutrient and fiber compositions of the experimental diets. OBJECTIVE: We tested side-by-side test foods with similar macronutrient and fiber compositions but with different sucrose-flour ratios or carbohydrate source to determine the effects of different GIs and GLs on metabolic risk markers in overweight subjects...
August 2010: American Journal of Clinical Nutrition
Linda M Woodward
BACKGROUND: Gastrointestinal stromal (GIS) tumors are rare malignancies that affect the esophagus, stomach, gallbladder, liver, small intestine, colon, or rectum. These tumors are often refractory to treatment with radiotherapy and chemotherapy and usually treated with a combination of surgery and imatinib mesylate, a tyrosine kinase inhibitor. CASE: This case study describes the management of an enterocutaneous fistula in a patient with a rare GIS tumor who ultimately required radical excision of the mesenteric GIS tumor by enteroenterostomy and colocolostomy...
May 2010: Journal of Wound, Ostomy, and Continence Nursing
Adnan Yoney, Bulent Askaroglu, Tayfun Hancilar, Levent Isikli, Mustafa Unsal
BACKGROUND: 5-fluorouracil (FU) is commonly used in preoperative chemoradiation in locally advanced rectal cancer, but not all patients cooperate in taking the 5-day continuous infusion regimen. Raltitrexed (RA), a thymidylate synthase inhibitor, is one of the agents used in place of FU in such cases. We retrospectively compared the toxicity, tumor downstaging, pathologic response and relapse rate with bolus FU or RA during concurrent radiotherapy (RT) to assess the role of RA in place of FU...
January 2008: Hematology/oncology and Stem Cell Therapy
Taro Aoki, Yuko Igarashi, Keiko Tanizaki, Chihiro Yamanaka, Tsukasa Tanida, Takamichi Komori, Takashi Matsumoto, Kiyonori Nishioka, Ko Takachi, Yoshio Uemura, Kenji Kobayashi
A patient is a 62-year-old man who was presented by epigastralgia. He was pointed out super advanced gastric cancer with paraaortic lymph node metastasis and pancreatic invasion by gastrointestinal endoscopy (GIS) and computed tomography (CT). We diagnosed as cT4N3M0, and started with chemotherapy as follows. S-1 (120 mg/day) was orally administered for 3 weeks followed by 2-week rest as one course, and CDDP (90 mg/body)was administered by intravenous drip on day 8. Partial response was indicated after 6 courses of this procedure...
November 2009: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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