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https://www.readbyqxmd.com/read/29160139/high-and-rising-burden-of-hip-and-knee-osteoarthritis-in-the-nordic-region-1990-2015
#1
Aliasghar A Kiadaliri, L Stefan Lohmander, Maziar Moradi-Lakeh, Ingemar F Petersson, Martin Englund
Background and purpose - Osteoarthritis (OA) imposes a substantial burden on individuals and societies. We report on the burden of knee and hip OA in the Nordic region. Patients and methods - We used the findings from the 2015 Global Burden of Diseases Study to explore prevalence, years lived with disability (YLDs), and disability-adjusted life-years (DALYs) of OA in the 6 Nordic countries during 1990-2015 (population of about 27 million in 2015). Results - During 1990-2015, the number of prevalent OA cases increased by 43% to 1,507,587 (95% uncertainty interval [UI] 1,454,338-1,564,778) in the region...
November 21, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/29160079/a-comprehensive-mass-spectrometric-survey-of-streptococcus-pyogenes-subcellular-proteomes
#2
Laura Wilk, Lotta Happonen, Johan Malmström, Heiko Herwald
Streptococcus pyogenes is a major global health burden causing a wide variety of diseases. As a vaccine against this bacterium is still lacking, vaccine candidates or antimicrobial therapies are urgently needed. Here, we use an invasive and clinical relevant streptococcal M1 serotype in order to characterise the bacterial proteome in-depth. An elaborate fractionation technique is employed to separate the different cell fractions followed by shotgun mass spectrometry analysis, allowing us to confirm the expression of nearly two thirds (1022) of the 1690 open reading frames predicted for the streptococcal M1 reference proteome...
November 21, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29159707/propionyl-coa-carboxylase-pcca-1-and-pccb-1-gene-deletions-in-caenorhabditis-elegans-globally-impair-mitochondrial-energy-metabolism
#3
Kimberly A Chapman, Julian Ostrovsky, Meera Rao, Stephen D Dingley, Erzsebet Polyak, Marc Yudkoff, Rui Xiao, Michael J Bennett, Marni J Falk
Propionic acidemia (PA) is a classical inborn error of metabolism with high morbidity that results from the inability of the propionyl-CoA carboxylase (PCC) enzyme to convert propionyl-CoA to methylmalonyl-CoA. PA is inherited in an autosomal recessive fashion due to functional loss of both alleles of either PCCA or PCCB. These genes are highly conserved across evolutionarily diverse species and share extensive similarity with pcca-1 and pccb-1 in the nematode, Caenorhabditis elegans. Here, we report the global metabolic effects of deletion in a single PCC gene, either pcca-1 or pccb-1, in C...
November 20, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29157312/combating-echinococcosis-in-china-strengthening-the-research-and-development
#4
Men-Bao Qian, Bernadette Abela-Ridder, Wei-Ping Wu, Xiao-Nong Zhou
Echinococcosis is a neglected zoonotic disease, causing great morbidity and mortality due to the wide distribution of its endemic areas. China holds a high percentage in the global burden of both cystic and alveolar echinococcosis. A national survey conducted between 2012 and 2016 showed that an estimated 50 million people are at risk of contracting the disease in western China, of whom about 0.17 million are cases with echinococcosis.Despite this, research and development on echinococcosis in China is greatly inadequate compared to that in other countries...
November 21, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29155673/strengthening-global-surveillance-for-antimicrobial-drug-resistant-neisseria-gonorrhoeae-through-the-enhanced-gonococcal-antimicrobial-surveillance-program
#5
Emily J Weston, Teodora Wi, John Papp
Monitoring trends in antimicrobial drug-resistant Neisseria gonorrhoeae is a critical public health and global health security activity because the number of antimicrobial drugs available to treat gonorrhea effectively is rapidly diminishing. Current global surveillance methods for antimicrobial drug-resistant N. gonorrhoeae have many limitations, especially in countries with the greatest burden of disease. The Enhanced Gonococcal Antimicrobial Surveillance Program is a collaboration between the World Health Organization and the Centers for Disease Control and Prevention...
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155670/lessons-learned-from-emergency-response-vaccination-efforts-for-cholera-typhoid-yellow-fever-and-ebola
#6
Jenny A Walldorf, Kashmira A Date, Nandini Sreenivasan, Jennifer B Harris, Terri B Hyde
Countries must be prepared to respond to public health threats associated with emergencies, such as natural disasters, sociopolitical conflicts, or uncontrolled disease outbreaks. Rapid vaccination of populations vulnerable to epidemic-prone vaccine-preventable diseases is a major component of emergency response. Emergency vaccination planning presents challenges, including how to predict resource needs, expand vaccine availability during global shortages, and address regulatory barriers to deliver new products...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155655/synergies-between-communicable-and-noncommunicable-disease-programs-to-enhance-global-health-security
#7
Deliana Kostova, Muhammad J Husain, David Sugerman, Yuling Hong, Mona Saraiya, Jennifer Keltz, Samira Asma
Noncommunicable diseases are the leading cause of death and disability worldwide. Initiatives that advance the prevention and control of noncommunicable diseases support the goals of global health security in several ways. First, in addressing health needs that typically require long-term care, these programs can strengthen health delivery and health monitoring systems, which can serve as necessary platforms for emergency preparedness in low-resource environments. Second, by improving population health, the programs might help to reduce susceptibility to infectious outbreaks...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155498/global-impact-of-nephropathies
#8
REVIEW
Philip Kam-Tao Li, Terry King-Wing Ma
The global burden of chronic kidney disease (CKD) has increased substantially in recent years, partly attributed to the global epidemic of diabetes mellitus. In many countries including China, glomerulonephritis was the most common cause of end stage renal disease (ESRD). The mortality rate of dialysis patients can be as high as patients with colon, breast and prostate cancers. CKD has important socio-economic impact on the healthcare system and society. Increasing awareness and early detection of CKD cannot be overemphasized...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29154750/global-perspectives-on-ensuring-the-safety-of%C3%A2-pharmaceutical-products-in-the-distribution-process%C3%A2
#9
Sohyun Jeong, Eunhee Ji
OBJECTIVE: The distribution of counterfeit or falsified drugs is increasing worldwide. This can contribute to the high burden of disease and cost to society and is of global concern with the worldwide circulation of pharmaceuticals. The preparation and implementation of good distribution practice should be one of the most important aspects of ensuring safe drug circulation and administration. This research aimed to compare and analyze good distribution practice guidelines from advanced countries and international organizations, and to evaluate the status of the current good distribution practice guidelines in the world...
November 20, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29154722/association-of-kidney-function-and-waist-circumference-with-uric-acid-levels-in-south-africans
#10
Nomandla Daphne Madala, Thozama Dubula, Alain Guy Honoré Assounga, Saraladevi Naicker
BACKGROUND: Recent evidence that hyperuricemia is associated with incident chronic kidney disease (CKD) provides a potential therapeutic target for CKD that has not been explored in Africans. With hyperuricemia and gout increasing globally, we sought to determine their prevalence in South Africans with varying kidney function levels. METHODS: This was a cross-sectional study of ambulatory adult patients presenting at a General Internal Medicine Outpatients Clinic between September 2012 and March 2014...
November 20, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29154226/short-term-exposures-to-pm2-5-and-cause-specific-mortality-of-cardiovascular-health-in-china
#11
Chen Chen, Pengfei Zhu, Li Lan, Lian Zhou, Ruicong Liu, Qinghua Sun, Jie Ban, Wentao Wang, Dandan Xu, Tiantian Li
BACKGROUND: Many multi-center epidemiological studies have robustly examined the acute health effects of exposure to low concentrations of fine particulate matter (PM2.5) on cardiovascular mortality in developed counties. However, data limitations have resulted in few related studies being conducted in developing counties with high levels of PM2.5 exposure. In recent years, people in China with a heavy cardiovascular disease burden have been exposed to particularly high levels of PM2...
November 16, 2017: Environmental Research
https://www.readbyqxmd.com/read/29152426/an-overview-of-infant-mortality-trends-in-qatar-from-2004-to-2014
#12
Mohammed Al-Thani, Al-Anoud Al-Thani, Amine Toumi, Shams Eldin Khalifa, Hammad Akram
Background Infant mortality is an important health indicator that estimates population well-being. Infant mortality has declined globally but is still a major public health challenge. This article provides the characteristics, causes, burden, and trends of infant mortality in Qatar. Methods Frequencies, percentages, and rates were calculated using data from birth-death registries over 2004-2014 to describe infant mortality by nationality, gender, and age group. We calculated the relative risks of the top causes of infant mortality among subgroups according to the 10(th) Revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10, Version 2016)...
September 9, 2017: Curēus
https://www.readbyqxmd.com/read/29150718/re-educating-immunity-in-respiratory-allergies-the-potential-for-hematopoietic-stem-cell-mediated-gene-therapy
#13
REVIEW
Jeremy F Brooks, Janet M Davies, James W Wells, Raymond J Steptoe
Respiratory allergies represent a significant disease burden worldwide affecting up to 300 million people globally. Medication and avoidance of known triggers do not address the underlying pathology. Traditional immunotherapies for allergy aim to reinstate immune homeostasis but require years of treatment and have poor long-term efficacy. Novel approaches, such as gene-engineered hematopoietic stem cell transplantation, induce profound antigen-specific tolerance in autoimmunity. Recent evidence shows this approach may also have therapeutic utility for allergy...
November 17, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29150201/nations-within-a-nation-variations-in-epidemiological-transition-across-the-states-of-india-1990-2016-in-the-global-burden-of-disease-study
#14
(no author information available yet)
BACKGROUND: 18% of the world's population lives in India, and many states of India have populations similar to those of large countries. Action to effectively improve population health in India requires availability of reliable and comprehensive state-level estimates of disease burden and risk factors over time. Such comprehensive estimates have not been available so far for all major diseases and risk factors. Thus, we aimed to estimate the disease burden and risk factors in every state of India as part of the Global Burden of Disease (GBD) Study 2016...
November 13, 2017: Lancet
https://www.readbyqxmd.com/read/29147893/high-elective-surgery-cancellation-rate-in-malawi-primarily-due-to-infrastructural-limitations
#15
Meghan Prin, Jessica Eaton, Onias Mtalimanja, Anthony Charles
BACKGROUND: The provision of safe and timely surgical care is essential to global health care. Low- and middle-income countries have a disproportionate share of the global surgical disease burden and struggle to provide care with the given resources. Surgery cancellation worldwide occurs for many reasons, which are likely to differ between high-income and low-income settings. We sought to evaluate the proportion of elective surgery that is cancelled and the associated reasons for cancellation at a tertiary hospital in Malawi...
November 16, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29146711/ethics-health-policy-and-zika-from-emergency-to-global-epidemic
#16
Euzebiusz Jamrozik, Michael J Selgelid
Zika virus was recognised in 2016 as an important vector-borne cause of congenital malformations and Guillain-Barré syndrome, during a major epidemic in Latin America, centred in Northeastern Brazil. The WHO and Pan American Health Organisation (PAHO), with partner agencies, initiated a coordinated global response including public health intervention and urgent scientific research, as well as ethical analysis as a vital element of policy design. In this paper, we summarise the major ethical issues raised during the Zika epidemic, highlighting the PAHO ethics guidance and the role of ethics in emergency responses, before turning to ethical issues that are yet to be resolved...
November 16, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29146639/impact-of-informal-caregiving-on-older-adults-physical-and-mental-health-in-low-income-and-middle-income-countries-a-cross-sectional-secondary-analysis-based-on-the-who-s-study-on-global-ageing-and-adult-health-sage
#17
Sylvie D Lambert, Steven J Bowe, Patricia M Livingston, Leila Heckel, Selina Cook, Paul Kowal, Liliana Orellana
OBJECTIVES: A high proportion of care stemming from chronic disease or disability in low-income and middle-income countries is provided by informal caregivers. The goal of this study was to determine the level of burden experienced by these caregivers, explore associated factors and assess whether caregivers' and non-caregivers' health differed. DESIGN AND SETTING: This cross-sectional study was a secondary analysis of data on caregivers' burden, health and health risk factors in Ghana, India and the Russian Federation collected as part of the WHO's Study on global AGEing and adult health (SAGE) Wave 1...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146122/health-and-wellbeing-of-indigenous-adolescents-in-australia-a-systematic-synthesis-of-population-data
#18
Peter S Azzopardi, Susan M Sawyer, John B Carlin, Louisa Degenhardt, Ngiare Brown, Alex D Brown, George C Patton
BACKGROUND: Indigenous populations have high rates of disease and premature mortality. Most Indigenous communities are young, and adolescence (age 10-24 years) provides great opportunities for population health gain. However, the absence of a comprehensive account of Indigenous adolescents' health has been a barrier to effective policy. We aimed to report a national health profile for Indigenous adolescents in Australia. METHODS: We undertook a systematic synthesis of population data to report the health and wellbeing of Indigenous adolescents in Australia...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29144534/building-and-strengthening-capacity-for-cardiovascular-research-in-africa-through-technical-training-workshops-a-report-of-the-joint-course-on-health-research-methods-by-the-clinical-research-education-networking-and-consultancy-and-the-ivorian-society-of-cardiology
#19
Bonaventure Suiru Dzekem, Jean Baptiste Kacou, Martin Abanda, Euloge Kramoh, Yves Yapobi, Samuel Kingue, Andre Pascal Kengne, Anastase Dzudie
Africa bears a quarter of the global burden of disease but contributes less than 2% of the global research publications on health, partially due to a lack of expertise and skills to carry out scientific research. We report on a short course on research methods organised by the Clinical Research Education Networking and Consultancy (CRENC) during the third international congress of the Ivorian Cardiac Society (SICARD) in Abidjan, Cote d'Ivoire. Results from the pre- and post-test evaluation during this course showed that African researchers could contribute more to scientific research and publications, provided adequate support and investment is geared towards the identification and training of motivated early-career scientists...
September 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29143676/the-future-of-viral-hepatitis-testing-innovations-in-testing-technologies-and-approaches
#20
REVIEW
Rosanna W Peeling, Debrah I Boeras, Francesco Marinucci, Philippa Easterbrook
A large burden of undiagnosed hepatitis virus cases remains globally. Despite the 257 million people living with chronic hepatitis B virus infection, and 71 million with chronic viraemic HCV infection, most people with hepatitis remain unaware of their infection. Advances in rapid detection technology have created new opportunities for enhancing access to testing and care, as well as monitoring of treatment. This article examines a range of other technological innovations that can be leveraged to provide more affordable and simplified approaches to testing for HBV and HCV infection and monitoring of treatment response...
November 1, 2017: BMC Infectious Diseases
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