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Infectious Diseases Society of America

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https://www.readbyqxmd.com/read/29781552/topical-rifampin-powder-for-orthopaedic-trauma-part-i-rifampin-powder-reduces-recalcitrant-infection-in-a-delayed-treatment-musculoskeletal-trauma-model
#1
Stefanie M Shiels, David J Tennent, Joseph C Wenke
Open fractures become infected despite meticulous debridement and care. Locally applied antibiotics, commonly embedded in polymethylmethacrylate, deliver high doses of drug directly to the fracture site. Direct application of antibiotic powder, which is being applied prophylactically in spine surgery, is a recent interest in the trauma sector, where bacterial biofilms are more prevalent. Traditional antibiotics, such as vancomycin, are poor performers against bacterial biofilms thus are ineffective in delayed treatment...
May 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29780851/top-questions-in-uncomplicated-non-staphylococcus-aureus-bacteremia
#2
Jesse D Sutton, Sena Sayood, Emily S Spivak
The Infectious Diseases Society of America infection-specific guidelines provide limited guidance on the management of focal infections complicated by secondary bacteremias. We address the following 3 commonly encountered questions and management considerations regarding uncomplicated bacteremia not due to Staphylococcus aureus : the role and choice of oral antibiotics focusing on oral beta-lactams, the shortest effective duration of therapy, and the role of repeat blood cultures.
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29779827/zika-virus-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#3
Gisele Sampaio Silva, Guy A Richards, Tim Baker, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Pravin Amin
Zika fever is an acute infectious disease caused by the Zika virus (ZIKV), an RNA virus belonging to the genus Flavivirus. ZIKV can be transmitted by bites from Aedes aegypti and Aedes albopictus species, sexual activity, blood transfusion and from mother to fetus during pregnancy and delivery. A total of 50 territories and countries in the Americas had reported ZIKV infections. For those with symptoms, the presentation is similar to dengue fever with body aches, joint pain, fatigue, malaise, fever and conjunctivitis lasting up to seven days...
April 5, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29773899/management-of-acute-hcv-infection-in-the-era-of-direct-acting-antiviral-therapy
#4
REVIEW
Marianne Martinello, Behzad Hajarizadeh, Jason Grebely, Gregory J Dore, Gail V Matthews
The management of acute HCV infection has not been standardized following the availability of direct-acting antiviral agents (DAAs) for chronic HCV infection, and substantial uncertainty exists regarding the optimal treatment regimen and duration. Despite the lack of direct evidence, the 2016 American Association for the Study of Liver Diseases (AASLD)-Infectious Diseases Society of America (IDSA) guidelines supported "the same regimens for acute HCV as recommended for chronic HCV infection … owing to high efficacy and safety", whereas the 2016 European Association for the Study of the Liver (EASL) guidelines recommended sofosbuvir-ledipasvir, sofosbuvir-velpatasvir or sofosbuvir plus daclatasvir for 8 weeks in acute HCV infection, with a longer duration of 12 weeks recommended for those infected with HIV and/or baseline HCV RNA levels >1,000,000 IU/ml...
May 17, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29771360/patient-and-treatment-characteristics-by-infecting-organism-in-cerebrospinal-fluid-shunt-infection
#5
Tamara D Simon, Matthew P Kronman, Kathryn B Whitlock, Samuel R Browd, Richard Holubkov, John R W Kestle, Abhaya V Kulkarni, Marcie Langley, David D Limbrick, Thomas G Luerssen, Jerry Oakes, Jay Riva-Cambrin, Curtis Rozzelle, Chevis N Shannon, Mandeep Tamber, John C Wellons Iii, William E Whitehead, Nicole Mayer-Hamblett
Background: Previous studies of cerebrospinal fluid (CSF) shunt infection treatment have been limited in size and unable to compare patient and treatment characteristics by infecting organism. Our objective was to describe variation in patient and treatment characteristics for children with first CSF shunt infection, stratified by infecting organism subgroups outlined in the 2017 Infectious Disease Society of America's (IDSA) guidelines. Methods: We studied a prospective cohort of children <18 years of age undergoing treatment for first CSF shunt infection at one of 7 Hydrocephalus Clinical Research Network hospitals from April 2008 to December 2012...
May 15, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29747285/-expert-consensus-on-the-diagnosis-and-treatment-of-cryptococcal-meningitis
#6
Z Y Liu, G Q Wang, L P Zhu, X J Lyu, Q Q Zhang, Y S Yu, Z H Zhou, Y B Liu, W P Cai, R Y Li, W H Zhang, F J Zhang, H Wu, Y C Xu, H Z Lu, T S Li
Cryptococcal meningitis is a common and refractory central nervous system infection, with high rates of mortality and disability. The experts of the Society of Infectious Diseases of Chinese Medical Association have reached this consensus after a thorough discussion. Based on the current situation of cryptococcal meningitis in China, the management of cryptococcal meningitis includes 6 aspects: introduction, microorganism identification, clinical manifestations and diagnosis, principles of antifungal therapy, treatment of refractory and recurrent meningitis, treatment of intracranial hypertension...
May 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29744261/antimicrobial-stewardship-without-infectious-disease-physician-for-patients-with-candidemia-a-before-and-after-study
#7
Minoru Murakami, Hirokazu Komatsu, Masahide Sugiyama, Yuhei Ichikawa, Kyoko Ide, Rumi Tsuchiya, Kenji Kunieda, Akiko Magishi, Gaku Akiyama, Fumihide Miura, Kunihiko Okada, Masaya Ikezoe
Background: Little is known about the effects of antimicrobial stewardship team (AST) without infectious disease physician (IDP) on clinical outcome in patients with candidemia. Methods: We conducted a before and after study involving patients with hospital-acquired candidemia at a tertiary hospital without IDPs. The AST consisted of physicians, pharmacists, nurse, microbiologist, and administrative staff. A candidemia care bundle was developed based on the Infectious Disease Society of America (IDSA) guideline...
May 2018: Journal of General and Family Medicine
https://www.readbyqxmd.com/read/29738561/high-dose-versus-standard-dose-amoxicillin-clavulanate-for-clinically-diagnosed-acute-bacterial-sinusitis-a-randomized-clinical-trial
#8
Andrea Matho, Mary Mulqueen, Miyuki Tanino, Aaron Quidort, Jesse Cheung, Jennifer Pollard, Julieta Rodriguez, Supraja Swamy, Brittany Tayler, Gina Garrison, Ashar Ata, Paul Sorum
BACKGROUND: The recommended treatment for acute bacterial sinusitis in adults, amoxicillin with clavulanate, provides only modest benefit. OBJECTIVE: To see if a higher dose of amoxicillin will lead to more rapid improvement. DESIGN, SETTING, AND PARTICIPANTS: Double-blind randomized trial in which, from November 2014 through February 2017, we enrolled 315 adult outpatients diagnosed with acute sinusitis in accordance with Infectious Disease Society of America guidelines...
2018: PloS One
https://www.readbyqxmd.com/read/29715222/alpha-defensin-lateral-flow-test-for-diagnosis-of-periprosthetic-joint-infection-not-a-screening-but-a-confirmatory-test
#9
Nora Renz, Katsiaryna Yermak, Carsten Perka, Andrej Trampuz
BACKGROUND: Determination of alpha defensin in synovial fluid has shown promising results for diagnosing periprosthetic joint infection (PJI). The purposes of our study were to assess the performance of alpha defensin lateral flow (ADLF) test for the diagnosis of acute and chronic PJI using 3 classification systems and to compare its performance with the synovial fluid leukocyte count. METHODS: Patients in whom aspiration of a prosthetic hip or knee joint was performed before revision arthroplasty were prospectively included...
May 2, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29698961/impact-of-serum-vancomycin-trough-levels-in-the-treatment-of-central-nervous-system-shunt-infections-caused-by-coagulase-negative-staphylococci
#10
Ashley Gibson, Sheldon L Kaplan, Jesus G Vallejo
Coagulase-negative staphylococci (CoNS) are a common cause of pediatric ventricular shunt infections. The Infectious Diseases Society of America recommends vancomycin serum troughs of 15-20 µg/mL when treating CoNS shunt infections in adult patients. We report a series of pediatric cases of CoNS shunt infections in which clinical cure was obtained with troughs < 15 µg/mL. These findings question the relevance of this recommendation in pediatric patients.
April 26, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29670404/evaluation-of-vancomycin-therapy-in-the-adult-icus-of-a-teaching-hospital-in-southern-iran
#11
Afsaneh Vazin, Motahare Mahi Birjand, Masoud Darake
Background: Vancomycin resistance in intensive care units (ICUs) accounts for significant morbidity and excess costs. The objective of the present study was to determine the appropriateness of vancomycin use in the various ICUs of Nemazee Hospital, Shiraz, Iran. Methods: This prospective study was performed on 95 critically ill patients (48 males and 47 females) who were treated with vancomycin for at least 3 subsequent doses in 6 ICUs during 12 months. Required demographic, clinical, and paraclinical data were collected by a pharmacist...
2018: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/29663961/systematic-review-and-meta-analysis-of-adjunctive-corticosteroids-in-the-treatment-of-tuberculous-pericarditis
#12
I A George, B Thomas, J S Sadhu
SETTING: Tuberculosis (TB) is the most common cause of pericarditis worldwide and carries a high mortality, even with effective anti-tuberculosis treatment. In the light of a randomized control trial in 2014, the American Thoracic Society and the Centers for Disease Control and Prevention/Infectious Diseases Society of America recently revised their recommendations against the routine use of adjunctive corticosteroids. OBJECTIVE: To evaluate the strength of evidence that resulted in this reversal of the guideline recommendations on the use of adjunctive corticosteroids in TB pericarditis by a meta-analysis, followed by a sensitivity analysis...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29663539/cryptococcal-infections-over-a-15-year-period-at-a-tertiary-facility-impact-of-guideline-management
#13
Ian Gassiep, Joel Douglas, Theophilus I Emeto, Katherine Crawley, Elliott G Playford
BACKGROUND: Cryptococcosis is an invasive fungal infection caused primarily by Cryptococcus neoformans and Cryptococcus gattii species, presenting predominantly as meningoencephalitis. The aim of this study is to assess all cryptococcal infections managed at our facility from 2001-2015 to determine incidence, risk factors, and comparison of outcomes prior to and following introduction of the 2010 Infectious Disease Society of America (IDSA) guidelines. METHODS: Retrospective analysis of all patients diagnosed and treated for cryptococcal infection occurring between January 2001 and December 2015...
April 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29644966/diagnosis-and-treatment-of-neurocysticercosis-2017-clinical-practice-guidelines-by-the-infectious-diseases-society-of-america-idsa-and-the-american-society-of-tropical-medicine-and-hygiene-astmh
#14
A Clinton White, Christina M Coyle, Vedantam Rajshekhar, Gagandeep Singh, W Allen Hauser, Aaron Mohanty, Hector H Garcia, Theodore E Nash
No abstract text is available yet for this article.
April 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29617787/diagnosis-and-treatment-of-neurocysticercosis-2017-clinical-practice-guidelines-by-the-infectious-diseases-society-of-america-idsa-and-the-american-society-of-tropical-medicine-and-hygiene-astmh
#15
A Clinton White, Christina M Coyle, Vedantam Rajshekhar, Gagandeep Singh, W Allen Hauser, Aaron Mohanty, Hector H Garcia, Theodore E Nash
No abstract text is available yet for this article.
April 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29609223/utility-of-community-acquired-pneumonia-severity-scores-in-guiding-disposition-from-the-emergency-department-intensive-care-or-short-stay-unit
#16
Julian M Williams, Jaimi H Greenslade, Kevin H Chu, Anthony Ft Brown, Jeffrey Lipman
OBJECTIVE: To assess community-acquired pneumonia severity scores from two perspectives: (i) prediction of ICU admission or mortality; and (ii) utility of low scores for prediction of discharge within 48 h, potentially indicating suitability for short-stay unit admission. METHODS: Patients with community-acquired pneumonia were identified from a prospective database of emergency patients admitted with infection. Pneumonia severity index (PSI), CURB-65, CORB, CURXO, SMARTCOP scores and the Infectious Diseases Society of America/American Thoracic Society (IDSA/ATS) minor criteria were calculated...
April 2, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29566611/treatment-of-hcv-in-the-department-of-corrections-in-the-era-of-oral-medications
#17
Richard K Sterling, Reena Cherian, Shawn Lewis, Kathleen Genther, Carolyn Driscoll, Kelly Martin, Mary Beth Goode, Scott Matherly, Mohammad S Siddiqui, Velimir A Luketic, R Todd Stravitz, Puneet Puri, Hannah Lee, Paula Smith, Vaishali Patel, Arun J Sanyal
Chronic hepatitis C virus (HCV) is widely prevalent in the Virginia Department of Corrections (DOC). However, sustained virologic response (SVR) with all oral direct-acting antiviral (DAA) therapy is unknown. HCV treatment was provided through telemedicine following guidelines of the American Association for the Study of Liver Diseases and Infectious Diseases Society of America. SVR12 in the DOC was compared in two control groups: privately insured and indigent patients receiving care in HCV treatment clinics by the same providers during the same time period...
January 1, 2018: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/29562266/clinical-practice-guidelines-for-clostridium-difficile-infection-in-adults-and-children-2017-update-by-the-infectious-diseases-society-of-america-idsa-and-society-for-healthcare-epidemiology-of-america-shea
#18
L Clifford McDonald, Dale N Gerding, Stuart Johnson, Johan S Bakken, Karen C Carroll, Susan E Coffin, Erik R Dubberke, Kevin W Garey, Carolyn V Gould, Ciaran Kelly, Vivian Loo, Julia Shaklee Sammons, Thomas J Sandora, Mark H Wilcox
A panel of experts was convened by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) to update the 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations for children (following the adult recommendations for epidemiology, diagnosis, and treatment), includes significant changes in the management of this infection and reflects the evolving controversy over best methods for diagnosis...
March 19, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29559518/paradigm-for-diagnosing-mycobacterial-disease-direct-detection-and-differentiation-of-mycobacterium-tuberculosis-complex-and-non-tuberculous-mycobacteria-in-clinical-specimens-using-multiplex-real-time-pcr
#19
Jeong-Uk Kim, Dae-Shick Ryu, Choong-Hwan Cha, Seon-Hee Park
AIMS: Mycobacterium tuberculosis and non-tuberculous mycobacteria (NTM) are clinically different, and the rapid detection and differentiation of M. tuberculosis complex (MTBC) and NTM is crucial for patient management and infection control. Given the slow growth of most pathogenic mycobacteria, nucleic acid amplification assays are excellent tools for direct identification of mycobacteria in clinical specimens. Recently, a multiplex real-time PCR assay was developed that can directly detect 20 mycobacterial species in clinical specimens...
March 20, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29528891/complicated-pneumonia-current-concepts-and-state-of-the-art
#20
Michael C Tracy, Roshni Mathew
PURPOSE OF REVIEW: This review aims to provide clinicians engaged in the care of infants and children an update on the current understanding of the epidemiology, etiology, diagnostic evaluation, and clinical management of complicated pneumonia. The review provides timely information surrounding areas of consensus and ongoing research. RECENT FINDINGS: The epidemiology and etiologies of complicated pneumonia continue to evolve over the past several decades in context of the introduction of new vaccines...
June 2018: Current Opinion in Pediatrics
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