Frederick A Zeiler, Ari Ercole, Manuel Cabeleira, Erta Beqiri, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, David K Menon, Christos Lazaridis, Peter Smielewski, Marek Czosnyka
BACKGROUND: Patient-specific epidemiologic intracranial pressure (ICP) thresholds in adult traumatic brain injury (TBI) have emerged, using the relationship between pressure reactivity index (PRx) and ICP, displaying stronger association with outcome over existing guideline thresholds. The goal of this study was to explore this relationship in a multi-center cohort in order to confirm the previous finding. METHODS: Using the Collaborative European Neuro Trauma Effectiveness Research in TBI (CENTER-TBI) high-resolution intensive care unit cohort, we derived individualized epidemiologic ICP thresholds for each patient using the relationship between PRx and ICP...
January 2021: Journal of Neurosurgical Anesthesiology