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https://www.readbyqxmd.com/read/28716656/atomoxetine-in-abstinent-cocaine-users-cognitive-subjective-and-cardiovascular-effects
#1
Elise E DeVito, Aryeh I Herman, Noah S Konkus, Huiping Zhang, Mehmet Sofuoglu
No pharmacotherapies are approved for the treatment of cocaine use disorders (CUD). Behavioral treatments for CUD are efficacious for some individuals, but recovery rates from CUD remain low. Cognitive impairments in CUD have been linked with poorer clinical outcomes. Cognitive enhancing pharmacotherapies have been proposed as promising treatments for CUD. Atomoxetine, a norepinephrine transporter inhibitor, shows potential as a treatment for CUD based on its efficacy as a cognitive enhancer in other clinical populations and impact on addictive processes in preclinical and human laboratory studies...
July 14, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28705298/methamphetamine-related-disorders
#2
Euphrosyne Gouzoulis-Mayfrank, Roland Härtel-Petri, Willem Hamdorf, Ursula Havemann-Reinecke, Stephan Mühlig, Norbert Wodarz
BACKGROUND: Methamphetamine is considered more dangerous than other stimulants because of its acute complications, long-term neurotoxicity, and potential for drug dependence. Until now, there have been no evidence-based guidelines for the treatment of methamphetamine-related disorders, either in Germany or abroad. METHODS: A systematic literature search was performed on the treatment of methamphetamine-related disorders. Based on this literature review, a multidisciplinary expert panel developed recommendations using the nominal group technique...
June 30, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28704148/-i-was-not-sick-and-i-didn-t-need-to-recover-methadone-maintenance-treatment-mmt-as-a-refuge-from-criminalization
#3
David Frank
BACKGROUND: Methadone Maintenance Treatment (MMT) in the United States (U.S.) has been undergoing a shift towards conceptualizing the program as recovery-based treatment. Although recovery is seen by some as a means to restore MMT to its rightful position as a medically-based treatment for addiction, it may not represent the experiences, or meet the needs of people who use drugs (PWUD), many of whom who use the program as a pragmatic means of reducing harms associated with criminalization...
July 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28704116/popular-views-on-addictions-and-on-prospects-for-recovery-in-poland
#4
Justyna I Klingemann, Harald Klingemann, Jacek Moskalewicz
BACKGROUND: Popular views of addictive substances and behaviors constitute an important research topic because these views have an impact upon the functioning of treatment systems and societal responses to substance use disorders. METHODS: The analysis is based on a random sample of N = 1000 telephone interviews collected in Poland in 2013. Questionnaire measures targeted such issues as the perceived risks of addictions and beliefs about potential recovery from various types of addictions...
July 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28699698/reduced-dosing-and-liability-in-methadone-maintenance-treatment-by-targeting-oestrogen-signal-for-morphine-addiction
#5
Yao-Chang Chiang, Ruey-Yun Wang, Chieh-Liang Huang, Shue-Hwa Chen, Wen-Jing Ho, Hsien-Yuan Lane, Ing-Kang Ho, Hwei-Ting Yang, Wen-Lung Ma
Methadone maintenance treatment (MMT) is the major tapering therapy for morphine addictive patients. There have gender differences reported in response to MMT. This study discovered that the estrogen-response element single nucleotide polymorphism (ERE-SNP; rs16974799, C/T) of cytochrome 2B6 gene (cyp2b6; methadone catabolic enzyme) responded differently to MMT dosing. Oestradiol was associated with high MMT dosing, high enantiomer (R- or S-) of 2-ethylidene-1,5-dimethyl-3,3-dipheny-pyrrolidine (EDDP; methadone metabolite) to methadone ratio and increased drug-seeking behaviour, implicating oestradiol-CYP-EDDP/methadone axis decreasing MMT efficacy...
July 12, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28697909/women-and-the-opioid-crisis-historical-context-and-public-health-solutions
#6
REVIEW
Mishka Terplan
Driven by a legitimate but overly opioid-focused response to pain, the United States is currently experiencing an opioid crisis, a crisis with parallels to the first opioid epidemic at the turn of the 20th century. Women, particularly white reproductive-age women, are increasingly the face of the opioid crisis. Given the penetration of opioid misuse and addiction across all income and insurance strata, any provider who cares for women needs to be prepared to assess and evaluate opioid use, misuse, and addiction...
July 8, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28696413/genome-wide-meta-analysis-of-copy-number-variations-with-alcohol-dependence
#7
A Sulovari, Z Liu, Z Zhu, D Li
Genetic association studies and meta-analyses of alcohol dependence (AD) have reported AD-associated single nucleotide polymorphisms (SNPs). These SNPs collectively account for a small portion of estimated heritability in AD. Recent genome-wide copy number variation (CNV) studies have identified CNVs associated with AD and substance dependence, suggesting that a portion of the missing heritability is explained by CNV. We applied PennCNV and QuantiSNP CNV calling algorithms to identify consensus CNVs in five AD cohorts of European and African origins...
July 11, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28693573/a-qualitative-assessment-of-an-abstinence-oriented-therapeutic-community-for-prisoners-with-substance-use-disorders-in-kyrgyzstan
#8
Lyuba Azbel, Julia Rozanova, Ingo Michels, Frederick L Altice, Heino Stöver
BACKGROUND: Kyrgyzstan, where HIV is concentrated in prisons and driven by injection drug use, provides a prison-based methadone maintenance therapy program as well as abstinence-oriented therapeutic community based on the 12-step model called the "Clean Zone." We aimed to qualitatively assess how prisoners navigate between these treatment options to understand the persistence of the Clean Zone despite a lack of evidence to support its effectiveness in treating opioid use disorders. METHODS: We conducted an analysis of policy documents and over 60 h of participant observation in February 2016, which included focus groups with a convenience sample of 20 therapeutic community staff members, 110 prisoners across three male and one female prisons, and qualitative interviews with two former Clean Zone participants...
July 10, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28692420/use-of-a-smartphone-recovery-tool-for-latinos-with-co-occurring-alcohol-and-other-drug-disorders-and-mental-disorders
#9
Jordana Muroff, Winslow Robinson, Deborah Chassler, Luz M López, Erika Gaitan, Lena Lundgren, Claudia Guauque, Susan Dargon-Hart, Emily Stewart, Diliana Dejesus, Kimberly Johnson, Klaren Pe-Romashko, David H Gustafson
OBJECTIVE: Addressing alcohol and other drug disorders (AOD) and other mental disorders (MD) among adult Hispanics/Latinos is of critical concern being one of the fastest growing ethnic groups with a disproportionate rate of disease, mental disorders, and poverty. Although improvement in outcomes is associated with sustained participation in ongoing treatment for co-occurring AOD/MD, continuing care is rare for these chronic conditions, especially for Latinos with more limited access to culturally and linguistically competent services...
July 10, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28690668/white-opioids-pharmaceutical-race-and-the-war-on-drugs-that-wasn-t
#10
Julie Netherland, Helena Hansen
The US 'War on Drugs' has had a profound role in reinforcing racial hierarchies. Although Black Americans are no more likely than Whites to use illicit drugs, they are 6-10 times more likely to be incarcerated for drug offenses. Meanwhile, a very different system for responding to the drug use of Whites has emerged. This article uses the recent history of White opioids - the synthetic opiates such as OxyContin(®) that gained notoriety starting in the 1990s in connection with epidemic prescription medication abuse among White, suburban and rural Americans and Suboxone(®) that came on the market as an addiction treatment in the 2000s - to show how American drug policy is racialized, using the lesser known lens of decriminalized White drugs...
June 2017: BioSocieties
https://www.readbyqxmd.com/read/28690183/perinatal-protein-deprivation-facilitates-morphine-cross-sensitization-to-cocaine-and-enhances-%C3%AE-fosb-expression-in-adult-rats
#11
María Cecilia Perondi, María Cecilia Gutiérrez, Analía Valdomero, Gabriel Ricardo Cuadra
Previous studies have indicated that neural changes induced by early nutritional insult cause an altered response to pharmacological treatments, including addictive drugs. This study evaluates the influence of perinatal protein malnutrition in developing cross-sensitization to cocaine-induced rewarding effects in animals pre-exposed to morphine. Different groups of well-nourished (C-rats) and protein-deprived animals (D-rats) were treated twice a day for three days with increasing doses of morphine or with saline...
July 6, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28688295/contingency-management-interventions-for-non-prescribed-drug-use-during-treatment-for-opiate-addiction-a-systematic-review-and-meta-analysis
#12
REVIEW
Tom S Ainscough, Ann McNeill, John Strang, Robert Calder, Leonie S Brose
BACKGROUND AND AIMS: Use of non-prescribed drugs during treatment for opiate addiction reduces treatment success, creating a need for effective interventions. This review aimed to assess the efficacy of contingency management, a behavioural treatment that uses rewards to encourage desired behaviours, for treating non-prescribed drug use during opiate addiction treatment. METHODS: A systematic search of the databases Embase, PsychInfo, PsychArticles and Medline from inception to March 2015 was performed...
June 24, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28683227/supervised-injectable-heroin-a-clinical-perspective
#13
James Bell, Rob van der Waal, John Strang
BACKGROUND: Six recent randomised control trials (RCTs) have suggested that supervised injectable heroin (SIH) can be effective in patients who persist in street heroin use during methadone treatment. However, short-term randomised control trials have limitations in assessing the effectiveness of treatments for addictive disorders, which are chronic and relapsing disorders of motivation. These RCTs particularly fail to capture the process of the SIH treatment and the diversity of influence and change over time...
July 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28681200/microrna-expression-signature-of-methamphetamine-use-and-addiction-in-the-rat-nucleus-accumbens
#14
Maw Shin Sim, Tomoko Soga, Vijayapandi Pandy, Yuan Seng Wu, Ishwar S Parhar, Zahurin Mohamed
Methamphetamine (METH) is a highly addictive psycho-stimulant that induces behavioral changes due to high level of METH-induced dopamine in the brain. Nucleus accumbens (NAc) plays an important role in these changes, especially in drug addiction. However, little is known about the underlying molecular mechanisms of METH-induced addiction. The objective of this study was to establish a behavioral model of METH use and addiction using escalating doses of METH over 15 days and to determine the global miRNA expression profiling in NAc of METH-addicted rats...
July 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28678934/-clinical-and-social-vulnerabilities-in-crack-users-according-to-housing-status-a-multicenter-study-in-six-brazilian-state-capitals
#15
Silvia Chwartzmann Halpern, Juliana Nichterwitz Scherer, Vinicius Roglio, Sibele Faller, Anne Sordi, Felipe Ornell, Carla Dalbosco, Flavio Pechansky, Félix Kessler, Lísia von Diemen
The study had the goal to evaluate psychoactive substance use severity, violence, physical and emotional health of crack users who seeks specialized treatment in Psychosocial Care Centers for Alcohol and Drugs (CAPSad) concerning housing status. This is a multicenter cross-sectional study in six Brazilian capitals with 564 crack users categorized into two groups (1) users who have been homeless sometime in life (n = 266) and (2) individuals who have never lived on streets (n = 298). To assess the substance use severity and the characteristics of the individuals, the Addiction Severity Index, 6th version (ASI-6) was used...
July 3, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28677919/prevalence-and-predictors-of-substance-use-disorders-among-homeless-women-seeking-primary-care-an-11-site-survey
#16
Carole Christofk Upshur, Darlene Jenkins, Linda Weinreb, Lillian Gelberg, Elizabeth Aaker Orvek
BACKGROUND AND OBJECTIVES: Homeless women have shown high rates of substance use disorders (SUD), but many studies are more than a decade old, limited in geographic location, or focus only on women living outdoors or in shelters. The purpose of this study was to obtain a more current and representative sample of homeless women and the prevalence and predictors of substance use disorders among women seeking primary care at Health Care for the Homeless clinics across the US. METHODS: Eleven Health Care for the Homeless (HCH) clinics in nine states contributed proportionally to a sample of n = 780 female patients who completed a self-administered survey including demographics, housing history, health, mental health, and drug and alcohol use...
July 5, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28677095/the-effects-of-hallucinogens-on-gene-expression
#17
David A Martin, Charles D Nichols
The classic serotonergic hallucinogens, or psychedelics, have the ability to profoundly alter perception and behavior. These can include visual distortions, hallucinations, detachment from reality, and mystical experiences. Some psychedelics, like LSD, are able to produce these effects with remarkably low doses of drug. Others, like psilocybin, have recently been demonstrated to have significant clinical efficacy in the treatment of depression, anxiety, and addiction that persist for at least several months after only a single therapeutic session...
July 5, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28675785/gas6-expressing-and-self-sustaining-cancer-cells-in-3d-spheroids-activate-the-pdk-rsk-mtor-pathway-for-survival-and-drug-resistance
#18
Christine Baumann, Axel Ullrich, Robert Torka
AXL Receptor Tyrosine Kinase (RTK) inhibition presents a promising therapeutic strategy for aggressive tumor subtypes, as AXL signaling is upregulated in many cancers resistant to first line treatments. Furthermore, the AXL ligand Growth Arrest-Specific gene 6 (GAS6) has recently been linked to cancer drug resistance. Here, we established that challenging conditions, such as serum deprivation, divide AXL overexpressing tumor cell lines into non-self-sustaining and self-sustaining subtypes in 3D spheroid culture...
July 4, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28673442/when-habits-are-dangerous-alcohol-expectancies-and-habitual-decision-making-predict-relapse-in-alcohol-dependence
#19
Miriam Sebold, Stephan Nebe, Maria Garbusow, Matthias Guggenmos, Daniel J Schad, Anne Beck, Soeren Kuitunen-Paul, Christian Sommer, Robin Frank, Peter Neu, Ulrich S Zimmermann, Michael A Rapp, Michael N Smolka, Quentin J M Huys, Florian Schlagenhauf, Andreas Heinz
BACKGROUND: Addiction is supposedly characterized by a shift from goal-directed to habitual decision making, thus facilitating automatic drug intake. The two-step task allows distinguishing between these mechanisms by computationally modeling goal-directed and habitual behavior as model-based and model-free control. In addicted patients, decision making may also strongly depend upon drug-associated expectations. Therefore, we investigated model-based versus model-free decision making and its neural correlates as well as alcohol expectancies in alcohol-dependent patients and healthy controls and assessed treatment outcome in patients...
May 22, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28668695/-what-constitutes-a-problem-producing-alcohol-problems-through-online-counselling-encounters
#20
Michael Savic, Nyssa Ferguson, Victoria Manning, Ramez Bathish, Dan I Lubman
Typically, health policy, practice and research views alcohol and other drug (AOD) 'problems' as objective things waiting to be detected, diagnosed and treated. However, this approach to policy development and treatment downplays the role of clinical practices, tools, discourses, and systems in shaping how AOD use is constituted as a 'problem'. For instance, people might present to AOD treatment with multiple psycho-social concerns, but usually only a singular AOD-associated 'problem' is considered serviceable...
June 29, 2017: International Journal on Drug Policy
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