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Cardiac troponin I

Mehrnoosh Sedighi, Afshin Nazari, Mahdieh Faghihi, Mahmoud Rafieian-Kopaei, Arash Karimi, Maryam Moghimian, Seyyed Ali Mozaffarpur, Marzieh Rashidipour, Mehrdad Namdari, Mostafa Cheraghi, Bahram Rasoulian
Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion...
June 19, 2018: Phytotherapy Research: PTR
K Wang, R Meng, H Zhang, B-C Xu
OBJECTIVE: To investigate the expression of kir6.2 subunit of the sarcKATP channel in exercise-induced myocardial injury and to elucidate the underlying mechanism of myocardial protection by sarcKATP channels. MATERIALS AND METHODS: Healthy male Sprague Dawley(SD) rats were divided into the Control (C) and the Exhaustive Exercise (EE) group. The one-time exhaustive exercise-induced myocardial injury model was established on a treadmill at a speed of 35 m/min. Alterations in myocardial ischemia and hypoxia were examined by hematoxylin-basic fuchsin-picric acid (HBFP) staining and the concentration of cardiac Troponin I (cTnl), a sensitive and specific marker for myocardial injury, was detected using immunochemiluminescence analysis...
June 2018: European Review for Medical and Pharmacological Sciences
Guangdong Lu, Zhenyu Jia, Qingquan Zu, Jinxing Zhang, Linbo Zhao, Haibin Shi
Acute pulmonary embolism (APE)-induced inflammation contributes to cardiomyocyte injury and dysfunction in the right ventricle (RV) of the heart. The interactions of cyclophilin A with its ligand extracellular matrix metalloproteinase inducer (EMMPRIN or CD147) may be involved in this inflammatory process. To this end, here we induced APE by intravenous injections of microspheres in Sprague-Dawley rats. We found that after the APE, cyclophilin A, and CD147 levels increased synchronously in RV tissue following APE and peaked at 24 hours...
June 18, 2018: Journal of Biological Chemistry
Zhixiong Zhong, Jing Liu, Qifeng Zhang, Wei Zhong, Bin Li, Cunren Li, Zhidong Liu, Min Yang, Pingsen Zhao
BACKGROUND Periprocedural myocardial injury (PMI) is known to be a predictor of postprocedural cardiovascular morbidity and mortality following a percutaneous coronary intervention (PCI). However, the correlation between low-density lipoprotein cholesterol and periprocedural myocardial injury in patients following elective PCI in southern China remains unclear. Therefore, we aimed to investigate the association of preoperative low-density lipoprotein cholesterol (LDL-C) levels with PMI in patients following elective PCI...
June 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
J L Pérez-Navero, C Merino-Cejas, I Ibarra de la Rosa, S Jaraba-Caballero, M Frias-Perez, E Gómez-Guzmán, M Gil-Campos, M J de la Torre-Aguilar
OBJECTIVE: To determine the predictive value of the inotropic score (IS) and vasoactive-inotropic score (VIS) in low cardiac output syndrome (LCOS) in children after congenital heart disease surgery involving cardiopulmonary bypass (CPB), and to establish whether mid-regional pro-adrenomedullin (MR-proADM) and cardiac troponin I (cTn-I), associated to the IS and VIS scores, increases the predictive capacity in LCOS. DESIGN: A prospective observational study was carried out...
June 14, 2018: Medicina Intensiva
Lorena Bavia, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Miguel Ibraim Abboud Hanna Sobrinho, Renato Mitsunori Nisihara, Iara Jose de Messias-Reason
BACKGROUND: Acute myocardial infarction (AMI) is a potentially fatal condition, being a major cause of death worldwide. Ischemia suffered during AMI causes tissue damage, leading to an inflammatory process. Moreover, myocardial injury can generate damage-associated molecular patterns that activate pattern recognition molecules including some complement proteins. METHODS: Here we investigated products of complement activation, C3d and soluble C5b9 (sC5b9), as potential biomarkers for myocardial injury and inflammation, as well as serum cytokines (IL-6 and TNF-alpha), alpha-1-acid glycoprotein (AGP), and classical markers of myocardial necrosis (creatine kinase, creatine kinase-MB isoform, myoglobin and troponin-I) in a longitudinal study of patients with AMI (from admission, 6 h and 12 h post admission, and at discharge from hospital)...
June 14, 2018: Immunology Letters
Robert H Christenson, Kristin Mullins, Show-Hong Duh
No abstract text is available yet for this article.
June 14, 2018: Clinical Biochemistry
Kaytee L Pokrzywinski, Thomas G Biel, Elliot T Rosen, Julia L Bonanno, Baikuntha Aryal, Francesca Mascia, Delaram Moshkelani, Steven Mog, V Ashutosh Rao
BACKGROUND: Doxorubicin (DOX), an anthracycline therapeutic, is widely used to treat a variety of cancer types and known to induce cardiomyopathy in a time and dose-dependent manner. Postmenopausal and hypertensive females are two high-risk groups for developing adverse effects following DOX treatment. This may suggest that endogenous reproductive hormones can in part suppress DOX-induced cardiotoxicity. Here, we investigated if the endogenous fluctuations in 17β-estradiol (E2) and progesterone (P4) can in part suppress DOX-induced cardiomyopathy in SST-2 tumor-bearing spontaneously hypersensitive rats (SHRs) and evaluate if exogenous administration of E2 and P4 can suppress DOX-induced cardiotoxicity in tumor-bearing ovariectomized SHRs (ovaSHRs)...
June 15, 2018: Biology of Sex Differences
Xu Han, Hossein Shokri Kojori, Roger M Leblanc, Sung Jin Kim
Cancers and many other diseases, such as hepatocellular carcinoma (HCC) and cardiovascular diseases (CVD), have threatened human lives for centuries. Therefore, a novel technique for such disease prediction, therefore, is in an urgent demand for timely treatment. Biomarkers - alpha-L-fucosidase (AFU) for HCC and cardiac troponin I (cTnI) for CVD - have proven to be essential in the role of disease detection. Herein, we report on an ultrasensitive plasmonic biosensor that converts plasmonic absorption to electrical current in order to detect AFU and cTnI using whole human blood in a real-time and parallel fashion...
June 15, 2018: Analytical Chemistry
Rajveer Joea, Sarah J Strube, Todd K Zynda
Spontaneous coronary artery dissection (SCAD) is a variant of acute coronary syndrome (ACS) that is poorly understood. SCAD has been linked to fibromuscular dysplasia (FMD), connective tissue disease (CTD), pregnancy and hormonal imbalance, systemic inflammatory conditions (e.g. IBD, vasculitis), and coronary artery vasospasm rather than traditional cardiac risk factors. Symptomology generally accompanying SCAD is indistinguishable from ACS making the timely recognition and diagnosis vital for prompt treatment...
June 2018: Cardiology Research
Yang Lv, Bo Liu, Yuan Liu, Haoyu Wang, Haiping Wang
Transforming growth factor β1 (TGF-β1) and salvianolic acid B (Sal-B) are key signaling factors for stem cell differentiation into cardiomyocytes (CMs). The present study compared the biological effect of TGF-β1 and Sal-B, alone or in combination, on bone marrow mesenchymal stromal cells (BMSCs) that differentiate into myocardial-like cells in a simulated myocardial microenvironment in vitro . BMSCs were isolated from bones of limbs of 10 male Sprague Dawley rats and cultured. The 2nd-generation BMSCs were co-incubated with TGF-β1 and Sal-B, alone or in combination, for 72 h...
June 2018: Experimental and Therapeutic Medicine
Leona Wall, Annika Mohr, Florenza Lüder Ripoli, Nayeli Schulze, Camila Duarte Penter, StephanOscar Hungerbuehler, Jan-Peter Bach, Karin Lucas, Ingo Nolte
Exercise intolerance is the first symptom of heart disease. Yet an objective and standardised method in canine cardiology to assess exercise capacity in a clinical setting is lacking. In contrast, exercise testing is a powerful diagnostic tool in humans, providing valuable information on prognosis and impact of therapeutic intervention. To investigate whether an exercise test reveals differences between dogs with early stage mitral regurgitation (MR) and dogs without cardiac disease, 12 healthy beagles (healthy group, HG) and 12 dogs with presymptomatic MR (CHIEF B1 / B2, patient group, PG) underwent a six-stage submaximal exercise test (ET) on a motorised treadmill...
2018: PloS One
Lan Ding, Chuanming Bai, Ying Liu
Preeclampsia is one of the most frequent and difficult illnesses in pregnancy, which jeopardizes both mother and fetus. There are several diagnostic criteria for preeclampsia. However, the preeclampsia-associated myocardial damage has not been described. In this study, we employed reduced uterine perfusion pressure (RUPP) to generate a rat model of preeclampsia for the evaluation of myocardial damage in late-gestation rats. The expressions of cardiac injury markers were analyzed by immunohistochemistry and ELISA...
June 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Zeming Zhang, Kun Pan, Lu Chen, Yancun Wang
The aim of the present study was to investigate the effect of nitric oxide inhalation (NOI) on cardiac troponin I (CTnI) levels and mean pulmonary arterial pressure (mPAP) in rabbits with acute massive pulmonary embolism (AMPE). Thirty rabbits were used as animal models for AMPE and received different treatments. A total of 4 h after successful modeling, the control group (CON, n=10) received conventional thrombolysis, whereas the treatment group (TRE, n=10) received conventional thrombolysis plus NOI. The experimental group (EXP, n=10) did not receive any treatments...
July 2018: Experimental and Therapeutic Medicine
Ai-Jie Liu, Chun-Xia Pang, Guo-Qiang Liu, Shi-Duan Wang, Chun-Qin Chu, Lin-Zhang Li, Yan Dong, De-Zhang Zhu
We aimed to investigate whether the cardioprotection of sevoflurane against ischemia/reperfusion (IR) injury is via inhibiting endoplasmic reticulum stress (ERS). The rat in vivo model of myocardial IR injury was induced by ligation of the left anterior descending (LAD) coronary artery. Sevoflurane significantly ameliorated the reduced cardiac function, increased infarct size and elevated troponin I level and lactate dehydrogenase (LDH) activity in plasma induced by IR injury. Sevoflurane suppressed the I/R-induced myocardial apoptosis...
June 12, 2018: Canadian Journal of Physiology and Pharmacology
Zeynep Yildiz, Abdulkadir Koçer, Şahin Avşar, Göksel Cinier
BACKGROUND AND PURPOSE: Cardiac troponin I (cTnI) is a reliable marker to diagnose acute myocardial infarction, but the pathophysiological explanation for the increase in cTnI levels in patients with acute ischemic stroke (IS) remains unknown. To overcome this question, we aimed to compare serum cTnI levels in acute coronary syndrome (ACS) concomitant with and without stroke. By doing like this, we thought that we could demonstrate the effect of stroke on TrpI level. METHODS: Serum cTnI levels of 41 patients having ACS with acute IS during hospitalization were compared with 97 control patients having only ACS...
June 1, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
K Wildi, H Singeisen, R Twerenbold, P Badertscher, D Wussler, L J J Klinkenberg, S J R Meex, T Nestelberger, J Boeddinghaus, Ò Miró, F J Martin-Sanchez, B Morawiec, P Muzyk, J Parenica, D I Keller, N Geigy, E Potlukova, Z Sabti, N Kozhuharov, C Puelacher, J du Fay de Lavallaz, M Rubini Gimenez, S Shrestha, G Marzano, K Rentsch, S Osswald, T Reichlin, C Mueller
BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) blood concentrations were shown to exhibit a diurnal rhythm, characterized by gradually decreasing concentrations throughout daytime, rising concentrations during nighttime and peak concentrations in the morning. We aimed to investigate whether this also applies to (h)s-cTnI assays and whether it would affect diagnostic accuracy for acute myocardial infarction (AMI). METHODS: Blood concentrations of cTnI were measured at presentation and after 1 h using four different cTnI assays: three commonly used sensitive (s-cTnI Architect, Ultra and Accu) and one experimental high-sensitivity assay (hs-cTnI Accu) in a prospective multicenter diagnostic study of patients presenting to the emergency department with suspected AMI...
June 4, 2018: International Journal of Cardiology
Hongmei Li, Yun Xing, Duomeng Yang, Xiangxu Tang, Daxiang Lu, Huadong Wang
It was demonstrated that α1 adrenergic receptor (α1-AR) activation by phenylephrine (PE) attenuated cardiac dysfunction in lipopolysaccharide (LPS) - challenged mice. However, it is unclear whether PE suppresses sepsis-induced cardiomyocyte apoptosis. Here, we investigated the effects of PE on cardiomyocyte apoptosis in LPS-treated adult rat ventricular myocytes (ARVMs) and septic rats induced by cecal ligation and puncture. Cardiomyocyte apoptosis and caspase activity were detected by TUNEL and spectrophotometrical assay, respectively...
June 8, 2018: Shock
Xin-Yi Li, Fu-Yan Feng, Xiao-Dong Zhou, Ji-Ming Hu
The pentapeptide Cys-Ala-Leu-Asn-Asn (CALNN) could stabilize gold nanoparticles (AuNPs), most of which serve as anchoring blocks for various bioanalyses by introducing recognition blocks. However, the typical conjugation strategy greatly suffers from excessive use of peptides, overnight incubation and consequently low efficiency. In this study, new design criteria for the efficacious anchor were established. In addition, a stable, instantaneous and effective modification of the anchoring peptide RRFPDD or its derivatives on AuNPs is first proposed for the first time...
June 11, 2018: Nanoscale
Dongshi Liang, Airong Huang, Yimei Jin, Miaomiao Lin, Xiaojiao Xia, Xiaoli Chen, Airong Huang
This study aimed to examine whether exogenous NaHS can protect myocardial mitochondrial injury from sepsis by enhancing the peroxisome proliferator-activated receptor gamma co-activator 1α (PGC-1α)/ nuclear factor erythroid-2-related factor 2 (NRF2) pathway and mitochondrial biosynthesis in mice. Animals were divided into sham-operated, sepsis, sepsis + 25 μmol/L NaHS, sepsis + 50 μmol/L NaHS, sepsis + 100 μmol/L NaHS, and sepsis + 200 μmol/L NaHS groups. The myocardial damage was evaluated by hematoxylin and eosin staining for myocardial microstructure and serum cardiac troponin I (cTnI) detection...
2018: American Journal of Translational Research
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