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Cardiac troponin I

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https://www.readbyqxmd.com/read/29651246/lactone-component-from-ligusticum-chuanxiong-alleviates-myocardial-ischemia-injury-through-inhibiting-autophagy
#1
Gang Wang, Guoliang Dai, Jie Song, Maomao Zhu, Ying Liu, Xuefeng Hou, Zhongcheng Ke, Yuanli Zhou, Huihui Qiu, Fujing Wang, Nan Jiang, Xiaobin Jia, Liang Feng
The dysregulation of autophagy is associated with a series of cardiovascular diseases, such as myocardial ischemia injury. Lactone component from Ligusticum chuanxiong (LLC) is the major constituent of the traditional Chinese herb L. chuanxiong Hort., which has been reported to hold potential cardioprotective effects. In this study, to determine whether LLC protects the heart through regulation of autophagy, we explored the effects of LLC on cardioprotection and autophagy in myocardial ischemia injured rats and H9c2 cardiomyocytes...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29630131/butorphanol-attenuates-myocardial-ischemia-reperfusion-injury-through-inhibiting-mitochondria-mediated-apoptosis-in-mice
#2
L-H Huang, J Li, J-P Gu, M-X Qu, J Yu, Z-Y Wang
OBJECTIVE: To investigate the role of the opioid receptors agonist butorphanol on mice myocardial ischemia reperfusion (I/R) injury. MATERIALS AND METHODS: The left anterior descending of coronary artery was ligatured for 30 min and then reperfusion for 6 h was performed to mimic the mouse myocardial I/R injury. All mice were randomly divided into three groups: sham group, I/R group and I/R + butorphanol group. Blood samples were collected for the measurement of cardiac troponin I (CTnI) and creatine kinase MB (CK-MB) levels...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29630122/analysis-of-the-correlation-between-the-neutrophil-lymphocyte-ratio-in-peripheral-blood-and-perioperative-myocardial-damage-in-pediatric-patients-with-frequent-ventricular-premature-beat
#3
J Tian, X-J An, L Niu
OBJECTIVE: The objective of the present study was to investigate the relationship between the neutrophil-lymphocyte ratio (NLR) in peripheral blood and myocardial damage in pediatric patients with frequent ventricular premature beat (FVPB), and provide a reference for myocardial preservation in these patients. PATIENTS AND METHODS: A total of 212 pediatric patients who were treated in the Department of Cardiology, Xuzhou Children's Hospital between December 2014 and March 2016 for FVPB, were selected...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29629570/modulatory-effects-of-rosemary-leaves-aqueous-extraction-against-oxidative-stress-and-related-damages-in-experimental-model-of-ccl4-induced-cardiac-toxicity-in-mice
#4
Houda Hamed, Khaled Bellassoued, Noura Brahmi, Ahmed Gargouri, Zied Ghannoudi, Abdelfattah El Feki
Rosmarinus officialis L., Lamiaceae, has been traditionally used in Tunisia to treat several diseases. The aim of the present study is to analyze the cardiopreventive effect of Aqueous Extract of Rosemary (Rosmarinus officinalis) Leaves (AERL) against oxidative stress induced by carbon tetrachloride in experimental mice. The current study was performed on female Wistar mice divided into four groups of seven animals each. Cardiotoxity was induced by a single intraperitoneal injection of CCl4 (10ml/kg in 0.3 % olive oil) in mice which were gavaged daily with 100 mg of AERL for 15 days...
April 9, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29628586/postoperative-cardiac-surgery-outcomes-in-a-statin-native-population
#5
Sameh Aboulnaga, Ahmed Mahfouz, Hesham A Ewila, Alejandro Kohn Tuli, Rajvir Singh, Amr S Omar, Abdulaziz Al Khualifi
Background: Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications. Design: This was a retrospective, descriptive, single-center study. Settings: We analyzed morbidity after cardiac surgery as well as the outcome related to statin therapy in a tertiary cardiac center. Patients: A total of 202 consecutive patients were enrolled over 1 year after cardiac surgery...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628129/comparison-of-the-association-between-high-sensitivity-troponin-i-and-adverse-cardiovascular-outcomes-in-patients-with-versus-without-chronic-kidney-disease
#6
Pratik B Sandesara, Wesley T O'Neal, Ayman Samman Tahhan, Salim S Hayek, Suegene K Lee, Jay Khambhati, Matthew L Topel, Muhammad Hammadah, Ayman Alkhoder, Yi-An Ko, Mohamad Mazen Gafeer, Agim Beshiri, Gillian Murtagh, Jonathan H Kim, Peter Wilson, Leslee Shaw, Stephen E Epstein, Laurence S Sperling, Arshed A Quyyumi
It is unknown whether the association of high-sensitivity troponin I (hs-TnI) with adverse cardiovascular outcomes varies by the presence of chronic kidney disease (CKD). We examined the association of hs-TnI with adverse cardiovascular outcomes in those with and without CKD in 4,107 (mean age, 64 years; 63% men; 20% black) patients from the Emory Cardiovascular Biobank who underwent coronary angiography. CKD (n = 1,073) was defined as estimated glomerular filtration rate <60 ml/min/1.73 m2 or urine albumin/creatinine ratio >30 mg/g at baseline...
March 14, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29622596/risk-stratifying-chest-pain-patients-in-the-emergency-department-using-heart-grace-and-timi-scores-with-a-single-contemporary-troponin-result-to-predict-major-adverse-cardiac-events
#7
Peter D W Reaney, Hamish I Elliot, Awsan Noman, Jamie G Cooper
BACKGROUND: The majority of patients presenting to the ED with cardiac sounding chest pain have a non-diagnostic ECG and the problem of differentiating those suffering an acute coronary syndrome from those without is familiar to all ED clinical staff. To stratify risk in these patients, specific scores have been developed. Recent work has focused on incorporating newer high-sensitivity cardiac troponin (hs-cTn) assays; however, issues regarding performance and availability of these assays remain...
April 5, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29622161/elevated-cardiac-troponin-t-in-patients-with-skeletal-myopathies
#8
Johannes Schmid, Laura Liesinger, Ruth Birner-Gruenberger, Tatjana Stojakovic, Hubert Scharnagl, Benjamin Dieplinger, Martin Asslaber, Roman Radl, Meinrad Beer, Malgorzata Polacin, Johannes Mair, Dieter Szolar, Andrea Berghold, Stefan Quasthoff, Josepha S Binder, Peter P Rainer
BACKGROUND: Cardiac troponins are often elevated in patients with skeletal muscle disease who have no evidence of cardiac disease. OBJECTIVES: The goal of this study was to characterize cardiac troponin concentrations in patients with myopathies and derive insights regarding the source of elevated troponin T measurements. METHODS: Cardiac troponin T (cTnT) and cardiac troponin I (cTnI) concentrations were determined by using high sensitivity assays in 74 patients with hereditary and acquired skeletal myopathies...
April 10, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29615637/%C3%AE-2a-adrenergic-blockade-attenuates-septic-cardiomyopathy-by-increasing-cardiac-norepinephrine-concentration-and-inhibiting-cardiac-endothelial-activation
#9
Xiaohui Yu, Yuan Wang, Duomeng Yang, Xiangxu Tang, Hongmei Li, Xiuxiu Lv, Renbin Qi, Chaofeng Hu, Daxiang Lu, Ben Lv, Huadong Wang
Cardiomyopathy is a common complication associated with increased mortality in sepsis, but lacks specific therapy. Here, using genetic and pharmacological approaches, we explored the therapeutic effect of α2A -adrenergic receptor (AR) blockade on septic cardiomyopathy. CLP-induced septic rats were treated with BRL44408 (α2A -AR antagonist), prazosin (α1 -AR antagonist) and/or reserpine. CLP-induced cardiomyopathy, indicated by reduced dP/dt and increased cardiac troponin I phosphorylation, was attenuated by BRL44408, this was associated with reduced cardiac TNF-α and endothelial VCAM-1 expression, cardiomyocyte apoptosis and related signal molecule phosphorylation...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615436/ttr-transthyretin-stabilizers-are-associated-with-improved-survival-in-patients-with-ttr-cardiac-amyloidosis
#10
Hannah Rosenblum, Adam Castano, Julissa Alvarez, Jeff Goldsmith, Stephen Helmke, Mathew S Maurer
BACKGROUND: TTR (transthyretin) cardiac amyloidosis is caused by dissociation of TTR into monomers, which misassemble into amyloid fibrils. TTR stabilizers act at the dimer-dimer interface to prevent dissociation. We investigated differences in survival among patients with TTR cardiac amyloidosis on stabilizer medications compared with those not on stabilizers. METHODS AND RESULTS: A retrospective study of patients with TTR cardiac amyloidosis presenting to a single center was conducted...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29611320/high-fibroblast-growth-factor-23-concentrations-in-experimental-renal-failure-impair-calcium-handling-in-cardiomyocytes
#11
Melissa Verkaik, Maarten Oranje, Desiree Abdurrachim, Max Goebel, Zeineb Gam, Jeanine J Prompers, Michiel Helmes, Pieter M Ter Wee, Jolanda van der Velden, Diederik W Kuster, Marc G Vervloet, Etto C Eringa
The overwhelming majority of patients with chronic kidney disease (CKD) die prematurely before reaching end-stage renal disease, mainly due to cardiovascular causes, of which heart failure is the predominant clinical presentation. We hypothesized that CKD-induced increases of plasma FGF23 impair cardiac diastolic and systolic function. To test this, mice were subjected to 5/6 nephrectomy (5/6Nx) or were injected with FGF23 for seven consecutive days. Six weeks after surgery, plasma FGF23 was higher in 5/6Nx mice compared to sham mice (720 ± 31 vs...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29607894/high-cardiac-troponin-i-is-associated-with-transesophageal-echocardiographic-risk-of-thromboembolism-and-ischemic-stroke-events-in-non-valvular-atrial-fibrillation-patients
#12
Shuhei Tanaka, Tadakazu Hirai, Kyoko Inao, Nobuyuki Fukuda, Keiko Nakagawa, Hiroshi Inoue, Koichiro Kinugawa
BACKGROUND: Abnormalities in the left atrium (LA) detected on transesophageal echocardiography (TEE) are reliable predictors of thromboembolism in patients with atrial fibrillation (AF). Cardiac troponin I, a marker of subclinical myocardial damage, may also be a predictor of thromboembolic events in patients with AF. The relationship between cardiac troponin I and thromboembolic risk on TEE, however, remains unclear.Methods and Results:TEE and laboratory data, including high sensitivity cardiac troponin I (hs-cTnI) and CHA2 DS2 -VASc score, were analyzed in 199 patients with non-valvular AF (NVAF)...
March 31, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29607545/effectiveness-to-identify-acute-myocardial-infarction-using-the-manchester-screening-in-patients-with-chest-pain-at-the-emergency-service
#13
Simone M Gonçalves, Karina B Gomes, Maria das G Carvalho, Henrique P B Magalhães, Edna A Reis, Iêda de Fátima O Silva
BACKGROUND: Among cardiovascular diseases (CVD), acute coronary syndrome (ACS) is the main manifestation, corresponding to signs and symptoms that occur with ischemia and outcome of angina or acute myocardial infarction (AMI). The aim of this study was to investigate the performance of biochemical markers eligible in a chest pain protocol, using Point of care Test (POCT), in patients in a reference emergency room. METHODS: In this study, 1380 medical records of patients of both genders were evaluated, ranked by applying chest pain protocol using the Manchester Triage System (MTS)...
April 2, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29600658/-protective-effect-of-dendrobium-candidum-on-isoproterenol-induced-cardiac-hypertrophy-in-rats
#14
Xiao-Chun Xiao, Wei-Hong Chen, Yuan-Yuan Cao, Yong-Jun Lou, Yuan Liu, Jin Wang, Xu-Feng Zhai, Nian-Sheng Li, Ying Li
To study the effect and mechanism of Dendrobium candidum on isoproterenol-induced myocardial hypertrophy in rats, 60 healthy SD rats(30 males and 30 females) were randomly divided into 5 groups(12 in each group): normal group, model group, three D. candidum preventive administration groups(0.09, 0.18, 1.1 g·kg⁻¹). Except for the normal group, rats of other groups were injected back subcutaneously with ISO(5 mg·kg⁻¹) for 10 consecutive days. At the same time, preventive administration groups began to give different doses of the sample for 30 days and model group began to give normal saline...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29594511/improving-the-sensitivity-of-immunoassays-by-reducing-non-specific-binding-of-poly-acrylic-acid-coated-upconverting-nanoparticles-by-adding-free-poly-acrylic-acid
#15
Satu Lahtinen, Annika Lyytikäinen, Nina Sirkka, Henna Päkkilä, Tero Soukka
Upconverting nanoparticles (UCNPs) are attractive reporters in immunoassays because of their outstanding detectability. However, non-specific binding of antibody-UCNP conjugates on protein coated solid support results in background, which limits the immunoassay sensitivity. Thus, the full potential of UCNPs as reporters cannot be fully exploited. The authors report here a method to improve the sensitivity of UCNP-based immunoassays by reducing the non-specific binding of antibody-UNCP conjugates on the protein coated solid support...
March 13, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29581813/atypical-presentation-of-acute-myeloid-leukemia
#16
Kavita Agrawal, Levin Miles, Nirav Agrawal, Asim Khan
We present a case of a 48-year-old male who presented with worsening pleuritic chest pain for 2 h. He also complained of fever, malaise, headache and severe neck pain. Electrocardiogram (ECG) showed ST segment elevation in leads I, II, aVL and V5 with PR elevation and ST depression in aVR. On admission, troponin-I was 14.8 ng/mL. Based on ECG changes, elevated troponin and family history of early coronary artery disease, the patient was emergently taken to cardiac catheterization lab. Angiography showed non-obstructive coronaries, mild hypokinesis of mid inferior and anterolateral wall with ejection fraction (EF) of 40-45%...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29581714/congenital-left-ventricular-aneurysms-and-diverticula-an-entity-in-search-of-an-identity
#17
REVIEW
Marc-Alexander Ohlow
Congenital left ventricular aneurysm or diverticulum are rare cardiac malformations described in 809 cases since the first description in 1816, being associated with other cardiac, vascular or thoraco-abdominal abnormalities in about 70%. It appears to be a developmental anomaly, starting in the 4th embryonic week. In an experimental study, targeted knockdown of cardiac troponin T in the chick was performed at day 3, after the heart tube has formed. Morpholino treatment of gene TNNT2 at this stage led to the development of left ventricular diverticula (LVD) in the primitive left ventricular wall...
December 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29580665/low-t3-syndrome-improves-risk-prediction-of-in-hospital-cardiovascular-death-in-patients-with-acute-myocardial-infarction
#18
Wen Su, Xue-Qiao Zhao, Man Wang, Hui Chen, Hong-Wei Li
BACKGROUND: Low triiodothyronine (T3) syndrome (LT3S) is frequently seen in patients with acute myocardial infarction (AMI). We examined the association between LT3S and severity of myocardial injury and determined whether LT3S adds predictive value over thrombolysis in myocardial infarction (TIMI) risk score for in-hospital cardiovascular (CV) death. METHODS: Of 2459 AMI patients, 529 pairs of euthyroid and LT3S individuals with similar baseline characteristics were identified using 1:1 propensity score matching...
March 23, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29580633/relation-of-testosterone-levels-to-mortality-in-men-with-heart-failure
#19
Akiomi Yoshihisa, Satoshi Suzuki, Yu Sato, Yuki Kanno, Satoshi Abe, Makiko Miyata, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
We aimed to investigate the impact of testosterone on the prognosis of heart failure (HF), as well as the underlying cardiac function, cardiac damage, and exercise capacity. We analyzed consecutive 618 men with HF (age 65.9 years). These patients were divided into quartiles based on their serum levels of total testosterone (TT): first (TT > 631 ng/dl, n = 154), second (462 < TT ≤ 631 ng/dl, n = 155), third (300 < TT ≤ 462 ng/dl, n = 156), and fourth (TT ≤ 300 ng/dl, n = 153) quartiles...
March 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29580629/rates-of-echocardiography-coronary-angiography-and-coronary-intervention-associated-with-troponin-testing-in-hospitalized-patients
#20
Gibbs Wilson, Kevin Kurian, Syed Zamin, Jonathan Urbanczyk, Travis Haneke, Cameron Simonsen, Sachin Mehta, Mitta Suresh, Jeffrey Michel
Diagnosis of acute myocardial infarction (AMI) often depends on detection of cardiac troponin elevation >99th percentile. However, troponin elevation is commonly found in patients without AMI. We have previously reported an association between troponin elevation and rates of electrocardiogram (ECG), echocardiography (ECHO), and coronary angiography (CAG) in patients with a primary diagnosis of sepsis. We hypothesized that elevated troponin might be associated with greater use of ECHO and CAG in primary diagnoses other than sepsis and that this correlation might also include percutaneous coronary intervention (PCI)...
March 2, 2018: American Journal of Cardiology
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