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https://www.readbyqxmd.com/read/28534570/au38cu1-2-pet-24-nanocluster-synthesis-enantioseparation-and-luminescence
#1
Rania Kazan, Bei Zhang, Thomas Bürgi
A CuAu38 bimetallic nanocluster was synthesized by adding a single copper atom to the Au38(2-PET)24 nanocluster. The absence of CuxAu38-x(2-PET)24 doped species was demonstrated by MALDI-TOF mass spectrometry. A separation of bimetallic clusters was attained for the first time where isomers of the E2 enantiomer of the Au38Cu1(2-PET)24 adduct were successfully isolated from their parent cluster using chiral HPLC. The CD of the isolated isomers revealed a change in their electronic structure upon copper addition...
May 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28534462/associations-between-alcohol-dehydrogenase-genes-and-alcohol-use-across-early-and-middle-adolescence-moderation-%C3%A3-preventive-intervention
#2
H Harrington Cleveland, Gabriel L Schlomer, David J Vandenbergh, Pedro S A Wolf, Mark E Feinberg, Mark T Greenberg, Richard L Spoth, Cleve Redmond
Data from the in-school sample of the PROSPER preventive intervention dissemination trial were used to investigate associations between alcohol dehydrogenase genes and alcohol use across adolescence, and whether substance misuse interventions in the 6th and 7th grades (targeting parenting, family functioning, social norms, youth decision making, and peer group affiliations) modified associations between these genes and adolescent use. Primary analyses were run on a sample of 1,885 individuals and included three steps...
May 23, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28534453/serotonin-functioning-and-adolescents-alcohol-use-a-genetically-informed-study-examining-mechanisms-of-risk
#3
Frances L Wang, Laurie Chassin, John E Bates, Danielle Dick, Jennifer E Lansford, Gregory S Pettit, Kenneth A Dodge
The current study used data from two longitudinal samples to test whether self-regulation, depressive symptoms, and aggression/antisociality were mediators in the relation between a polygenic score indexing serotonin (5-HT) functioning and alcohol use in adolescence. The results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create 5-HT polygenic risk scores. Adolescents and/or parents reported on adolescents' self-regulation (Time 1), depressive symptoms (Time 2), aggression/antisociality (Time 2), and alcohol use (Time 3)...
May 23, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28532504/vineland-adaptive-behavior-scales-to-identify-neurodevelopmental-problems-in-children-with-congenital-hyperinsulinism-chi
#4
Maria Salomon-Estebanez, Zainab Mohamed, Maria Michaelidou, Hannah Collins, Lindsey Rigby, Mars Skae, Raja Padidela, Stewart Rust, Mark Dunne, Karen Cosgrove, Indraneel Banerjee, Jacqueline Nicholson
BACKGROUND: Congenital Hyperinsulinism (CHI) is a disease of severe hypoglycaemia caused by excess insulin secretion and associated with adverse neurodevelopment in a third of children. The Vineland Adaptive Behavior Scales Second Edition (VABS-II) is a parent report measure of adaptive functioning that could be used as a developmental screening tool in patients with CHI. We have investigated the performance of VABS-II as a screening tool to identify developmental delay in a relatively large cohort of children with CHI...
May 22, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28531273/phenotypes-of-atopic-dermatitis-depending-on-the-timing-of-onset-and-progression-in-childhood
#5
Caroline Roduit, Remo Frei, Martin Depner, Anne M Karvonen, Harald Renz, Charlotte Braun-Fahrländer, Elisabeth Schmausser-Hechfellner, Juha Pekkanen, Josef Riedler, Jean-Charles Dalphin, Erika von Mutius, Roger Pascal Lauener, Anne Hyvärinen, Pirkka Kirjavainen, Sami Remes, Marjut Roponen, Marie-Laure Dalphin, Vincent Kaulek, Markus Ege, Jon Genuneit, Sabina Illi, Micahel Kabesch, Bianca Schaub, Petra Ina Pfefferle, Gert Doekes
Importance: Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking. Objective: To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases...
May 22, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28523849/validation-of-a-parent-reported-diagnostic-instrument-in-a-u-s-referral-population-the-childhood-eczema-questionnaire
#6
Sabra Leitenberger, Tamar Hajar, Eric L Simpson, Laura von Kobyletzki, Jon M Hanifin
BACKGROUND/OBJECTIVES: There is a paucity of validated tools for diagnosing atopic dermatitis (AD) in very young children that do not rely on clinical evaluation. The Childhood Eczema Questionnaire (CEQ)-a diagnostic tool for AD in children younger than 2 years that a caretaker can complete-was recently validated in Sweden. The objective of this study was to validate the tool in a U.S. POPULATION: As a substudy, we added an additional question that was independently assessed...
May 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28516851/intimate-partner-abuse-and-attachment-a-comparison-between-abused-and-nonabused-women
#7
M Meghan Davidson, Michael S Butchko, Janice E Castro, Krista Robbins
The purpose of this study was to examine intimate partner abuse (IPA), parental attachment, and romantic attachment among college women. More specifically, IPA was examined such that women who had experienced abuse and those who had not were compared with respect to parental and romantic attachment using the lens of attachment theory. Undergraduate women (N = 502) completed an online survey assessing their experiences of IPA as well as their parental and romantic attachment styles. Bivariate correlations demonstrated that IPA was significantly associated with all study variables (i...
May 17, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28516834/comparison-of-antemortem-and-environmental-samples-for-zebrafish-health-monitoring-and-quarantine
#8
Marcus J Crim, Christian Lawrence, Robert S Livingston, Andrei Rakitin, Shane J Hurley, Lela K Riley
Molecular diagnostic assays offer both exquisite sensitivity and the ability to test a wide variety of sample types. Varioustypes of environmental sample, such as detritus and concentrated water, might provide a useful adjunct to sentinels in routinezebrafish health monitoring. Similarly, antemortem sampling would be advantageous for expediting zebrafish quarantine,without euthanasia of valuable fish. We evaluated the detection of Mycobacterium chelonae, M. fortuitum, M. peregrinum,Pseudocapillaria tomentosa, and Pseudoloma neurophilia in zebrafish, detritus, pooled feces, and filter membranes after filtration of 1000-, 500-, and 150-mL water samples by real-time PCR analysis...
May 17, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28499112/polygenic-risk-personality-dimensions-and-adolescent-alcohol-use-problems-a-longitudinal-study
#9
James J Li, Jeanne E Savage, Kenneth S Kendler, Matthew Hickman, Liam Mahedy, John Macleod, Jaakko Kaprio, Richard J Rose, Danielle M Dick
OBJECTIVE: Alcohol use problems are common during adolescence and can predict serious negative outcomes in adulthood, including substance dependence and psychopathology. The current study examines the notion that alcohol use problems are driven by polygenic influences and that genetic influences may indirectly affect alcohol use problems through multiple pathways of risk, including variations in personality. METHOD: We used a genome-wide approach to examine associations between genetic risk for alcohol use problems, personality dimensions, and adolescent alcohol use problems in two separate longitudinal population-based samples, the Finnish Twin Cohort (FinnTwin12) and the Avon Longitudinal Study of Parents and Children (ALSPAC)...
May 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28494910/the-effects-of-maternal-presence-during-anesthesia-induction-on-salivary-cortisol-levels-in-children-undergoing-tonsillectomy-and-or-adenoidectomy
#10
Hatice K Ozdogan, Sibel Cetinalp, Gokhan Kuran, Onder Tugal, Murat Tahiroglu, Ummuhan E Herdem, Suheyl Haytoglu
OBJECTIVE: Although parental presence during anesthesia induction is suggested to diminish operative stress level in children, there have been conflicting results about this strategy. The aim of this study was to evaluate the effects of maternal presence during induction on operative stress level in children who had tonsillectomy and/or adenoidectomy by determining the salivary cortisol levels. DESIGN: Non-randomized clinical study. SETTING: Preoperative and postoperative recovery rooms, operating room...
June 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28492333/self-assembly-of-amphiphilic-biotransesterified-%C3%AE-cyclodextrins-supramolecular-structure-of-nanoparticles-and-surface-properties
#11
Jean-Luc Putaux, Christine Lancelon-Pin, Francois-Xavier Legrand, Marion Pastrello, Luc Choisnard, Annabelle Geze, Cyrille Rochas, Denis Wouessidjewe
A series of β-cyclodextrin (βCD) amphiphilic derivatives with varying degree of substitution was prepared by acylating βCDs on their secondary face using thermolysin to catalyze the transesterification. After dissolution in acetone, the βCD-Cn derivatives (n = 8, 10, 12, 14) were nanoprecipitated in water where they self-organized into structured particles which were characterized using cryo-transmission electron microscopy (cryo-TEM) images and small-angle X-ray scattering (SAXS) data. Two types of morphologies and ultrastructures were observed depending on the total degree of substitution (TDS) of the parent derivative...
May 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28490831/parental-separation-and-school-performance-among-children-of-immigrant-mothers-in-sweden
#12
Jeylan Erman, Juho Härkönen
Immigration and family change are two demographic processes that have changed the face of European societies and are associated with inequalities in child outcomes. Yet there is little research outside the USA on whether the effects of family dynamics on children's life chances vary by immigrant background. We asked whether the effect of parental separation on educational achievement varies between immigrant backgrounds (ancestries) in Sweden. We used Swedish population register data on two birth cohorts (born in 1995 and 1996) of Swedish-born children and analyzed parental separation penalties on grade sums and non-passing grades (measured at ninth grade) across ten ancestry groups, defined by the mother's country of birth...
2017: European Journal of Population
https://www.readbyqxmd.com/read/28490830/explaining-conflicting-results-in-research-on-the-heterogeneous-effects-of-parental-separation-on-children-s-educational-attainment-according-to-social-background
#13
Fabrizio Bernardi, Diederik Boertien
In recent years, researchers have become increasingly interested in how the effects of parental separation on children's educational attainment vary with social background. On the one hand, parents with more resources might be better able to prevent possible adverse events like separation to affect their children's outcomes. On the other hand, children from higher social backgrounds might have more resources to lose from a parental separation. A wide range of empirical studies on the issue have come to inconsistent conclusions, with support found for both perspectives...
2017: European Journal of Population
https://www.readbyqxmd.com/read/28488902/designing-augmentative-and-alternative-communication-applications-the-results-of-focus-groups-with-speech-language-pathologists-and-parents-of-children-with-autism-spectrum-disorder
#14
Jamie B Boster, John W McCarthy
PURPOSE: The purpose of this study was to gain insight from speech-language pathologists (SLPs) and parents of children with autism spectrum disorder (ASD) regarding appealing features of augmentative and alternative communication (AAC) applications. METHOD: Two separate 1-hour focus groups were conducted with 8 SLPs and 5 parents of children with ASD to identify appealing design features of AAC Apps, their benefits and potential concerns. Participants were shown novel interface designs for communication mode, play mode and incentive systems...
May 10, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28488289/adversity-and-resilience-amongst-resettling-western-australian-paediatric-refugees
#15
Gemma Hanes, Lydia Sung, Raewyn Mutch, Sarah Cherian
AIM: Cumulative adverse childhood experiences have long-term consequences and may manifest within and influence health, educational and psychosocial domains. The Princess Margaret Hospital Refugee Health Service (RHS) undertakes multidisciplinary screening of refugee children <16 years, allowing standardised identification of negative childhood experiences. Addition of the extended Strengths and Difficulties Questionnaire (SDQ) in 2014 aimed to augment psychological assessment of this cohort...
May 10, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28486098/preparation-of-212-pb-labeled-monoclonal-antibody-using-a-novel-224-ra-based-generator-solution
#16
Sara Westrøm, Roman Generalov, Tina B Bønsdorff, Roy H Larsen
INTRODUCTION: Alpha-emitting radionuclides have gained considerable attention as payloads for cancer targeting molecules due to their high cytotoxicity. One attractive radionuclide for this purpose is (212)Pb, which by itself is a β-emitter, but acts as an in vivo generator for its short-lived α-emitting daughters. The standard method of preparing (212)Pb-labeled antibodies requires handling and evaporation of strong acids containing high radioactivity levels by the end user. An operationally easier and more rapid process could be useful since the 10...
April 26, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28485775/determination-of-phloroglucinol-by-hplc-ms-ms-and-its-application-to-a-bioequivalence-study-in-healthy-volunteers
#17
X-Q Li, R-T Wang, Q-H Wang, X-L Tang, C-T Lu, H-G Gong, A-D Wen
OBJECTIVE: The aim of this study was to compare the pharmacokinetic characteristics of phloroglucinol between an orally disintegrating tablet and an orally lyophilized tablet of phloroglucinol in healthy volunteers under fasting condition. PATIENTS AND METHODS: A rapid and simple method based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method has been developed and validated for the determination of phloroglucinol in human plasma...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28480146/development-and-application-of-14-microsatellite-markers-in-the-burying-beetle-nicrophorus-vespilloides-reveals-population-genetic-differentiation-at-local-spatial-scales
#18
Sonia Pascoal, Rebecca M Kilner
Burying beetles (genus Nicrophorus) are relatively rare among insects in providing sophisticated parental care. Consequently, they have become model species in research analysing social evolution, the evolution of parental care and mating systems. We used the recently published N. vespilloides genome and transcriptome to develop microsatellite markers. Specifically, we developed 14 polymorphic markers with five to 13 alleles per locus and used them to investigate levels of genetic differentiation in four south Cambridgeshire (UK) populations of N...
2017: PeerJ
https://www.readbyqxmd.com/read/28478764/stability-and-change-in-dietary-scores-and-patterns-across-six-waves-of-the-longitudinal-study-of-australian-children
#19
Constantine E Gasser, Jessica A Kerr, Fiona K Mensah, Melissa Wake
This study aimed to derive and compare longitudinal trajectories of dietary scores and patterns from 2-3 to 10-11 years and from 4-5 to 14-15 years of age. In waves two to six of the Baby (B) Cohort and one to six of the Kindergarten (K) Cohort of the population-based Longitudinal Study of Australian Children, parents or children reported biennially on the study child's consumption of twelve to sixteen healthy and less healthy food or drink items for the previous 24 h. For each wave, we derived a dietary score from 0 to 14, based on the 2013 Australian Dietary Guidelines (higher scores indicating healthier diet)...
May 8, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28474277/religion-spirituality-and-folk-medicine-superstition-in-a-neonatal-unit
#20
Jose María Lloreda-Garcia
Beliefs and practices surrounding religion and spirituality (RS) feature in neonatal units, although healthcare professionals and families hold different views on their role in neonatal care. Descriptive study performed at the Neonatology Unit of Santa Lucía University Hospital, Cartagena. Separate forms concerning spirituality, religion and folk medicine were administered to professionals ascribed to the unit (n = 70) and parents (n = 93). 70% of professionals and 60.2% of parents perceive RS as playing a relevant role in neonatal care; however, 45% of professionals prefer that parents do not express their RS beliefs...
May 4, 2017: Journal of Religion and Health
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