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https://www.readbyqxmd.com/read/29783825/-clinical-and-molecular-analysis-of-two-chinese-siblings-with-bloom-syndrome
#1
M L Wu, X M Wang, J Li, Y Ding, Y Chen, G Y Chang, J Wang, Y P Shen
Objective: To expand the knowledge of the clinical and molecular characteristics of the children with Bloom syndrome. Methods: Clinical data of two siblings with classic Bloom syndrome of Shanghai Children's Medical Center from January 2009 to June 2017 were obtained and analyzed. The DNA of peripheral blood was collected from two Bloom syndrome siblings and their parents during 2015. The mutations were detected with high-throughput sequencing by Illumina sequencing platform. Results: The two siblings (probands) visited our department for short stature and growth retardation, they had full-term normal delivery after normal pregnancy of their mother...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29783173/development-and-validation-of-an-analytical-method-for-regorafenib-and-its-metabolites-in-mouse-plasma
#2
Qiang Fu, Mingqing Chen, Shuiying Hu, Craig A McElroy, Ron H Mathijssen, Alex Sparreboom, Sharyn D Baker
An analytical method was developed for measuring the effect of OATP1B2 deficiency on plasma levels of the kinase inhibitor regorafenib and its metabolites regorafenib-N-oxide, N-desmethyl-regorafenib-N-oxide, and regorafenib-N-β-glucuronide (RG) in mice. Compounds were separated by liquid chromatography and monitored by a triple quadrupole mass spectrometer in the selected reaction monitoring mode after positive electrospray ionization. All calibration curves were linear in the selected concentration range (R2  ≥ 0...
May 5, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29782508/parent-and-caregiver-perceptions-about-the-safety-and-effectiveness-of-foreign-and-domestic-vaccines-in-shanghai-china
#3
Zhuoying Huang, Xiaodong Sun, Abram L Wagner, Jia Ren, Matthew L Boulton, Lisa A Prosser, Brian J Zikmund-Fisher
BACKGROUND: Chinese parents have access to domestic and foreign vaccines for their children. Their vaccine preferences are unclear, especially given recent pharmaceutical quality scandals and widely held beliefs deriving from Traditional Chinese Medicine (TCM). This study characterized parental beliefs about the safety and effectiveness of Chinese and foreign vaccines. METHODS: In May 2014, caregivers of young children at public immunization clinics in Shanghai, China, responded to a survey on vaccine perceptions...
2018: PloS One
https://www.readbyqxmd.com/read/29781667/re-examination-of-the-family-law-detection-of-overall-risk-screen-fl-doors-establishing-fitness-for-purpose
#4
Yvonne Wells, Jamie Lee, Xia Li, Evelyn S Tan, Jennifer E McIntosh
Conflicted parental separation is associated with escalating risks to wellbeing and safety for all family members. The Family Law DOORS (FL-DOORS, Detection Of Overall Risk Screen) is a three-part framework designed to assist frontline workers to identify, evaluate, and respond to these risks in separated families. The FL-DOORS system includes a 10-domain parent self-report screening measure, covering child and parent wellbeing, cultural and social risks, and safety risks experienced by and initiated by each parent...
May 21, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29778518/an-innovative-medical-school-curriculum-to-address-human-papillomavirus-vaccine-hesitancy
#5
Abigail M Schnaith, Erica M Evans, Caleb Vogt, Andrea M Tinsay, Thomas E Schmidt, Katelyn M Tessier, Britt K Erickson
BACKGROUND: Vaccination rates against Human Papillomavirus (HPV) in the US remain alarmingly low. Physicians can significantly influence a parent's decision to vaccinate their children. However, medical education often lacks training on specific strategies for communicating with vaccine hesitant parents. METHODS: We created an innovative curriculum designed to teach medical students how to address HPV vaccine hesitancy. The curriculum consisted of (1) a presentation on the epidemiology, biology, and disease morbidity associated with HPV, (2) a video that teaches specific communication strategies and (3) role-playing simulations...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29775870/adverse-and-adaptive-childhood-experiences-are-associated-with-parental-reflective-functioning-in-mothers-with-substance-use-disorder
#6
Ulrika Håkansson, Reidulf Watten, Kerstin Söderström, Finn Skårderud, Merete Glenne Øie
Mothers with a substance use disorder (SUD) are at risk for maladaptive parenting practices, and have heightened likelihood of having experienced childhood adversity themselves. In addition, parental reflective functioning (PRF), a capacity underlying sensitive caregiving, is often low in mothers with SUD. This study examines the relationship between PRF and aversive (emotional, physical, sexual abuse and neglect) and adaptive (safety and competence) experiences, in different developmental phases (early childhood, latency, and adolescence) in mothers with a SUD...
May 15, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29774962/maternal-regulation-of-the-infant-s-hpa-axis-stress-response-seymour-gig-levine-s-legacy-to-neuroendocrinology
#7
REVIEW
Deborah Suchecki
Thirty years ago, Seymour 'Gig' Levine published a serendipitous, yet, seminal finding on the regulatory role of maternal presence on the corticosterone stress response of neonatal rats, during the developmental period know as stress hyporesponsive period. At the same time, his group of students also studied the stress response of infant monkeys to maternal separation, as a means to understand the stressful nature of disruptions of attachment to the primary caregiver. Gig and his group of students and collaborators, mainly in the USA and the Netherlands, investigated how initial social relationships buffer the stress response of non-human primate and rodent infants...
May 18, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29770761/low-birth-weight-is-associated-with-increased-fat-intake-in-school-aged-boys
#8
Adrianne R Bischoff, André K Portella, Catherine Paquet, Roberta Dalle Molle, Aida Faber, Narendra Arora, Robert D Levitan, Patrícia P Silveira, Laurette Dube
Evidence suggests that both high and low birth weight children have increased the risk for obesity and the metabolic syndrome in adulthood. Previously we have found altered feeding behaviour and food preferences in pre-school children and adults born with low birth weight. In this study, we investigated if birth weight was associated with different intake of fat, carbohydrate and/or protein at 6-12 years of age. This is a cross-sectional study where 255 guardians answered online and telephone questions including anthropometrics and demographic data, parental family food rules (food control, encouragement and restriction) and a complete web-based FFQ for their children (130 boys and 125 girls)...
June 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29769242/implementing-parental-tobacco-dependence-treatment-within-bronchiolitis-qi-collaboratives
#9
Susan C Walley, Grant M Mussman, Michele Lossius, Kristin A Shadman, Lauren Destino, Matthew Garber, Shawn L Ralston
BACKGROUND AND OBJECTIVES: We sought to implement systematic tobacco dependence interventions for parents and/or caregivers as secondary aims within 2 multisite quality improvement (QI) collaboratives for bronchiolitis. We hypothesized that iterative improvements in tobacco dependence intervention strategies would result in improvement in outcomes between collaboratives. METHODS: This study involved 2 separate yearlong, multisite QI collaboratives that were focused on care provided to inpatients with a primary diagnosis of bronchiolitis...
May 16, 2018: Pediatrics
https://www.readbyqxmd.com/read/29769053/understanding-conversations-about-alcohol-between-parents-and-their-15-17-year-olds-a-qualitative-study
#10
Alexandra Sawyer, Lester Coleman, Richard Cooke, Lisa Hodgson, Nigel Sherriff
BACKGROUND: There is an increasing awareness that parents can play an important role in shaping their children's attitudes towards alcohol and use of alcohol. However, there has been little research exploring the conversations parents have with their children about alcohol. The present study aims to address this gap by exploring conversations between parents and their 15-17 year old children. METHODS: Using a cross-sectional qualitative design, recruitment took place over two phases to allow a purposive maximum variation sample of parents and young people...
May 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29766221/tracking-emerging-mycotoxins-in-food-development-of-an-lc-ms-ms-method-for-free-and-modified-alternaria-toxins
#11
Hannes Puntscher, Mary-Liis Kütt, Philipp Skrinjar, Hannes Mikula, Joachim Podlech, Johannes Fröhlich, Doris Marko, Benedikt Warth
Mycotoxins produced by Alternaria fungi are ubiquitous food contaminants, but analytical methods for generating comprehensive exposure data are rare. We describe the development of an LC-MS/MS method covering 17 toxins for investigating the natural occurrence of free and modified Alternaria toxins in tomato sauce, sunflower seed oil, and wheat flour. Target analytes included alternariol (AOH), AOH-3-glucoside, AOH-9-glucoside, AOH-3-sulfate, alternariol monomethyl ether (AME), AME-3-glucoside, AME-3-sulfate, altenuene, isoaltenuene, tenuazonic acid (TeA), tentoxin (TEN), altertoxin I and II, alterperylenol, stemphyltoxin III, altenusin, and altenuic acid III...
May 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29761836/acceptability-and-caregiver-reported-outcomes-for-young-children-with-autism-spectrum-disorder-whose-parents-attended-a-preventative-population-based-intervention-for-anxiety-a-pilot-study
#12
Natalie L Bischof, Ronald M Rapee, Kristelle Hudry, Jordana K Bayer
This pilot study explored acceptability to parents and outcomes for children of a preventive intervention for anxiety problems in pre-schoolers with autism spectrum disorder (ASD) who were an identified sub-group within a population-based randomised trial of the Cool Little Kids parenting group programme. The population trial included 545 temperamentally inhibited pre-schoolers recruited across eight economically diverse areas of Melbourne, Australia. Within this sample, 26 parents reported that their child had received an ASD diagnosis...
May 15, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29761415/effects-of-genetic-distance-on-heterosis-in-a-drosophila-melanogaster-model-system
#13
Charlotte Jensen, Michael Ørsted, Torsten Nygaard Kristensen
Habitat fragmentation and small population sizes can lead to inbreeding and loss of genetic variation, which can potentially cause inbreeding depression and decrease the ability of populations to adapt to altered environmental conditions. One solution to these genetic problems is the implementation of genetic rescue, which re-establishes gene flow between separated populations. Similar techniques are being used in animal and plant breeding to produce superior production animals and plants. To optimize fitness benefits in genetic rescue programs and to secure high yielding domestic varieties in animal and plant breeding, knowledge on the genetic relatedness of populations being crossed is imperative...
May 14, 2018: Genetica
https://www.readbyqxmd.com/read/29760428/generation-and-characterisation-of-a-parkin-pacrg-knockout-mouse-line-and-a-pacrg-knockout-mouse-line
#14
Sarah E M Stephenson, Timothy D Aumann, Juliet M Taylor, Jessica R Riseley, Ruili Li, Jeffrey R Mann, Doris Tomas, Paul J Lockhart
Mutations in PARK2 (parkin) can result in Parkinson's disease (PD). Parkin shares a bidirectional promoter with parkin coregulated gene (PACRG) and the transcriptional start sites are separated by only ~200 bp. Bidirectionally regulated genes have been shown to function in common biological pathways. Mice lacking parkin have largely failed to recapitulate the dopaminergic neuronal loss and movement impairments seen in individuals with parkin-mediated PD. We aimed to investigate the function of PACRG and test the hypothesis that parkin and PACRG function in a common pathway by generating and characterizing two novel knockout mouse lines harbouring loss of both parkin and Pacrg or Pacrg alone...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29757620/separation-of-protactinium-employing-sulfur-based-extraction-chromatographic-resins
#15
Tara Mastren, Benjamin W Stein, T Gannon Parker, Valery Radchenko, Roy Copping, Allison Owens, Lance E Wyant, Mark Brugh, Stosh A Kozimor, F Meiring Nortier, Eva R Birnbaum, Kevin D John, Michael Ernst-Heinrich Fassbender
Protactinium-230 (t1/2 17.4 d) is the parent isotope of 230U (t1/2 20.8 d), a radionuclide of interest for targeted alpha therapy (TAT). Column chromatographic methods have been developed to separate no-carrier-added 230Pa from proton irradiated thorium targets and accompanying fission products. Results reported within demonstrate the use of novel sulfur bearing chromatographic extraction resins for the selective separation of protactinium. The recovery yield of 230Pa was 93 ± 4 % employing a R3P=S type commercially available resin and 88 ± 4 % employing a DGTA (diglycothioamide) containing custom synthesized extraction chromatographic resin...
May 14, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29755610/the-living-conditions-of-children-with-shared-residence-the-swedish-example
#16
Emma Fransson, Sara Brolin Låftman, Viveca Östberg, Anders Hjern, Malin Bergström
Among children with separated parents, shared residence - i.e., joint physical custody where the child is sharing his or her time equally between two custodial parents' homes - is increasing in many Western countries and is particularly common in Sweden. The overall level of living among children in Sweden is high; however, the potential structural differences between children in various post-separation family arrangements have not been sufficiently studied. Potential risks for children with shared residence relate to the daily hassles and stress when having two homes...
2018: Child Indicators Research
https://www.readbyqxmd.com/read/29755248/maternal-and-paternal-predictors-of-child-depressive-symptoms-an-actor-partner-interdependence-framework
#17
Kyle W Murdock, Laura D Pittman, Christopher P Fagundes
Family members are theorized to influence each other via transactional or systems related processes; however, the literature is limited given its focus on mother-child relationships and the utilization of statistical approaches that do not model interdependence within family members. The current study evaluated associations between self-reported parental affect, parenting behavior, and child depressive symptoms among 103 mother-father-child triads. Children ranged in age from 8 to 12 years. Higher maternal negative affect was associated with greater maternal and paternal harsh/negative parenting behavior...
February 2018: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29753211/lc-ms-ms-method-for-determination-of-cyclin-dependent-kinase-inhibitors-bp-14-and-bp-20-and-its-application-in-pharmacokinetic-study-in-rat
#18
Jitka Široká, Martina Čečková, Lubor Urbánek, Vladimír Kryštof, Tomáš Gucký, Jakub Hofman, Miroslav Strnad, František Štaud
N2 -(4-Amino-cyclohexyl)-9-cyclopentyl-N6 -(6-furan-2-yl-pyridine-3-ylmethyl)-9H-purine-2,6-diamine (BP-14) and 2-(5-{[2-(4-amino-cyclohexylamino)-9-cyclopentyl-9H-purine-6-ylamino]-methyl}-pyridine-2-yl)-phenol (BP-20) are novel cyclin-dependent kinase inhibitors, structurally related to roscovitine, with significant biological activity. A simple, selective and sensitive liquid chromatography - tandem mass spectrometry method for determining them in rat plasma, using roscovitine as an internal standard, was developed and validated...
May 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29750858/a-mof-with-cooperative-phosphines-that-permits-post-synthetic-installation-of-open-metal-sites
#19
Samuel G Dunning, Gianne Nandra, Adam D Conn, Wenrui Chai, R Eric Sikma, Ji-Sung Lee, Pranaw Kunal, Joseph E Reynolds Iii, Jong-San Chang, Alexander Steiner, Graeme Henkelman, Simon Michael Humphrey
PCM-101 is a new phosphine coordination material comprised of tris(p-carboxylato)triphenylphosphine and secondary pillaring groups coordinated to [M3(OH)]5+ nodes (M = Co, Ni). PCM-101 has a unique topology in which R3P: sites are arranged directly trans- to one another, with a P···P separation distance dictated by the pillars. Post-synthetic coordination of soft metals to the P: sites proceeds at room temperature to provide X-ray quality crystals that permit full structural resolution. Addition of AuCl groups forces a large distortion of the parent framework...
May 11, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29743153/integrated-models-of-care-for-people-living-with-hepatitis-c-virus-and-a-substance-use-disorder-protocol-for-a-systematic-review
#20
Lianping Ti, Stephanie Parent, María Eugenia Socías
BACKGROUND: People living with a substance use disorder (SUD) are a key population within the hepatitis C virus (HCV) epidemic. While integrated and community-based models of care have shown positive outcomes among this population, the literature has been primarily focused on the HIV context. This paper outlines a systematic review protocol on the impact of various integrated models of care, which includes HCV and SUD services, on various treatment, and health-related outcomes among this population...
May 9, 2018: JMIR Research Protocols
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