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https://www.readbyqxmd.com/read/28100529/children-and-parental-anxiolysis-in-paediatric-ambulatory-surgery-a-randomized-controlled-study-comparing-0-3%C3%A2-mg-kg-1-midazolam-to-tablet-computer-based-interactive-distraction
#1
C Marechal, J Berthiller, S Tosetti, B Cogniat, H Desombres, L Bouvet, B Kassai, D Chassard, M de Queiroz Siqueira
BACKGROUND: The operating theatre, anaesthesia induction and separation from parents create fear and anxiety in children. Anxiety leads to adverse behavioral changes appearing and sometimes persisting during the postoperative period. Our aim was to compare the effects of midazolam (0.3 mg kg(-)(1): MDZ) for premedication with age-appropriate tablet game apps (TAB) on children anxiety during and after ambulatory surgery. METHODS: A randomized controlled trial was conducted from May 16th, 2013 to March 25th, 2014 at the Children Hospital of Lyon...
February 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28097478/study-of-the-influence-of-formulation-variables-in-bioadhesive-emulgels-using-response-surface-methodology
#2
Ana Ochoa-Andrade, M Emma Parente, Álvaro Jimenez-Kairuz, Lucía Boinbaser, Annibal Torregrosa
The aim of the present work was to study the main formulation variables that influence attributes of bioadhesive emulgels based on a combination of polymers, using response surface methodology (RSM). Bioadhesive products continue to gain attention in topical cutaneous administration as they allow long residence times on the application site, which is important when a long dermal action and a reduced product administration frequency are desired. A Box-Behnken design of experiments (DoE) was introduced to study the effect of formulation variables on quality attributes of the emulgels...
January 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28096453/programmable-formation-of-catalytic-rna-triangles-and-squares-by-assembling-modular-rna-enzymes
#3
Hiroki Oi, Daisuke Fujita, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, Shigeyoshi Matsumura, Yoshiya Ikawa
RNA is a biopolymer that is attractive for constructing nanoscale objects with complex structures. Three-dimensional (3D) structures of naturally occurring RNAs often have modular architectures. The 3D structure of a group I (GI) ribozyme from Tetrahymena has a typical modular architecture, which can be separated into two structural modules (ΔP5 and P5abc). The fully active ribozyme can be reconstructed by assembling the two separately prepared modules through highly specific and strong assembly between ΔP5 ribozyme and P5abc RNA...
January 17, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28092428/reproducibility-of-clinical-events-adjudications-in-a-trial-of-venous-thromboembolism-prevention
#4
P Girard, A Penaloza, F Parent, B Gable, O Sanchez, P Durieux, P Hausfater, S Dambrine, G Meyer, P-M Roy
BACKGROUND: When clinical trials use clinical endpoints, establishing independent Clinical Events Committees (CEC) is recommended to homogenize the interpretation of investigators data. However, the reproducibility of CEC adjudications is almost unexplored. OBJECTIVES: To assess the reproducibility of CEC adjudications in a trial of venous thromboembolism (VTE) prevention. METHODS: The PREVENU study, a multicenter trial of VTE prevention, included 15,351 hospitalized medical patients...
January 16, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28092060/parenting-self-efficacy-parent-depression-and-healthy-childhood-behaviors-in-a-low-income-minority-population-a-cross-sectional-analysis
#5
William J Heerman, Julie Lounds Taylor, Kenneth A Wallston, Shari L Barkin
Objectives Childhood obesity prevention and treatment depends, in part, on parents acting as agents of change for their children. Our objective was to measure the associations between parenting self-efficacy, parent depressive symptoms, and preschool child behaviors that support healthy growth. Methods We performed a cross-sectional analysis of baseline data from a randomized controlled trial. Parenting self-efficacy was measured using a 5-item version of the Parenting Sense of Competence (PSOC-5) scale (α= 0...
January 13, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28090349/the-association-between-parental-separation-during-childhood-and-obesity-in-adulthood-a-danish-twin-study
#6
J D Petersen, K O Kyvik, B L Heitmann, M E Vámosi
OBJECTIVE: The purpose of this study was to examine if parental separation during childhood is associated with obesity in adulthood. METHODS: A co-twin case-control study of 146 adult same-sexed twin pairs with discordant body mass index (BMI) (i.e. one of the twins should have a BMI of 20-25 kg/m(2), and the co-twin's BMI ≥ 30 kg/m(2)) was selected from Danish Twin Registry (DTR). In total of 236 eligible twin individuals participated in the study. Childhood parental separation (defined as separation from one of the biological parents, regardless of the reason for separation) for at least one year prior to age 17 was self-reported...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28090084/limiting-parental-feedback-disrupts-vocal-development-in-marmoset-monkeys
#7
Yasemin B Gultekin, Steffen R Hage
Vocalizations of human infants undergo dramatic changes across the first year by becoming increasingly mature and speech-like. Human vocal development is partially dependent on learning by imitation through social feedback between infants and caregivers. Recent studies revealed similar developmental processes being influenced by parental feedback in marmoset monkeys for apparently innate vocalizations. Marmosets produce infant-specific vocalizations that disappear after the first postnatal months. However, it is yet unclear whether parental feedback is an obligate requirement for proper vocal development...
January 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28089774/rootletin-prevents-cep68-from-vhl-mediated-proteasomal-degradation-to-maintain-centrosome-cohesion
#8
Huilong Yin, Lu Zheng, Weixiao Liu, Dachuan Zhang, Wei Li, Li Yuan
Centrosome cohesion, mostly regarded as a proteinaceous linker between parental centrioles, ensures the interphase centrosome(s) to function as a single microtubule-organizing center. Maintenance of centrosome cohesion counts on a number of centrosomal linker proteins because depletion of any of those leads to premature centrosome separation in interphase, termed centrosome splitting. However, the underlying mechanisms of the dependence are unknown. Here, we show that absence of Rootletin triggers the von Hippel-Lindau tumour suppressor protein (VHL)-mediated proteasomal degradation of Cep68 and, in turn, results in centrosome splitting...
January 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28080998/determination-of-oxycodone-and-its-major-metabolites-noroxycodone-and-oxymorphone-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-in-plasma-and-urine-application-to-real-cases
#9
Flaminia Pantano, Stefano Brauneis, Alexandre Forneris, Roberta Pacifici, Enrico Marinelli, Chrystalla Kyriakou, Simona Pichini, Francesco Paolo Busardò
BACKGROUND: Oxycodone is a narcotic drug widely used to alleviate moderate and severe acute and chronic pain. Variability in analgesic efficacy could be explained by inter-subject variations in plasma concentrations of parent drug and its active metabolite, oxymorphone. To evaluate patient compliance and to set up therapeutic drug monitoring (TDM), an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) assay was developed and validated for the parent drug and its major metabolites noroxycodone and oxymorphone...
January 12, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28079611/it-is-just-attention-deficit-hyperactivity-disorder%C3%A2-or-is-it
#10
Dana C Won, Christian Guilleminault, Peter J Koltai, Stacey D Quo, Martin T Stein, Irene M Loe
Carly is a 5-year-old girl who presents for an interdisciplinary evaluation due to behaviors at school and home suggestive of attention-deficit hyperactivity disorder (ADHD). Parent report of preschool teacher concerns was consistent with ADHD. Psychological testing showed verbal, visual-spatial, and fluid reasoning IQ scores in the average range; processing speed and working memory were below average. Carly's behavior improved when her mother left the room, and she was attentive during testing with a psychologist...
January 10, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28077178/ptsd-or-not-ptsd-comparing-the-proposed-icd-11-and-the-dsm-5-ptsd-criteria-among-young-survivors-of-the-2011-norway-attacks-and-their-parents
#11
G S Hafstad, S Thoresen, T Wentzel-Larsen, A Maercker, G Dyb
BACKGROUND: The conceptualization of post-traumatic stress disorder (PTSD) in the upcoming International Classification of Diseases (ICD)-11 differs in many respects from the diagnostic criteria in the Diagnostic and Statistical Manual for Mental Disorders, fifth edition (DSM-5). The consequences of these differences for individuals and for estimation of prevalence rates are largely unknown. This study investigated the concordance of the two diagnostic systems in two separate samples at two separate waves...
January 12, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28076344/qualitative-aspects-of-the-process-of-neonatal-hearing-screening-program-in-mexico-evaluated-from-the-parental-perspective
#12
Maria Del Consuelo Martínez Wbaldo, María de Los Ángeles Torres Lagunas
INTRODUCTION: The Universal Newborn Hearing Screening Program in Mexico began in 2010. Its results, published in 2013 by the National Council for the Development and Inclusion of Persons with Disabilities (CONADIS), report low coverage and, currently, there is a dearth of information about its activities. This study describes the process of the program from the epistemological perspective of women whose children participated in the program, evaluating it under the sustenance of the constructivist-respondent model in search of aspects that could help explain its results...
December 12, 2016: Medwave
https://www.readbyqxmd.com/read/28075619/role-of-ct-in-the-diagnosis-of-nonspecific-abdominal-pain-a-multicenter-analysis
#13
Jonathan D Eisenberg, Andrew T Reisner, William D Binder, Atif Zaheer, Martin L Gunn, Ken F Linnau, Chad M Miller, Angela C Tramontano, Maurice S Herring, Emily C Dowling, Elkan F Halpern, Karen Donelan, G Scott Gazelle, Pari V Pandharipande
OBJECTIVE: The objective of our study was to determine whether specific patient and physician factors-known before CT-are associated with a diagnosis of nonspecific abdominal pain (NSAP) after CT in the emergency department (ED). MATERIALS AND METHODS: We analyzed data originally collected in a prospective multicenter study. In the parent study, we identified ED patients referred to CT for evaluation of abdominal pain. We surveyed their physicians before and after CT to identify changes in leading diagnoses, diagnostic confidence, and admission decisions...
January 11, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28073157/comparison-of-parent-peer-psychiatric-and-cannabis-use-influences-across-stages-of-offspring-alcohol-involvement-evidence-from-the-coga-prospective-study
#14
Kathleen K Bucholz, Vivia V McCutcheon, Arpana Agrawal, Danielle M Dick, Victor M Hesselbrock, John R Kramer, Samuel Kuperman, John I Nurnberger, Jessica E Salvatore, Marc A Schuckit, Laura J Bierut, Tatiana M Foroud, Grace Chan, Michie Hesselbrock, Jacquelyn L Meyers, Howard J Edenberg, Bernice Porjesz
BACKGROUND: All stages of development of alcohol use disorder (AUD) have not been equally studied. While initiation of drinking has been given considerable attention, other stages have not been as thoroughly investigated. It is not clear whether the same factors are associated consistently across early and late transitions in AUD involvement. High-risk family samples that are enriched for AUD vulnerability and transitions in AUD development offer an opportunity to examine influences across multiple stages of AUD development...
January 10, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28068614/the-gender-difference-in-depressive-prevalence-is-due-to-high-prevalence-of-somatic-depression-among-women-who-do-not-have-depressed-relatives
#15
Brett Silverstein, Vladeta Ajdacic-Gross, Wulf Rossler, Jules Angst
BACKGROUND: Given that several studies have found the gender difference in depression to be rooted in psychosocial forces and others have shown the difference to be due to a gender difference in somatic depression, we compared the gender difference in somatic depression among respondents who reported no relative depressed with that of all other depressed respondents. METHODS: Respondents in a representative sample from the Zurich study who met criteria for somatic depression and reported no relatives (first-degree, or parents, or mothers, or fathers in separate analyses) with depression were compared to other depressed respondents as to gender...
January 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28062935/pornography-religion-and-parent-child-relationship-quality
#16
Samuel L Perry, Kara J Snawder
Frequent pornography use is often negatively associated with marital quality. Recent research has argued that this negative association is particularly strong for those who are embedded in religious communities, likely due to the greater stigma and shame associated with viewing pornography. In order to test and extend this theory, the current study examined how religious service attendance moderates the link between parents' pornography consumption and four measures of parent-child relationship quality. Analyses of 2006 Portraits of American Life Study data (N = 2610) revealed that greater pornography viewing predicted negative outcomes on two out of four measures of parent-child relationship quality, while religious service attendance was associated with more positive parent-child relationship outcomes...
January 6, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28062346/parental-concordance-regarding-problems-and-hopes-for-seriously-ill-children-a-two-year-cohort-study
#17
Douglas L Hill, Pamela G Nathanson, Rebecca M Fenderson, Karen W Carroll, Chris Feudtner
CONTEXT: Parents of a seriously ill child may have different concerns and hopes for their child and these concerns and hopes may change over time. OBJECTIVE: In a mixed-method prospective cohort of parental dyads of children with serious illness, to describe the major problems and hopes perceived for their child, examine the degree of concordance between parents, and assess whether prevalence and concordance change over time. METHODS: 84 parents (42 dyads) of seriously ill children reported the major problems and hopes for their children at baseline...
January 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28058517/variation-in-response-to-evidence-based-group-preventive-intervention-for-disruptive-behavior-problems-a-view-from-938-coping-power-sessions
#18
John E Lochman, Thomas J Dishion, Caroline L Boxmeyer, Nicole P Powell, Lixin Qu
Prior research suggests that under some conditions, interventions that aggregate high-risk youth may be less effective, or at worse, iatrogenic. However, group formats have considerable practical utility for delivery of preventive interventions, and thus it is crucial to understand child and therapist factors that predict which aggressive children can profit from group intervention and which do not. To address these questions we video-recorded group Coping Power intervention sessions (938 sessions), coded both leader and participant behavior, and analyzed both leader and children's behaviors in the sessions that predicted changes in teacher and parent, reports of problem behavior at 1-year follow up...
January 5, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28057008/correlates-of-preschool-children-s-objectively-measured-physical-activity-and-sedentary-behavior-a-cross-sectional-analysis-of-the-splashy-study
#19
Einat A Schmutz, Claudia S Leeger-Aschmann, Thomas Radtke, Stefanie Muff, Tanja H Kakebeeke, Annina E Zysset, Nadine Messerli-Bürgy, Kerstin Stülb, Amar Arhab, Andrea H Meyer, Simone Munsch, Jardena J Puder, Oskar G Jenni, Susi Kriemler
BACKGROUND: Identifying ways to promote physical activity and decrease sedentary time during childhood is a key public health issue. Research on the putative influences on preschool children's physical activity (PA) and sedentary behavior (SB) is limited and has yielded inconsistent results. Our aim was to identify correlates of PA and SB in preschool children. METHODS: Cross-sectional data were drawn from the Swiss Preschoolers' Health Study (SPLASHY), a Swiss population-based cohort study...
January 5, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28056382/poverty-dynamics-and-parental-mental-health-determinants-of-childhood-mental-health-in-the-uk
#20
Emla Fitzsimons, Alissa Goodman, Elaine Kelly, James P Smith
Using data from the British Millennium Cohort Study (MCS), an ongoing longitudinal study of a cohort of 18,827 children born in the UK in 2000-2001, we investigate important correlates of mental health issues during childhood. MCS respondents were sampled at birth, at age 9 months, and then when they were 3, 5, 7 and 11 years old. Each sweep contains detailed information on the family's SES, parenting activities, developmental indicators, parental relationship status, and indicators of parental mental health...
December 28, 2016: Social Science & Medicine
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