keyword
https://read.qxmd.com/read/38447107/the-incidence-of-postoperative-complications-following-lumbar-and-bone-marrow-punctures-in-pediatric-anesthesia-insights-from-apricot
#21
JOURNAL ARTICLE
Krystelle Dagher, Claudia Benvenuti, Kathy Virag, Walid Habre
OBJECTIVE OF THE STUDY: Bone marrow aspiration and lumbar puncture are procedures frequently performed in pediatric oncology. We aimed at assessing the incidence and risk factors of perioperative complications in children undergoing these procedures under sedation or general anesthesia. METHODS: Based on the APRICOT study, we performed a secondary analysis, including 893 children undergoing bone marrow aspiration and lumbar puncture. The primary outcome was the incidence of perioperative complications...
March 4, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38441169/identifying-a-core-protein-signature-of-small-extracellular-vesicles-derived-from-b-cell-precursor-acute-lymphoblastic-leukaemia
#22
JOURNAL ARTICLE
Nathaniel Edward Bennett Saidu, Miriam Aarsund, Eva Sørensen, Maria Stensland, Tuula Anneli Nyman, Aina Ulvmoen, Yunjie Wu, Marit Inngjerdingen
Acute paediatric leukaemia is diagnosed and monitored via bone marrow aspirate assessment of blasts as a measure of minimal residual disease. Liquid biopsies in the form of blood samples could greatly reduce the need for invasive bone marrow aspirations, but there are currently no blood markers that match the sensitivity of bone marrow diagnostics. Circulating extracellular vesicles (EVs) represent candidate biomarkers that may reflect the blast burden in bone marrow, and several studies have reported on the utility of EVs as biomarkers for adult haematological malignancies...
March 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38435256/bone-marrow-aspirate-concentrate-harvest-techniques-for-the-sports-medicine-surgeon
#23
JOURNAL ARTICLE
Sachin Allahabadi, Harkirat Jawanda, Zeeshan A Khan, Christopher M Brusalis, Jorge Chahla, Brian J Cole, Nikhil N Verma
The use of bone marrow aspirate concentrate (BMAC) as a surgical augment to enhance biologic healing has been gaining popularity in a variety of sports medicine procedures. Due to its reliable availability from multiple sites, including the proximal tibia, proximal humerus, and anterior superior iliac spine, BMAC can be harvested at a location selected to be adjacent to the primary procedure. This Technical Note aims to highlight 3 different harvest sites for BMAC, allowing orthopaedic sports medicine surgeons to localize their harvest site based on the proximity of the planned procedure and ultimately increase efficiency...
February 2024: Arthroscopy Techniques
https://read.qxmd.com/read/38434522/exploring-the-molecular-biomarker-utility-of-circcct3-in-multiple-myeloma-a-favorable-prognostic-indicator-particularly-for-r-iss-ii-patients
#24
JOURNAL ARTICLE
Maria Papatsirou, Christos K Kontos, Ioannis Ntanasis-Stathopoulos, Panagiotis Malandrakis, Diamantis C Sideris, Despina Fotiou, Christine-Ivy Liacos, Maria Gavriatopoulou, Efstathios Kastritis, Meletios A Dimopoulos, Andreas Scorilas, Evangelos Terpos
Circular RNAs (circRNAs) are associated with the pathobiology of multiple myeloma (MM). Recent findings regarding circCCT3 support its involvement in the development and progression of MM, through microRNA sponging. Thus, we aimed to examine the expression of circCCT3 in smoldering and symptomatic MM and to assess its clinical importance. Three cell lines from plasma cell neoplasms were cultured and bone marrow aspirate (BMA) samples were collected from 145 patients with MM or smoldering MM. Next, CD138+ enrichment was performed in BMA samples, followed by total RNA extraction and reverse transcription...
January 2024: HemaSphere
https://read.qxmd.com/read/38433573/comparison-of-optical-genome-mapping-with-conventional-diagnostic-methods-for-structural-variant-detection-in-hematologic-malignancies
#25
JOURNAL ARTICLE
Yeeun Shim, Yu-Kyung Koo, Saeam Shin, Seung-Tae Lee, Kyung-A Lee, Jong Rak Choi
BACKGROUND: Structural variants (SVs) are currently analyzed using a combination of conventional methods; however, this approach has limitations. Optical genome mapping (OGM), an emerging technology for detecting SVs using a single-molecule strategy, has the potential to replace conventional methods. We compared OGM with conventional diagnostic methods for detecting SVs in various hematologic malignancies. METHODS: Residual bone marrow aspirates from 27 patients with hematologic malignancies in whom SVs were observed using conventional methods (chromosomal banding analysis, FISH, an RNA fusion panel, and reverse transcription PCR) were analyzed using OGM...
March 4, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38433500/sensitivity-specificity-and-accuracy-of-molecular-profiling-on-circulating-cell-free-dna-in-refractory-or-relapsed-multiple-myeloma-patients-results-of-mm-ep1-study
#26
JOURNAL ARTICLE
C Quivoron, J-M Michot, A Danu, H Lecourt, V Saada, K Saleh, V Vergé, S Cotteret, O A Bernard, V Ribrag
As a promising alternative to bone marrow aspiration (BMA), mutational profiling on blood-derived circulating cell-free tumor DNA (cfDNA) is a harmless and simple technique to monitor molecular response and treatment resistance of patients with refractory/relapsed multiple myeloma (R/R MM). We evaluated the sensitivity and specificity of cfDNA compared to BMA CD138 positive myeloma plasma cells (PCs) in a series of 45 R/R MM patients using the 29-gene targeted panel (AmpliSeq) NGS. KRAS , NRAS , FAM46C , DIS3 , and TP53 were the most frequently mutated genes...
March 3, 2024: Leukemia & Lymphoma
https://read.qxmd.com/read/38431960/primary-hepatic-neuroblastoma-in-a-5-5-month-old-boy-a-case-report
#27
JOURNAL ARTICLE
Farzad Kompani, Alieh Safari Sharari, Elmira Haji Esmaeil Memar, Mahya Ghahremanloo
The most frequent type of extracranial solid tumor in pediatric cases is neuroblastoma (NB), almost always arising in tissues with sympathetic innervation with only a few reported cases arising in other organs. NBs with hepatic involvement are typically metastatic lesions as primary hepatic NBs are extremely rare. This study presents a 5.5-month-old boy with primary hepatic NB. This case study describes a male 5.5-month-old preterm infant who presented with overt hepatomegaly. Laboratory tests showed an abnormally high level of alpha-fetoprotein...
January 1, 2024: Archives of Iranian Medicine
https://read.qxmd.com/read/38427772/acute-panmylelosis-with-myelofibrosis-a-rare-case-report-with-review-of-literature
#28
JOURNAL ARTICLE
Surbhi Dahiya, Jyoti Kotwal, Sabina Langer, Amrita Saraf, Pallavi Prakhar, Deepika Gupta, Nitin Gupta, Vandana Arya
Acute panmyelosis with myelofibrosis (APMF) corresponds to <1% cases of acute myeloid leukemia, which could be an underestimation due to missed diagnosis. Due to its rapidly fatal course, it warrants a timely and correct diagnosis. We present a case of a 44-year male who came with a short history of fever, generalised weakness, revealed pancytopenia with occasional circulating blast in the peripheral blood smear. Bone marrow aspirate was dry tap,biopsy revealed panmyelosis with myelofibrosis with increased (22%) blasts...
February 19, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38425312/effects-of-high-antibiotic-concentrations-applied-to-continuous-local-antibiotic-perfusion-on-human-bone-tissue-derived-cells
#29
JOURNAL ARTICLE
Yuya Yamamoto, Tomoaki Fukui, Kenichi Sawauchi, Ryo Yoshikawa, Kyohei Takase, Yohei Kumabe, Akihiro Maruo, Takahiro Niikura, Ryosuke Kuroda, Keisuke Oe
AIMS: Continuous local antibiotic perfusion (CLAP) has recently attracted attention as a new drug delivery system for orthopaedic infections. CLAP is a direct continuous infusion of high-concentration gentamicin (1,200 μg/ml) into the bone marrow. As it is a new system, its influence on the bone marrow is unknown. This study aimed to examine the effects of high-concentration antibiotics on human bone tissue-derived cells. METHODS: Cells were isolated from the bone tissue grafts collected from six patients using the Reamer-Irrigator-Aspirator system, and exposed to different gentamicin concentrations...
March 1, 2024: Bone & Joint Research
https://read.qxmd.com/read/38424321/novel-presentation-of-major-histocompatibility-complex-class-ii-deficiency-with-hemophagocytic-lymphohistiocytosis
#30
JOURNAL ARTICLE
Fayhan J Alroqi, Musaab A Alhezam, Abdullah I Almojali, Tlili Barhoumi, Nouf Althubaiti, Yousef Alharbi, Mohammed A Al Balwi, Abdulrahman Alrasheed
PURPOSE: Major histocompatibility complex (MHC) class II deficiency is one of the combined immune deficiency disorders caused by defects in the MHC class II regulatory genes leading to abnormal T cells development and function. Therefore, patients mainly present with increased susceptibility to infections, diarrhea, and failure to thrive. In this report, we present one MHC class II deficient patient with a novel presentation with Hemophagocytic Lymphohistiocytosis (HLH). METHODS: Immunophenotyping of lymphocyte subpopulations and HLA-DR expression was assess by flow cytometry...
March 1, 2024: Journal of Clinical Immunology
https://read.qxmd.com/read/38421887/ex-vivo-efficacy-of-sar442257-anti-cd38-trispecific-t-cell-engager-in-multiple-myeloma-relapsed-after-daratumumab-and-bcma-targeted-therapies
#31
JOURNAL ARTICLE
Alana L Keller, Lauren T Reiman, Olivia Perez de Acha, Sarah E Parzych, Peter A Forsberg, Peter S Kim, Kamlesh Bisht, Hongfang Wang, Helgi Van de Velde, Daniel W Sherbenou
T cell engaging antibodies (TCEs) are showing promising efficacy in relapsed/refractory multiple myeloma (MM), even in patients that relapsed after BCMA targeted therapy. MM patients may have compromised T cell health unaccounted for by preclinical models. Here, we use Myeloma Drug Sensitivity Testing (My-DST) for ex vivo measurement of anti-MM cytotoxicity for the trispecific CD38/CD28xCD3 TCE SAR442257 through activation of the patients' own endogenous T cells to inform clinical development of the compound in MM...
February 29, 2024: Cancer Res Commun
https://read.qxmd.com/read/38418394/paired-single-b-cell-transcriptomics-and-receptor-sequencing-reveal-activation-states-and-clonal-signatures-that-characterize-b-cells-in-acute-myeloid-leukemia
#32
JOURNAL ARTICLE
Shengnan Guo, Gopi S Mohan, Bofei Wang, Tianhao Li, Naval Daver, Yuting Zhao, Patrick K Reville, Dapeng Hao, Hussein A Abbas
BACKGROUND: Acute myeloid leukemia (AML) is associated with a dismal prognosis. Immune checkpoint blockade (ICB) to induce antitumor activity in AML patients has yielded mixed results. Despite the pivotal role of B cells in antitumor immunity, a comprehensive assessment of B lymphocytes within AML's immunological microenvironment along with their interaction with ICB remains rather constrained. METHODS: We performed an extensive analysis that involved paired single-cell RNA and B-cell receptor (BCR) sequencing on 52 bone marrow aspirate samples...
February 28, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38413044/comprehensive-morphologic-characterization-of-bone-marrow-biopsy-findings-in-a-large-cohort-of-patients-with-vexas-syndrome-a-single-institution-longitudinal-study-of-111-bone-marrow-samples-from-52-patients
#33
JOURNAL ARTICLE
Horatiu Olteanu, Mrinal Patnaik, Matthew J Koster, Jennifer L Herrick, Dong Chen, Rong He, David Viswanatha, Kenneth J Warrington, Ronald S Go, Abhishek A Mangaonkar, Taxiarchis Kourelis, Alexander Hines, Sarah E Gibson, Jess F Peterson, Kaaren K Reichard
OBJECTIVES: VEXAS syndrome is an adult-onset autoinflammatory disease caused by a somatic pathogenic mutation in the UBA1 (ubiquitin-like modifier activating enzyme 1) gene. Patients present with rheumatologic manifestations and cytopenias and may have an increased predisposition to myelodysplastic syndrome (MDS) and plasma cell neoplasms. Prior studies have reported on the peripheral blood and bone marrow findings in patients with VEXAS syndrome. Due to the protean clinical presentation and lack of specificity of morphologic features (eg, vacuoles in early erythroid and granulocytic precursors), an optimal screening methodology to identify these patients in a timely fashion is desirable...
February 27, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38406084/blueberry-muffin-syndrome-and-hyperleukocytosis-in-a-newborn-a-diagnostic-challenge
#34
Beatriz Teixeira, Ana Losa, Andreia Meireles, Ana Lachado, Isabel Couto Guerra, Susana Machado, Lídia Branco, Paulo Paulino, Catarina Lau, Natália Oliva-Teles, Carlos Mendes, Tereza Oliva, Liliana Pinho, Luísa Neiva, Elisa Proença
Blueberry muffin syndrome (BMS) in neonates, characterized by widespread nodular lesions, presents diagnostic challenges due to its diverse etiologies. Hyperleukocytosis, with leukocyte counts exceeding 100,000/μL, is a rare phenomenon associated with severe complications in neonates. Congenital leukemia (CL), a rare diagnosis within the first month of life, is linked to high mortality. This case report presents a unique case of BMS with hyperleukocytosis as the initial presentation of CL. A full-term male newborn, born after an uncomplicated pregnancy, except for Kell isoimmunization, with an Apgar score of 9/10, and an irrelevant family history, showed widespread purple nodules consistent with BMS at birth...
January 2024: Curēus
https://read.qxmd.com/read/38395921/primary-thyroid-lymphoma-a-case-series
#35
JOURNAL ARTICLE
Saida Sakhri, Ines Zemni, Mohamed Ali Ayadi, Salma Kamoun, Riadh Chargui, Tarek Ben Dhiab
INTRODUCTION: Primary Thyroid Lymphoma (PTL) is defined as lymphoma involving the thyroid gland alone or the thyroid gland and adjacent neck lymph nodes without contiguous spread or distant metastases at the time of diagnosis. Most thyroid lymphomas are B cell lymphomas, and 98% of all PTL cases are non-Hodgkin's lymphoma. It is a rare disease accounting for around 5% of the thyroid neoplasms and 2% of extranodal lymphomas. If properly diagnosed and treated, the prognosis is favorable...
February 24, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38391335/adult-acute-megakaryoblastic-leukemia-with-persistent-diarrhea-and-extreme-thrombocytosis-a-very-unusual-case
#36
JOURNAL ARTICLE
Nevin Alayvaz Aslan, Gülsün Gülten
Acute megakaryoblastic leukemia (AML-M7) is rarely seen in adult patients and patients usually present with cytopenias. Here we discuss diagnostic challenges and pathologic features in a patient with AML-M7 who presented with thrombocytosis and diarrhea. A 63-year-old male patient presented with persistent diarrhea lasting for 2 months, fatigue, and thrombocytosis. The diagnostic workup included a stool analysis, endoscopy colonoscopy, and imaging studies; however, these studies did not reveal any possible etiology...
April 14, 2023: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38391334/glucose-6-phosphate-dehydrogenase-deficiency-with-coinherited-gaucher-disease-a-rare-association
#37
JOURNAL ARTICLE
Nupur Parakh, Kusha Sharma, Sunita Sharma, Priti Chatterjee, Varinder Singh
Anemia coexisting with Gaucher disease (GD) is often associated with non-hemolytic processes. Few cases of GD with autoimmune hemolytic anemia have been reported. However, literature on GD with concomitant nonimmune hemolytic anemia is scarce. A 1-year 6-month-old male child presented in 2018 with complaints of palpable mass in left upper abdomen, fever, cough, and vomiting. On examination, he had pallor, hepatosplenomegaly of 2 cm and 8 cm below costal margin, respectively. A clinical diagnosis of hemolytic anemia was suspected...
July 6, 2023: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38391303/hemophagocytic-lymphohistiocytosis-following-enteric-fever-a-rare-autopsy-case-report
#38
JOURNAL ARTICLE
Gwendolyn Fernandes, Pooja Mhashete, Pranav Pramod Patwardhan
Hemophagocytic lymphohistiocytosis (HLH) is a severe and frequently underdiagnosed disorder of systemic immune dysregulation resulting in hypercytokinemia and histologically evident hemophagocytosis, We report a case of a 34-year-old man who presented with breathlessness, generalized weakness, and fever of unknown origin with pancytopenia. Clinically the patient was admitted for febrile illness, and treated symptomatically but his general condition worsened leading to death within 21 hours of admission. A complete autopsy was performed...
July 6, 2023: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38390427/solitary-plasmacytoma-of-the-pancreas-a-rare-case-report
#39
Ryan C Rizk, Edmund M Weisberg, Elliot K Fishman
A plasmacytoma is a cancerous growth of abnormal plasma cells that arise within osseous or soft tissue structures. In soft tissue structures, plasmacytomas can present as solitary or multiple masses in the absence of systemic involvement. Solitary plasmacytomas can be subcategorized as extramedullary plasmacytoma (derived from plasma cells located in soft tissues) or osseous plasmacytoma (derived from plasma cells located in the bone marrow). Infrequently, these tumors can arise as extramedullary lesions from the pancreas and present similarly to other tumors, such as pancreatic neuroendocrine tumors (PNETs)...
May 2024: Radiology Case Reports
https://read.qxmd.com/read/38388797/the-impact-of-centrifugal-force-on-isolation-of-bone-marrow-mononuclear-cells-using-density-gradient-centrifugation
#40
JOURNAL ARTICLE
Tianyi Gu, Kongying Li, Xiaoyu Zhang, Ran Xiao, Ningbei Yin, Qian Wang, Li Teng
BACKGROUND: Bone marrow mononuclear cells (BMMNCs) have great potential in bone regenerative therapy. The main method used today to obtain BMMNCs is Ficoll density gradient centrifugation. However, the centrifugal force for this isolation method is still suboptimal. OBJECTIVES: To determine the optimal centrifugal force in Ficoll density gradient centrifugation of bone marrow (BM) to achieve high stem/progenitor cell content BMMNCs for regenerative therapy. METHODS: BM was aspirated from nine minipigs and divided into three groups according to different centrifugal forces (200 g, 300 g and 400 g)...
February 22, 2024: Aesthetic Plastic Surgery
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