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Bone marrow aspirate

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https://www.readbyqxmd.com/read/28101022/necrobiotic-xanthogranuloma-in-a-patient-with-multiple-myeloma
#1
Marlies Wruhs, Robert Feldmann, Isabelle Sawetz, Friedrich Breier, Andreas Steiner
An 82-year-old woman presented with a 9-month history of multiple, well-defined skin lesions on her neck and upper chest, progressively increasing in size. Histological examination of a skin biopsy showed a regular epidermis. In the dermis, granulomatous changes with central necrobiosis were found which extended focally into the subcutaneous fat. The necrobiotic areas were surrounded by Touton cells and foreign-body giant cells. Laboratory analysis revealed leucopenia. Serum electrophoresis and immunofixation disclosed the presence of an IgG-λ paraprotein...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28076752/methotrexate-associated-primary-hepatic-malignant-lymphoma-following-hepatectomy-a-case-report
#2
Daisuke Takei, Tomoyuki Abe, Hironobu Amano, Naomichi Hirano, Tsuyoshi Kobayashi, Hideki Ohdan, Toshinori Kondo, Masahiro Nakahara, Toshio Noriyuki
INTRODUCTION: Recently, immunosuppressant-associated malignant lymphoma (ML) cases have been increasing along with the development of several effective immunosuppressant drugs for rheumatoid arthritis (RA). Among methotrexate (MTX)-associated lymphoproliferative disorders, primary hepatic lymphoma (PHL) in patients with RA following surgical resection has not been reported previously. PRESENTATION OF CASE: A 65-year-old woman who is a hepatitis B virus carrier with a history of RA was admitted...
December 21, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28074480/clonal-reticulohistiocytosis-of-the-skin-and-bone-marrow-associated-with-systemic-mastocytosis-and-acute-myeloid-leukaemia
#3
Nicola Fusco, Arturo Bonometti, Claudia Augello, Sonia Fabris, Leonardo Boiocchi, Stefano Fiori, Denise Morotti, Nicola Fracchiolla, Emilio Berti, Umberto Gianelli
AIMS: The aims of this study were to define whether diffuse cutaneous reticulohistiocytosis could be underpinned by somatic genetic alterations and represent precursor to more aggressive forms of disease. METHODS AND RESULTS: A 59-year-old man with diffuse cutaneous reticulohistiocytosis, experienced bone marrow localisation of the disease, with associated systemic mastocytosis and acute myeloid leukaemia. Cytogenetic analyses of the bone marrow aspirate revealed the presence of a derivative chromosome giving rise to a partial trisomy of chromosome 1q and a partial monosomy of chromosome 9q...
January 11, 2017: Histopathology
https://www.readbyqxmd.com/read/28070163/development-of-reverse-transcription-loop-mediated-isothermal-amplification-for-simple-and-rapid-detection-of-promyelocytic-leukemia-retinoic-acid-receptor-%C3%AE-mrna
#4
Yuki Hashimoto, Yuki Hatayama, Nao Kojima, Shota Morishita, Satoko Matsumoto, Yuzuru Hosoda, Ayako Hara, Toru Motokura
BACKGROUND: Acute promyelocytic leukemia (APL) is a disease characterized by expression of Promyelocytic Leukemia-Retinoic Acid Receptor α (PML-RARα) chimeric mRNA. Although APL is curable, early death due to hemorrhage is a major problem. Here, we report the development of a simple and rapid diagnostic method for APL based on reverse transcription loop-mediated isothermal amplification (RT-LAMP). METHODS: An RT-LAMP primer set was designed to detect three types of PML-RARα mRNA in a single reaction...
December 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/28067962/concurrent-multiple-myeloma-and-mast-cell-neoplasia-in-a-13-year-old-castrated-male-maine-coon-cat
#5
Jonathan M Bagwell, Heather R Herd, Melanie A Breshears, Steven Hodges, Theresa E Rizzi
A 13-year-old, castrated male Maine Coon cat was presented to Oklahoma State University Boren Veterinary Medical Teaching Hospital for yearly echocardiographic examination monitoring hypertrophic cardiomyopathy (HCM) diagnosed in 2003. Physical examination revealed a heart murmur and premature beats, likely related to HCM, but was otherwise unremarkable. A biochemistry profile revealed a hyperglobulinemia (6.3 g/dL). Cytologic examination of fine-needle aspirates from liver and spleen revealed increased numbers of plasma cells and mast cells, confirmed with subsequent histologic examination...
January 9, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28065238/selection-of-biopsy-site-for-patients-with-systematic-amyloidosis
#6
Chun-Lan Zhang, Jun Feng, Xin-Xin Cao, Cong-Li Zhang, Kai-Ni Shen, Xu-Fei Huang, Lu Zhang, Dao-Bin Zhou, Jian Li
Objective To evaluate the sensitivities of various biopsy methods for the diagnosis of systematic amyloidosis (SA). Methods The clinical data and biopsy results of 194 SA patients who were treated in Peking Union Medical College Hospital from January 2009 to June 2015 were retrospectively analyzed. Results The highest sensitivity was achieved by biopsy of affected organs,with renal biopsy 97.4%,heart biopsy 95.0% and liver biopsy 87.5%. Among non-invasive biopsy methods,tongue biopsy was found to be 75% sensitive,followed by gingiva biopsy at 57%,abdominal fat pad aspiration at 57%,rectum biopsy at 16%,and bone marrow examination at 8%...
December 20, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28062659/bone-marrow-biopsies-performed-by-both-the-powered-oncontrol-drill-device-and-the-jamshidi-needle-produce-adequate-specimens
#7
Sarika Jain, Mark Enzerra, Rohtesh S Mehta, Roy Smith, Miroslav Djokic
OBJECTIVE: The aim of our study was to evaluate the adequacy and quality of the bone marrow (BM) obtained by OnControl powered drill (P-group) and to compare it with manual procedure (M-group). DESIGN: Retrospective analysis was done on 75 BM specimens; Jamshidi needle (n=44) and OnControl (n=31). Biopsy length after fixation, evaluable marrow length and total area, and fragmentation, aspiration and marrow dropout artefacts were compared. RESULTS: Biopsies were sufficient for diagnosis in 38/44 cases (86%) in the M-group and in 26/31 cases (83%) in the P-group...
January 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28042161/suspected-immune-mediated-neutropenia-and-corticosteroid-responsive-pancytopenia-in-a-portuguese-water-dog
#8
Ellen B Denstedt
An 8-year-old spayed Portuguese water dog was presented with dysuria, lethargy, and anorexia. A profound neutropenia and pancytopenia were identified. Bone marrow aspirates revealed neutrophilic hyperplasia, a significant left shift, and toxic changes, suggesting immune-mediated destruction as a likely underlying mechanism. Immunosuppressive therapy was instituted and clinical signs improved.
January 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28041941/a-simple-flow-cytometry-method-to-evaluate-peripheral-blood-contamination-of-bone-marrow-aspirates
#9
José Antonio Delgado, Francisco Guillén-Grima, Cristina Moreno, Carlos Panizo, Carmen Pérez-Robles, Juan José Mata, Laura Moreno, Paula Arana, Silvia Chocarro, Juana Merino
Bone marrow (BM) aspirates used for flow-cytometry (FCM) studies are usually obtained from a second aspiration, as the primary aspirate is used for morphological assessment. For this reason, the FCM samples unavoidably contain some blood; although, good-quality samples contain only a small amount. It is of utmost importance to assess the quality of samples prior to FCM analysis; yet, contamination with peripheral blood (PB) is not evaluated in most laboratories, possibly because the methods available are either qualitative or too complex for daily practice...
December 29, 2016: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28040556/tuberculosis-associated-hemophagocytic-lymphohistiocytosis-in-an-umbilical-cord-blood-transplant-recipient
#10
Bing Long, Lei Cheng, Shu-Ping Lai, Jing-Wen Zhang, Yan-Ling Sun, Wen-Xin Lai, Hai-Yan Zhang, Ying Lu, Dong-Jun Lin, Xu-Dong Li
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal condition that can be primary or secondary. Secondary HLH due to Mycobacterium tuberculosis (TB) is uncommon. We report a case of tuberculosis-associated HLH in an umbilical cord blood transplant (UCBT) recipient and discuss its clinical characteristics and challenges. METHODS: Hematologic investigations, bone marrow aspirates, Xpert MTB/RIF test of TB with peripheral blood were performed...
December 28, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28024959/clinicopathologic-immunophenotyping-and-cytogenetic-analysis-of-sweet-syndrome-in-egyptian-patients-with-acute-myeloid-leukemia
#11
Mohamed El-Khalawany, Soha Aboeldahab, Al-Sadat Mosbeh, Aida Thabet
BACKGROUND: Sweet syndrome (SS) is an uncommon dermatologic disorder that could be associated with hematologic malignancies. OBJECTIVE: To describe the clinicopathologic, immunophenotyping and cytogenetic characteristics of SS in Egyptian patients with acute myeloid leukemia (AML). METHODS: The study was conducted during the period from April 2011 to March 2015. For each patient, a clinical evaluation and histological assessment of cutaneous lesions were recorded...
October 26, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28018908/partial-cranial-cruciate-ligament-tears-treated-with-stem-cell-and-platelet-rich-plasma-combination-therapy-in-36-dogs-a-retrospective-study
#12
Sherman O Canapp, Christopher S Leasure, Catherine Cox, Victor Ibrahim, Brittany J Carr
OBJECTIVE: To evaluate outcomes in 36 dogs with a partial cranial cruciate ligament (CCL) tear treated with autologous bone marrow aspirate concentrate (BMAC) or adipose-derived progenitor cells (ADPC) with platelet-rich plasma (PRP) combination. MATERIALS AND METHODS: Medical records of client-owned dogs diagnosed with an early partial (≤50%) tear of the craniomedial band of the CCL that was treated with BMAC-PRP or ADPC-PRP were reviewed from 2010 to 2015. Signalment, medical history, physical and orthopedic examination, objective temporospatial gait analyses, radiographs, day 0 and day 90 diagnostic arthroscopy findings, treatment, and outcome were among the data collected...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28012152/erratum-to-bone-marrow-aspirate-concentrate-for-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-of-outcomes
#13
Jorge Chahla, Mark E Cinque, Jason M Schon, Daniel J Liechti, Lauren M Matheny, Robert F LaPrade, Thomas O Clanton
No abstract text is available yet for this article.
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28011960/visceral-leishmaniasis-in-immunocompromised-diagnostic-and-therapeutic-approach-and-evaluation-of-the-recently-released-idsa-guidelines
#14
Pasquale Pagliano, Tiziana Ascione, Giusy Di Flumeri, Giovanni Boccia, Francesco De Caro
Visceral Leishmaniasis (VL) is a chronic infectious disease endemic in tropical and sub-tropical areas including the Mediterranean basin, caused by a group of protozoan parasites of the genus Leishmania and transmitted by phlebotomine sandflies. Typically, VL is classified as a zoonotic infection when Leishmania infantum is the causative agent and as an anthroponotic one when L. donovani is the causative agent. Immunocompromised patients, in particular HIV positive, are considered at risk of VL. They may present atypical signs and poor response to the treatment due to a compromission of T-helper and regulatory cells activity...
1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28003900/relapse-of-multiple-myeloma-presenting-as-lower-lip-numbness
#15
Yusra M Al-Riyami, Abdulaziz Bakathir, Khalil Al-Farsi, Faisal Al-Azri
Multiple myeloma (MM) is an uncommon malignancy characterised by the proliferation of clonal plasma cells. There are few published reports describing the extramedullary presentation of MM manifesting primarily in the head and neck region. In addition, the occurrence of an isolated relapse of MM in these sites is exceedingly rare. We report a 56-year-old female who presented to the Sultan Qaboos University Hospital, Muscat, Oman, in 2010 with sudden-onset numbness of the lower lip. She had a history of MM in remission following chemotherapy and a bone marrow transplant...
November 2016: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/27994720/repair-potential-of-matrix-induced-bone-marrow-aspirate-concentrate-and-matrix-induced-autologous-chondrocyte-implantation-for-talar-osteochondral-repair-patterns-of-some-catabolic-inflammatory-and-pain-mediators
#16
Giovanna Desando, Isabella Bartolotti, Francesca Vannini, Carola Cavallo, Francesco Castagnini, Roberto Buda, Sandro Giannini, Massimiliano Mosca, Erminia Mariani, Brunella Grigolo
OBJECTIVE: The low regenerative potential of cartilage contributed to the development of different cell therapies aimed to improve the clinical outcome in young patients with Osteochondral Lesions of the Talus (OLT). This study is designed to assess the regenerative potential of autologous matrix-induced Bone Marrow Aspirate Concentrate (mBMAC) and matrix-induced Autologous Chondrocyte Implantation (mACI) evaluating, on a small number of osteochondral biopsies, the expression of some catabolic, inflammatory, and pain mediators...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994719/operative-treatment-for-osteochondral-lesions-of-the-talus-biologics-and-scaffold-based-therapy
#17
REVIEW
Youichi Yasui, Adi Wollstein, Christopher D Murawski, John G Kennedy
OBJECTIVE: Numerous basic science articles have published evidence supporting the use of biologic augmentation in the treatment of osteochondral lesions of the talus (OLT). However, a comprehensive evaluation of the clinical outcomes of those treatment modalities in OLT has yet to be published. The purpose of this review is to provide an evidence-based overview of clinical outcomes following biologic augmentation to surgical treatments for OLT. DESIGN: A comprehensive literature review was performed...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994717/evaluation-and-management-of-osteochondral-lesions-of-the-talus
#18
REVIEW
Christopher A Looze, Jason Capo, Michael K Ryan, John P Begly, Cary Chapman, David Swanson, Brian C Singh, Eric J Strauss
Osteochondral lesions of the talus are common injuries that affect a wide variety of active patients. The majority of these lesions are associated with ankle sprains and fractures though several nontraumatic etiologies have also been recognized. Patients normally present with a history of prior ankle injury and/or instability. In addition to standard ankle radiographs, magnetic resonance imaging and computed tomography are used to characterize the extent of the lesion and involvement of the subchondral bone...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27989346/assessment-of-multipotent-mesenchymal-stromal-cells-in-bone-marrow-aspirate-from-human-calcaneus
#19
Chunmei Li, Cory D Kilpatrick, Shannon S Kenwood, Dean L Glettig, Douglas J Glod, Jason Mallette, Michael R Strunk, Jerry Chang, Siddhesh R Angle, David L Kaplan
Bone marrow aspirates (BMAs), owing to their innate osteogenic potential, are well-documented supplements to osteoconductive and/or osteoinductive materials. The calcaneal body provides foot and ankle surgeons a convenient harvest site with low morbidity and minimal cost. In the present study, we sought to identify and characterize multipotent mesenchymal stromal cells (MSCs) in BMAs harvested from the human calcaneal body. Ten healthy patients aged 18 to 65 years were enrolled in the present study. BMAs were harvested from the patients without any reported postoperative complications related to the harvest...
January 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27984660/recommendations-for-the-standardization-of-bone-marrow-disease-assessment-and-reporting-in-children-with-neuroblastoma-on-behalf-of-the-international-neuroblastoma-response-criteria-bone-marrow-working-group
#20
REVIEW
Susan A Burchill, Klaus Beiske, Hiroyuki Shimada, Peter F Ambros, Robert Seeger, Godelieve A M Tytgat, Penelope R Brock, Michelle Haber, Julie R Park, Frank Berthold
BACKGROUND: The current study was conducted to expedite international standardized reporting of bone marrow disease in children with neuroblastoma and to improve equivalence of care. METHODS: A multidisciplinary International Neuroblastoma Response Criteria Bone Marrow Working Group was convened by the US National Cancer Institute in January 2012 with representation from Europe, North America, and Australia. Practical transferable recommendations to standardize the reporting of bone marrow disease were developed...
December 16, 2016: Cancer
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