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https://www.readbyqxmd.com/read/27893580/the-effects-of-adipose-derived-stem-cell-differentiated-adipocytes-on-skin-burn-wound-healing-in-rats
#1
Yu-Wen Chen, Tabita Timeea Scutaru, Nicolae Ghetu, Eugen Carasevici, Cristian Dumitru Lupascu, Dan Ferariu, Dragos Pieptu, Corneliu-George Coman, Mihai Danciu
Both adipose-derived stem cells (ADSCs) and fat grafting promote burn wound healing, but whether adipogen-derived cells using various inducers such as 3-isobutyl-1-methylxanthine (IBMX) and insulin affect wound healing is unknown. Herein, ADSC-differentiated adipogenic lineages were used in rat burn wounds to evaluate wound healing potential. ADSCs were cultivated using six different adipogenic differentiation conditions (IBMX ± insulin, IBMX for 5 days, high and low Dulbecco's modified Eagle's medium) and in vitro morphological changes and cell proliferations during adipogenic differentiation were recorded...
November 11, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27887867/evaluation-of-function-and-recovery-of-adipose-derived-stem-cells-after-exposure-to-paclitaxel
#2
William M Harris, Ping Zhang, Michael Plastini, Telisha Ortiz, Nikolas Kappy, Jefferson Benites, Edward Alexeev, Shaohua Chang, Ross Brockunier, Jeffrey P Carpenter, Spencer A Brown
BACKGROUND AIMS: Adipose-derived stem cells (ASCs) are considered to play a positive role in wound healing as evidenced by their increasing use in breast reconstructive procedures. After chemotherapy for breast cancer, poor soft tissue wound healing is a major problem. In the present study, the functional capabilities and recovery of ASCs after exposure to chemotherapeutic agent paclitaxel (PTX) using in vitro and ex vivo models were demonstrated. METHODS: Human ASCs were isolated from periumbilical fat tissue and treated with PTX at various concentrations...
November 22, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27883321/body-size-and-outcomes-in-dialysis-and-transplant-patients-does-it-matter
#3
Mehmet Sukru Sever
The terminologies of "body size", "body mass index (BMI)", "body weight", "large BMI" and "obesity" are controversial for defining the effects of "adiposity" or "fat excess" on the outcomes of dialysis and transplant patients. However, probably these terminologies will be continued to be used in the future as well, because of being older and simpler terminologies. In the general population obesity is a powerful risk factor for cardiovascular morbidity and mortality, while, it conferred a survival advantage to dialysis patients...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27761084/role-of-adipose-derived-stem-cells-in-fat-grafting-and-reconstructive-surgery
#4
Shaun S Tan, Zhi Yang Ng, Weiqing Zhan, Warren Rozen
Autologous fat grafting is commonly utilised to reconstruct soft tissue defects caused by ageing, trauma, chronic wounds and cancer resection. The benefits of fat grafting are minimal donor site morbidity and ease of availability through liposuction or lipectomy. Nonetheless, survival and longevity of fat grafts remain poor post-engraftment. Various methods to enhance fat graft survival are currently under investigation and its stem cell constituents are of particular interest. Cell-assisted lipotransfer refers to the addition of adipose-derived stem cell (ASC) rich component of stromal vascular fraction to lipoaspirate, the results of which have proven promising...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27740957/reconstruction-for-skull-base-defect-using-fat-containing-perifascial-areolar-tissue
#5
Woo Young Choi, Ki Wook Sung, Young Seok Kim, Jong Won Hong, Tai Suk Roh, Dae Hyun Lew, Jong Hee Chang, Kyu Sung Lee
Skull base reconstruction is a challenging task. The method depends on the anatomical complexity and size of the defect. We obtained tissue by harvesting fat-containing perifascial areolar tissue (PAT) for reconstruction of limited skull base defects and volume augmentation. We demonstrated the effective option for reconstruction of limited skull base defects and volume augmentation. From October 2013 to November 2015, 5 patients underwent operations using fat-containing PAT to fill the defect in skull base and/or perform volume replacement in the forehead...
October 6, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27739349/costal-cartilage-graft-with-perichondrium-a-possible-anti-adhesive-material
#6
Norio Fukuda, Hirotaka Asato, Kohei Umekawa, Goro Takada, Takeshi Kan, Shoichi Sasaki
BACKGROUND: Adhesion occurs as a part of the wound healing process, but it sometimes compromises patients' daily activities. The authors were looking for materials and methods that could prevent adhesion, and noticed that the costal cartilage has possibility. The anti-adhesive property of the costal cartilage was examined histologically. METHODS: Thirty-five patients with microtia who provided consent for participating in this study were enrolled between April 2008 and March 2015...
October 14, 2016: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/27686484/reinforcing-the-ventral-penile-shaft-with-pedicled-fat-connective-tissues-before-urethroplasty-lowers-the-risk-for-post-urethroplasty-complications-in-hypospadias
#7
Ryo Sueyoshi, Shogo Seo, Takanori Ochi, Hiroshi Murakami, Yuta Yazaki, Masahiro Takeda, Hiroki Nakamura, Geoffrey J Lane, Atsuyuki Yamataka
PURPOSE: CHARGE is our technique for reinforcing the ventral penile shaft with pedicled pericordal/scrotal fat, pedicled perimeatal connective tissue, or a combination of these at the time of initial hypospadias surgery. Such pedicled grafts "charge" poorly developed urethral plates and thin ventral foreskin prior to urethroplasty to improve compromised vascular perfusion that could prevent post-urethroplasty complications (post-UPC). METHODS: We reviewed post-UPC in 179 staged hypospadias repair patients (1997-2015)...
September 16, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27679753/cytokine-rich-adipose-tissue-extract-production-from-water-assisted-lipoaspirate-methodology-for-clinical-use
#8
Jenny Lopez, Outi Huttala, Jertta-Riina Sarkanen, Ilkka Kaartinen, Hannu Kuokkanen, Timo Ylikomi
Proper functioning wound healing strategies are sparse. Adequate vascular formation to the injured area, as well as replacement of the volume loss, is fundamental in soft tissue repair. Tissue engineering strategies have been proposed for the treatment of these injury sites. Novel cell-free substance, human adipose tissue extract (ATE), has been previously shown to induce in vitro angiogenesis and adipogenesis and in vivo soft tissue formation. This study reports the translation of ATE preparation from laboratory to the operating room (OR)...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27600980/antecedent-thermal-injury-worsens-split-thickness-skin-graft-quality-a-clinically-relevant-porcine-model-of-full-thickness-burn-excision-and-grafting
#9
Anders H Carlsson, Lloyd F Rose, John L Fletcher, Jesse C Wu, Kai P Leung, Rodney K Chan
Current standard of care for full-thickness burn is excision followed by autologous split-thickness skin graft placement. Skin grafts are also frequently used to cover surgical wounds not amenable to linear closure. While all grafts have potential to contract, clinical observation suggests that antecedent thermal injury worsens contraction and impairs functional and aesthetic outcomes. This study evaluates the impact of antecedent full-thickness burn on split-thickness skin graft scar outcomes and the potential mediating factors...
September 3, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27574793/adipose-tissue-derived-microvascular-fragments-improve-vascularization-lymphangiogenesis-and-integration-of%C3%A2-dermal-skin-substitutes
#10
Florian S Frueh, Thomas Später, Nicole Lindenblatt, Maurizio Calcagni, Pietro Giovanoli, Claudia Scheuer, Michael D Menger, Matthias W Laschke
Full-thickness skin defects can be covered with dermal skin substitutes in combination with split-thickness skin grafts. However, slow vascularization of the matrices bears the risk of wound infection and extends the length of hospitalization. To overcome these problems, we describe a promising vascularization strategy. Green fluorescent protein(+) adipose tissue-derived microvascular fragments (ad-MVF) were isolated from epididymal fat pads of C57BL/6-Tg(CAG-EGFP)1Osb/J mice. ad-MVF were seeded on collagen-glycosaminoglycan matrices, which were implanted into full-thickness skin defects in the dorsal skinfold chamber of wild-type C57BL/6 mice...
August 26, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27563609/warfare-related-secondary-anterior-cranioplasty
#11
Ali Ebrahimi, Nasrin Nejadsarvari, Hamid Reza Rasouli, Azin Ebrahimi
BACKGROUND: Anterior cranial bone defects secondary to global war cranial defects pose a unique reconstructive challenge. The objective of this study was to evaluate the outcomes of alloplastic reconstructions of cranial bone with titanium mesh and fat graft after warfare-related cranial trauma. PATIENTS AND METHODS: Thirty-five patients at the plastic and reconstructive surgery ward of our hospital underwent anterior cranioplasty with titanium mesh with or without fat grafts from lower abdominal wall...
January 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/27556757/evidence-based-scar-management-how-to-improve-results-with-technique-and-technology
#12
Ibrahim Khansa, Bridget Harrison, Jeffrey E Janis
BACKGROUND: Scars represent the visible sequelae of trauma, injury, burn, or surgery. They may induce distress in the patient because of their aesthetically unpleasant appearance, especially if they are excessively raised, depressed, wide, or erythematous. They may also cause the patient symptoms of pain, tightness, and pruritus. Numerous products are marketed for scar prevention or improvement, but their efficacy is unclear. METHODS: A literature review of high-level studies analyzing methods to prevent or improve hypertrophic scars, keloids, and striae distensae was performed...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27536489/plantar-fat-grafting-and-tendon-balancing-for-the-diabetic-foot-ulcer-in-remission
#13
Cynthia A Luu, Ethan Larson, Timothy M Rankin, Jennifer L Pappalardo, Marvin J Slepian, David G Armstrong
We report on the use of free fat grafting as a means of redistributing normal and shear stress after healing of plantar diabetic foot wounds. Although fat augmentation (lipofilling) has been described previously as an approach to supplement defects and prevent atrophy, including use as an adjunct to wound healing and to mitigate pain in the foot, we are unaware of any reports in the medical literature that have described its use in the high-risk diabetic foot in remission. An active 37-year-old man with type 2 diabetes and neuropathy presented with gangrene of his fifth ray, which was amputated...
July 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27348686/remote-ischemic-preconditioning-recipient-tissues-improves-the-viability-of-murine-fat-transfer
#14
Andrew A Gassman, Michael S Lewis, Justine C Lee
BACKGROUND: Local ischemia before the development of recipient circulation may contribute to the highly variable long-term results of fat grafting. Remote ischemic preconditioning before adipose procurement augments the retention of fat grafts and limits subsequent liposclerosis. However, there is no literature examining what role remote ischemic preconditioning has on the fat graft recipient site. METHODS: Subcutaneous adipose tissue from transgenic mice expressing green fluorescent protein/luciferase was injected into skin folds of wild-type mice...
July 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27338871/clinical-results-of-bronchial-stump-coverage-using-free-pericardial-fat-pad
#15
Katsunari Matsuoka, Naoko Imanishi, Tetsu Yamada, Takahisa Matsuoka, Shinjiro Nagai, Mitsuhiro Ueda, Yoshihiro Miyamoto
OBJECTIVES: Bronchial fistula is a severe complication after thoracic surgery. Although many methods of coverage using various autologous tissues including pedicled pericardial fat pad have been reported to be useful for the prevention of bronchial fistula, the ideal roles of these approaches and the coverage techniques yielding the best results still remain unclear. The clinical use of an autologous free fat graft has been reported in the various surgical fields including otolaryngology, orthopaedics and plastic surgery...
October 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27322024/periumbilical-fat-auto-graft-associated-to-a-porous-orbital-implant-for-socket-reconstruction-after-enucleation
#16
Ramon Medel, Tirso Alonso, Francisco Pelaez, LuzMaria Vasquez
Having to remove the sclera, fat and the optic nerve in patients undergoing an enucleation, translates in a larger volume that needs to be replaced to achieve good motility and aesthetic results. Using a 20 or 22 mm implant can only partially replace the removed volume. We report the results of our enucleation technique, which includes the use of a porous orbital implant combined with a primary fat graft to replace a higher percentage of the removed volume to achieve a better cosmetic outcome and to avoid implant related complications in high risk patients...
August 2016: Orbit
https://www.readbyqxmd.com/read/27246228/the-effect-of-lipoaspirates-on-human-keratinocytes
#17
Bong-Sung Kim, Charel Gaul, Nora E Paul, Manfred Dewor, Jan-Philipp Stromps, Soo Seok Hwang, Mahtab Nourbakhsh, Jürgen Bernhagen, Hans-Oliver Rennekampff, Norbert Pallua
BACKGROUND: One increasingly important trend in plastic, reconstructive, and aesthetic surgery is the use of fat grafts to improve cutaneous wound healing. In clinical practice, lipoaspirates (adipose tissue harvested by liposuction) are re-injected in a procedure called lipofilling. Previous studies, however, mainly evaluated the regenerative effect of isolated adipocytes, adipose-derived stem cells, and excised en bloc adipose tissue on keratinocytes, whereas no study to date has examined the effect of lipoaspirates...
September 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27238730/free-abdominal-fat-transfer-fat-for-partial-and-total-parotidectomy-defect-reconstruction
#18
Myriam Loyo, Christine G Gourin
OBJECTIVES/HYPOTHESIS: A variety of techniques have been proposed for reconstruction of the parotidectomy defect. We reviewed our experience with free abdominal fat transfer (FAT) graft reconstruction of parotidectomy defects for benign and malignant disease. METHODS: The medical records of patients who underwent parotidectomy for benign or malignant disease from 2007 to 2015 were retrospectively reviewed. RESULTS: One hundred and five patients underwent 108 parotidectomies with FAT reconstruction, with bilateral parotidectomy performed in three patients...
May 30, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27071138/a-prospective-postmarket-compassionate-clinical-evaluation-of-a-novel-acellular-fish-skin-graft-which-contains-omega-3-fatty-acids-for-the-closure-of-hard-to-heal-lower-extremity-chronic-ulcers
#19
Chun K Yang, Thais O Polanco, John C Lantis
INTRODUCTION: A novel piscine acellular fish-skin graft product has 510k clearance on the US market. This product (Omega3, Kerecis, Isafjordur, Iceland) is to be used similarly to extracellular matrices (ECMs) on the market (eg, bovine and porcine) except that it contains fats, including omega-3 polyunsaturated fatty acids that have been associated with anti-inflammatory properties in many studies. While many current ECMs are effective on open wounds, studies have largely excluded application to hard-to-heal ulcers...
April 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27062837/-simultaneous-treatment-of-osteoarthritis-of-medial-compartment-with-posterior-cruciate-ligament-injury
#20
Bingli Liu, Xue Wang, Shifeng Dai
OBJECTIVE: To study the results of high tibia osteotomy (HTO) combined with- posterior cruciate ligament (PCL) reconstruction for osteoarthritis (OA) of the medial compartment wit PCL injury. METHODS: Between March 2008 and June 2014, 11 patients with OA of the medial compartment and PCL injury underwent HTO combined with PCL reconstruction. There were 5 males and 6 females, aged 43-55 years (mean, 50.3 years). All patients had a trauma history, and the duration of injury was 3-5 years (mean, 3...
January 2016: Chinese Journal of Reparative and Reconstructive Surgery
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