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Neonatal respiratory distress syndrome

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https://www.readbyqxmd.com/read/27908907/importance-of-diagnostic-work-up-of-guillain-barr%C3%A3-syndrome-in-pregnancy
#1
Elza Pollak-Christian, Kyong-Soon Lee
We report a full-term neonate presenting with symptomatic congenital cytomegalovirus (CMV) infection with hepatosplenomegaly, 'blueberry muffin' rash, intracranial calcifications, thrombocytopenia and respiratory distress. Maternal history was relevant for Guillain-Barré syndrome (GBS) during the first trimester of pregnancy. CMV infection is an important cause of GBS; thus, women presenting GBS during pregnancy should be screened for CMV infection. If positive, they may benefit from specialised monitoring and treatment in the antenatal period, which may decrease the risk of major neurodevelopmental sequelae of congenital CMV in the neonate...
December 1, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27895847/efficacy-of-a-low-cost-bubble-cpap-system-in-treatment-of-respiratory-distress-in-a-neonatal-ward-in-malawi
#2
Kondwani Kawaza, Heather E Machen, Jocelyn Brown, Zondiwe Mwanza, Suzanne Iniguez, Al Gest, E O'Brian Smith, Maria Oden, Rebecca R Richards-Kortum, Elizabeth Molyneux
BACKGROUND: Respiratory failure is a leading cause of neonatal mortality in the developing world. Bubble continuous positive airway pressure (bCPAP) is a safe, effective intervention for infants with respiratory distress and is widely used in developed countries. Because of its high cost, bCPAP is not widely utilized in low-resource settings. We evaluated the performance of a new bCPAP system to treat severe respiratory distress in a low resource setting, comparing it to nasal oxygen therapy, the current standard of care...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27884070/association-of-sp-c-gene-codon-186-polymorphism-rs1124-and-risk-of-rds
#3
Neda Fatahi, Hosein Dalili, Majid Kalani, Nikoo Niknafs, Mamak Shariat, Javad Tavakkoly-Bazzaz, Elaheh Amini, Tahereh Esmaeilnia Shirvani, Amir Kamal Hardani, Roya Taheritafti, Nasrin Ghasemi-Fakhr, Mohsen Ghadami, Fatemeh Nayeri, Ali Rashidi-Nezhad
BACKGROUND: Respiratory distress syndrome (RDS) is a severe pulmonary disease that mainly affects preterm neonates. Surfactant-protein genes' polymorphisms have been mostly evaluated as the candidate contributors in genetics of RDS. However, the results are diverse in different populations. We aimed at investigating the association of rs1124 with RDS development. METHOD: Three hundred and thirty five preterm neonates were enrolled in a multicenter case-control study...
November 24, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27862664/-neonatal-outcomes-in-a-level-ii-regional-neonatal-intensive-care-unit
#4
Raid M R Umran, Asjad Al-Jammali
BACKGROUND: Improving the neonatal mortality is a challenge in developing countries like Iraq. Increasing demands and overload of maternity services can considerably limit the improvement in neonatal outcomes. We aimed to document the numbers, disease patterns and outcomes of admitted newborns and the improvement after implementing clinical protocols and to identify possible future target measures. METHOD: A descriptive study was conducted at neonatal intensive care unit (NICU) at a regional hospital from 2011 to 2013...
November 12, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27859836/outcome-in-monochorionic-twin-pregnancies-with-selective-intrauterine-growth-restriction-according-to-the-umbilical-artery-doppler-pattern-of-the-smaller-twin-a-systematic-review-and-meta-analysis
#5
REVIEW
Danilo Buca, Giorgio Pagani, Giuseppe Rizzo, Alessandra Familiari, Maria Elena Flacco, Lamberto Manzoli, Marco Liberati, Francesco Fanfani, Giovanni Scambia, Francesco D'Antonio
OBJECTIVE: To explore the outcome of monochorionic (MC) twin pregnancies affected by selective intra-uterine growth restriction (sIUGR) according to the umbilical artery Doppler pattern of the smaller twin. METHODS: Medline, Embase, Cinhal and ClinicalTrials.gov databases (2000-2016) were searched. sIUGR was defined as the presence of one twin with estimated fetal weight and/or abdominal circumference less than 10(th) or 5(th) percentile and classified according to the umbilical artery Doppler flow pattern of the smaller twin (type I: persistently positive, type II: persistently absent/reversed, type III: intermittently absent/reversed)...
November 18, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27856214/inflammation-induced-preterm-lung-maturation-lessons-from-animal-experimentation
#6
REVIEW
Timothy J M Moss, Alana J Westover
Intrauterine inflammation, or chorioamnionitis, is a major contributor to preterm birth. Prematurity per se is associated with considerable morbidity and mortality resulting from lung immaturity but exposure to chorioamnionitis reduces the risk of neonatal respiratory distress syndrome (RDS) in preterm infants. Animal experiments have identified that an increase in pulmonary surfactant production by the preterm lungs likely underlies this decreased risk of RDS in infants exposed to chorioamnionitis. Further animal experimentation has shown that infectious or inflammatory agents in amniotic fluid exert their effects on lung development by direct effects within the developing respiratory tract, and probably not by systemic pathways...
October 20, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27854117/treatment-of-neonates-with-respiratory-distress-syndrome-by-proportional-assist-ventilation-plus-synchronized-intermittent-mandatory-ventilation-a-comparison-study
#7
Rong Wu, Zhao F Tian, Xiang Y Kong, Shao D Hua, Jin H Hu, Guo F Zhen
BACKGROUND: The proportion assisted ventilation (PAV) can improve patient-ventilator interaction, reduce the incidence of end-expiratory asynchrony and increase the time of synchrony. PAV could compensate for the leaks by Elastic and resistive unloading and thus is ideal for neonates with uncuffed airways. The aim of this study was to compare the relevant clinical parameters of neonates with respiratory distress syndrome(RDS) who are surported by PAV plus synchronized intermittent mandatory ventilation (SIMV) and SIMV...
November 17, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27853329/high-flow-nasal-cannulae-versus-nasal-continuous-positive-airway-pressure-in-neonates-with-respiratory-distress-syndrome-managed-with-insure-method-a-randomized-clinical-trial
#8
Maliheh Kadivar, Ziba Mosayebi, Nosrat Razi, Shahin Nariman, Razieh Sangsari
BACKGROUND: In recent years, various noninvasive respiratory support (NRS) of ventilation has been provided more in neonates. The aim of this study was to compare the effect of HFNC with NCPAP in post-extubation of preterm infants with RDS after INSURE method (intubation, surfactant, extubation). METHODS: A total of 54 preterm infants with RDS (respiratory distress syndrome) were enrolled in this study. Using a randomized sequence, they were assigned into two groups after INSURE method...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27852668/less-invasive-surfactant-administration-versus-intubation-for-surfactant-delivery-in-preterm-infants-with-respiratory-distress-syndrome-a-systematic-review-and-meta-analysis
#9
Jose C Aldana-Aguirre, Merlin Pinto, Robin M Featherstone, Manoj Kumar
CONTEXT: In spontaneously breathing preterm infants with respiratory distress syndrome (RDS) receiving nasal continuous positive airway pressure, a method of less invasive surfactant administration (LISA) using a thin catheter has been described as an alternative to endotracheal intubation for surfactant delivery to reduce lung injury. OBJECTIVE: A systematic review of randomised controlled trials (RCTs) comparing LISA with the standard method of surfactant delivery for clinical outcomes...
November 15, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27836377/-prevention-of-spontaneous-preterm-birth-excluding-preterm-premature-rupture-of-membranes-guidelines-for-clinical-practice%C3%A2-%C3%A2-text-of-the-guidelines-short-text
#10
L Sentilhes, M-V Sénat, P-Y Ancel, E Azria, G Benoist, J Blanc, G Brabant, F Bretelle, S Brun, M Doret, C Ducroux-Schouwey, A Evrard, G Kayem, E Maisonneuve, L Marcellin, S Marret, N Mottet, S Paysant, D Riethmuller, P Rozenberg, T Schmitz, H Torchin, B Langer
OBJECTIVES: To determine the measures to prevent spontaneous preterm birth (excluding preterm premature rupture of membranes)and its consequences. MATERIALS AND METHODS: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. RESULTS: In France, premature birth concerns 60,000 neonates every year (7.4 %), half of them are delivered after spontaneous onset of labor...
November 8, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27835691/surfactant-protein-a-and-b-gene-polymorphisms-and-risk-of-respiratory-distress-syndrome-in-late-preterm-neonates
#11
Maria-Eleni I Tsitoura, Eleana F Stavrou, Ioannis A Maraziotis, Kosmas Sarafidis, Aglaia Athanassiadou, Gabriel Dimitriou
BACKGROUND AND OBJECTIVES: Newborns delivered late-preterm (between 340/7 and 366/7 weeks of gestation) are at increased risk of respiratory distress syndrome (RDS). Polymorphisms within the surfactant protein (SP) A and B gene have been shown to predispose to RDS in preterm neonates. The aim of this study was to investigate whether specific SP-A and/or SP-B genetic variants are also associated with RDS in infants born late-preterm. METHODS: This prospective cross-sectional study included 56 late-preterm infants with and 60 without RDS...
2016: PloS One
https://www.readbyqxmd.com/read/27834785/physiological-effects-of-a%C3%A2-single-chest-physiotherapy-session-in-mechanically-ventilated-and-extubated-preterm-neonates
#12
Y Mehta, J Shetye, R Nanavati, A Mehta
OBJECTIVE: To assess the changes on various physiological cardio-respiratory parameters with a single chest physiotherapy session in mechanically ventilated and extubated preterm neonates with respiratory distress syndrome. STUDY DESIGN: This is a prospective observational study in neonatal intensive care unit setting. Sixty preterm neonates with respiratory distress syndrome, thirty mechanically ventilated and thirty extubated preterm neonates requiring chest physiotherapy were enrolled in the study...
November 9, 2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/27828734/anti-inflammatory-effects-of-the-new-generation-synthetic-surfactant-chf5633-on-ureaplasma-induced-cytokine-responses-in-human-monocytes
#13
K Glaser, M Fehrholz, B Henrich, H Claus, M Papsdorf, C P Speer
BACKGROUND: Synthetic surfactants represent a promising alternative to animal-derived preparations in the treatment of neonatal respiratory distress syndrome. The synthetic surfactant CHF5633 has proven biophysical effectiveness and, moreover, demonstrated anti-inflammatory effects in LPS-stimulated monocytes. With ureaplasmas being relevant pathogens in preterm lung inflammation, the present study addressed immunomodulatory features on Ureaplasma-induced monocyte cytokine responses. METHODS: Ureaplasma parvum-stimulated monocytes were exposed to CHF5633...
November 9, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27825282/relationship-between-maternal-c-reactive-protein-level-and-neonatal-outcome-in-patients-with-preterm-premature-rupture-of-membranes-treated-with-ampicillin-and-azithromycin
#14
Mehmet Serdar Kutuk, Osman Bastug, Ahmet Ozdemir, Mehmet Adnan Ozturk, Mahmut Tuncay Ozgun, Mustafa Basbug, Tamer Gunes, Selim Kurtoglu
This historical cohort study aimed to assess the relationship between antenatal maternal C-reactive protein (CRP) level and neonatal outcome preterm premature rupture of membranes (PPROM). We reviewed the records of 70 singleton pregnancies with PPROM between 24 and 34 weeks. Maternal CRP levels of neonates with respiratory distress syndrome, neonatal sepsis, grade 3-4 intraventricular haemorrhage and stage 2-3 necrotizing enterocolitis, perinatal mortality were compared with those without these complications...
August 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27817767/-clinical-effects-of-different-ways-of-mechanical-ventilation-combined-with-pulmonary-surfactant-in-treatment-of-acute-lung-injury-acute-respiratory-distress-syndrome-in-neonates-a-comparative-analysis
#15
Ming Chang, Hong-Yan Lu, Hong Xiang, Hou-Ping Lan
OBJECTIVE: To compare the therapeutic effects of high-frequency oscillatory ventilation+pulmonary surfactant (HFOV+PS), conventional mechanical ventilation+pulmonary surfactant (CMV+PS), and conventional mechanical ventilation (CMV) alone for acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in neonates. METHODS: A total of 136 neonates with ALI/ARDS were enrolled, among whom 73 had ALI and 63 had ARDS. They were divided into HFOV+PS group (n=45), CMV+PS group (n=53), and CMV group (n=38)...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27809893/neonatal-mortality-and-morbidity-among-infants-between-24-to-31-complete-weeks-a-multicenter-survey-in-china-from-2013-to-2014
#16
XiangYong Kong, FengDan Xu, Rong Wu, Hui Wu, Rong Ju, XiaoLin Zhao, XiaoMei Tong, HongYan Lv, YanJie Ding, Fang Liu, Ping Xu, WeiPeng Liu, HongBin Cheng, TieQiang Chen, ShuJuan Zeng, WenZheng Jia, ZhanKui Li, HuiXian Qiu, Jin Wang, ZhiChun Feng
BACKGROUND: The outcome of preterm infants has been varied in different hospitals and regions in developing countries. Regular clinical monitor are needed to know the effects of health care. This study aimed to describe the survival and morbidity rates of extreme to very preterm infants in 15 neonatal-intensive care hospitals in China. METHODS: Data were collected from January 1, 2013 to December 31, 2014 for preterm neonates with gestational age (GA) between 24 and 31 complete weeks born in hospitals from our collaborative study group...
November 3, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27799069/effects-of-ultrasound-pregnancy-dating-on-neonatal-morbidity-in-late-preterm-and-early-term-male-infants-a-register-based-cohort-study
#17
Merit Kullinger, Bengt Haglund, Helle Kieler, Alkistis Skalkidou
BACKGROUND: Assessing gestational age by ultrasound can introduce a systematic bias due to sex differences in early growth. METHODS: This cohort study included data on 1,314,602 births recorded in the Swedish Medical Birth Register. We compared rates of prematurity-related adverse outcomes in male infants born early term (gestational week 37-38) or late preterm (gestational week 35-36), in relation to female infants, between a time period when pregnancy dating was based on the last menstrual period (1973-1978), and a time period when ultrasound was used for pregnancy dating (1995-2010), in order to assess the method's influence on outcome by fetal sex...
October 31, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27796747/neonatal-dexamethasone-treatment-exacerbates-hypoxia-ischemia-induced-white-matter-injury
#18
Chia -Yu Yeh, Che-Ming Yeh, Ting-Hsuan Yu, Kan-Hsun Chang, Chiung-Chun Huang, Kuei-Sen Hsu
Dexamethasone, a synthetic glucocorticoid, has been widely used to prevent or ameliorate morbidity of chronic lung disease in preterm infants with respiratory distress syndrome. Despite its beneficial effect on neonatal lung function, growing concern has arisen about adverse effects of this clinical practice on fetal brain development. We demonstrated previously that neonatal dexamethasone (DEX) treatment may render the newborn brain to be more vulnerable to hypoxia/ischemia (HI)-induced gray matter injury...
October 28, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27792696/-smoking-parental-as-risk-factor-for-the-development-of-neonatal-respiratory-distress-syndrome
#19
Mario Alberto Arrieta-Mendoza, Arnoldo Salas-Delgado
: The Respiratory Distress Syndrome (RDS) is one of the most frequent pathologies in the premature neonates and a major cause of morbidity and mortality. The objective of this study was to determine the association between parental smoking and the development of this syndrome. This study was an observational, longitudinal, retrospective, analytical, prolective type, with the neonates in the Neonatal Intensive Care Unit (NICU) of the Hospital Regional Monterrey (HRMI), who developed RDS (cases) and those that do not (controls), during the period January 2012 - April 2015, in both groups were determined the smoking habits of the father and the statistical analysis using SPSS (v...
September 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27790540/a-randomized-trial-comparing-efficacy-of-bubble-and-ventilator-derived-nasal-cpap-in-very-low-birth-weight-neonates-with-respiratory-distress
#20
Sheetal Agarwal, Arti Maria, Mahesh K Roy, Ankit Verma
INTRODUCTION: Continuous Positive Airway Pressure (CPAP) has an established role in the care of Very Low Birth Weight (VLBW) babies with respiratory distress. Bubble CPAP (BCPAP) is a cheap alternative for countries where resources are limited. However, data comparing efficacy of BCPAP with conventional ventilator derived (VCPAP) is limited. AIM: To compare CPAP failure rates between BCPAP and VCPAP among VLBW, with moderate respiratory distress. Secondary objectives were to compare the rates of Intraventricular Haemorrhage (IVH), pulmonary air leaks and deaths between the two groups and determine the predictors of CPAP failure...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
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