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https://www.readbyqxmd.com/read/29924862/identification-of-hepatic-protein-protein-interaction-targets-for-betaine-homocysteine-s-methyltransferase
#1
Francisco Garrido, María Pacheco, Rocío Vargas-Martínez, Roberto Velasco-García, Inmaculada Jorge, Horacio Serrano, Francisco Portillo, Jesús Vázquez, María Ángeles Pajares
Protein-protein interactions are an important mechanism for the regulation of enzyme function allowing metabolite channeling, crosstalk between pathways or the introduction of post-translational modifications. Therefore, a number of high-throughput studies have been carried out to shed light on the protein networks established under different pathophysiological settings. Surprisingly, this type of information is quite limited for enzymes of intermediary metabolism such as betaine homocysteine S-methyltransferase, despite its high hepatic abundancy and its role in homocysteine metabolism...
2018: PloS One
https://www.readbyqxmd.com/read/29924854/food-restriction-promotes-damage-reduction-in-rat-models-of-type-2-diabetes-mellitus
#2
Carlos Vinicius Dalto da Rosa, Jéssica Men de Campos, Anacharis Babeto de Sá Nakanishi, Jurandir Fernando Comar, Isabela Peixoto Martins, Paulo Cézar de Freitas Mathias, Maria Montserrat Diaz Pedrosa, Vilma Aparecida Ferreira de Godoi, Maria Raquel Marçal Natali
There are several animal models of type 2 diabetes mellitus induction but the comparison between models is scarce. Food restriction generates benefits, such as reducing oxidative stress, but there are few studies on its effects on diabetes. The objective of this study is to evaluate the differences in physiological and biochemical parameters between diabetes models and their responses to food restriction. For this, 30 male Wistar rats were distributed in 3 groups (n = 10/group): control (C); diabetes with streptozotocin and cafeteria-style diet (DE); and diabetes with streptozotocin and nicotinamide (DN), all treated for two months (pre-food restriction period)...
2018: PloS One
https://www.readbyqxmd.com/read/29924722/interaction-of-volatile-organic-compounds-and-underlying-liver-disease-a-new-paradigm-for-risk
#3
Anna L Lang, Juliane I Beier
Occupational and environmental exposures to industrial chemicals are known to cause hepatotoxicity and liver injury, in humans and in animal models. Historically, research has focused on severe acute liver injury (e.g., fulminant liver failure) or endstage diseases (e.g., cirrhosis and HCC). However, it has become recently recognized that toxicants can cause more subtle changes to the liver. For example, toxicant-associated steatohepatitis (TASH), characterized by hepatic steatosis, and inflammation, was recently recognized in an occupational cohort exposed to vinyl chloride...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29924717/case-259
#4
Decai Tian, Xiaodong Zhu, Rong Xue, Peng Zhao, Yuanrong Yao
History In November 2012, a previously healthy 31-year-old woman was admitted to our hospital with a 2-month history of right-sided numbness, diplopia, and intermittent nausea and dizziness. She did not have a history of fever, weight loss, headache, photophobia, seizure, or extremity weakness. Physical examination revealed left abduction limitation and right-sided hypoesthesia. Kernig and Brudzinski signs were absent, and pathergy test results were negative. Laboratory evaluation revealed normal complete and differential blood counts, normal serum chemistry, and normal immune function...
July 2018: Radiology
https://www.readbyqxmd.com/read/29924632/heat-shock-protein-72-regulates-hepatic-lipid-accumulation
#5
Ashley E Archer, Robert S Rogers, Alex T Von Schulze, Joshua L Wheatley, E Matthew Morris, Colin S McCoin, John P Thyfault, Paige C Geiger
Induction of the chaperone Heat Shock Protein 72 (HSP72) through heat treatment, exercise, or overexpression improves glucose tolerance and mitochondrial function in skeletal muscle. Less is known about HSP72 function in the liver where lipid accumulation can result in insulin resistance and Nonalcoholic Fatty Liver Disease (NAFLD). The purpose of this study was 1) to determine whether weekly in vivo heat treatment (HT) induces hepatic HSP72 and improves glucose tolerance in rats fed a high-fat diet (HFD) and 2) to determine the ability of HSP72 to protect against lipid accumulation and mitochondrial dysfunction in primary hepatocytes...
June 20, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29924449/high-prevalence-of-a-variety-of-autoantibodies-in-a-population-of-hepatitis-c-virus-infected-individuals
#6
Luz Marina Navarta, Carlos Alberto Espul, Nelson Acosta-Rivero
Hepatitis C virus (HCV) infection has been related to self-reactivity, extrahepatic manifestations and autoimmune diseases. The main goals of this work were to study the prevalence of autoantibodies and their relationship with viral titers and biochemical markers of hepatic damage in patients infected with HCV. Autoantibodies (ANA, AMA, SMA, APC, LKM, DNAds, ANCA, ATG and RF) were determined in 73 individuals with chronic HCV infection and 44 healthy volunteers. The presence of these antibodies was related to demographic variables, viral titers and biochemical parameters...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29924446/significance-of-psmad2-3-and-smad4-in-hepatitis-c-virus-related-liver-fibrosis-and-hepatocellular-carcinoma
#7
Mona Mohammed Moussa, Noha Said Helal, Mohieldin Magdy Youssef
Chronic hepatitis C (CHC) is a major public health problem, especially in Egypt. Risk of hepatocellular carcinoma (HCC) development increases as hepatitis C virus (HCV)-related liver diseases progress. Smads act as substrates for the transforming growth factor-beta (TGF-β) family of receptors. This study aims to assess hepatic expression of pSmad2/3 and Smad4 in CHC with different stages of fibrosis and grades of necro-inflammation as well as in HCC on top of CHC. This study was done on 33 core liver biopsies from patients with CHC (15 with early fibrosis and 18 with late fibrosis), 15 liver specimens from HCC cases on top of CHC, as well as five normal controls...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29924338/insect-retroelements-provide-novel-insights-into-the-origin-of-hepatitis-b-viruses
#8
Zhen Gong, Guan-Zhu Han
The origin of hepadnaviruses (Hepadnaviridae), a group of reverse-transcribing DNA viruses that infect vertebrates, remains mysterious. All the known retrotransposons are only distantly related to hepadnaviruses. Here we report the discovery of two novel lineages of retroelements, which we designate hepadnavirus-like retroelement (HEART1 and HEART2), within the insect genomes through screening 1,095 eukaryotic genomes. Both phylogenetic and similarity analyses suggest that the HEART retroelements represent the closest non-viral relatives of hepadnaviruses so far...
June 19, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29924298/metabolic-signature-of-healthy-lifestyle-and-its-relation-with-risk-of-hepatocellular-carcinoma-in-a-large-european-cohort
#9
Nada Assi, Marc J Gunter, Duncan C Thomas, Michael Leitzmann, Magdalena Stepien, Véronique Chajès, Thierry Philip, Paolo Vineis, Christina Bamia, Marie-Christine Boutron-Ruault, Torkjel M Sandanger, Amaia Molinuevo, Hendriek Boshuizen, Anneli Sundkvist, Tilman Kühn, Ruth Travis, Kim Overvad, Elio Riboli, Augustin Scalbert, Mazda Jenab, Vivian Viallon, Pietro Ferrari
Background: Studies using metabolomic data have identified metabolites from several compound classes that are associated with disease-related lifestyle factors. Objective: In this study, we identified metabolic signatures reflecting lifestyle patterns and related them to the risk of hepatocellular carcinoma (HCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Design: Within a nested case-control study of 147 incident HCC cases and 147 matched controls, partial least squares (PLS) analysis related 7 modified healthy lifestyle index (HLI) variables (diet, BMI, physical activity, lifetime alcohol, smoking, diabetes, and hepatitis) to 132 targeted serum-measured metabolites and a liver function score...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29924273/-barriers-for-the-quality-of-information-in-health-facilities-of-amazon-region
#10
Helen Palma-Pinedo, Mary Reyes-Vega
OBJECTIVES: . To identify the barriers to the quality of information in health facilities in the Amazon region, exploring the case of three health information systems: the epidemiological vigilance, the daily recording of service, and the registry of deaths linked to HIV/AIDS, hepatitis B, and congenital syphilis. MATERIALS AND METHODS: . A quali-quantitative methodology was applied. On the one hand, 57 semi-structured interviews were conducted with administrative and assistance staff at health facilities; on the other hand, a survey was apyplied...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29924209/capsiate-treatment-in-liver-surgeries-may-compromise-its-recovery
#11
Pedro Paulo Barros, Gisele Mara Silva Gonçalves, Gustavo Henrique da Silva, Maria Clara Villaça Dias Bastos, Loren Nogaroto Ramos, Marilia Marinello Fernandes
PURPOSE: To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats. METHODS: The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH...
May 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29924135/exenatide-ameliorates-hepatic-steatosis-and-attenuates-fat-mass-and-fto-gene-expression-through-pi3k-signaling-pathway-in-nonalcoholic-fatty-liver-disease
#12
Shan Li, Xiaoman Wang, Jielei Zhang, Jingyi Li, Xiaogang Liu, Yuanyuan Ma, Chao Han, Lixia Zhang, Lili Zheng
Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. This study was designed to investigate the underlying molecular mechanisms of exenatide therapy on NAFLD. We used in vivo and in vitro techniques to investigate the protective effects of exenatide on fatty liver via fat mass and obesity associated gene (FTO) in a high-fat (HF) diet-induced NAFLD animal model and related cell culture model...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29923995/adalimumab-therapy-in-hepatitis-b-virus-negative-polyarteritis-nodosa-a-case-report
#13
Chrong-Reen Wang, Chao-Chun Yang
INTRODUCTION: Polyarteritis nodosa (PAN) is a difficult-to-treat rheumatology disorder, and biologic agents have been used in such patients with a treatment failure or the disease relapse. CASE PRESENTATION: We report a 42-year-old male Han Chinese who received adalimumab (ADA) alone during his vasculitis relapse, manifesting with weight loss, ankle arthritis, testicular inflammation and new-onset hypertension. Under the ADA 40 mg biweekly subcutaneous injection, there were the disappearance of clinical activity and no disease flares with a follow-up period of 26 months...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923979/median-arcuate-ligament-syndrome-and-arterial-anastomotic-bleeding-inducing-hepatic-artery-thrombosis-after-liver-transplantation-a-case-report
#14
Xiaodong Sun, Zhongqi Fan, Wei Qiu, Yuguo Chen, Chao Jiang, Guoyue Lv
RATIONALE: Median arcuate ligament (MAL) may compress the coeliac trunk inducing median arcuate ligament syndrome (MALS). MALS is a risk factor for hepatic artery thrombosis (HAT) in liver transplant recipients. PATIENT CONCERNS: A thin female complained about upper abdominal pain for two months. DIAGNOSES: The patient was diagnosed as primary biliary cirrhosis. INTERVENTIONS: The patient received two liver transplantations...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923822/investigation-of-the-role-of-gbf1-in-the-replication-of-positive-sense-single-stranded-rna-viruses
#15
Juliette Ferlin, Rayan Farhat, Sandrine Belouzard, Laurence Cocquerel, Antoine Bertin, Didier Hober, Jean Dubuisson, Yves Rouillé
GBF1 has emerged as a host factor required for the replication of positive-sense single-stranded RNA viruses of different families, but its mechanism of action is still unknown. GBF1 is a guanine nucleotide exchange factor for Arf family members. Recently, we identified Arf4 and Arf5 (class II Arfs) as host factors required for the replication of hepatitis C virus (HCV), a GBF1-dependent virus. To assess whether a GBF1/class II Arf pathway is conserved among positive-sense single-stranded RNA viruses, we investigated yellow fever virus (YFV), Sindbis virus (SINV), coxsackievirus B4 (CVB4) and human coronavirus 229E (HCoV-229E)...
June 20, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29923821/evaluation-of-antiviral-efficacy-of-chinese-traditional-medicine-babao-dan-in-rabbits-infected-with-hepatitis-e-virus
#16
Wanyun Gong, Lin Liu, Manyu Li, Lin Wang, Mingyu Zhang, Zhengxin Luo, Siddharth Sridhar, Patrick C Y Woo, Ling Wang
Hepatitis E virus (HEV) is a major cause of acute viral hepatitis. Patients with chronic hepatitis B superinfected with HEV may progress to liver failure. Babao Dan (BD) is a traditional Chinese medicine widely used as an auxiliary option for the treatment of chronic hepatitis and liver cancer in China. This study aimed to evaluate the effect of BD on the management of HEV infection in a rabbit model. Sixty-two specific-pathogen-free (SPF) rabbits were divided randomly into five groups and treated with BD or placebo for 2 weeks...
June 20, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29923793/maternal-folic-acid-supplementation-and-antibody-persistence-5-years-after-hepatitis-b-vaccination-among-infants
#17
Xinyu Zhao, Xinghuo Pang, Fuzhen Wang, Fuqiang Cui, Li Wang, Wei Zhang
BACKGROUND: Maternal exposure to dietary factors during pregnancy may modulate the immunity of offspring by epigenetic programming. But the relationship between intrauterine environment and persistence of protective antibody after hepatitis B vaccination has not been reported. This study was to investigate the 5-year persistence of protective antibody response after primary hepatitis B vaccination, and its relationship with maternal folic acid supplementation. MATERIALS AND METHODS: A total of 1461 children who completed a 3-dose 10 μg recombinant hepatitis B vaccine at birth and did not infect hepatitis B virus were followed up...
June 20, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29923789/hepatitis-a-b-and-a-b-vaccination-series-completion-among-us-adults-a-claims-based-analysis
#18
Parinaz K Ghaswalla, Brandon J Patterson, Wendy Y Cheng, Emilie Duchesneau, Monica Macheca, Mei Sheng Duh
Hepatitis A and B disease burden persists in the US. We assessed hepatitis A and hepatitis B vaccination series completion rates among 350,240 commercial/Medicare and 12,599 Medicaid enrollees aged ≥19 years. A vaccination series was considered as completed provided that the minimum interval between doses, as defined by the CDC, and the minimum number of doses were reached. We stratified completion rates by vaccine type (i.e. monovalent or bivalent) at initial vaccination for each cohort. In the commercial/Medicare cohort, the series completion rate was 32...
June 20, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29923765/physiological-functions-of-ferroportin-in-the-regulation-of-renal-iron-recycling-and-ischemic-acute-kidney-injury
#19
Xueqiao Wang, Xiaoqing Zheng, Juanlian Zhang, Shifeng Zhao, Zhigang Wang, Fudi Wang, Wenjun Shang, Jonathan Barasch, Andong Qiu
Renal iron recycling preserves the filtered iron from urinary excretion. However, it remains debated whether ferroportin (FPN), the solely known iron exporter, is functionally involved in renal iron recycling, and whether renal iron recycling is required for systemic iron homeostasis. We deleted FPN in the whole nephrons using a Nestin-Cre and in the distal nephrons and collecting ducts using a Ksp-Cre, and investigated its impacts on renal iron recycling and systemic iron homeostasis. FPN deletion by Nestin-Cre but not by Ksp-Cre caused excess iron retention and increased ferritin heavy chain (FTH1) specifically in the proximal tubules, and resulted in the reduction of serum and hepatic iron...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29923691/hepatitis-caused-by-herpes-group-viruses-a-review
#20
REVIEW
Arish Noor, Amruta Panwala, Faripour Forouhar, George Y Wu
Herpes virus hepatitis varies in presentation, ranging from asymptomatic to acute liver failure, in both immunocompetent and immunocompromised individuals. Hepatitis caused by herpes viridae family is uncommon and usually results in mild diseases. It is also often self-limited, although in certain populations especially immunosuppressive patients it can cause severe infections, leading to acute to fulminant hepatic failure. In addition, some isolated cases of fulminant disease in immunocompetent individuals have been reported...
June 20, 2018: Journal of Digestive Diseases
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