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Pulmonary hemorrhage

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https://www.readbyqxmd.com/read/29340326/mtorc1-inhibition-is-an-effective-treatment-for-sporadic-renal-angiomyolipoma
#1
Oren Pleniceanu, Dorit Omer, Einat Azaria, Orit Harari-Steinberg, Benjamin Dekel
Introduction: Renal angiomyolipoma (AML) is the most common benign renal tumor. Despite a generally benign histology, AML can result in significant morbidity, from intra-abdominal hemorrhage and reduction in kidney function. While classically associated with the autosomal dominant disorder tuberous sclerosis complex (TSC) or with pulmonary lymphangioleiomyomatosis, most AMLs are sporadic. Mammalian target of rapamycin complex 1 (mTORC1) inhibitors (e.g., sirolimus) have been found to be effective in treating TSC- or lymphangioleiomyomatosis-associated AML, but to date it is unknown whether this strategy is effective for sporadic AML...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29336977/the-role-of-extended-venous-thromboembolism-prophylaxis-following-urologic-pelvic-surgery
#2
Daniel Sagalovich, Rollin Say, Jihad Kaouk, Reza Mehrazin
With the emergence of evidence that venous thromboembolisms (VTE) typically occurs following discharge after urologic pelvic surgery, the focus on extended VTE prophylaxis has intensified. Urologists should have a comprehensive understanding of various VTE risk factors in order to weigh the risk of postoperative hemorrhage with the possibility of fatal pulmonary embolus. Risk factors such as advanced age, obesity, and active malignancy are especially common in patient's undergoing urologic pelvic surgery, and thus this issue becomes particularly relevant to the practicing urologist...
January 11, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29332781/pediatric-extracorporeal-cardiopulmonary-resuscitation-patient-with-traumatic-subarachnoid-hemorrhage-and-takotsubo-syndrome
#3
Thomas E Pearson, Meg A Frizzola, Marc A Priest, Monica A Rochman, Curtis D Froehlich
Takotsubo syndrome is rare in pediatric patients but must be considered in patients with subarachnoid hemorrhage with pulmonary edema and cardiomyopathy. A systematic, collaborative approach is needed to facilitate emergent transfer of patients where extracorporeal cardiopulmonary resuscitation (e-CPR) is used as a lifesaving measure. Extracorporeal membrane oxygenation (ECMO) use in transport requires preplanning, role delineation, resources, and research efforts to be successful. We present an unusual transport case of successful e-CPR/ECMO treatment of Takotsubo syndrome in a 12-year-old boy with an isolated traumatic intracranial injury, cardiomyopathy with pulmonary edema, and multiple cardiac arrests...
January 2018: Air Medical Journal
https://www.readbyqxmd.com/read/29325324/-obstetric-outcome-in-pregnancy-complained-with-pulmonary-hypertension
#4
C X Zhu, W Xiong, J Yang, H Q Chen, G Niu, Z L Wang
Objective: To identify whether pregnancy outcomes vary by the severity of pulmonary hypertension. Methods: A retrospective study was conducted on 78 cases of pregnancies complained with pulmonary hypertension who delivered in the First Affiliated Hospital, Sun Yat-sen University from 2006 to 2016.The selected cases were divided into three groups according to severity of pulmonary hypertension: mild pulmonary hypertension group (mild PAH group) was defined as a mean pulmonary artery pressure 30-49 mmHg, moderate pulmonary hypertension (moderate PAH group) as mean pulmonary artery pressure 50-69 mmHg and severe pulmonary hypertension (severe PAH group) as mean pulmonary artery pressure 70 mmHg or greater...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29320832/-diagnostic-value-of-endobronchial-ultrasonography-with-a-guide-sheath-for-peripheral-pulmonary-ground-glass-opacity
#5
L Zhang, M Li, S He, R Tong, J Q Zhu, G Q Wang
Objective: To explore the diagnostic value of endobronchial ultrasonography with a guide sheath (EBUS-GS) for peripheral pulmonary ground glass opacity (GGO). Methods: The clinical data of 27 consecutive patients with 27 GGOs diagnosed by EBUS-GS between November 2014 to December 2015 in our Cancer Hospital were retrospectively analyzed. The average age of these 27 patients, including 9 males and 18 females, was 59±11 years. The median lesion size of the 27 GGOs was 2.9±1.2 cm, including 24 mixed GGOs and 3 pure GGOs...
November 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29319264/rasmussen-aneurysm
#6
A K Singh, Varun Gupta, Bindu Rani, Manish Kumar, Saurabh Kaushik
Angiographic findings in tuberculosis patients presenting with hemoptysis include hypervascularity, hypertrophy of systemic arteries, aneurysm, systemic to pulmonary anastomosis, and rarely, contrast extravasation. Bronchial arteries are the source of hemorrhage in majority of cases with non-bronchial systemic or pulmonary arteries being less common as the source. Rasmussen's Aneurysm is a very rare sequalae of Pulmonary Tuberculosis. We present one such case of Rasmussen's aneurysm and review of the relevant literature...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29312721/retrospective-review-of-the-diagnosis-and-treatment-of-pulmonary-sequestration-in-28-patients-surgery-or-endovascular-techniques
#7
Shi-Xin Zhang, Hai-Dong Wang, Kang Yang, Wei Cheng, Wei Wu
Background: Pulmonary sequestration (PS) is a rare congenital pulmonary malformation. In this study, we aimed to retrospect and evaluate the diagnosis, treatment, and outcomes of PS in 28 patients at our institute. Methods: The files of 28 patients with PS who were treated with surgery (21 cases) or endovascular intervention (7 cases) between May 2005 and June 2016 from a single institute were retrospectively reviewed. The following data of all patients were analyzed: age, sex, clinical symptoms, diagnostic methods, operative techniques, and treatment outcomes...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29310747/population-based-seroprevalence-of-puumala-hantavirus-in-finland-smoking-as-a-risk-factor
#8
F Latronico, S Mäki, H Rissanen, J Ollgren, O Lyytikäinen, O Vapalahti, J Sane
Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome in humans, that is an endemic disease in Finland. We estimated the seroprevalence of PUUV in Finland and explored risk factors and disease associations by using unique survey data with health register linkage. A total of 2000 sera from a nationwide health survey from 2011, representative of the adult population, were screened for PUUV IgG by immunofluorescence assay. We performed statistical analysis adjusting for stratified cluster design and taking into account sampling weights...
January 9, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29310357/risk-profile-management-and-outcomes-of-patients-with-venous-thromboembolism-attended-in-spanish-emergency-departments-the-espheria-registry
#9
Sonia Jimenez, Pedro Ruiz-Artacho, Marta Merlo, Coral Suero, Albert Antolin, José Ramón Casal, Marta Sanchez, Alejandra Ortega-Duarte, Mar Genis, Pascual Piñera
The objective of this study was to determine the clinical profile of and diagnostic and therapeutic approach to patients with venous thromboembolism (VTE) in Spanish Emergency Departments (EDs). Risk factors, adherence to clinical practice guidelines, and outcomes were also evaluated.Patients with VTE diagnosed in 53 Spanish EDs were prospectively and consecutively included. Demographic data, comorbidities, risk factors for VTE, index event characteristics, hemorrhagic risk, and mortality were evaluated. Adherence to clinical practice guidelines was assessed based on clinical probability scales, requests for determination of D-dimer, use of anticoagulant treatment before confirmation of diagnosis, and assessment of bleeding and prognostic risk...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305977/functional-analysis-of-a-novel-eng-variant-in-a-patient-with-hereditary-hemorrhagic-telangiectasia-hht-identifies-a-new-sp1-binding-site
#10
Sara Plumitallo, Lidia Ruiz-Llorente, Carmen Langa, Jacopo Morini, Gabriele Babini, Donata Cappelletti, Laura Scelsi, Alessandra Greco, Cesare Danesino, Carmelo Bernabeu, Carla Olivieri
Hereditary Hemorrhagic Telangiectasia (HHT) is a rare disease, with an autosomal dominant inheritance and a worldwide incidence of about 1: 5000 individuals. In >80% of patients, HHT is caused by mutations in either ENG or ACVRL1, which code for ENDOGLIN and Activin A Receptor Type II-Like Kinase 1 (ALK1), belonging to the TGF-β/BMP signalling pathway. Typical HHT clinical features are mucocutaneous telangiectases, arteriovenous malformations, spontaneous and recurrent epistaxis, as well as gastrointestinal bleedings...
January 3, 2018: Gene
https://www.readbyqxmd.com/read/29301470/risk-of-complications-of-ultrasound-guided-renal-biopsy-for-adult-and-pediatric-patients-with-systemic-lupus-erythematosus
#11
Y S Sun, I T Sun, H K Wang, A H Yang, C Y Tsai, C J Huang, D F Huang, C C Lai
Objective The objective of this paper is to identify the risk of complications of real-time ultrasound-guided renal biopsy in adult and pediatric patients with systemic lupus erythematosus (SLE). Materials and methods This retrospective study examined outcomes of 296 renal biopsy procedures in 275 SLE patients. Imaging-confirmed symptomatic hematoma was regarded as a major complication when intervention (blood transfusion, angiographic embolization, or surgery) was required or as a minor complication otherwise...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29299105/the-radiologic-and-pathologic-diagnosis-of-biphasic-pulmonary-blastoma
#12
Fadi Nemeh, Anderson H Kuo, Jenny Ross, Carlos S Restrepo
Pulmonary blastomas are rare malignancies, representing 0.25% to 0.5% of all primary lung neoplasms with often aggressive progression and poor prognosis. Clinical management of pulmonary blastomas depends on histologic subtype, staging, and presentation, and may consist of surgery, chemotherapy, and radiation. Biphasic pulmonary blastoma is a subtype of pulmonary blastoma that exhibits biphasic histology, with both epithelial and mesenchymal malignant elements. We report a case of biphasic pulmonary blastoma in a 33-year-old female with 1 pack per day history of smoking for approximately 16 years, who presented with left-sided pleuritic chest pain on deep inspiration without otherwise significant pat medical history...
September 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29296228/ct-guided-hookwire-localization-before-video-assisted-thoracoscopic-surgery-for-solitary-ground-glass-opacity-dominant-pulmonary-nodules-radiologic-pathologic-analysis
#13
Hao-Zhe Huang, Guang-Zhi Wang, Li-Chao Xu, Guo-Dong Li, Ying Wang, Yao-Hui Wang, Xin-Hong He, Wen-Tao Li
The optimal screening or treatment strategies of solitary pulmonary nodules especially ground-glass opacities (GGOs) remain controversial. With CT-guided Hookwire localization, it is accurate to find the small lesions during video-assisted thoracoscopic surgery (VATS). In this study, we evaluate the efficiency and safety of CT-guided Hookwire localization of GGO-dominant (GGO component > 50%) pulmonary nodules before VATS and investigate the correlation between the radiologic features and pathology. From April 2008 to April 2014, a total of 273 patients with solitary GGO-dominant pulmonary nodules were included...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290619/-a-giant-cell-arteritis-revealing-a-goodpasture-s-syndrome
#14
Pascaline M Alix, Amélie Belloi, Émilie Berthoux, Frédérique Dijoud, Emmanuel Villar, Caroline Pariset
Goodpasture's syndrome is a triad of anti-glomerular basement membrane (anti-GBM) circulating antibodies, glomerulonephritis and pulmonary hemorrhage. We reported a 65-year-old woman with headaches, asthenia and weight loss. Giant cell arteritis was confirmed by temporal artery biopsy. The patient had associated renal condition with moderate acute renal failure, proteinuria and haematuria. Renal biopsy showed extracapillary glomerulonephritis and linear staining of immunoglobulins G along glomerular basement membrane...
December 28, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29290576/leukotriene-b4-mediated-neutrophil-recruitment-causes-pulmonary-capillaritis-during-lethal-fungal-sepsis
#15
Esther K S Lee, Mark R Gillrie, Lu Li, Jason W Arnason, Jung Hwan Kim, Liane Babes, Yuefei Lou, Amir Sanati-Nezhad, Stephen K Kyei, Margaret M Kelly, Christopher H Mody, May Ho, Bryan G Yipp
Candida albicans bloodstream infection causes fungal septicaemia and death in over half of afflicted patients. Polymorphonuclear leukocytes (PMN) mediate defense against invasive candidiasis, but their role in protection versus tissue injury and sepsis is unclear. We observe PMN intravascular swarming and subsequent clustering in response to C. albicans yeast in a lethal septic mouse and human pulmonary circulation model. Live C. albicans sequester to the endothelium and are immediately captured by complement-dependent PMN chemotaxis, which is required for host survival...
December 28, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29283976/decreased-tidal-volume-with-increased-height-but-not-colloid-transfusion-is-associated-with-worse-outcomes-and-postoperative-pneumonia-after-coil-embolization-of-aneurysmal-subarachnoid-hemorrhage-a-retrospective-study
#16
Li-Min Zhang, Rui Li, Xiao-Chun Zhao, Ming-Li Wang
BACKGROUND: The tidal volume setting as well as colloid transfusion during the peri-operative period after intracranial aneurysm is controversial. A multicenter retrospective study was conducted to determine whether or not an increased tidal volume setting and colloid transfusion are associated with poor outcomes and postoperative pulmonary complications after intracranial aneurysm. METHOD: Data from endovascular coiling to treat intracranial aneurysms that took place between 30 March 2014 and 30 March 2016 were collected in a multicenter chart...
December 27, 2017: Shock
https://www.readbyqxmd.com/read/29282094/nasal-high-flow-therapy-in-very-low-birth-weight-infants-with-mild-respiratory-distress-syndrome-a-single-center-experience
#17
Antonio Di Mauro, Manuela Capozza, Sergio Cotugno, Silvio Tafuri, Francesco Paolo Bianchi, Federico Schettini, Raffaella Panza, Nicola Laforgia
BACKGROUND: Pulmonary disorders and respiratory failure represent one of the most common morbidities of preterm newborns admitted to neonatal intensive care units (NICUs). The use of nasal high-flow therapy (nHFT) has been more recently introduced into the NICUs as a non-invasive respiratory (NIV) support. METHODS: We performed a retrospective study to evaluate safety and effectiveness of nHFT as primary support for infants born < 29 weeks of gestation and/or VLBW presenting with mild Respiratory Distress Syndrome (RDS)...
December 28, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29279020/short-term-outcomes-comparison-between-preterm-infants-with-and-without-acute-hypoxic-respiratory-failure-attributable-to-presumed-pulmonary-hypoplasia-after-prolonged-preterm-premature-rupture-of-membranes-before-25-gestational-weeks
#18
Ga Young Park, Won Soon Park, Hye Soo Yoo, So Yoon Ahn, Se In Sung, Sung Shin Kim, Yun Sil Chang
OBJECTIVE: To determine the updated outcomes of preterm infants with acute hypoxic respiratory failure attributable to presumed pulmonary hypoplasia (PH) following maternal midtrimester prolonged preterm premature rupture of membranes (PPROM). STUDY DESIGN: Among preterm infants with birthweight < 1500 g and 23-34 weeks gestational age in a single center, infants exposed to maternal prolonged (≥ 7 days) PPROM before 25 gestational weeks (PPPROM25, n = 76) were retrospectively reviewed...
December 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29277898/glucose-6-phosphate-dehydrogenase-inhibition-attenuates-acute-lung-injury-through-reduction-in-nadph-oxidase-derived-reactive-oxygen-species
#19
Ahmed Nadeem, Naif O Al-Harbi, Sheikh F Ahmad, Khalid E Ibrahim, Nahid Siddiqui, Mohammed M Al-Harbi
Acute lung injury (ALI) is a heterogeneous disease with the hallmarks of alveolar capillary membrane injury, increased pulmonary edema and pulmonary inflammation. The commonest direct etiological factor for ALI is usually parenchymal lung infection or hemorrhage. Reactive oxygen species (ROS) generated by NADPH oxidase (NOX2) are thought to play an important role in the pathophysiology of ALI. Glucose-6-phosphate dehydrogenase (G6PD) plays an important role both in production of ROS as well as their removal through supply of NADPH...
December 25, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29276417/bevacizumab-in-the-treatment-of-nsclc-patient-selection-and-perspectives
#20
REVIEW
Alessia E Russo, Domenico Priolo, Giovanna Antonelli, Massimo Libra, James A McCubrey, Francesco Ferraù
Non-small-cell lung cancer (NSCLC) represents about 85% of all lung cancers, and more than half of NSCLCs are diagnosed at an advanced stage. Chemotherapy has reached a plateau in the overall survival curve of about 10 months. Therefore, in last decade novel targeted approaches have been developed to extend survival of these patients, including antiangiogenic treatment. Vascular endothelial growth factor (VEGF) signaling pathway plays a dominant role in stimulating angiogenesis, which is the main process promoting tumor growth and metastasis...
2017: Lung Cancer: Targets and Therapy
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