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Hong, Chang-Ki

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https://www.readbyqxmd.com/read/28210852/treatment-of-rectovaginal-fistula-with-gracilis-muscle-flap-transposition-long-term-follow-up
#1
Seong Oh Park, Ki Yong Hong, Kyo Joo Park, Hak Chang, Jin Yong Shin, Seung-Yong Jeong
PURPOSE: Rectovaginal fistulas are difficult to treat completely, especially when patients present with a history of multiple surgeries and radiation therapy. We aimed to evaluate the efficacy of gracilis muscle flap transposition to treat rectovaginal fistula. METHODS: We performed a retrospective chart review of all gracilis muscle transposition cases and other procedures between January 2009 and July 2016. RESULTS: Total 53 cases were reviewed...
February 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28208711/antidepressant-effects-of-aripiprazole-augmentation-for-cilostazol-treated-mice-exposed-to-chronic-mild-stress-after-ischemic-stroke
#2
Yu Ri Kim, Ha Neui Kim, Ki Whan Hong, Hwa Kyoung Shin, Byung Tae Choi
The aim of this study was to determine the effects and underlying mechanism of aripiprazole (APZ) augmentation for cilostazol (CLS)-treated post-ischemic stroke mice that were exposed to chronic mild stress (CMS). Compared to treatment with either APZ or CLS alone, the combined treatment resulted in a greater reduction in depressive behaviors, including anhedonia, despair-like behaviors, and memory impairments. This treatment also significantly reduced atrophic changes in the striatum, cortex, and midbrain of CMS-treated ischemic mice, and inhibited neuronal cell apoptosis, particularly in the striatum and the dentate gyrus of the hippocampus...
February 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28185769/intact-wound-repair-activity-of-human-mesenchymal-stem-cells-after-ym155-mediated-selective-ablation-of-undifferentiated-human-embryonic-stem-cells
#3
Keun-Tae Kim, Ho-Chang Jeong, C-Yoon Kim, Eun-Young Kim, Si-Hyun Heo, Seung-Ju Cho, Ki-Sung Hong, Hyuk-Jin Cha
BACKGROUND: Risk of teratoma formation during human pluripotent stem cell (hPSC)-based cell therapy is one of the technical hurdles that must be resolved before their wider clinical application. To this end, selective ablation of undifferentiated hPSCs has been achieved using small molecules whose application should be safe for differentiated cells derived from the hPSCs. OBJECTIVE: However, the functional safety of such small molecules in the cells differentiated from hPSCs has not yet been extensively validated...
January 31, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28183163/comparison-of-the-clinical-outcomes-of-patients-with-squamous-cell-carcinoma-of-the-tonsil-receiving-postoperative-ipsilateral-versus-bilateral-neck-radiotherapy-a-propensity-score-matching-analysis-krog-11-07
#4
Youngkyong Kim, Kwan Ho Cho, Sung Ho Moon, Chang Geol Lee, Ki Chang Keum, Sang-Wook Lee, Yong Chan Ahn, Dongryul Oh, Yeon-Sil Kim, Yong Kyun Won, Hong-Gyun Wu, J Hun Hah, Young-Taek Oh
Purpose: The impact of postoperative ipsilateral versus bilateral neck radiotherapy on the clinical outcomes of patients with tonsillar squamous cell carcinoma was analyzed retrospectively. Materials and Methods: Between October 2001 and June 2012, 241 patients with T1-2 and N0-N2b tonsillar carcinoma from 16 institutes underwent postoperative ipsilateral neck radiotherapy (INRT; n=84) or bilateral neck radiotherapy (BNRT; n=157) following a tonsillectomy. Seventy patients were identified from each group by propensity score matching and compared in terms of the overall, disease-free, locoregional relapse-free, and distant metastasis-free survival (OS, DFS, LRRFS, and DMFS, respectively) rates calculated using the Kaplan-Meier method with a log-rank test...
February 9, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28174192/infarcted-myocardium-primed-dendritic-cells-improve-remodeling-and-cardiac-function-after-myocardial-infarction-by-modulating-the-treg-and-macrophage-polarization
#5
Eun Ho Choo, Jun-Ho Lee, Eun-Hye Park, Hyo Eun Park, Nam-Chul Jung, Tae-Hoon Kim, Yoon-Seok Koh, Eunmin Kim, Ki-Bae Seung, Cheongsoo Park, Kwan-Soo Hong, Kwonyoon Kang, Jie-Young Song, Han Geuk Seo, Dae-Seog Lim, Kiyuk Chang
BACKGROUND: -Inflammatory responses play a critical role in left ventricular (LV) remodeling after a myocardial infarction (MI). Tolerogenic dendritic cells (tDCs) can modulate immune responses inducing regulatory T cells (Tregs) in a number of inflammatory diseases. METHODS: -We generated tDCs by treating bone marrow-derived dendritic cells with TNF-α and cardiac lysate from MI mice. We injected MI mice, which were induced by a ligation of the left anterior descending coronary artery in C57BL/6 mice, twice with tDCs within 24 hours and at 7 days after the ligation...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28167883/enhancement-of-seed-dehiscence-by-seed-treatment-with-talaromyces-flavus-gg01-and-gg04-in-ginseng-panax-ginseng
#6
Min-Jeong Kim, Chang-Ki Shim, Yong-Ki Kim, Sung-Jun Hong, Jong-Ho Park, Eun-Jung Han, Seok-Cheol Kim
Seed dehiscence of ginseng (Panax ginseng C. A. Mayer) is affected by moisture, temperature, storage conditions and microbes. Several microbes were isolated from completely dehisced seed coat of ginseng cultivars, Chunpoong and Younpoong at Gumsan, Korea. We investigated the potential of five Talaromyces flavus isolates from the dehiscence of ginseng seed in four traditional stratification facilities. The isolates showed antagonistic activities against fungal plant pathogens, such as Cylindrocarpon destructans, Fusarium oxysporum, Rhizoctonia solani, Sclerotinia nivalis, Botrytis cinerea, and Phytophthora capsici...
February 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28157103/mortality-risk-after-diagnosis-of-early-onset-alzheimer-s-disease-versus-late-onset-alzheimer-s-disease-a-propensity-score-matching-analysis
#7
Ki Jung Chang, Chang Hyung Hong, Kang Soo Lee, Dae Ryong Kang, Jeong Dong Lee, Seong Hye Choi, Seong Yoon Kim, Duk L Na, Sang Won Seo, Do-Kwan Kim, Yunhwan Lee, Young Ki Chung, Ki Young Lim, Jai Sung Noh, Jungsik Park, Sang Joon Son
BACKGROUND/OBJECTIVE: We aimed to compare the risk of mortality in patients with early-onset Alzheimer's disease (EOAD) versus those with late-onset AD (LOAD) using a large number of study subjects. We applied propensity score matching (PSM) to minimize confounding biases in the comparison between EOAD and LOAD. METHODS: We obtained data from elderly Korean subjects with AD (n = 3,611) at baseline from the CREDOS cohort study, which was conducted from November 2005 to July 2013...
February 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28154589/optimal-timing-of-percutaneous-coronary-intervention-for-nonculprit-vessel-in-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-disease
#8
Inna Kim, Min Chul Kim, Hae Chang Jeong, Keun Ho Park, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Ki-Bae Seung, Kiyuk Chang, Youngkeun Ahn
BACKGROUND AND OBJECTIVES: In patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD), the optimal timing of staged percutaneous coronary intervention (PCI) remains unclear. SUBJECTS AND METHODS: This study was a retrospective analysis of 753 STEMI patients with MVD who were treated by multivessel PCI in the Convergent Registry of Catholic and Chonnam University for Acute myocardial infarction (MI). Patients were divided into 3 groups according to the time from initial to staged PCI: group 1 (n=316, multivessel PCI performed during the index procedure), group 2 (n=360, staged PCI within 1 week), and group 3 (n=77, staged PCI after 1 week)...
January 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28122404/clinico-pathological-correlation-of-hepatic-angiomyolipoma-a-series-of-23-resection-cases
#9
Dong Hwan Jung, Shin Hwang, Seung Mo Hong, Ki Hun Kim, Chul Soo Ahn, Deok Bog Moon, Abdulwahab A Alshahrani, Sung Gyu Lee
BACKGROUND: Angiomyolipomas are rare neoplasms of mesenchymal origin and are derived from perivascular epithelioid cells. They usually develop in the kidney and rarely in the liver. Due to their rarity, most hepatic angiomyolipomas have been misinterpreted as hepatocellular carcinoma (HCC) or other hypervascular liver tumours on imaging studies. We aimed to assess the clinico-pathological correlation of hepatic angiomyolipoma. METHODS: We identified 23 patients with hepatic angiomyolipoma through an institutional database search...
January 25, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28117501/microscopic-evidence-for-strong-interaction-between-pd-and-graphene-oxide-that-results-in-metal-decoration-induced-reduction-of-graphene-oxide
#10
Jong-Myeong Jeon, Taemin Ludvic Kim, Young-Seok Shim, You Rim Choi, Seokhoon Choi, Seonyong Lee, Ki Chang Kwon, Seong-Hyeon Hong, Young-Woon Kim, Soo Young Kim, Miyoung Kim, Ho Won Jang
Graphene oxide (GO) is reduced spontaneously when palladium nanoparticles are decorated on the surface. The oxygen functional groups at the GO surface near the nanoparticles are absorbed to the palladium to produce palladium oxide interlayer. Palladium therefore grows on GO with preferred orientations, resulting in unique microstructural and electrical properties.
January 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28117437/ccl2-deficient-mesenchymal-stem-cells-fail-to-establish-long-lasting-contact-with-t-cells-and-no-longer-ameliorate-lupus-symptoms
#11
Hong Kyung Lee, Hyung Sook Kim, Ji Sung Kim, Yong Guk Kim, Ki Hwan Park, Jae Hee Lee, Ki Hun Kim, In Young Chang, Sang-Cheol Bae, Youngsoo Kim, Jin Tae Hong, John H Kehrl, Sang-Bae Han
Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characterized by autoantibody production. Mesenchymal stem cells (MSCs) ameliorate SLE symptoms by targeting T cells, whereas the mechanisms of their efficacy remain incompletely understood. In this study, we show that transfer of human MSCs increased MRL.Fas(lpr) mouse survival, decreased T cell infiltration in the kidneys, and reduced T cell cytokine expression. In vitro, allogeneic mouse MSCs inhibited MRL.Fas(lpr) T cell proliferation and cytokine production...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28112924/discovery-of-pyrrolidine-containing-gpr40-agonists-stereochemistry-effects-a-change-in-binding-mode
#12
Elizabeth Anne Jurica, Ximao Wu, Kristin N Williams, Andres S Hernandez, David S Nirschl, Richard A Rampulla, Arvind Mathur, Min Zhou, Gary Cao, Chunshan Xie, Biji Jacob, Hong Cai, Tao Wang, Brian J Murphy, Heng Liu, Carrie Xu, Lori K Kunselman, Michael B Hicks, Qin Sun, Dora M Schnur, Doree Fay Sitkoff, Elizabeth A Dierks, Atsu Apedo, Douglas B Moore, Kimberly A Foster, Mary Ellen Cvijic, Reshma Panemangalore, Neil A Flynn, Brad D Maxwell, Yang Hong, Yuan Tian, Jason J Wilkes, Bradley A Zinker, Jean M Whaley, Joel C Barrish, Jeffrey A Robl, William R Ewing, Bruce Alan Ellsworth
A novel series of pyrrolidine-containing GPR40 agonists is described as a potential treatment for type 2 diabetes. The initial pyrrolidine hit was modified by moving the position of the carboxylic acid, a key pharmacophore for GPR40. Addition of a 4-cis-CF3 to the pyrrolidine improves the human GPR40 binding Ki and agonist efficacy. After further optimization, the discovery of a minor enantiomeric impurity with agonist activity led to the finding that enantiomers (R,R)-68 and (S,S)-68 have differential effects on the radioligand used for the binding assay, with (R,R)-68 potentiating the radioligand and (S,S)-68 displacing the radioligand...
January 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28110760/prostatic-arterial-embolization-for-control-of-hematuria-in-patients-with-advanced-prostate-cancer
#13
Jhih-Wei Chen, Ji Hoon Shin, Teng-Fu Tsao, Heung-Gyu Ko, Hyun-Ki Yoon, Ki-Chang Han, Somrach Thamtorawat, Bumsik Hong
Nine patients with advanced prostate cancer (stage T4) underwent prostatic arterial embolization (PAE) for refractory prostatic hematuria. Angiograms showed prostatic neovascularity in all cases, and complete PAE was achieved in 8 cases (89% technical success rate). Gross hematuria ceased after PAE in 6 cases, translating to a 67% clinical success rate. There were no PAE-related complications. At 3-month follow-up, 2 cases showed recurrent hematuria, 4 patients had died from PAE-unrelated etiologies, and only 3 patients survived and were without gross hematuria...
February 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28096723/myocardial-t1-and-t2-mapping-techniques-and-clinical-applications
#14
REVIEW
Pan Ki Kim, Yoo Jin Hong, Dong Jin Im, Young Joo Suh, Chul Hwan Park, Jin Young Kim, Suyon Chang, Hye-Jeong Lee, Jin Hur, Young Jin Kim, Byoung Wook Choi
Cardiac magnetic resonance (CMR) imaging is widely used in various medical fields related to cardiovascular diseases. Rapid technological innovations in magnetic resonance imaging in recent times have resulted in the development of new techniques for CMR imaging. T1 and T2 image mapping sequences enable the direct quantification of T1, T2, and extracellular volume fraction (ECV) values of the myocardium, leading to the progressive integration of these sequences into routine CMR settings. Currently, T1, T2, and ECV values are being recognized as not only robust biomarkers for diagnosis of cardiomyopathies, but also predictive factors for treatment monitoring and prognosis...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28066143/acepromazine-inhibits-herg-potassium-ion-channels-expressed-in-human-embryonic-kidney-293-cells
#15
Young Shin Joo, Hong Joon Lee, Jin-Sung Choi, Ki-Wug Sung
The effects of acepromazine on human ether-à-go-go-related gene (hERG) potassium channels were investigated using whole-cell voltage-clamp technique in human embryonic kidney (HEK293) cells transfected with hERG. The hERG currents were recorded with or without acepromazine, and the steady-state and peak tail currents were analyzed for the evaluating the drug effects. Acepromazine inhibited the hERG currents in a concentration-dependent manner with an IC50 value of 1.5 µM and Hill coefficient of 1.1. Acepromazine blocked hERG currents in a voltage-dependent manner between -40 and +10 mV...
January 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28057081/the-efficacy-and-safety-of-co-administration-of-fimasartan-and-rosuvastatin-to-patients-with-hypertension-and-dyslipidemia
#16
Moo-Yong Rhee, Taehoon Ahn, Kiyuk Chang, Shung Chull Chae, Tae-Hyun Yang, Wan Joo Shim, Tae Soo Kang, Jae-Kean Ryu, Deuk-Young Nah, Tae-Ho Park, In-Ho Chae, Seung Woo Park, Hae-Young Lee, Seung-Jea Tahk, Young Won Yoon, Chi Young Shim, Dong-Gu Shin, Hong Seog Seo, Sung Yun Lee, Doo Il Kim, Jun Kwan, Seung-Jae Joo, Myung Ho Jeong, Jin-Ok Jeong, Ki Chul Sung, Seok Yeon Kim, Sang-Hyun Kim, Kook-Jin Chun, Dong Joo Oh
BACKGROUND: Hypertension and dyslipidemia are major risk factors of cardiovascular disease (CVD) events. The objective of this study was to evaluate the efficacy and safety of the co-administration of fimasartan and rosuvastatin in patients with hypertension and hypercholesterolemia. METHODS: We conducted a randomized double-blind and parallel-group trial. Patients who met eligible criteria after 4 weeks of therapeutic life change were randomly assigned to the following groups...
January 5, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28043099/guidelines-for-the-surgical-management-of-laryngeal-cancer-korean-society-of-thyroid-head-and-neck-surgery
#17
Soon-Hyun Ahn, Hyun Jun Hong, Soon Young Kwon, Kee Hwan Kwon, Jong-Lyel Roh, Junsun Ryu, Jun Hee Park, Seung-Kuk Baek, Guk Haeng Lee, Sei Young Lee, Jin Choon Lee, Man Ki Chung, Young Hoon Joo, Yong Bae Ji, Jeong Hun Hah, Minsu Kwon, Young Min Park, Chang Myeon Song, Sung-Chan Shin, Chang Hwan Ryu, Doh Young Lee, Young Chan Lee, Jae Won Chang, Ha Min Jeong, Jae-Keun Cho, Wonjae Cha, Byung Joon Chun, Ik Joon Choi, Hyo Geun Choi, Kang Dae Lee
Korean Society of Thyroid-Head and Neck Surgery appointed a Task Force to develop clinical practice guidelines for the surgical treatment of laryngeal cancer. This Task Force conducted a systematic search of the EMBASE, MEDLINE, Cochrane Library, and KoreaMed databases to identify relevant articles, using search terms selected according to the key questions. Evidence-based recommendations were then created on the basis of these articles. An external expert review and Delphi questionnaire were applied to reach consensus regarding the recommendations...
March 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28012648/impact-of-vasomotion-type-on-prognosis-of-coronary-artery-spasm-induced-by-acetylcholine-provocation-test-of-left-coronary-artery
#18
Eun Mi Lee, Man Ho Choi, Hong Seog Seo, Hyun Ki Kim, Nam-Ho Kim, Cheol Ung Choi, Jin Won Kim, Hong Euy Lim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Dong Joo Oh
BACKGROUND AND AIMS: The impact of vasomotion types on long-term clinical outcomes in patients with coronary artery spasm (CAS) induced by the acetylcholine provocation test (ACH-test) remains unclear. METHODS: We evaluated 4644 consecutive patients with typical resting chest pain (CP), but no angiographically significant coronary artery lesion (<50% stenosis), who underwent an ACH-test. According to their vasomotor response, patients were categorized into four types: normal vasomotion (no CP, no ischemic electrocardiographic changes, and no vasoconstriction), microvascular spasm (CP with <75% vasoconstriction but with CP relief after nitroglycerin infusion), epicardial spasm (CP with ≥75% vasoconstriction), and ACH-test inconclusive (vasoconstriction and/or electrocardiographic changes, but no CP)...
September 16, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28011608/mycobacterial-characteristics-and-treatment-outcomes-in-mycobacterium-abscessus-lung-disease
#19
Won-Jung Koh, Byeong-Ho Jeong, Su-Young Kim, Kyeongman Jeon, Kyoung Un Park, Byung Woo Jhun, Hyun Lee, Hye Yun Park, Dae Hun Kim, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Seung-Heon Lee, Chang Ki Kim, Sung Jae Shin, Charles L Daley, Hojoong Kim, O Jung Kwon
BACKGROUND: Treatment outcomes of patients with Mycobacterium abscessus subspecies abscessus lung disease are poor, and the microbial characteristics associated with treatment outcomes have not been studied systematically. The purpose of this study was to identify associations between microbial characteristics and treatment outcomes in patients with M. abscessus lung disease. METHODS: Sixty-seven consecutive patients with M. abscessus lung disease undergoing antibiotic treatment for ≥12 months between January 2002 and December 2012 were included...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28010876/central-ghrelin-resistance-permits-the-overconsolidation-of-fear-memory
#20
Elia S Harmatz, Lauren Stone, Seh Hong Lim, Graham Lee, Anna McGrath, Barbara Gisabella, Xiaoyu Peng, Eliza Kosoy, Junmei Yao, Elizabeth Liu, Nuno J Machado, Veronica S Weiner, Warren Slocum, Rodrigo A Cunha, Ki A Goosens
BACKGROUND: There are many contradictory findings about the role of the hormone ghrelin in aversive processing, with studies suggesting that ghrelin signaling can both inhibit and enhance aversion. Here, we characterize and reconcile the paradoxical role of ghrelin in the acquisition of fearful memories. METHODS: We used enzyme-linked immunosorbent assay to measure endogenous acyl-ghrelin and corticosterone at time points surrounding auditory fear learning. We used pharmacological (systemic and intra-amygdala) manipulations of ghrelin signaling and examined several aversive and appetitive behaviors...
November 29, 2016: Biological Psychiatry
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