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Hong, Chang-Ki

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https://www.readbyqxmd.com/read/28339070/125i%C3%A2-seed-irradiation-induces-apoptosis-and-inhibits-angiogenesis-by-decreasing-hif-1%C3%AE-and-vegf-expression-in-lung-carcinoma-xenografts
#1
Gui-Ling Xiang, Xin-Hong Zhu, Cun-Zhi Lin, Li-Jun Wang, Yong Sun, Yi-Wei Cao, Fang-Fang Wang
The purpose of this study was to examine the effects of irradiation by 125I seeds in human lung cancer xenograft model and to determine the underlying mechanisms involved, with a focus on angiogenesis. A group of 40 mice bearing A549 lung adenocarcinoma xenografts was randomly separated into 4 groups: control group (n=10), sham seed (0 mCi) implant group (n=10), 125I seed (0.6 mCi) implant group (n=10) and 125I seed (0.8 mCi) implant group (n=10), respectively. The body weight and tumor volume, were recorded every four days until the end of the study...
March 23, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28330757/does-new-instrumentation-improve-radiologic-alignment-of-the-oxford%C3%A2-medial-unicompartmental-knee-arthroplasty
#2
Ki-Mo Jang, Hong Chul Lim, Seung-Beom Han, Chandong Jeong, Seul-Gi Kim, Ji-Hoon Bae
BACKGROUND: A new instrument system has been introduced to improve the accuracy and reproducibility of implant positioning in Oxford® unicompartmental knee arthroplasty (UKA). This study aimed to determine if the new instrumentation could improve postoperative implant positioning and limb alignment, and reduce the occurrence of outliers in Oxford® UKA. METHODS: A total of 77 cases of Oxford® UKA with the new instrumentation were included. Individual matching for the conventional instrument group was performed according to age, sex, and body mass index...
March 19, 2017: Knee
https://www.readbyqxmd.com/read/28323832/age-related-cognitive-decline-and-associations-with-sex-education-and-apolipoprotein-e-genotype-across-ethnocultural-groups-and-geographic-regions-a-collaborative-cohort-study
#3
Darren M Lipnicki, John D Crawford, Rajib Dutta, Anbupalam Thalamuthu, Nicole A Kochan, Gavin Andrews, M Fernanda Lima-Costa, Erico Castro-Costa, Carol Brayne, Fiona E Matthews, Blossom C M Stephan, Richard B Lipton, Mindy J Katz, Karen Ritchie, Jacqueline Scali, Marie-Laure Ancelin, Nikolaos Scarmeas, Mary Yannakoulia, Efthimios Dardiotis, Linda C W Lam, Candy H Y Wong, Ada W T Fung, Antonio Guaita, Roberta Vaccaro, Annalisa Davin, Ki Woong Kim, Ji Won Han, Tae Hui Kim, Kaarin J Anstey, Nicolas Cherbuin, Peter Butterworth, Marcia Scazufca, Shuzo Kumagai, Sanmei Chen, Kenji Narazaki, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Antonio Lobo, Raúl Lopez-Anton, Javier Santabárbara, Perminder S Sachdev
BACKGROUND: The prevalence of dementia varies around the world, potentially contributed to by international differences in rates of age-related cognitive decline. Our primary goal was to investigate how rates of age-related decline in cognitive test performance varied among international cohort studies of cognitive aging. We also determined the extent to which sex, educational attainment, and apolipoprotein E ε4 allele (APOE*4) carrier status were associated with decline. METHODS AND FINDINGS: We harmonized longitudinal data for 14 cohorts from 12 countries (Australia, Brazil, France, Greece, Hong Kong, Italy, Japan, Singapore, Spain, South Korea, United Kingdom, United States), for a total of 42,170 individuals aged 54-105 y (42% male), including 3...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28298208/looking-back-to-move-forward-a-twenty-year-audit-of-herpes-zoster-in-asia-pacific
#4
REVIEW
Liang-Kung Chen, Hidenori Arai, Liang-Yu Chen, Ming-Yueh Chou, Samsuridjal Djauzi, Birong Dong, Taro Kojima, Ki Tae Kwon, Hoe Nam Leong, Edward M F Leung, Chih-Kuang Liang, Xiaohong Liu, Dilip Mathai, Jiun Yit Pan, Li-Ning Peng, Eduardo Rommel S Poblete, Philip J H Poi, Stewart Reid, Terapong Tantawichien, Chang Won Won
BACKGROUND: Herpes zoster (HZ) is a prevalent viral disease that inflicts substantial morbidity and associated healthcare and socioeconomic burdens. Current treatments are not fully effective, especially among the most vulnerable patients. Although widely recommended, vaccination against HZ is not routine; barriers in Asia-Pacific include long-standing neglect of adult immunisation and sparse local data. To address knowledge gaps, raise awareness, and disseminate best practice, we reviewed recent data and guidelines on HZ from the Asia-Pacific region...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28285503/development-of-urinary-bladder-pre-neoplasia-by-schistosoma-haematobium-eggs-and-chemical-carcinogen-in-mice
#5
Bayissa Chala, Min-Ho Choi, Kyung Chul Moon, Hyung Suk Kim, Cheol Kwak, Sung-Tae Hong
Schistosoma haematobium is a biocarcinogen of human urinary bladder (UB). The present study investigated developing UB cancer mouse model by injecting S. haematobium eggs into the bladder wall and introduction of chemical carcinogens. Histopathological findings showed mild hyperplasia to epithelial vacuolar change, and high grade dysplasia. Squamous metaplasia was observed in the S. haematobium eggs+NDMA group at week 12 but not in other groups. Immunohistochemistry revealed significantly high expression of Ki-67 in urothelial epithelial cells of the S...
February 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28278166/the-demanding-attention-of-tuberculosis-in-allogeneic-hematopoietic-stem-cell-transplantation-recipients-high-incidence-compared-with-general-population
#6
Hyo-Jin Lee, Dong-Gun Lee, Su-Mi Choi, Sun Hee Park, Sung-Yeon Cho, Jae-Ki Choi, Si-Hyun Kim, Jung-Hyun Choi, Jin-Hong Yoo, Byung-Sik Cho, Ki-Seong Eom, Seok Lee, Yoo-Jin Kim, Hee-Je Kim, Chang-Ki Min, Dong-Wook Kim, Jong-Wook Lee, Woo-Sung Min, Jung Im Jung
BACKGROUND: The risk of developing tuberculosis (TB) in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is expected to be relatively high in an intermediate TB burden country. This single-center retrospective study was conducted to investigate risk factors and the incidence of TB after allogeneic HSCT. METHODS: From January 2004 to March 2011, 845 adult patients were enrolled. Starting April 2009, patients were given isoniazid (INH) prophylaxis based on interferon-γ release assay results...
2017: PloS One
https://www.readbyqxmd.com/read/28276441/rna-surveillance-via-nonsense-mediated-mrna-decay-is-crucial-for-longevity-in-daf-2-insulin-igf-1-mutant-c-elegans
#7
Heehwa G Son, Mihwa Seo, Seokjin Ham, Wooseon Hwang, Dongyeop Lee, Seon Woo A An, Murat Artan, Keunhee Seo, Rachel Kaletsky, Rachel N Arey, Youngjae Ryu, Chang Man Ha, Yoon Ki Kim, Coleen T Murphy, Tae-Young Roh, Hong Gil Nam, Seung-Jae V Lee
Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/insulin/insulin-like growth factor 1 receptor. We find that daf-2 mutants display enhanced NMD activity and reduced levels of potentially aberrant transcripts...
March 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28262724/comparison-of-bone-mineral-loss-by-combined-androgen-block-agonist-versus-gnrh-in-patients-with-prostate-cancer-a-12-month-prospective-observational-study
#8
Sung Han Kim, Jae Young Joung, Sohee Kim, Koon Ho Rha, Hyeong Gon Kim, Cheol Kwak, Ji Youl Lee, Seong Soo Jeon, Sung Kyu Hong, Hyeon Jeong, Moon Ki Jo, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Choung-Soo Kim
The multi-centre, prospective, observational study was designed to examine the efficacy of continuous combined androgen block (CAB) vs. GnRH agonist monotherapy in terms of bone mineral density (BMD) change during 12 months post-androgen deprivation therapy (ADT) in Asian prostate cancer patients. Multiple regression analysis and estimated the 10-year probability of major fractures among the patients with Fracture Risk Assessment Tool were conducted to investigate the underlying factors affecting BMD. Paired t-test to evaluate the change of BMD from baseline to 12 month, and two sample t-test to examine the difference of BMD changes were used between two groups...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28256168/multidisciplinary-management-for-the-treatment-of-proximal-posterior-inferior-cerebellar-artery-aneurysms
#9
Kwang-Chun Cho, Yong Bae Kim, Sang Hyun Suh, Jin Yang Joo, Chang-Ki Hong
OBJECTIVES: Aneurysms of the proximal posterior inferior cerebellar artery (PICA) are rare. The management of proximal PICA aneurysms is challenging with either surgical or endovascular treatment. We report our successful experience of treating PICA aneurysms with a multimodal approach. METHODS: Of 2382 treated aneurysms, 22 aneurysms in 21 patients (male:female 8:13, mean age 48.9 years) were enrolled from March 1998 to December 2015. We treated the aneurysms with a multimodal approach and performed angiography to examine aneurysm regrowth at the 12 months follow-up...
March 3, 2017: Neurological Research
https://www.readbyqxmd.com/read/28248956/diversification-of-orientia-tsutsugamushi-genotypes-by-intragenic-recombination-and-their-potential-expansion-in-endemic-areas
#10
Gwanghun Kim, Na-Young Ha, Chan-Ki Min, Hong-Il Kim, Nguyen Thi Hai Yen, Keun-Hwa Lee, Inbo Oh, Jae-Seung Kang, Myung-Sik Choi, Ik-Sang Kim, Nam-Hyuk Cho
BACKGROUND: Scrub typhus is a mite-borne febrile disease caused by O. tsutsugamushi infection. Recently, emergence of scrub typhus has attracted considerable attention in several endemic countries in Asia and the western Pacific. In addition, the antigenic diversity of the intracellular pathogen has been a serious obstacle for developing effective diagnostics and vaccine. METHODOLOGY/PRINCIPAL FINDINGS: To understand the evolutionary pathway of genotypic diversification of O...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28248091/high-density-single-layer-coating-of-gold-nanoparticles-onto-multiple-substrates-by-using-an-intrinsically-disordered-protein-of-%C3%AE-synuclein-for-nanoapplications
#11
Ghibom Bhak, Junghee Lee, Chang-Hyun Kim, Dong Young Chung, Jin Hyoun Kang, Soojung Oh, Jungsup Lee, Jin Soo Kang, Ji Mun Yoo, Jee Eun Yang, Kun Yil Rhoo, Sunghak Park, Somin Lee, Ki Tae Nam, Noo Li Jeon, Jyongsik Jang, Byung Hee Hong, Yung-Eun Sung, Myung-Han Yoon, Seung R Paik
Functional graffiti of nanoparticles onto target surface is an important issue in the development of nanodevices. A general strategy has been introduced here to decorate chemically diverse substrates with gold nanoparticles (AuNPs) in the form of a close-packed single layer by using an omni-adhesive protein of α-synuclein (αS) as conjugated with the particles. Since the adsorption was highly sensitive to pH, the amino acid sequence of αS exposed from the conjugates and its conformationally disordered state capable of exhibiting structural plasticity are considered to be responsible for the single-layer coating over diverse surfaces...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28243760/switching-profiles-in-a-population-based-cohort-of-rheumatoid-arthritis-receiving-biologic-therapy-results-from-the-kobio-registry
#12
Dong-Jin Park, Sung Jae Choi, Kichul Shin, Hyoun-Ah Kim, Yong-Beom Park, Seong Wook Kang, Seung-Ki Kwok, Seong-Kyu Kim, Eon Jeong Nam, Yoon-Kyoung Sung, Jaejoon Lee, Chang Hoon Lee, Chan Hong Jeon, Shin-Seok Lee
Despite improved quality of care for rheumatoid arthritis (RA) patients, many still experience treatment failure with a biologic agent and eventually switch to another biologic agent. We investigated patterns of biologic treatment and reasons for switching biologics in patients with RA. Patients with RA who had started on a biologic agent or had switched to another biologic agent were identified from the prospective observational Korean nationwide Biologics (KOBIO) registry. The KOBIO registry contained 1184 patients with RA at the time of initiation or switching of biologic agents...
February 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28224773/novel-slc37a4-mutations-in-korean-patients-with-glycogen-storage-disease-ib
#13
Rihwa Choi, Hyung Doo Park, Jung Min Ko, Jeongho Lee, Dong Hwan Lee, Suk Jin Hong, Chang Seok Ki, Soo Youn Lee, Jong Won Kim, Junghan Song, Yon Ho Choe
BACKGROUND: Molecular techniques are fundamental for establishing an accurate diagnosis and therapeutic approach of glycogen storage diseases (GSDs). We aimed to evaluate SLC37A4 mutation spectrum in Korean GSD Ib patients. METHODS: Nine Korean patients from eight unrelated families with GSD Ib were included. SLC37A4 mutations were detected in all patients with direct sequencing using a PCR method and/or whole-exome sequencing. A comprehensive review of previously reported SLC37A4 mutations was also conducted...
May 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28224766/thromboelastographic-evaluation-of-coagulation-in-patients-with-liver-disease
#14
Kyung Hwa Shin, In Suk Kim, Hyun Ji Lee, Hyung Hoi Kim, Chulhun L Chang, Young Mi Hong, Ki Tae Yoon, Mong Cho
BACKGROUND: The aims of this study were to investigate the parameters of thromboelastography (TEG) for evaluating coagulopathy and to reveal an association with disease severity and/or transfusion requirement in patients with chronic liver disease (CLD) in a clinical laboratory setting. METHODS: We enrolled two groups of adult patients with cirrhotic (N=123) and non-cirrhotic liver disease (N=52), as well as 84 healthy controls. Reaction time (R), kinetic time (K), α-angle (α), maximal amplitude (MA), and coagulation index (CI) were measured with kaolin-activated citrated blood with the TEG 5000 system (Haemonetics Corporation, USA)...
May 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28218825/sulfur-modified-graphitic-carbon-nitride-nanostructures-as-an-efficient-electrocatalyst-for-water-oxidation
#15
Vinayak S Kale, Uk Sim, Jiwoong Yang, Kyoungsuk Jin, Sue In Chae, Woo Je Chang, Arun Kumar Sinha, Heonjin Ha, Chan-Cuk Hwang, Junghyun An, Hyo-Ki Hong, Zonghoon Lee, Ki Tae Nam, Taeghwan Hyeon
There is an urgent need to develop metal-free, low cost, durable, and highly efficient catalysts for industrially important oxygen evolution reactions. Inspired by natural geodes, unique melamine nanogeodes are successfully synthesized using hydrothermal process. Sulfur-modified graphitic carbon nitride (S-modified g-CN x ) electrocatalysts are obtained by annealing these melamine nanogeodes in situ with sulfur. The sulfur modification in the g-CN x structure leads to excellent oxygen evolution reaction activity by lowering the overpotential...
February 20, 2017: Small
https://www.readbyqxmd.com/read/28217675/clinicopathologic-evaluation-of-myofibroblastoma-a-study-in-two-hospitals
#16
Seul Ki Kim, Ji Sun Lee, Su Been Hong, Jung Ryeol Lee, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim
OBJECTIVE: To report various anatomic locations and clinical characteristics of pathologically proven myofibroblastoma in Koran patients. METHODS: Pathologic reports of patients who underwent surgeries at two centers between April 2003 and March 2016 were retrieved from the electronic medical record system of the hospital. Pathologic reports were included after performing a search using the keyword "myofibroblastoma". RESULTS: The cohort consisted of 11 subjects and included eight female and three male individuals...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28217673/in-vitro-fertilization-outcomes-in-women-with-surgery-induced-diminished-ovarian-reserve-after-endometrioma-operation-comparison-with-diminished-ovarian-reserve-without-ovarian-surgery
#17
Su Been Hong, Na Ra Lee, Seul Ki Kim, Hoon Kim, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Young Min Choi
OBJECTIVE: To compare the in vitro fertilization (IVF) outcomes between women with diminished ovarian reserve (DOR) after endometrioma operation and women with DOR without ovarian surgery. METHODS: This retrospective case-control study included 124 women aged under 40 and had DOR (serum anti-Müllerian hormone level <1.1 ng/mL or antral follicle count ≤6). They participated in fresh first and/or second IVF cycles between March in 2010 and December in 2015. Basal characteristics and IVF outcomes were compared between 47 cycles (32 women) with surgery-induced DOR and 119 cycles (92 women) with DOR without ovarian surgery...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28215591/the-effect-of-resuscitation-position-on-cerebral-and-coronary-perfusion-pressure-during-mechanical-cardiopulmonary-resuscitation-in-porcine-cardiac-arrest-model
#18
Taeyun Kim, Sang Do Shin, Kyoung Jun Song, Yong Joo Park, Hyun Ho Ryu, Guillaume Debaty, Keith Lurie, Ki Jeong Hong
OBJECTIVE: It is unknown whether patient position is associated with the optimal cerebral (CePP) and coronary (CoPP) perfusion pressure. METHODS: This study utilized a randomized experimental design and anesthetized, intubated and paralyzed female pigs (n=12) (mean 42, SD 3kg). After 6min of untreated ventricular fibrillation, mechanical CPR with was performed for 3min in 0° supine position. The CPR was then performed for 5min in a position randomly assigned to either 1) head-up tilt (HUT) by three angles (30°, 45°, or 60°) or 2) head-down tilt (HDT) by three angles (30°, 45°, or 60°) and at 3) supine position between HUT and HDT positions...
February 16, 2017: Resuscitation
https://www.readbyqxmd.com/read/28210852/treatment-of-rectovaginal-fistula-with-gracilis-muscle-flap-transposition-long-term-follow-up
#19
Seong Oh Park, Ki Yong Hong, Kyo Joo Park, Hak Chang, Jin Yong Shin, Seung-Yong Jeong
PURPOSE: Rectovaginal fistulas are difficult to treat completely, especially when patients present with a history of multiple surgeries and radiation therapy. We aimed to evaluate the efficacy of gracilis muscle flap transposition to treat rectovaginal fistula. METHODS: We performed a retrospective chart review of all gracilis muscle transposition cases and other procedures between January 2009 and July 2016. RESULTS: Total 53 cases were reviewed...
February 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28208711/antidepressant-effects-of-aripiprazole-augmentation-for-cilostazol-treated-mice-exposed-to-chronic-mild-stress-after-ischemic-stroke
#20
Yu Ri Kim, Ha Neui Kim, Ki Whan Hong, Hwa Kyoung Shin, Byung Tae Choi
The aim of this study was to determine the effects and underlying mechanism of aripiprazole (APZ) augmentation for cilostazol (CLS)-treated post-ischemic stroke mice that were exposed to chronic mild stress (CMS). Compared to treatment with either APZ or CLS alone, the combined treatment resulted in a greater reduction in depressive behaviors, including anhedonia, despair-like behaviors, and memory impairments. This treatment also significantly reduced atrophic changes in the striatum, cortex, and midbrain of CMS-treated ischemic mice, and inhibited neuronal cell apoptosis, particularly in the striatum and the dentate gyrus of the hippocampus...
February 8, 2017: International Journal of Molecular Sciences
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