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Hong, Chang-Ki

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https://www.readbyqxmd.com/read/28066143/acepromazine-inhibits-herg-potassium-ion-channels-expressed-in-human-embryonic-kidney-293-cells
#1
Young Shin Joo, Hong Joon Lee, Jin-Sung Choi, Ki-Wug Sung
The effects of acepromazine on human ether-à-go-go-related gene (hERG) potassium channels were investigated using whole-cell voltage-clamp technique in human embryonic kidney (HEK293) cells transfected with hERG. The hERG currents were recorded with or without acepromazine, and the steady-state and peak tail currents were analyzed for the evaluating the drug effects. Acepromazine inhibited the hERG currents in a concentration-dependent manner with an IC50 value of 1.5 µM and Hill coefficient of 1.1. Acepromazine blocked hERG currents in a voltage-dependent manner between -40 and +10 mV...
January 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28057081/the-efficacy-and-safety-of-co-administration-of-fimasartan-and-rosuvastatin-to-patients-with-hypertension-and-dyslipidemia
#2
Moo-Yong Rhee, Taehoon Ahn, Kiyuk Chang, Shung Chull Chae, Tae-Hyun Yang, Wan Joo Shim, Tae Soo Kang, Jae-Kean Ryu, Deuk-Young Nah, Tae-Ho Park, In-Ho Chae, Seung Woo Park, Hae-Young Lee, Seung-Jea Tahk, Young Won Yoon, Chi Young Shim, Dong-Gu Shin, Hong Seog Seo, Sung Yun Lee, Doo Il Kim, Jun Kwan, Seung-Jae Joo, Myung Ho Jeong, Jin-Ok Jeong, Ki Chul Sung, Seok Yeon Kim, Sang-Hyun Kim, Kook-Jin Chun, Dong Joo Oh
BACKGROUND: Hypertension and dyslipidemia are major risk factors of cardiovascular disease (CVD) events. The objective of this study was to evaluate the efficacy and safety of the co-administration of fimasartan and rosuvastatin in patients with hypertension and hypercholesterolemia. METHODS: We conducted a randomized double-blind and parallel-group trial. Patients who met eligible criteria after 4 weeks of therapeutic life change were randomly assigned to the following groups...
January 5, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28043099/guidelines-for-the-surgical-management-of-laryngeal-cancer-korean-society-of-thyroid-head-and-neck-surgery
#3
Soon-Hyun Ahn, Hyun Jun Hong, Soon Young Kwon, Kee Hwan Kwon, Jong-Lyel Roh, Junsun Ryu, Jun Hee Park, Seung-Kuk Baek, Guk Haeng Lee, Sei Young Lee, Jin Choon Lee, Man Ki Chung, Young Hoon Joo, Yong Bae Ji, Jeong Hun Hah, Minsu Kwon, Young Min Park, Chang Myeon Song, Sung-Chan Shin, Chang Hwan Ryu, Doh Young Lee, Young Chan Lee, Jae Won Chang, Ha Min Jeong, Jae-Keun Cho, Wonjae Cha, Byung Joon Chun, Ik Joon Choi, Hyo Geun Choi, Kang Dae Lee
Objectives: Korean Society of Thyroid-Head and Neck Surgery appointed a Task Force to develop clinical practice guidelines for the surgical treatment of laryngeal cancer. Methods: This Task Force conducted a systematic search of the EMBASE, MEDLINE, Cochrane Library, and KoreaMed databases to identify relevant articles, using search terms selected according to the key questions. Evidence-based recommendations were then created on the basis of these articles. An external expert review and Delphi questionnaire were applied to reach consensus regarding the recommendations...
January 3, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28012648/impact-of-vasomotion-type-on-prognosis-of-coronary-artery-spasm-induced-by-acetylcholine-provocation-test-of-left-coronary-artery
#4
Eun Mi Lee, Man Ho Choi, Hong Seog Seo, Hyun Ki Kim, Nam-Ho Kim, Cheol Ung Choi, Jin Won Kim, Hong Euy Lim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Dong Joo Oh
BACKGROUND AND AIMS: The impact of vasomotion types on long-term clinical outcomes in patients with coronary artery spasm (CAS) induced by the acetylcholine provocation test (ACH-test) remains unclear. METHODS: We evaluated 4644 consecutive patients with typical resting chest pain (CP), but no angiographically significant coronary artery lesion (<50% stenosis), who underwent an ACH-test. According to their vasomotor response, patients were categorized into four types: normal vasomotion (no CP, no ischemic electrocardiographic changes, and no vasoconstriction), microvascular spasm (CP with <75% vasoconstriction but with CP relief after nitroglycerin infusion), epicardial spasm (CP with ≥75% vasoconstriction), and ACH-test inconclusive (vasoconstriction and/or electrocardiographic changes, but no CP)...
September 16, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28011608/mycobacterial-characteristics-and-treatment-outcomes-in-mycobacterium-abscessus-lung-disease
#5
Won-Jung Koh, Byeong-Ho Jeong, Su-Young Kim, Kyeongman Jeon, Kyoung Un Park, Byung Woo Jhun, Hyun Lee, Hye Yun Park, Dae Hun Kim, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Seung-Heon Lee, Chang Ki Kim, Sung Jae Shin, Charles L Daley, Hojoong Kim, O Jung Kwon
: Several mycobacterial characteristics, including colony morphotype, susceptibility to macrolide antibiotics, and T28C substitution in the erm(41) gene, are helpful in predicting the treatment responses of patients with Mycobacterium abscessus lung disease. Treatment failures and recurrences are frequently caused by reinfection. BACKGROUND: Treatment outcomes of patients with Mycobacterium abscessus subspecies abscessus lung disease are poor, and the microbial characteristics associated with treatment outcomes have not been studied systematically...
November 10, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28010876/central-ghrelin-resistance-permits-the-overconsolidation-of-fear-memory
#6
Elia S Harmatz, Lauren Stone, Seh Hong Lim, Graham Lee, Anna McGrath, Barbara Gisabella, Xiaoyu Peng, Eliza Kosoy, Junmei Yao, Elizabeth Liu, Nuno J Machado, Veronica S Weiner, Warren Slocum, Rodrigo A Cunha, Ki A Goosens
BACKGROUND: There are many contradictory findings about the role of the hormone ghrelin in aversive processing, with studies suggesting that ghrelin signaling can both inhibit and enhance aversion. Here, we characterize and reconcile the paradoxical role of ghrelin in the acquisition of fearful memories. METHODS: We used enzyme-linked immunosorbent assay to measure endogenous acyl-ghrelin and corticosterone at time points surrounding auditory fear learning. We used pharmacological (systemic and intra-amygdala) manipulations of ghrelin signaling and examined several aversive and appetitive behaviors...
November 29, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28007485/viral-hemorrhagic-septicemia-virus-vhsv-infection-mediated-sequential-changes-in-micrornas-profile-of-epithelioma-papulosum-cyprini-epc-cells
#7
Abdellaoui Najib, Min Sun Kim, Ki Hong Kim
MicroRNAs are small non-coding RNAs and are involved in the regulation of wide biological processes. Viral hemorrhagic septicemia virus (VHSV) is the causative agent of viral hemorrhagic septicemia (VHS) disease causing a heavy loss in aquaculture farms. In this study, we tried to explore the effect of VHSV infection on microRNAs profile of Epithelioma papulosum cyprini (EPC) cells at different points of time (0, 3, 12, 24, and 48 h post infection). A total of 355 conserved microRNAs and 3 novel microRNAs were identified, and among them, 103 microRNAs were differentially expressed...
December 20, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27969901/tct-534-fractional-flow-reserve-and-cardiac-events-in-coronary-artery-disease-data-from-prospective-registry
#8
Jung-Min Ahn, Min Soo Cho, Se Hun Kang, Duk-Woo Park, Eun-Seok Shin, Bon-Kwon Koo, Chang-Wook Nam, Joon Hyung Doh, June Hong Kim, In Ho Chae, Junghan Yoon, Sung-Ho Her, Ki-Bae Seung, Woo-Young Chung, Sang-Yong Yoo, Jin Bae Lee, Si Wan Choi, Kyungil Park, TaekJong Hong, Sang Yeub Lee, Pil Hyung Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27911930/the-therapeutic-response-of-gastrointestinal-stromal-tumors-to-imatinib-treatment-assessed-by-intravoxel-incoherent-motion-diffusion-weighted-magnetic-resonance-imaging-with-histopathological-correlation
#9
Feng Pan, Jie Den, Chunfang Zhang, He Wang, Jin Cheng, Weizhen Wu, Nan Hong, Yi Wang
PURPOSE: To exploit the intravoxel incoherent motion (IVIM) diffusion-weighted (DW) MRI when evaluating the therapeutic response of gastrointestinal stromal tumors (GIST) to Imatinib in a mouse model. MATERIALS AND METHODS: Mice with xenografts bearing cells from the GIST-T1 cell line were randomly divided into a treated group receiving Imatinib and a control group. DWMRI scans with 14 b-values (0-1500 s/mm2) were performed before and after treatment (days 1, 3 and 7)...
2016: PloS One
https://www.readbyqxmd.com/read/27896244/adaptive-responses-of-cardiac-function-to-fetal-postural-change-as-gestational-age-increases
#10
Woo Jin Kim, Hye Jin Choi, Sun Young Yang, Boo Hae Koo, Ki Hoon Ahn, Geum Joon Cho, Soon Cheol Hong, Min-Jeong Oh, Hai-Joong Kim
OBJECTIVE: The cardiovascular system maintains homeostasis through a series of adaptive responses to physiological requirements. However, little is known about the adaptation of fetal cardiac function to gravity, according to gestational age. In the present study, we aimed to evaluate the adaptive responses of cardiac function to postural changes, using Tei index measurements. METHODS: Fetal echocardiography and Doppler examination were performed on 114 women with vertex singleton pregnancies at 19 to 40 weeks' gestation...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27891517/prognostic-significance-of-preoperative-neutrophil-to-lymphocyte-ratio-in-nonmetastatic-renal-cell-carcinoma-a-large-multicenter-cohort-analysis
#11
Seok-Soo Byun, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Hyeon Hoe Kim, Cheol Kwak, Yong-June Kim, Won Ki Lee
Background. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers. The objective of our study was to assess the prognostic significance of preoperative NLR in non-mRCC, based on a large, multicenter cohort analysis. Methods. Totally, 1,284 non-mRCC patients undergoing surgery were enrolled from six institutions between 2000 and 2014. Recurrence-free survival (RFS) and cancer-specific survival (CSS) were calculated, and the prognostic significance of NLR was evaluated...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27867565/changes-in-cholesterol-level-correlate-with-the-course-of-pulmonary-nontuberculous-mycobacterial-disease
#12
Ji Young Hong, Go Eun Yang, Yousang Ko, Yong Bum Park, Yun Su Sim, Sung Hoon Park, Chang Youl Lee, Ki-Suck Jung, Myung Goo Lee
BACKGROUND: Nutritional assessment is important in patients with pulmonary nontuberculous mycobacterial (PNTM) disease. The therapeutic effect of a cholesterol-rich diet in tuberculosis (TB) patients has been demonstrated, but the role of cholesterol in PNTM disease is unclear. This study evaluated the sequential changes in nutritional markers, including cholesterol, total lymphocyte count and visceral fat volume, according to the PNTM disease course. METHODS: This was an age-, sex- and number of comorbid diseases-matched case-control analysis of 89 patients with PNTM disease and 356 controls, who were participants in a Korean national survey...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27863451/cerebral-white-matter-abnormalities-in-patients-with-charcot-marie-tooth-disease
#13
Mina Lee, Chang-Hyun Park, Hwa-Kyung Chung, Hyeon Jin Kim, Yunseo Choi, Jeong Hyun Yoo, Young Chul Yoon, Young Bin Hong, Ki Wha Chung, Byung-Ok Choi, Hyang Woon Lee
Here, we report the structural evidence of cerebral white matter abnormalities in Charcot-Marie-Tooth (CMT) patients and the relationship between these abnormalities and clinical disability. Brain diffusion tensor imaging (DTI) was performed in CMT patients with demyelinating (CMT1A/CMT1E), axonal (CMT2A/CMT2E), or intermediate (CMTX1/DI-CMT) peripheral neuropathy. Although all patients had normal brain MRI, all genetic subgroups except CMT1A had abnormal DTI findings indicative of significant cerebral white matter abnormalities: decreased fractional anisotropy and axial diffusivity, and increased radial diffusivity...
November 18, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27861860/oral-toxicity-of-cold-plasma-treated-edible-films-for-food-coating
#14
Sung Hee Han, Hyung Joo Suh, Ki Bae Hong, Su Yeon Kim, Sea C Min
No prior research has investigated whether the cold plasma treatment (CPT) resulted in the formation of toxic compounds. Therefore, this study carried out the experiment to check the safety of edible films treated with cold plasma by examining their acute and subacute oral toxicity in a rat model. Single-dose acute (5000 mg/kg body weight) and 14-d subacute (1000 mg/kg body weight/day) oral toxicity of cold plasma-treated edible films was assessed for male and female Sprague-Dawley (SD) rats. Rats administered 5000 mg/kg of edible film did not show the signs of acute toxicity or death after 14 d of observation...
December 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27857932/the-neck-and-posterior-fossa-combined-penetrating-injury-a-case-report
#15
Hyun Jin Han, Jun Ho Jung, Chang Ki Hong, Yong Bae Kim
Here we report a case of penetrating neck injury to the posterior fossa that was shown, using high-resolution computed tomography (HRCT) and digital subtraction angiography (DSA), to involve no vascular injury. A 54-year-old man was brought to the emergency department after a penetrating injury to the left side of the posterior neck and occipital area with a knife. He was in an intoxicated state and could not communicate readily. On initial examination, his vital signs were stable and there was no active bleeding from the penetrating site...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27853944/impact-of-control-of-blood-glucose-level-during-treatment-of-sudden-deafness-in-diabetics-relationship-with-prognosis
#16
Sang-Ki Min, Ji-Ho Shin, Mun-Young Chang, Hyun-Jin Min, Kyung-Soo Kim, Sei-Young Lee, Hoon-Shik Yang, Young-Ho Hong, Seog-Kyun Mun
The objective of this study is to investigate the impact of control of blood glucose level during treatment of sudden deafness. A retrospective study was performed involving 197 patients from January, 2011 to September, 2015. All patients were administrated prednisolone (Pharmaprednisolone tab(®), 5 mg/T; KoreaPharma) p.o under the following regimen: 60 mg/day for 4 days, 40 mg/day for 2 days, 30 mg/day for 1 day, 20 mg/day for 1 day, and 10 mg/day for 2 days. During treatment, pure tone audiometry and blood glucose level were investigated for each patient and the results were statistically analyzed...
November 16, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27847763/preliminary-experience-with-vascular-plugs-for-parent-artery-occlusion-of-the-carotid-or-vertebral-arteries
#17
Woosung Lee, Yong Sam Shin, Kyung Hyun Kim, Yong Bae Kim, Chang-Ki Hong, Joonho Chung
OBJECTIVE: The purpose of this study was to report the authors' preliminary experience using the Amplatzer Vascular Plug (AVP) (St. Jude Medical, Plymouth, MN, USA) for parent artery occlusion of the internal carotid artery (ICA) or vertebral artery (VA). MATERIALS AND METHODS: Between September 2008 and December 2015, we performed 52 therapeutic parent artery occlusions (PAOs) by an endovascular technique. Among them, 10 patients underwent PAO of the carotid or vertebral arteries using AVPs...
September 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/27824924/statin-intensity-and-clinical-outcome-in-patients-with-stable-coronary-artery-disease-and-very-low-ldl-cholesterol
#18
Soo Youn Lee, Seung-Jin Oh, Eung Ju Kim, Chi-Yoon Oum, Sung Hwan Park, Jaewon Oh, Jung-Sun Kim, Byeong-Keuk Kim, Sungha Park, Hyuk-Jae Chang, Geu-Ru Hong, Young-Guk Ko, Seok-Min Kang, Donghoon Choi, Jong-Won Ha, Myeong-Ki Hong, Yangsoo Jang, Namsik Chung, Sang-Hak Lee
BACKGROUND: Although intensive statin therapy is recommended for high risk patients, evidence of its benefit in patients with stable coronary artery disease (CAD) and very low low-density lipoprotein-cholesterol (LDL-C) has been very rare. In this study, we investigated whether higher statin intensity reduces cardiovascular risks in this population. METHODS: In this retrospective study, a total of 5234 patients with stable CAD were screened at three tertiary hospitals in Korea; 449 patients (mean age: 65 years, male: 69%) with LDL-C <80 mg/dL were finally analyzed...
2016: PloS One
https://www.readbyqxmd.com/read/27822931/clinical-outcomes-in-patients-with-deferred-coronary-lesions-according-to-disease-severity-assessed-by-fractional-flow-reserve
#19
Ki Bum Won, Chang Wook Nam, Yun Kyeong Cho, Hyuck Jun Yoon, Hyoung Seob Park, Hyungseop Kim, Seongwook Han, Seung Ho Hur, Yoon Nyun Kim, Sang Hyun Park, Jung Kyu Han, Bon Kwon Koo, Hyo Soo Kim, Joon Hyung Doh, Sung Yun Lee, Hyoung Mo Yang, Hong Seok Lim, Myeong Ho Yoon, Seung Jea Tahk, Kwon Bae Kim
Data on the clinical outcomes in deferred coronary lesions according to functional severity have been limited. This study evaluated the clinical outcomes of deferred lesions according to fractional flow reserve (FFR) grade using Korean FFR registry data. Among 1,294 patients and 1,628 lesions in Korean FFR registry, 665 patients with 781 deferred lesions were included in this study. All participants were consecutively categorized into 4 groups according to FFR; group 1: ≥ 0.96 (n = 56), group 2: 0.86-0.95 (n = 330), group 3: 0...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27800002/single-stage-operation-for-giant-schwannoma-at-the-craniocervical-junction-with-minimal-laminectomy-a-case-report-and-literature-review
#20
Sun Yoon, Hunho Park, Kyu-Sung Lee, Seoung Woo Park, Chang-Ki Hong
Here we report a single-stage operation we performed on a patient with a large schwannoma that extended from the lower clivus to the cervico-thoracic junction caudally. A number of authors have previously performed multilevel laminectomy to remove giant schwannomas that extend for considerable length. This technique has caused cervical instability such as kyphosis or gooseneck deformity on several occasions. We removed the tumor with a left lateral suboccipital craniectomy with laminectomy only at C1 and without any subsequent surgery-related neurologic deficits...
September 2016: Korean Journal of Spine
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