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https://www.readbyqxmd.com/read/29333578/insulin-resistance-and-bone-a-biological-partnership
#1
Caterina Conte, Solomon Epstein, Nicola Napoli
Despite a clear association between type 2 diabetes (T2D) and fracture risk, the pathogenesis of bone fragility in T2D has not been clearly elucidated. Insulin resistance is the primary defect in T2D. Insulin signalling regulates both bone formation and bone resorption, but whether insulin resistance can affect bone has not been established. On the other hand, evidence exists that bone might play a role in the regulation of glucose metabolism. This article reviews the available experimental and clinical evidence on the interplay between bone and insulin resistance...
January 15, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29331975/is-postoperative-bracing-after-pedicle-screw-fixation-of-spine-fractures-necessary-study-protocol-of-the-ornot-study-a-randomised-controlled-multicentre-trial
#2
Arjen Johannes Smits, Jaap Deunk, Agnita Stadhouder, Mark Cornelis Altena, Diederik Hendrik Ruth Kempen, Frank Willem Bloemers
INTRODUCTION: The most common surgical treatment of traumatic spine fractures is through a posterior approach using pedicle screws and rods. Postoperative treatment protocols including the use of postoperative orthoses however differ between hospitals and surgeons. A three-point hyperextension orthosis is designed to support proper posture and unload the anterior column. Some motion remains when wearing an orthosis, and its main value in postoperative treatment is therefore believed to be pain relief and patient confidence...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29330342/are-the-patient-rated-wrist-evaluation-prwe-and-the-disabilities-of-the-arm-shoulder-and-hand-dash-questionnaire-used-in-distal-radial-fractures-truly-valid-and-reliable
#3
Y V Kleinlugtenbelt, R G Krol, M Bhandari, J C Goslings, R W Poolman, V A B Scholtes
OBJECTIVES: The patient-rated wrist evaluation (PRWE) and the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire are patient-reported outcome measures (PROMs) used for clinical and research purposes. Methodological high-quality clinimetric studies that determine the measurement properties of these PROMs when used in patients with a distal radial fracture are lacking. This study aimed to validate the PRWE and DASH in Dutch patients with a displaced distal radial fracture (DRF)...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29329713/baseline-and-pre-operative-1-year-mortality-risk-factors-in-a-cohort-of-509-hip-fracture-patients-consecutively-admitted-to-a-co-managed-orthogeriatric-unit-fonda-cohort
#4
Rocío Menéndez-Colino, Teresa Alarcon, Pilar Gotor, Rocío Queipo, Raquel Ramírez-Martín, Angel Otero, Juan I González-Montalvo
INTRODUCTION: The aim of this study was to determine the patient characteristics that predict 1-year mortality after a hip fracture (HF). METHODS: All patients admitted consecutively with fragility HF during 1 year in a co-managed orthogeriatric unit of a university hospital (FONDA cohort) were assesed. Baseline and admission demographic, clinical, functional, analytical and body-composition variables were collected in the first 72 h after admission. A protocol designed to minimize the consequences of the HF was applied...
January 6, 2018: Injury
https://www.readbyqxmd.com/read/29328790/hospital-stay-and-blood-transfusion-in-elderly-patients-with-hip-fractures
#5
Efthymios Iliopoulos, Sohail Yousaf, Hazel Watters, Arshad Khaleel
Neck of femur (NOF) fractures in elderly patients are the most frequent condition which an orthopaedic surgeon confronts nowadays. The incidence of these fractures is increasing as the population continues to age. These patients absorb the majority of the resources in the hospitals, as their healthcare demands are increased. This study included all patients who were admitted to our hospital between January and October 2015 following a neck of femur fracture. A total of 336 patients were included (72.3% female)...
December 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29327552/-treatment-of-irreducible-gartland-typeiii-humerus-supracondylar-fracture-in-children-with-limited-open-reduction-and-percutaneous-k-wire-internal-fixation
#6
Xin Li, Hong Liu, Sheng Xiao, Ke Fang, Jie Wen
OBJECTIVE: To investigate the clinical outcomes of limited open reduction and percutaneous K-wire internal fixation for the treatment of irreducible Gartland type III humerus supracondylar fracture in children. METHODS: From May 2006 to October 2014, 132 patients with irreducible Gartland type III humerus supracondylar fracture were treated with reduction and percutaneous K-wire internal fixation. The reduction was performed with the guiding of surgeon's finger, and the lateral approach with periosteum torn was chosen according to the shift direction of the distal fractures...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29325026/failure-of-sternal-wires-depends-on-the-number-of-turns-and-plastic-deformation-combined-experimental-and-computational-approach
#7
Lukas Capek, Petr Henys, Martin Kalab, Pavel Solfronk
OBJECTIVES: The number of turns at the end of a wire closure is not described or discussed in any cardiosurgical guidelines. The hands-on experience of the surgeon plays a significant role. The aim of this work was to clarify the relationship between the number of turns of the suture and the resulting strength of the sternal fixation. METHODS: The study was performed in 2 independent steps. The first step was a finite element simulation, where the stress and strain distribution of the sternal fixation was observed...
January 8, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29324529/inappropriately-timed-pediatric-orthopaedic-referrals-from-the-emergency-department-result-in-unnecessary-appointments-and-financial-burden-for-patients
#8
Taylor J Jackson, Todd J Blumberg, Apurva S Shah, Wudbhav N Sankar
BACKGROUND: Musculoskeletal injuries are among the most common reasons for emergency department (ED) visits in the pediatric population. Many such injuries can be managed with a single follow-up outpatient visit. However, untimely (ie, premature) referrals by emergency physicians to orthopaedic surgeons are common and may inadvertently create need for a second visit, generating unnecessary expenditures. We sought to elucidate the cost of premature musculoskeletal follow-up visits to the patients, families, and the health care system...
January 10, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29322889/outcomes-of-open-reduction-and-internal-fixation-in-displaced-intra-articular-scapular-fractures-a-case-series
#9
M Zahid, E H Rashid, H Inam, A J Zubairi, N Baloch, P M Hashmi
Scapular fractures are rare injuries and usually occur due to high energy trauma. Displaced Intra articular fractures usually require operative treatment and yields better outcomes as compared to conservative management. To assess the functional and radiological outcomes of displaced intra-articular scapular fractures managed with open reduction and internal fixation. 12 patients were retrospectively reviewed and included in the study. Post-operative functional outcomes were assessed using mean quick DASH (Disability of arm, hand and shoulder) score while radiological outcomes were analyzed as percentage of implant cut-through, mal-union, non-union or infection...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29322887/functional-outcome-after-proximal-humerus-fracture-fixation-understanding-the-risk-factors
#10
A Christiano, P Pean, S Konda, Z K Egol
The purpose is to identify risk factors of functional outcome following proximal humerus open reduction and internal fixation. Patients treated for proximal humerus fractures with open reduction and internal fixation were enrolled in a prospective data registry. Patients were evaluated for function using the Disability of the Arm, Shoulder and Hand score for 12 months and as available beyond 12 months. Univariate analyses were conducted to identify variables associated with functional outcome. Significant variables were included in a multivariate regression predicting functional outcome...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29319570/analysis-of-operative-techniques-of-fractures-of-the-first-metacarpal-base
#11
Till Fischborn, Dominik Beckenbauer, Manuel Held, Adrien Daigeler, Fabian Medved
INTRODUCTION: Over time, the operative treatment of extra-articular and intra-articular fractures of the first metacarpal base has gained significant importance, and at present, there are many operative strategies available because of the different osteosynthesis procedures in practice today. PURPOSE: In this retrospective cohort study, we analyze the possible differences between 2 distinguished operative osteosynthesis techniques, in terms of patient outcome, operation time, duration of radiation exposure, and postoperative radiographic results...
January 9, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29319352/dual-antegrade-intramedullary-headless-screw-fixation-for-treatment-of-unstable-proximal-phalanx-fractures
#12
Michael P Gaspar, Shiv D Gandhi, Randall W Culp, Patrick M Kane
BACKGROUND: Although intramedullary headless screw (IMHS) fixation is a promising minimally invasive surgical treatment option for unstable proximal phalanx fractures, a single IMHS may provide inadequate fixation for certain fracture patterns. The purpose of this study was to evaluate the short-term clinical outcomes in a pilot series of patients with proximal phalanx fractures treated with dual antegrade IMHS fixation. METHODS: We performed a retrospective chart review of proximal phalanx fractures treated with dual antegrade IMHS fixation with a minimum 1 year of follow-up...
January 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29313844/large-scale-gwas-identifies-multiple-loci-for-hand-grip-strength-providing-biological-insights-into-muscular-fitness
#13
Sara M Willems, Daniel J Wright, Felix R Day, Katerina Trajanoska, Peter K Joshi, John A Morris, Amy M Matteini, Fleur C Garton, Niels Grarup, Nikolay Oskolkov, Anbupalam Thalamuthu, Massimo Mangino, Jun Liu, Ayse Demirkan, Monkol Lek, Liwen Xu, Guan Wang, Christopher Oldmeadow, Kyle J Gaulton, Luca A Lotta, Eri Miyamoto-Mikami, Manuel A Rivas, Tom White, Po-Ru Loh, Mette Aadahl, Najaf Amin, John R Attia, Krista Austin, Beben Benyamin, Søren Brage, Yu-Ching Cheng, Paweł Cięszczyk, Wim Derave, Karl-Fredrik Eriksson, Nir Eynon, Allan Linneberg, Alejandro Lucia, Myosotis Massidda, Braxton D Mitchell, Motohiko Miyachi, Haruka Murakami, Sandosh Padmanabhan, Ashutosh Pandey, Ioannis Papadimitriou, Deepak K Rajpal, Craig Sale, Theresia M Schnurr, Francesco Sessa, Nick Shrine, Martin D Tobin, Ian Varley, Louise V Wain, Naomi R Wray, Cecilia M Lindgren, Daniel G MacArthur, Dawn M Waterworth, Mark I McCarthy, Oluf Pedersen, Kay-Tee Khaw, Douglas P Kiel, Yannis Pitsiladis, Noriyuki Fuku, Paul W Franks, Kathryn N North, Cornelia M van Duijn, Karen A Mather, Torben Hansen, Ola Hansson, Tim Spector, Joanne M Murabito, J Brent Richards, Fernando Rivadeneira, Claudia Langenberg, John R B Perry, Nick J Wareham, Robert A Scott
Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10-8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1)...
July 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29311022/three-dimensional-titanium-miniplates-for-fixation-of-subcondylar-mandibular-fractures-comparison-of-five-designs-using-patient-specific-finite-element-analysis
#14
Mhd Hassan Albogha, Yoshihide Mori, Ichiro Takahashi
PURPOSE: The purpose of the current study is to compare the performance of five designs of three-dimensional titanium miniplates (lambda, strut, delta, rhombic and trapezoid) for fixation of subcondylar mandibular fracture. MATERIALS AND METHODS: Three-dimensional models were constructed for the five miniplates with their screws and integrated into a virtually fractured mandible that was derived from a computed tomographic image of living human. Patient-specific finite element models were analyzed to compare the performances of the miniplates...
December 26, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29306577/diaphyseal-forearm-fractures-20-years-after-surgical-treatment-is-there-still-an-indication-for-percutaneous-fixation
#15
M R Fernández-Marín, M Hidalgo-Pérez, G Arias-Rodríguez, A García-Mendoza, E Prada-Chamorro, G Domecq-Fernández de Bobadilla
OBJECTIVE: This is a retrospective study of 98 diaphyseal forearm fractures in adults, treated by a percutaneous technique with intramedullar Kirchner wires. MATERIALS AND METHOD: We reviewed 64 patients with 98 forearm fractures with a radiographic follow-up, assessing the presence of pseudarthrosis or delayed bone union and evaluating functional outcomes with the Anderson and the Disability of the Arm, Shoulder and Hand scale. RESULTS: Clinical and radiological bone union was achieved in an average of 12 weeks...
January 3, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29303973/effect-of-lithium-disilicate-reinforced-liner-treatment-on-bond-and-fracture-strengths-of-bilayered-zirconia-all-ceramic-crown
#16
Yong-Seok Jang, Hyeong-Rok Noh, Min-Ho Lee, Myung-Jin Lim, Tae-Sung Bae
This study was performed to evaluate the effect of a lithium-disilicate spray-liner application on both the bond strength between zirconia cores and heat-pressed lithium-disilicate glass-ceramic veneers, and the fracture strength of all-ceramic zirconia crowns. A lithium-disilicate reinforced liner was applied on the surface of a zirconia core and lithium-disilicate glass-ceramic was veneered on zirconia through heat press forming. Microtensile and crown fracture tests were conducted in order to evaluate, respectively, the bonding strength between the zirconia cores and heat pressed lithium-disilicate glass-ceramic veneers, and the fracture strength of bilayered zirconia all-ceramic crowns...
January 5, 2018: Materials
https://www.readbyqxmd.com/read/29302987/an-investigation-of-factors-influencing-high-usage-of-medical-and-long-term-care-services-in-an-aging-society-in-japan
#17
Kana Kazawa, Md Moshiur Rahman, Michiko Moriyama
Medical and long-term care costs are increasing all over the world. In this study, we investigated the characteristics of groups with high cost of medical and long-term care to define targets for curbing social security costs. As a result, for the population covered by the National Health Insurance, a large portion of medical costs were incurred for mental disorders, malignant neoplasms, and lifestyle-related diseases. For those covered by the Late Elderly Health Insurance System, most medical costs were incurred for lifestyle-related diseases, femoral fractures, neurological diseases, mental disorders, pneumonia, malignant neoplasms, and Alzheimer's disease...
January 1, 2018: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29301797/management-of-a-15-year-old-scaphoid-non-union
#18
Kai Yuen Wong, Olivia Sharp, Phillip Johnston
Scaphoid non-union affects wrist joint function and is often associated with a predictable pattern of degenerative change. A 30-year-old man presented with a symptomatic 15-year-old right scaphoid fracture with secondary scaphoid non-union advanced collapse of his right wrist. There was no evidence of avascular necrosis. The initial injury was from a fall onto his outstretched hand. We performed a right scaphoid open reduction, internal fixation and iliac crest bone graft. One year after the operation, the patient had good wrist function and grip strength...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29290007/bone-geometry-quality-and-bone-markers-in-children-with-type-1-diabetes-mellitus
#19
Roberto Franceschi, Silvia Longhi, Vittoria Cauvin, Angelo Fassio, Giuseppe Gallo, Fiorenzo Lupi, Petra Reinstadler, Antonio Fanolla, Davide Gatti, Giorgio Radetti
Adults with Type 1 diabetes mellitus show a high risk of bone fracture, probably as a consequence of a decreased bone mass and microarchitectural bone alterations. The aim of the study was to investigate the potential negative effects of type 1 diabetes on bone geometry, quality, and bone markers in a group of children and adolescents. 96 children, mean age 10.5 ± 3.1 years, agreed to participate to the study. Bone geometry was evaluated on digitalized X-rays at the level of the 2nd metacarpal bone. The following parameters were investigated and expressed as SDS: outer diameter (D), inner diameter (d), cortical area (CA), and medullary area (MA)...
December 30, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29287662/the-influence-of-local-bone-quality-on-fracture-pattern-in-proximal-humerus-fractures
#20
Ruben A Mazzucchelli, Katharina Jenny, Vilijam Zdravkovic, Johannes B Erhardt, Bernhard Jost, Christian Spross
INTRODUCTION: Bone mineral density and fracture morphology are widely discussed and relevant factors when considering the different treatment options for proximal humerus fractures. It was the aim of this study to investigate the influence of local bone quality on fracture patterns of the Neer classification as well as on fracture impaction angle in these injuries. MATERIALS AND METHODS: All acute, isolated and non-pathological proximal humerus fractures admitted to our emergency department were included...
December 26, 2017: Injury
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