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https://www.readbyqxmd.com/read/28817806/specialized-mechanosensory-nociceptors-mediating-rapid-responses-to-hair-pull
#1
Nima Ghitani, Arnab Barik, Marcin Szczot, James H Thompson, Chia Li, Claire E Le Pichon, Michael J Krashes, Alexander T Chesler
The somatosensory system provides animals with the ability to detect, distinguish, and respond to diverse thermal, mechanical, and irritating stimuli. While there has been progress in defining classes of neurons underlying temperature sensation and gentle touch, less is known about the neurons specific for mechanical pain. Here, we use in vivo functional imaging to identify a class of cutaneous sensory neurons that are selectively activated by high-threshold mechanical stimulation (HTMRs). We show that their optogenetic excitation evokes rapid protective and avoidance behaviors...
August 16, 2017: Neuron
https://www.readbyqxmd.com/read/28817767/understanding-how-acoustic-vibrations-modulate-the-optical-response-of-plasmonic-metal-nanoparticles
#2
Aftab Ahmed, Matthew Pelton, Jeffrey R Guest
Measurements of acoustic vibrations in nanoparticles provide a unique opportunity to study mechanical phenomena at nanometer length scales and picosecond time scales. Vibrations in noble-metal nanoparticles have attracted particular attention, because they couple to plasmon resonances in the nanoparticles, leading to strong modulation of optical absorption and scattering. There are three mechanisms that transduce the mechanical oscillations into changes in the plasmon resonance: (1) changes in the nanoparticle geometry, (2) changes in electron density due to changes in the nanoparticle volume, and (3) changes in the interband transition energies due to compression / expansion of the nanoparticle (deformation potential)...
August 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28817730/new-approach-to-generating-insights-for-aging-research-based-on-literature-mining-and-knowledge-integration
#3
Yeondae Kwon, Yukikazu Natori, Masaru Tanokura
The proportion of the elderly population in most countries worldwide is increasing dramatically. Therefore, social interest in the fields of health, longevity, and anti-aging has been increasing as well. However, the basic research results obtained from a reductionist approach in biology and a bioinformatic approach in genome science have limited usefulness for generating insights on future health, longevity, and anti-aging-related research on a case by case basis. We propose a new approach that uses our literature mining technique and bioinformatics, which lead to a better perspective on research trends by providing an expanded knowledge base to work from...
2017: PloS One
https://www.readbyqxmd.com/read/28817724/from-the-animal-house-to-the-field-are-there-consistent-individual-differences-in-immunological-profile-in-wild-populations-of-field-voles-microtus-agrestis
#4
Elena Arriero, Klara M Wanelik, Richard J Birtles, Janette E Bradley, Joseph A Jackson, Steve Paterson, Mike Begon
Inbred mouse strains, living in simple laboratory environments far removed from nature, have been shown to vary consistently in their immune response. However, wildlife populations are typically outbreeding and face a multiplicity of challenges, parasitological and otherwise. In this study we seek evidence of consistent difference in immunological profile amongst individuals in the wild. We apply a novel method in this context, using longitudinal (repeated capture) data from natural populations of field voles, Microtus agrestis, on a range of life history and infection metrics, and on gene expression levels...
2017: PloS One
https://www.readbyqxmd.com/read/28817697/correction-field-evolved-resistance-in-corn-earworm-to-cry-proteins-expressed-by-transgenic-sweet-corn
#5
Galen P Dively, P Dilip Venugopal, Chad Finkenbinder
[This corrects the article DOI: 10.1371/journal.pone.0169115.].
2017: PloS One
https://www.readbyqxmd.com/read/28817681/pressure-in-isochoric-systems-containing-aqueous-solutions-at-subzero-centigrade-temperatures
#6
Gideon Ukpai, Gabriel Năstase, Alexandru Șerban, Boris Rubinsky
OBJECTIVE: Preservation of biological materials at subzero Centigrade temperatures, cryopreservation, is important for the field of tissue engineering and organ transplantation. Our group is studying the use of isochoric (constant volume) systems of aqueous solution for cryopreservation. Previous studies measured the pressure-temperature relations in aqueous isochoric systems in the temperature range from 0°C to - 20°C. The goal of this study is to expand the pressure-temperature measurement beyond the range reported in previous publications...
2017: PloS One
https://www.readbyqxmd.com/read/28817670/synthesis-radiosynthesis-and-in-vitro-evaluation-of-18f-bodipy-c16-triglyceride-as-a-dual-modal-imaging-agent-for-brown-adipose-tissue
#7
Andreas Paulus, Marco Maenen, Natascha Drude, Emmani B M Nascimento, Wouter D van Marken Lichtenbelt, Felix M Mottaghy, Matthias Bauwens
BACKGROUND: Brown adipose tissue research is in the focus in the field of endocrinology. We designed a dual-modal fluorescent/PET fatty acid based tracer on commercially available Bodipy-C16, which can be synthesized to its corresponding triglyceride and which combines the benefits of fluorescent and PET imaging. METHODS: Bodipy-C16 was coupled to 1,3-diolein resulting in Bodipy-triglyceride. Bodipy-C16 and Bodipy-triglyceride compounds were radiolabeled with 18F using an 18F/19F exchange reaction to yield a dual-modal imaging molecule...
2017: PloS One
https://www.readbyqxmd.com/read/28817658/hyperspectral-prediction-of-leaf-area-index-of-winter-wheat-in-irrigated-and-rainfed-fields
#8
Guangxin Li, Chao Wang, Meichen Feng, Wude Yang, Fangzhou Li, Ruiyun Feng
The growth status of winter wheat in irrigated field and rainfed field are obviously different and the field types may have an effect on the predictive accuracy of hyperspectral model. The objectives of the present study were to understand the difference of spectral sensitive wavelengths for leaf area index (LAI) in two field types and realize its hyperspectral prediction. In study, a total of 31 and 28 sample sites in irrigated fields and rainfed fields respectively were selected from Wenxi County, and the LAI and canopy spectra were also collected at the main grow stage of winter wheat...
2017: PloS One
https://www.readbyqxmd.com/read/28817629/maldi-tof-ms-identification-of-anopheles-gambiae-giles-blood-meal-crushed-on-whatman-filter-papers
#9
Sirama Niare, Lionel Almeras, Fatalmoudou Tandina, Amina Yssouf, Affane Bacar, Ali Toilibou, Ogobara Doumbo, Didier Raoult, Philippe Parola
BACKGROUND: Identification of the source of mosquito blood meals is an important component for disease control and surveillance. Recently, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) profiling has emerged as an effective tool for mosquito blood meal identification, using the abdomens of freshly engorged mosquitoes. In the field, mosquito abdomens are crushed on Whatman filter papers to determine the host feeding patterns by identifying the origin of their blood meals...
2017: PloS One
https://www.readbyqxmd.com/read/28817594/soil-pathogen-aphid-interactions-under-differences-in-soil-organic-matter-and-mineral-fertilizer
#10
Stijn van Gils, Giovanni Tamburini, Lorenzo Marini, Arjen Biere, Maaike van Agtmaal, Olaf Tyc, Martine Kos, David Kleijn, Wim H van der Putten
There is increasing evidence showing that microbes can influence plant-insect interactions. In addition, various studies have shown that aboveground pathogens can alter the interactions between plants and insects. However, little is known about the role of soil-borne pathogens in plant-insect interactions. It is also not known how environmental conditions, that steer the performance of soil-borne pathogens, might influence these microbe-plant-insect interactions. Here, we studied effects of the soil-borne pathogen Rhizoctonia solani on aphids (Sitobion avenae) using wheat (Triticum aestivum) as a host...
2017: PloS One
https://www.readbyqxmd.com/read/28817573/network-representations-of-angular-regions-for-electromagnetic-scattering
#11
Vito G Daniele, Guido Lombardi, Rodolfo S Zich
Network modeling in electromagnetics is an effective technique in treating scattering problems by canonical and complex structures. Geometries constituted of angular regions (wedges) together with planar layers can now be approached with the Generalized Wiener-Hopf Technique supported by network representation in spectral domain. Even if the network representations in spectral planes are of great importance by themselves, the aim of this paper is to present a theoretical base and a general procedure for the formulation of complex scattering problems using network representation for the Generalized Wiener Hopf Technique starting basically from the wave equation...
2017: PloS One
https://www.readbyqxmd.com/read/28817567/accounting-for-biotic-spatial-variability-in-fields-case-of-resistance-screening-against-sunflower-verticillium-wilt
#12
Hélène Missonnier, Alban Jacques, JiSu Bang, Jean Daydé, Virginie Mirleau-Thebaud
In breeding for disease resistance, the magnitude of the genetic response is difficult to appreciate because of environmental stresses that interact with the plant genotype. We discuss herein the fundamental problems in breeding for disease resistance with the aim being to better understand the interactions between plant, pathogen, and spatial patterns. The goal of this study is to fine tune breeding decisions by incorporating spatial patterns of such biotic factors into the definition of disease-occurrence probability...
2017: PloS One
https://www.readbyqxmd.com/read/28817555/notes-from-the-field-death-of-a-farm-worker-after-exposure-to-manure-gas-in-an-open-air-environment-wisconsin-august-2016
#13
John M Shutske, Rebecca A Larson, Daniel M Schaefer, Liz Y Binversie, Scott Rifleman, Cheryl Skjolaas
On August 15, 2016, at approximately 6:30 a.m., a previously healthy male employee of a Wisconsin beef farm was found dead near the edge of an outdoor 60,400 square foot (1.4 acre) manure storage basin (Figure). The basin was approximately 15 feet (4.6 meters) deep and nearly full. The victim, aged 29 years, was discovered by another worker; the coroner was notified at 6:50 a.m., and he pronounced the victim dead at the scene. Thirteen dead cattle were discovered in an adjoining pen; three others were struggling to stand and were euthanized...
August 18, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28817400/liver-xenotransplantation
#14
Madhukar S Patel, Nathan Louras, Parsia A Vagefi
PURPOSE OF REVIEW: There continues to be an inadequate organ supply and lack of effective temporary support, for patients with liver failure. The purpose of this review is to discuss recent progress in the field of orthotopic pig-to-nonhuman primate (NHP) liver xenotransplantation (LXT). RECENT FINDINGS: From 1968 to 2012, survival in pig-to-NHP LXT was limited to 9 days, initially due to hyperacute rejection which has been ameliorated through use of genetically engineered donor organs, but ultimately because of profound thrombocytopenia, thrombotic microangiopathy, and bleeding...
August 16, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28817382/quantum-mechanical-force-fields-for-condensed-phase-molecular-simulations
#15
Timothy J Giese, Darrin M York
Molecular simulations are powerful tools for providing atomic-level details into complex chemical and physical processes that occur in the condensed phase. For strongly interacting systems where quantum many-body effects are known to play an important role, density-functional methods are often used to provide the model with the potential energy used to drive dynamics. These methods, however, suffer from two major drawbacks. First, they are often too computationally intensive to practically apply to large systems over long time scales, limiting their scope of application...
August 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28817359/developing-the-storyline-for-an-advance-care-planning-video-for-surgery-patients-patient-centered-outcomes-research-engagement-from-stakeholder-summit-to-state-fair
#16
Rebecca A Aslakson, Anne L R Schuster, Thomas J Lynch, Matthew J Weiss, Lydia Gregg, Judith Miller, Sarina R Isenberg, Norah L Crossnohere, Alison M Conca-Cheng, Angelo E Volandes, Thomas J Smith, John F P Bridges
BACKGROUND: Patient-centered outcomes research (PCOR) methods and social learning theory (SLT) require intensive interaction between researchers and stakeholders. Advance care planning (ACP) is valuable before major surgery, but a systematic review found no extant perioperative ACP tools. Consequently, PCOR methods and SLT can inform the development of an ACP educational video for patients and families preparing for major surgery. OBJECTIVE: The objective is to develop and test acceptability of an ACP video storyline...
August 17, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28817304/medical-education-and-leadership-in-breastfeeding-medicine
#17
Julie Scott Taylor, Esther Bell
Physicians' experience with high quality training in breastfeeding during their medical education is historically varied. The process of becoming a board-certified physician entails more than 20 years of education, and although medical school and residency training timelines and courses are relatively standardized across the United States and even internationally, breastfeeding education varies greatly across schools and programs. The Academy of Breastfeeding Medicine (ABM) exists, in part, because historically, physicians have received too little clinical training in breastfeeding and infant nutrition...
August 17, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28817297/using-roll-up-measures-in-healthcare-quality-reports-perspectives-of-report-sponsors-and-national-alliances
#18
Jennifer L Cerully, Steven C Martino, Lise Rybowski, Melissa L Finucane, Rachel Grob, Andrew M Parker, Mark Schlesinger, Dale Shaller, Grant Martsolf
OBJECTIVES: To understand the views of prominent organizations in the field of healthcare quality on the topic of reporting roll-up measures that combine indicators of multiple, often disparate, dimensions of care to consumers. STUDY DESIGN: This study used a semi-structured, qualitative interview design. METHODS: We conducted 30- to 60-minute semi-structured telephone interviews with representatives of 10 organizations that sponsor public healthcare quality reports and 3 national alliances representing multiple stakeholder groups...
June 1, 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28817270/magnetic-field-activated-sensing-of-mrna-in-living-cells
#19
Saira F Bakshi, Nataliia Guz, Andrey Zakharchenko, Han Deng, Alexei Tumanov, Craig D Woodworth, Sergiy Minko, Dmitry M Kolpashchikov, Evgeny Katz
Detection of specific mRNA in living cells has attracted significant attention in the last decade. Probes that can be easily delivered into cells and activated at the desired time can contribute to understand-ing translation, trafficking and degradation of mRNA. Here we report a new strategy termed Magnetic Field-Activated Binary De-oxyribozyme (MaBiDZ) sensor that enables both efficient delivery and temporal control of mRNA sensing by magnetic field. MaBiDZ uses two species of magnetic beads conjugated with different com-ponents of a multicomponent deoxyribozyme (DZ) sensor...
August 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28817258/synthesis-of-complex-glycolates-by-enantioconvergent-addition-reactions
#20
Samuel L Bartlett, Jeffrey S Johnson
The unique role that stereochemistry plays in molecular recognition events continues to provide a driving force for synthesizing organic compounds in enantioenriched form. The tendency of enantioenriched organic compounds to revert to an entropically favored racemic state in the presence of viable racemization pathways (e.g., the enolization of stereogenic carbonyl derivatives) can sometimes interfere with this objective; however, beginning with Noyori's foundational disclosure of a dynamic kinetic transfer hydrogenation, the ability to channel racemic, configurationally labile starting materials through stereoconvergent reaction pathways has been recognized as a powerful strategy in asymmetric synthesis...
August 17, 2017: Accounts of Chemical Research
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