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https://www.readbyqxmd.com/read/29156758/development-of-novel-long-noncoding-rna-malat1-near-infrared-optical-probes-for-in-vivo-tumour-imaging
#1
Meng-Jie Dong, Cai-Qin Wang, Guo-Lin Wang, Yue-Hong Wang, Zhen-Feng Liu
With the advent of next-generation sequencing technology, there is rapidly increasing interest in long noncoding RNAs (lncRNAs). The objectives of this study were to develop a novel lncRNA MALAT1 near-infrared optical probe, to evaluate the characteristics of this optical imaging probe in vitro and to determine whether it can be used for imaging MALAT1 expression in malignant tumours in vivo. Conjugation of Cy5.5 to MALAT1 ASO was accomplished using standard NHS (N-hydroxysuccinimide) ester procedures, and the labelled MALAT1 ASO was purified with a Glen-Pak DNA Purification Cartridge and reversed-phase high performance liquid chromatography (HPLC)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156631/morphology-and-mechanical-properties-of-polyimide-films-the-effects-of-uv-irradiation-on-microscale-surface
#2
Changzi Qu, Junsong Hu, Xing Liu, Zheng Li, Yanhuai Ding
As an attractive dielectric material, polyimide has been widely used in the field of electronics, aerospace, and automobiles due to its useful mechanical properties and good chemical resistance. UV irradiation was considered to be the main factor related to the damage and failure of polyimide. Here the effects of UV irradiation on the surface morphology and microscale mechanical properties of polyimide films are characterized by atomic force microscopy (AFM). The surface roughness of the UV-irradiated samples developed and the mechanical properties degraded with the radiation dose increased...
November 20, 2017: Materials
https://www.readbyqxmd.com/read/29156627/multichannel-discriminative-detection-of-explosive-vapors-with-an-array-of-nanofibrous-membranes-loaded-with-quantum-dots
#3
Zhaofeng Wu, Haiming Duan, Zhijun Li, Jixi Guo, Furu Zhong, Yali Cao, Dianzeng Jia
The multichannel fluorescent sensor array based on nanofibrous membranes loaded with ZnS quantum dots (QDs) was created and demonstrated for the discriminative detection of explosives. The synergistic effect of the high surface-to-volume ratio of QDs, the good permeability of nanofibrous membranes and the differential response introduced by surface ligands was played by constructing the sensing array using nanofibrous membranes loaded with ZnS QDs featuring several surface ligands. Interestingly, although the fluorescence quenching of the nanofibrous membranes is not linearly related to the exposure time, the fingerprint of each explosive at different times is very similar in shape, and the fingerprints of the three explosives show different shapes...
November 20, 2017: Sensors
https://www.readbyqxmd.com/read/29156608/fatty-acids-antioxidants-and-physical-activity-in-brain-aging
#4
REVIEW
Hércules Rezende Freitas, Gustavo da Costa Ferreira, Isis Hara Trevenzoli, Karen de Jesus Oliveira, Ricardo Augusto de Melo Reis
Polyunsaturated fatty acids and antioxidants are important mediators in the central nervous system. Lipid derivatives may control the production of proinflammatory agents and regulate NF-κB activity, microglial activation, and fatty acid oxidation; on the other hand, antioxidants, such as glutathione and ascorbate, have been shown to signal through transmitter receptors and protect against acute and chronic oxidative stress, modulating the activity of different signaling pathways. Several authors have investigated the role of these nutrients in the brains of the young and the aged in degenerative diseases such as Alzheimer's and Parkinson's, and during brain aging due to adiposity- and physical inactivity-mediated metabolic disturbances, chronic inflammation, and oxidative stress...
November 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29156600/fabrication-of-semiconductor-zno-nanostructures-for-versatile-sers-application
#5
REVIEW
Lili Yang, Yong Yang, Yunfeng Ma, Shuai Li, Yuquan Wei, Zhengren Huang, Nguyen Viet Long
Since the initial discovery of surface-enhanced Raman scattering (SERS) in the 1970s, it has exhibited a huge potential application in many fields due to its outstanding advantages. Since the ultra-sensitive noble metallic nanostructures have increasingly exposed themselves as having some problems during application, semiconductors have been gradually exploited as one of the critical SERS substrate materials due to their distinctive advantages when compared with noble metals. ZnO is one of the most representative metallic oxide semiconductors with an abundant reserve, various and cost-effective fabrication techniques, as well as special physical and chemical properties...
November 19, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29156597/different-ways-to-apply-a-measurement-instrument-of-e-nose-type-to-evaluate-ambient-air-quality-with-respect-to-odour-nuisance-in-a-vicinity-of-municipal-processing-plants
#6
REVIEW
Bartosz Szulczyński, Tomasz Wasilewski, Wojciech Wojnowski, Tomasz Majchrzak, Tomasz Dymerski, Jacek Namieśnik, Jacek Gębicki
This review paper presents different ways to apply a measurement instrument of e-nose type to evaluate ambient air with respect to detection of the odorants characterized by unpleasant odour in a vicinity of municipal processing plants. An emphasis was put on the following applications of the electronic nose instruments: monitoring networks, remote controlled robots and drones as well as portable devices. Moreover, this paper presents commercially available sensors utilized in the electronic noses and characterized by the limit of quantification below 1 ppm v/v, which is close to the odour threshold of some odorants...
November 19, 2017: Sensors
https://www.readbyqxmd.com/read/29156588/cytotoxicity-of-poly-alkyl-cyanoacrylate-nanoparticles
#7
Einar Sulheim, Tore-Geir Iversen, Vu To Nakstad, Geir Klinkenberg, Håvard Sletta, Ruth Schmid, Anne Rein Hatletveit, Ane Marit Wågbø, Anders Sundan, Tore Skotland, Kirsten Sandvig, Ýrr Mørch
Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated in several cell lines with different methods and on multiple nanoparticle batches. Here we report the toxicity of poly(alkyl cyanoacrylate) nanoparticles in 12 different cell lines after synthesizing and analyzing 19 different nanoparticle batches and report that large variations were obtained when using different cell lines or various toxicity assays...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156577/magnetic-flux-distribution-of-linear-machines-with-novel-three-dimensional-hybrid-magnet-arrays
#8
Nan Yao, Liang Yan, Tianyi Wang, Shaoping Wang
The objective of this paper is to propose a novel tubular linear machine with hybrid permanent magnet arrays and multiple movers, which could be employed for either actuation or sensing technology. The hybrid magnet array produces flux distribution on both sides of windings, and thus helps to increase the signal strength in the windings. The multiple movers are important for airspace technology, because they can improve the system's redundancy and reliability. The proposed design concept is presented, and the governing equations are obtained based on source free property and Maxwell equations...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29156575/synthesis-of-oxadiazole-thiadiazole-hybrids-and-their-anticandidal-activity
#9
Serkan Levent, Betül Kaya Çavuşoğlu, Begüm Nurpelin Sağlık, Derya Osmaniye, Ulviye Acar Çevik, Özlem Atlı, Yusuf Özkay, Zafer Asım Kaplancıklı
In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel oxadiazole-thiadiazole hybrid compounds (6a-6s) and evaluate their antifungal activity. The structures of synthesized compounds were elucidated by various methods including FT-IR, ¹H-NMR, (13)C-NMR and HR-MS spectral data. Compounds were tested against four Candida species by broth microdilution assay...
November 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29156566/cgas-sting-pathway-in-cancer-jekyll-and-hyde-story-of-cancer-immune-response
#10
REVIEW
Debojit Bose
The last two decades have witnessed enormous growth in the field of cancer immunity. Mechanistic insights of cancer immunoediting have not only enhanced our understanding but also paved the way to target and/or harness the innate immune system to combat cancer, called cancer immunotherapy. Cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon genes(STING) pathway has recently emerged as nodal player in cancer immunity and is currently being explored as potential therapeutic target. Although therapeutic activation of this pathway has shown promising anti-tumor effects in vivo, evidence also indicates the role of this pathway in inflammation mediated carcinogenesis...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156564/wireless-monitoring-of-induction-machine-rotor-physical-variables
#11
Jefferson Doolan Fernandes, Francisco Elvis Carvalho Souza, Glauco George Cipriano Maniçoba, Andrés Ortiz Salazar, José Alvaro de Paiva
With the widespread use of electric machines, there is a growing need to extract information from the machines to improve their control systems and maintenance management. The present work shows the development of an embedded system to perform the monitoring of the rotor physical variables of a squirrel cage induction motor. The system is comprised of: a circuit to acquire desirable rotor variable(s) and value(s) that send it to the computer; a rectifier and power storage circuit that converts an alternating current in a continuous current but also stores energy for a certain amount of time to wait for the motor's shutdown; and a magnetic generator that harvests energy from the rotating field to power the circuits mentioned above...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29156546/systematic-review-of-epigenetic-effects-of-pharmacological-agents-for-bipolar-disorders
#12
REVIEW
Laura E Lockwood, Nagy A Youssef
Epigenetic effects of medications are an evolving field of medicine, and can change the landscape of drug development. The aim of this paper is to systematically review the literature of the relationship between common medications used for treatment of bipolar disorders and epigenetic modifications. MedLine/PubMed searches were performed based on pre-specified inclusion criteria from inception to November 2017. Six animal and human studies met the inclusion criteria. These studies examined the epigenetic changes in the main classes of medications that are used in bipolar disorders, namely mood stabilizers and antipsychotics...
November 18, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29156527/synthesis-and-characterization-of-copper-nanoparticles-stabilized-with-quisqualis-indica-extract-evaluation-of-its-cytotoxicity-and-apoptosis-in-b16f10-melanoma-cells
#13
Ria Mukhopadhyay, Julekha Kazi, Mita Chatterjee Debnath
Green synthesis of metallic nanoparticles is a cost-effective environment-friendly technique and Quisqualis indica has ethnomedicinal values. With this background in this study, the floral extract of Q. indica was used to fabricate copper nanoparticles (QCuNPs) from copper acetate. Biophysical analysis revealed the formation of spherical, monodisperse, crystalline QCuNPs. Significant cytotoxic potentials of the nanoformulation were determined by MTT and lactate dehydrogenase (LDH) assay on B16F10 melanoma cells...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156485/-cervical-plexus-blocks
#14
Ronald Seidel
Blockades of the cervical plexus are established anesthesia procedures, not only in the context of operative carotid revascularizations. Recent investigations define inner sonoanatomic landmarks as well as the importance of brain nerves for innervation in the neck region. The present practice-oriented article discusses current study results, alternative techniques (ultrasound- versus landmark-guided) and fields of application (carotid desobliteration, surgery of the shoulder, ear and infraclavicular region)...
November 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29156465/-pseudophacic-additive-lenses
#15
Fritz H Hengerer, Ina Conrad-Hengerer
Implantation of artificial intraocular lenses (IOL) after cataract removal today represents the standard of care in the field of anterior segment surgery. In refractive lens exchange cases the natural lens is replaced by an IOL to correct different types of refractive situations. In the majority of the operations the refractive result is satisfying with only few deviations from target refraction.But daily practice reveals some outliers from the intended corrections with the need for further refractive enhancements, respectively...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29156448/-de-hydratases-recent-developments-and-future-perspectives
#16
REVIEW
Rebecca M Demming, Max-Philipp Fischer, Jens Schmid, Bernhard Hauer
Hydratases have gained attention as alternative to chemical catalysts for their ability to add and eliminate water with high regio-selectivity, stereo-selectivity and enantio-selectivity. Recently, especially cofactor-independent hydratases came into research focus as they are of particular interest for industrial application. The investigation of the substrate scope as well as mutagenesis studies combined with high-resolution crystal structures and bioinformatic methods shed light on this promising enzyme class...
November 17, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29156447/pd-1-blockade-in-advanced-nsclc-a-focus-on-pembrolizumab
#17
REVIEW
Solange Peters, Keith M Kerr, Rolf Stahel
Non-small cell lung cancer (NSCLC) is one of the most prevalent cancers and is responsible for a large proportion of all cancer-related deaths. Current treatment options are inadequate, reflecting a substantial unmet clinical need. Increasing knowledge regarding the mechanisms and genetic aberrations underlying tumor development and growth has heralded a new era of therapy in oncology, moving away from indiscriminate cytotoxic chemotherapy toward more finely focused, targeted medicine. The development of small-molecule drugs and monoclonal antibodies directed toward specific components of dysfunctional molecular or immune pathways, and mutated genes specific to particular cancer types, is leading the field to more personalized and less toxic treatment options, many of which have demonstrated greater efficacy and survival benefits than their chemotherapeutic counterparts...
October 23, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29156397/composition-determination-of-multinary-iii-v-semiconductors-via-stem-haadf-multislice-simulations
#18
Lennart Duschek, Andreas Beyer, Jan Oliver Oelerich, Kerstin Volz
Knowledge of the microscopic elemental composition of multinary III/V semiconductor materials is crucial to the development of functionalized opto-electronic devices. Well-proven composition analysis methods, such as high resolution X-ray diffraction (HRXRD), fail to determine the elemental composition when more than three atomic species are involved. In this work we propose a procedure for the composition analysis of multinary III/V semiconductors at atomic resolution using high angle annular dark field (HAADF) scanning transmission electron microscopy (STEM) image simulations...
November 9, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29156394/assessment-of-sampling-strategies-for-estimation-of-site-mean-concentrations-of-stormwater-pollutants
#19
David T McCarthy, Kefeng Zhang, Camilla Westerlund, Maria Viklander, Jean-Luc Bertrand-Krajewski, Tim D Fletcher, Ana Deletic
The estimation of stormwater pollutant concentrations is a primary requirement of integrated urban water management. In order to determine effective sampling strategies for estimating pollutant concentrations, data from extensive field measurements at seven different catchments was used. At all sites, 1-min resolution continuous flow measurements, as well as flow-weighted samples, were taken and analysed for total suspend solids (TSS), total nitrogen (TN) and Escherichia coli (E. coli). For each of these parameters, the data was used to calculate the Event Mean Concentrations (EMCs) for each event...
October 23, 2017: Water Research
https://www.readbyqxmd.com/read/29156316/neutral-dipole-dipole-dimers-a-new-field-in-science
#20
Edward M Kosower, Galina Borz
Dimer formation with dipole neutralization produces species such as low polarity water (LPW) compatible with hydrophobic surfaces (Phys. Chem. Chem. Phys. 2015, 17, 24895-24900) Dimerization and dipole neutralization occurs for N-methylacetamide on polyethylene, a behavior drastically different from its contortions in acetonitrile on AgBr:AgCl planar crystals (AgX) (ChemPhysChem 2014, 15, 3598-3607). The weak infrared absorption of the amide dimer on polyethylene is shown experimentally. Dimerization of palmitic acid is shown along with some of the many ramifications for intracellular systems...
November 11, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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