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(Hip OR Femur) AND fracture

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https://www.readbyqxmd.com/read/29679025/combining-electrical-stimulation-and-tissue-engineering-to-treat-large-bone-defects-in-a-rat-model
#1
Liudmila Leppik, Han Zhihua, Sahba Mobini, Vishnu Thottakkattumana Parameswaran, Maria Eischen-Loges, Andrei Slavici, Judith Helbing, Lukas Pindur, Karla M C Oliveira, Mit B Bhavsar, Lukasz Hudak, Dirk Henrich, John H Barker
Bone Tissue engineering (BTE) has recently been introduced as an alternative to conventional treatments for large non-healing bone defects. BTE approaches mimic autologous bone grafts, by combining cells, scaffold, and growth factors, and have the added benefit of being able to manipulate these constituents to optimize healing. Electrical stimulation (ES) has long been used to successfully treat non-healing fractures and has recently been shown to stimulate bone cells to migrate, proliferate, align, differentiate, and adhere to bio compatible scaffolds, all cell behaviors that could improve BTE treatment outcomes...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678580/microrna-185-inhibits-the-growth-and-proliferation-of-osteoblasts-in-fracture-healing-by-targeting-pth-gene-through-down-regulating-wnt-%C3%AE-catenin-axis-in-an-animal-experiment
#2
Chang-Jiang Yao, Yang Lv, Cheng-Jun Zhang, Jia-Xin Jin, Li-Hu Xu, Jin Jiang, Bin Geng, Hong Li, Ya-Yi Xia, Meng Wu
Fracture healing is a repair process of a mechanical discontinuity loss of force transmission, and pathological mobility of bone. Increasing evidence suggests that microRNA (miRNA) could regulate chondrocyte, osteoblast, and osteoclast differentiation and function, indicating miRNA as key regulators of bone formation, resorption, remodeling, and repair. Hence, during this study, we established a right femur fracture mouse model to explore the effect microRNA-185 (miR-185) has on osteoblasts in mice during fracture healing and its underlying mechanism...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678393/positive-correlations-between-free-vitamin-d-and-bone-variables-in-a-group-of-young-lebanese-women
#3
Abir Alwan, Maroun Rizkallah, Ghassan Maalouf, Joseph Matta, Fabienne Frenn, Angélique Barakat, Falah Bachour, Amer Sebaaly, Abdel-Jalil Berro, Nathalie Al Rassy, Mirza Howayek, Hassane Zouhal, Rawad El Hage
Optimizing bone mass in adulthood is of great importance to prevent the occurrence of osteoporosis in later age. Vitamin D is an essential component of bone health. Low-serum vitamin D is associated with low bone mineral density (BMD), which is an important predictor of fracture risk. However, most cells, apart from renal tubular cells, are exposed to free rather than to total 25-hydroxyvitamin D. Whether free vitamin D would be a better marker than total vitamin D is still under debate. The aim of the present study was to explore the relationships between serum total vitamin D, vitamin D-binding protein (BP), free vitamin D, and bone parameters in a group of young Lebanese women...
March 26, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29677309/vitamin-d-calcium-or-combined-supplementation-for-the-primary-prevention-of-fractures-in-community-dwelling-adults-us-preventive-services-task-force-recommendation-statement
#4
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Martha Kubik, Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Because of the aging population, osteoporotic fractures are an increasingly important cause of morbidity and mortality in the United States. Approximately 2 million osteoporotic fractures occurred in the United States in 2005, and annual incidence is projected to increase to more than 3 million fractures by 2025. Within 1 year of experiencing a hip fracture, many patients are unable to walk independently, more than half require assistance with activities of daily living, and 20% to 30% of patients will die...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29677308/vitamin-d-calcium-or-combined-supplementation-for-the-primary-prevention-of-fractures-in-community-dwelling-adults-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#5
Leila C Kahwati, Rachel Palmieri Weber, Huiling Pan, Margaret Gourlay, Erin LeBlanc, Manny Coker-Schwimmer, Meera Viswanathan
Importance: Osteoporotic fractures result in significant morbidity and mortality. Objective: To update the evidence for benefits and harms of vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults to inform the US Preventive Services Task Force. Data Sources: PubMed, EMBASE, Cochrane Library, and trial registries through March 21, 2017; references; and experts. Surveillance continued through February 28, 2018...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29677091/factors-associated-with-revision-surgery-after-internal-fixation-of-hip-fractures
#6
Sheila Sprague, Emil H Schemitsch, Marc Swiontkowski, Gregory J Della Rocca, Kyle J Jeray, Susan Liew, Gerard P Slobogean, Sofia Bzovsky, Diane Heels-Ansdell, Qi Zhou, Mohit Bhandari
BACKGROUND: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery...
May 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29676780/retrospective-evaluation-of-a-restrictive-transfusion-strategy-in-older-adults-with-hip-fracture
#7
Lorene Zerah, Lucile Dourthe, Judith Cohen-Bittan, Marc Verny, Mathieu Raux, Anthony Mézière, Frédéric Khiami, Cendrine Tourette, Christian Neri, Yannick Le Manach, Bruno Riou, Hélène Vallet, Jacques Boddaert
OBJECTIVES: To compare the association between a restrictive transfusion strategy and cardiovascular complications during hospitalization for hip fracture with the association between a liberal transfusion strategy and cardiovascular complications, accounting for all transfusions from the emergency department to postacute rehabilitation settings. DESIGN: Retrospective study. SETTING: Perioperative geriatric care unit. PARTICIPANTS: All individuals aged 70 and older admitted to the emergency department for hip fracture and hospitalized in our perioperative geriatric care unit (N=667; n=193 in the liberal transfusion group, n=474 in the restrictive transfusion group) from July 2009 to April 2016...
April 20, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29675770/sports-participation-and-fracture-in-older-australian-men
#8
Kara L Holloway-Kew, David J Moloney, Gosia Bucki-Smith, Natalie K Hyde, Sharon L Brennan-Olsen, Elizabeth N Timney, Amelia G Dobbins, Julie A Pasco
Older men who participated in a sporting activity were less likely to sustain any fracture or major osteoporotic fracture over a 6-year follow-up period. PURPOSE: Regular weight-bearing physical activity can reduce fracture risk through an increase in bone strength, as well as reducing falls risk by improving muscle strength and balance. In this study, we aimed to determine whether a specific type of physical activity, sports participation, reduces fracture risk in older Australian men...
April 19, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29675745/a-proposal-for-an-atypical-femur-fracture-treatment-and-prevention-clinical-practice-guideline
#9
REVIEW
R Dell, D Greene
The prevention as well as the treatment of atypical femur fractures (AFFs) remains controversial but there have been many clinical recommendations suggested. We have summarized these recommendations as well as expanded upon them in this paper. INTRODUCTION: The purpose of the paper was to develop a clinical practice guideline that both treats AFF and decreases the risk of AFF in patients requiring antiresorptive medications. Examples of these medications include bisphosphonates and denosumab for the treatment of osteoporosis...
April 19, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29675629/-geriatric-trauma-center-dgu%C3%A2-evaluation-of-clinical-and-economic-parameters-a-pilot-study-in-a-german-university-hospital
#10
M Knobe, B Böttcher, M Coburn, T Friess, L C Bollheimer, H J Heppner, C J Werner, J-P Bach, M Wollgarten, S Poßelt, C Bliemel, B Bücking
BACKGROUND: Previous studies on orthogeriatric models of care suggest that there is substantial variability in how geriatric care is integrated in the patient management and the necessary intensity of geriatric involvement is questionable. OBJECTIVE: The aim of the current prospective cohort study was the clinical and economic evaluation of fragility fracture treatment pathways before and after the implementation of a geriatric trauma center in conformity with the guidelines of the German Trauma Society (DGU)...
April 19, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29674847/good-function-and-high-patient-satisfaction-at-mean-2-8-years-after-dual-mobility-tha-following-femoral-neck-fracture-a-cross-sectional-study-of-124-patients
#11
Steffan Tabori-Jensen, Torben B Hansen, Søren Bøvling, Peter Aalund, Morten Homilius, Maiken Stilling
Aims: Our aim was to investigate function, health status and satisfaction in patients treated with primary dual mobility (DM) total hip arthroplasty (THA) after displaced femoral neck fracture (FNF). Patients and methods: From 2005-2011, 414 consecutive FNF patients received Saturne DM THA. At a minimum of 1-year follow-up, 124 (95 women) were evaluated with Oxford Hip Score (OHS), Harris Hip Score (HHS), health-related quality of life (HRQoL) measure (EQ-5D) and two functional tests: Timed Up and Go (TUG) and Sit to Stand 10 times (STS)...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29674111/pre-operative-factors-associated-with-increased-mortality-in-elderly-patients-with-a-hip-fracture-a-cohort-study-in-a-developing-country
#12
Kristian A Espinosa, Amparo Gómez Gélvez, Liliana P Torres, María Fernanda García, Omar R Peña
BACKGROUND: Hip fractures are a public health problem worldwide, and several factors are involved with post-operative mortality. The aim of this study was to identify the pre-operative factors associated with increased mortality in elderly patients with hip fractures in a developing country during the first post-operative year. METHODS: An ambidirectional cohort study was conducted with patients ≥ 65 years of age who underwent hip surgery due to a hip fracture caused by a fall from a standing position...
April 13, 2018: Injury
https://www.readbyqxmd.com/read/29673756/hip-fracture-risk-in-patients-with-alcoholic-cirrhosis-a-population-based-study-using-english-and-danish-data
#13
H Otete, T Deleuran, K M Fleming, T R Card, G P Aithal, P Jepsen, J West
BACKGROUND & AIMS: Cirrhosis is a risk factor for osteoporosis and fractures. However, little is known of the actual risk of hip fractures in patients with alcoholic cirrhosis. Using linked primary and secondary care data from the English and Danish nationwide registries, we quantified the hip fracture risk in two national cohorts of patients with alcoholic cirrhosis. METHODS: We followed 3,706 English and 17,779 Danish patients with a diagnosis of alcoholic cirrhosis, and we identified matched controls from the general populations...
April 16, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29673552/fracture-of-cobalt-chrome-fully-coat-beaded-femoral-revision-long-stem-a-clinical-outcomes-study
#14
Chih-Hsiang Chang, Po-Chun Lin, Cheng-Min Shih, Chun-Chieh Chen, Pang-Hsin Hsieh, Hsin-Nung Shih
BACKGROUND: Femoral bone loss during revision total hip arthroplasty poses a challenging problem. Bypass fixation over the diaphysis has achieved clinical success in cases of proximal femoral bone loss. Fracture of cementless, fully bead-coated femoral stem is an uncommon complication. The purpose of this study is to analyze the patients with and without fracture stem and find out the possible risk factors. METHODS: From 2006 to 2012, a total of 251 revision long stems (Zimmer, Warsaw, IN) were implanted...
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29673377/total-hip-arthroplasty-to-treat-acetabular-protrusions-secondary-to-rheumatoid-arthritis
#15
Ping Zhen, Xusheng Li, Shenghu Zhou, Hao Lu, Hui Chen, Jun Liu
BACKGROUND: The treatment of acetabular protrusions during total hip arthroplasty of patients with rheumatoid arthritis is difficult. A lack of bone stock, deficient medial cup support, and medialization of the joint center in those with protrusio acetabuli must be addressed during acetabular reconstruction. The purpose of this study was to assess the short-term clinical results of total hip arthroplasty in patients with severe acetabular protrusions secondary to rheumatoid arthritis...
April 19, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29672532/the-effects-of-increasing-longevity-and-changing-incidence-on-lifetime-risk-differentials-a-decomposition-approach
#16
Marcus Ebeling, Karin Modig, Anders Ahlbom, Roland Rau
Increasing longevity can distort time trends in summary measures of health and mortality, such as the lifetime risk of getting diseased. If not observing a cohort, this lifetime risk is calculated with cross-sectional data on age-specific incidence and survival. In those instances, incidence and survival may work in opposite directions resulting in lifetime risk estimates where, reductions in incidence might be offset by a simultaneous longevity increase. The proposed method decomposes the difference between two lifetime risks into contributions of changing incidence and changing survival...
2018: PloS One
https://www.readbyqxmd.com/read/29672437/risk-of-fractures-in-inflammatory-bowel-diseases-a-systematic-review-and-meta-analysis
#17
Yuga Komaki, Fukiko Komaki, Dejan Micic, Akio Ido, Atsushi Sakuraba
BACKGROUND: Studies assessing the risk of fractures in inflammatory bowel diseases (IBD) have shown controversial results. GOALS: We performed a systematic review and meta-analysis to assess the risk of fractures in IBD. STUDY: Electronic databases were searched for cohort studies assessing the risk of fractures in IBD. The outcomes were the risk of overall fractures and at specific sites, and the association between the risk of fractures and the proportion of patients with corticosteroid use or osteoporosis...
April 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29672393/prospective-prognostic-cohort-study-of-pressure-injuries-in-older-adult-patients-with-hip-fractures
#18
Cristiana Forni, Fabio D'Alessandro, Rossana Genco, Sandra Mini, Teresa Notarnicola, Arianna Vitulli, Daniela Capezzali, Mattia Morri
OBJECTIVE: The aim of this study was to assess the rate of pressure injury and real predictors thereof in the older adult population with hip fractures in an orthopedic hospital. METHODS: In this prospective prognostic cohort study, all patients admitted with fragility hip fractures were monitored over a 12-month period. On a daily basis, ward nurses and physiotherapists assessed the condition of the patients' skin and collected data about all the predictors connected to their healthcare and hospital organization until the patients were discharged from hospital or until the onset of pressure injury...
May 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29671044/comparison-of-femur-stiffness-measured-from-dxa-and-qct-for-assessment-of-hip-fracture-risk
#19
Yunhua Luo, Huijuan Yang
Femur stiffness, for example axial and bending stiffness, integrates both geometric and material information of the bone, and thus can be an effective indicator of bone strength and hip fracture risk. Femur stiffness is ideally measured from quantitative computed tomography (QCT), but QCT is not recommended for routine clinical use due to the public concern about exposure to high-dosage radiation. Dual energy X-ray absorptiometry (DXA) is currently the primary imaging modality in clinic. However, DXA is two-dimensional and it is not clear whether DXA-estimated stiffness has adequate accuracy to replace its QCT counterpart for clinical application...
April 18, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29670988/reducing-complications-and-overall-healthcare-costs-of-hip-fracture-management-a-retrospective-study-on-the-application-of-a-diagnostic-therapeutic-pathway-in-the-cosenza-general-hospital
#20
M Loizzo, F Gallo, D Caruso
BACKGROUND: Diagnostic Therapeutic Pathways (DTPs) are multidisciplinary plans designed by each healthcare organization for a specific category of patients to reduce the variability of professional behaviors and to ensure greater safety and better overall healthcare outcomes. Hip fractures are a frequent traumatic injury, particularly in the elderly, and DTPs recommend early surgical intervention, often not done due to organizational challenges and bureaucracy. Medical conditions suggesting a delay are not frequent, however long waiting times not only increase the risk of complications and mortality, but also increase the number of diagnostic test and physician consultations...
May 2018: Annali di Igiene: Medicina Preventiva e di Comunità
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