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https://www.readbyqxmd.com/read/29471541/the-caucasian-nasal-septum-an-in-vivo-computed-tomography-study
#1
Charles Daultrey, John Hardman, Shahram Anari
Background: The nasal septum is composed of cartilaginous and bony components and an understanding of each component volume is essential in both functional and cosmetic surgery. Objectives: We sought to radiographically measure septal dimensions on cross sectional computer tomography (CT) images, establishing average parameters for normal anatomy among a single, Caucasian population group. Methods: One hundred and fifty consecutive sinus CT scan images were examined and 100 cases with appropriate sagittal views were included in the study...
February 19, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29470979/transcriptional-information-revealed-differentially-expressed-circular-rnas-in-facet-joint-osteoarthritis
#2
Chen Chu, Wu Chunshuai, Chen Jiajia, Zhang Jinlong, Xue Pengfei, Jiang Jiawei, Cui Zhiming
Circular RNAs are newly identified RNAs that regulate gene expression and execute various biological activities. Facet joint osteoarthritis (FJOA) is a severe facet joint cartilage degeneration disease that induces chronic low back pain to a larger population. The molecular mechanisms of FJOA, especially the presence and changes of circular RNAs in FJOA have not been investigated. In the current study, we analyzed RNA deep sequencing outcomes from healthy control group and FJOA group, identified and annotated circular RNAs, and determined the expressions of circular RNAs...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29470561/safety-and-efficacy-of-cosmetic-augmentation-of-the-nasal-tip-and-nasal-dorsum-with-expanded-polytetrafluoroethylene-a-randomized-clinical-trial
#3
Yifei Gu, Wenxin Yu, Yunbo Jin, Hui Chen, Gang Ma, Shih-Jen Chang, Xiaoxi Lin
Importance: Expanded polytetrafluoroethylene (ePTFE) is a widely used alloplast, but studies of augmentation of the nasal tip and nasal dorsum with ePTFE are lacking. Objective: To investigate whether attaching the conchal cartilage as shield grafts at the distal end of the graft can prevent extrusion and whether the use of ePTFE in the nasal tip can achieve a stable aesthetic outcome. Design, Setting, and Participants: A randomized clinical trial was performed from April 1, 2006, to October 31, 2008...
February 22, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29470431/articular-cartilage-aging-potential-regenerative-capacities-of-cell-manipulation-and-stem-cell-therapy
#4
REVIEW
Magdalena Krajewska-Włodarczyk, Agnieszka Owczarczyk-Saczonek, Waldemar Placek, Adam Osowski, Joanna Wojtkiewicz
Changes in articular cartilage during the aging process are a stage of natural changes in the human body. Old age is the major risk factor for osteoarthritis but the disease does not have to be an inevitable consequence of aging. Chondrocytes are particularly prone to developing age-related changes. Changes in articular cartilage that take place in the course of aging include the acquisition of the senescence-associated secretory phenotype by chondrocytes, a decrease in the sensitivity of chondrocytes to growth factors, a destructive effect of chronic production of reactive oxygen species and the accumulation of the glycation end products...
February 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29470279/acute-serum-cartilage-biomarker-response-following-walking-and-drop-landing
#5
Matthew S Harkey, J Troy Blackburn, Anthony C Hackney, Michael D Lewek, Randy J Schmitz, Brian Pietrosimone
INTRODUCTION: An in depth understanding of the healthy cartilage response to activities of daily living is needed to better understand the complex relationship between cartilage health and loading. The purpose was to assess the role of loading on the acute serum cartilage oligomeric matrix protein (COMP) response in recreationally active individuals. METHODS: 40 individuals without previous lower extremity injury participated in this repeated measures study in which each participant completed all conditions during independent data collection sessions separated by at least one week...
February 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29470158/the-clinical-significance-of-osteophytes-in-compartments-of-the-knee-joint-with-normal-articular-cartilage
#6
B Keegan Markhardt, Geng Li, Richard Kijowski
OBJECTIVE: The purpose of this study is to determine whether marginal osteophytes in compartments with normal cartilage would be more frequently observed in knees with cartilage lesions and osteophytes in other compartments. MATERIALS AND METHODS: This retrospective study reviewed 500 consecutive knee MRI examinations performed within 6 months of arthroscopic knee surgery conducted for 497 patients with symptoms (289 male patients and 208 female patients; age range, 17-74 years; median age, 43 years)...
February 22, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29469223/mitoprotective-therapy-preserves-chondrocyte-viability-and-prevents-cartilage-degeneration-in-an-ex-vivo-model-of-posttraumatic-osteoarthritis
#7
Michelle L Delco, Edward D Bonnevie, Hazel S Szeto, Lawrence J Bonassar, Lisa A Fortier
No disease-modifying osteoarthritis (OA) drugs are available to prevent posttraumatic osteoarthritis (PTOA). Mitochondria (MT) mediate the pathogenesis of many degenerative diseases, and recent evidence indicates that MT dysfunction is a peracute (within minutes to hours) response of cartilage to mechanical injury. The goal of this study was to investigate cardiolipin-targeted mitoprotection as a new strategy to prevent chondrocyte death and cartilage degeneration after injury. Cartilage was harvested from bovine knee joints and subjected to a single, rapid impact injury (24...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29469172/segmentation-of-hip-cartilage-in-compositional-magnetic-resonance-imaging-a-fast-accurate-reproducible-and-clinically-viable-semi-automated-methodology
#8
Dr Scott Fernquest, Dr Daniel Park, Dr Marija Marcan, Mr Antony Palmer, Dr Irina Voiculescu, Prof Sion Glyn-Jones
Manual segmentation is a significant obstacle in the analysis of compositional MRI for clinical decision-making and research. Our aim was to produce a fast, accurate, reproducible, and clinically viable semi-automated method for segmentation of hip MRI. We produced a semi-automated segmentation method for cartilage segmentation of hip MRI sequences consisting of a two step process: (1) fully automated hierarchical partitioning of the data volume generated using a bespoke segmentation approach applied recursively, followed by (2) user selection of the regions of interest using a region editor...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29469166/spheroid-based-3d-cell-cultures-identify-salinomycin-as-a-promising-drug-for-the-treatment-of-chondrosarcoma
#9
Francesca Perut, Francesca Vittoria Sbrana, Sofia Avnet, Angelo De Milito, Nicola Baldini
Chondrosarcoma (CS) is a cartilage malignancy of adulthood that is treated by surgery alone, since chemotherapy is considered ineffective. Unfortunately, a large proportion of patients with CS develop lung metastases, and several die of the disease. In this study, we compared 3D-spheroid cultures and conventional cell monolayer models in order to identify the best way to select anticancer agents that could be effective for the systemic control of CS. Using SW1353 cells, we developed a three-dimensional (3D) in vitro culture model to mimic in vivo features of CS microenvironment and evaluated the efficacy of different drugs to modulate CS cell proliferation and survival in 2D vs...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29468514/-cartilage-repair-therapies-of-the-talus
#10
REVIEW
Oliver Gottschalk, Sebastian Altenberger, Markus Walther
No abstract text is available yet for this article.
September 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29468267/a-congenital-accessory-skin-appendage-of-the-nasal-columella-and-nostril-sill-a-rare-anatomical-variation
#11
Yung Ki Lee, Young Hun Chung, Jin Sik Burm
PURPOSE: An accessory skin appendage of the nasal columella and nostril sill is an extremely rare congenital anatomical malformation; only a single case has been reported in the literature. However, no pathophysiology has been proposed. The purpose of this study is to present a review of the anatomical distribution of accessory skin appendages and provide a comprehensive review of their pathophysiology based on embryological development. METHODS: We present four cases of a protruding skin appendage of the nasal columella or nostril sill...
February 22, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29468100/bursal-synovial-chondromatosis-secondary-to-underlying-osteochondroma-in-a-child
#12
Kumail Khandwala, Adeel A Waheed, Muhammad I Alvi, Waseem A Mirza, Masood Umer, Eraj Khurshid
Osteochondroma and synovial chondromatosis are frequently reported benign bony and cartilaginous lesions. Osteochondroma is distinguished by a cartilage-capped bony exostosis on the exterior surface of the bone, whereas synovial chondromatosis is secondary to metaplasia and is characterized by multiple cartilaginous loose bodies within the synovium. We present an atypical case of synovial chondromatosis developing in a bursa sec-ondary to an underlying osteochondroma of the proximal medial tibia in a child...
December 14, 2017: Curēus
https://www.readbyqxmd.com/read/29467509/magnesium-enhances-the-chondrogenic-differentiation-of-mesenchymal-stem-cells-by-inhibiting-activated-macrophage-induced-inflammation
#13
Tu Hu, Haitao Xu, Chongyang Wang, Hui Qin, Zhiquan An
Magnesium deficiency increases the generation of pro-inflammatory cytokines, which is consistently accompanied by the sensitization of cells such as neutrophils, macrophages and endothelial cells. We investigated the potential of magnesium to regulate macrophage polarization and macrophage-induced inflammation with or without lipopolysaccharide (LPS) and interferon-γ (IFN-γ) activation and further elucidated whether these effects impact the inhibitory functions of activated macrophage-induced inflammation on cartilage regeneration...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467016/advancing-osteochondral-tissue-engineering-bone-morphogenetic-protein-transforming-growth-factor-and-fibroblast-growth-factor-signaling-drive-ordered-differentiation-of-periosteal-cells-resulting-in-stable-cartilage-and-bone-formation-in-vivo
#14
L F Mendes, H Katagiri, W L Tam, Y C Chai, L Geris, S J Roberts, F P Luyten
BACKGROUND: Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects. In this study, self-assembling tissue intermediates (TIs) derived from human periosteum-derived stem/progenitor cells (hPDCs) were generated and validated for stable cartilage formation in vivo using two different animal models. METHODS: hPDCs were aggregated and cultured in the presence of a novel growth factor (GF) cocktail comprising of transforming growth factor (TGF)-β1, bone morphogenetic protein (BMP)2, growth differentiation factor (GDF)5, BMP6, and fibroblast growth factor (FGF)2...
February 21, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29466929/histological-scoring-method-to-assess-bone-healing-in-critical-size-bone-defect-models
#15
Zhihua Han, Mit Bhavsar, Liudmila Leppik, Karla M C Oliveira, John H Barker
Large bone defects are a major problem in trauma and orthopedic surgery. Tissue engineering based treatments have emerged as promising alternatives of traditional bone grafting techniques. Critical size bone defect animal models had been developed and widely used to evaluate and compare therapeutic effectiveness in bone tissue engineering treatments. To measure healing in a given defect, after treatment histological assessment methods are commonly used. These histological methods are typically either qualitative and/or measure the amount of newly formed bone...
February 21, 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29466042/use-of-a-3-telsa-magnet-to-perform-delayed-gadolinium-enhanced-magnetic-resonance-imaging-of-the-distal-interphalangeal-joint-of-horses-with-and-without-naturally-occurring-osteoarthritis
#16
Andrea S Bischofberger, Anton E Fürst, Paul R Torgerson, Ann Carstens, Monika Hilbe, Patrick Kircher
OBJECTIVE To characterize delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) features of healthy hyaline cartilage of the distal interphalangeal joint (DIPJ) of horses, to determine whether dGEMRIC can be used to differentiate various stages of naturally occurring osteoarthritis of the DIPJ, and to correlate relaxation times determined by dGEMRIC with the glycosaminoglycan concentration, water content, and macroscopic and histologic findings of hyaline cartilage of DIPJs with and without osteoarthritis...
March 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29465334/association-of-mucoid-degeneration-of-the-anterior-cruciate-ligament-at-mr-imaging-with-medial-tibiofemoral-osteoarthritis-progression-at-radiography-data-from-the-osteoarthritis-initiative
#17
Robert M Kwee, Nima Hafezi-Nejad, Frank W Roemer, Bashir A Zikria, David J Hunter, Ali Guermazi, Shadpour Demehri
Purpose To determine whether anterior cruciate ligament (ACL) mucoid degeneration in participants with or at risk for osteoarthritis is associated with longitudinal risk of radiographic progression of medial tibiofemoral compartment joint space loss (JSL). Materials and Methods Baseline demographic, clinical, radiographic, and Magnetic Resonance (MR) Imaging Osteoarthritis Knee Score (MOAKS) data were evaluated in 600 participants from the Osteoarthritis Initiative database. Two blinded musculoskeletal radiologists independently evaluated baseline MR images for ACL mucoid degeneration...
February 21, 2018: Radiology
https://www.readbyqxmd.com/read/29464784/total-nasal-reconstruction-with-3d-custom-made-porous-titanium-prosthesis-and-free-thoracodorsal-artery-perforator-flap-a-case-report
#18
Quentin Qassemyar, Nathaniel Assouly, Yoni Madar, Stéphane Temam, Frédéric Kolb
Total nasal reconstruction is a challenging surgical procedure which usually involves a free flap, forehead flap, and cartilage grafts. In certain failure situations where patients do not accept the idea of anaplastology, possibilities become very limited. We report the case of a patient who underwent several reconstruction steps with multiple failures including free and local flaps and cartilage harvests which showed recurrent episodes of necrosis and infection leading to melting and collapse of reconstructed structures...
February 21, 2018: Microsurgery
https://www.readbyqxmd.com/read/29464749/intraarticular-injection-autologous-platelet-rich-plasma-and-bone-marrow-concentrate-in-a-goat-osteoarthritis-model
#19
Zhen Wang, Chenjun Zhai, Hao Fei, Junzheng Hu, Weiding Cui, Zhen Wang, Zeng Li, Weimin Fan
To evaluate the effects of intraarticular injections of autologous platelet-rich plasma (PRP) or bone marrow concentrate (BMC) on osteoarthritis (OA), 24 adult goats were equally divided into control (Ctrl), saline (NS), PRP, and BMC groups, and OA was induced by surgery in NS, PRP, and BMC groups. Autologous PRP and BMC were obtained from whole blood and bone marrow aspirates, respectively. The data revealed, platelets were increased in BMC by 1.8-fold, monocytes by 5.6-fold, TGF-β1 by 7.7-fold and IGF-1 by 3...
February 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29464742/gdx-ubl4a-null-mice-exhibit-mild-kyphosis-and-scoliosis-accompanied-by-dysregulation-of-osteoblastogenesis-and-chondrogenesis
#20
Jiao Liang, Jun Li, Yanxia Fu, Fangli Ren, Jiake Xu, Mengyu Zhou, Peiyu Li, Haotian Feng, Yinyin Wang
GdX, also named ubiquitin-like protein 4A, is a ubiquitin-domain protein characterized by a ubiquitin-like domain that regulates the movement of misfolded proteins from the endoplasmic reticulum membrane to proteasome. However, its function in skeletal biology remains unclear. Here, we report that GdX plays a crucial role in skeletal development as mice lacking GdX exhibit skeletal dysplasias, mild kyphosis, and scoliosis. During embryonic stage, GdX knockout mice display decreased bone mineral density and trabecular bone accompanied by delayed osteogenic formation...
February 20, 2018: Cell Biochemistry and Function
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