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https://www.readbyqxmd.com/read/28735021/wisp1-ccn4-aggravates-cartilage-degeneration-in-experimental-osteoarthritis
#1
Martijn H van den Bosch, Arjen B Blom, Vardit Kram, Azusa Maeda, Sheena Sikka, Yankel Gabet, Tina M Kilts, Wim B van den Berg, Peter L van Lent, Peter M van der Kraan, Marian F Young
OBJECTIVE: Increased Wisp1 expression was previously reported in experimental and human osteoarthritis. Moreover, adenoviral overexpression of Wisp1 in naïve mouse knee joints resulted in early OA-like cartilage lesions. Here, we determined how the matricellular protein WISP1 is involved in the pathology that occurs in the complex osteoarthritic environment with aging and experimental osteoarthritis in wild type and Wisp1(-/-) mice. METHODS: Wild type and Wisp1(-/-) mice were aged or experimental osteoarthritis was induced with intraarticular collagenase injection, destabilization of the medial meniscus or anterior cruciate ligament transection...
July 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28734754/cost-analysis-of-microtia-treatment-in-the-netherlands
#2
M N Kolodzynski, C V A van Hövell Tot Westerflier, M Kon, C C Breugem
INTRODUCTION: Ear reconstruction for microtia is a challenging procedure. Although analyzing esthetic outcome is crucial, there is a paucity of information with regard to financial aspects of microtia reconstruction. This study was conducted to analyze the costs associated with ear reconstruction with costal cartilage in patients with microtia. METHODS: Ten consecutive children with autologous ear reconstruction of a unilateral microtia were included in this analysis...
June 28, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28734667/characterization-of-cartilage-defects-detected-by-mri-in-kellgren-lawrence-grade-0-or-1-knees
#3
Kenji Taguchi, Ko Chiba, Narihiro Okazaki, Yasuo Kido, Takashi Miyamoto, Akihiko Yonekura, Masato Tomita, Masataka Uetani, Makoto Osaki
INTRODUCTION: Osteoarthritis of the knee is generally evaluated by plain X-rays, which are incapable of detecting small cartilage damage. There are some patients who have small cartilage defects on MRI with no abnormal findings on plain X-rays. In this study, the prevalence and regional characteristics of cartilage defects detected by MRI were studied in cases with normal X-ray findings (Kellgren-Lawrence grade 0 and 1). Relationships between the cartilage defects and OA risk factors such as obesity and leg alignment were also investigated...
July 19, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28734535/transcatheter-arterial-embolization-of-abnormal-vessels-as-a-treatment-for-lateral-epicondylitis-refractory-to-conservative-treatment-a-pilot-study-with-a-2-year-follow-up
#4
Wataru Iwamoto, Yuji Okuno, Noboru Matsumura, Takao Kaneko, Hiroyasu Ikegami
BACKGROUND: Abnormal vessels and accompanying nerves are possible sources of pain with lateral epicondylitis. The purpose of this study was to describe the safety and efficacy of transcatheter arterial embolization (TAE) for lateral epicondylitis resistant to conservative treatment. METHODS: This prospective study was conducted in 24 patients with lateral epicondylitis resistant to conservative treatments for more than 3 months, with a symptom duration longer than 6 months, and with moderate to severe pain who were treated with TAE between March 2013 and October 2014...
August 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28733975/deep-convolutional-neural-network-and-3d-deformable-approach-for-tissue-segmentation-in-musculoskeletal-magnetic-resonance-imaging
#5
Fang Liu, Zhaoye Zhou, Hyungseok Jang, Alexey Samsonov, Gengyan Zhao, Richard Kijowski
PURPOSE: To describe and evaluate a new fully automated musculoskeletal tissue segmentation method using deep convolutional neural network (CNN) and three-dimensional (3D) simplex deformable modeling to improve the accuracy and efficiency of cartilage and bone segmentation within the knee joint. METHODS: A fully automated segmentation pipeline was built by combining a semantic segmentation CNN and 3D simplex deformable modeling. A CNN technique called SegNet was applied as the core of the segmentation method to perform high resolution pixel-wise multi-class tissue classification...
July 21, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28733848/femoro-acetabular-impingement-anatomic-study-of-reliability-and-accuracy-of-alpha-angle-and-offset-ratio-on-fifty-consecutive-peri-operatively-resected-femoral-heads
#6
Štěpán Magersky, Adam Král, Radovan Kubeš
PURPOSE: The purpose of this study was to determine whether X-ray attributes of the femoro-acetabular impingement (FAI) - alpha angle (AA) and offset ratio (OR) reflect real measurements on resected femoral heads. METHODS: FAI AA and OR were assessed on 50 consecutively-resected femoral heads. The parameters were measured on heads cut through the maximum range of the deformity and compared to the same parameters on standardized X-ray projections (anterior-posterior [AP] and axial views)...
July 21, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28731618/controlling-the-near-infrared-transparency-of-costal-cartilage-by-impregnation-with-clearing-agents-and-magnetite-nanoparticles
#7
Yulia Alexandrovskaya, Kirill Sadovnikov, Andrey Sharov, Anna Sherstneva, Evgeniy Evtushenko, Alexander Omelchenko, Mariya Obrezkova, Valery Tuchin, Valery Lunin, Emil Sobol
Penetration depth of near infrared laser radiation to costal cartilage is controlled by the tissue absorption and scattering and it is the critical parameter to provide the relaxation of mechanical stress throughout the whole thickness of cartilage implant. To enhance the penetration for the laser radiation on 1.56 μm the optical clearing solutions of glycerol and fructose of various concentrations are tested. The effective and reversible tissue clearance was achieved. However, the increasing absorption of radiation should be concerned: 5-8(ᴼ) C increase of tissue temperature was detected...
July 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28731616/inversion-recovery-ultrashort-echo-time-imaging-of-ultrashort-t2-tissue-components-in-ovine-brain-at-3%C3%A2-t-a-sequential-d2-o-exchange-study
#8
Shu-Juan Fan, Yajun Ma, Eric Y Chang, Graeme M Bydder, Jiang Du
Inversion recovery ultrashort echo time (IR-UTE) imaging holds the potential to directly characterize MR signals from ultrashort T2 tissue components (STCs), such as collagen in cartilage and myelin in brain. The application of IR-UTE for myelin imaging has been challenging because of the high water content in brain and the possibility that the ultrashort T2 * signals are contaminated by water protons, including those associated with myelin sheaths. This study investigated such a possibility in an ovine brain D2 O exchange model and explored the potential of IR-UTE imaging for the quantification of ultrashort T2 * signals in both white and gray matter at 3 T...
July 21, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28731483/the-role-of-laminins-in-cartilaginous-tissues-from-development-to-regeneration
#9
Y Sun, T L Wang, W S Toh, M Pei
As a key molecule of the extracellular matrix, laminin provides a delicate microenvironment for cell functions. Recent findings suggest that laminins expressed by cartilage-forming cells (chondrocytes, progenitor cells and stem cells) could promote chondrogenesis. However, few papers outline the effect of laminins on providing a favorable matrix microenvironment for cartilage regeneration. In this review, we delineated the expression of laminins in hyaline cartilage, fibrocartilage and cartilage-like tissue (nucleus pulposus) throughout several developmental stages...
July 21, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28731147/beclin-1-overexpression-inhibits-chondrocyte-apoptosis-and-downregulates-extracellular-matrix-metabolism-in-osteoarthritis
#10
Bin Song, Hong Song, Weiguo Wang, Hongru Wang, Hanyuan Peng, Jing Cui, Rong Wang, Hua Huang, Wei Wang, Lili Wang
In the present study, the expression of Beclin 1 in osteoarthritis (OA) cartilage tissue was investigated, and also its role in proliferation, apoptosis and expression of matrix metalloproteinases (MMPs) in chondrocytes obtained from patients with OA. Beclin 1 expression in cartilage tissue from OA patients, and in the age- and sex-matched controls, was detected by immunohistochemistry, semi-quantitative polymerase chain reaction and western blotting. Chondrocytes were divided into control and Beclin 1-overexpressed groups...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28730534/tracheal-cartilage-isolation-and-decellularization
#11
Zachary Galliger, Angela Panoskaltsis-Mortari
Tissue decellularization allows isolation of tissue extracellular matrix components, enabling bioengineering of native tissue microenvironments with minimal antigenic components. Here we describe a method to harvest decellularized cartilage tissue from donor trachea using a series of chemical and enzymatic washes and incorporating the extracellular matrix in gelatin methacrylate hydrogels. This decellularized cartilage tissue is easily incorporated into a variety of hydrogels to create a cartilage tissue scaffold...
July 21, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28730231/chondroprotective-effects-of-pulsed-shortwave-therapy-in-rabbits-with-experimental-osteoarthritis
#12
Rodica Ana Ungur, Adrian Florea, Alexandru Flaviu Tăbăran, Iuliu Călin Scurtu, Ioan Onac, Ileana Monica Borda, László Irsay, Viorela Mihaela Ciortea, Eleonora Dronca, Mihnea Tudor Zdrenghea, ŞoimiŢa Mihaela Suciu
INTRODUCTION: Osteoarthritis (OA) represents a public health challenge since the pathogenic treatment, able to induce cartilage regeneration, still remains unknown. Ageing of the population and increasing OA prevalence have led to a lot of research, aiming to identify treatments acting on chondrocytes that play a determinant role in cartilage degeneration÷regeneration balance. Pulsed shortwave therapy (with the classical application form - Diapulse) is a physiotherapy method with anabolic effects demonstrated on nervous, conjunctive and vascular tissues, but its effects on OA cartilage are not known...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28730221/usefulness-of-ultrastructure-studies-for-the-estimation-of-the-postmortem-interval-a-systematic-review
#13
Sorin Hostiuc, Mugurel Constantin Rusu, Vasile Sorin Mănoiu, Alexandra Diana Vrapciu, IonuŢ Negoi, Maria Viorela Popescu
Establishing the postmortem interval (PMI) is vital in legal medicine as it allows to retrospectively estimate the hour of death, which is essential for the police as a starting point for their inquiries (especially in violent deaths). Ultrastructure studies aimed specifically to detect autolytic changes are scarcely identified in the scientific literature. Moreover, they are performed in a variety of conditions (different temperatures, species, in vitro ÷ in situ, and so on), making the results difficult to interpret for legal medicine purposes...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28729949/modeling-the-effect-of-blunt-impact-on-mitochondrial-function-in-cartilage-implications-for-development-of-osteoarthritis
#14
Georgi I Kapitanov, Bruce P Ayati, James A Martin
OBJECTIVE: Osteoarthritis (OA) is a disease characterized by degeneration of joint cartilage. It is associated with pain and disability and is the result of either age and activity related joint wear or an injury. Non-invasive treatment options are scarce and prevention and early intervention methods are practically non-existent. The modeling effort presented in this article is constructed based on an emerging biological hypothesis-post-impact oxidative stress leads to cartilage cell apoptosis and hence the degeneration observed with the disease...
2017: PeerJ
https://www.readbyqxmd.com/read/28729762/combination-of-bone-marrow-mesenchymal-stem-cells-and-cartilage-fragments-contribute-to-enhanced-repair-of-osteochondral-defects
#15
Mohammed Abbas
Cartilage tissue engineering using stem cells and biomaterials is considered a promising approach despite poor outcomes. We hypothesise that articular cartilage fragments provides native environmental cues to enhance stem cell differentiation. As such we evaluated the chondrogenic differentiation and repair of critical size defect in a human explant osteochondral model (OD) using bone marrow derived mesenchymal stem cells (BM-MSCs) and homogenised cartilage. BM-MSCs were established from the bone-marrow plugs of patients undergoing total knee arthroplasty and characterized...
2017: Bioinformation
https://www.readbyqxmd.com/read/28729605/evaluating-the-effects-of-material-properties-of-artificial-meniscal-implant-in-the-human-knee-joint-using-finite-element-analysis
#16
Duraisamy Shriram, Gideon Praveen Kumar, Fangsen Cui, Yee Han Dave Lee, Karupppasamy Subburaj
Artificial meniscal implants may replace severely injured meniscus and restore the normal functionality of the knee joint. Implant material stiffness and shape influence the longevity of implantations. This study, using 3D finite element analysis, aimed to evaluate the effects of material stiffness variations of anatomically shaped artificial meniscal implant in the knee joint. Finite element simulations were conducted on five different cases including intact knee, medial meniscectomized knee, and the knee joint with the meniscal implant with three distinct material stiffness...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729059/ultrasonographic-assessment-of-femoral-cartilage-thickness-in-patients-with-cerebral-palsy
#17
Emre Adigüzel, Fatih Tok, Emre Ata, Evren Yaşar, Bilge Yilmaz
BACKGROUND: Cerebral palsy (CP) is one of the most disabling syndromes of children. To our knowledge, there has not yet been any reported evaluation of the effect of CP on distal femoral cartilage by ultrasonography. The value of understanding this effect on cartilage is that sonographic evaluation of cartilage thickness may help physician to predict the joint health of these children. OBJECTIVE: To determine whether femoral cartilage thickness in patients with CP is different from that of healthy control subjects...
July 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28728820/role-of-piezo-channels-in-joint-health-and-injury
#18
W Lee, F Guilak, W Liedtke
Cartilage is an intrinsically mechanically sensitive tissue composed of chondrocytes as the only cell type. Chondrocyte mechanotransduction is not well understood, but recently we identified critical components of the mechanotransduction machinery demonstrating how mechanical stimulation of these cells can be converted into cellular calcium signals. Physiologic mechanical cues induce anabolic responses of (post-mitotic) chondrocytes via transient receptor potential vanilloid 4 ion channels, whereas injurious mechanical stress is transduced by Piezo1 jointly with Piezo2 ion channels...
2017: Current Topics in Membranes
https://www.readbyqxmd.com/read/28728606/levels-of-serum-biomarkers-from-a-two-year-multicentre-trial-are-associated-with-treatment-response-on-knee-osteoarthritis-cartilage-loss-as-assessed-by-magnetic-resonance-imaging-an-exploratory-study
#19
Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Mineau, François Abram, Patrice Paiement, Philippe Delorme, Jean-Pierre Pelletier
BACKGROUND: There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with knee OA, the likelihood of some serum biomarkers to be associated with a better response to chondroitin sulfate in reducing cartilage volume loss. METHODS: Eight biomarkers were studied: hyaluronic acid (HA), C reactive protein (CRP), adipsin, leptin, N-terminal propeptide of collagen IIα (PIIANP), C-terminal crosslinked telopeptide of type I collagen (CTX-1), matrix metalloproteinase-1 (MMP-1), and MMP-3...
July 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28727652/surgical-emphysema-following-canalplasty-for-aural-exostoses
#20
Michael C Baxter, Matthew Keller, Anil Shah, Sean Wise
OBJECTIVE: To describe the presentation and management of surgical emphysema involving the temporomandibular joint and deep neck following exostoses removal. PATIENT: A 60-year-old male surfer presented with hearing loss and recurrent infections in the right ear. An examination revealed obstructing bony exostoses in the right external auditory canal. He underwent right canalplasty using a postauricular approach. At 5 weeks after surgery, he presented with right otalgia, swelling of the right face and neck, and complaints of a squeaking noise in the right ear with mandibular excursions...
July 19, 2017: Otology & Neurotology
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