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https://www.readbyqxmd.com/read/29909583/clinical-and-radiographical-ten-years-long-term-outcome-of-microfracture-vs-autologous-chondrocyte-implantation-a-matched-pair-analysis
#1
Robert Ossendorff, Kilian Franke, Benjamin Erdle, Markus Uhl, Norbert P Südkamp, Gian M Salzmann
PURPOSE: To compare the clinical and radiographical long-term outcome of microfracture (MFX) and first-generation periosteum-covered autologous chondrocyte implantation (ACI-P). METHODS: All subjects (n = 86) who had been treated with knee joint ACI-P or microfracture (n = 76) with a post-operative follow-up of at least ten years were selected. Clinical pre- and post-operative outcomes were analyzed by numeric analog scale (NAS) for pain, Lysholm, Tegner, IKDC, and KOOS score...
June 16, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29909435/photobiomodulation-therapy-pbmt-on-acute-pain-and-inflammation-in-patients-who-underwent-total-hip-arthroplasty-a-randomized-triple-blind-placebo-controlled-clinical-trial
#2
Luciana Gonçalves Langella, Heliodora Leão Casalechi, Shaiane Silva Tomazoni, Douglas Scott Johnson, Regiane Albertini, Rodney Capp Pallotta, Rodrigo Labat Marcos, Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior
When conservative treatments fail, hip osteoarthritis (OA), a chronic degenerative disease characterized by cartilage wear, progressive joint deformity, and loss of function, can result in the need for a total hip arthroplasty (THA). Surgical procedures induced tissue trauma and incite an immune response. Photobiomodulation therapy (PBMt) using low-level laser therapy (LLLT) and/or light-emitting diode therapy (LEDT) has proven effective in tissue repair by modulating the inflammatory process and promoting pain relief...
June 16, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29908759/cutibacterium-acnes-and-the-shoulder-microbiome
#3
Boyang Qiu, Kait Al, Ana M Pena-Diaz, George S Athwal, Darren Drosdowech, Kenneth J Faber, Jeremy P Burton, David B O'Gorman
BACKGROUND: Advances in DNA sequencing technologies have made it possible to detect microbial genome sequences (microbiomes) within tissues once thought to be sterile. We used this approach to gain insights into the likely sources of Cutibacterium acnes (formerly Propionibacterium acnes) infections within the shoulder. METHODS: Tissue samples were collected from the skin, subcutaneous fat, anterior supraspinatus tendon, middle glenohumeral ligament, and humeral head cartilage of 23 patients (14 male and 9 female patients) during primary arthroplasty surgery...
June 13, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29908452/transcriptomics-provides-mechanistic-indicators-of-fluoride-toxicology-on-endochondral-ossification-in-the-hind-limb-of-bufo-gargarizans
#4
Wu Chao, Yuhui Zhang, Lihong Chai, Hongyuan Wang
Endochondral ossification, the process by which most of the bone is formed, is regulated by many specific groups of molecules and extracellular matrix components. Hind limb of Bufo gargarizans is a model to study endochondral ossification during metamorphosis. Chinese toad (Bufo gargarizans) were exposed to different fluoride concentrations (0, 1, 5, 10 and 20 mg L-1 ) from G3 to G42. The development of hind limb of B. gargarizans was observed using the double staining methodology. The transcriptome of hind limb of B...
June 10, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29907992/surface-chemistry-substrate-and-topography-guide-the-behavior-of-human-articular-chondrocytes-cultured-in-vitro
#5
Natasja Leth Bergholt, Morten Foss, Anwer Saeed, Nikolaj Gadegaard, Helle Lysdahl, Martin Lind, Casper Bindzus Foldager
Understanding the behavior of chondrocytes in contact with artificial culture surfaces is becoming increasingly important in attaining appropriate ex vivo culture conditions of chondrocytes in cartilage regeneration. Chondrocyte transplantation-based cartilage repair requires efficiently expanded chondrocytes and the culture surface plays an important role in guiding the behavior of the cell. Micro- and nanoengineered surfaces make it possible to modulate cell behavior. We hypothesized that the combined influence of topography, substrate, and surface chemistry may affect the chondrocyte culturing in terms of proliferation and phenotypic means...
June 16, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29907764/long-non-coding-rna-hotair-promotes-osteoarthritis-progression-via-mir-17-5p-fut2-%C3%AE-catenin-axis
#6
Jialei Hu, Zi Wang, Yujia Shan, Yue Pan, Jia Ma, Li Jia
Osteoarthritis (OA) is a chronic joint disease and hard to cure at present. Accumulating evidence suggests long noncoding RNA-HOTAIR (lncRNA-HOTAIR) plays important role in OA progression. However, the underlying molecular mechanism of HOTAIR in OA progression has not been well elucidated. In the present study, we identified that HOTAIR level was upregulated in OA cartilage tissues. High expression of HOTAIR was correlated with modified Mankin scale, extracellular matrix (ECM) degradation and chondrocytes apoptosis...
June 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29907523/effect-of-the-calcaneal-medializing-osteotomy-on-soft-tissues-supporting-the-plantar-arch-a-computational-study
#7
R Larrainzar-Garijo, C Cifuentes de la Portilla, B Gutiérrez-Narvarte, E Díez-Nicolás, J Bayod
Medializing calcaneal osteotomy forms part of the treatment options for adult acquired flat foot. The structural correction that is achieved is widely known. However, the effect of this procedure on the soft tissues that support the plantar arch has been little studied, since it is not possible to quantify experimentally the tension and deformation variations generated. Therefore, the objective of this study was to evaluate the effect of medializing calcaneal osteotomy on the soft tissue that supports the plantar arch, using a computational model of the human foot designed with a clinical approach...
June 12, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29907324/nonlinear-effects-of-caffeine-on-the-viability-synthesis-and-gene-expression-of-chondrocytes-from-the-offspring-of-rats-treated-during-pregnancy
#8
Amanda Maria Sena Reis, Karina Pessoa Oliveira, Isabela Helena Fagundes de Paula, Alisson Paulo da Silva, Júlia Fahrion Tarragô, Natália de Melo Ocarino, Rogéria Serakides
OBJECTIVE: Evaluate the effects of doses of caffeine administered to pregnant rats on the articular cartilage chondrocytes of their offspring. METHODS: Twenty-four adult Wistar rats were randomly assigned to four groups, with one control group and three groups being treated with caffeine at doses of 25, 50 and 100 mg/kg throughout pregnancy. At birth, three offspring/females were euthanized so that the chondrocytes could be extracted. At 7, 14 and 21 days of culture, the chondrocytes were subjected to the MTT cell viability assay and an evaluation of their alkaline phosphatase activity and collagen synthesis...
June 12, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29907111/changes-in-biomarkers-in-equine-synovial-fluid-two-weeks-after-intra-articular-hyaluronan-treatment-a-randomised-double-blind-clinical-trial
#9
Tytti M Niemelä, Riitta-Mari Tulamo, Kaisa Aaltonen, Satu M Sankari, Anna K Hielm-Björkman
BACKGROUND: Inflammatory and degenerative activity inside the joint can be studied in vivo via analysis of synovial fluid (SF) biomarkers, which are molecular markers of inflammatory processes and tissue turnover. The aim of this study was to investigate the response of selected biomarkers in the SF after an intra-articular (IA) high-molecular-weight non-animal stabilized hyaluronic acid (NASHA) treatment. Our hypothesis was that prostaglandin E2 (PGE2 ), substance P, aggrecan chondroitin sulfate 846 epitope (CS846), and carboxypeptide of type II collagen (CPII) concentrations in SF would decrease more in the NASHA than in the placebo group...
June 15, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29906711/postnatal-expression-of-chondrogenic-and-osteogenic-regulatory-factor-mrna-in-the-rat-condylar-cartilage
#10
Mohamad Al-Dujaili, Trudy J Milne, Richard D Cannon, Mauro Farella
OBJECTIVES: The condylar cartilage is a key site of growth and development of the mandible. The aim of this research was to determine the mRNA expression levels of a number of chondrogenic and osteogenic regulatory factors in the condylar cartilage of the postnatal rat. MATERIALS AND METHODS: Condyles were extracted from 40 rats aged 4, 10, 21 or 90 days with 10 rats assigned to each age group. The condyles from one rat from each age group was fixed and decalcified in 10% EDTA for histology...
June 1, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29906555/injectable-liquid-polymers-extend-the-delivery-of-corticosteroids-for-the-treatment-of-osteoarthritis
#11
Edgardo Rivera-Delgado, Ashley Djuhadi, Chaitanya Danda, Jonathan Kenyon, João Maia, Arnold I Caplan, Horst A von Recum
Drug delivery strategies generally use inert materials, such as high molecular weight polymers, to encapsulate and control the release rate of therapeutic drugs. Diffusion governs release and depends on the ease of permeation of the polymer alongside the device thickness. Yet in applications such as osteoarthritis, the physiological constraints and limited intra-articular joint space prevent the use of large, solid drug delivery implants. Other investigators have explored the use of micro- and nanoparticle drug delivery systems...
June 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29906221/presurgical-preparation-of-infants-with-unilateral-cleft-lip-and-palate-the-sac-pp-mr-innovative-technique
#12
Ricardo Elizondo, Manuel O Lagravère, Esthela Flores, Nora Letechipía
In this article, we demonstrate an effective, cheap, and fast way to shape the nasal alar cartilage in patients with unilateral cleft lip and palate. This technique straightens the vomer and brings the philtrum, columella, premaxilla, and the maxillary frenum to the midsagittal plane, while the alveolar ridges are shaped and positioned. This reduces the lip and palatal cleft to zero even in a 4-week period.
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29905411/anti-inflammatory-and-antioxidant-effects-of-mesenchymal-and-hematopoietic-stem-cells-in-a-rheumatoid-arthritis-rat-model
#13
Hanan Abdelmawgoud, Asmaa Saleh
BACKGROUND: Mesenchymal stem cells (MSCs) are of increased importance because of their capacity to counteract inflammation and suppress host immune responses. OBJECTIVES: The aim of the study was to compare the effectiveness of MSCs and hematopoietic stem cells (HSCs) in the treatment of rheumatoid arthritis (RA). MATERIAL AND METHODS: Paw swelling was assessed by measuring the thickness of the hind paws using a caliper. Cytokines - interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and IL-10 - and rheumatoid factor (RF) were measured using enzyme-linked immunosorbent assay (ELISA) kits...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905408/ginkgolide-b-exerts-anti-inflammatory-and-chondroprotective-activity-in-lps-induced-chondrocytes
#14
Hejia Hu, Yan Li, Zengfeng Xin, Xiangfeng Zhanga
BACKGROUND: Osteoarthritis (OA) is one of degenerative and chronic diseases of articular joints. Articular cartilage is an avascular tissue, and its primary cellular component is chondrocytes. The main characteristic of OA is non-classic inflammation and cartilage degeneration. Ginkgolide B (GB) is a component of Ginkgo biloba which has diverse bioactivities. OBJECTIVES: The present study uses an in vitro experimental model to detect the underlying anti-inflammatory and chondroprotective effects of GB and provides a new way for future clinical therapy of OA...
June 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905361/treatment-of-osteoarthritis-with-collagen-based-scaffold-a-porcine-animal-model-with-xenograft-mesenchymal-stem-cells
#15
Wo-Ran Tzeng, Shu-Wei Huang, Chih-Hsiang Fang, Lih-Tao Hsu, Chih-Yu Chen, Hsin-Hsin Shen, Jenny Zwei-Chieng Chang, Jui-Sheng Sun, Feng-Huei Lin
OBJECTIVE: With the goal to explore a new approach to treat the early degenerative lesions of hyaline cartilage, we implanted in a porcine OA model a collagen-based scaffold containing chondroprogenitor cells derived from human bone marrow mesenchymal stem cells (hBM-MSCs). EXPERIMENTAL DESIGN: Porcine knee joints were subjected to anterior cruciate ligament (ACL) transection to surgically induce OA. After 4 months, the time necessary for the development of cartilage surface damage, animals were treated either with trephination bone plug wrapped with the chondroprogenic hBM-MSCs-embedded collagen scaffold or microfractures alone...
June 15, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29905059/-current-progress-of-laser-assisted-cartilage-reshaping-for-prominent-ear
#16
REVIEW
Fengfeng Guo, Xiaobo Yu, Haiyue Jiang
Objective: To summarize the current progress of laser-assisted cartilage reshaping (LACR) for prominent ear. Methods: The domestic and abroad article concerning the LACR in treatment of prominent ear was reviewed and analyzed. Results: As a new technique, there were three types of LACR therapies that been used for prominent ear. LACR with the 1 064 nm Nd/YAG laser is painful and the penetration depth of the 1 064 nm Nd/YAG laser is greater than that of the 1540 nm Er/Glass laser which is caused more tissue injury...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29905056/-research-progress-of-porous-tantalum-in-bone-tissue-engineering
#17
REVIEW
Xiaoquan Ding, Xingwang Liu, Jun Chen, Shiyi Chen
Objective : To review the basical research progress of porous tantalum in bone tissue engineering. Methods: The related basical research in fabrication, cytobiology, and surface modification of porous tantalum was reviewed and analyzed. Results: The outstanding physiochemical properties of porous tantalum granted its excellent performance in biocompatibility and osteointegration, as well as promoting cartilage and tendon tissue restoration...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904041/anti-vascular-endothelial-growth-factor-vegf-antibody-ameliorates-cartilage-degradation-in-a-rat-model-of-chronic-sports-arthritic-injury
#18
Lei Shang, Yong Xu, Changqing Shao, Chao Ma, Yanbo Feng
BACKGROUND Although a relationship between vascular endothelial growth factor (VEGF) and articular cartilage degeneration has been reported, little is known regarding its role in articular cartilage injury induced by sports activities. In this study, we evaluated the role of VEGF in a rat model of chronic sports arthritic injury. MATERIAL AND METHODS Animals were divided into 3 groups: Control (n=10), Vehicle (chronic sports arthritic injury, n=10), and Bevacizumab (chronic sports arthritic injury treated with anti-VEGF monoclonal antibody Bevacizumab, n=10)...
June 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29903423/comparison-of-morphological-changes-and-tactile-sensitivity-of-the-pharynx-and-larynx-between-four-standing-sedative-and-analgesic-protocols-in-eight-adult-healthy-horses
#19
Guillaume Manneveau, Jeanne Lecallard, Chantal Thorin, Hugo Pamela, Caroline Tessier
OBJECTIVE: To compare the topographic modifications and tactile sensitivity of the pharynx and larynx after administration of four sedative and analgesic protocols in standing horses. STUDY DESIGN: Experimental, observer-blinded, crossover study. ANIMALS: Eight healthy mares. METHODS: Five protocols were evaluated: 1) xylazine and butorphanol administered intravenously (IV); 2) detomidine and butorphanol administered IV; 3) xylazine administered IV and lidocaine topically; 4) detomidine administered IV and lidocaine topically and 5) no analgesia or sedation (control)...
May 1, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29902525/propolis-extract-a-new-reinforcement-material-in-improving-bone-healing-an-in-vivo-study
#20
Abdolhamid Meimandi-Parizi, Ahmad Oryan, Emad Sayahi, Amin Bigham-Sadegh
BACKGROUND: propolis is known for its antioxidant, immune response modulating, and wound healing effects. In the present study in order to determine the bone healing capacity of the propolis extract, a critical sized, nonunion, radial bone defect model was repaired in rat, using chitosan and demineralized bone matrix (DBM) scaffolds along with propolis extract. MATERIALS AND METHODS: Seventy-two radial bone defects in 36 healthy male rats were randomly divided into 6 groups (n= 12/group)...
June 11, 2018: International Journal of Surgery
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