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https://www.readbyqxmd.com/read/28823024/effect-of-kaempferia-parviflora-extract-on-knee-osteoarthritis
#1
Hiroko Kobayashi, Ryo Suzuki, Kei Sato, Takatoshi Ogami, Hiroshi Tomozawa, Masahito Tsubata, Koji Ichinose, Masaki Aburada, Wataru Ochiai, Kiyoshi Sugiyama, Tsutomu Shimada
Knee osteoarthritis (OA) is becoming more prevalent worldwide due to increases in the numbers of elderly and obese patients. Currently, pharmaceutical medicines used for the treatment of OA are for symptomatic therapy and therefore new therapeutic agents are needed. Kaempferia parviflora (KP) is a plant growing naturally in Southeast Asia and has various pharmacological effects including an anti-inflammatory effect, but no effect on OA has yet been reported. We therefore conducted a search for the effects KP and the active components of KP extract (KPE) exert on OA as well as its mechanism of action...
August 19, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28822634/development-and-efficacy-testing-of-a-hollow-awl-that-leads-to-patent-bone-marrow-channels-and-greater-mesenchymal-stem-cell-mobilization-during-bone-marrow-stimulation-cartilage-repair-surgery
#2
Byoung-Hyun Min, Minh-Dung Truong, Hyung Keun Song, Jae Ho Cho, Do Young Park, Heon Ju Kweon, Jun Young Chung
PURPOSE: To investigate whether microfracture with a cannulated hollow awl can yield more patent marrow channels and allow greater mobilization of the reparable cells to the defect compared to the conventional awl with blunt end in human knee joints. METHODS: Patients who were planned for 1-stage bilateral total knee arthroplasty due to degenerative osteoarthritis with well-preserved lateral femoral condylar cartilage were retrospectively included. A 10-mm × 20-mm, rectangular, full-thickness chondral defect was made on the lateral femoral condyle on each knee joint...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822094/quantitative-knee-cartilage-measurement-at-mr-imaging-of-patients-with-anterior-cruciate-ligament-tear
#3
Kazuki Kato, Tamotsu Kamishima, Eiji Kondo, Tomohiro Onodera, Shota Ichikawa
In previous studies, numerous approaches were proposed that assess knee cartilage volume quantitatively using 3D magnetic resonance (MR) imaging. However, the clinical use of these approaches is limited because 3D MR is prone to metal artifacts in postoperative cases. Our purpose in this study was to validate a method for knee cartilage volume quantification using conventional MR imaging in patients who underwent anterior cruciate ligament (ACL) reconstruction surgery. The study included 16 patients who underwent MR imaging before and 1 year after ACL reconstruction surgery...
August 18, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28821957/co-culture-of-chondrons-and-mesenchymal-stromal-cells-reduces-the-loss-of-collagen-vi-and-improves-extracellular-matrix-production
#4
H A Owida, T De Las Heras Ruiz, A Dhillon, Y Yang, N J Kuiper
Adult articular chondrocytes are surrounded by a pericellular matrix (PCM) to form a chondron. The PCM is rich in hyaluronan, proteoglycans, and collagen II, and it is the exclusive location of collagen VI in articular cartilage. Collagen VI anchors the chondrocyte to the PCM. It has been suggested that co-culture of chondrons with mesenchymal stromal cells (MSCs) might enhance extracellular matrix (ECM) production. This co-culture study investigates whether MSCs help to preserve the PCM and increase ECM production...
August 19, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28821460/long-term-effects-of-hydrogen-sulfide-on-the-anabolic-catabolic-balance-of-articular-cartilage-in-vitro
#5
A Vela-Anero, T Hermida-Gomez, L Gato-Calvo, C Vaamonde-García, S Diaz-Prado, R Meijide-Faílde, F J Blanco, E F Burguera
Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition of the synthesis of extracellular matrix (ECM) proteins, as well as an increase in proteases. This eventually leads to a predominance of the catabolic phenotype and the progressive loss of articular cartilage. Hydrogen sulfide (H2S) is a small gaseous molecule recognized as the third endogenous gasotransmitter...
August 15, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28820949/association-between-patient-factors-and-outcome-of-synthetic-cartilage-implant-hemiarthroplasty-vs-first-metatarsophalangeal-joint-arthrodesis-in-advanced-hallux-rigidus
#6
Andy Goldberg, Dishan Singh, Mark Glazebrook, Chris M Blundell, Gwyneth De Vries, Ian L D Le, Dominic Nielsen, M Elizabeth Pedersen, Anthony Sakellariou, Matthew Solan, Alastair S E Younger, Timothy R Daniels, Judith F Baumhauer
BACKGROUND: We evaluated data from a clinical trial of first metatarsophalangeal joint (MTPJ1) implant hemiarthroplasty and arthrodesis to determine the association between patient factors and clinical outcomes. METHODS: Patients ≥18 years with hallux rigidus grade 2, 3, or 4 were treated with synthetic cartilage implant MTPJ1 hemiarthroplasty or arthrodesis. Pain visual analog scale (VAS), Foot and Ankle Ability Measure (FAAM) sports and activities of daily living (ADL) scores, and Short Form-36 Physical Function (SF-36 PF) subscore were obtained preoperatively, and at 2, 6, 12, 24, 52, and 104 weeks postoperatively...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28820829/primary-septal-cartilage-graft-for-the-unilateral-cleft-rhinoplasty
#7
Xiaona Lu, Guocheng Chen
No abstract text is available yet for this article.
August 10, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28820828/reply-letter-to-the-editor-primary-septal-cartilage-graft-for-the-unilateral-cleft-rhinoplasty
#8
Ting-Chen Lu, Chuan-Fong Yao, Susie Lin, Philip Kuo-Ting Chen
No abstract text is available yet for this article.
August 10, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28820271/cam-deformities-and-limited-hip-range-of-motion-are-associated-with-early-osteoarthritic-changes-in-adolescent-athletes-a-prospective-matched-cohort-study
#9
Cody C Wyles, Germán A Norambuena, Benjamin M Howe, Dirk R Larson, Bruce A Levy, Brandon J Yuan, Robert T Trousdale, Rafael J Sierra
BACKGROUND: The natural history of femoroacetabular impingement (FAI) remains incompletely understood. In particular, there is limited documentation of joint damage in adolescent patients with limited range of motion (LROM) of the hip, which is commonly associated with FAI. PURPOSE: To evaluate changes in magnetic resonance imaging (MRI), radiographs, and clinical examinations over 5 years in a group of athletes from a wide variety of sports with asymptomatic LROM of the hip compared with matched controls...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28819826/the-outcome-of-the-partial-resurfacing-arthroplasty-of-the-hip-shows-high-numbers-of-failures-and-conversion-to-total-arthroplasty
#10
Thilo Floerkemeier, Stefan Budde, Nils Wirries, Gabriela von Lewinski, Henning Windhagen, Marco Ezechieli
PURPOSE: Local cartilage and bony defects, which are too large for joint preserving cartilage treatment are difficult to treat. The implantation of a mini-resurfacing implant (Hemicap®, 2med, Hamburg, Germany) may be a possible alternative treatment for these patients. This partial replacement fills the defect and restores a smooth and continuous articular surface. The aim of this study was to determine short- to midterm results of the treatment of local cartilage defects of the femoral head using the Hemicap®...
August 17, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28819701/suppressive-effects-of-tsahc-in-an-experimental-mouse-model-and-fibroblast-like-synoviocytes-of-rheumatoid-arthritis
#11
Min-Gyu Jeon, Yun-Hong Cheon, Hye-Song Lim, Sang Mi Yi, Young Sun Suh, Hyun-Ok Kim, Young-Sool Hah, Ki-Hun Park, Hae Sook Noh, Sang-Il Lee
The purpose of this study is to investigate the effect of TSAHC [4'-(p-toluenesulfonylamido)-4-hydroxychalcone] in K/BxN serum transfer arthritis model and fibroblast-like synoviocytes of rheumatoid arthritis (RA-FLS). In in vivo experiments, TSAHC attenuated the incidence and severity of arthritis in comparison with the vehicle group. Histological findings showed that TSAHC decreased the inflammation, bone erosion, cartilage damage, and osteoclasts activity in the ankle. Furthermore, we confirmed by biochemical analysis that the observations were associated with the decreased expression of proinflammatory cytokines, matrix metalloproteinases (MMPs), and RANKL in serum and ankle...
August 17, 2017: Inflammation
https://www.readbyqxmd.com/read/28819688/airway-reconstruction-using-decellularized-tracheal-allografts-in-a-porcine-model
#12
Michinobu Ohno, Yasushi Fuchimoto, Huai-Che Hsu, Masataka Higuchi, Makoto Komura, Tetsuji Yamaoka, Akihiro Umezawa, Shin Enosawa, Tatsuo Kuroda
PURPOSE: Tracheal cartilage reconstruction is an essential approach for the treatment of tracheal congenital abnormalities or injury. Here, we evaluated the use of allogeneic decellularized tracheas as novel support scaffolds. METHODS: Six weaned pigs (4-week-old domestic males) were transplanted with allogeneic tracheal graft patches (three decellularized and three fresh tracheal scaffolds) onto artificial defects (approximately 15 × 15 mm). After 11 weeks, the tracheas were evaluated by bronchoscopy and histological studies...
August 17, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28819590/minimally-invasive-total-hip-replacement-in-an-ipsilateral-post-traumatic-above-knee-amputation-a-case-report
#13
Sanjeev Patnaik, Biswaranjan Nayak, Akshaya Kumar Sahoo, Nabin Kumar Sahu
INTRODUCTION: Total hip replacement (THR) is a highly successful operation in alleviating pain and improving the overall function of the hip, in end-stage arthritis of the hip, in otherwise fit patients. However, THR as a surgical option in post-traumatic hip arthritis with ipsilateral above-knee amputation is rarely reported. CASE REPORT: We are presenting a case report of a 30-year-old male, who had previously underwent an above-knee amputation due to road-traffic accident, presenting 24 h after the injury with segmental fracture femur and popliteal artery laceration, for which the limb could not be salvaged...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28819366/paracrine-potential-of-the-human-adipose-tissue-derived-stem-cells-to-modulate-balance-between-matrix-metalloproteinases-and-their-inhibitors-in-the-osteoarthritic-cartilage-in-vitro
#14
Jaroslav Denkovskij, Edvardas Bagdonas, Ilona Kusleviciute, Zygmunt Mackiewicz, Ausra Unguryte, Narunas Porvaneckas, Sandrine Fleury, Algirdas Venalis, Christian Jorgensen, Eiva Bernotiene
Adipose tissue represents an abundant source of stem cells. Along with anti-inflammatory effects, ASC secrete various factors that may modulate metabolism of extracellular matrix in osteoarthritic (OA) cartilage, suggesting that the presence of ASC could be advantageous for OA cartilage due to the recovery of homeostasis between matrix metalloproteinases (MMPs) and their tissue inhibitors of metalloproteinases (TIMPs). To evaluate these effects, cartilage explants (CE) were cocultured with ASC for 3 and 7 days under stimulation with or without IL-1β...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28818745/a-systematic-review-on-the-role-of-eicosanoid-pathways-in-rheumatoid-arthritis
#15
REVIEW
Malvina Hoxha
BACKGROUND: Rheumatoid arthritis is characterized by the production of eicosanoids, cytokines, adhesion molecules, infiltration of T and B lymphocytes in the synovium and oxygen reduction accompanied by the cartilage degradation. Eicosanoids are responsible for the progressive destruction of cartilage and bone, however neither steroids, nor the non steroidal anti-inflammatory drugs (NSAIDs), cannot slow down cartilage and bone destruction providing only symptomatic improvement. The current rheumatoid arthritis treatment options include mainly the use of disease-modifying anti-rheumatic drugs, the corticosteroids, the NSAIDs and biological agents...
August 14, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28818737/genome-wide-dna-methylation-profiling-of-articular-cartilage-reveals-significant-epigenetic-alterations-in-kashin-beck-disease-and-osteoarthritis
#16
Wenyu Wang, Yan Yu, Jingcan Hao, Yan Wen, Jing Han, Weikun Hou, Ruiyu Liu, Bo Zhao, Awen He, Ping Li, Qianrui Fan, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Xiong Guo, Feng Zhang
OBJECTIVE: To determine genome-wide DNA methylation profiles of knee cartilage from patients with Kashin-Beck disease (KBD) and osteoarthritis (OA). METHOD: Knee cartilage was collected from 14 grade III KBD patients, 5 primary OA patients and 13 healthy subjects. The genome-wide methylation profiles of 5 KBD cartilage, 5 OA cartilage and 5 normal cartilage were determined by Illumina HumanMethylation450 array. Illumina Methylation Analyzer package was employed for identifying differentially methylated CpG sites...
August 14, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28818689/sol-gel-derived-hydroxyapatite-films-over-porous-calcium-polyphosphate-substrates-for-improved-tissue-engineering-of-osteochondral-like-constructs
#17
Whitaik David Lee, Rahul Gawri, Robert M Pilliar, William L Stanford, Rita A Kandel
Integration of in vitro-formed cartilage on a suitable substrate to form tissue-engineered implants for osteochondral defect repair is a considerable challenge. In healthy cartilage, a zone of calcified cartilage (ZCC) act as an intermediary for mechanical force transfer from soft to hard tissue, as well as an effective interlocking structure to better resist interfacial shear forces. We have developed biphasic constructs that consist of scaffold-free cartilage tissue grown in vitro on, and interdigitated with, porous calcium polyphosphate (CPP) substrates...
August 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28818625/the-therapeutic-potential-of-crth2-dp2-beyond-allergy-and-asthma
#18
REVIEW
Katharina Jandl, Akos Heinemann
Prostaglandin (PG) D2 has been in the focus of research for quite a long time, but its biological effects and its roles in human disease are still not fully characterized. When in 2001 a second major PGD2 receptor termed chemoattractant receptor homologue expressed on Th2 cells (CRTH2; alternative name DP2) was discovered, diverse investigations started to shed more light on the complex and often controversial actions of the prostaglandin. With various immunomodulating effects, such as induction of migration, activation, and cytokine release of leukocytes observed both in vivo and in vitro, CRTH2 has emerged as a promising target for the treatment of allergic diseases...
August 14, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28818159/effects-of-iron-administration-on-the-diameter-of-cells-of-growth-cartilage-of-rat-pups-during-pregnancy
#19
Faiza Umbreen, Khadija Qamar, Sadia Shaukat, Amna Tasawar
OBJECTIVE: To determine the effect of oral iron administration on pregnant rats on the diameter of cells of growth plate of rat pups. STUDY DESIGN: Experimental study. PLACE AND DURATION OF STUDY: Anatomy Department, Army Medical College, Rawalpindi in collaboration with National Institute of Health (NIH), Islamabad from March to November 2016. METHODOLOGY: Group Acontaining 8 pregnant rats was control group, and group B containing same number of pregnant rats was the study group...
July 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28817971/effects-of-solid-acellular-type-i-iii-collagen-biomaterials-on-in-vitro-and-in-vivo-chondrogenesis-of-mesenchymal-stem-cells
#20
Liang Gao, Patrick Orth, Magali Cucchiarini, Henning Madry
Type-I/III collagen membranes are advocated for clinical use in articular cartilage repair as being able of inducing chondrogenesis, a technique termed autologous matrix-induced chondrogenesis (AMIC). Area covered: The current in vitro and translational in vivo evidence for chondrogenic effects of solid acellular type-I/III collagen biomaterials. Expert commentary: In vitro, mesenchymal stem cells (MSCs) adhere to the fibers of the type-I/III collagen membrane. No in vitro study provides evidence that a type-I/III collagen matrix alone may induce chondrogenesis...
August 18, 2017: Expert Review of Medical Devices
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