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https://www.readbyqxmd.com/read/28220902/twist1-induces-mmp3-expression-through-up-regulating-dna-hydroxymethylation-and-promotes-catabolic-responses-in-human-chondrocytes
#1
Joe Hasei, Takeshi Teramura, Toshiyuki Takehara, Yuta Onodera, Takuro Horii, Merissa Olmer, Izuho Hatada, Kanji Fukuda, Toshifumi Ozaki, Martin K Lotz, Hiroshi Asahara
The objective was to investigate the levels of TWIST1 in normal and OA cartilage and examine its role in regulating gene expression in chondrocytes. Human cartilage tissues and chondrocytes were obtained at autopsy from normal knee joints and from OA-affected joints at the time of total knee arthroplasty. TWIST1 expression was increased in human OA knee cartilage compared to normal knee cartilage. TWIST1 induced matrix metalloproteinase 3 (MMP3) expression without direct binding to MMP3 promoter and increased the 5-hydroxymethylcytosine (5hmC) level at the MMP3 promoter...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220837/a-novel-role-of-the-organizer-gene-goosecoid-as-an-inhibitor-of-wnt-pcp-mediated-convergent-extension-in-xenopus-and-mouse
#2
Bärbel Ulmer, Melanie Tingler, Sabrina Kurz, Markus Maerker, Philipp Andre, Dina Mönch, Marina Campione, Kirsten Deißler, Mark Lewandoski, Thomas Thumberger, Axel Schweickert, Abraham Fainsod, Herbert Steinbeißer, Martin Blum
Goosecoid (Gsc) expression marks the primary embryonic organizer in vertebrates and beyond. While functions have been assigned during later embryogenesis, the role of Gsc in the organizer has remained enigmatic. Using conditional gain-of-function approaches in Xenopus and mouse to maintain Gsc expression in the organizer and along the axial midline, neural tube closure defects (NTDs) arose and dorsal extension was compromised. Both phenotypes represent convergent extension (CE) defects, arising from impaired Wnt/planar cell polarity (PCP) signaling...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220482/morphological-interaction-between-the-nasal-septum-and-nasofacial-skeleton-during-human-ontogeny
#3
Matthew J Goergen, Nathan E Holton, Thorsten Grünheid
The nasal septal cartilage is thought to be a key growth center that contributes to nasofacial skeletal development. Despite the developmental influence of the nasal septum however, humans often exhibit a high frequency of septal deviation suggesting discordance in the growth between the septum and surrounding nasofacial skeleton. While there are numerous etiological factors that contribute to septal deviation, the surrounding nasofacial skeleton may also act to constrain the septum, resulting in altered patterns of growth...
February 20, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28220293/effects-of-bisphosphonates-on-osteogenesis-and-osteoclastogenesis-signaling-during-the-endochondral-ossification-of-growing-rats
#4
Eloiza Rezende, Vivian Bradaschia-Correa, Fabio Siviero, Lucas M B Ambrosio, Victor E Arana-Chavez
Osteoclasts and chondroclasts are necessary, during endochondral ossification, for the resorption of primary bone and calcified cartilage septa, respectively. The bisphosphonates inhibit mineralized tissue resorption by various mechanisms according to the different types of this drug, which can affect bone remodeling during skeletal growth. The objective of the present study is to analyze the way that alendronate (ALN) and etidronate (ETN) can affect osteoclastogenesis and bone formation during endochondral ossification of the long bones of growing rats...
February 20, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28219168/-thyroid-adenoma-in-the-piriform-fossa-a-case-report-and-literature-review
#5
X T Huang, B Ma, M B Liu, Y Zhang, D L Huang, L Chen
Objective: To explore the clinical characteristics of case of thyroid adenoma in the piriform fossa, and review the literatures of the congentital thyroid gland abnormality. Methods: A 44-year-old male had foreign body feeling in his pharynx for 3 years. A mass in his left piriform fossa was detected by the clinical and imaging examination. Biopsy report that the mass was thyroid papillary carcinoma. The resection of tumor with partial back thyroid cartilage through lateral neck and pharyngeal approach was performed...
February 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28218386/glucose-adsorption-to-chitosan-membranes-increases-proliferation-of-human-chondrocyte-via-mammalian-target-of-rapamycin-complex-1-and-sterol-regulatory-element-binding-protein-1-signaling
#6
Shun-Fu Chang, Kuo-Chin Huang, Chin-Chang Cheng, Yu-Ping Su, Ko-Chao Lee, Cheng-Nan Chen, Hsin-I Chang
BACKGROUND: Osteoarthritis (OA) is currently still an irreversible degenerative disease of the articular cartilage. Recent, dextrose (D-glucose) intraarticular injection prolotherapy for OA patients has been reported to benefit the chondrogenic stimulation of damaged cartilage. However, the detailed mechanism of glucose's effect on cartilage repair remains unclear. Chitosan, a naturally derived polysaccharide, has recently been investigated as a surgical or dental dressing to control breeding...
February 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28217617/temporomandibular-joint-ankylosis-in-ankylosing-spondylitis-a-case-report-and-review-of-literature
#7
Nishtha Gupta, Nikhil Gupta, Laxmikant Ramkumarsingh Tomar, Nikhil Nair
Ankylosing spondylitis (AS) is a chronic systemic inflammatory disorder. It primarily affects the axial skeleton through involvement of the peripheral joint scan occurs. Temporomandibular joint (TMJ) involvement in AS varies from 4% to 35%. Here, we present a case of a 35-year-old male, follow-up of AS from last 8 years on nonsteroidal anti-inflammatory drugs, presented with fresh complaints of painfully restricted movements of jaw during swallowing. Computer tomography of patient demonstrates articular cartilage changes with disc and joint abnormalities...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28217270/neurological-assessment-and-nerve-conduction-study-findings-in-22-patients-with-alkaptonuria-from-jordan
#8
Omar Alrawashdeh, Mohammad Alsbou, Hamed Alzoubi, Hani Al-Shagahin
Alkaptonuria is a rare metabolic disease characterised by accumulative deposition of homogentisic acid in the connective tissue of the body. This results in early degeneration of tendons, cartilages, heart valves, and other tissues. The main objective of the study is to examine the possibility of the nervous system involvement in patients with alkaptonuria The sample consists of two groups; 22 patients with AKU and 20 controls. A neurological assessment has been carried out including detailed medical history, neurological examination, and a nerve conduction study of the nerves of the dominant hand...
November 2, 2016: Neurology International
https://www.readbyqxmd.com/read/28216810/nasal-correction-in-nasomaxillary-hypoplasia-binder-s-syndrome-an-optimised-classification-and-treatment
#9
Venkata Ramana Yamani, Shakuntala Ghosh, Shreekumar Tirunagari
BACKGROUND: Nasomaxillary hypoplasia is a rare congenital disorder involving the central face. It imparts a distinctive appearance to the individual face as the age advances. Severity of the disorder varies, so do the manifestations. METHODS: This was a retrospective study conducted on the records and photographic data of 560 rhinoplasty cases performed between 2006 March and 2016 March. About 16 cases of nasomaxillary hypoplasia were selected from the group and they were classified based on the severity of the features...
September 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28216311/meniscal-extrusion-and-bone-marrow-lesions-are-associated-with-incident-and-progressive-knee-osteoarthritis
#10
Andrew J Teichtahl, Flavia M Cicuttini, François Abram, Yuanyuan Wang, Jean-Pierre Pelletier, Pierre Dodin, Johanne Martel-Pelletier
OBJECTIVE: Whether meniscal extrusion and bone marrow lesions (BMLs) are independently associated with the risk of knee osteoarthritis (OA) is unknown. METHODS: Data was extracted from the Osteoarthritis Initiative (OAI) cohort. Participants were grouped according to the absence (Kellgren-Lawrence (KL) grade ≤ 1, n = 2120) or presence (KL ≥ 2, n = 2249) of ROA. Baseline meniscal extrusion and tibial BMLs were assessed. Tibial plateau cartilage volume was assessed at baseline and 72 months, while radiographic disease was assessed at baseline and 48 months...
February 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28216310/adamts-and-adam-metalloproteinases-in-osteoarthritis-looking-beyond-the-usual-suspects
#11
REVIEW
Chun-Yao Yang, Anastasios Chanalaris, Linda Troeberg
INTRODUCTION: Matrix metalloproteinases and 'aggrecanase' ADAMTSs are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix type II collagen and aggrecan, and are thus potential targets for development of OA therapies. OBJECTIVE: This paper aims to provide a comprehensive review of the expression and potential roles of other, lesser-known ADAMTSs and related adamalysins (or ADAMs) in cartilage, with a view to identifying potentially protective or homeostatic metalloproteinases in the joint and informing consequent selective inhibitor design...
February 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28215996/morphological-and-behavioral-responses-of-zebrafish-after-24h-of-ketamine-embryonic-exposure
#12
Luís M Félix, Cindy Serafim, Maria J Martins, Ana M Valentim, Luís M Antunes, Manuela Matos, Ana M Coimbra
Ketamine, one anesthetic used as an illicit drug, has been detected both in freshwater and marine ecosystems. However, knowledge of its impact on aquatic life is still limited. This study aimed to test its effects in zebrafish embryos by analyzing its time- and dose-dependent developmental toxicity and long-term behavioral changes. The 24h-LC50 was calculated from percent survival using probit analysis. Based on the 24h-LC50 (94.4mgL(-1)), embryos (2hour post-fertilization - hpf) were divided into four groups, including control, and exposed for 24h to ketamine concentrations of 50, 70 or 90mgL(-1)...
February 16, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28215523/editorial-for-the-special-issue-on-cartilage-biology-and-pathology
#13
EDITORIAL
Véronique Lefebvre
No abstract text is available yet for this article.
February 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28215089/structure-and-property-changes-in-self-assembled-lubricin-layers-induced-by-calcium-ion-interactions
#14
George W Greene, Rajiv Thapa, Stephen Andrew Holt, Xiaoen Wang, Christopher J Garvey, Rico F Tabor
Lubricin is a "mucin-like" glycoprotein found in synovial fluids and coating the cartilage surfaces of articular joints which is now generally accepted as one of the body's primary boundary lubricants and anti-adhesive agents. Lubricin's superior lubrication and anti-adhesion are believed to derive from its unique interfacial properties by which lubricin molecules adhere to surfaces (and biomolecules, including hyaluronic acid and collagen) through discrete interactions localized to its two terminal end-domains...
February 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28214464/cell-based-treatment-for-the-management-of-articular-cartilage-injuries-where-are-we
#15
William Rossy, Eric Strauss
Articular cartilage is a specialized tissue that lines the surface of joints. Injuries to articular cartilage pose challenges due to poor healing potential. Focal cartilage defects are typically the result of high impact or repetitive loads to the articular surface. They tend to occur in the younger, active population and have been shown to cause swelling, pain, and joint dysfunction. Although the natural history of these lesions has never been definitively elucidated in the literature, clinical experience suggests that if left untreated, these lesions will demonstrate an inability to heal and may lead to prolonged increased articular peak stresses, which in turn may lead to pain and significant limitations in the future...
January 2017: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/28214459/molecular-biomarkers-of-knee-pathology
#16
Vanessa Cuellar, Eric Strauss
The identification of biomarkers has become increasingly important in our fundamental understanding of the molecular basis for disease and subsequently in the advancement of modern medicine. Biomarkers have been identified in a plethora of normal and pathologic conditions and are most often found in blood, tissue, or synovial fluid. Orthopaedic research has more recently focused on biomarkers of cartilage and joint diseases, with an emphasis on understanding the molecular underpinnings of their pathophysiology...
January 2017: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/28214084/il-10-and-tgf-%C3%AE-roles-in-chondroprotective-effects-of-glucosamine-in-experimental-osteoarthritis
#17
Nermien E Waly, Abeer Refaiy, Nora M Aborehab
OBJECTIVE: Osteoarthritis (OA) is a complex disease of the whole joint. Glucosamine (GlcN) treatment may have a chondroprotective effect on OA. We investigated the mechanism of action of glucosamine treatment through interleukin-10 (Il-10) and transforming growth factor β-1 (TGF β-1). METHODS: Thirty male albino rats were used. A single intraarticular (i.a.) injection of 2mg of Monosodium Iodoacetate (MIA) was injected into the knee joint of anesthetized rats...
February 11, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28213953/the-effects-of-acl-graft-placement-on-in-vivo-knee-function-and-cartilage-thickness-distributions
#18
REVIEW
Louis E DeFrate
Injuries to the anterior cruciate ligament (ACL) frequently lead to early-onset osteoarthritis. Despite advancement in surgical techniques, ACL reconstruction has a limited ability to prevent these degenerative changes. While previous studies have investigated knee function after ACL reconstruction, in vivo investigations of the effects of graft placement on in vivo joint function and cartilage health are limited. This review presents a series of studies that used novel imaging and 3D modeling techniques to determine the in vivo placement of the ACL graft on the femur using two different ACL reconstruction techniques...
February 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28213717/the-minor-collagens-in-articular-cartilage
#19
REVIEW
Yunyun Luo, Dovile Sinkeviciute, Yi He, Morten Karsdal, Yves Henrotin, Ali Mobasheri, Patrik Önnerfjord, Anne Bay-Jensen
Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions...
February 17, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28213682/mathematical-modelling-of-cytokines-mmps-and-fibronectin-fragments-in-osteoarthritic-cartilage
#20
Michelle Baker, Bindi S Brook, Markus R Owen
Osteoarthritis (OA) is a degenerative disease which causes pain and stiffness in joints. OA progresses through excessive degradation of joint cartilage, eventually leading to significant joint degeneration and loss of function. Cytokines, a group of cell signalling proteins, present in raised concentrations in OA joints, can be classified into pro-inflammatory and anti-inflammatory groups. They mediate cartilage degradation through several mechanisms, primarily the up-regulation of matrix metalloproteinases (MMPs), a group of collagen-degrading enzymes...
February 17, 2017: Journal of Mathematical Biology
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