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https://www.readbyqxmd.com/read/29232729/-influence-of-synovial-fluid-on-lubrication-of-articular-cartilage-in-vitro-a-review
#1
Steffen Thier, Marcus Tonak
Articular cartilage possesses unique tribological properties that are essential to reduce friction and wear. Especially under boundary lubrication conditions, synovial fluid as a whole, and its components ("biolubricants"), are important in assuring near frictionless/contactless lubrication of the joint surfaces. Therefore, several in vitro tribological models have been developed in recent years to investigate possible interdependencies. The aim of this article is to give a cursory overview of the influence of synovial fluid and its components on boundary lubrication of articular cartilage surfaces in vitro...
December 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29231159/facet-joint-injections-for-non-specific-low-back-pain-a-feasibility-rct
#2
Saowarat Snidvongs, Rod S Taylor, Alia Ahmad, Simon Thomson, Manohar Sharma, Angela Farr, Deborah Fitzsimmons, Stephanie Poulton, Vivek Mehta, Richard Langford
BACKGROUND: Pain of lumbar facet-joint origin is a common cause of low back pain in adults and may lead to chronic pain and disability, with associated health and socioeconomic implications. The socioeconomic burden includes an inability to return to work resulting in loss of productivity in addition to direct and indirect health-care utilisation costs. Lumbar facet-joints are paired synovial joints between the superior and inferior articular processes of consecutive lumbar vertebrae and between the fifth lumbar vertebra and the sacrum...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29231060/combined-effects-of-ovariectomy-and-streptozotocin-induced-diabetes-in-the-articular-cartilage-of-rats
#3
A Saeki Fernandes, C C N Fonseca, G Rodrigues da Silva Sasso, L Carvalho Cezar, M Aparecida Dos Santos, M J Simões, R S Simões, R Florencio-Silva
AIM: To evaluate the combined effects of streptozotocin-induced diabetes (Di) and ovariectomy in the articular cartilage of rats. METHODS: Forty adult female Wistar rats were ovariectomized (OVX) or sham-operated. After recovery from surgery, the animals were assigned randomly into four groups: OVX control (OVX-C); OVX treated with 10 µg/kg/day of 17β-estradiol (OVX-E); sham-operated subjected to Di (Sham-Di); and OVX subjected to Di (OVX-Di). After 60 days of treatment, the animals were euthanized and the distal femurs with articular cartilage were processed for paraffin-embedding...
December 12, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29230995/-individual-identification-of-cartilage-by-direct-amplification-in-mass-disasters
#4
C H Wang, C Xu, X Q Li, Y Wu, Z Du
OBJECTIVES: To explore the effectiveness of direct amplification for the STR analysis of cartilage, and to accelerate the effectiveness of disaster victim identification. METHODS: Eighty-eight cartilage samples were directly amplified by PowerPle® 21 kit, and the results of genotyping were compared with that obtained by the magnetic beads method. RESULTS: In 88 cartilage samples, the STR genotypes were successfully detected from 84 samples by direct amplification and magnetic beads method, and both the results of genotyping by two method were consistent...
June 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29230632/ghrelin-accelerates-the-cartilagic-differentiation-of-rabbit-mesenchymal-stem-cells-through-the-erk1-2-pathway
#5
Nan Ye, Lin Wang, Zhe Dou, Jian Huang
Mesenchymal stem cells (MSCs) can differentiate into chondroblasts, adipocytes, or cartilage under appropriate stimulation. Identifying a mechanism triggering the differentiation of MSCs into cartilage may help develop novel therapeutic approaches for treating heterotopic ossification, the pathological formation of lamellar bone in soft tissue outside the skeleton that can lead to debilitating immobility. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, stimulates growth hormone secretion, and has both orexigenic and adipogenic effects...
December 12, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29230383/solitary-extramedullary-plasmacytoma-of-the-cricoid-cartilage-case-report
#6
Simone Krebs, Ian Ganly, Ronald Ghossein, Joanna Yang, Joachim Yahalom, Heiko Schöder
Solitary plasmacytoma (SP) is an extremely rare form of hematologic malignancy that can be classified as solitary bone plasmacytoma or solitary extramedullary plasmacytoma. Here, we report a patient who presented with progressive shortness of breath and foreign body sensation in his throat. Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) demonstrated an abnormal FDG-avid soft tissue mass arising from the larynx involving the cricoid cartilage without additional suspicious lesions...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29230269/extracellular-vesicles-from-adipose-derived-mesenchymal-stem-cells-downregulate-senescence-features-in-osteoarthritic-osteoblasts
#7
Miguel Tofiño-Vian, Maria Isabel Guillén, María Dolores Pérez Del Caz, Miguel Angel Castejón, Maria José Alcaraz
Osteoarthritis (OA) affects all articular tissues leading to pain and disability. The dysregulation of bone metabolism may contribute to the progression of this condition. Adipose-derived mesenchymal stem cells (ASC) are attractive candidates in the search of novel strategies for OA treatment and exert anti-inflammatory and cytoprotective effects on cartilage. Chronic inflammation in OA is a relevant factor in the development of cellular senescence and joint degradation. In this study, we extend our previous observations of ASC paracrine effects to study the influence of conditioned medium and extracellular vesicles from ASC on senescence induced by inflammatory stress in OA osteoblasts...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29229562/electromechanical-properties-of-human-osteoarthritic-and-asymptomatic-articular-cartilage-are-sensitive-and-early-detectors-of-degeneration
#8
I Hadjab, S Sim, S S Karhula, S Kauppinen, M Garon, E Quenneville, P Lavigne, P P Lehenkari, S Saarakkala, M D Buschmann
OBJECTIVE: To evaluate cross-correlations of ex vivo electromechanical properties with cartilage and subchondral bone plate thickness, as well as their sensitivity and specificity regarding early cartilage degeneration in human tibial plateau. METHOD: Six pairs of tibial plateaus were assessed ex vivo using an electromechanical probe (Arthro-BST) which measures a quantitative parameter (QP) reflecting articular cartilage compression-induced streaming potentials...
December 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29229415/return-to-sports-after-tibial-tubercle-osteotomy-for-patellofemoral-pain-and-osteoarthritis
#9
Joseph N Liu, Hao-Hua Wu, Grant H Garcia, Irene L Kalbian, Sabrina M Strickland, Beth E Shubin Stein
PURPOSE: To determine the rate of return to sports and clinical outcomes after anteromedialization (AMZ) tibial tubercle osteotomy (TTO) for patients with patellofemoral pain and/or osteoarthritis. METHODS: This study is a retrospective case series of consecutive patients who underwent unilateral or staged bilateral AMZ TTO for a primary diagnosis of patellofemoral pain or arthritis. Included were all patients with minimum 1-year follow-up. The indication for surgery was failure of at least 6 months of nonoperative treatment...
December 8, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29229399/the-malleus-cap-anatomic-description-of-cartilage-of-the-lateral-process-of-the-malleus
#10
Elias Michaelides, Ankit Kansal, Sara Rutter, Christopher A Schutt
PURPOSE: To anatomically describe a cartilaginous cap attached to the lateral process of the malleus. STUDY DESIGN: Histologic and gross anatomic review. METHODS: Twenty temporal bones were histologically reviewed. The anatomical relationship between the tympanic membrane and malleus was then defined at the level of the lateral process of the malleus and the long process of the malleus. Separately, gross evaluation of these levels at the macroscopic level was undertaken through endoscopic imaging in five subjects...
October 25, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29229348/bone-morphogenetic-proteins-usage-in-anterior-lumbar-inter-body-fusion-what-else-can-go-wrong
#11
Elias Elias, Zeina Nasser, Lona Winegan, Terence Verla, Ibrahim Omeis
BACKGROUND: Bone Morphogenetic Protein (BMP) graft showed promising outcome during early phases of its use. However unreported adverse events and off label use shattered its safe profile and raised concerns regarding its indication. In 2008, the Food and Drug Administration (FDA) prohibited its use in anterior cervical spine procedures due to possibility of edema, hematoma and need of intubation. At the molecular level, BMP act as multifactorial growth factors playing a role in cartilage, heart, and bone formation...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29229249/enzyme-mediated-tissue-adhesive-hydrogels-for-meniscus-repair
#12
Su-Hwan Kim, Young-Hyeon An, Hwan D Kim, Kyungmin Kim, Sang-Hyuk Lee, Hyun-Gu Yim, Byung-Gee Kim, Nathaniel S Hwang
Meniscus tissues have limited regenerative capacity once damaged. The treatment options for the meniscus tissue regeneration have been limited to arthroscopic meniscectomy or surgical interventions. The injectable hydrogels based system would provide an alternative to the conventional meniscus therapy by providing a minimally invasive treatment alternative. Here we utilized enzyme-based approaches to fabricate tissue adhesive hydrogels for meniscus repair. Tyramine (TA) conjugated hyaluronic acid (TA-HA) and gelatin are susceptible to tyrosinase (TYR)-mediated crosslinking in vitro and in vivo...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29229239/in-vivo-postoperative-motion-analysis-of-metal-and-ceramic-bipolar-hip-hemiarthroplasty
#13
Toru Yoshioka, Nobukazu Okimoto, Yoshifumi Fuse, Makoto Kawasaki, Toshiharu Mori, Akinori Sakai, Tokifumi Majima
BACKGROUND: We hypothesized that ceramic bipolar shows less impingement between stem neck and outer head compared to metal bipolar, because of its low coefficient of friction with the acetabulum cartilage. In this paper, a three dimensional (3D) postoperative motion analysis has been used to assess the different motion characteristics of metal and ceramic bipolar hip hemiarthroplasty systems. METHODS: This study was conducted on 40 patients divided in two matched cohorts: 20 patients with metal bipolar and 20 patients with the ceramic bipolar...
December 8, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29228690/cartilage-oligomeric-matrix-protein-promotes-prostate-cancer-progression-by-enhancing-invasion-and-disrupting-intracellular-calcium-homeostasis
#14
Emelie Englund, Giacomo Canesin, Konstantinos S Papadakos, Neelanjan Vishnu, Emma Persson, Bart Reitsma, Aseem Anand, Laila Jacobsson, Leszek Helczynski, Hindrik Mulder, Anders Bjartell, Anna M Blom
Cartilage oligomeric matrix protein (COMP) was recently implicated in the progression of breast cancer. Immunostaining of 342 prostate cancer specimens in tissue microarrays showed that COMP expression is not breast cancer-specific but also occurs in prostate cancer. The expression of COMP in prostate cancer cells correlated with a more aggressive disease with faster recurrence. Subcutaneous xenografts in immunodeficient mice showed that the prostate cancer cell line DU145 overexpressing COMP formed larger tumors in vivo as compared to mock-transfected cells...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228639/role-of-melatonin-combined-with-exercise-as-a-switch-like-regulator-for-circadian-behavior-in-advanced-osteoarthritic-knee
#15
Yunkyung Hong, Hyunsoo Kim, Seunghoon Lee, Yunho Jin, Jeonghyun Choi, Sang-Rae Lee, Kyu-Tae Chang, Yonggeun Hong
Here, we show the role of melatonin combined with or without exercise as a determinant of multicellular behavior in osteoarthritis. We address the relationship between the molecular components governing local circadian clock and changes in the osteoarthritic musculoskeletal axis. Melatonin was injected subcutaneously in animals with advanced knee osteoarthritis (OA) for 4 weeks. Concurrently, moderate treadmill exercise was applied for 30 min/day. Morphometric, histological, and gene/protein-level analyses were performed in the cartilage, synovium, bone, and gastrocnemius muscle...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228600/non-invasive-in-vivo-molecular-imaging-of-intra-articularly-transplanted-immortalized-bone-marrow-stem-cells-for-osteoarthritis-treatment
#16
Bou-Yue Peng, Chi-Sheng Chiou, Navneet Kumar Dubey, Sung-Hsun Yu, Yue-Hua Deng, Feng-Chou Tsai, Han-Sun Chiang, Ying-Hua Shieh, Wei-Hong Chen, Win-Ping Deng
Pathophysiology of osteoarthritis (OA) is characterized by progressive loss of articular cartilage in the knee-joints. To impart regenerative ability in lowly metabolizing chondrocytes, the bone marrow stem cells (BMSCs) has recently been recognized as a superior alternative treatment for OA. However, study of primary BMSCs-mediated chondrogenesis is difficult due to progressive cellular aging and replicative senescence. To obtain a therapeutic cell population for OA, BMSCs were immortalized by human papilloma virus (HPV)-16 E6/E7 along with mCherry luciferase (mCL), a gene marker for non-invasive imaging, and designated as iBMSCs-mCL...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228594/bone-strengthening-pill-bsp-promotes-bone-cell-and-chondrocyte-repair-and-the-clinical-and-experimental-study-of-bsp-in-the-treatment-of-osteonecrosis-of-the-femoral-head
#17
Zheng Li, Lulin Wang, Jin Wei, Liguo Zhu, Xisheng Weng, Jin Jin, Hong Xiao, Jun Zhang, Heming Wang, Guantong Shi, Lingpeng Pei, Fangde Zou, Wanqiang Zhang, Tianzun Tao, Xin Dong
About 1 in 3 people suffer from bone and joint disease, which is a disease of bone and cartilage cells. Osteonecrosis of the femoral head (ONFH) is a typical example of bone and joint disease involving bone cell necrosis. Osteonecrosis of the femoral head leads to the occurrence of premature osteoarthritis of the hip and collapse of the cartilage cells, and there is currently no effective drug treatment available. In order to study the effects of "bone-strengthening pill" (BSP) on the repair of bone and cartilage cells, we investigated the potential effects of the herbal mixture BSP in an animal model of avascular necrosis of the femoral head and in patients...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227579/obesity-type-2-diabetes-increases-inflammation-periosteal-reactive-bone-formation-and-osteolysis-during-staphylococcus-aureus-implant-associated-bone-infection
#18
Christopher W Farnsworth, Eric M Schott, Abigail M Benvie, Jacob Zukoski, Stephen L Kates, Edward M Schwarz, Steven R Gill, Michael J Zuscik, Robert A Mooney
Obese and type 2 diabetic (T2D) patients have a 5-fold increased rate of infection following placement of an indwelling orthopaedic device. Though implant infections are associated with inflammation, periosteal reactive bone formation and osteolysis, the effect of obesity/T2D on these complicating factors has not been studied. To address this question, C57BL/6J mice were fed a high fat diet (60% Kcal from fat) to induce obesity/T2D, or a control diet (10% Kcal from fat) for three months, and challenged with a transtibial pin coated with a bioluminescent USA300 strain of S...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29227451/cartilage-conduction-hearing-aids-for-severe-conduction-hearing-loss
#19
Tadashi Nishimura, Hiroshi Hosoi, Osamu Saito, Ryota Shimokura, Toshiaki Yamanaka, Tadashi Kitahara
OBJECTIVE: To assess the benefits of a new type of hearing aid using cartilage conduction (CC) in patients with severe conduction hearing loss and evaluate its potential for practical use. STUDY DESIGN: Consecutive, prospective case series. PATIENTS: Forty-one subjects (21 with bilateral aural atresia; 15 with unilateral aural atresia; and 5 others) participated in this study. INTERVENTION: Fitting and gain adjustments of the CC hearing aids were performed to the ear(s) with conduction hearing loss...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29227373/incidence-of-meniscal-entrapment-and-associated-knee-injuries-in-tibial-spine-avulsions
#20
Jason T Rhodes, Peter C Cannamela, Aristides I Cruz, Meredith Mayo, Alexandra C Styhl, Connor G Richmond, Theodore J Ganley, Kevin G Shea
BACKGROUND: Tibial spine avulsions (TSA) have historically been treated as isolated injuries. Data on associated injuries are limited with existing literature reporting wide ranging incidences. The purpose of this multicenter study was to (1) describe the incidence of meniscal entrapment and associated knee injuries in TSA and to (2) compare surgical and magnetic resonance image (MRI) findings for these injuries. Our hypothesis is that tibial spine injuries are not usually isolated injuries, and other meniscal, ligament, and cartilage injuries may be present...
December 8, 2017: Journal of Pediatric Orthopedics
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