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Autoantibodies paraneoplatic pemphigus

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https://www.readbyqxmd.com/read/24604965/follicular-dendritic-cell-sarcoma-with-paraneoplatic-pemphigus-rare-case-and-a-brief-review-of-literature
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Saphalta Baghmar, Sanjeev Kumar, S Dutta Gupta, Vinod Raina
Paraneoplastic pemphigus (PNP) is often a fatal autoimmune bullous disease characterized by severe stomatitis, polymorphous skin eruptions, and underlying neoplasms. We describe a patient with PNP associated with follicular dendritic cell sarcoma (FDCS), a rare neoplasm originating from follicular dendritic cells, which are non-lymphoid, non-phagocytic accessory cells of the lymphoid system and play an integral role in regulation of the germinal center reaction and present antigens to B-cells. The presence of rich vascularity around the tumor and few hyalanized vascular follicles found in histopathological examination gives the clue that the tumor might have developed from Castleman's disease (CD)...
October 2013: Indian Journal of Medical and Paediatric Oncology
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