Juan Chen, Shenghui Zhang, Yao You, Siqi Hu, Jiake Tang, Chen Chen, Wen Wen, Ting Tang, Qingwen Yu, Xuhan Tong, Chunyi Wang, Wenbin Zhao, Xinyan Fu, Xingwei Zhang, Mingwei Wang, Wenyan Gong
BACKGROUND: Diabetic retinopathy (DR) frequently results in compromised visual function, with hyperglycemia-induced disruption of the blood-retinal barrier (BRB) through various pathways as a critical mechanism. Existing DR treatments fail to address early and potentially reversible microvascular alterations. This study examined the effects of empagliflozin (EMPA), a selective Sodium-glucose transporter 2 (SGLT2) inhibitor, on the retina of db/db mice. The objective of this study is to investigate the potential role of EMPA in the prevention and delay of DR...
April 23, 2024: European Journal of Ophthalmology