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JOURNAL ARTICLE
Caishan Yan, Dongshi Guan, Yin Wang, Pik-Yin Lai, Hsuan-Yi Chen, Penger Tong
We report direct atomic force microscopy measurements of pinning-depinning dynamics of a circular moving contact line (CL) over the rough surface of a micron-sized vertical hanging glass fiber, which intersects a liquid-air interface. The measured capillary force acting on the CL exhibits sawtoothlike fluctuations, with a linear accumulation of force of slope k (stick) followed by a sharp release of force δf, which is proportional to the CL slip length. From a thorough analysis of a large volume of the stick-slip events, we find that the local maximal force F_{c} needed for CL depinning follows the extreme value statistics and the measured δf follows the avalanche dynamics with a power law distribution in good agreement with the Alessandro-Beatrice-Bertotti-Montorsi (ABBM) model...
February 23, 2024: Physical Review Letters
#22
JOURNAL ARTICLE
Giancarlo Marra, Stefano Tappero, Francesco Barletta, Alessandro Marquis, Marco Allasia, Marco Oderda, Charles Dariane, Marc-Olivier Timsit, Julien Branchereau, Benoit Mesnard, Derya Tilki, Jonathon Olsburgh, Meghana Kulkarni, Veeru Kasivisvanathan, Cedric Lebacle, Alberto Breda, Antonio Galfano, Giorgio Gandaglia, Alberto Briganti, Francesco Montorsi, Luigi Biancone, Paolo Gontero
BACKGROUND AND OBJECTIVE: It is unknown whether renal transplant receipt (RTR) status can affect perioperative and oncological outcomes of radical prostatectomy (RP). Our aim was to evaluate oncological and functional outcomes of RTR patients treated with RP for cN0M0 prostate cancer (PCa) via comparison with a no-RTR cohort. METHODS: RTR patients who had undergone RP at seven European institutions during 2001-2022 were identified. A multi-institutional cohort of no-RTR patients treated with RP during 2004-2022 served as the comparator group...
March 6, 2024: European Urology Focus
#23
JOURNAL ARTICLE
Fausto Negri, Luca Boeri, Simone Cilio, Edoardo Pozzi, Federico Belladelli, Christian Corsini, Massimiliano Raffo, Giuseppe Fallara, Eugenio Ventimiglia, Luigi Candela, Alessia d'Arma, Francesco Montorsi, Andrea Salonia
PURPOSE: We aimed to investigate the relationship between follicle stimulating hormone (FSH) and inhibin B (InhB). MATERIALS AND METHODS: Data from 1,230 consecutive men presenting for primary couple's infertility were analyzed. Health-significant comorbidities were scored with Charlson comorbidity index. Quartiles of FSH and InhB were considered to determine threshold values. Descriptive statistics and logistic regression models tested association between FSH and InhB values...
February 29, 2024: World Journal of Men's Health
#24
JOURNAL ARTICLE
Celeste Manfredi, Antonio Franco, Francesco Ditonno, Raman Mathur, Giorgio Franco, Riccardo Lombardo, Giorgio I Russo, Sabrina DE Cillis, Cristian Fiori, Davide Arcaniolo, Alessandro Antonelli, Riccardo Autorino, Marco DE Sio, Cosimo DE Nunzio
INTRODUCTION: Patients' treatment preferences (PTP) depend on the complex interaction of numerous patient- and treatment-related factors; their assessment can guide therapy and promote compliance of patients with erectile dysfunction (ED). We aimed to systematically describe the literature evaluating the treatment preferences of patients with ED, published in the last 25 years. EVIDENCE ACQUISITION: A comprehensive bibliographic search of multiple databases was conducted in June, 2023...
February 2024: Minerva urology and nephrology
#25
JOURNAL ARTICLE
Ugo Boggi, Emanuele Kauffmann, Niccolò Napoli, S George Barreto, Marc G Besselink, Giuseppe K Fusai, Thilo Hackert, Mohammad Abu Hilal, Giovanni Marchegiani, Roberto Salvia, Shailesh Shrikhande, Mark Truty, Jens Werner, Christopher Wolfgang, Elisa Bannone, Giovanni Capretti, Alice Cattelani, Alessandro Coppola, Alessandro Cucchetti, Davide De Sio, Armando Di Dato, Giovanna Di Meo, Claudio Fiorillo, Cesare Gianfaldoni, Michael Ginesini, Camila Hidalgo Salinas, Quirino Lai, Mario Miccoli, Roberto Montorsi, Michele Pagnanelli, Andrea Poli, Claudio Ricci, Francesco Sucameli, Domenico Tamburrino, Virginia Viti, Pietro F Addeo, Sergio Alfieri, Philippe Bachellier, Gianluca Baiocchi, Gianpaolo Balzano, Linda Barbarello, Alberto Brolese, Juli Busquets, Giovanni Butturini, Fabio Caniglia, Damiano Caputo, Riccardo Casadei, Xi Chunhua, Ettore Colangelo, Andrea Coratti, Francesca Costa, Francesco Crafa, Raffaele Dalla Valle, Luciano De Carlis, Roeland F de Wilde, Marco Del Chiaro, Fabrizio Di Benedetto, Pierluigi Di Sebastiano, Safi Domak, Melissa Hogg, Vyacheslav I Egorov, Giorgio Ercolani, Giuseppe Maria Ettorre, Massimo Falconi, Giovanni Ferrari, Alessandro Ferrero, Marco Filauro, Alessandro Giardino, Gian Luca Grazi, Salvatore Gruttaduaria, Jakob R Izbicki, Elio Jovine, Matthew Katz, Tobias Keck, Igor Khatkov, Gozo Kiguchi, David Kooby, Hauke Lang, Carlo Lombardo, Giuseppe Malleo, Marco Massani, Vincenzo Mazzaferro, Riccardo Memeo, Yi Miao, Kohei Mishima, Carlo Molino, Yuichi Nagakawa, Masafumi Nakamura, Bruno Nardo, Fabrizio Panaro, Claudio Pasquali, Vittorio Perrone, Elena Rangelova, Long Riu, Renato Romagnoli, Raffaele Romito, Edoardo Rosso, Richard Schulick, Ajith Siriwardena, Marcello Spampinato, Oliver Strobel, Mario Testini, Roberto Troisi, Faik G Uzunoglo, Roberto Valente, Luigi Veneroni, Alessandro Zerbi, Emilio Vicente, Fabio Vistoli, Marco Vivarelli, Go Wakabayashi, Giacomo Zanus, Amer Zureikat, Nicholas J Zyromski, Roberto Coppola, Vito D'Andrea, José Davide, Christos Dervenis, Isabella Frigerio, Kevin C Konlon, Fabrizio Michelassi, Marco Montorsi, William Nealon, Nazario Portolani, Donzília Sousa Silva, Giuseppe Bozzi, Viviana Ferrari, Maria G Trivella, John Cameron, Pierre-Alain Clavien, Horacio J Asbun
OBJECTIVE: The REDISCOVER consensus conference aimed at developing and validate guidelines on the perioperative care of patients with borderline resectable (BR-) and locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). SUMMARY BACKGROUND DATA: Coupled with improvements in chemotherapy and radiation, the contemporary approach to pancreatic surgery supports resection of BR-PDAC and, to a lesser extent, LA-PDAC. Guidelines outlining the selection and perioperative care for these patients are lacking...
February 26, 2024: Annals of Surgery
#26
JOURNAL ARTICLE
Antony A Pellegrino, Ruben Sauer Calvo, Francesco Pellegrino, Luca Morgantini, Alberto Briganti, Francesco Montorsi, Simone Crivellaro
INTRODUCTION: The da Vinci Single Port (SP) robotic surgical system has minimized the impact of surgery on patients. Hence, outpatient robotic procedures are being explored to reduce costs and improve patient experience. Here, we evaluate the perioperative outcomes and safety of same-day discharge (SDD) after surgery compared to inpatient procedures using the SP. METHODS: A total of 374 patients underwent surgery with the da Vinci SP system between January 2019 and February 2023...
March 2024: Urology Practice
#27
JOURNAL ARTICLE
Marco Moschini, Andrea Necchi, Francesco Montorsi
No abstract text is available yet for this article.
February 17, 2024: European Urology
#28
JOURNAL ARTICLE
Giuseppe Chiarelli, Matthew Davis, Alex Stephens, Giuseppe Ottone Cirulli, Marco Finati, Nicholas J Corsi, Akshay Sood, Shane Tinsley, Giuseppe Carrieri, Alberto Briganti, Francesco Montorsi, Giovanni Lughezzani, Nicolò Buffi, Craig Rogers, Firas Abdollah
OBJECTIVES: To analyze the generalizability of the Göteborg-2 findings to a North American cohort. METHODS: We replicated the Göteborg-2 inclusion criteria in our Henry Ford Health (HFH) cohort, by identifying all patients 50-60 years old who had a PSA test from 2013 to 2018. The first PSA within the study period was considered PSA at entry, and included in the analysis. Chi-square test was used to compare categorical variables between the Göteborg-2 and HFH cohort, with a particular focus on Black men, who were also analyzed separately...
February 9, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
#29
JOURNAL ARTICLE
Giampaolo Perri, Elisa Romandini, Giovanni Marchegiani, Poya Ghorbani, Musheg Sahakyan, Marcus Holmberg, Alice Cattelani, Åsmund Fretland, Roberto Montorsi, Isabella D Rodrigues, Dyre Kleive, Elisa Bannone, Bjørn Edwin, Stefan Gilg, Knut Labori, Ernesto Sparrelid, Roberto Salvia
OBJECTIVES: The aim of this international multicentric study is to characterize postoperative hyperamylasemia (POH) after distal pancreatectomy (DP), with particular focus on its relationship with postoperative pancreatic fistula (POPF) occurrence and severity. BACKGROUND: The clinical relevance of POH after DP and its relationship with the occurrence and severity of POPF have not been explored yet. METHODS: All patients undergoing DP for any indication between 2015 and 2021 at three European referral Centers for pancreatic surgery were retrospectively analyzed...
February 2, 2024: Annals of Surgery
#30
JOURNAL ARTICLE
Roger Li, Luigi Nocera, Kyle M Rose, Daniele Raggi, Shreyas Naidu, Chiara Mercinelli, Antonio Cigliola, Valentina Tateo, Damiano Patanè, G Daniel Grass, Scott M Gilbert, Wade J Sexton, Marco Bandini, Marco Moschini, Alberto Briganti, Francesco Montorsi, Philippe E Spiess, Andrea Necchi
BACKGROUND: Recent progresses in the use of immune checkpoint inhibitor (ICI) have challenged the therapeutic standards in patients with muscle-invasive urothelial bladder carcinoma (MIBC). OBJECTIVE: To compare neoadjuvant pembrolizumab followed by radical cystectomy (RC) versus neoadjuvant chemotherapy (NAC) and RC or upfront RC, according to cisplatin eligibility. DESIGN, SETTING, AND PARTICIPANTS: We conducted two separate analyses for cisplatin-eligible and cisplatin-ineligible cT2-4N0M0 MIBC patients...
January 5, 2024: European Urology Oncology
#31
Giuseppe Fallara, Edoardo Pozzi, Federico Belladelli, Luca Boeri, Paolo Capogrosso, Giovanni Corona, Alessia D'Arma, Massimo Alfano, Francesco Montorsi, Andrea Salonia
No abstract text is available yet for this article.
January 5, 2024: European Urology Focus
#32
JOURNAL ARTICLE
Filippo Pederzoli, Michela Riba, Chiara Venegoni, Laura Marandino, Marco Bandini, Elisa Alchera, Irene Locatelli, Daniele Raggi, Patrizia Giannatempo, Paolo Provero, Dejan Lazarevic, Marco Moschini, Roberta Lucianò, Andrea Gallina, Alberto Briganti, Francesco Montorsi, Andrea Salonia, Andrea Necchi, Massimo Alfano
Neoadjuvant pembrolizumab has been shown to be a valid treatment for patients affected by muscle-invasive bladder cancer (MIBC), as demonstrated in the PURE-01 clinical trial (NCT02736266). Among the tumor-extrinsic factors influencing immunotherapy efficacy, extensive data highlighted that the microbiome is a central player in immune-mediated anticancer activity. This report aimed to investigate the composition and role of stool microbiome in patients enrolled in the PURE-01 clinical trial. An orthotopic animal model of bladder cancer (MB49-Luc) was used to support some of the findings from human data...
January 5, 2024: European Urology
#33
JOURNAL ARTICLE
Simone Cilio, Giuseppe Fallara, Maria Teresa Lupo Stanghellini, Fabio Ciceri, Francesco Montorsi, Francesca Lunghi, Andrea Salonia
PURPOSE: Hydroxyurea (HU) is a cytoreductive agent used as standard treatment option for sickle cell anaemia/disease (SCD), essential thrombocythemia (ET), and polycythaemia vera (PV). Despite its overall good safety profile, its use also in relatively young patients raises an interest on its potential impact on spermatogenesis. To perform a systematic review of all published articles investigating fertility in male patients affected by SCD, ET, and PV and treated with HU. Two paradigmatic case reports of patients affected by PV and ET, respectively, have been also reported...
January 2, 2024: World Journal of Men's Health
#34
JOURNAL ARTICLE
Roberto Maria Montorsi, Sofia Xenaki, Sebastiaan Festen, Paul Fockens, Barbara A J Bastiaansen, Freek Daams, Olivier R Busch, M G Besselink
Duodenal stenosis is a condition that can be related to several diseases, being either intrinsic, such as neoplasm and inflammatory stenosis, or extrinsic, such as pancreatic pseudocyst, superior mesenteric artery syndrome, and foreign bodies. Current treatments range from endoscopic approaches, such as endoscopic resection and stent placement, to surgical approaches, including duodenal resection, pancreaticoduodenectomy, and gastrointestinal bypass. Minimally invasive robot-assisted surgery is gaining importance due to its potential to decrease surgical stress, intraoperative blood loss, and postoperative pain, while its instruments and 3D-vision facilitate fine dissection and intra-abdominal suturing, all leading to a reduced time to functional recovery and shorter hospital stay...
December 15, 2023: Journal of Visualized Experiments: JoVE
#35
JOURNAL ARTICLE
Giancarlo Marra, Pawel Rajwa, Claudia Filippini, Guillaume Ploussard, Gabriele Montefusco, Ignacio Puche-Sanz, Jonathan Olivier, Fabio Zattoni, Fabrizio Dal Moro, Alessandro Magli, Charles Dariane, Andres Affentranger, Josias Bastian Grogg, Thomas Hermanns, Peter K Chiu, Bartosz Malkiewicz, Kamil Kowalczyk, Roderick C N Van den Bergh, Shahrokh F Shariat, Alberto Bianchi, Alessandro Antonelli, Sebastian Gallina, William Berchiche, Rafael Sanchez-Salas, Xavier Cathelineau, Luca Afferi, Christian Daniel Fankhauser, Agostino Mattei, Robert Jeffrey Karnes, Simone Scuderi, Francesco Montorsi, Alberto Briganti, Désirée Deandreis, Paolo Gontero, Giorgio Gandaglia
CONTEXT: Despite negative preoperative conventional imaging, up to 10% of patients with prostate cancer (PCa) harbor lymph-node involvement (LNI) at radical prostatectomy (RP). The advent of more accurate imaging modalities such as PET/CT improved the detection of LNI. However, their clinical impact and prognostic value are still unclear. We aimed to investigate the prognostic value of preoperative PET/CT in patients node positive (pN+) at RP. EVIDENCE SYNTHESIS: We retrospectively identified cN0M0 patients at conventional imaging (CT and/or MRI, and bone scan) who had pN+ PCa at RP at 17 referral centers...
November 17, 2023: Clinical Genitourinary Cancer
#36
JOURNAL ARTICLE
Francesco Pellegrino, Ugo Giovanni Falagario, Sophie Knipper, Alberto Martini, Olof Akre, Lars Egevad, Markus Aly, Marcio Covas Moschovas, Carlo Andrea Bravi, Joshua Tran, Yasmin Heiniger, Antonius von Kempis, Robin Schaffar, Giuseppe Carrieri, Alberto Briganti, Francesco Montorsi, Charles-Henry Rochat, Alexandre Mottrie, Thomas E Ahlering, Hubert John, Vipul Patel, Markus Graefen, Peter Wiklund
BACKGROUND: Positive surgical margins (PSMs) are frequent in patients undergoing radical prostatectomy (RP). The impact of PSMs on cancer-specific (CSM) and overall (OM) mortality has not yet been proved definitively. OBJECTIVE: To evaluate whether the presence and the features of PSMs were associated with CSM and OM in patients who underwent robotic-assisted RP. DESIGN, SETTING, AND PARTICIPANTS: A cohort of 8141 patients underwent robotic-assisted RP with >10 yr of follow-up...
December 27, 2023: European Urology Oncology
#37
JOURNAL ARTICLE
Francesco Pellegrino, Armando Stabile, Gabriele Sorce, Elio Mazzone, Donato Cannoletta, Giuseppe Ottone Cirulli, Leonardo Quarta, Riccardo Leni, Daniele Robesti, Giorgio Brembilla, Giorgio Gandaglia, Francesco De Cobelli, Francesco Montorsi, Alberto Briganti
BACKGROUND: To assess the variation of multiparametric magnetic resonance imaging (mpMRI) positive predictive value (PPV) according to each patient's risk of clinically significant prostate cancer (csPCa) based exclusively on clinical factors. METHODS: We evaluated 999 patients with positive mpMRI (PI-RADS ≥ 3) receiving targeted (TBx) plus systematic prostate biopsy. We built a multivariable logistic regression analysis (MVA) using clinical risk factors to calculate the individual patients' risk of harboring csPCa at TBx...
December 27, 2023: Prostate
#38
REVIEW
Advanced Nanomaterials as Microglia Modulators in the Treatment of Central Nervous System Disorders.
Matteo Battaglini, Attilio Marino, Margherita Montorsi, Alessio Carmignani, Maria Cristina Ceccarelli, Gianni Ciofani
Microglia play a pivotal role in the central nervous system (CNS) homeostasis, acting as housekeepers and defenders of the surrounding environment. These cells can elicit their functions by shifting into two main phenotypes: pro-inflammatory classical phenotype, M1, and anti-inflammatory alternative phenotype, M2. Despite their pivotal role in CNS homeostasis, microglia phenotypes can influence the development and progression of several CNS disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, ischemic stroke, traumatic brain injuries, and even brain cancer...
December 19, 2023: Advanced Healthcare Materials
#39
JOURNAL ARTICLE
Francesco Segatta, Daniel Aranda, Flavia Aleotti, Francesco Montorsi, Shaul Mukamel, Marco Garavelli, Fabrizio Santoro, Artur Nenov
Expressions for linear and nonlinear spectroscopy simulation in the X-ray window in which the time evolution of a photoexcited molecular system is treated via quantum dynamics are derived. By leveraging on the peculiar properties of core-excited/ionized states, first- and third-order response functions are recast in the limit of time-scale separation between the extremely short core-state lifetime and the (comparably longer) electronic-state transfer and nuclear vibrational motion. This work is a natural extension of Segatta et al...
December 15, 2023: Journal of Chemical Theory and Computation
#40
JOURNAL ARTICLE
Giuseppe Ottone Cirulli, Nicholas Corsi, Ivan Rakic, Alex Stephens, Giuseppe Chiarelli, Marco Finati, Matthew Davis, Shane Tinsley, Akshay Sood, Nicolò Buffi, Giovanni Lughezzani, Giuseppe Carrieri, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Craig Rogers, Firas Abdollah
OBJECTIVES: To assess the prognostic ability of LVI in UTUC as a predictor of overall survival (OS) using a large North American cohort. MATERIAL AND METHODS: Our cohort included 5,940 cM0 UTUC patients who underwent a radical nephroureterectomy (RNU), between 2010 and 2016, within the National Cancer Database (NCDB). The main variable of interest was LVI status, and its interaction with pathological nodal (pN) status. Kaplan-Meier curves were used to depict the OS also stratifying patients on LVI status...
December 14, 2023: BJU International
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