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https://www.readbyqxmd.com/read/29784191/outcomes-of-robot-assisted-partial-nephrectomy-for-clinical-t2-renal-tumors-a-multicenter-analysis-rosula-collaborative-group
#1
Riccardo Bertolo, Riccardo Autorino, Giuseppe Simone, Ithaar Derweesh, Juan D Garisto, Andrea Minervini, Daniel Eun, Sisto Perdona, James Porter, Koon Ho Rha, Alexander Mottrie, Wesley M White, Luigi Schips, Bo Yang, Kenneth Jacobsohn, Robert G Uzzo, Ben Challacombe, Matteo Ferro, Jay Sulek, Umberto Capitanio, Uzoma A Anele, Gabriele Tuderti, Manuela Costantini, Stephen Ryan, Ahmet Bindayi, Andrea Mari, Marco Carini, Aryeh Keehn, Giuseppe Quarto, Michael Liao, Kidon Chang, Alessandro Larcher, Geert De Naeyer, Ottavio De Cobelli, Francesco Berardinelli, Chao Zhang, Peter Langenstroer, Alexander Kutikov, David Chen, Nicolo De Luyk, Chandru P Sundaram, Francesco Montorsi, Robert J Stein, Georges Pascal Haber, Lance J Hampton, Prokar Dasgupta, Michele Gallucci, Jihad Kaouk, Francesco Porpiglia
BACKGROUND: While partial nephrectomy (PN) represents the standard surgical management for cT1 renal masses, its role for cT2 tumors is controversial. Robot-assisted PN (RAPN) is being increasingly implemented worldwide. OBJECTIVE: To analyze perioperative, functional, and oncological outcomes of RAPN for cT2 tumors. DESIGN, SETTING, AND PARTICIPANTS: Retrospective analysis of a large multicenter, multinational dataset of patients with nonmetastatic cT2 masses treated with robotic surgery (ROSULA: RObotic SUrgery for LArge renal mass)...
May 18, 2018: European Urology
https://www.readbyqxmd.com/read/29778349/a-contemporary-prostate-biopsy-risk-calculator-based-on-multiple-heterogeneous-cohorts
#2
Donna P Ankerst, Johanna Straubinger, Katharina Selig, Lourdes Guerrios, Amanda De Hoedt, Javier Hernandez, Michael A Liss, Robin J Leach, Stephen J Freedland, Michael W Kattan, Robert Nam, Alexander Haese, Francesco Montorsi, Stephen A Boorjian, Matthew R Cooperberg, Cedric Poyet, Emily Vertosick, Andrew J Vickers
BACKGROUND: Prostate cancer prediction tools provide quantitative guidance for doctor-patient decision-making regarding biopsy. The widely used online Prostate Cancer Prevention Trial Risk Calculator (PCPTRC) utilized data from the 1990s based on six-core biopsies and outdated grading systems. OBJECTIVE: We prospectively gathered data from men undergoing prostate biopsy in multiple diverse North American and European institutions participating in the Prostate Biopsy Collaborative Group (PBCG) in order to build a state-of-the-art risk prediction tool...
May 16, 2018: European Urology
https://www.readbyqxmd.com/read/29772103/how-can-we-expand-active-surveillance-criteria-in-patients-with-low-and-intermediate-risk-prostate-cancer-without-increasing-the-risk-of-misclassification-development-of-a-novel-risk-calculator
#3
Giorgio Gandaglia, Roderick C N van den Bergh, Derya Tilki, Nicola Fossati, Piet Ost, Christian I Surcel, Prasanna Sooriakumaran, Igor Tsaur, Massimo Valerio, Alexander Kretschmer, Emanuele Zaffuto, Laurent Salomon, Francesco Montorsi, Markus Graefen, Henk van der Poel, Alexandre de la Taille, Alberto Briganti, Guillaume Ploussard
OBJECTIVE: To develop a novel tool to increase the number of prostate cancer (PCa) patients eligible for active surveillance (AS) without increasing the risk of unfavourable pathologic features (i.e., misclassification) at radical prostatectomy (RP). MATERIALS AND METHODS: Overall, 16,049 patients with low- or intermediate risk PCa treated with RP were identified. Misclassification was defined as non-organ confined or grade group ≥3 disease at RP. The coefficients of a logistic regression model predicting misclassification were used to develop a risk score...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29740587/the-effect-of-anatomical-location-of-lymph-node-metastases-on-cancer-specific-survival-in-patients-with-clear-cell-renal-cell-carcinoma
#4
Alessandro Nini, Alessandro Larcher, Francesco Cianflone, Francesco Trevisani, Carlo Terrone, Alessandro Volpe, Federica Regis, Alberto Briganti, Andrea Salonia, Francesco Montorsi, Roberto Bertini, Umberto Capitanio
Background: Positive nodal status (pN1) is an independent predictor of survival in renal cell carcinoma (RCC) patients. However, no study to date has tested whether the location of lymph node (LN) metastases does affect oncologic outcomes in a population submitted to radical nephrectomy (RN) and extended lymph node dissection (eLND). Objective: To describe nodal disease dissemination in clear cell RCC (ccRCC) patients and to assess the effect of the anatomical sites and the number of nodal areas affected on cancer specific mortality (CSM)...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29739253/the-effect-of-institution-teaching-status-on-perioperative-outcomes-after-robotic-partial-or-radical-nephrectomy
#5
Michele Marchioni, Sebastiano Nazzani, Felix Preisser, Marco Bandini, Zhe Tian, Anil Kapoor, Luca Cindolo, Giulia Primiceri, Luca Carmignani, Alberto Briganti, Francesco Montorsi, Shahrokh F Shariat, Luigi Schips, Pierre I Karakiewicz
OBJECTIVES: To test rates over time of robotic partial and radical nephrectomy (RPN and RRN) at teaching vs. non-teaching institutions and to examine associated complication rates and length of stay. MATERIAL AND METHODS: Within the Nationwide Inpatient Sample (2008-2013), after stratification according to institutional teaching status, we examined the rates of robotic, open and laparoscopic PN and RN. Subsequently, we tested complication rates and length of stay associated with RPN or RRN according to institutional teaching status...
May 9, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29720348/impact-of-adjuvant-radiotherapy-in-node-positive-prostate-cancer-patients-the-importance-of-patient-selection
#6
Firas Abdollah, Deepansh Dalela, Akshay Sood, Jacob Keeley, Shaheen Alanee, Alberto Briganti, Francesco Montorsi, James O Peabody, Mani Menon
Using institutional data, we have previously developed an algorithm to identify the optimal candidates for adjuvant radiotherapy (aRT) among men with pN1 prostate cancer (PCa) at radical prostatectomy (RP). This study aimed to test the external validity of our previous findings using a nationwide database while focusing on overall mortality as an endpoint. To this end, we identified 5498 pN1 PCa patients who were treated with RP, pelvic lymph node dissection, and androgen deprivation therapy with or without aRT, within the National Cancer Database, between 2004 and 2015...
April 29, 2018: European Urology
https://www.readbyqxmd.com/read/29717358/survival-after-radical-prostatectomy-or-radiotherapy-for-locally-advanced-ct3-prostate-cancer
#7
Marco Bandini, Michele Marchioni, Felix Preisser, Emanuele Zaffuto, Zhe Tian, Derya Tilki, Francesco Montorsi, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Pierre I Karakiewicz
PURPOSE: No prospective data examined the effect of radical prostatectomy (RP) vs. external beam radiotherapy (EBRT) in locally advanced prostate cancer (PCa). We aimed to compare survival outcomes of RP and EBRT in patients harboring cT3N0-1 PCa. METHODS: Within the SEER database (2004-2014), we identified 5500 cT3N0-1 PCa patients. Cumulative incidence plots and competing-risks regression models (CRRs) tested cancer-specific mortality (CSM) and other cause of mortality (OCM) according to treatment type...
May 2, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29704059/contemporary-rates-of-adherence-to-international-guidelines-for-pelvic-lymph-node-dissection-in-radical-cystectomy-a-population-based-study
#8
Emanuele Zaffuto, Marco Bandini, Stéphanie Gazdovich, Anne-Sophie Valiquette, Sami-Ramzi Leyh-Bannurah, Zhe Tian, Paolo Dell'Oglio, Markus Graefen, Marco Moschini, Andrea Necchi, Shahrokh F Shariat, Alberto Briganti, Francesco Montorsi, Pierre I Karakiewicz
OBJECTIVE: To examine the rates of adherence to guidelines for pelvic lymph node dissection (PLND) in patients treated with radical cystectomy (RC) and to identify predictors of omitting PLND. MATERIALS AND METHODS: We relied on 66,208 patients treated with RC between 2004 and 2013 within the National Inpatients Sample (NIS) database. We examined the rates of PLND according to year of surgery, patient and hospital characteristics. Univariate and multivariate logistic regression analyses assessed the probability of PLND use, after adjusting for year of surgery, age, gender, race, comorbidities, hospital location, teaching status and hospital surgical volume...
April 27, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29687951/lymph-node-dissection-during-radical-prostatectomy-for-prostate-cancer-extending-the-template-in-the-right-patients-without-increasing-complications
#9
EDITORIAL
Eugenio Ventimiglia, Alberto Briganti, Francesco Montorsi
No abstract text is available yet for this article.
May 2018: BJU International
https://www.readbyqxmd.com/read/29685788/preoperative-prediction-of-node-metastases-in-bladder-cancer-patients-using-genomic-and-clinicopathologic-data
#10
Marco Moschini, Francesco Montorsi
No abstract text is available yet for this article.
April 7, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29676063/development-and-internal-validation-of-a-side-specific-multiparametric-mri-based-nomogram-for-the-prediction-of-extracapsular-extension-of-prostate-cancer
#11
Alberto Martini, Akriti Gupta, Sara C Lewis, Shivaram Cumarasamy, Kenneth G Haines, Alberto Briganti, Francesco Montorsi, Ash K Tewari
OBJECTIVES: To develop a nomogram for predicting side-specific extracapsular extension (ECE) for planning nerve sparing radical prostatectomy (NSRP). MATERIALS AND METHODS: We retrospectively analyzed data from 561 patients who underwent robot-assisted radical prostatectomy between February 2014 and October 2015. To develop a side-specific predictive model, we considered the prostatic lobes separately. Four variables were included: PSA, highest ipsilateral biopsy Gleason grade, highest ipsilateral percentage core involvement and ECE on multiparametric MRI (mpMRI)...
April 19, 2018: BJU International
https://www.readbyqxmd.com/read/29644184/anastomotic-leaks-and-catheter-time-after-salvage-robot-assisted-radical-prostatectomy
#12
EDITORIAL
Marco Bandini, Giorgio Gandaglia, Nicola Fossati, Francesco Montorsi, Alberto Briganti
No abstract text is available yet for this article.
March 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29625757/will-image-guided-metastasis-directed-therapy-change-the-treatment-paradigm-of-oligorecurrent-prostate-cancer
#13
EDITORIAL
Gianluca Giannarini, Nicola Fossati, Giorgio Gandaglia, Vito Cucchiara, Vincenzo Ficarra, Vincenzo Mirone, Francesco Montorsi, Alberto Briganti
No abstract text is available yet for this article.
April 3, 2018: European Urology
https://www.readbyqxmd.com/read/29611674/augmented-reality-during-robot-assisted-radical-prostatectomy-expert-robotic-surgeons-on-the-spot-insights-after-live-surgery
#14
Francesco Porpiglia, Riccardo Bertolo, Daniele Amparore, Enrico Checcucci, Walter Artibani, Prokar Dasgupta, Francesco Montorsi, Ashutosh Tewari, Cristian Fiori
3D reconstruction of the standard two-dimension cross-sectional imaging has known increasing diffusion. It may represent one of the key points for a tailored treatment planning. Along these lines, we used a novel software for augmented-reality robot-assisted radical prostatectomy (AR-RARP) at our Institution. 3D virtual models of the prostate and the prostate cancer were reconstructed from high resolution (1-mm slices) multi-parametric Magnetic Resonance Imaging (mp-MRI) by M3dics (Turin, Italy). The innovation in the study is represented by the software-based integration of the virtual model inside the Da Vinci (Intuitive, Sunnyvale, CA, USA) robotic console during robotic prostatectomy...
April 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29611369/the-role-of-neutrophil-to-lymphocyte-ratio-in-men-with-erectile-dysfunction-preliminary-findings-of-a-real-life-cross-sectional-study
#15
E Ventimiglia, W Cazzaniga, F Pederzoli, N Frego, F Chierigo, P Capogrosso, L Boeri, F Dehò, C Abbate, D Moretti, L Piemonti, F Montorsi, A Salonia
The aim of this study was to investigate the role of systemic inflammation by means of the neutrophil-to-lymphocyte ratio (NLR) in men with erectile dysfunction (ED). Complete demographic, clinical, and laboratory data from 279 consecutive men with newly diagnosed ED were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). A complete blood count was requested for every man, and the NLR was calculated for every individual. Patients were invited to complete the IIEF questionnaire...
April 2, 2018: Andrology
https://www.readbyqxmd.com/read/29607150/robotic-surgery-video-assisted-thoracic-surgery-and-open-surgery-for-early-stage-lung-cancer-comparison-of-costs-and-outcomes-at-a-single-institute
#16
Pierluigi Novellis, Edoardo Bottoni, Emanuele Voulaz, Umberto Cariboni, Alberto Testori, Luca Bertolaccini, Laura Giordano, Elisa Dieci, Lorenzo Granato, Elena Vanni, Marco Montorsi, Marco Alloisio, Giulia Veronesi
Background: Robotic surgery is increasingly used to resect lung cancer. However costs are high. We compared costs and outcomes for robotic surgery, video-assisted thoracic surgery (VATS), and open surgery, to treat non-small cell lung cancer (NSCLC). Methods: We retrospectively assessed 103 consecutive patients given lobectomy or segmentectomy for clinical stage I or II NSCLC. Three surgeons could choose VATS or open, the fourth could choose between all three techniques...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29603918/the-effect-of-age-on-cancer-specific-mortality-in-patients-with-small-renal-masses-a-population-based-analysis
#17
Marco Bandini, Michele Marchioni, Raisa S Pompe, Zhe Tian, Tristan Martel, Felix K Chun, Luca Cindolo, Anil Kapoor, Francesco Montorsi, Shahrokh F Shariat, Alberto Briganti, Pierre I Karakiewicz
INTRODUCTION: Contemporary data regarding the effect of age, especially in the elderly patients, on cancer-specific mortality (CSM) for pT1a renal cell cancer (RCC) are lacking. The objective of the current study is to evaluate CSM in a large population-based cohort of surgically treated pT1a RCC patients according to age groups. METHODS: Within the Surveillance Epidemiology and End Results database (2000-2013), we identified 37 121 pT1a RCC patients who underwent either partial or radical nephrectomy...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29603911/treatment-trends-and-medicare-reimbursements-for-localized-prostate-cancer-in-elderly-patients
#18
Paolo Dell'oglio, Anne Sophie Valiquette, Sami-Ramzi Leyh-Bannurah, Zhe Tian, Vincent Trudeau, Alessandro Larcher, Shahrokh F Shariat, Umberto Capitanio, Alberto Briganti, Markus Graefen, Francesco Montorsi, Pierre I Karakiewicz
INTRODUCTION: The absolute and proportional numbers of elderly patients diagnosed with localized prostate cancer (PCa) are on the rise. We examined treatment trends and reimbursement figures in localized PCa patients aged ≥80 years. METHODS: Between 2000 and 2008, we identified 30 217 localized PCa patients aged ≥80 years in Surveillance, Epidemiology and End Results (SEER)-Medicare-linked database. Alternative treatment modalities consisted of conservative management (CM), radiation therapy (RT), radical prostatectomy (RP), and primary androgen-deprivation therapy (PADT)...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29602638/pattern-of-node-metastases-in-patients-treated-with-radical-cystectomy-and-extended-or-superextended-pelvic-lymph-node-dissection-due-to-bladder-cancer
#19
Marco Moschini, Emilio Arbelaez, Julian Cornelius, Agostino Mattei, Shahrokh F Shariat, Paolo Dell Oglio, Emanuele Zaffuto, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina
BACKGROUND: Pelvic lymph node dissection (PLND) has a diagnostic and therapeutic role during radical cystectomy in bladder cancer patients. However, at the time, no prospective data supports the value of extended PLND in improving survival expectances. We sought to describe incidence and location of node metastases in patients treated with extended and superextended PLND. METHODS: We evaluated 653 contemporary patients with clinically nonmetastatic high risk nonmuscle invasive or muscle-invasive bladder cancer treated with radical cystectomy and extended or superextended PLND without neoadjuvant chemotherapy at a single tertiary referral center between 1990 and 2013...
March 27, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29595040/male-infertility-as-a-proxy-of-the-overall-male-health-status
#20
Paolo Capogrosso, Eugenio Ventimiglia, Luca Boeri, Walter Cazzaniga, Francesco Chierigo, Francesco Montorsi, Andrea Salonia
INTRODUCTION: Male infertility (MI) has been widely associated with different comorbid conditions. The aim of this review is to summarize the available evidences investigating the link between MI cancer, chronic non-malignant conditions and overall health. EVIDENCE ACQUISITION: A literature search has been conducted using the MEDLINE/PubMed and Scopus databases for English-language original and review articles and selecting publications from January 2007 to June 2017, although highly regarded older publications were also considered...
March 28, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
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