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https://www.readbyqxmd.com/read/28418063/ab-initio-modelling-of-oxygen-vacancy-arrangement-in-highly-defective-hfo2-resistive-layers
#1
Luca Sementa, Luca Larcher, Giovanni Barcaro, Monia Montorsi
We report ab initio results for sub-stoichiometric HfOx with different oxygen vacancy densities, useful in exploring microscopic mechanisms that govern the operation of RRAM devices. We demonstrate that oxygen vacancy filaments are energetically more stable than randomly distributed defects. Furthermore, the stability of the filaments increases with the number of confined oxygen vacancies. Energetic and structural analyses show that bonds between neighboring coordinative unsaturated Hf atoms promote filament stability, and electron trapping, due to electron injection, increases the cohesive energy until the injection is moderate...
April 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28413126/consensus-statement-of-the-european-urology-association-and-the-european-urogynaecological-association-on-the-use-of-implanted-materials-for-treating-pelvic-organ-prolapse-and-stress-urinary-incontinence
#2
REVIEW
Christopher R Chapple, Francisco Cruz, Xavier Deffieux, Alfredo L Milani, Salvador Arlandis, Walter Artibani, Ricarda M Bauer, Fiona Burkhard, Linda Cardozo, David Castro-Diaz, Jean Nicolas Cornu, Jan Deprest, Alfons Gunnemann, Maria Gyhagen, John Heesakkers, Heinz Koelbl, Sheila MacNeil, Gert Naumann, Jan-Paul W R Roovers, Stefano Salvatore, Karl-Dietrich Sievert, Tufan Tarcan, Frank Van der Aa, Francesco Montorsi, Manfred Wirth, Mohamed Abdel-Fattah
CONTEXT: Surgical nonautologous meshes have been used for several decades to repair abdominal wall herniae. Implantable materials have been adopted for the treatment of female and male stress urinary incontinence (SUI) and female pelvic organ prolapse (POP). OBJECTIVE: A consensus review of existing data based on published meta-analyses and reviews. EVIDENCE ACQUISITION: This document summarises the deliberations of a consensus group meeting convened by the European Association of Urology (EAU) and the European Urogynecological Association, to explore the current evidence relating to the use of polypropylene (PP) materials used for the treatment of SUI and POP, with reference to the 2016 EAU guidelines (European Association of Urology 2016), the European Commission's SCENIHR report on the use of surgical meshes (SCENIHR 2015), other available high-quality evidence, guidelines, and national recommendations...
April 13, 2017: European Urology
https://www.readbyqxmd.com/read/28412062/development-and-internal-validation-of-a-novel-model-to-identify-the-candidates-for-extended-pelvic-lymph-node-dissection-in-prostate-cancer
#3
Giorgio Gandaglia, Nicola Fossati, Emanuele Zaffuto, Marco Bandini, Paolo Dell'Oglio, Carlo Andrea Bravi, Giuseppe Fallara, Francesco Pellegrino, Luigi Nocera, Pierre I Karakiewicz, Zhe Tian, Massimo Freschi, Rodolfo Montironi, Francesco Montorsi, Alberto Briganti
BACKGROUND: Preoperative assessment of the risk of lymph node invasion (LNI) is mandatory to identify prostate cancer (PCa) patients who should receive an extended pelvic lymph node dissection (ePLND). OBJECTIVE: To update a nomogram predicting LNI in contemporary PCa patients with detailed biopsy reports. DESIGN, SETTING, AND PARTICIPANTS: Overall, 681 patients with detailed biopsy information, evaluated by a high-volume uropathologist, treated with radical prostatectomy and ePLND between 2011 and 2016 were identified...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28409903/primary-secondary-and-compensated-hypogonadism-a-novel-risk-stratification-for-infertile-men
#4
E Ventimiglia, S Ippolito, P Capogrosso, F Pederzoli, W Cazzaniga, L Boeri, I Cavarretta, M Alfano, P Viganò, F Montorsi, A Salonia
Recently, the cohort of men from the European Male Ageing Study has been stratified into different categories distinguishing primary, secondary and compensated hypogonadism. A similar classification has not yet been applied to the infertile population. We performed a cross-sectional study enrolling 786 consecutive Caucasian-European infertile men segregated into eugonadal [normal serum total testosterone (≥3.03 ng/mL) and normal luteinizing hormone (≤9.4 mU/mL)], secondary (low total testosterone, low/normal luteinizing hormone), primary (low total testosterone, elevated luteinizing hormone) and compensated hypogonadism (normal total testosterone; elevated luteinizing hormone)...
May 2017: Andrology
https://www.readbyqxmd.com/read/28393494/is-there-a-role-for-pure-clinical-prediction-models-in-prostate-cancer-in-the-contemporary-era
#5
EDITORIAL
Giorgio Gandaglia, Nicola Fossati, Paolo Dell'Oglio, Francesco Montorsi, Alberto Briganti
No abstract text is available yet for this article.
May 2017: BJU International
https://www.readbyqxmd.com/read/28390817/numerical-analysis-of-an-entire-ceramic-kiln-under-actual-operating-conditions-for-the-energy-efficiency-improvement
#6
Massimo Milani, Luca Montorsi, Matteo Stefani, Roberto Saponelli, Maurizio Lizzano
The paper focuses on the analysis of an industrial ceramic kiln in order to improve the energy efficiency and thus the fuel consumption and the corresponding carbon dioxide emissions. A lumped and distributed parameter model of the entire system is constructed to simulate the performance of the kiln under actual operating conditions. The model is able to predict accurately the temperature distribution along the different modules of the kiln and the operation of the many natural gas burners employed to provide the required thermal power...
April 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28385454/local-therapy-improves-survival-in-metastatic-prostate-cancer
#7
Sami-Ramzi Leyh-Bannurah, Stéphanie Gazdovich, Lars Budäus, Emanuele Zaffuto, Alberto Briganti, Firas Abdollah, Francesco Montorsi, Jonas Schiffmann, Mani Menon, Shahrokh F Shariat, Margit Fisch, Felix Chun, Thomas Steuber, Hartwig Huland, Markus Graefen, Pierre I Karakiewicz
BACKGROUND: Treatment of the primary, termed local therapy (LT), may improve survival in metastatic prostate cancer (mPCa) versus no local therapy (NLT). OBJECTIVE: To assess cancer-specific mortality (CSM) after LT versus NLT in mPCa. DESIGN, SETTING, AND PARTICIPANTS: Within the Surveillance, Epidemiology and End Results database (2004-2013), 13 692 mPCa patients were treated with LT (radical prostatectomy [RP] or radiation therapy [RT]) or NLT...
April 3, 2017: European Urology
https://www.readbyqxmd.com/read/28359746/are-all-grade-group-4-prostate-cancers-created-equal-implications-for-the-applicability-of-the-novel-grade-grouping
#8
Giorgio Gandaglia, R Jeffrey Karnes, Arjun Sivaraman, Marco Moschini, Nicola Fossati, Emanuele Zaffuto, Paolo DellʼOglio, Xavier Cathelineau, Francesco Montorsi, Rafael Sanchez-Salas, Alberto Briganti
BACKGROUND: According to the novel prostate cancer (PCa) grade grouping, men with Gleason score 8 should be included in the grade group 4 regardless of primary and secondary scores. We aimed at evaluating the effect of Gleason patterns on the risk of recurrence in men with grade group 4 PCa. PATIENTS AND METHODS: Overall, 1,089 patients treated with radical prostatectomy with grade group 4 PCa at final pathology were identified. Biochemical recurrence (BCR) was defined as 2 consecutive prostate-specific antigen values≥0...
March 27, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28330822/long-term-survival-of-patients-aged-80-years-or-older-treated-with-radical-prostatectomy-for-prostate-cancer
#9
P Dell'Oglio, E Zaffuto, K Boehm, V Trudeau, A Larcher, Z Tian, M Moschini, S F Shariat, M Graefen, F Saad, U Capitanio, A Briganti, F Montorsi, P I Karakiewicz
BACKGROUND: Radical prostatectomy (RP) is the gold standard for clinically localized prostate cancer (PCa) patients with life expectancy (LE) of at least 10 years. We examined long-term survival of men aged 80 years or older treated with RP and we attempted to identify criteria based on age and comorbidities that could predict survival of at least 10 years after RP, to identify those that might be considered for RP. PATIENTS AND METHODS: In Surveillance Epidemiology and End Results (SEER)-Medicare-linked database, we identified 234 octo- and nonagenarians with clinical T1, T2 or T3 PCa treated with RP between 1991 and 2009...
March 10, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28295051/six-out-of-ten-women-with-recurrent-urinary-tract-infections-complain-of-distressful-sexual-dysfunction-a-case-control-study
#10
Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Roberta Scano, Alessandra Graziottin, Federico Dehò, Emanuele Montanari, Francesco Montorsi, Andrea Salonia
Uncomplicated recurrent urinary tract infections (rUTIs) are common among reproductive-aged women. We aimed to assess the prevalence and predictors of sexual dysfunction (FSD) in a cohort of women with rUTIs and compare their psychometric scores to those of matched controls. Data from 147 rUTIs women and 150 healthy controls were analysed. Participants completed the International Prostatic Symptoms Score (IPSS), the Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (SDS). Descriptive statistics and logistic regression models tested prevalence and predictors of distressful FSD...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275033/short-form-charlson-comorbidity-index-for-assessment-of-perioperative-mortality-after-radical-cystectomy
#11
Paolo Dell'Oglio, Zhe Tian, Sami-Ramzi Leyh-Bannurah, Vincent Trudeau, Alessandro Larcher, Marco Moschini, Ettore Di Trapani, Umberto Capitanio, Alberto Briganti, Francesco Montorsi, Fred Saad, Pierre I Karakiewicz
Background: The Deyo adaptation of the Charlson comorbidity index (DaCCI), which relies on 17 comorbid condition groupings, represents one of the most frequently used baseline comorbidity assessment tools in retrospective database studies. However, this index is not specific for patients with bladder cancer (BCa) treated with radical cystectomy (RC). The goal of this study was to develop a short-form of the original DaCCI (DaCCI-SF) that may specifically predict 90-day mortality after RC, with equal or better accuracy...
March 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28267892/the-great-opportunity-of-the-andrological-patient-cardiovascular-and-metabolic-risk-assessment-and-prevention
#12
C Foresta, A Ferlin, A Lenzi, P Montorsi
Andrologists, cardiologists and diabetologists (and general practitioners) have the great opportunity to collaborate and find shared clinical workup for the benefit of a large number of men. Several evidence established a link between erectile dysfunction (ED), cardiovascular disease (CVD), diabetes, and metabolic syndrome. Not only these conditions share many risk factors and pathophysiological mechanisms but also an emerging paradigm indicates that ED is, in fact, an independent marker of cardiovascular disease risk, CV events and CV mortality...
March 7, 2017: Andrology
https://www.readbyqxmd.com/read/28247066/trends-of-lymphadenectomy-in-upper-tract-urothelial-carcinoma-utuc-patients-treated-with-radical-nephroureterectomy
#13
Marco Moschini, Beat Foerster, Mohammad Abufaraj, Francesco Soria, Thomas Seisen, Morgan Roupret, Pierre Colin, Alexandre De la Taille, Benoit Peyronnet, Karim Bensalah, Roman Herout, Manfred Peter Wirth, Vladimir Novotny, Piotr Chlosta, Marco Bandini, Francesco Montorsi, Giuseppe Simone, Michele Gallucci, Giuseppe Romeo, Kazumasa Matsumoto, Pierre Karakiewicz, Alberto Briganti, Shahrokh F Shariat
INTRODUCTION: To evaluate temporal trends in the delivery and extent of lymphadenectomy (LND) in radical nephroureterectomy (RNU) performed in upper tract urothelial carcinoma (UTUC) patients. METHODS: We evaluated a multi institutional collaborative database composed by 1512 consecutive patients diagnosed with UTUC treated with RNU between 1990 and 2016. Year of surgery were grouped in five periods: 1990-1996, 1997-2002, 2003-2007, 2008-2012 and 2013-2016. Data about LND were available for all patients and numbers of nodes removed and positive were reported by dedicate uropathologists...
February 28, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28220605/outcome-predictors-of-radical-cystectomy-in-patients-with-ct4-prostate-cancer-a-multi-institutional-study-of-62-patients
#14
Martin Spahn, Alessandro Morlacco, Silvan Boxler, Steven Joniau, Alberto Briganti, Francesco Montorsi, Paolo Gontero, Pia Bader, Detlef Frohneberg, Hein van Poppel, R Jeffrey Karnes
OBJECTIVES: To identify which patients with macroscopic bladder infiltrating T4 prostate cancer (PCa) might have favorable outcomes when treated with radical cystectomy (RC) MATERIALS AND METHODS: We evaluated 62 patients with cT4cN0-1cM0 PCa treated with RC and pelvic lymph node dissection between 1972-2011. In addition to descriptive statistics, the Kaplan-Meier method and log-rank tests were used to depict survival rates. Uni- and multivariate Cox regression analysis tested the association between predictors and progression-free, PCa-specific-, and overall survival...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28191815/bladder-cancer-cell-growth-and-motility-implicate-cannabinoid-2-receptor-mediated-modifications-of-sphingolipids-metabolism
#15
Arianna Bettiga, Massimo Aureli, Giorgia Colciago, Valentina Murdica, Marco Moschini, Roberta Lucianò, Daniel Canals, Yusuf Hannun, Petter Hedlund, Giovanni Lavorgna, Renzo Colombo, Rosaria Bassi, Maura Samarani, Francesco Montorsi, Andrea Salonia, Fabio Benigni
The inhibitory effects demonstrated by activation of cannabinoid receptors (CB) on cancer proliferation and migration may also play critical roles in controlling bladder cancer (BC). CB expression on human normal and BC specimens was tested by immunohistochemistry. Human BC cells RT4 and RT112 were challenged with CB agonists and assessed for proliferation, apoptosis, and motility. Cellular sphingolipids (SL) constitution and metabolism were evaluated after metabolic labelling. CB1-2 were detected in BC specimens, but only CB2 was more expressed in the tumour...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28162943/impact-of-intra-and-postoperative-blood-transfusion-on-the-incidence-timing-and-pattern-of-disease-recurrence-after-radical%C3%A2-cystectomy
#16
Marco Moschini, Francesco Soria, Mohammad Abufaraj, Beat Foerster, David D'Andrea, Rocco Damiano, Tobias Klatte, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina, Shahrokh F Shariat
BACKGROUND: The administration of blood transfusion (BT) has been associated with a decrease in survival expectancies in patients treated with radical cystectomy (RC), as a consequence of the immunosuppressive effect mediated by BT. We sought therefore to evaluate if the usage of BT may influence the risk and pattern location of distant recurrences after RC, which may be influenced by this effect. METHODS: Data from 2 independent cohorts of consecutive patients with bladder cancer treated with RC were analyzed...
January 11, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28150483/from-gold-standard-resection-to-reproducible-future-standard-endoscopic-enucleation-of-the-prostate-eep-what-we-know-about-anatomical-enucleation
#17
Richard Naspro, Fernando Gomez Sancha, Michele Manica, Agostino Meneghini, Sascha Ahyai, Tevita Aho, Cristian Fiori, Ivano Vavassori, Luigi F DA Pozzo, Vito Pansadoro, Francesco Montorsi, Thomas R Herrmann
INTRODUCTION: Open prostatectomy (OP) and transurethral resection of the prostate (TURP) have traditionally been the most common surgical approaches for the treatment of benign prostatic hyperplasia causing bladder outlet obstruction and have certainly passed the test of time. In time, many endoscopic surgical procedures have been described as an alternative mini-invasive treatment. Holmium laser enucleation (HoLEP) guaranteed functional outcomes similar to OP and TURP with lower peri-operative complication rates for any prostate size...
February 1, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28142141/impact-of-prostate-involvement-on-outcomes-in-patients-treated-with-radical-cystoprostatectomy-for-bladder-cancer
#18
Marco Moschini, Shahrokh F Shariat, Massimo Freschi, Francesco Soria, Mohammad Abufaraj, Giorgio Gandaglia, Paolo Dell'Oglio, Agostino Mattei, Rocco Damiano, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Renzo Colombo
OBJECTIVE: The study aimed to evaluate the impact of the different types of prostate involvement at the time of radical cystoprostatectomy (RCP). METHODS: Data from 893 male patients treated with RCP at a referral center for bladder cancer (BCa) were assessed. Prostatic urothelial carcinoma (PUC) was stratified as stromal vs. urethral/duct involvements. Multivariable Cox regression analyses were built to test the impact of the presence of incidental prostate cancer (PCa) and PUC on survival outcomes...
2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28129714/time-of-onset-of-vardenafil-orodispersible-tablet-in-a-real-life-setting-looking-beyond-randomized-clinical-trials
#19
Paolo Capogrosso, Eugenio Ventimiglia, Luca Boeri, Alessandro Serino, Andrea Russo, Giovanni La Croce, Umberto Capitanio, Federico Dehò, Francesco Montorsi, Andrea Salonia
BACKGROUND: A rapid onset of action for phosphodiesterase type 5 inhibitors (PDE5is) emerged to be of clinical importance in men treated for erectile dysfunction (ED). Data from randomized clinical trials (RCTs) showed a rapid onset of action for vardenafil 10 mg orodispersible tablet (ODT). However, the effectiveness of vardenafil ODT has never been tested in a real-life setting. We assessed the efficacy and time to onset of action of vardenafil ODT in men seeking medical help for ED in the everyday real-life clinical practice...
March 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28093788/north-american-population-based-validation-of-the-national-comprehensive-cancer-network-practice-guideline-recommendation-of-pelvic-lymphadenectomy-in-contemporary-prostate-cancer
#20
Sami-Ramzi Leyh-Bannurah, Lars Budäus, Raisa Pompe, Emanuele Zaffuto, Alberto Briganti, Firas Abdollah, Francesco Montorsi, Jonas Schiffmann, Mani Menon, Shahrokh F Shariat, Margit Fisch, Felix Chun, Hartwig Huland, Markus Graefen, Pierre I Karakiewicz
BACKGROUND: National Comprehensive Cancer Network (NCCN) guidelines recommend a pelvic lymph node dissection (PLND) in prostate cancer (PCa) patients treated with radical prostatectomy (RP) if a nomogram predicted risk of lymph node invasion (LNI) is ≥2%. We examined this and other thresholds, including nomogram validation. METHODS: We examined records of 26,713 patients treated with RP and PLND between 2010 and 2013, within the Surveillance, Epidemiology, and End Results database...
January 17, 2017: Prostate
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