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Luca Villa, Roberta Buono, Mara Ferrandi, Isabella Molinari, Fabio Benigni, Arianna Bettiga, Giorgia Colciago, Masami Ikehata, Elisabetta Messaggio, Maria Pia Rastaldi, Francesco Montorsi, Andrea Salonia, Paolo Manunta
Warm renal ischemia performed during partial nephrectomy has been found to be associated with kidney disease. Since endogenous ouabain (EO) is a neuro-endocrine hormone involved in renal damage, we evaluated the role of EO in renal ischemia-reperfusion injury (IRI). We measured plasma and renal EO variations and markers of glomerular and tubular damage (nephrin, KIM-1, Kidney-Injury-Molecule-1, α1 Na-K ATPase) and the protective effect of the ouabain inhibitor, rostafuroxin. We studied five groups of rats: (1) normal; (2) infused for eight weeks with ouabain (30 µg/kg/day, OHR) or (3) saline; (4) ouabain; or (5) saline-infused rats orally treated with 100 µg/kg/day rostafuroxin for four weeks...
October 14, 2016: International Journal of Molecular Sciences
Marco Moschini, Vidit Sharma, Giorgio Gandaglia, Paolo Dell'Oglio, Nicola Fossati, Emanuele Zaffuto, Francesco Montorsi, Alberto Briganti, R Jeffrey Karnes
INTRODUCTION: The literature is conflicting on the long-term utility of adjuvant therapy after radical prostatectomy (RP) for prostate cancer (PCa) demonstrating seminal vesicle invasion (pT3b; SVI). METHODS: Patients with SVI during RP and pelvic lymph node dissection at two major referral centers from 1986-2014 were included. Kaplan-Meier analyses and multivariable Cox regressions were performed to determine if adjuvant radiotherapy (aRT) and adjuvant hormonal therapy (aHT) were predictors of biochemical recurrence, cancer specific mortality (CSM) and overall mortality (OM)...
October 18, 2016: BJU International
Paolo Dell'Oglio, Robert Jeffrey Karnes, Giorgio Gandaglia, Nicola Fossati, Armando Stabile, Marco Moschini, Vito Cucchiara, Emanuele Zaffuto, Pierre I Karakiewicz, Nazareno Suardi, Francesco Montorsi, Alberto Briganti
BACKGROUND: A new prostate cancer (PCa) grading system (namely, Gleason score-GS- ≤6 vs. 3 + 4 vs. 4 + 3 vs. 8 vs. ≥9) was recently proposed and assessed on biochemical recurrence (BCR) showing improved predictive abilities compared to the commonly used three-tier system (GS ≤6 vs. 7 vs. ≥8). We assessed the predictive ability of the five-tier grade group (GG) system on harder clinical endpoint, namely clinical recurrence (CR). METHODS: Between 2005 and 2014, 9,728 clinically localized PCa patients were treated with radical prostatectomy (RP) at two tertiary referral centers...
October 18, 2016: Prostate
Jonas Schiffmann, Maxine Sun, Giorgio Gandaglia, Zhe Tian, Ioana Popa, Alessandro Larcher, Alberto Briganti, Michael McCormack, Shahrokh F Shariat, Francesco Montorsi, Markus Graefen, Fred Saad, Pierre I Karakiewicz
BACKGROUND: The role of adjuvant chemotherapy (AC) within urothelial carcinoma of the urinary bladder (UCUB) patients after radical cystectomy (RC) is under debate. We assessed contemporary AC utilization rates. We also examined the rates of AC according to patient disease and sociodemographic characteristics. METHODS: We relied on the SEER-Medicare database for non-organ-confined, muscle-invasive T2 N+ -T4a UCUB patients who underwent RC between 1991 and 2009 without neoadjuvant chemotherapy delivery...
October 12, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
M Moschini, S Luzzago, E Zaffuto, P Dell'Oglio, G Gandaglia, A Mattei, R Damiano, F Soria, T Klatte, S F Shariat, A Salonia, F Montorsi, A Briganti, A Gallina, R Colombo
INTRODUCTION: Patients with clinical T4 (cT4) bladder cancer (BCa) infrequently undergo radical cystectomy (RC). We investigated the reliability of preoperative clinical staging, perioperative and survival outcomes in patients treated with RC due to cT4a-b BCa disease at a single tertiary care institution. METHODS: The study relied on 917 BCa patients treated with RC and pelvic lymph node dissection (PLND) at a single institution between January 1995 and December 2012...
September 28, 2016: European Journal of Surgical Oncology
Fara Uccelli, F Gavazzi, G Capretti, M Virdis, M Montorsi, A Zerbi
Enucleation (EN) and middle pancreatectomy (MP) have been proposed as a treatment for G1 and G2 pancreatic neuroendocrine tumors (PNET). The aim of this study is to analyze the outcomes of parenchyma-sparing surgery (PSS) for PNET in an Italian high-volume center. All patients with a histological diagnosis of PNET who underwent surgical resection in our center between January 2010 and January 2016 were included in the study. Demographic, perioperative, and discharge data were collected in a prospective database...
October 5, 2016: Updates in Surgery
Marc G Besselink, L Bengt van Rijssen, Claudio Bassi, Christos Dervenis, Marco Montorsi, Mustapha Adham, Horacio J Asbun, Maximillian Bockhorn, Oliver Strobel, Markus W Büchler, Olivier R Busch, Richard M Charnley, Kevin C Conlon, Laureano Fernández-Cruz, Abe Fingerhut, Helmut Friess, Jakob R Izbicki, Keith D Lillemoe, John P Neoptolemos, Michael G Sarr, Shailesh V Shrikhande, Robert Sitarz, Charles M Vollmer, Charles J Yeo, Werner Hartwig, Christopher L Wolfgang, Dirk J Gouma
BACKGROUND: Recent literature suggests that chyle leak may complicate up to 10% of pancreatic resections. Treatment depends on its severity, which may include chylous ascites. No international consensus definition or grading system of chyle leak currently is available. METHODS: The International Study Group on Pancreatic Surgery, an international panel of pancreatic surgeons working in well-known, high-volume centers, reviewed the literature and worked together to establish a consensus on the definition and classification of chyle leak after pancreatic operation...
September 28, 2016: Surgery
A Larcher, M Sun, P Dell'Oglio, V Trudeau, K Boehm, J Schiffmann, Z Tian, N Fossati, U Capitanio, A Briganti, F Montorsi, P Karakiewicz
BACKGROUND: Local tumour ablation (LTA) may yield better perioperative outcomes than partial nephrectomy (PN), however the impact of each treatment on perioperative mortality and health care expenditures is unknown. The aim of the study was to compare mortality, morbidity and health care expenditures between LTA and PN. PATIENTS AND METHODS: A population-based assessment of 2471 patients with cT1a kidney cancer treated with either LTA or PN, between 2000 and 2009, in the SEER-Medicare database was performed...
September 17, 2016: European Journal of Surgical Oncology
Alessandro Larcher, Paolo Dell'Oglio, Nicola Fossati, Alessandro Nini, Fabio Muttin, Nazareno Suardi, Francesco De Cobelli, Andrea Salonia, Alberto Briganti, Xu Zhang, Francesco Montorsi, Roberto Bertini, Umberto Capitanio
OBJECTIVES: To provide objective criteria for preoperative staging chest computed tomography [CCT] in patients diagnosed with renal cell carcinoma [RCC], since, in absence of established indications, the decision for preoperative CCT remains subjective. PATIENTS AND METHODS: 1,946 patients elected for surgical treatment of RCC and collected in a prospective institutional database were assessed. The outcome of the study was presence of pulmonary metastases at staging CCT...
September 29, 2016: BJU International
Sami-Ramzi Leyh-Bannurah, Stéphanie Gazdovich, Lars Budäus, Emanuele Zaffuto, Paolo Dell'Oglio, Alberto Briganti, Firas Abdollah, Francesco Montorsi, Jonas Schiffmann, Mani Menon, Shahrokh F Shariat, Margit Fisch, Felix Chun, Markus Graefen, Pierre I Karakiewicz
OBJECTIVE: To externally validate the updated 2012 Partin Tables in contemporary North American patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa) at community institutions. MATERIALS AND METHODS: We examined records of 25,254 patients treated with RP and pelvic lymph node dissection (PLND) between 2010 and 2013, within the surveillance, epidemiology, and end results database. The ROC derived AUC assessed discriminant properties of the updated 2012 Partin Tables of organ confined disease (OC), extracapsular extension (ECE), seminal vesical invasion (SVI), and lymph node invasion (LNI)...
September 29, 2016: Prostate
Laura-Maria Krabbe, Okyaz Eminaga, Shahrokh F Shariat, Ryan C Hutchinson, Yair Lotan, Arthur I Sagalowsky, Jay D Raman, Christopher G Wood, Alon Z Weizer, Marco Roscigno, Francesco Montorsi, Christian Bolenz, Giacomo Novara, Eiji Kikuchi, Harun Fajkovic, Leonid M Rapoport, Peter V Glybochko, Richard Zigeuner, Mesut Remzi, Karim Bensalah, Wassim Kassouf, Vitaly Margulis
PURPOSE: To develop a prognostic nomogram after extirpative for patients with high-grade UTUC. MATERIALS AND METHODS: Clinical data were available for 2,926 patients diagnosed with high-grade UTUC who underwent extirpative surgery. Cox proportional hazard regression models identified independent prognosticators of relapse in the development cohort (n=838). A backward step-down selection process was applied to achieve the most informative nomogram with the least number of variables...
September 23, 2016: Journal of Urology
Emanuele Zaffuto, Giorgio Gandaglia, Nicola Fossati, Paolo Dell'Oglio, Marco Moschini, Vito Cucchiara, Nazareno Suardi, Vincenzo Mirone, Marco Bandini, Shahrokh F Shariat, Pierre I Karakiewicz, Francesco Montorsi, Alberto Briganti
PURPOSE: The role of the time between radical prostatectomy (RP) and radiation therapy (RT) on postoperative functional outcomes is still unclear in surgically-managed prostate cancer (PCa) patients. We hypothesized that a shorter time interval between RP and RT might be associated with worse functional recovery rates after RP. MATERIALS AND METHODS: We retrospectively evaluated 2,190 patients treated with RP. Patients were stratified according to RT schedule (adjuvant RT, salvage RT, no RT)...
September 23, 2016: Journal of Urology
Paolo Capogrosso, Rafael Sanchez-Salas, Andrea Salonia, Nathalie Cathala, Annick Mombet, Arjun Sivaraman, Eric Barret, Francesco Montorsi, Xavier Cathelineau
INTRODUCTION: In the era of minimally-invasive surgery, urinary incontinence (UI) after radical prostatectomy (RP) still represents a troublesome issue for a considerable rate of patients. Factors associated with the risk of post-RP UI, need to be carefully assessed throughout the overall clinical management process thus including the pre-operative, intra-operative and post-operative setting. AREAS COVERED: This review analyses current published evidences regarding clinical and surgical aspects associated with urinary continence (UC) recovery after RP...
October 2016: Expert Review of Anticancer Therapy
Riccardo Schiavina, Lorenzo Bianchi, Marco Borghesi, Alberto Briganti, Eugenio Brunocilla, Marco Carini, Carlo Terrone, Alex Mottrie, Donato Dente, Mauro Gacci, Paolo Gontero, Alberto Gurioli, Ciro Imbimbo, Gaetano La Manna, Giansilvio Marchioro, Giulio Milanese, Vincenzo Mirone, Francesco Montorsi, Giuseppe Morgia, Stefania Munegato, Giacomo Novara, Daniele Panarello, Angelo Porreca, Giorgio I Russo, Sergio Serni, Alchide Simonato, Daniele Urzì, Paolo Verze, Alessandro Volpe, Giuseppe Martorana
OBJECTIVES: To investigate cancer-specific mortality and other-cause mortality in prostate cancer patients with nodal metastases. METHODS: The study included 411 patients treated with radical prostatectomy and pelvic lymph node dissection for prostate cancer with lymph node metastases at 10 tertiary care centers between 1995 and 2014. Kaplan-Meier analyses were used to assess cancer-specific mortality-free survival rates at 8 years' follow up in the overall population, and after stratifying patients according to clinical and pathological parameters...
September 12, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
Nicola Fossati, Peter Wiklund, Charles-Henry Rochat, Francesco Montorsi, Prokar Dasgupta, Rafael Sanchez-Salas, Abdullah E Canda, Thierry Piechaud, Walter Artibani, Alexandre Mottrie
Despite the finally acquired level 1 evidence, the urologic debate on open versus robotic prostatectomy still persists. This trial from Brisbane will encourage future studies that will better inform this debate and define what robotic surgery offers.
September 8, 2016: European Urology
Eugenio Ventimiglia, Andrea Salonia, Alberto Briganti, Francesco Montorsi
No abstract text is available yet for this article.
September 5, 2016: European Urology
Francesco Montorsi, Giorgio Gandaglia, Nicola Fossati, Nazareno Suardi, Cristian Pultrone, Ruben De Groote, Zach Dovey, Paolo Umari, Andrea Gallina, Alberto Briganti, Alexandre Mottrie
BACKGROUND: Salvage lymph node dissection has been described as a feasible treatment for the management of prostate cancer patients with nodal recurrence after primary treatment. OBJECTIVE: To report perioperative, pathologic, and oncologic outcomes of robot-assisted salvage nodal dissection (RASND) in patients with nodal recurrence after radical prostatectomy (RP). DESIGN, SETTING, AND PARTICIPANTS: We retrospectively evaluated 16 patients affected by nodal recurrence following RP documented by positive positron emission tomography/computed tomography scan...
September 3, 2016: European Urology
Alexis Laurent, Safi Dokmak, Jean-Charles Nault, François-René Pruvot, Jean-Michel Fabre, Christian Letoublon, Philippe Bachellier, Lorenzo Capussotti, Olivier Farges, Jean-Yves Mabrut, Yves-Patrice Le Treut, Ahmet Ayav, Bertrand Suc, Olivier Soubrane, Gilles Mentha, Irinel Popescu, Marco Montorsi, Nicolas Demartines, Jacques Belghiti, Guido Torzilli, Daniel Cherqui, Jean Hardwigsen
BACKGROUND: Hepatocellular adenoma (HCA) is a benign hepatic lesion that may be complicated by bleeding and malignant transformation. The aim of the present study is to report on large series of liver resections for HCA and assess the incidence of hemorrhage and malignant transformation. METHODS: A retrospective cross-sectional study, from 27 European high-volume HPB units. RESULTS: 573 patients were analyzed. The female: male gender ratio was 8:2, mean age: 37 ± 10 years...
September 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Marco Moschini, Stefano Luzzago, Walter Cazzaniga, Vito Cucchiara, Marco Bandini, Rocco Damiano, Francesco Soria, Tobias Klatte, Shahrokh F Shariat, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina
INTRODUCTION: We evaluated the effect of the year of surgery on the clinical, pathologic, and oncologic outcomes of patients with bladder cancer (BCa) treated with radical cystectomy (RC) at a single institution. MATERIALS AND METHODS: The present study included 1253 consecutive patients with BCa treated with RC and extended pelvic lymphadenectomy at a single institution from January 1990 to December 2014. Analysis of variance and χ(2) trend tests were used to report the clinical and pathologic characteristics of the cohort over time...
August 8, 2016: Clinical Genitourinary Cancer
Simone Porcelli, Lorenzo Pugliese, Enrico Rejc, Gaspare Pavei, Matteo Bonato, Michela Montorsi, Antonio La Torre, Letizia Rasica, Mauro Marzorati
It has been reported that nitrate supplementation can improve exercise performance. Most of the studies have used either beetroot juice or sodium nitrate as a supplement; there is lack of data on the potential ergogenic benefits of an increased dietary nitrate intake from a diet based on fruits and vegetables. Our aim was to assess whether a high-nitrate diet increases nitric oxide bioavailability and to evaluate the effects of this nutritional intervention on exercise performance. Seven healthy male subjects participated in a randomized cross-over study...
2016: Nutrients
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