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JOURNAL ARTICLE
K H Patel, K R Tringale, N Kim, L Boe, M Reyngold, A J Wu, M Zinovoy, P B Romesser, J Cuaron, E Pappou, M Nusrat, J Mulhall, C H Crane, C Hajj
PURPOSE/OBJECTIVE(S): Radiation therapy (RT) is commonly used in the treatment of locally advanced rectal cancer (LARC), but data on its impact on men's sexual health is limited. Given the rising incidence of rectal cancer in younger men, sexual function is an important quality of life factor. We hypothesized that men with LARC treated with RT would be at increased risk of sexual dysfunction compared to men who did not receive RT. MATERIALS/METHODS: This is a single institution retrospective analysis of outcomes of men ≤50 years diagnosed with LARC between 1999 and 2019...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#22
JOURNAL ARTICLE
Jess E Mulhall, Natalie A Trigg, Ilana R Bernstein, Amanda L Anderson, Heather C Murray, Petra Sipilä, Tessa Lord, John E Schjenken, Brett Nixon, David A Skerrett-Byrne
Residing between the testes and the vas deferens, the epididymis is a highly convoluted tubule whose unique luminal microenvironment is crucial for the functional maturation of spermatozoa. This microenvironment is created by the combined secretory and resorptive activity of the lining epididymal epithelium, including the release of extracellular vesicles (epididymosomes), which encapsulate fertility modulating proteins and a myriad of small non-coding RNAs (sncRNAs) that are destined for delivery to recipient sperm cells...
September 27, 2023: Proteomics
#23
JOURNAL ARTICLE
Matthew B Clements, Chasity B Walters, Kathleen A Lynch, Thomas M Atkinson, John P Mulhall, Tyrel J Starks, Andrew J Vickers, Sigrid V Carlsson
No abstract text is available yet for this article.
September 22, 2023: Archives of Sexual Behavior
#24
JOURNAL ARTICLE
Megan Mulhall, Kyle Wilson, Shiyan Yang, Jonny Kuo, Tracey Sletten, Clare Anderson, Mark E Howard, Shantha Rajaratnam, Michelle Magee, Allison Collins, Michael G Lenné
OBJECTIVE: examine the prevalence of driver distraction in naturalistic driving when implementing European New Car Assessment Program (Euro NCAP)-defined distraction behaviours. BACKGROUND: The 2023 introduction of Occupant Status monitoring (OSM) into Euro NCAP will accelerate uptake of Driver State Monitoring (DSM). Euro NCAP outlines distraction behaviours that DSM must detect to earn maximum safety points. Distraction behaviour prevalence and driver alerting and intervention frequency have yet to be examined in naturalistic driving...
August 20, 2023: Human Factors
#25
JOURNAL ARTICLE
Eric M Mulhall, Anant Gharpure, Rachel M Lee, Adrienne E Dubin, Jesse S Aaron, Kara L Marshall, Kathryn R Spencer, Michael A Reiche, Scott C Henderson, Teng-Leong Chew, Ardem Patapoutian
PIEZOs are mechanosensitive ion channels that convert force into chemoelectric signals1,2 and have essential roles in diverse physiological settings3 . In vitro studies have proposed that PIEZO channels transduce mechanical force through the deformation of extensive blades of transmembrane domains emanating from a central ion-conducting pore4-8 . However, little is known about how these channels interact with their native environment and which molecular movements underlie activation. Here we directly observe the conformational dynamics of the blades of individual PIEZO1 molecules in a cell using nanoscopic fluorescence imaging...
August 16, 2023: Nature
#26
JOURNAL ARTICLE
Andrea J Doyle, Clare Sullivan, Michelle O'Toole, Anna Tjin, Anastasija Simiceva, Naoise Collins, Paul Murphy, Michael J Anderson, Claire Mulhall, Claire Condron, Debra Nestel, Robert MacAulay, Nancy McNaughton, Frank Coffey, Walter Eppich
BACKGROUND: Providing feedback is a key aspect of simulated participants' (SPs) educational work. In teaching contexts, the ability to provide feedback to learners is central to their role. Suboptimal feedback practices may deny learners the valuable feedback they need to learn and improve. This scoping review systematically maps the evidence related to SPs' role as educators and identifies how SPs prepare for their role and feedback practices. METHODS: The authors conducted a scoping review and included a group of international stakeholders with experience and expertise in SP methodology...
August 8, 2023: Medical Teacher
#27
JOURNAL ARTICLE
David Shaw, Raquel Abad, Zahin Amin-Chowdhury, Adriana Bautista, Desiree Bennett, Karen Broughton, Bin Cao, Carlo Casanova, Eun Hwa Choi, Yiu-Wai Chu, Heike Claus, Juliana Coelho, Mary Corcoran, Simon Cottrell, Robert Cunney, Lize Cuypers, Tine Dalby, Heather Davies, Linda de Gouveia, Ala-Eddine Deghmane, Walter Demczuk, Stefanie Desmet, Mirian Domenech, Richard Drew, Mignon du Plessis, Carolina Duarte, Helga Erlendsdóttir, Norman K Fry, Kurt Fuursted, Thomas Hale, Desiree Henares, Birgitta Henriques-Normark, Markus Hilty, Steen Hoffmann, Hilary Humphreys, Margaret Ip, Susanne Jacobsson, Christopher Johnson, Jillian Johnston, Keith A Jolley, Aníbal Kawabata, Jana Kozakova, Karl G Kristinsson, Pavla Krizova, Alicja Kuch, Shamez Ladhani, Thiên-Trí Lâm, María Eugenia León, Laura Lindholm, David Litt, Martin C J Maiden, Irene Martin, Delphine Martiny, Wesley Mattheus, Noel D McCarthy, Mary Meehan, Susan Meiring, Paula Mölling, Eva Morfeldt, Julie Morgan, Robert Mulhall, Carmen Muñoz-Almagro, David Murdoch, Joy Murphy, Martin Musilek, Alexandre Mzabi, Ludmila Novakova, Shahin Oftadeh, Amaresh Perez-Argüello, Maria Pérez-Vázquez, Monique Perrin, Malorie Perry, Benoit Prevost, Maria Roberts, Assaf Rokney, Merav Ron, Olga Marina Sanabria, Kevin J Scott, Carmen Sheppard, Lotta Siira, Vitali Sintchenko, Anna Skoczyńska, Monica Sloan, Hans-Christian Slotved, Andrew J Smith, Anneke Steens, Muhamed-Kheir Taha, Maija Toropainen, Georgina Tzanakaki, Anni Vainio, Mark P G van der Linden, Nina M van Sorge, Emmanuelle Varon, Sandra Vohrnova, Anne von Gottberg, Jose Yuste, Rosemeire Zanella, Fei Zhou, Angela B Brueggemann
BACKGROUND: The Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of the COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and Streptococcus agalactiae. We aimed to analyse the incidence and distribution of these diseases during the first 2 years of the COVID-19 pandemic compared to the 2 years preceding the pandemic. METHODS: For this prospective analysis, laboratories in 30 countries and territories representing five continents submitted surveillance data from Jan 1, 2018, to Jan 2, 2022, to private projects within databases in PubMLST...
July 27, 2023: The Lancet. Digital health
#28
JOURNAL ARTICLE
Christina Farr Zuend, Alana Lamont, Laura Noel-Romas, Samantha Knodel, Kenzie Birse, Kateryna Kratzer, Peter McQueen, Michelle Perner, Hossaena Ayele, Sarah Mutch, Alicia R Berard, John J Schellenberg, Faruk Senturk, Stuart McCorrister, Garrett Westmacott, Fran Mulhall, Bonnie Sandberg, Adelicia Yu, Margaret Burnett, Vanessa Poliquin, Adam D Burgener
BACKGROUND: Cervicovaginal inflammation has been linked to negative reproductive health outcomes including the acquisition of HIV, other sexually transmitted infections, and cervical carcinogenesis. While changes to the vaginal microbiome have been linked to genital inflammation, the molecular relationships between the functional components of the microbiome with cervical immunology in the reproductive tract are understudied, limiting our understanding of mucosal biology that may be important for reproductive health...
July 25, 2023: Microbiome
#29
JOURNAL ARTICLE
Nicola McCleary, Laura Desveaux, Justin Presseau, Catherine Reis, Holly O Witteman, Monica Taljaard, Stefanie Linklater, Kednapa Thavorn, Gail Dobell, Cara L Mulhall, Jonathan M C Lam, Jeremy M Grimshaw, Noah M Ivers
BACKGROUND: While audit & feedback (A&F) is an effective implementation intervention, the design elements which maximize effectiveness are unclear. Partnering with a healthcare quality advisory organization already delivering feedback, we conducted a pragmatic, 2 × 2 factorial, cluster-randomized trial to test the impact of variations in two factors: (A) the benchmark used for comparison and (B) information framing. An embedded process evaluation explored hypothesized mechanisms of effect...
May 10, 2023: Implementation Science: IS
#30
JOURNAL ARTICLE
Jose M Flores, Carolyn A Salter, John P Mulhall
No abstract text is available yet for this article.
April 27, 2023: Journal of Sexual Medicine
#31
JOURNAL ARTICLE
Maryna V Ivanchenko, Daniel M Hathaway, Alex J Klein, Bifeng Pan, Olga Strelkova, Pedro De-la-Torre, Xudong Wu, Cole W Peters, Eric M Mulhall, Kevin T Booth, Corey Goldstein, Joseph Brower, Marcos Sotomayor, Artur A Indzhykulian, David P Corey
Usher syndrome type 1 F (USH1F), caused by mutations in the protocadherin-15 gene (PCDH15), is characterized by congenital deafness, lack of balance, and progressive blindness. In hair cells, the receptor cells of the inner ear, PCDH15 is a component of tip links, fine filaments which pull open mechanosensory transduction channels. A simple gene addition therapy for USH1F is challenging because the PCDH15 coding sequence is too large for adeno-associated virus (AAV) vectors. We use rational, structure-based design to engineer mini-PCDH15s in which 3-5 of the 11 extracellular cadherin repeats are deleted, but which still bind a partner protein...
April 26, 2023: Nature Communications
#32
JOURNAL ARTICLE
Randall Li, Daniela Wittmann, Christian J Nelson, Carolyn A Salter, John P Mulhall, Nataliya Byrne, Tatiana Sanchez Nolasco, Marina Ness, Natasha Gupta, Caroline Cassidy, Theodore Crisostomo-Wynne, Stacy Loeb
BACKGROUND: Prostate cancer (PCa) and its treatment can have significant and pervasive sexual side effects for patients and their partners; however, partner needs are not well understood, and most resources do not incorporate partner priorities. AIM: Our objective was to perform a qualitative study to identify unmet sexual needs of patients and female partners after PCa diagnosis. METHODS: We conducted a qualitative study of posts to the Inspire Us TOO Prostate Cancer Online Support and Discussion Community...
December 1, 2022: Journal of Sexual Medicine
#33
JOURNAL ARTICLE
Sinead Lambe, Jessica C Bird, Bao Sheng Loe, Laina Rosebrock, Thomas Kabir, Ariane Petit, Sophie Mulhall, Lucy Jenner, Charlotte Aynsworth, Elizabeth Murphy, Julia Jones, Rosie Powling, Kate Chapman, Robert Dudley, Anthony Morrison, Eileen O Regan, Ly-Mee Yu, David Clark, Felicity Waite, Daniel Freeman
BACKGROUND: Agoraphobic avoidance of everyday situations is a common feature in many mental health disorders. Avoidance can be due to a variety of fears, including concerns about negative social evaluation, panicking, and harm from others. The result is inactivity and isolation. Behavioural avoidance tasks (BATs) provide an objective assessment of avoidance and in situ anxiety but are challenging to administer and lack standardisation. Our aim was to draw on the principles of BATs to develop a self-report measure of agoraphobia symptoms...
March 2023: Psychological Medicine
#34
JOURNAL ARTICLE
Natasha Gupta, Laura Zebib, Daniela Wittmann, Christian J Nelson, Carolyn A Salter, John P Mulhall, Nataliya Byrne, Tatiana Sanchez Nolasco, Stacy Loeb
BACKGROUND: Prostate cancer (PCa) and its treatments can have a significant negative impact on the sexual health of survivors and couples, but few studies have specifically examined the impact of PCa-related sexual dysfunction on female partners of survivors. AIM: Our objective was to perform a qualitative study to comprehensively characterize female partners' perceptions of the implications of PCa on their sex lives, as well as partners' sexual health concerns and unmet needs...
April 27, 2023: Journal of Sexual Medicine
#35
JOURNAL ARTICLE
Jose M Flores, Bruno Nascimento, Nahid Punjani, Carolyn A Salter, Helen L Bernie, Hisanori Taniguchi, Eduardo Miranda, Jean-Etienne Terrier, Elizabeth Schofield, Lawrence Jenkins, John P Mulhall
INTRODUCTION: Penile curvature is the most common abnormality that is observed by men with Peyronie's disease (PD). Collagenase Clostridium histolyticum (CCH) has become a standard treatment for PD patients. AIM: To identify predictor factors associated with improvements of penile curvature outcomes in men with PD treated with CCH. METHODS: We retrospectively collected the data of patients with PD treated with CCH up to 8 injections divided into 4 cycles between January 2014 and July 2020...
November 1, 2022: Journal of Sexual Medicine
#36
JOURNAL ARTICLE
Daniela Wittmann, Akanksha Mehta, Eilis McCaughan, Martha Faraday, Ashley Duby, Andrew Matthew, Luca Incrocci, Arthur Burnett, Christian J Nelson, Stacy Elliott, Bridget F Koontz, Sharon L Bober, Deborah McLeod, Paolo Capogrosso, Tet Yap, Celestia Higano, Stacy Loeb, Emily Capellari, Michael Glodé, Heather Goltz, Doug Howell, Michael Kirby, Nelson Bennett, Landon Trost, Phillip Odiyo Ouma, Run Wang, Carolyn Salter, Ted A Skolarus, John McPhail, Susan McPhail, Jan Brandon, Laurel L Northouse, Kellie Paich, Craig E Pollack, Jen Shifferd, Kim Erickson, John P Mulhall
BACKGROUND: Patients with prostate cancer suffer significant sexual dysfunction after treatment which negatively affects them and their partners psychologically, and strain their relationships. AIM: We convened an international panel with the aim of developing guidelines that will inform clinicians, patients and partners about the impact of prostate cancer therapies (PCT) on patients' and partners' sexual health, their relationships, and about biopsychosocial rehabilitation in prostate cancer (PC) survivorship...
November 1, 2022: Journal of Sexual Medicine
#37
RANDOMIZED CONTROLLED TRIAL
Lisa C Zuckerwise, Joseph C Mulhall, Jennifer L Thompson, Loveis A Jackson, Edwina O McNeill-Simaan, Sarah S Osmundson
BACKGROUND: Suboptimal treatment of postpartum pain is associated with persistent pain and postpartum depression. Multimodal analgesia can achieve superior pain relief and decreased opioid consumption after surgery. There is limited and conflicting data on abdominal support devices to reduce postoperative pain and opioid use after cesarean delivery. OBJECTIVE: This study aimed to examine whether the use of a panniculus elevation device decreases opioid use and improves postoperative pain after cesarean delivery...
May 2023: American journal of obstetrics & gynecology MFM
#38
JOURNAL ARTICLE
Eric M Mulhall, Rachel Lee, Adrienne E Dubin, Jesse Aaron, Michael Reiche, Anant Gharpure, Kara Marshall, Kathryn Spencer, Scott C Henderson, Teng-Leong Chew, Ardem Patapoutian
No abstract text is available yet for this article.
February 10, 2023: Biophysical Journal
#39
JOURNAL ARTICLE
Ke Wen, Matthew D Resch, Ryan Mazboudi, Hannah Mulhall Maasz, Jose M Galarza
Adenovirus based vectors are useful tools for vaccine development, gene therapy, and oncolytic virotherapy. Here we describe a novel approach for the genetic engineering of any portion of the adenovirus genome and the reconstruction of either fully replication competent or defective virions. This innovative strategy is rapid, effective and suitable for the manipulation of the entire genome broadening the spectrum of potential applications for the adenovirus system. Our strategy involved insertion of restriction enzyme recognition sequences absent in the native virus into the termini of the adenovirus genome in order to facilitate recovery...
2023: Frontiers in medical technology
#40
JOURNAL ARTICLE
Clare Sullivan, Andrea Jane Doyle, Michelle O'Toole, Claire Mulhall, Nancy McNaughton, Walter Eppich
PURPOSE: Despite the demonstrated value of simulated participant (SP) feedback, we are only beginning to understand how to optimize SPs' feedback practices for communication skills and strengthen their role as educators. SPs portray roles and engage in feedback practices to support simulated-based learning for communication skills training. SPs come to their role with diverse experiences, knowledge, and training, such as (a) professional actors, (b) lay people, and (c) health professions educators...
February 1, 2023: Medical Teacher
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