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https://www.readbyqxmd.com/read/28108685/a-tablet-based-multimedia-education-tool-improves-provider-and-subject-knowledge-of-inhaler-use-techniques
#1
Aaron M Mulhall, Muhammad A Zafar, Samantha Record, Herman Channell, Ralph J Panos
BACKGROUND: Although inhaled medications are effective therapies for COPD, many patients and providers use them incorrectly. METHODS: We recruited providers who prescribe inhalers or teach inhaler technique and assessed their use of metered-dose inhalers (MDIs), various dry powder inhalers (DPIs), and Respimat using predefined checklists. Then they watched tablet-based multimedia educational videos that demonstrated correct inhaler technique by a clinical pharmacist with teach-back from a patient and were re-evaluated...
February 2017: Respiratory Care
https://www.readbyqxmd.com/read/28032424/relationship-between-age-and-erectile-dysfunction-diagnosis-or-treatment-using-real-world-observational-data-in-the-usa
#2
John P Mulhall, Xuemei Luo, Kelly H Zou, Vera Stecher, Aaron Galaznik
AIMS: With self-reporting of erectile dysfunction (ED) in population-based surveys, men with ED may not represent men who are bothered sufficiently to seek an ED diagnosis and treatment. We used real-world observational data to assess: 1) the prevalence of ED diagnosis or treatment by age subgroups; and 2) the relationship of age with ED diagnosis or treatment after controlling for ED-related comorbidities in the USA. METHODS: This cross-sectional study used de-identified claims data (MarketScan(®) databases; primary analysis)...
December 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28004591/long-acting-muscarinic-antagonists-for-the-treatment-of-chronic-obstructive-pulmonary-disease-a-review-of-current-and-developing-drugs
#3
REVIEW
Mark A Mastrodicasa, Christopher A Droege, Aaron M Mulhall, Neil E Ernst, Ralph J Panos, Muhammad A Zafar
Long acting muscarinic receptor antagonists (LAMA) reverse airflow obstruction by antagonizing para-sympathetic bronchoconstricting effects within the airways. For years, tiotropium, has been the cornerstone LAMA for chronic obstructive pulmonary disease (COPD) management. Recently, new agents, aclidinium bromide, glycopyrronium bromide, and umeclidinium bromide, have been developed and introduced into clinical practice. Areas covered: This article reviews the clinical efficacy and adverse effects of currently available LAMAs in COPD treatment as well as developing LAMAs in early clinical trials and preclinical studies (V0162, TD-4208, CHF 5407, AZD9164, AZD8683, bencycloquidium)...
February 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/27969281/orgasme-retard%C3%A3-secondaire%C3%A2-causes-associations-et-facteurs-pr%C3%A3-dictifs
#4
J Terrier, P Teloken, C Nelson, J Mulhall
No abstract text is available yet for this article.
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27969277/quel-score-%C3%A2-%C3%A2-cut-off%C3%A2-%C3%A2-de-l%C3%A2-iief-ef-doit-on-utiliser-pour-d%C3%A3-finir-la-satisfaction-sexuelle-post-prostatectomie-radicale%C3%A2
#5
J Terrier, C Nelson, J Mulhall
No abstract text is available yet for this article.
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27969227/troubles-sensitifs-post-%C3%A2-%C3%A2-incision-patch%C3%A2-%C3%A2-pour-maladie-de-lapeyronie
#6
J Terrier, R Tal, J Mulhall
No abstract text is available yet for this article.
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27861718/effect-of-cognitively-stimulating-activities-on-symptom-management-of-delirium-superimposed-on-dementia-a-randomized-controlled-trial
#7
Ann Kolanowski, Donna Fick, Mark Litaker, Paula Mulhall, Linda Clare, Nikki Hill, Jacqueline Mogle, Malaz Boustani, David Gill, Andrea Yevchak-Sillner
OBJECTIVE: To determine whether cognitively stimulating activities would reduce duration and severity of delirium and improve cognitive and physical function to a greater extent than usual care. DESIGN: Single-blind randomized clinical trial. SETTING: Eight post-acute care (PAC) facilities. PARTICIPANTS: Community-dwelling older adults with dementia and delirium (N = 283). INTERVENTION: Research staff provided cognitively stimulating activities daily for up to 30 days...
December 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27665357/prostate-magnetic-resonance-imaging-findings-in-patients-treated-for-testosterone-deficiency-while-on-active-surveillance-for-low-risk-prostate-cancer
#8
Takeshi Hashimoto, Krishnan Rahul, Toshikazu Takeda, Nicole Benfante, John P Mulhall, Hedvig Hricak, James A Eastham, Hebert Alberto Vargas
OBJECTIVE: To investigate the multiparametric prostate magnetic resonance imaging (mpMRI) findings in patients treated with testosterone replacement therapy (TRT) while on active surveillance for low-risk prostate cancer. METHODS: We retrospectively reviewed 12 patients who underwent mpMRI before and after TRT while on active surveillance. Changes in serum testosterone level, prostate-specific antigen (PSA), prostate biopsy findings, prostate volume, and Prostate Imaging Reporting and Data System Version 2 (PI-RADSv2) score before and after TRT were summarized...
December 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27629899/resolution-of-a-protracted-serogroup-b-meningococcal-outbreak-with-whole-genome-sequencing-shows-interspecies-genetic-transfer
#9
Robert M Mulhall, Carina Brehony, Lois O'Connor, Kenneth Meyler, Keith A Jolley, James Bray, Desiree Bennett, Martin C J Maiden, Robert Cunney
A carriage study was undertaken (n = 112) to ascertain the prevalence of Neisseria spp. following the eighth case of invasive meningococcal disease in young children (5 to 46 months) and members of a large extended indigenous ethnic minority Traveller family (n = 123), typically associated with high-occupancy living conditions. Nested multilocus sequence typing (MLST) was employed for case specimen extracts. Isolates were genome sequenced and then were assembled de novo and deposited into the Bacterial Isolate Genome Sequencing Database (BIGSdb)...
December 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27627480/bilateral-diaphragmatic-paralysis-a-rare-complication-related-to-endoscopic-ultrasound-guided-celiac-plexus-neurolysis
#10
Aaron M Mulhall, Mitchell C Rashkin, Elsira M Pina
No abstract text is available yet for this article.
September 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27609932/pilot-testing-of-the-eit-4-bpsd-intervention
#11
Barbara Resnick, Ann Kolanowski, Kimberly Van Haitsma, Marie Boltz, Elizabeth Galik, Alice Bonner, Erin Vigne, Lauren Holtzman, Paula M Mulhall
Behavioral and psychological symptoms of dementia are common in nursing home residents, and the Centers for Medicare and Medicaid Services now require that nonpharmacological interventions be used as a first-line treatment. Few staff know how to implement these interventions. The purpose of this study was to pilot test an implementation strategy, Evidence Integration Triangle for Behavioral and Psychological Symptoms of Dementia (EIT-4-BPSD), which was developed to help staff integrate behavioral interventions into routine care...
November 2016: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27436075/translational-perspective-on-the-role-of-testosterone-in-sexual-function-and-dysfunction
#12
REVIEW
Carol A Podlasek, John Mulhall, Kelvin Davies, Christopher J Wingard, Johanna L Hannan, Trinity J Bivalacqua, Biljana Musicki, Mohit Khera, Nestor F González-Cadavid, Arthur L Burnett
INTRODUCTION: The biological importance of testosterone is generally accepted by the medical community; however, controversy focuses on its relevance to sexual function and the sexual response, and our understanding of the extent of its role in this area is evolving. AIM: To provide scientific evidence examining the role of testosterone at the cellular and molecular levels as it pertains to normal erectile physiology and the development of erectile dysfunction and to assist in guiding successful therapeutic interventions for androgen-dependent sexual dysfunction...
August 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27402022/stem-cells-display-a-donor-dependent-response-to-escalating-levels-of-growth-factor-release-from-extracellular-matrix-derived-scaffolds
#13
Henrique V Almeida, Kevin J Mulhall, Fergal J O'Brien, Daniel J Kelly
Numerous growth factor delivery systems have been developed for tissue engineering. However, little is known about how the dose of a specific protein will influence tissue regeneration, or how different patients will respond to altered levels of growth factor presentation. The objective of the present study was to assess stem cell chondrogenesis within extracellular-matrix (ECM)-derived scaffolds loaded with escalating levels of transforming growth factor (TGF)-β3. It was also sought to determine if stem cells display a donor-dependent response to different doses of TGF-β3, from low (5 ng) to high (200 ng), released from such scaffolds...
July 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27306454/judgments-of-nonverbal-behaviour-by-children-with-high-functioning-autism-spectrum-disorder-can-they-detect-signs-of-winning-and-losing-from-brief-video-clips
#14
Christian Ryan, Philip Furley, Kathleen Mulhall
Typically developing children are able to judge who is winning or losing from very short clips of video footage of behaviour between active match play across a number of sports. Inferences from "thin slices" (short video clips) allow participants to make complex judgments about the meaning of posture, gesture and body language. This study extends the use of the thin slice research paradigm to children with high-functioning autism spectrum disorder (ASD). We tested 38 children with ASD, in two age groups: 15 participants aged 5-8 years and 23 participants aged 9-13 years...
September 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27209182/challenges-in-testosterone-measurement-data-interpretation-and%C3%A2-methodological-appraisal-of-interventional-trials
#15
REVIEW
Landon W Trost, John P Mulhall
INTRODUCTION: Male hypogonadism is a common condition, with an increasing body of literature on diagnosis, implications, and management. Given the significant variability in testosterone (T) from a physiologic and assay perspective, a thorough understanding of factors affecting T values and study methodology is essential to interpret reported study outcomes appropriately. However, despite the large number of publications on T, there are no reference materials consolidating all relevant and potentially confounding factors necessary to interpret T studies appropriately...
July 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27188339/erectile-dysfunction
#16
REVIEW
Faysal A Yafi, Lawrence Jenkins, Maarten Albersen, Giovanni Corona, Andrea M Isidori, Shari Goldfarb, Mario Maggi, Christian J Nelson, Sharon Parish, Andrea Salonia, Ronny Tan, John P Mulhall, Wayne J G Hellstrom
Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices...
February 4, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27162191/conservative-therapy-is-an-effective-option-in-patients-with-localized-infection-after-penile-implant-surgery
#17
Mohamad Habous, Mohammed Farag, Ben Williamson, Osama Laban, Saad Mahmoud, Osama Abdelwahab, Mohamed Elkhouly, Usama Kamil, Saleh Binsaleh, Raanan Tal, David Ralph, John P Mulhall
INTRODUCTION: Traditionally, penile implant (PI) infections have been managed by removal with immediate or delayed replacement. Recently, interest has been focused on conservative therapy (CT) using antibiotic therapy. AIM: To investigate the success rate and predictive factors affecting the outcome of CT in PI infection patients. METHODS: Patients diagnosed with early, localized PI infection were considered candidates for CT. Exclusion criteria included temperature >37...
June 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27149061/providers-perspectives-on-case-management-of-a-healthy-start-program-a-qualitative-study
#18
Imelda K Moise, Peter F Mulhall
Although Healthy Start case managers recognized the benefits of case management for facilitating optimal service delivery to women and their families, structural factors impact effective implementation. This study investigated case managers' views of 1) the structural challenges faced in implementing case management for program participants, and 2) possible strategies to enhance case management in medical home settings. Two focus groups were conducted separately with case managers from the four program service sites to gain insight into these issues noted above...
2016: PloS One
https://www.readbyqxmd.com/read/27122004/genetic-and-environmental-factors-associated-with-delirium-severity-in-older-adults-with-dementia
#19
Lauren Massimo, Elizabeth Munoz, Nikki Hill, Jacqueline Mogle, Paula Mulhall, Corey T McMillan, Linda Clare, David Vandenbergh, Donna Fick, Ann Kolanowski
OBJECTIVE: To determine (1) whether delirium severity was associated with Apolipoprotein E (APOE) genotype status and occupational complexity, a measure of cognitive reserve, in individuals with delirium superimposed on dementia; and (2) whether decline in delirium severity was associated with these same factors over a post-acute care (PAC) stay. METHODS: Control group data (n = 142) from a completed randomized clinical trial were used to address the aims of the study...
May 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27114197/efficacy-of-continuous-dosing-of-tadalafil-once-daily-vs-tadalafil-on-demand-in-clinical-subgroups-of-men-with-erectile-dysfunction-a-descriptive-comparison-using-the-integrated-tadalafil-databases
#20
Gerald Brock, Xiao Ni, Matthias Oelke, John Mulhall, Matt Rosenberg, Allen Seftel, Deborah D'Souza, Jane Barry
INTRODUCTION: Various factors play a role in the development of erectile dysfunction (ED). AIM: To provide a descriptive comparison of erectile function response for tadalafil on-demand (PRN) and once-daily (OAD) dosing regimens in patients with common comorbid conditions, treatments, or risk factors that can be considered when treating ED. METHODS: In total, 17 PRN and 4 OAD placebo-controlled studies were included in the integrated database in these pooled analyses...
May 2016: Journal of Sexual Medicine
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