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Ann Kolanowski, Donna Fick, Mark Litaker, Paula Mulhall, Linda Clare, Nikki Hill, Jacqueline Mogle, Malaz Boustani, David Gill, Andrea Yevchak-Sillner
OBJECTIVE: To determine whether cognitively stimulating activities would reduce duration and severity of delirium and improve cognitive and physical function to a greater extent than usual care. DESIGN: Single-blind randomized clinical trial. SETTING: Eight post-acute care (PAC) facilities. PARTICIPANTS: Community-dwelling older adults with dementia and delirium (N = 283). INTERVENTION: Research staff provided cognitively stimulating activities daily for up to 30 days...
November 12, 2016: Journal of the American Geriatrics Society
Takeshi Hashimoto, Krishnan Rahul, Toshikazu Takeda, Nicole Benfante, John P Mulhall, Hedvig Hricak, James A Eastham, Hebert Alberto Vargas
OBJECTIVE: To investigate the multiparametric prostate magnetic resonance imaging (mpMRI) findings in patients treated with testosterone replacement therapy (TRT) while on active surveillance for low-risk prostate cancer. METHODS: We retrospectively reviewed 12 patients who underwent mpMRI before and after TRT while on active surveillance. Changes in serum testosterone level, prostate-specific antigen (PSA), prostate biopsy findings, prostate volume, and Prostate Imaging Reporting and Data System Version 2 (PI-RADSv2) score before and after TRT were summarized...
December 2016: Urologic Oncology
Robert M Mulhall, Carina Brehony, Lois O'Connor, Kenneth Meyler, Keith A Jolley, James Bray, Desiree Bennett, Martin C J Maiden, Robert Cunney
BACKGROUND: A carriage study was undertaken (n=112) to ascertain the prevalence Neisseria spp. following the eighth case of invasive meningococcal disease in young children (5-46 months) and members of a large extended indigenous ethnic minority Traveller family (n=123), typically associated with high occupancy living conditions. METHODS: Nested Multi Locus Sequence Typing (MLST) was employed for case specimen extracts. Isolates were genome sequenced, then assembled de novo and deposited into the Bacterial Isolate Genome Sequencing database (BIGSdb)...
September 14, 2016: Journal of Clinical Microbiology
Aaron M Mulhall, Mitchell C Rashkin, Elsira M Pina
No abstract text is available yet for this article.
September 2016: Annals of the American Thoracic Society
Barbara Resnick, Ann Kolanowski, Kimberly Van Haitsma, Marie Boltz, Elizabeth Galik, Alice Bonner, Erin Vigne, Lauren Holtzman, Paula M Mulhall
Behavioral and psychological symptoms of dementia are common in nursing home residents, and the Centers for Medicare and Medicaid Services now require that nonpharmacological interventions be used as a first-line treatment. Few staff know how to implement these interventions. The purpose of this study was to pilot test an implementation strategy, Evidence Integration Triangle for Behavioral and Psychological Symptoms of Dementia (EIT-4-BPSD), which was developed to help staff integrate behavioral interventions into routine care...
November 2016: American Journal of Alzheimer's Disease and Other Dementias
Carol A Podlasek, John Mulhall, Kelvin Davies, Christopher J Wingard, Johanna L Hannan, Trinity J Bivalacqua, Biljana Musicki, Mohit Khera, Nestor F González-Cadavid, Arthur L Burnett
INTRODUCTION: The biological importance of testosterone is generally accepted by the medical community; however, controversy focuses on its relevance to sexual function and the sexual response, and our understanding of the extent of its role in this area is evolving. AIM: To provide scientific evidence examining the role of testosterone at the cellular and molecular levels as it pertains to normal erectile physiology and the development of erectile dysfunction and to assist in guiding successful therapeutic interventions for androgen-dependent sexual dysfunction...
August 2016: Journal of Sexual Medicine
Henrique V Almeida, Kevin J Mulhall, Fergal J O'Brien, Daniel J Kelly
Numerous growth factor delivery systems have been developed for tissue engineering. However, little is known about how the dose of a specific protein will influence tissue regeneration, or how different patients will respond to altered levels of growth factor presentation. The objective of the present study was to assess stem cell chondrogenesis within extracellular-matrix (ECM)-derived scaffolds loaded with escalating levels of transforming growth factor (TGF)-β3. It was also sought to determine if stem cells display a donor-dependent response to different doses of TGF-β3, from low (5 ng) to high (200 ng), released from such scaffolds...
July 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
Christian Ryan, Philip Furley, Kathleen Mulhall
Typically developing children are able to judge who is winning or losing from very short clips of video footage of behaviour between active match play across a number of sports. Inferences from "thin slices" (short video clips) allow participants to make complex judgments about the meaning of posture, gesture and body language. This study extends the use of the thin slice research paradigm to children with high-functioning autism spectrum disorder (ASD). We tested 38 children with ASD, in two age groups: 15 participants aged 5-8 years and 23 participants aged 9-13 years...
September 2016: Journal of Autism and Developmental Disorders
Landon W Trost, John P Mulhall
INTRODUCTION: Male hypogonadism is a common condition, with an increasing body of literature on diagnosis, implications, and management. Given the significant variability in testosterone (T) from a physiologic and assay perspective, a thorough understanding of factors affecting T values and study methodology is essential to interpret reported study outcomes appropriately. However, despite the large number of publications on T, there are no reference materials consolidating all relevant and potentially confounding factors necessary to interpret T studies appropriately...
July 2016: Journal of Sexual Medicine
Faysal A Yafi, Lawrence Jenkins, Maarten Albersen, Giovanni Corona, Andrea M Isidori, Shari Goldfarb, Mario Maggi, Christian J Nelson, Sharon Parish, Andrea Salonia, Ronny Tan, John P Mulhall, Wayne J G Hellstrom
Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices...
February 4, 2016: Nature Reviews. Disease Primers
Mohamad Habous, Mohammed Farag, Ben Williamson, Osama Laban, Saad Mahmoud, Osama Abdelwahab, Mohamed Elkhouly, Usama Kamil, Saleh Binsaleh, Raanan Tal, David Ralph, John P Mulhall
INTRODUCTION: Traditionally, penile implant (PI) infections have been managed by removal with immediate or delayed replacement. Recently, interest has been focused on conservative therapy (CT) using antibiotic therapy. AIM: To investigate the success rate and predictive factors affecting the outcome of CT in PI infection patients. METHODS: Patients diagnosed with early, localized PI infection were considered candidates for CT. Exclusion criteria included temperature >37...
June 2016: Journal of Sexual Medicine
Imelda K Moise, Peter F Mulhall
Although Healthy Start case managers recognized the benefits of case management for facilitating optimal service delivery to women and their families, structural factors impact effective implementation. This study investigated case managers' views of 1) the structural challenges faced in implementing case management for program participants, and 2) possible strategies to enhance case management in medical home settings. Two focus groups were conducted separately with case managers from the four program service sites to gain insight into these issues noted above...
2016: PloS One
Lauren Massimo, Elizabeth Munoz, Nikki Hill, Jacqueline Mogle, Paula Mulhall, Corey T McMillan, Linda Clare, David Vandenbergh, Donna Fick, Ann Kolanowski
OBJECTIVE: To determine (1) whether delirium severity was associated with Apolipoprotein E (APOE) genotype status and occupational complexity, a measure of cognitive reserve, in individuals with delirium superimposed on dementia; and (2) whether decline in delirium severity was associated with these same factors over a post-acute care (PAC) stay. METHODS: Control group data (n = 142) from a completed randomized clinical trial were used to address the aims of the study...
April 27, 2016: International Journal of Geriatric Psychiatry
Gerald Brock, Xiao Ni, Matthias Oelke, John Mulhall, Matt Rosenberg, Allen Seftel, Deborah D'Souza, Jane Barry
INTRODUCTION: Various factors play a role in the development of erectile dysfunction (ED). AIM: To provide a descriptive comparison of erectile function response for tadalafil on-demand (PRN) and once-daily (OAD) dosing regimens in patients with common comorbid conditions, treatments, or risk factors that can be considered when treating ED. METHODS: In total, 17 PRN and 4 OAD placebo-controlled studies were included in the integrated database in these pooled analyses...
May 2016: Journal of Sexual Medicine
Patrick Mulhall, Gerard Criner
Chronic obstructive pulmonary disease (COPD) affects roughly 10% of the global population and is growing in prevalence annually. COPD is characterized by progressive non-reversible narrowing of airways mainly due to cigarette smoking. Therapeutic interventions aimed at altering this progressive disease course can largely be grouped into pharmacological or non-pharmacological therapies. The focus of this paper is on the non-pharmacological aspects of COPD management, reviewing the current literature to provide an evidence-based management approach...
July 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
John P Mulhall, Gerald Brock, Matthias Oelke, Mikkel Fode, Kai A Probst, Carsten Henneges, Gianluca d'Anzeo, Andrea Rossi, Hartwig Büttner
INTRODUCTION AND AIM: The multicenter, randomized, double-blind, double-dummy, placebo-controlled REACTT trial suggested that treatment with tadalafil once daily (OaD) started early after bilateral nerve-sparing radical prostatectomy (nsRP) for prostate cancer may contribute to erectile function (EF)-recovery, which was predefined as achieving an International Index of Erectile Function (IIEF)-EF score ≥22. Here, we report descriptive post-hoc analyses, using the more strict definition for EF-recovery of returning back to the pre-surgery IIEF-EF-level ("back-to-baseline analysis")...
April 2016: Journal of Sexual Medicine
B P Mulhall, S T Wright, N De La Mata, D Allen, K Brown, B Dickson, M Grotowski, E Jackson, K Petoumenos, R Foster, T Read, D Russell, D J Smith, D J Templeton, C K Fairley, M G Law
OBJECTIVES: We established a subcohort of HIV-positive individuals from 10 sexual health clinics within the Australian HIV Observational Database (AHOD). The aim of this study was to assess demographic and other factors that might be associated with an incident sexually transmitted infection (STI). METHODS: The cohort follow-up was from March 2010 to March 2013, and included patients screened at least once for an STI. We used survival methods to determine time to first new and confirmed incident STI infection (chlamydia, gonorrhoea, syphilis or genital warts)...
September 2016: HIV Medicine
John P Mulhall, Gerald B Brock, Sidney Glina, Simin Baygani, Craig F Donatucci, Mario Maggi
INTRODUCTION: Controversy exists as to whether erectile response to phosphodiesterase type 5 inhibitors is compromised in men with low total testosterone (TT) levels. This is amplified by reports of improved response to phosphodiesterase type 5 inhibitor therapy after coadministration of testosterone replacement therapy in hypogonadal men unresponsive to phosphodiesterase type 5 inhibitors. AIM: To determine whether TT and luteinizing hormone levels influence efficacy of tadalafil for erectile dysfunction in men with concomitant lower urinary tract symptoms and benign prostatic hyperplasia...
May 2016: Journal of Sexual Medicine
Francesco Montorsi, Matthias Oelke, Carsten Henneges, Gerald Brock, Andrea Salonia, Gianluca d'Anzeo, Andrea Rossi, John P Mulhall, Hartwig Büttner
BACKGROUND: Understanding predictors for the recovery of erectile function (EF) after nerve-sparing radical prostatectomy (nsRP) might help clinicians and patients in preoperative counseling and expectation management of EF rehabilitation strategies. OBJECTIVE: To describe the effect of potential predictors on EF recovery after nsRP by post hoc decision-tree modeling of data from A Study of Tadalafil After Radical Prostatectomy (REACTT). DESIGN, SETTING, AND PARTICIPANTS: Randomized double-blind double-dummy placebo-controlled trial in 423 men aged <68 yr with adenocarcinoma of the prostate (Gleason ≤7, normal preoperative EF) who underwent nsRP at 50 centers from nine European countries and Canada...
September 2016: European Urology
Serkan Deveci, Geoffrey T Gotto, Byron Alex, Keith O'Brien, John P Mulhall
OBJECTIVE: To assess the understanding of patients, who had previously undergone radical prostatectomy (RP), about their postoperative sexual function, as clinical experience suggests that some RP patients have unrealistic expectations about their long-term sexual function. PATIENTS AND METHODS: Patients presenting within 3 months of their open RP or robot-assisted laparoscopic prostatectomy (RALP) were questioned about the sexual function information that they had received preoperatively...
October 2016: BJU International
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