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https://www.readbyqxmd.com/read/29601923/evaluation-and-management-of-testosterone-deficiency-aua-guideline
#1
John P Mulhall, Landon W Trost, Robert E Brannigan, Emily G Kurtz, J Bruce Redmon, Kelly A Chiles, Deborah J Lightner, Martin M Miner, M Hassan Murad, Christian J Nelson, Elizabeth A Platz, Lakshmi V Ramanathan, Ronald W Lewis
PURPOSE: There has been a marked increase in testosterone prescriptions in the past decade resulting in a growing need to give practicing clinicians proper guidance on the evaluation and management of the testosterone deficient patient. MATERIALS & METHODS: A systematic review utilized research from the Mayo Clinic Evidence Based Practice Center and additional supplementation by the authors. Evidence-based statements were based on body of evidence strength Grade A, B, or C and were designated as Strong, Moderate, and Conditional Recommendations with additional statements presented in the form of Clinical Principles or Expert Opinions...
March 27, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29589871/temporal-dynamics-of-circadian-phase-shifting-response-to-consecutive-night-shifts-in-healthcare-workers-role-of-light-dark-exposure
#2
Julia E Stone, Tracey L Sletten, Michelle Magee, Saranea Ganesan, Megan D Mulhall, Allison Collins, Mark Howard, Steven W Lockley, Shantha M W Rajaratnam
Night shift workers show highly variable rates of circadian adaptation. This study examined the relationship between light exposure patterns and magnitude of circadian phase resetting in response to night shift work. In 21 participants (nursing and medical staff in an Intensive Care Unit [ICU]) circadian phase was measured using 6-sulphatoxymelatonin (aMT6s) at baseline (day/evening shifts of days off) and after 3 to 4 consecutive night shifts. Daily light exposure was examined relative to individual circadian phase to quantify light intensity in the phase delay and phase advance portions of the light phase response curve (PRC)...
March 28, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29494351/sexual-satisfaction-changes-reported-by-men-after-their-partners-robotic-assisted-laparoscopic-sacrocolpopexies
#3
Patrick J Culligan, Sean Haughey, Christa Lewis, Jennifer Priestley, Charbel Salamon
OBJECTIVES: This study aimed to compare the preoperative and postoperative sexual satisfaction reported by male sexual partners of women undergoing surgical correction of pelvic organ prolapse. METHODS: This was a single-center prospective cohort study. Heterosexual, sexually active English-speaking couples in which the women were planning to undergo robotic-assisted laparoscopic sacrocolpopexy for correction of pelvic organ prolapse were eligible for enrollment in the study...
March 1, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29460994/sexual-habits-of-men-with-ed-who-take-phosphodiesterase-5-inhibitors-a-survey-conducted-in-7-countries
#4
John P Mulhall, Tarek A Hassan, James Rienow
INTRODUCTION: Western cultural perceptions that favour spontaneous sex may create unrealistic expectations for erectile dysfunction (ED) treatment. Little is known about how users of phosphodiesterase type 5 inhibitors (PDE5Is) plan sexual activity and timing of their preactivity PDE5I ingestion. Because various PDE5Is vary in their duration of action and dosage regimen, this may be an important consideration in selecting the optimal agent for the ED patient. AIM: To better understand the sexual habits of PDE5I users...
February 20, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29452098/features-of-chronic-obstructive-pulmonary-disease-as-predictors-of-lung-cancer
#5
Laurie L Carr, Sean Jacobson, David A Lynch, Marilyn G Foreman, Eric L Flenaugh, Craig P Hersh, Frank C Sciurba, David O Wilson, Jessica C Sieren, Patrick Mulhall, Victor Kim, C Matthew Kinsey, Russell P Bowler
BACKGROUND: Lung cancer is a leading cause of death and hospitalization for patients with chronic obstructive lung disease, (COPD); a detailed understanding of which clinical features of COPD increase risk is needed. METHODS: To identify clinical and imaging features of smokers, with and without COPD, that are associated with an increased risk of lung cancer, we performed a nested case-control study of COPDGene subjects with and without lung cancer, age 45-80, who smoked at least 10-pack years...
February 13, 2018: Chest
https://www.readbyqxmd.com/read/29421458/a-systematic-review-of-the-methodological-and-practical-challenges-of-undertaking-randomised-controlled-trials-with-cognitive-disability-populations
#6
REVIEW
Peter Mulhall, Laurence Taggart, Vivien Coates, Toni McAloon, Angela Hassiotis
Approximately 10% of the world's population have a cognitive disability. Cognitive disabilities can have a profound impact on a person's social, cognitive or mental functioning, requiring high levels of costly health and social support. Therefore, it is imperative that interventions and services received are based upon a sound evidence-base. For many interventions for this population, this evidence-base does not yet exist and there is a need for more Randomised Controlled Trials (RCTs). The process of conducting RCTs with disabled populations is fraught with methodological challenges...
January 29, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29371428/an-evolutionarily-conserved-gene-family-encodes-proton-selective-ion-channels
#7
Yu-Hsiang Tu, Alexander J Cooper, Bochuan Teng, Rui B Chang, Daniel J Artiga, Heather N Turner, Eric M Mulhall, Wenlei Ye, Andrew D Smith, Emily R Liman
Ion channels form the basis for cellular electrical signaling. Despite the scores of genetically identified ion channels selective for other monatomic ions, only one type of proton-selective ion channel has been found in eukaryotic cells. By comparative transcriptome analysis of mouse taste receptor cells, we identified Otopetrin1 (Otop1), a protein required for development of gravity-sensing otoconia in the vestibular system, as forming a proton-selective ion channel. We found that murine Otop1 is enriched in acid-detecting taste receptor cells and is required for their Zn2+-sensitive proton conductance...
January 25, 2018: Science
https://www.readbyqxmd.com/read/29336942/malleable-penile-implant-is-an-effective-therapeutic-option-in-men-with-peyronie-s-disease-and-erectile-dysfunction
#8
Mohamad Habous, Alaa Tealab, Mohammed Farag, Tarek Soliman, Ben Williamson, Saad Mahmoud, Amin Elserafy, Zenhom Mekawi, Abdallah Remeah, Mohammed Nassar, Osama Laban, Osama Abdelwahab, Saleh Binsaleh, Simone Giona, David Ralph, John Mulhall
BACKGROUND: The inflatable penile prosthesis (IPP) is typically the preferred implant for Peyronie's disease (PD) and malleable penile prostheses (MPPs) have been discouraged. AIMS: To evaluate the effectiveness and patient satisfaction of the MPP vs IPP in patients with PD. METHODS: Men with PD and erectile dysfunction who elected for penile implant surgery constituted the study population. Preoperatively, demographic and comorbidity parameters were recorded...
March 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29290217/variation-in-symptoms-of-depression-and-anxiety-in-midlife-women-by-menopausal-status
#9
Stephanie Mulhall, Ross Andel, Kaarin J Anstey
OBJECTIVES: To examine the association between menopausal status and the risk of symptoms of depression and anxiety in a community-based sample of Australian midlife women. STUDY DESIGN: Female participants (mean age 50.6±1.5) who were premenopausal (n=237), perimenopausal (n=249) or naturally postmenopausal (n=225) were drawn from the Personality and Total Health (PATH) Through Life Project, a longitudinal study. MAIN OUTCOME MEASURES: Symptoms of depression and anxiety were measured using the Goldberg Depression Scale and Goldberg Anxiety Scale...
February 2018: Maturitas
https://www.readbyqxmd.com/read/29180797/outcomes-of-variation-in-technique-and-variation-in-accuracy-of-measurement-in-penile-length-measurement
#10
Mohamad Habous, Gordon Muir, Tarek Soliman, Mohammed Farag, Ben Williamson, Saleh Binsaleh, Waleed Elhadek, Saad Mahmoud, Hussein Ibrahim, Osama Abdelwahab, Ziad Abdelrahman, Mohamed Abdelkader, Lawrence C Jenkins, John P Mulhall
Accurate data regarding the size of the erect penis is of great importance to several disciplines working with male patients, but little data exists on the best technique to measure penile length. While some previous small studies have suggested good correlation between stretched penile length, others have shown significant variability. Penile girth has been less well studied, and little data exist on the possible errors induced by differing observers and different techniques. Much of the published data report penile length measured from the penopubic skin junction-to-glans tip (STT) rather than pubic bone-to-tip (BTT)...
November 27, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29135495/prenatal-microrna-mir-200b-therapy-improves-nitrofen-induced-pulmonary-hypoplasia-associated-with-congenital-diaphragmatic-hernia
#11
Naghmeh Khoshgoo, Ramin Kholdebarin, Patricia Pereira-Terra, Thomas H Mahood, Landon Falk, Chelsea A Day, Barbara M Iwasiow, Fuqin Zhu, Drew Mulhall, Carly Fraser, Jorge Correia-Pinto, Richard Keijzer
OBJECTIVE: We aimed to evaluate the use of miR-200b as a prenatal transplacental therapy in the nitrofen rat model of abnormal lung development and congenital diaphragmatic hernia (CDH). BACKGROUND: Pulmonary hypoplasia (PH) and pulmonary hypertension determine mortality and morbidity in CDH babies. There is no safe medical prenatal treatment available. We previously discovered that higher miR-200b is associated with better survival in CDH babies. Here, we investigate the role of miR-200b in the nitrofen rat model of PH and CDH and evaluate its use as an in vivo prenatal therapy...
November 13, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29124870/defining-a-glycated-haemoglobin-hba1c-level-that-predicts-increased-risk-of-penile-implant-infection
#12
Mohamad Habous, Raanan Tal, Alaa Tealab, Tarek Soliman, Mohammed Nassar, Zenhom Mekawi, Saad Mahmoud, Osama Abdelwahab, Mohamed Elkhouly, Hatem Kamr, Abdallah Remeah, Saleh Binsaleh, David Ralph, John Mulhall
OBJECTIVES: To re-evaluate the role of diabetes mellitus (DM) as a risk factor for penile implant infection by exploring the association between glycated haemoglobin (HbA1c) levels and penile implant infection rates and to define a threshold value that predicts implant infection. PATIENTS AND METHODS: We conducted a multicentre prospective study including all patients undergoing penile implant surgery between 2009 and 2015. Preoperative, perioperative and postoperative management were identical for the entire cohort...
February 2018: BJU International
https://www.readbyqxmd.com/read/28969611/truenth-sexual-recovery-study-protocol-a-multi-institutional-collaborative-approach-to-developing-and-testing-a-web-based-intervention-for-couples-coping-with-the-side-effects-of-prostate-cancer-treatment-in-a-randomized-controlled-trial
#13
D Wittmann, A Mehta, L Northouse, R Dunn, T Braun, A Duby, L An, L Arab, R Bangs, S Bober, J Brandon, M Coward, M Dunn, M Galbraith, M Garcia, J Giblin, M Glode, B Koontz, A Lowe, S Mitchell, J Mulhall, C Nelson, K Paich, C Saigal, T Skolarus, J Stanford, T Walsh, C E Pollack
BACKGROUND: Over half of men who receive treatment for prostate suffer from a range of sexual problems that affect negatively their sexual health, sexual intimacy with their partners and their quality of life. In clinical practice, however, care for the sexual side effects of treatment is often suboptimal or unavailable. The goal of the current study is to test a web-based intervention to support the recovery of sexual intimacy of prostate cancer survivors and their partners after treatment...
October 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28965787/reporting-erectile-function-outcomes-after-radiation-therapy-for-prostate-cancer-challenges-in-data-interpretation
#14
Ruud C Wortel, Luca Incrocci, John P Mulhall
BACKGROUND: Choice of prostate cancer treatment is frequently influenced by the expected chance of treatment-induced side effects such as erectile dysfunction (ED). However, great discrepancy in cited ED rates exists in the contemporary radiation therapy literature. AIM: To analyze the reported ED rates and cause of discrepancies and explore the strengths and limitations in the literature on radiation-induced ED. METHODS: We performed a PubMed literature search and reviewed the literature on ED rates associated with external-beam radiotherapy and brachytherapy from the past 10 years...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28947026/manometry-optimized-positive-expiratory-pressure-mopep-in-excessive-dynamic-airway-collapse-edac
#15
Muhammad A Zafar, Aaron M Mulhall, William Eschenbacher, Ajay Kaul, Sadia Benzaquen, Ralph J Panos
BACKGROUND: Positive expiratory pressure(PEP) breathing modalities are commonly prescribed in obstructive lung diseases, however practical methods of airway pressures(AP) quantification for therapeutic efficacy are lacking. Excessive dynamic airway collapse(EDAC) is characterized by expiratory central airway collapse leading to dyspnea and poor quality of life(QoL), with limited therapeutic options. PURPOSE: To measure AP and exertional dyspnea in EDAC patients during normal breathing and with use of pursed-lip breathing(PLB), nasal PEP device(nPEP), and oral-PEP valve(oPEP) during rest and exercise using an Esophageal Manometer...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28851580/improved-recovery-of-erectile-function-in-younger-men-after-radical-prostatectomy-does-it-justify-immediate-surgery-in-low-risk-patients
#16
Justin K Lee, Daniel D Sjoberg, Mariam Imnadze Miller, Andrew J Vickers, John P Mulhall, Behfar Ehdaie
BACKGROUND: Although active surveillance is increasingly used for the management of low-risk prostate cancer, many eligible patients are still nonetheless subject to curative treatment. One argument for considering surgery rather than active surveillance is that the probability of postoperative recovery of erectile function is age dependent, that is, patients who delay surgery may lose the window of opportunity to recover erectile function after surgery. OBJECTIVE: To model erectile function over a 10-yr period for immediate surgery versus active surveillance...
January 2018: European Urology
https://www.readbyqxmd.com/read/28627740/biofabrication-of-soft-tissue-templates-for-engineering-the-bone-ligament-interface
#17
Ella Harris, Yurong Liu, Grainne Cunniffe, David Morrissey, Simon Carroll, Kevin Mulhall, Daniel J Kelly
Regenerating damaged tissue interfaces remains a significant clinical challenge, requiring recapitulation of the structure, composition, and function of the native enthesis. In the ligament-to-bone interface, this region transitions from ligament to fibrocartilage, to calcified cartilage and then to bone. This gradation in tissue types facilitates the transfer of load between soft and hard structures while minimizing stress concentrations at the interface. Previous attempts to engineer the ligament-bone interface have utilized various scaffold materials with an array of various cell types and/or biological cues...
October 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28607116/elimination-of-babesia-microti-is-dependent-on-intraerythrocytic-killing-and-cd4-t-cells
#18
Sini Skariah, Paul Arnaboldi, Raymond J Dattwyler, Ali A Sultan, Corey Gaylets, Odaelys Walwyn, Hannah Mulhall, Xia Wu, Soha R Dargham, Dana G Mordue
Babesiosis is a tick-borne zoonosis caused by protozoans of the genus Babesia, apicomplexan parasites that replicate within erythrocytes. However, unlike related Plasmodium species, the pathogenesis of Babesia infection remains poorly understood. The primary etiological agent of babesiosis in the United States is B. microti. In healthy individuals, tick-transmitted infection with Babesia causes no specific clinical manifestations, with many having no symptoms at all. However, even in asymptomatic people, a Babesia carriage state can be established that can last up to a year or more...
July 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28583341/exploring-the-optimal-erectile-function-domain-score-cutoff-that-defines-sexual-satisfaction-after-radical-prostatectomy
#19
Jean E Terrier, John P Mulhall, Christian J Nelson
INTRODUCTION: The International Index of Erectile Function (IIEF) is the gold standard validated instrument for defining erectile function (EF) and its response to treatment. The EF domain (EFD) contains six questions and is a sensitive and specific measurement of treatment-related changes in EF. The EFD score has been widely used as a primary assessment end point for clinical trials of EF recovery after radical prostatectomy (RP). Various EFD scores have been used to define functional erections...
June 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28567235/investigating-idiopathic-inflammatory-myopathy-initial-cross-speciality-experience-with-use-of-the-extended-myositis-antibody-panel
#20
Antoinette O'Connor, Jennifer Mulhall, Sinead M J Harney, John G Ryan, Grainne Murphy, Michael T Henry, Peter Annis, Vincent Tormey, Aisling M Ryan
The discovery of unique autoantibodies has informed and altered our approach to the diagnosis and management of the inflammatory myopathies. This study reports the initial clinical experience of use of the Extended Myositis Antibody (EMA) panel in the largest university teaching hospital in Ireland. We conducted a retrospective review of all patients who had serum samples tested for myositis specific antibodies and myositis associated antibodies from April 2014 to March 2015. A positive EMA panel was of significant clinical utility in facilitating decisions on appropriate investigations, and need for onward referral to other physicians...
April 6, 2017: Clinics and Practice
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