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https://www.readbyqxmd.com/read/29421458/a-systematic-review-of-the-methodological-and-practical-challenges-of-undertaking-randomised-controlled-trials-with-cognitive-disability-populations
#1
REVIEW
Peter Mulhall, Laurence Taggart, Vivien Coates, Toni McAloon, Angela Hassiotis
Approximately 10% of the world's population have a cognitive disability. Cognitive disabilities can have a profound impact on a person's social, cognitive or mental functioning, requiring high levels of costly health and social support. Therefore, it is imperative that interventions and services received are based upon a sound evidence-base. For many interventions for this population, this evidence-base does not yet exist and there is a need for more Randomised Controlled Trials (RCTs). The process of conducting RCTs with disabled populations is fraught with methodological challenges...
January 29, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29371428/an-evolutionarily-conserved-gene-family-encodes-proton-selective-ion-channels
#2
Yu-Hsiang Tu, Alexander J Cooper, Bochuan Teng, Rui B Chang, Daniel J Artiga, Heather N Turner, Eric M Mulhall, Wenlei Ye, Andrew D Smith, Emily R Liman
Ion channels form the basis for cellular electrical signaling. Despite the scores of genetically identified ion channels selective for other monatomic ions, only one type of proton-selective ion channel has been found in eukaryotic cells. By comparative transcriptome analysis of mouse taste receptor cells, we identified Otopetrin1 (Otop1), a protein required for development of gravity-sensing otoconia in the vestibular system, as forming a proton-selective ion channel. We found that murine Otop1 is enriched in acid-detecting taste receptor cells and is required for their Zn2+-sensitive proton conductance...
January 25, 2018: Science
https://www.readbyqxmd.com/read/29336942/malleable-penile-implant-is-an-effective-therapeutic-option-in-men-with-peyronie-s-disease-and-erectile-dysfunction
#3
Mohamad Habous, Alaa Tealab, Mohammed Farag, Tarek Soliman, Ben Williamson, Saad Mahmoud, Amin Elserafy, Zenhom Mekawi, Abdallah Remeah, Mohammed Nassar, Osama Laban, Osama Abdelwahab, Saleh Binsaleh, Simone Giona, David Ralph, John Mulhall
BACKGROUND: The inflatable penile prosthesis (IPP) is typically the preferred implant for Peyronie's disease (PD) and malleable penile prostheses (MPPs) have been discouraged. AIMS: To evaluate the effectiveness and patient satisfaction of the MPP vs IPP in patients with PD. METHODS: Men with PD and erectile dysfunction who elected for penile implant surgery constituted the study population. Preoperatively, demographic and comorbidity parameters were recorded...
January 11, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29290217/variation-in-symptoms-of-depression-and-anxiety-in-midlife-women-by-menopausal-status
#4
Stephanie Mulhall, Ross Andel, Kaarin J Anstey
OBJECTIVES: To examine the association between menopausal status and the risk of symptoms of depression and anxiety in a community-based sample of Australian midlife women. STUDY DESIGN: Female participants (mean age 50.6±1.5) who were premenopausal (n=237), perimenopausal (n=249) or naturally postmenopausal (n=225) were drawn from the Personality and Total Health (PATH) Through Life Project, a longitudinal study. MAIN OUTCOME MEASURES: Symptoms of depression and anxiety were measured using the Goldberg Depression Scale and Goldberg Anxiety Scale...
February 2018: Maturitas
https://www.readbyqxmd.com/read/29180797/outcomes-of-variation-in-technique-and-variation-in-accuracy-of-measurement-in-penile-length-measurement
#5
Mohamad Habous, Gordon Muir, Tarek Soliman, Mohammed Farag, Ben Williamson, Saleh Binsaleh, Waleed Elhadek, Saad Mahmoud, Hussein Ibrahim, Osama Abdelwahab, Ziad Abdelrahman, Mohamed Abdelkader, Lawrence C Jenkins, John P Mulhall
Accurate data regarding the size of the erect penis is of great importance to several disciplines working with male patients, but little data exists on the best technique to measure penile length. While some previous small studies have suggested good correlation between stretched penile length, others have shown significant variability. Penile girth has been less well studied, and little data exist on the possible errors induced by differing observers and different techniques. Much of the published data report penile length measured from the penopubic skin junction-to-glans tip (STT) rather than pubic bone-to-tip (BTT)...
November 27, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29135495/prenatal-microrna-mir-200b-therapy-improves-nitrofen-induced-pulmonary-hypoplasia-associated-with-congenital-diaphragmatic-hernia
#6
Naghmeh Khoshgoo, Ramin Kholdebarin, Patricia Pereira-Terra, Thomas H Mahood, Landon Falk, Chelsea A Day, Barbara M Iwasiow, Fuqin Zhu, Drew Mulhall, Carly Fraser, Jorge Correia-Pinto, Richard Keijzer
OBJECTIVE: We aimed to evaluate the use of miR-200b as a prenatal transplacental therapy in the nitrofen rat model of abnormal lung development and congenital diaphragmatic hernia (CDH). BACKGROUND: Pulmonary hypoplasia (PH) and pulmonary hypertension determine mortality and morbidity in CDH babies. There is no safe medical prenatal treatment available. We previously discovered that higher miR-200b is associated with better survival in CDH babies. Here, we investigate the role of miR-200b in the nitrofen rat model of PH and CDH and evaluate its use as an in vivo prenatal therapy...
November 13, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29124870/defining-a-hba1c-value-that-predicts-increased-risk-of-penile-implant-infection
#7
Mohamad Habous, Raanan Tal, Tarek Soliman, Alaa Tealab, Mohammed Nassar, Zenhom Mekawi, Saad Mahmoud, Osama Abdelwahab, Mohamed Elkhouly, Hatem Kamr, Abdallah Remeah, Saleh Binsaleh, David Ralph, John Mulhall
OBJECTIVES: To explore the association between HbA1C level and penile implant infection rates and to define a cut-off value that predicted implant infection. PATIENTS AND METHODS: A multi center prospective study included all patients undergoing penile implant surgery between 2009-15. Preoperative, perioperative and postoperative management were identical for the entire cohort. Univariate analysis was performed to define predictors of implant infection. HbA1c levels were analyzed as a continuous variable and sequential analysis was conducted utilizing 0...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/28969611/truenth-sexual-recovery-study-protocol-a-multi-institutional-collaborative-approach-to-developing-and-testing-a-web-based-intervention-for-couples-coping-with-the-side-effects-of-prostate-cancer-treatment-in-a-randomized-controlled-trial
#8
D Wittmann, A Mehta, L Northouse, R Dunn, T Braun, A Duby, L An, L Arab, R Bangs, S Bober, J Brandon, M Coward, M Dunn, M Galbraith, M Garcia, J Giblin, M Glode, B Koontz, A Lowe, S Mitchell, J Mulhall, C Nelson, K Paich, C Saigal, T Skolarus, J Stanford, T Walsh, C E Pollack
BACKGROUND: Over half of men who receive treatment for prostate suffer from a range of sexual problems that affect negatively their sexual health, sexual intimacy with their partners and their quality of life. In clinical practice, however, care for the sexual side effects of treatment is often suboptimal or unavailable. The goal of the current study is to test a web-based intervention to support the recovery of sexual intimacy of prostate cancer survivors and their partners after treatment...
October 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28965787/reporting-erectile-function-outcomes-after-radiation-therapy-for-prostate-cancer-challenges-in-data-interpretation
#9
Ruud C Wortel, Luca Incrocci, John P Mulhall
BACKGROUND: Choice of prostate cancer treatment is frequently influenced by the expected chance of treatment-induced side effects such as erectile dysfunction (ED). However, great discrepancy in cited ED rates exists in the contemporary radiation therapy literature. AIM: To analyze the reported ED rates and cause of discrepancies and explore the strengths and limitations in the literature on radiation-induced ED. METHODS: We performed a PubMed literature search and reviewed the literature on ED rates associated with external-beam radiotherapy and brachytherapy from the past 10 years...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28947026/manometry-optimized-positive-expiratory-pressure-mopep-in-excessive-dynamic-airway-collapse-edac
#10
Muhammad A Zafar, Aaron M Mulhall, William Eschenbacher, Ajay Kaul, Sadia Benzaquen, Ralph J Panos
BACKGROUND: Positive expiratory pressure(PEP) breathing modalities are commonly prescribed in obstructive lung diseases, however practical methods of airway pressures(AP) quantification for therapeutic efficacy are lacking. Excessive dynamic airway collapse(EDAC) is characterized by expiratory central airway collapse leading to dyspnea and poor quality of life(QoL), with limited therapeutic options. PURPOSE: To measure AP and exertional dyspnea in EDAC patients during normal breathing and with use of pursed-lip breathing(PLB), nasal PEP device(nPEP), and oral-PEP valve(oPEP) during rest and exercise using an Esophageal Manometer...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28851580/improved-recovery-of-erectile-function-in-younger-men-after-radical-prostatectomy-does-it-justify-immediate-surgery-in-low-risk-patients
#11
Justin K Lee, Daniel D Sjoberg, Mariam Imnadze Miller, Andrew J Vickers, John P Mulhall, Behfar Ehdaie
BACKGROUND: Although active surveillance is increasingly used for the management of low-risk prostate cancer, many eligible patients are still nonetheless subject to curative treatment. One argument for considering surgery rather than active surveillance is that the probability of postoperative recovery of erectile function is age dependent, that is, patients who delay surgery may lose the window of opportunity to recover erectile function after surgery. OBJECTIVE: To model erectile function over a 10-yr period for immediate surgery versus active surveillance...
August 26, 2017: European Urology
https://www.readbyqxmd.com/read/28627740/biofabrication-of-soft-tissue-templates-for-engineering-the-bone-ligament-interface
#12
Ella Harris, Yurong Liu, Grainne Cunniffe, David Morrissey, Simon Carroll, Kevin Mulhall, Daniel J Kelly
Regenerating damaged tissue interfaces remains a significant clinical challenge, requiring recapitulation of the structure, composition, and function of the native enthesis. In the ligament-to-bone interface, this region transitions from ligament to fibrocartilage, to calcified cartilage and then to bone. This gradation in tissue types facilitates the transfer of load between soft and hard structures while minimizing stress concentrations at the interface. Previous attempts to engineer the ligament-bone interface have utilized various scaffold materials with an array of various cell types and/or biological cues...
October 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28607116/elimination-of-babesia-microti-is-dependent-on-intraerythrocytic-killing-and-cd4-t-cells
#13
Sini Skariah, Paul Arnaboldi, Raymond J Dattwyler, Ali A Sultan, Corey Gaylets, Odaelys Walwyn, Hannah Mulhall, Xia Wu, Soha R Dargham, Dana G Mordue
Babesiosis is a tick-borne zoonosis caused by protozoans of the genus Babesia, apicomplexan parasites that replicate within erythrocytes. However, unlike related Plasmodium species, the pathogenesis of Babesia infection remains poorly understood. The primary etiological agent of babesiosis in the United States is B. microti. In healthy individuals, tick-transmitted infection with Babesia causes no specific clinical manifestations, with many having no symptoms at all. However, even in asymptomatic people, a Babesia carriage state can be established that can last up to a year or more...
July 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28583341/exploring-the-optimal-erectile-function-domain-score-cutoff-that-defines-sexual-satisfaction-after-radical-prostatectomy
#14
Jean E Terrier, John P Mulhall, Christian J Nelson
INTRODUCTION: The International Index of Erectile Function (IIEF) is the gold standard validated instrument for defining erectile function (EF) and its response to treatment. The EF domain (EFD) contains six questions and is a sensitive and specific measurement of treatment-related changes in EF. The EFD score has been widely used as a primary assessment end point for clinical trials of EF recovery after radical prostatectomy (RP). Various EFD scores have been used to define functional erections...
June 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28567235/investigating-idiopathic-inflammatory-myopathy-initial-cross-speciality-experience-with-use-of-the-extended-myositis-antibody-panel
#15
Antoinette O'Connor, Jennifer Mulhall, Sinead M J Harney, John G Ryan, Grainne Murphy, Michael T Henry, Peter Annis, Vincent Tormey, Aisling M Ryan
The discovery of unique autoantibodies has informed and altered our approach to the diagnosis and management of the inflammatory myopathies. This study reports the initial clinical experience of use of the Extended Myositis Antibody (EMA) panel in the largest university teaching hospital in Ireland. We conducted a retrospective review of all patients who had serum samples tested for myositis specific antibodies and myositis associated antibodies from April 2014 to March 2015. A positive EMA panel was of significant clinical utility in facilitating decisions on appropriate investigations, and need for onward referral to other physicians...
April 6, 2017: Clinics and Practice
https://www.readbyqxmd.com/read/28469551/npy1-receptor-agonist-modulates-development-of-depressive-like-behavior-and-gene-expression-in-hypothalamus-in-sps-rodent-ptsd-model
#16
Lidia Serova, Hannah Mulhall, Esther Sabban
Delivery of neuropeptide Y (NPY) to the brain by intranasal infusion soon after traumatic stress has shown therapeutic potential, and prevented development of many behavioral and neuroendocrine impairments in the single prolonged stress (SPS) animal model of PTSD. Therefore, we examined whether the Y1R preferring agonist [Leu(31)Pro(34)]NPY is sufficient to prevent development of SPS induced depressive-like behavioral changes, and hypothalamic gene expression as obtained with intranasal NPY intervention. Male Sprague-Dawely rats were given intranasal infusion of either NPY (150 μg/rat), a low (68 μg /rat), or high (132 μg/rat) dose of [Leu(31)Pro(34)]NPY or vehicle immediately following the last SPS stressor, left undisturbed for 1 week and then tested for depressive-like behavior together with naïve unstressed controls...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28460995/three-dimensional-photography-for-quantitative-assessment-of-penile-volume-loss-deformities-in-peyronie-s-disease
#17
Ezra J Margolin, Carrie M Mlynarczyk, John P Mulhall, Doron S Stember, Peter J Stahl
BACKGROUND: Non-curvature penile deformities are prevalent and bothersome manifestations of Peyronie's disease (PD), but the quantitative metrics that are currently used to describe these deformities are inadequate and non-standardized, presenting a barrier to clinical research and patient care. AIM: To introduce erect penile volume (EPV) and percentage of erect penile volume loss (percent EPVL) as novel metrics that provide detailed quantitative information about non-curvature penile deformities and to study the feasibility and reliability of three-dimensional (3D) photography for measurement of quantitative penile parameters...
June 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28108685/a-tablet-based-multimedia-education-tool-improves-provider-and-subject-knowledge-of-inhaler-use-techniques
#18
Aaron M Mulhall, Muhammad A Zafar, Samantha Record, Herman Channell, Ralph J Panos
BACKGROUND: Although inhaled medications are effective therapies for COPD, many patients and providers use them incorrectly. METHODS: We recruited providers who prescribe inhalers or teach inhaler technique and assessed their use of metered-dose inhalers (MDIs), various dry powder inhalers (DPIs), and Respimat using predefined checklists. Then they watched tablet-based multimedia educational videos that demonstrated correct inhaler technique by a clinical pharmacist with teach-back from a patient and were re-evaluated...
February 2017: Respiratory Care
https://www.readbyqxmd.com/read/28032424/relationship-between-age-and-erectile-dysfunction-diagnosis-or-treatment-using-real-world-observational-data-in-the-usa
#19
John P Mulhall, Xuemei Luo, Kelly H Zou, Vera Stecher, Aaron Galaznik
AIMS: With self-reporting of erectile dysfunction (ED) in population-based surveys, men with ED may not represent men who are bothered sufficiently to seek an ED diagnosis and treatment. We used real-world observational data to assess: 1) the prevalence of ED diagnosis or treatment by age subgroups; and 2) the relationship of age with ED diagnosis or treatment after controlling for ED-related comorbidities in the USA. METHODS: This cross-sectional study used de-identified claims data (MarketScan(®) databases; primary analysis)...
December 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28004591/long-acting-muscarinic-antagonists-for-the-treatment-of-chronic-obstructive-pulmonary-disease-a-review-of-current-and-developing-drugs
#20
REVIEW
Mark A Mastrodicasa, Christopher A Droege, Aaron M Mulhall, Neil E Ernst, Ralph J Panos, Muhammad A Zafar
Long acting muscarinic receptor antagonists (LAMA) reverse airflow obstruction by antagonizing para-sympathetic bronchoconstricting effects within the airways. For years, tiotropium, has been the cornerstone LAMA for chronic obstructive pulmonary disease (COPD) management. Recently, new agents, aclidinium bromide, glycopyrronium bromide, and umeclidinium bromide, have been developed and introduced into clinical practice. Areas covered: This article reviews the clinical efficacy and adverse effects of currently available LAMAs in COPD treatment as well as developing LAMAs in early clinical trials and preclinical studies (V0162, TD-4208, CHF 5407, AZD9164, AZD8683, bencycloquidium)...
February 2017: Expert Opinion on Investigational Drugs
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