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Andrew C Faust, Emily Guy, Nidhu Baby, Anthony Ortegon
BACKGROUND: Methemoglobinemia is a well-recognized adverse drug reaction related to the use of certain local anesthetic agents. The mainstay of treatment for methemoglobinemia is i.v. methylene blue, along with provision of supplemental oxygen; however, methylene blue is listed as a category X teratogen. This poses an issue should methemoglobinemia develop during pregnancy. CASE REPORT: A 35-year-old, 20-week and 5-day gravid female was transferred from an outpatient oral surgeon's office for hypoxia...
March 5, 2018: Journal of Emergency Medicine
Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Carmen Hierro-Bujalance, Esperanza Ortegon, Eleanor Pickett, Rosemary Jackson, Fernando Hernandez-Pacho, Tara Spires-Jones, Monica Garcia-Alloza
Type 2 diabetes (T2D) is an important risk factor to suffer dementia, being Alzheimer's disease (AD) as the most common form. Both AD and T2D are closely related to aging and with a growing elderly population it might be of relevance to explore new therapeutic approaches that may slow or prevent central complications associated with metabolic disorders. Therefore, we propose the use of the antidiabetic polypill (PP), a pharmacological cocktail, commonly used by T2D patients that include metformin, aspirin, simvastatin, and an angiotensin-converting enzyme inhibitor...
December 9, 2017: Molecular Neurobiology
Joanne M Leach, Susan E Lee, Christopher T Boyko, Claire J Coulton, Rachel Cooper, Nicholas Smith, Hélène Joffe, Milena Büchs, James D Hale, Jonathan P Sadler, Peter A Braithwaite, Luke S Blunden, Valeria De Laurentiis, Dexter V L Hunt, AbuBakr S Bahaj, Katie Barnes, Christopher J Bouch, Leonidas Bourikas, Marianna Cavada, Andrew Chilvers, Stephen J Clune, Brian Collins, Ellie Cosgrave, Nick Dunn, Jane Falkingham, Patrick James, Corina Kwami, Martin Locret-Collet, Francesca Medda, Adriana Ortegon, Serena Pollastri, Cosmin Popan, Katerina Psarikidou, Nick Tyler, John Urry, Yue Wu, Victoria Zeeb, Chris D F Rogers
This data article presents the UK City LIFE1 data set for the city of Birmingham, UK. UK City LIFE1 is a new, comprehensive and holistic method for measuring the livable sustainability performance of UK cities. The Birmingham data set comprises 346 indicators structured simultaneously (1) within a four-tier, outcome-based framework in order to aid in their interpretation (e.g., promote healthy living and healthy long lives, minimize energy use, uncouple economic vitality from CO2 emissions) and (2) thematically in order to complement government and disciplinary siloes (e...
December 2017: Data in Brief
Zeltia Torrecilla, Andrés Martínez-Lage, Alejandra Perina, Enrique González-Ortegón, Ana M González-Tizón
BACKGROUND: The maintenance of species and the promotion of speciation are closely related to chromosomal rearrangements throughout evolution. Decapoda represents the most species-rich order among crustaceans and, despite its ecological and economic importance, little is known about decapod karyology. We aim at cytogenetically characterizing two sympatric prawn species. RESULTS: Analysis of mitotic metaphases and meiotic diakinesis of the common prawn Palaemon serratus and the rockpool prawn P...
2017: Frontiers in Zoology
Joan Giménez, Ana Marçalo, Francisco Ramírez, Philippe Verborgh, Pauline Gauffier, Ruth Esteban, Lídia Nicolau, Enrique González-Ortegón, Francisco Baldó, César Vilas, José Vingada, Manuela G Forero, Renaud de Stephanis
The ecological role of species can vary among populations depending on local and regional differences in diet. This is particularly true for top predators such as the bottlenose dolphin (Tursiops truncatus), which exhibits a highly varied diet throughout its distribution range. Local dietary assessments are therefore critical to fully understand the role of this species within marine ecosystems, as well as its interaction with important ecosystem services such as fisheries. Here, we combined stomach content analyses (SCA) and stable isotope analyses (SIA) to describe bottlenose dolphins diet in the Gulf of Cadiz (North Atlantic Ocean)...
2017: PloS One
Lizeth Ortegón, Marcela Puentes-Herrera, Ivohne F Corrales, Jorge A Cortés
Healthcare-associated infections are a major problem in newborn infants, considering their high morbidity, mortality, and long-term sequelae. In preterm infants, it has been shown that skin and gastrointestinal tract colonization undergoes variations compared to healthy term infants, and that preterm infants are more exposed to nosocomial microorganisms given their higher probability of being admitted to the neonatal intensive care unit where they are cared for. This document reviews normal colonization, the changes observed during hospitalization, prematurity, and the potential role of chlorhexidine in the prevention of resistant microorganism transmission, as well as its side effects in newborn infants admitted to the neonatal intensive care unit...
February 1, 2017: Archivos Argentinos de Pediatría
Yohei Ohashi, Nicolas Soler, Miguel García Ortegón, Lufei Zhang, Marie L Kirsten, Olga Perisic, Glenn R Masson, John E Burke, Arjen J Jakobi, Apostolos A Apostolakis, Christopher M Johnson, Maki Ohashi, Nicholas T Ktistakis, Carsten Sachse, Roger L Williams
The phosphatidylinositol 3-kinase Vps34 is part of several protein complexes. The structural organization of heterotetrameric complexes is starting to emerge, but little is known about organization of additional accessory subunits that interact with these assemblies. Combining hydrogen-deuterium exchange mass spectrometry (HDX-MS), X-ray crystallography and electron microscopy (EM), we have characterized Atg38 and its human ortholog NRBF2, accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1-ATG14 (human)...
November 2016: Autophagy
Eduardo Ensaldo-Carrasco, Milton Fabian Suarez-Ortegon, Andrew Carson-Stevens, Kathrin Cresswell, Raman Bedi, Aziz Sheikh
BACKGROUND: There have been efforts to understand the epidemiology of iatrogenic harm in hospitals and primary care and to improve the safety of care provision. There has in contrast been very limited progress in relation to the safety of ambulatory dental care. OBJECTIVES: To provide a comprehensive overview of the range and frequencies of existing evidence on patient safety incidents and adverse events in ambulatory dentistry. METHODS: We searched MEDLINE and EMBASE for articles reporting events that could have or did result in unnecessary harm in ambulatory dental care...
September 8, 2016: Journal of Patient Safety
Milton Fabian Suárez-Ortegón, Stela McLachlan, Sarah H Wild, José Manuel Fernández-Real, Caroline Hayward, Ozren Polašek
The metabolic syndrome (MetS) is known to be associated with elevated serum ferritin levels. The possible association with other Fe markers has been less well studied. We aimed to investigate the cross-sectional association of soluble transferrin receptor (sTfR) and ferritin levels with the MetS components, insulin resistance and glycosylated Hb (HbA1C). The sample consisted of 725 adults, aged 19-93 years (284 men, 151 premenopausal and 290 postmenopausal women), from the Croatian island of Vis. Serum sTfR and ferritin levels were measured by immunoturbidimetry and electrochemiluminescence assays, respectively...
October 2016: British Journal of Nutrition
Fanny Concha Valdez, Clotilde Marín, Javier Flores Abuxapqui, Javier Escobedo Ortegón, Rocío Cañas, Manuel Sánchez Moreno
BACKGROUND: Chagas disease caused by Trypanosoma cruzi is endemic in Latin America. Human infection is mainly spread by Triatominae insects. Other forms of transmission are congenital, blood transfusion and organ transplantation. METHODS: Anti-T. cruzi antibodies were determined by enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) in 155 serum samples from mothers and their babies. Indirect immunofluorescence (IFA) and a commercial test were used to validate efficacy of a specific ELISA-iron-excreted superoxide dismutase assay...
July 2016: Pediatric Infectious Disease Journal
Elena Nieto, Miriam Hampel, Enrique González-Ortegón, Pilar Drake, Julián Blasco
Lethal and sublethal responses of the shrimp Atyaephyra desmarestii exposed to three pharmaceutical compounds, Diclofenac (DF), Ibuprofen (IB) and Carbamazepine (CBZ), individually and in mixtures, were evaluated under two temperature scenarios. LC50 (96h) values were obtained individually at 20° and 25°C. At 25°C, mortality in binary and ternary mixtures is higher than at 20°C. The toxicity of the mixtures was predicted on the basis of individual mortality data using two toxicity models: Concentration addition (CA) and Independent action (IA)...
August 5, 2016: Journal of Hazardous Materials
A Pech-May, G Peraza-Herrera, D A Moo-Llanes, J Escobedo-Ortegón, M Berzunza-Cruz, I Becker-Fauser, A C Montes DE Oca-Aguilar, E A Rebollar-Téllez
Localized cutaneous leishmaniasis represents a public health problem in many areas of Mexico, especially in the Yucatan Peninsula. An understanding of vector ecology and bionomics is of great importance in evaluations of the transmission dynamics of Leishmania parasites. A field study was conducted in the county of Calakmul, state of Campeche, during the period from November 2006 to March 2007. Phlebotomine sandfly vectors were sampled using Centers for Disease Control light traps, baited Disney traps and Shannon traps...
September 2016: Medical and Veterinary Entomology
Milton Fabian Suarez-Ortegón, Cecilia Aguilar-de Plata
BACKGROUND: Exploration of cardiometabolic alterations in the pre-adolescent stage is necessary to characterize possible patterns for matabolic syndrome (MetS) in the earliest stages of the life. However, defining specific cutoff points for metabolic and vascular markers represents a complex task in pre-adolescent populations. This study aimed to estimate the prevalence of MetS and its components in children aged 5-9 years old by using the MetS definition for adolescents with the lowest cut-off points, and evaluate its relationship with overweight and socio-demographic determinants...
November 2016: World Journal of Pediatrics: WJP
María José Aguilar Cordero, Alberto Ortegón Piñero, Laura Baena García, Jessica Pamela Noack Segovia, María Cristina Levet Hernández, Antonio Manuel Sánchez López
BACKGROUND: studies show that overweight and obesity are the result of a complex interaction between genetic and environmental factors that begins prenatally. In evidence of this relationship the potential impact of prenatal nutrition experience in the development of the endocrine and neuroendocrine systems that regulate energy balance, with special emphasis on leptin, an adipocytederived hormone. Different authors relate the risk of obesity with rapid weight gain in the first years of life...
December 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Cesar Garcias-Morales, David Ortegón-Reyna, Armando Ariza-Castolo
This paper reports the synthesis of a series of piperidones 1-8 by the Mannich reaction and analysis of their structures and conformations in solution by NMR and mass spectrometry. The six-membered rings in 2,4,6,8-tetraphenyl-3,7-diazabicyclo[3.3.1]nonan-9-ones, compounds 1 and 2, adopt a chair-boat conformation, while those in 2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9-ones, compounds 3-8, adopt a chair-chair conformation because of stereoelectronic effects. These stereoelectronic effects were analyzed by the (1) J C-H coupling constants, which were measured in the (13)C satellites of the (1)H NMR spectra obtained with the hetero-dqf pulse sequence...
2015: Beilstein Journal of Organic Chemistry
Milton Fabián Suárez-Ortegón, María Moreno, Alejandra Arbeláez, Gemma Xifra, Mildrey Mosquera, José María Moreno-Navarrete, Cecilia Aguilar-de Plata, Eduardo Esteve, Wifredo Ricart, José Manuel Fernández-Real
SCOPE: Very few studies have evaluated serum hepcidin in patients with type 2 diabetes and they have reported conflicting results. In addition, the effect of antidiabetic drugs on circulating hepcidin has not been explored so far. The aims of the study were to evaluate hepcidin concentrations and hepcidin/ferritin ratio in type 2 diabetes subjects and healthy non-diabetic controls and to evaluate the effect of metformin on hepcidin concentrations. METHODS AND RESULTS: Study 1: Cross-sectional multivariate study of 239 non-diabetic individuals and 65 people with type 2 diabetes...
December 2015: Molecular Nutrition & Food Research
Gloria Páez Ortegón, Fernando Muñoz Arboleda, Lucila Candela, Karim Tamoh, Javier Valdes-Abellan
Extensive application of vinasse, a subproduct from sugar cane plantations for bioethanol production, is currently taking place as a source of nutrients that forms part of agricultural management in different agroclimatic regions. Liquid vinasse composition is characterised by high variability of organic compounds and major ions, acid pH (4.7), high TDS concentration (117,416-599,400mgL(-1)) and elevated EC (14,350-64,099μScm(-1)). A large-scale sugar cane field application is taking place in Valle del Cauca (Colombia), where monitoring of soil, unsaturated zone and the aquifer underneath has been made since 2006 to evaluate possible impacts on three experimental plots...
January 1, 2016: Science of the Total Environment
Ricardo Antonio Agredo-Zúñiga, Cecilia Aguilar-de Plata, Milton Fabian Suárez-Ortegón
Very few large studies in Latin America have evaluated the association between waist:height ratio (W-HtR) and cardiometabolic risk in children and adolescents. Further, multivariable analyses verifying the independence of located subcutaneous fat have not been conducted so far. The aim of this study was to evaluate the associations of W-HtR and waist circumference (WC) with metabolic syndrome abnormalities and high LDL-cholesterol levels in schooled adolescents before and after adjusting for trunk skinfolds and BMI...
September 14, 2015: British Journal of Nutrition
Milton Fabian Suárez-Ortegón, Alejandra Arbeláez, Mildrey Mosquera, José Maria Moreno-Navarrete, Cecilia Aguilar-Plata, José Manuel Fernández-Real
BACKGROUND AND AIMS: Few studies have described the association between hepcidin levels and cardiometabolic risk in the general population and more so by considering robust adjustment for confounding factors. Therefore, the aim of the present study was to investigate the associations between circulating hepcidin and anthropometric, biochemical and vascular variables related to cardiometabolic risk in healthy individuals adjusting for relevant covariates. METHODS: Two-hundred thirty nine individuals (20-65 years old) were included in this cross-sectional study...
August 2015: Archives of Medical Research
Edgar Koyoc-Cardeña, Anuar Medina-Barreiro, Francisco Javier Escobedo-Ortegón, Jorge Carlos Rodríguez-Buenfil, Mario Barrera-Pérez, Enrique Reyes-Novelo, Juan Chablé-Santos, Celia Selem-Salas, Gonzalo Vazquez-Prokopec, Pablo Manrique-Saide
This study longitudinally investigated the association between Triatoma dimidiata infestation, triatomine infection with Trypanosoma cruzi and household/backyard environmental characteristics in 101 homesteads in Molas and Yucatan, Mexico, between November 2009 (rainy season) and May 2010 (dry season). Logistic regression models tested the associations between insect infestation/infection and potential household-level risk factors. A total of 200 T. dimidiata were collected from 35.6% of the homesteads, mostly (73%) from the peridomicile...
May 2015: Revista do Instituto de Medicina Tropical de São Paulo
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