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https://www.readbyqxmd.com/read/27630019/characterization-of-atg38-and-nrbf2-a-fifth-subunit-of-the-autophagic-vps34-pik3c3-complex
#1
Yohei Ohashi, Nicolas Soler, Miguel García Ortegón, Lufei Zhang, Marie L Kirsten, Olga Perisic, Glenn R Masson, John E Burke, Arjen J Jakobi, Apostolos A Apostolakis, Christopher M Johnson, Maki Ohashi, Nicholas T Ktistakis, Carsten Sachse, Roger L Williams
The phosphatidylinositol 3-kinase Vps34 is part of several protein complexes. The structural organization of heterotetrameric complexes is starting to emerge, but little is known about organization of additional accessory subunits that interact with these assemblies. Combining hydrogen-deuterium exchange mass spectrometry (HDX-MS), X-ray crystallography and electron microscopy (EM), we have characterized Atg38 and its human ortholog NRBF2, accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1-ATG14 (human)...
November 2016: Autophagy
https://www.readbyqxmd.com/read/27611771/patient-safety-incidents-and-adverse-events-in-ambulatory-dental-care-a-systematic-scoping-review
#2
Eduardo Ensaldo-Carrasco, Milton Fabian Suarez-Ortegon, Andrew Carson-Stevens, Kathrin Cresswell, Raman Bedi, Aziz Sheikh
BACKGROUND: There have been efforts to understand the epidemiology of iatrogenic harm in hospitals and primary care and to improve the safety of care provision. There has in contrast been very limited progress in relation to the safety of ambulatory dental care. OBJECTIVES: To provide a comprehensive overview of the range and frequencies of existing evidence on patient safety incidents and adverse events in ambulatory dentistry. METHODS: We searched MEDLINE and EMBASE for articles reporting events that could have or did result in unnecessary harm in ambulatory dental care...
September 8, 2016: Journal of Patient Safety
https://www.readbyqxmd.com/read/27605239/soluble-transferrin-receptor-levels-are-positively-associated-with-insulin-resistance-but-not-with-the-metabolic-syndrome-or-its-individual-components
#3
Milton Fabian Suárez-Ortegón, Stela McLachlan, Sarah H Wild, José Manuel Fernández-Real, Caroline Hayward, Ozren Polašek
The metabolic syndrome (MetS) is known to be associated with elevated serum ferritin levels. The possible association with other Fe markers has been less well studied. We aimed to investigate the cross-sectional association of soluble transferrin receptor (sTfR) and ferritin levels with the MetS components, insulin resistance and glycosylated Hb (HbA1C). The sample consisted of 725 adults, aged 19-93 years (284 men, 151 premenopausal and 290 postmenopausal women), from the Croatian island of Vis. Serum sTfR and ferritin levels were measured by immunoturbidimetry and electrochemiluminescence assays, respectively...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27088584/diagnosis-of-congenital-chagas-disease-using-an-iron-superoxide-dismutase-excreted-as-antigen-in-mothers-and-their-children-during-the-first-year-of-life
#4
Fanny Concha Valdez, Clotilde Marín, Javier Flores Abuxapqui, Javier Escobedo Ortegón, Rocío Cañas, Manuel Sánchez Moreno
BACKGROUND: Chagas disease caused by Trypanosoma cruzi is endemic in Latin America. Human infection is mainly spread by Triatominae insects. Other forms of transmission are congenital, blood transfusion and organ transplantation. METHODS: Anti-T. cruzi antibodies were determined by enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) in 155 serum samples from mothers and their babies. Indirect immunofluorescence (IFA) and a commercial test were used to validate efficacy of a specific ELISA-iron-excreted superoxide dismutase assay...
July 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27060865/influence-of-temperature-on-toxicity-of-single-pharmaceuticals-and-mixtures-in-the-crustacean-a-desmarestii
#5
Elena Nieto, Miriam Hampel, Enrique González-Ortegón, Pilar Drake, Julián Blasco
Lethal and sublethal responses of the shrimp Atyaephyra desmarestii exposed to three pharmaceutical compounds, Diclofenac (DF), Ibuprofen (IB) and Carbamazepine (CBZ), individually and in mixtures, were evaluated under two temperature scenarios. LC50 (96h) values were obtained individually at 20° and 25°C. At 25°C, mortality in binary and ternary mixtures is higher than at 20°C. The toxicity of the mixtures was predicted on the basis of individual mortality data using two toxicity models: Concentration addition (CA) and Independent action (IA)...
August 5, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27040367/assessing-the-importance-of-four-sandfly-species-diptera-psychodidae-as-vectors-of-leishmania-mexicana-in-campeche-mexico
#6
A Pech-May, G Peraza-Herrera, D A Moo-Llanes, J Escobedo-Ortegón, M Berzunza-Cruz, I Becker-Fauser, A C Montes DE Oca-Aguilar, E A Rebollar-Téllez
Localized cutaneous leishmaniasis represents a public health problem in many areas of Mexico, especially in the Yucatan Peninsula. An understanding of vector ecology and bionomics is of great importance in evaluations of the transmission dynamics of Leishmania parasites. A field study was conducted in the county of Calakmul, state of Campeche, during the period from November 2006 to March 2007. Phlebotomine sandfly vectors were sampled using Centers for Disease Control light traps, baited Disney traps and Shannon traps...
September 2016: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/26830308/prevalence-of-metabolic-syndrome-in-children-aged-5-9-years-from-southwest-colombia-a-cross-sectional-study
#7
Milton Fabian Suarez-Ortegón, Cecilia Aguilar-de Plata
BACKGROUND: Exploration of cardiometabolic alterations in the pre-adolescent stage is necessary to characterize possible patterns for matabolic syndrome (MetS) in the earliest stages of the life. However, defining specific cut-off points for metabolic and vascular markers represents a complex task in pre-adolescent populations. This study aimed to estimate the prevalence of MetS and its components in children aged 5-9 years old by using the MetS definition for adolescents with the lowest cut-off points, and evaluate its relationship with overweight and socio-demographic determinants...
February 1, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/26667697/-rebound-effect-of-intervention-programs-to-reduce-overweight-and-obesity-in-children-and-adolescents-systematic-review
#8
María José Aguilar Cordero, Alberto Ortegón Piñero, Laura Baena García, Jessica Pamela Noack Segovia, María Cristina Levet Hernández, Antonio Manuel Sánchez López
BACKGROUND: studies show that overweight and obesity are the result of a complex interaction between genetic and environmental factors that begins prenatally. In evidence of this relationship the potential impact of prenatal nutrition experience in the development of the endocrine and neuroendocrine systems that regulate energy balance, with special emphasis on leptin, an adipocytederived hormone. Different authors relate the risk of obesity with rapid weight gain in the first years of life...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/26664617/investigation-of-the-role-of-stereoelectronic-effects-in-the-conformation-of-piperidones-by-nmr-spectroscopy-and-x-ray-diffraction
#9
Cesar Garcias-Morales, David Ortegón-Reyna, Armando Ariza-Castolo
This paper reports the synthesis of a series of piperidones 1-8 by the Mannich reaction and analysis of their structures and conformations in solution by NMR and mass spectrometry. The six-membered rings in 2,4,6,8-tetraphenyl-3,7-diazabicyclo[3.3.1]nonan-9-ones, compounds 1 and 2, adopt a chair-boat conformation, while those in 2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9-ones, compounds 3-8, adopt a chair-chair conformation because of stereoelectronic effects. These stereoelectronic effects were analyzed by the (1) J C-H coupling constants, which were measured in the (13)C satellites of the (1)H NMR spectra obtained with the hetero-dqf pulse sequence...
2015: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/26394887/circulating-hepcidin-in-type-2-diabetes-a-multivariate-analysis-and-double-blind-evaluation-of-metformin-effects
#10
Milton Fabián Suárez-Ortegón, María Moreno, Alejandra Arbeláez, Gemma Xifra, Mildrey Mosquera, José María Moreno-Navarrete, Cecilia Aguilar-de Plata, Eduardo Esteve, Wifredo Ricart, José Manuel Fernández-Real
SCOPE: Very few studies have evaluated serum hepcidin in patients with type 2 diabetes and they have reported conflicting results. In addition, the effect of antidiabetic drugs on circulating hepcidin has not been explored so far. The aims of the study were to evaluate hepcidin concentrations and hepcidin/ferritin ratio in type 2 diabetes subjects and healthy non-diabetic controls and to evaluate the effect of metformin on hepcidin concentrations. METHODS AND RESULTS: Study 1: Cross-sectional multivariate study of 239 non-diabetic individuals and 65 people with type 2 diabetes...
December 2015: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/26372944/vinasse-application-to-sugar-cane-fields-effect-on-the-unsaturated-zone-and-groundwater-at-valle-del-cauca-colombia
#11
Gloria Páez Ortegón, Fernando Muñoz Arboleda, Lucila Candela, Karim Tamoh, Javier Valdes-Abellan
Extensive application of vinasse, a subproduct from sugar cane plantations for bioethanol production, is currently taking place as a source of nutrients that forms part of agricultural management in different agroclimatic regions. Liquid vinasse composition is characterised by high variability of organic compounds and major ions, acid pH (4.7), high TDS concentration (117,416-599,400mgL(-1)) and elevated EC (14,350-64,099μScm(-1)). A large-scale sugar cane field application is taking place in Valle del Cauca (Colombia), where monitoring of soil, unsaturated zone and the aquifer underneath has been made since 2006 to evaluate possible impacts on three experimental plots...
January 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/26279413/waist-height-ratio-waist-circumference-and-metabolic-syndrome-abnormalities-in-colombian-schooled-adolescents-a-multivariate-analysis-considering-located-adiposity
#12
Ricardo Antonio Agredo-Zúñiga, Cecilia Aguilar-de Plata, Milton Fabian Suárez-Ortegón
Very few large studies in Latin America have evaluated the association between waist:height ratio (W-HtR) and cardiometabolic risk in children and adolescents. Further, multivariable analyses verifying the independence of located subcutaneous fat have not been conducted so far. The aim of this study was to evaluate the associations of W-HtR and waist circumference (WC) with metabolic syndrome abnormalities and high LDL-cholesterol levels in schooled adolescents before and after adjusting for trunk skinfolds and BMI...
September 14, 2015: British Journal of Nutrition
https://www.readbyqxmd.com/read/26254700/circulating-hepcidin-is-independently-associated-with-systolic-blood-pressure-in-apparently-healthy-individuals
#13
Milton Fabian Suárez-Ortegón, Alejandra Arbeláez, Mildrey Mosquera, José Maria Moreno-Navarrete, Cecilia Aguilar-Plata, José Manuel Fernández-Real
BACKGROUND AND AIMS: Few studies have described the association between hepcidin levels and cardiometabolic risk in the general population and more so by considering robust adjustment for confounding factors. Therefore, the aim of the present study was to investigate the associations between circulating hepcidin and anthropometric, biochemical and vascular variables related to cardiometabolic risk in healthy individuals adjusting for relevant covariates. METHODS: Two-hundred thirty nine individuals (20-65 years old) were included in this cross-sectional study...
August 2015: Archives of Medical Research
https://www.readbyqxmd.com/read/26200970/chicken-coops-triatoma-dimidiata-infestation-and-its-infection-with-trypanosoma-cruzi-in-a-rural-village-of-yucatan-mexico
#14
Edgar Koyoc-Cardeña, Anuar Medina-Barreiro, Francisco Javier Escobedo-Ortegón, Jorge Carlos Rodríguez-Buenfil, Mario Barrera-Pérez, Enrique Reyes-Novelo, Juan Chablé-Santos, Celia Selem-Salas, Gonzalo Vazquez-Prokopec, Pablo Manrique-Saide
This study longitudinally investigated the association between Triatoma dimidiata infestation, triatomine infection with Trypanosoma cruzi and household/backyard environmental characteristics in 101 homesteads in Molas and Yucatan, Mexico, between November 2009 (rainy season) and May 2010 (dry season). Logistic regression models tested the associations between insect infestation/infection and potential household-level risk factors. A total of 200 T. dimidiata were collected from 35.6% of the homesteads, mostly (73%) from the peridomicile...
May 2015: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/26163379/individual-and-mixture-effects-of-selected-pharmaceuticals-on-larval-development-of-the-estuarine-shrimp-palaemon-longirostris
#15
Enrique González-Ortegón, Julian Blasco, Elena Nieto, Miriam Hampel, Lewis Le Vay, Luis Giménez
Few ecotoxicological studies incorporate within the experimental design environmental variability and mixture effects when assessing the impact of pollutants on organisms. We have studied the combined effects of selected pharmaceutical compounds and environmental variability in terms of salinity and temperature on survival, development and body mass of larvae of the estuarine shrimp Palaemon longirostris. Drug residues found in coastal waters occur as mixture, and the evaluation of combined effects of simultaneously occurring compounds is indispensable for their environmental risk assessment...
January 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/26118862/a-salt-bath-will-keep-you-going-euryhalinity-tests-and-genetic-structure-of-caridean-shrimps-from-iberian-rivers
#16
Enrique González-Ortegón, Ferran Palero, Christophe Lejeusne, Pilar Drake, Jose A Cuesta
We assessed the role of euryhalinity and life-history traits on the population genetic structure of the four main caridean shrimp species from the Iberian Peninsula (Atyaephyra desmarestii, Dugastella valentina, Palaemon varians and Palaemon zariquieyi) able to complete their life cycle in freshwater/oligohaline habitats. Seawater exposure experiments indicated that A. desmarestii, D. valentina and P. zariquieyi are more sensitive to high salinity waters than P. varians and confirm the relationship between osmolality regulation and spatial distribution of species...
January 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/25973143/comparison-of-metabolic-pathways-in-escherichia-coli-by-using-genetic-algorithms
#17
Patricia Ortegon, Augusto C Poot-Hernández, Ernesto Perez-Rueda, Katya Rodriguez-Vazquez
In order to understand how cellular metabolism has taken its modern form, the conservation and variations between metabolic pathways were evaluated by using a genetic algorithm (GA). The GA approach considered information on the complete metabolism of the bacterium Escherichia coli K-12, as deposited in the KEGG database, and the enzymes belonging to a particular pathway were transformed into enzymatic step sequences by using the breadth-first search algorithm. These sequences represent contiguous enzymes linked to each other, based on their catalytic activities as they are encoded in the Enzyme Commission numbers...
2015: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/25945813/relationship-between-maternal-and-newborn-endothelial-function-and-oxidative-stress
#18
Isabella Echeverri, José Guillermo Ortega-Ávila, Mildrey Mosquera, Andrés Castillo, Eliécer Jiménez, Milton Fabian Suárez-Ortegon, Julio Cesar Mateus, Cecilia Aguilar-de Plata
OBJECTIVE: To evaluate the Relationship between maternal and newborn endothelial function and oxidative stress. METHODS: Forty-three pregnant women and their offspring were evaluated. As markers of endothelial function, the flow-mediated dilation (FMD) was measured in pregnant women in the second and third trimesters, and nitric oxide (NO) was quantified in the endothelial cells of the umbilical cord vein. Malondialdehyde (MDA), as a marker of oxidative stress, was measured in the maternal plasma (second and third trimesters) and plasma from umbilical cord blood...
November 2015: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/25609727/improving-leishmania-species-identification-in-different-types-of-samples-from-cutaneous-lesions
#19
Mónica L Cruz-Barrera, Clemencia Ovalle-Bracho, Viviana Ortegon-Vergara, Jairo E Pérez-Franco, Maria C Echeverry
The discrimination of Leishmania species from patient samples has epidemiological and clinical relevance. In this study, different gene target PCR-restriction fragment length polymorphism (RFLP) protocols were evaluated for their robustness as Leishmania species discriminators in 61 patients with cutaneous leishmaniasis. We modified the hsp70-PCR-RFLP protocol and found it to be the most reliable protocol for species identification.
April 2015: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/25554549/nasal-colonization-and-lower-respiratory-tract-infections-with-methicillin-resistant-staphylococcus-aureus
#20
Belen Tilahun, Andrew C Faust, Phyllis McCorstin, Anthony Ortegon
BACKGROUND: Methicillin-resistant Staphylococcus aureus is a cause of lower respiratory tract infections, particularly health care- and ventilator-associated pneumonia. Although many health systems use nasal screening for this microorganism for infection control, correlation between nasal carriage of the organism and development of infections due to it is not clear. METHODS: Records of patients admitted to medical intensive care between January 1, 2011, and December 31, 2012, were reviewed retrospectively...
January 2015: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
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