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https://www.readbyqxmd.com/read/29457916/systematic-review-of-psychiatric-signs-in-niemann-pick-disease-type-c
#1
Olivier Bonnot, Hans-Hermann Klünemann, Christian Velten, Juan Vicente Torres Martin, Mark Walterfang
OBJECTIVES: We conducted the first systematic literature review and analysis of psychiatric manifestations in Niemann-Pick disease type C (NPC) to describe: 1) time of occurrence of psychiatric manifestations relative to other disease manifestations; 2) frequent combinations of psychiatric, neurological and visceral disease manifestations. METHODS: A systematic EMBase literature search was conducted to identify, collate and analyze published data from patients with NPC associated with psychiatric symptoms, published between January 1967 and November 2015...
February 19, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29447884/knowledge-and-attitudes-of-early-childhood-development-practitioners-towards-hearing-health-in-poor-communities
#2
Shouneez Yousuf Hussein, De Wet Swanepoel, Leigh Biagio de Jager, Faheema Mahomed-Asmail
OBJECTIVE: Within the educational sector of low-and middle-income countries (LMICs), formal and informal early childhood development (ECD) centers are often the first point of contact for majority of children. Since early hearing detection services are mostly absent in LMICs, these ECD centers may serve as the first point of access to screenings for these children. ECD practitioner awareness regarding hearing and hearing loss is essential for the successful implementation of hearing screening programs...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447880/analysis-of-risk-factors-associated-with-unilateral-hearing-loss-in-children-who-initially-passed-newborn-hearing-screening
#3
Eric N Appelbaum, Jessica B Howell, Derek Chapman, Arti Pandya, Kelley M Dodson
OBJECTIVE: To analyze 2007 Joint Committee on Infant Hearing (JCIH) risk factors in children with confirmed unilateral hearing loss (UHL) who initially passed newborn hearing screening. METHODS: Retrospective record review of 16,108 infants who passed newborn hearing screening but had one or more JCIH risk factors prompting subsequent follow-up through the universal newborn hearing screening (UNHS) program in Virginia from 2010 to 2012. The study was reviewed and qualified as exempt by the Virginia Commonwealth University Institutional Review Board (IRB) and the Virginia Department of Health...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447821/genetic-analysis-of-cldn14-in-the-chinese-population-affected-with-non-syndromic-hearing-loss
#4
Yajie Lu, Jun Yao, Qinjun Wei, Jin Xu, Guangqian Xing, Xin Cao
OBJECTIVE: The CLDN14 gene, encoding the tight junction protein Claudin-14, has been proposed as a candidate causative gene affecting autosomal recessive non-syndromic hearing loss (ARNSHL). Genetic analysis of nonsynonymous single-nucleotide variations (nsSNVs) in CLDN14 has been performed in different populations. The role of CLDN14 nsSNVs in contributing to hearing loss in Chinese populations would be investigated in this study. METHODS: Target screening for CLDN14 variations were conducted in 500 unrelated patients diagnosed with non-syndromic hearing loss (NSHL)...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447811/sensorineural-and-conductive-hearing-loss-in-infants-diagnosed-in-the-program-of-universal-newborn-hearing-screening
#5
Katarzyna Wroblewska-Seniuk, Piotr Dabrowski, Grazyna Greczka, Katarzyna Szabatowska, Agata Glowacka, Witold Szyfter, Jan Mazela
OBJECTIVE: The aim of this study was to analyze infants diagnosed with sensorineural or conductive hearing deficit and to identify risk factors associated with these defects. MATERIAL AND METHODS: A retrospective analysis of infants diagnosed with hearing deficit based on the database of the universal newborn hearing screening program and medical records of the patients. RESULTS: 27 935 infants were covered by the universal neonatal hearing screening program...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447805/characterization-of-newborn-hearing-screening-failures-in-multigestational-births
#6
Jonathan Ross Mallen, Jacob B Hunter, Charles Auerbach, Leslie Wexler, Andrea Vambutas
OBJECTIVE: To define the rate and characterize the type of newborn hearing screening failures in multigestational births. METHODS: Retrospective chart review of all multigestational births that occurred in a 10-year period (2002-2012) in which at least one newborn failed newborn hearing screening at two tertiary care hospitals in the Northwell Health System. RESULTS: Out of 125,405 total births, we identified 2961 multigestational births, of which 59 (2...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447803/maternal-knowledge-and-attitudes-to-universal-newborn-hearing-screening-reviewing-an-established-program
#7
Maggie Yee Yan Lam, Eddie Chi Ming Wong, Chi Wai Law, Helena Hui Ling Lee, Bradley McPherson
OBJECTIVES: To facilitate early diagnosis of infants with hearing loss, a universal newborn hearing screening program (UNHS) has been implemented in Hong Kong's public hospitals for over a decade. However, there have been no known studies investigating parent attitudes to, and satisfaction with, UNHS since its launch in Hong Kong. The present study aimed to investigate knowledge of UNHS as well as infant hearing development, and attitudes and satisfaction with UNHS, in Hong Kong mothers with newborns...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447253/combined-impairments-in-vision-hearing-and-cognition-are-associated-with-greater-levels-of-functional-and-communication-difficulties-than-cognitive-impairment-alone-analysis-of-interrai-data-for-home-care-and-long-term-care-recipients-in-ontario
#8
Dawn M Guthrie, Jacob G S Davidson, Nicole Williams, Jennifer Campos, Kathleen Hunter, Paul Mick, Joseph B Orange, M Kathleen Pichora-Fuller, Natalie A Phillips, Marie Y Savundranayagam, Walter Wittich
OBJECTIVES: The objective of the current study was to understand the added effects of having a sensory impairment (vision and/or hearing impairment) in combination with cognitive impairment with respect to health-related outcomes among older adults (65+ years old) receiving home care or residing in a long-term care (LTC) facility in Ontario, Canada. METHODS: Cross-sectional analyses were conducted using existing data collected with one of two interRAI assessments, one for home care (n = 291,824) and one for LTC (n = 110,578)...
2018: PloS One
https://www.readbyqxmd.com/read/29441835/current-profile-of-adults-presenting-for-preoperative-cochlear-implant-evaluation
#9
Jourdan T Holder, Susan M Reynolds, Linsey W Sunderhaus, René H Gifford
Considerable advancements in cochlear implant technology (e.g., electric acoustic stimulation) and assessment materials have yielded expanded criteria. Despite this, it is unclear whether individuals with better audiometric thresholds and speech understanding are being referred for cochlear implant workup and pursuing cochlear implantation. The purpose of this study was to characterize the mean auditory and demographic profile of adults presenting for preoperative cochlear implant workup. Data were collected prospectively for all adult preoperative workups at Vanderbilt from 2013 to 2015...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/29433858/hearing-loss-in-type-2-diabetes-in-association-with-diabetic-neuropathy
#10
Huihui Ren, Zhenggang Wang, Zhongyao Mao, Ping Zhang, Chunfang Wang, Aiguo Liu, Gang Yuan
BACKGROUND: Reports assessing hearing abnormalities in diabetes are debated. We aimed to evaluated auditory alterations and their possible associations with vascular and neurological dysfunction in 160 Type 2 diabetes mellitus individuals and 100 age and sex-matched healthy controls. METHODS: Participants underwent pure tone audiometry (PTA). Associations with demographic, metabolic and neuropathic variables were assessed. RESULTS: Compared with healthy controls, diabetic patients had higher mean hearing thresholds at each frequency, with statistical significance at 2-8 kHz (p <0...
February 9, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29428705/risk-factors-for-failure-in-the-newborn-hearing-screen-test-in-very-preterm-twins
#11
So Young Kim, Byung Yoon Choi, Eun Young Jung, Hyunsoo Park, Ha-Na Yoo, Kyo Hoon Park
BACKGROUND: We aimed to identify prenatal and postnatal risk factors associated with abnormal newborn hearing screen (NHS) results and subsequently confirmed sensorineural hearing loss (SNHL) in preterm twin neonates. METHODS: Electronic medical records of 159 twin neonates who were born alive after ≤32 weeks were retrospectively reviewed for hearing loss in both ears. Histopathologic examination of the placenta was performed and clinical data, including method of conception and factors specific to twins, were retrieved from a computerized perinatal database...
January 31, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29427586/inhibition-of-human-tyrosinase-requires-molecular-motifs-distinctively-different-from-mushroom-tyrosinase
#12
Tobias Mann, Wolfram Gerwat, Jan Batzer, Kerstin Eggers, Cathrin Scherner, Horst Wenck, Franz Stäb, Vincent J Hearing, Klaus-Heinrich Röhm, Ludger Kolbe
Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most prominent target to inhibit hyperpigmentation. Numerous tyrosinase inhibitors have been identified, but most of those lack clinical efficacy because they were identified using mushroom tyrosinase as the target. Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-known whitening ingredients. Hydroquinone and its derivative arbutin only weakly inhibited human tyrosinase with a half-maximal inhibitory concentration (IC50) in the millimolar range, while kojic acid showed a weak efficacy (IC50 > 400 μM)...
February 7, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29427525/frailty-versus-stopping-elderly-accidents-deaths-and-injuries-initiative-fall-risk-score-ability-to-predict-future-falls
#13
Rebecca S Crow, Matthew C Lohman, Dawna Pidgeon, Martha L Bruce, Stephen J Bartels, John A Batsis
OBJECTIVES: To compare the ability of frailty status to predict fall risk with that of community fall risk screening tools. DESIGN: Analysis of cross-sectional and longitudinal data from NHATS. SETTING: National Health and Aging Trend Study (NHATS) 2011-2015. PARTICIPANTS: Individuals aged 65 and older (N = 7,392). MEASUREMENTS: Fall risk was defined according to the Stopping Elderly Accidents, Deaths and Injuries (STEADI) initiative...
February 10, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29427298/meningitis-as-a-consequence-of-otitis-media-in-a-child-referred-from-the-newborn-hearing-screening-programme-a-missed-opportunity
#14
Lorenza Matarazzo, Silvia Nider, Saba Battelino, Enrico Muzzi, Eva Orzan, Alessandro Ventura, Egidio Barbi
No abstract text is available yet for this article.
February 10, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29425343/prevalence-and-causes-of-musculoskeletal-impairment-in-mahabubnagar-district-telangana-state-india-results-of-a-population-based-survey
#15
Tracey Smythe, Islay Mactaggart, Hannah Kuper, G V S Murthy, Christopher Lavy, Sarah Polack
Background: Musculoskeletal impairments (MSI) are the leading contributor to global years lived with disability. Comparable epidemiological data on MSI is lacking, and are needed to inform health and rehabilitative services. This study aimed to estimate the prevalence and causes of MSI in Telangana State, India. Method: A population-based survey used probability proportionate to size and compact-segment sampling to select 51 clusters of 80 individuals (all ages)...
February 7, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29417278/validation-of-the-second-version-of-the-littlears%C3%A2-early-speech-production-questionnaire-leespq-in-german-speaking-children-with-normal-hearing
#16
Annerose Keilmann, Barbara Friese, Anne Lässig, Vanessa Hoffmann
INTRODUCTION: The introduction of neonatal hearing screening and the increasingly early age at which children can receive a cochlear implant has intensified the need for a validated questionnaire to assess the speech production of children aged 0‒18. Such a questionnaire has been created, the LittlEARS® Early Speech Production Questionnaire (LEESPQ). This study aimed to validate a second, revised edition of the LEESPQ. METHODS AND MATERIALS: Questionnaires were returned for 362 children with normal hearing...
February 7, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29408584/novel-mitochondrial-gene-variants-in-northwestern-chinese-probands-with-non-syndromic-hearing-loss-by-whole-mitochondrial-genome-screening
#17
Xiaowan Chen, Fang Wang, Aishanjiang Maerhaba, Qianqian Li, Jianchao Wang, Xiaowen Liu, Jing Zheng, Ye Chen, YuFen Guo
Mitochondrial DNA mutations play an important role in hereditary hearing loss. The present study aimed at identifying more novel genetic variants of mitochondrial DNA. Complete Mitochondrial genomes were detected in 97 Northwestern Chinese probands with non-syndromic hearing loss and 376 control subjects. The variants were evaluated for the pathogenicity using the following criteria: (1) present in <1% of the controls, (2) evolutional conservation, (3) potential structural and functional alterations. Mutational analysis in probands identified 706 variants, including 180 variants in the D loop region, 27 variants in the 12S rRNA gene, 29 variants in the 16S rRNA gene, 122 missense variants and 312 silent variants in the protein coding gene, 29 variants in the tRNA genes and 7 variants in the non-coding region...
January 30, 2018: Gene
https://www.readbyqxmd.com/read/29401060/exponential-modeling-of-frequency-following-responses-in-american-neonates-and-adults
#18
Fuh-Cherng Jeng, Brandie Nance, Karen Montgomery-Reagan, Chia-Der Lin
BACKGROUND: The scalp-recorded frequency-following response (FFR) has been widely accepted in assessing the brain's processing of speech stimuli for people who speak tonal and nontonal languages. Characteristics of scalp-recorded FFRs with increasing number of sweeps have been delineated through the use of an exponential curve-fitting model in Chinese adults; however, characteristics of speech processing for people who speak a nontonal language remain unclear. PURPOSE: This study had two specific aims...
February 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29401058/predictive-accuracy-of-sweep-frequency-impedance-technology-in-identifying-conductive-conditions-in-newborns
#19
Venkatesh Aithal, Joseph Kei, Carlie Driscoll, Michio Murakoshi, Hiroshi Wada
BACKGROUND: Diagnosing conductive conditions in newborns is challenging for both audiologists and otolaryngologists. Although high-frequency tympanometry (HFT), acoustic stapedial reflex tests, and wideband absorbance measures are useful diagnostic tools, there is performance measure variability in their detection of middle ear conditions. Additional diagnostic sensitivity and specificity measures gained through new technology such as sweep frequency impedance (SFI) measures may assist in the diagnosis of middle ear dysfunction in newborns...
February 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29394108/participant-outcomes-from-methods-of-recruitment-for-videogame-research
#20
Courtney Ryan, Hafza Dadabhoy, Tom Baranowski
OBJECTIVE: The most productive methods of recruitment for a videogame for health (G4H) trial are not known. Success or failure of recruitment methods has been reported for a variety of clinical trials, but few specifically for G4H trials. This study's goal was to recruit 444 overweight or obese (body mass index percentile between the 84.5th-99.4th percentiles) children between the ages of 10-12 years. The article reports the results of different methods of participant recruitment. MATERIALS AND METHODS: Participants had to agree to three fasting blood samples (baseline, immediately after, and 2 months later); be willing to wear an accelerometer for 7 days at each assessment; read and speak English fluently (because the games were in English); have no history of any condition that would affect what he/she could eat or how much physical activity he/she could get; and have an eligible home computer purchased in the last 5 years with high-speed internet...
February 2018: Games for Health
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