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https://www.readbyqxmd.com/read/29772406/fertility-pregnancy-and-clinical-outcomes-after-uterine-arteriovenous-malformation-management
#1
Sophie Delplanque, Maela Le Lous, Maïa Proisy, Yolaine Joueidi, Estelle Bauville, Celine Rozel, Eugénie Beraud, Bertrand Bruneau, Jean Levêque, Vincent Lavoué, Krystel Nyangoh Timoh
STUDY OBJECTIVE: To evaluate fertility, pregnancy, and clinical outcomes after uterine arteriovenous malformation (UAVM) management. DESIGN: Single-center retrospective study from January 2000 to July 2017. (Canadian task force III). SETTING: One referral center. PATIENTS: Twenty-two patients with a UAVM diagnosed by Magnetic Resonance Angiography (MRA) or Computed Tomography (CT) angiography and managed by Expectant Management (EM) or Uterine Arterial Embolization (UAE) during the study period were included...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29765296/peripartum-haemorrhage-haemostatic-aspects-of-the-new-german-pph-guideline
#2
REVIEW
Heiko Lier, Christian von Heymann, Wolfgang Korte, Dietmar Schlembach
Summary Peripartum haemorrhage remains one of the main causes of maternal mortality world-wide. The German, Austrian and Swiss Societies of Gynaecology and Obstetrics have updated the current guidelines for the treatment of peripartum haemorrhage together with the German Society of Anaesthesiology and Intensive Care Medicine and the Society of Thrombosis and Haemostasis Research. The recommendations have been the result of a thorough review of the available scientific literature and a consensus process involving all members of the guideline group...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29758989/the-double-hazard-of-bleeding-and-thrombosis-in-hemostasis-from-a-clinical-point-of-view-a-global-assessment-by-rotational-thromboelastometry-rotem
#3
Olga Meltem Akay
Hemostasis is a complex dynamic process involving bleeding and thrombosis as two end-points. Conventional coagulation tests which are measured in plasma examine only isolated portions of the coagulation cascade, thereby giving no information on important interactions essential to the clinical evaluation of hemostatic function. Thromboelastography (TEG), originally described in 1948 has improved over the decades and become a valuable tool of coagulation testing because of the limitations of standard coagulation tests...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29757132/safety-and-efficacy-of-tranexamic-acid-for-prevention-of-obstetric-haemorrhage-an-updated-systematic-review-and-meta-analysis
#4
REVIEW
Massimo Franchini, Carlo Mengoli, Mario Cruciani, Valentino Bergamini, Francesca Presti, Giuseppe Marano, Simonetta Pupella, Stefania Vaglio, Francesca Masiello, Eva Veropalumbo, Vanessa Piccinini, Ilaria Pati, Giancarlo M Liumbruno
BACKGROUND: A number of clinical systematic review and meta-analysis have been published on the use of tranexamic in the obstetric setting. The aim of this meta-analysis was to evaluate the safety and effectiveness of tranexamic acid in reducing blood loss when given prior to caesarean delivery. MATERIALS AND METHODS: We searched the Cochrane Wounds Specialized Register, Cochrane Central, MEDLINE (through PUBMED), Embase, and SCOPUS electronic databases. We also searched clinical trials registries for ongoing and unpublished studies, and checked reference lists to identify additional studies...
April 3, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29751813/ruptured-caesarean-scar-ectopic-pregnancy-a-diagnostic-dilemma-in-a-resource-limited-setting
#5
Atem Bethel Ajong, Bruno Kenfack, Valirie Ndip Agbor, Philip Nana Njotang
BACKGROUND: Caesarean scar pregnancy (CSP) remains a very rare form of ectopic pregnancy associated with serious life threatening obstetric complications and even death in case of late diagnosis and treatment. CASE PRESENTATION: We report a case of a ruptured caesarean scar pregnancy in a 29 year-old gravida 5, para 3 with a past obstetric history of two consecutive caesarean sections done 9 and 5 years ago respectively. The patient presented with intermittent lower abdominal pains on a 20 weeks gestation associated with mild epigastralgia and 2 previous episodes of mild pervaginal bleeding (2 and 1 months ago respectively before consultation) managed with injectable progesterone...
May 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29746814/a-case-series-on-the-use-of-levonorgestrel-52mg-intrauterine-system-after-organ-transplant
#6
Cassia R T Juliato, Paulo Stahlscmidt, Arlete Fernandes, Ilza Monteiro, Luis Bahamondes
OBJECTIVE: To assess the clinical performance (pregnancy and occurrence of pelvic infection) of the levonorgestrel 52-mg intrauterine system (LNG IUS) in solid organ transplant recipients. STUDY DESIGN: We performed a retrospective chart review of all patients seen in the Family Planning Clinic at the University of Campinas Department of Obstetrics and Gynecology from 2007-2017 to identify women with solid organ transplantation using immunosuppression who received a LNG- IUS...
May 7, 2018: Contraception
https://www.readbyqxmd.com/read/29729522/relaparotomy-following-cesarean-section-a-single-center-study
#7
Hubert Huras, Malgorzata Radon-Pokracka, Magdalena Nowak
INTRODUCTION: Relaparotomy is a serious complication of caesarean section. The aim of this study was to investigate its risk factors and postoperative outcome. METHODS: We conducted a retrospective case-control study examining 48 reoperations between January 2013 and June 2017 at the Obstetrics and Perinatology Department, Jagiellonian University Hospital in Cracow, Poland. This is tertiary referral center, in that time 8421 cesarean section were performed. The control group was randomly matched from all CS in a 1 to 2 ratio...
April 26, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29727248/quantitative-fetal-fibronectin-and-cervical-length-in-symptomatic-women-results-from-a-prospective-blinded-cohort-study
#8
Lisa D Levine, Katheryne L Downes, Julie A Romero, Hope Pappas, Michal A Elovitz
OBJECTIVES: Our objectives were to determine whether quantitative fetal fibronectin (fFN) and cervical length (CL) screening can be used alone or in combination as prognostic tests to identify symptomatic women at highest or lowest risk for spontaneous preterm birth (sPTB). METHODS: A prospective, blinded cohort study of women presenting with a singleton gestation to our triage unit between 22-33w6d with preterm labor symptoms was performed. Women with ruptured membranes, moderate/severe bleeding, and dilation > 2 cm were excluded...
May 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29720744/peripartum-haemorrhage-diagnosis-and-therapy-guideline-of-the-dggg-oeggg-and-sggg-s2k-level-awmf-registry-no-015-063-march-2016
#9
Dietmar Schlembach, Hanns Helmer, Wolfgang Henrich, Christian von Heymann, Franz Kainer, Wolfgang Korte, Maritta Kühnert, Heiko Lier, Holger Maul, Werner Rath, Susanne Steppat, Daniel Surbek, Jürgen Wacker
Purpose: This is an official interdisciplinary guideline, published and coordinated by the German Society of Gynaecology and Obstetrics (DGGG), the Austrian Society of Gynaecology and Obstetrics (OEGGG) and the Swiss Society of Gynaecology and Obstetrics (SGGG). The guideline was developed for use in German-speaking countries and is backed by the German Society of Anaesthesiology and Intensive Medicine (DGAI), the Society of Thrombosis and Haemostasis Research (GTH) and the German Association of Midwives...
April 2018: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29668367/which-patients-with-cervical-squamous-cell-carcinoma-might-benefit-from-neoadjuvant-chemotherapy
#10
Omar Mahmoud, Mark H Einstein
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
April 18, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29661217/barriers-to-access-and-utilization-of-emergency-obstetric-care-at-health-facilities-in-sub-saharan-africa-a-systematic-review-protocol
#11
Ayele Geleto, Catherine Chojenta, Abdulbasit Mussa, Deborah Loxton
BACKGROUND: Nearly 15% of all pregnancies end in fatal perinatal obstetric complications including bleeding, infections, hypertension, obstructed labor, and complications of abortion. Between 1990 and 2015, an estimated 10.7 million women died due to obstetric complications. Almost all of these deaths (99%) happened in developing countries, and 66% of maternal deaths were attributed to sub-Saharan Africa. The majority of cases of maternal mortalities can be prevented through provision of evidence-based potentially life-saving signal functions of emergency obstetric care...
April 16, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29660502/the-place-of-fibrinogen-concentrates-in-the-management-of-perioperative-bleeding-a-position-paper-from-the-francophone-working-group-on-perioperative-hemostasis-gihp
#12
REVIEW
Charles Marc Samama, Brigitte Ickx, Yves Ozier, Annick Steib, Sophie Susen, Anne Godier
The consumption of fibrinogen concentrates has been increasing steadily for several years in surgery, trauma and obstetrics. However, data from the literature are conflicting. The French Working Group on Perioperative Haemostasis (GIHP) proposes a position paper based on a narrative review of the literature, and addresses the following questions: - What is the exact role of fibrinogen in haemostasis? - Which rational support for the use of perioperative fibrinogen? - Which thrombotic risk? - What are the most recent professional recommendations on the use of fibrinogen concentrates? Then, evidence-based recommendations are proposed: 1 - It is suggested not to administer prophylactic FC to prevent haemorrhage...
April 13, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29652744/clinical-pearls-part-3-anaesthetic-management-of-abnormally-invasive-placentation
#13
Vinod Patil, Gamunu Ratnayake, Galina Fastovets, D S Wijayatilake
PURPOSE OF REVIEW: Abnormal placentation is a clinical condition seen increasingly in the pregnant population. It is associated with significant morbidity and mortality, which may be mitigated through robust multidisciplinary care for these patients. The role of maternal critical care for these patients has largely been ignored in the literature. RECENT FINDINGS: Advances in pharmacological management of bleeding with recent publications of large multicentre trials in addition to new technologies in the management of massive obstetric haemorrhage (MOH) have revolutionized the management of abnormal placentation...
June 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29630130/inhibitive-effects-of-microrna-34a-on-protecting-against-ischemia-reperfusion-injury-of-vital-organs-in-hemorrhagic-shock-pregnant-mice
#14
L-B Qin, Z-Y Li, H Li, X-Q Fan, H-G Liu, X-M Dong, W-Y Jia
OBJECTIVE: Hemorrhagic shock is a common vital condition in obstetrics, and major treatment consists of bleeding control and liquid resuscitation. MicroRNA (miR) has been found to regulate multiple diseases. However, its expression profile in hemorrhagic shock or effects on the ischemia-reperfusion injury in pregnant mice has not been reported yet. PATIENTS AND METHODS: This study generated rat hemorrhagic shock pregnant model, on which real-time quantitative PCR was used to measure miR-34a expressions...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29594003/snake-bite-in-third-trimester-of-pregnancy-with-systemic-envenomation-and-delivery-of-a-live-baby-in-a-low-resource-setting-a-case-report
#15
Adebayo A Adewole, Osadolor A Ugiagbe, Temitope G Onile, Gabriel A Joseph, Oluwamayowa D Kassim, Patricia F Medupin, Abiodun S Adeniran
Background: Snake bite in the third trimester of pregnancy with late presentation, systemic envenomation; disseminated intravascular coagulopathy and delivery of a live neonate is uncommon in a low resource setting. Case: We present a 22 year old unbooked Gravida 3 Para 1+ 1 1alive lentiviral positive woman at 32 weeks gestation with snake bite, leg swelling, vaginal bleeding and labour pains. At presentation, there were anemia, tachycardia, hypotension; a gravid uterus with a single fetus in longitudinal lie, cephalic presentation, regular fetal heart rate and cervical dilatation of 3 cm...
October 2017: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29584463/do-we-still-need-cryoprecipitate-cryoprecipitate-and-fibrinogen-concentrate-as-treatments-for-major-hemorrhage-how-do-they-compare
#16
Alex Novak, Simon J Stanworth, Nicola Curry
Major hemorrhage is a source of significant mortality and morbidity worldwide. Identification and characterization of coagulation impairment associated with major hemorrhage has suggested a key role for fibrinogen deficiency, however the optimum mode of replacement of fibrinogen remains unclear, and standardized major hemorrhage protocols may overlook context-dependent variations in individual patients' clotting derangement. Areas covered: This paper examines the current practice and evidence regarding the role of different modes of fibrinogen replacement in major hemorrhage in 3 distinct clinical settings: trauma, obstetric hemorrhage, and gastrointestinal hemorrhage with associated liver disease...
May 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29549777/an-opinion-on-the-benefits-of-concomitant-oral-contraceptive-therapy-in-premenopausal-women-treated-with-oral-anticoagulants
#17
REVIEW
Richard Godin, Geneviève Roy, James Douketis
Women who are receiving an oral anticoagulant appear to be at higher risk of developing bleeding-related adverse events than men. Physiological bleeding related to the ovulatory cycle poses an ongoing risk for bleeding complications during anticoagulant therapy. Abnormal uterine bleeding and hemorrhagic ovarian cysts are risks specific to women of reproductive age who are treated with anticoagulants. The use of combined oral contraceptives can help minimize such adverse events and would also mitigate the risks of obstetrical complications related to thrombosis and anticoagulation, in addition to avoiding fetal exposure to potentially teratogenic anticoagulants...
March 8, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29540895/emergency-peripartum-hysterectomy-a-retrospective-study-in-a-tertiary-care-hospital-in-turkey-from-2007-to-2015
#18
Dilek Uysal, Hakan Cokmez, Cetin Aydin, Tolga Ciftpinar
Postpartum haemorrhage is the most important cause of maternal morbidity and mortality, especially when all conservative measures, including syntometrine oxytocin and Bakri balloons have failed to accomplish haemostasis and expeditious surgical procedures, such as uterine artery ligation and emergency peripartum hysterectomy (EPH) are required. This retrospective study analysed 31 cases of EPH performed between January 2007 and January 2016 in the Department of Gynecology and Obstetrics of Izmir Ataturk Teaching and Research Hospital...
March 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29529476/characterization-of-the-population-with-severe-iron-deficiency-anemia-at-risk-of-requiring-intravenous-iron-supplementation
#19
Josep Estadella, Laura Villamarín, Anna Feliu, Josep Perelló, Joaquim Calaf
Iron deficiency anemia is the most frequent cause of anemia world-wide and is a very common disorder in daily medical practice. Heavy menstrual bleeding (menorrhagia) and pregnancy and delivery can cause significant iron loss leading to severe anemia The aim of the present study was to characterize the population requiring intravenous iron and identify whether gynecological and obstetric iron loss are frequent indications for treatment. MATERIAL AND METHODS: Restrospective, single center study performed in a tertiary level university hospital from January 2014 to December 2016...
May 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29519377/a-multidisciplinary-approach-on-the-perioperative-antithrombotic-management-of-patients-with-coronary-stents-undergoing-surgery-surgery-after-stenting-2
#20
REVIEW
Roberta Rossini, Giuseppe Tarantini, Giuseppe Musumeci, Giulia Masiero, Emanuele Barbato, Paolo Calabrò, Davide Capodanno, Sergio Leonardi, Maddalena Lettino, Ugo Limbruno, Alberto Menozzi, U O Alfredo Marchese, Francesco Saia, Marco Valgimigli, Walter Ageno, Anna Falanga, Antonio Corcione, Alessandro Locatelli, Marco Montorsi, Diego Piazza, Andrea Stella, Antonio Bozzani, Alessandro Parolari, Roberto Carone, Dominick J Angiolillo
Perioperative management of antithrombotic therapy in patients treated with coronary stents undergoing surgery remains poorly defined. Importantly, surgery represents a common reason for premature treatment discontinuation, which is associated with an increased risk in mortality and major adverse cardiac events. However, maintaining antithrombotic therapy to minimize the incidence of perioperative ischemic complications may increase the risk of bleeding complications. Although guidelines provide some recommendations with respect to the perioperative management of antithrombotic therapy, these have been largely developed according to the thrombotic risk of the patient and a definition of the hemorrhagic risk specific to each surgical procedure, key to defining the trade-off between ischemia and bleeding, is not provided...
March 12, 2018: JACC. Cardiovascular Interventions
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