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https://www.readbyqxmd.com/read/29352442/laparoscopic-and-endoscopic-cooperative-surgery-versus-endoscopic-submucosal-dissection-for-the-treatment-of-low-risk-tumors-of-the-duodenum
#1
Toshiyasu Ojima, Mikihito Nakamori, Masaki Nakamura, Keiji Hayata, Masahiro Katsuda, Katsunari Takifuji, Hiroki Yamaue
BACKGROUND: There have been no comparative studies of endoscopic submucosal dissection (ESD) and laparoscopic and endoscopic cooperative surgery (LECS) for patients with duodenal tumors regarding surgical outcomes. The aim of this study is to compare the safety and feasibility of short-term surgical outcomes of ESD and LECS for patients with low-risk tumors of the duodenum. METHODS: This was a single-center retrospective study of 68 consecutive patients with low-risk tumors of the duodenum who received surgical treatments...
January 19, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29352355/physiological-responses-to-salt-stress-of-salt-adapted-and-directly-salt-nacl-and-nacl-na2so4-mixture-stressed-cyanobacterium-anabaena-fertilissima
#2
Prashant Swapnil, Ashwani K Rai
Soil salinity in nature is generally mixed type; however, most of the studies on salt toxicity are performed with NaCl and little is known about sulfur type of salinity (Na2SO4). Present study discerns the physiologic mechanisms responsible for salt tolerance in salt-adapted Anabaena fertilissima, and responses of directly stressed parent cells to NaCl and NaCl+Na2SO4 mixture. NaCl at 500 mM was lethal to the cyanobacterium, whereas salt-adapted cells grew luxuriantly. Salinity impaired gross photosynthesis, electron transport activities, and respiration in parent cells, but not in the salt-adapted cells, except a marginal increase in PSI activity...
January 19, 2018: Protoplasma
https://www.readbyqxmd.com/read/29352191/oral-administration-of-proteus-mirabilis-damages-dopaminergic-neurons-and-motor-functions-in-mice
#3
Jin Gyu Choi, Namkwon Kim, In Gyoung Ju, Hyeyoon Eo, Su-Min Lim, Se-Eun Jang, Dong-Hyun Kim, Myung Sook Oh
Recently, studies on the relationship between gut dysbiosis and Parkinson's disease (PD) have increased, but whether a specific gut bacterium may cause PD remains unexplored. Here, we report, for the first time, that a specific gut bacterium directly induces PD symptoms and dopaminergic neuronal damage in the mouse brain. We found that the number of Enterobacteriaceae, particularly Proteus mirabilis, markedly and commonly increased in PD mouse models. Administration of P. mirabilis isolated from PD mice significantly induced motor deficits, selectively caused dopaminergic neuronal damage and inflammation in substantia nigra and striatum, and stimulated α-synuclein aggregation in the brain as well as in the colon...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351884/crucial-role-of-chelatable-iron-in-silver-nanoparticles-induced-dna-damage-and-cytotoxicity
#4
Agnieszka Grzelak, Maria Wojewódzka, Sylwia Meczynska-Wielgosz, Mariusz Zuberek, Dominika Wojciechowska, Marcin Kruszewski
Damage to mitochondria and subsequent ROS leakage is a commonly accepted mechanism of nanoparticle toxicity. However, malfunction of mitochondria results in generation of superoxide anion radical (O2•-), which due to the relatively low chemical reactivity is rather unlikely to cause harmful effects triggered by nanoparticles. We show that treatment of HepG2 cells with silver nanoparticles (AgNPs) resulted in generation of H2O2 instead of O2•-, as measured by ROS specific mitochondrial probes. Moreover, addition of a selective iron chelator diminished AgNPs toxicity...
January 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29351718/good-versus-good-enough-empirical-tests-of-methane-leak-detection-sensitivity-of-a-commercial-infrared-camera
#5
Arvind P Ravikumar, Jingfan Wang, Mike McGuire, Clay S Bell, Daniel Zimmerle, Adam R Brandt
Methane - a key component of natural gas - is a potent greenhouse gas. A key feature of recent methane mitigation policies is the use of periodic leak detection surveys, typically done with optical gas imaging (OGI) technologies. The most common OGI technology is an infrared camera. In this work, we experimentally develop detection probability curves for OGI-based methane leak detection under different environmental and imaging conditions. Controlled single blind leak detection tests show that the median detection limit (50% detection likelihood) for FLIR-camera based OGI technology is about 20 g CH4/h at an imaging distance of 6 m, an order of magnitude higher than previously reported estimates of 1...
January 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29351406/interleukin-6-promotes-a-sustained-loss-of-endothelial-barrier-function-via-janus-kinase-mediated-stat3-phosphorylation-and-de-novo-protein-synthesis
#6
Hiba Alsaffar, Nina Martino, Joshua P Garrett, Alejandro P Adam
Vascular leakage is a hallmark of the inflammatory response. Acute changes in endothelial permeability are due to post-translational changes in intercellular adhesion and cytoskeleton proteins. However, little is known about the mechanisms leading to long-term changes in vascular permeability. Here, we show that Interleukin-6 (IL-6) promotes an increase in endothelial monolayer permeability that lasts over 24 h and demonstrate that activation of Src and MEK/Erk pathways are required only for short-term increases in permeability, being dispensable after 2 h...
January 10, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29350156/dengue-associated-posterior-reversible-encephalopathy-syndrome-vietnam
#7
Nguyen Thi Hoang Mai, Nguyen Hoan Phu, Ho Dang Trung Nghia, Tran My Phuong, Du Trong Duc, Nguyen Van Vinh Chau, Bridget Wills, Choie Cheio Tchoyoson Lim, Guy Thwaites, Cameron Paul Simmons, Sophie Yacoub
Dengue can cause neurologic complications in addition to the more common manifestations of plasma leakage and coagulopathy. Posterior reversible encephalopathy syndrome has rarely been described in dengue, although the pathophysiology of endothelial dysfunction likely underlies both. We describe a case of dengue-associated posterior reversible encephalopathy syndrome and discuss diagnosis and management.
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29350001/-analysis-of-complications-of-percutaneous-endoscopic-lumbar-discectomy
#8
Ke-Lun Huang, Hong-Lin Teng, Min-Yu Zhu, Jing Wang, Chi Li, Yu Wang
OBJECTIVE: To analyze the complications of lumbar intervertebral disc herniation treated with percutaneous endoscopic lumbar discectomy(PELD), and discuss how to avoid these complications. METHODS: The data of 132 patients with lumbar intervertebral disc herniation underwent PELD from October 2013 and June 2015 were retrospectively analyzed, including 85 males and 47 females with an average age of 42.9 years old. There were 6 cases of L₃,₄, 68 of L₄,₅ and 58 of L₅S₁...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29350000/-percutaneous-vertebroplasty-and-open-vertebroplasty-for-metastatic-spinal-tumor
#9
Xi-Jiang Zhao, Xin-Sheng Qi, Zhi-Xiang Mao, Quan-Ming Wang, Xiang-Bin Gao, Xian-Jun Zhang
OBJECTIVE: To explore the clinical application and therapeutic effect of percutaneous vertebroplasty(PVP) and open vertebroplasty for metastatic spinal tumor. METHODS: The clinical data of 126 patients with metastatic spinal tumor underwent surgery and obtained follow-up from January 2012 to March 2016 were retrospectively analyzed. These 126 cases were divided into two groups according to different operative methods. The metastatic tumor of 43 cases encroached vertebral canal oppressing spinal cord and nerve root, they were treated with open operation(open vertebroplasty group);and other 83 cases without obviously spinal cord or nerve root compression, or unfit for open operation, were treated with PVP (percutaneous vertebroplasty group) ...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349568/class-iii-bacteriocin-helveticin-m-causes-sublethal-damage-on-target-cells-through-impairment-of-cell-wall-and-membrane
#10
Zhilan Sun, Xiaomeng Wang, Xinxiao Zhang, Haihong Wu, Ye Zou, Pengpeng Li, Chong Sun, Weimin Xu, Fang Liu, Daoying Wang
Helveticin-M, a novel Class III bacteriocin produced by Lactobacillus crispatus exhibited an antimicrobial activity against Staphylococcus aureus, S. saprophyticus, and Enterobacter cloacae. To understand how Helveticin-M injured target cells, Helveticin-M was cloned and heterologously expressed in Escherichia coli. Subsequently, the cell wall organization and cell membrane integrity of target cells were determined. The mechanism of cellular damage differed according to bacterial species. Based on morphology analysis, Helveticin-M disrupted the cell wall of Gram-positive bacteria and disorganized the outer membrane of Gram-negative bacteria, therefore, altering surface structure...
January 18, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29349557/a-rare-ocular-complication-of-neisseria-gonorrhoeae
#11
Thiago Gonçalves Dos Santos Martins, Ana Luiza Fontes de Azevedo Costa
BACKGROUND: Spontaneous formation of subconjunctival filtering blebs is rare and has been observed after penetrating ocular surgery, in association with connective tissue diseases and inflammatory conditions. METHOD: We describe here a case of a spontaneous formation of subconjunctival filtering bleb as sequelae of gonococcal conjunctivitis in an adult patient. RESULTS: Spontaneous filtering bleb is a rare complication of gonococcal conjunctivitis...
January 18, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29348661/highly-efficient-and-stable-inverted-perovskite-solar-cell-employing-pedot-go-composite-layer-as-a-hole-transport-layer
#12
Jae Choul Yu, Ji A Hong, Eui Dae Jung, Da Bin Kim, Soo-Min Baek, Sukbin Lee, Shinuk Cho, Sung Soo Park, Kyoung Jin Choi, Myoung Hoon Song
The beneficial use of a hole transport layer (HTL) as a substitution for poly(3,4-ethlyenedioxythiophene): polystyrene sulfonate (PEDOT:PSS) is regarded as one of the most important approaches for improving the stability and efficiency of inverted perovskite solar cells. Here, we demonstrate highly efficient and stable inverted perovskite solar cells by applying a GO-doped PEDOT:PSS (PEDOT:GO) film as an HTL. The high performance of this solar cell stems from the excellent optical and electrical properties of the PEDOT:GO film, including a higher electrical conductivity, a higher work function related to the reduced contact barrier between the perovskite layer and the PEDOT:GO layer, enhanced crystallinity of the perovskite crystal, and suppressed leakage current...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348453/enhanced-anastomotic-healing-by-daikenchuto-tj-100-in-rats
#13
Toshiaki Wada, Kenji Kawada, Kenjiro Hirai, Kosuke Toda, Masayoshi Iwamoto, Suguru Hasegawa, Yoshiharu Sakai
Daikenchuto (DKT), a traditional Japanese medicine, is widely used to treat various gastrointestinal disorders. This study aimed to investigate whether DKT could promote the anastomotic healing in a rat model. Pedicled colonic segments were made in left colon by ligation of the feeding arteries, and then intestinal continuity was restored. Colonic blood flow was analyzed by using ICG fluorescence imaging: Fmax, Tmax, T1/2, and Slope were calculated. Anastomotic leakage (AL) was found in 6 of 19 rats (31.6%) in the control group, whereas in 1 of 16 rats (6...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29346565/apigenin-induces-cell-shrinkage-in-candida-albicans-by-membrane-perturbation
#14
Heejeong Lee, Eun-Rhan Woo, Dong Gun Lee
Apigenin, a natural flavone, has been well characterized for its their anticarcinogenic property; however, its bioactivity against pathogenic fungi has not been investigated in detail. In the present study, we examined the antifungal activity and mode of action of apigenin. Apigenin inhibited the growth of fungal pathogens, which induced superficial infection and reduced biofilm mass. Three-dimensional flow cytometric analysis demonstrated that apigenin induced morphological changes, especially cell shrinkage, in Candida albicans...
January 16, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29346488/a-subretinal-cell-delivery-method-via-suprachoroidal-access-in-minipigs-safety-and-surgical-outcomes
#15
Marc D de Smet, Jessica L Lynch, Nadine S Dejneka, Michael Keane, I John Khan
Purpose: This study evaluated a new subretinal method for delivery of human or pig umbilical tissue-derived cells (hUTC or pUTC, respectively) using a novel subretinal injection cannula and suprachoroidal approach in Göttingen minipig eyes. hUTC (palucorcel) are currently under development for treating geographic atrophy in humans. Methods: Twenty-four Göttingen minipigs (divided into eight groups) were subretinally administered palucorcel, pUTC, or vehicle. In some cases, fluorescently labeled cells and vehicle were administered...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29345850/effects-of-glutaraldehyde-didecyldimethylammonium-bromide-combined-disinfectant-on-the-cell-surface-of-staphylococcus-aureus
#16
Wenshu Lin, Jialin Yi, Yuelin Zhang, Zhirui Deng, Qin Chen, Bing Niu
AIMS: The effects of a new glutaraldehyde-didecyldimethylammonium bromide combination disinfectant (GD) on the cell surface of Staphylococcus aureus, a representative Gram-positive bacterium, were investigated in this study. METHODS AND RESULTS: Results of bacterial surface structural analysis showed that GD significantly changed the bacterial morphology. The membrane fluidity decreased and outer membrane permeabilization increased after contact with GD. Furthermore, the integrity of the cytoplasmic membrane was destroyed by over 99% after exposure to GD for a short time...
January 18, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29345140/high-efficiency-and-stable-organic-solar-cells-enabled-by-dual-cathode-buffer-layers
#17
Zhaoxiang Huai, Lixin Wang, Yansheng Sun, Rui Fan, Shahua Huang, Xiaohui Zhao, Xiaowei Li, Guangsheng Fu, Shaopeng Yang
Various cathode interface materials have been used in organic solar cells (OSCs) to realize high performance. However, most cathode interface materials have their respective weaknesses in maximizing the efficiency or stability of OSCs. Herein, three kinds of alcohol soluble cathode interfacial materials are combined with bathocuproine (BCP) to serve as multi-functional bilayer cathode buffers for the regular OSCs, and thus greatly enhanced power conversion efficiencies (PCEs) over 10.11%, and significantly improved device stability have been achieved...
January 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29344787/a-novel-fully-covered-double-bump-stent-for-staple-line-leaks-after-bariatric-surgery-a-retrospective-analysis
#18
Thomas C C Boerlage, Gerardus P M Houben, Marcel J M Groenen, Klaas van der Linde, Arnold W J M van de Laar, Marloes Emous, Paul Fockens, Rogier P Voermans
BACKGROUND: Staple line leakage after bariatric surgery can be treated by endoscopic placement of a self-expandable stent. The success rate of stent placement is generally high, but migration is a frequent adverse event that hampers successful treatment. The Niti-S Beta stent is a fully covered double-bump stent that was specifically designed to prevent migration. This study aimed to evaluate the effectiveness and adverse event rate of the Niti-S Beta stent. METHODS: A retrospective study was performed in three high-volume bariatric centers...
January 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29344716/safety-and-effectiveness-of-palliative-tunneled-peritoneal-drainage-catheters-in-the-management-of-refractory-malignant-and-non-malignant-ascites
#19
Jennifer A Knight, Scott M Thompson, Chad J Fleming, Emily C Bendel, Melissa J Neisen, Newton B Neidert, Andrew H Stockland, Haraldur Bjarnason, David A Woodrum
PURPOSE: To determine the safety and effectiveness of tunneled peritoneal catheters in the management of refractory malignant and non-malignant ascites. MATERIALS AND METHODS: An IRB-approved retrospective review was undertaken of patients who underwent ultrasound and fluoroscopy-guided tunneled peritoneal catheter placement for management of refractory malignant or non-malignant ascites between January 1, 2009, and March 14, 2014. RESULTS: A total of 137 patients (76 M/61 F, mean age 62...
January 17, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29344564/endoscopic-ultrasound-guided-needle-based-confocal-laser-endomicroscopy-in-solid-pancreatic-masses-a-prospective-validation-study
#20
John Gásdal Karstensen, Tatiana Cârţână, Codruţa Constantinescu, Silviu Dumitrașcu, Bojan Kovacevic, Pia Klausen, Hazem Hassan, Tobias Wirenfeldt Klausen, Helga Bertani, Manoop S Bhutani, Adrian Săftoiu, Peter Vilmann
Background and study aims:  Endoscopic ultrasound fine-needle aspiration (EUS-FNA) is a keystone in diagnosing and staging of pancreatic masses. Recently, a microfiber that can pass through a 19-gauge needle has been introduced for confocal laser endomicroscopy (nCLE). The aims of this study were to evaluate the diagnostic value and the reproducibility of nCLE criteria for solid malignant lesions. Patients and methods:  This prospective dual-center study included patients with pancreatic masses suspicious of malignancy referred for EUS-FNA...
January 2018: Endoscopy International Open
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