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https://www.readbyqxmd.com/read/27913498/long-term-risk-of-second-malignancy-and-cardiovascular-disease-after-hodgkin-lymphoma-treatment
#1
Flora E van Leeuwen, Andrea K Ng
Long-term survivors of Hodgkin lymphoma (HL) experience several late adverse effects of treatment, with second malignant neoplasms (SMNs) and cardiovascular diseases (CVDs) being the leading causes of death in these patients. Other late effects have also been identified, such as pulmonary dysfunction, endocrinopathies (thyroid dysfunction, infertility), neck muscle atrophy, and persistent fatigue. HL survivors have two- to fourfold increased risks to develop SMNs and CVD compared with the general population...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27876126/regular-sun-exposure-benefits-health
#2
H J van der Rhee, E de Vries, J W Coebergh
Since it was discovered that UV radiation was the main environmental cause of skin cancer, primary prevention programs have been started. These programs advise to avoid exposure to sunlight. However, the question arises whether sun-shunning behaviour might have an effect on general health. During the last decades new favourable associations between sunlight and disease have been discovered. There is growing observational and experimental evidence that regular exposure to sunlight contributes to the prevention of colon-, breast-, prostate cancer, non-Hodgkin lymphoma, multiple sclerosis, hypertension and diabetes...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27860222/late-outcomes-of-adult-survivors-of-childhood-non-hodgkin-lymphoma-a-report-from-the-st-jude-lifetime-cohort-study
#3
Matthew J Ehrhardt, John T Sandlund, Nan Zhang, Wei Liu, Kirsten K Ness, Nickhill Bhakta, Wassim Chemaitilly, Kevin R Krull, Tara M Brinkman, Deborah B Crom, Larry Kun, Sue C Kaste, Gregory T Armstrong, Daniel M Green, Kumar Srivastava, Leslie L Robison, Melissa M Hudson, Daniel A Mulrooney
BACKGROUND: Survivors of childhood non-Hodgkin lymphoma (NHL) are at increased risk for chronic health conditions. The objective of this study was to characterize health conditions, neurocognitive function, and physical performance among a clinically evaluated cohort of 200 childhood NHL survivors. METHOD: Chronic health and neurocognitive conditions were graded as per a modified version of the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) and impaired physical function defined as performance < 10th percentile of normative data...
November 15, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27843428/a-rare-case-of-gastric-variceal-hemorrhage-secondary-to-infiltrative-b-cell-lymphoma
#4
Adrienne Lenhart, Juan Fernandez-Castillo, Keith Mullins, Reena Salgia
Portal hypertension commonly arises in the setting of advanced liver cirrhosis and is the consequence of increased resistance within the portal vasculature. Less commonly, left-sided noncirrhotic portal hypertension can develop in a patient secondary to isolated obstruction of the splenic vein. We present a rare case of left-sided portal hypertension and isolated gastric varices in a patient with large B-cell lymphoma, who was treated with splenic artery embolization. The patient is a 73-year-old male with no previous history of liver disease, who presented with coffee ground emesis and melena...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27836716/activity-and-safety-of-brigatinib-in-alk-rearranged-non-small-cell-lung-cancer-and-other-malignancies-a-single-arm-open-label-phase-1-2-trial
#5
Scott N Gettinger, Lyudmila A Bazhenova, Corey J Langer, Ravi Salgia, Kathryn A Gold, Rafael Rosell, Alice T Shaw, Glen J Weiss, Meera Tugnait, Narayana I Narasimhan, David J Dorer, David Kerstein, Victor M Rivera, Timothy Clackson, Frank G Haluska, David Ross Camidge
BACKGROUND: Anaplastic lymphoma kinase (ALK) gene rearrangements are oncogenic drivers of non-small-cell lung cancer (NSCLC). Brigatinib (AP26113) is an investigational ALK inhibitor with potent preclinical activity against ALK mutants resistant to crizotinib and other ALK inhibitors. We aimed to assess brigatinib in patients with advanced malignancies, particularly ALK-rearranged NSCLC. METHODS: In this ongoing, single-arm, open-label, phase 1/2 trial, we recruited patients from nine academic hospitals or cancer centres in the USA and Spain...
November 7, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27801773/chemotherapy-associated-posterior-reversible-encephalopathy-syndrome-a-case-report-and-review-of-the-literature
#6
Joan How, Margaret Blattner, Susan Fowler, Andrea Wang-Gillam, Suzanne E Schindler
INTRODUCTION: There are increasing reports of posterior reversible encephalopathy syndrome (PRES) associated with the use of chemotherapeutic agents. Recognition of PRES is crucial given its reversibility with appropriate supportive management. We report a patient presenting with PRES after treatment with Rituximab, Cyclophosphamide, Hydroxydaunorubicin/Adriamycin, Oncovin/Vincristine, Prednisone (R-CHOP) and intrathecal methotrexate. We also perform a systematic review of the literature on chemotherapy-associated PRES...
November 2016: Neurologist
https://www.readbyqxmd.com/read/27687667/-rituximab-combined-with-epoch-regimen-for-treatment-of-diffuse-large-b-cell-lymphoma-of-the-gastrointestinal-tract-analysis-of-4-cases
#7
Rong-Hua Hu, Wan-Ling Sun, Hong Zhao, Wu-Han Hui, Yi-Xian Guo, Sui-Gui Wan, Li Su
We treated 4 with a diagnosis of diffuse large B cell lymphoma involving the gastrointestinal tract with rituximab combined with adjusted dose EPOCH (R-DA-EPOCH) scheme based on a comprehensive analysis of the onset process, clinical and pathological features, and prognosis of the patients, and evaluated their treatment response. Complete remission (CR) was achieved in 3 patients after the treatment and 1 patient with diabetes and hypertension died due to severe infection. R-DA-EPOCH regimen as the first-line treatment of gastrointestinal diffuse large B cell lymphoma has a good short-term efficacy, but its long-term efficacy awaits further evaluation in future studies with larger sample sizes...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27639911/-routine-screening-of-splenic-or-portal-vein-thrombosis-after-splenectomy
#8
A Bouvier, M Gout, S Audia, C Chalumeau, P Rat, O Deballon
BACKGROUND: Portal and/or splenic vein thrombosis (PSVT) is common after splenectomy. It can be a life-threatening complication, with a risk of bowel ischemia and portal hypertension. An early diagnosis allows an effective medical treatment and prevents life-threatening complications. There is no consensus regarding the benefit of systematic screening of patients after splenectomy for PSVT. We started in January 2012 a routine screening of PSVT after elective splenectomy. The aim of this study was to assess this policy...
September 14, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27593799/computerized-tomography-guided-stereotactic-biopsy-of-intracranial-lesions-report-of-consecutive-500-cases
#9
Songül Meltem Can, Osman Nuri Türkmenoğlu, Canan Tanik, Ender Uysal, Barış Özöner, Saime Ayça Kaldirimoğlu, Ahmet Murat Müslüman, Adem Yilmaz, Halit Çavuşoğlu, Çiçek Bayindir, Yunus Aydin
AIM: CT-guided stereotactic brain biopsy has been performed in our clinic since March 1998. In this prospective study, we examined the patient data undergoing stereotactic biopsy and the results of biopsies in consecutive 500 patients. MATERIAL AND METHODS: Between the dates of March 1998 and January 2015, CT guided stereotactic biopsies were performed by using the Leksell stereotactic frame system (Elekta Instruments EU, Sweden) in 500 patients. A total of 512 procedures were performed in patients consisting of 184 females (36...
January 25, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27587945/bcl-2-bcl-xl-and-p-akt-are-involved-in-neuroprotective-effects-of-transcription-factor-brn3b-in-an-ocular-hypertension-rat-model-of-glaucoma
#10
Nitasha R Phatak, Dorota L Stankowska, Raghu R Krishnamoorthy
PURPOSE: Brn3b is a class IV POU domain transcription factor that plays an important role in the development of retinal ganglion cells (RGCs), RGC survival, and particularly axon growth and pathfinding. Our previous study demonstrated that recombinant adenoassociated virus serotype 2 (rAAV-2)-mediated overexpression of Brn3b in RGCs promoted neuroprotection in a rodent model of glaucoma. However, the mechanisms underlying neuroprotection of RGCs in rats overexpressing Brn3b in animal models of glaucoma remain largely unknown...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27564390/comorbidities-in-patients-with-primary-sj%C3%A3-gren-s-syndrome-and-systemic-lupus-erythematosus-a-comparative-registries-based-study
#11
Iñigo Rúa-Figueroa, Mónica Fernández Castro, José L Andreu, Carlos Sanchez-Piedra, Víctor Martínez-Taboada, Alejandro Olivé, Javier López-Longo, José Rosas, María Galindo, Jaime Calvo-Alén, Antonio Fernández-Nebro, Fernando Alonso, Beatriz Rodríguez-Lozano, Jesús Alberto García Vadillo, Raúl Menor, Francisco Javier Narváez, Celia Erausquin, Ángel García-Aparicio, Eva Tomero, Sara Manrique-Arija, Loreto Horcada, Esther Uriarte, Susana Gil, Ricardo Blanco, Ruth López-González, Alina Boteanu, Mercedes Freire, Carlos Galisteo, Manuel Rodríguez-Gómez, Elvira Díez-Álvarez, José M Pego-Reigosa
OBJECTIVE: To compare the prevalence of the main comorbidities in 2 large cohorts of patients with primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), with a focus on cardiovascular (CV) diseases. METHODS: This was a cross-sectional multicenter study where the prevalence of more relevant comorbidities in 2 cohorts was compared. Patients under followup from SJOGRENSER (Spanish Rheumatology Society Registry of Primary SS) and RELESSER (Spanish Rheumatology Society Registry of SLE), and who fulfilled the 2002 American-European Consensus Group and 1997 American College of Rheumatology classification criteria, respectively, were included...
August 26, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27462355/the-effect-of-sildenafil-on-right-ventricular-remodeling-in-a-rat-model-of-monocrotaline-induced-right-ventricular-failure
#12
Hyun Kyung Bae, Hyeryon Lee, Kwan Chang Kim, Young Mi Hong
PURPOSE: Pulmonary arterial hypertension (PAH) leads to right ventricular failure (RVF) as well as an increase in pulmonary vascular resistance. Our purpose was to study the effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline (MCT)-induced RVF. METHODS: The rats were distributed randomly into 3 groups. The control (C) group, the monocrotaline (M) group (MCT 60 mg/kg) and the sildenafil (S) group (MCT 60 mg/kg+ sildenafil 30 mg/kg/day for 28 days)...
June 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27458003/brentuximab-vedotin-and-avd-followed-by-involved-site-radiotherapy-in-early-stage-unfavorable-risk-hodgkin-lymphoma
#13
Anita Kumar, Carla Casulo, Joachim Yahalom, Heiko Schöder, Paul M Barr, Philip Caron, April Chiu, Louis S Constine, Pamela Drullinsky, Jonathan W Friedberg, John F Gerecitano, Audrey Hamilton, Paul A Hamlin, Steven M Horwitz, Alexandra G Jacob, Matthew J Matasar, Gianna N McArthur, Susan J McCall, Alison J Moskowitz, Ariela Noy, Maria L Palomba, Carol S Portlock, David J Straus, Nicholas VanderEls, Stephanie L Verwys, Joanna Yang, Anas Younes, Andrew D Zelenetz, Zhigang Zhang, Craig H Moskowitz
This multicenter pilot study assessed the safety and efficacy of brentuximab vedotin (BV) and AVD (adriamycin, vinblastine, and dacarbazine) followed by 30 Gy involved site radiation therapy (ISRT). Patients with newly diagnosed, early stage classical Hodgkin lymphoma (HL) with unfavorable-risk features were treated with 4 cycles of BV and AVD. Patients who achieved a negative positron emission tomography (PET) scan (Deauville score of 1-3) received 30 Gy ISRT. Thirty patients received treatment and were assessable for toxicity...
September 15, 2016: Blood
https://www.readbyqxmd.com/read/27455221/qingxuan-jiangya-decoction-reverses-vascular-remodeling-by-inducing-vascular-smooth-muscle-cell-apoptosis-in-spontaneously-hypertensive-rats
#14
Fei Xiao, Fei He, Hongwei Chen, Shan Lin, Aling Shen, Youqin Chen, Jianfeng Chu, Jun Peng
Qingxuan Jiangya Decoction (QXJYD), a traditional Chinese medicine formula prescribed by academician Ke-ji Chen, has been used in China to clinically treat hypertension for decades of years. However, the molecular mechanisms of its action remain largely unknown. In this study, we examined the therapeutic efficacy of QXJYD against elevated systolic blood pressure in the spontaneously hypertensive rat (SHR) model, and investigated the underlying molecular mechanisms. We found that oral administration of QXJYD significantly reduced the elevation of systolic blood pressure in SHR but had no effect on body weight change...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27440138/case-report-of-subcutaneous-panniculitis-like-t-cell-lymphoma-complicated-by-eyelid-swelling
#15
Ryuya Hashimoto, Michihiro Uchiyama, Takatoshi Maeno
BACKGROUND: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare, highly malignant, extranodal lymphoma that preferentially infiltrates into subcutaneous adipose tissue. No case of SPTCL with the earliest symptoms occurring in the eye region has been reported. We report a case of SPTCL complicated by eyelid swelling. CASE PRESENTATION: A 19-year-old Japanese man presented with worsening left eyelid swelling. The patient's best-corrected visual acuity (BCVA) was 0...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27434101/exercise-training-attenuates-dexamethasone-induced-hypertension-by-improving-autonomic-balance-to-the-heart-sympathetic-vascular-modulation-and-skeletal-muscle-microcirculation
#16
Naiara A Herrera, Isley Jesus, André L Shinohara, Thiago J Dionísio, Carlos F Santos, Sandra L Amaral
OBJECTIVE: Although aerobic exercise training has been recommended as nonpharmacological treatment of high blood pressure, the mechanisms of training-induced blood pressure lowering effects in dexamethasone (DEX)-induced hypertension remain unclear. Therefore, the aim of this study was to investigate the preventive role of exercise training in counteracting DEX-induced hypertension. METHODS: Rats were submitted to aerobic exercise training for 8 weeks or kept sedentary and then treated with DEX (50 μg/kg/day, s...
October 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27419050/angiotensin-ii-type-1-receptor-blocker-telmisartan-induces-apoptosis-and-autophagy-in-adult-t-cell-leukemia-cells
#17
Tomohiro Kozako, Shuhei Soeda, Makoto Yoshimitsu, Naomichi Arima, Ayako Kuroki, Shinya Hirata, Hiroaki Tanaka, Osamu Imakyure, Nanako Tone, Shin-Ichiro Honda, Shinji Soeda
Adult T-cell leukemia/lymphoma (ATL), an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukemia virus (HTLV-1), requires new treatments. Drug repositioning, reuse of a drug previously approved for the treatment of another condition to treat ATL, offers the possibility of reduced time and risk. Among clinically available angiotensin II receptor blockers, telmisartan is well known for its unique ability to activate peroxisome proliferator-activated receptor-γ, which plays various roles in lipid metabolism, cellular differentiation, and apoptosis...
May 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27413173/bortezomib-alleviates-experimental-pulmonary-hypertension-by-regulating-intracellular-calcium-homeostasis-in-pasmcs
#18
Jun Zhang, Wenju Lu, Yuqin Chen, Qian Jiang, Kai Yang, Meichan Li, Ziyi Wang, Xin Duan, Lei Xu, Haiyang Tang, Dejun Sun, Jian Wang
The ubiquitin-proteasome system is considered to be the key regulator of protein degradation. Bortezomib (BTZ) is the first proteasome inhibitor approved by the US Food and Drug Administration for treatment of relapsed multiple myeloma and mantle cell lymphoma. Recently, BTZ treatment was reported to inhibit right ventricular hypertrophy and vascular remodeling in hypoxia-exposed and monocrotaline-injected rats. However, the underlying mechanisms remain poorly understood. We previously confirmed that hypoxia-elevated basal intracellular Ca(2+) concentration ([Ca(2+)]i) and store-operated Ca(2+) entry (SOCE) in pulmonary artery smooth muscle cells (PASMCs) are involved in pulmonary vascular remodeling...
September 1, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27308085/papilledema-due-to-mirtazapine
#19
Mehmet Emin Ceylan, Alper Evrensel, Gökçe Cömert
BACKGROUND: Mirtazapine is a tetracyclic antidepressant that enhances both noradrenergic and serotonergic transmission. The most common cause of papilledema is increased intracranial pressure due to brain tumor. Also it may occur as a result of idiopathic intracranial hypertension (IIH, pseudo tumor cerebri). Moreover, papilledema may also develop due to retinitis, vasculitis, Graves' disease, hypertension, leukemia, lymphoma, diabetes mellitus and radiation. CASE REPORT: In this article, a patient who developed papilledema while under treatment with mirtazapine (30 mg/day) for two years and recovered with termination of mirtazapine treatment was discussed to draw the attention of clinicians to this side effect of mirtazapine...
May 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27303306/electrophysiological-mechanisms-of-bay%C3%A3-s-syndrome-insights-from-clinical-and-mouse-studies
#20
REVIEW
Gary Tse, Eric Tsz Him Lai, Jie Ming Yeo, Bryan P Yan
Bayés syndrome is an under-recognized clinical condition characterized by inter-atrial block (IAB). This is defined electrocardiographically as P-wave duration > 120 ms and can be categorized into first, second and third degree IAB. It can be caused by inflammatory conditions such as systemic sclerosis and rheumatoid arthritis, abnormal protein deposition in cardiac amyloidosis, or neoplastic processes invading the inter-atrial conduction system, such as primary cardiac lymphoma. It may arise transiently during volume overload, autonomic dysfunction or electrolyte disturbances from vomiting...
2016: Frontiers in Physiology
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