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Stroke in young age

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https://www.readbyqxmd.com/read/29224651/role-of-doppler-echocardiography-for-cardiac-output-assessment-in-fontan-patients
#1
Alexander Egbe, Arooj R Khan, Sana F Khan, Nandan S Anavekar, Sameh M Said, Philip M Young, Emmanuel Akintoye, William R Miranda, Mohamad N Al-Otaibi, Gruschen R Veldtman, Heidi M Connolly
BACKGROUND: To determine (1) correlation between Doppler stroke volume index (SVI) and cardiac magnetic resonance imaging (CMRI) SVI and (2) association between Doppler SVI and Fontan-associated diseases (FAD) and Fontan failure. METHODS: Review of Fontan patients who underwent same-day CMRI and transthoracic echocardiography (TTE), 2005 to 2015. We defined FAD as cardiac thrombus, protein-losing enteropathy, arrhythmia, and hospitalization for heart failure. Fontan failure was defined as Fontan conversion or revision, heart transplantation or listing, or death...
January 2018: American Heart Journal
https://www.readbyqxmd.com/read/29223437/outcomes-in-elderly-and-young-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-with-bivalirudin-versus-heparin-pooled-analysis-from-the-euromax-and-horizons-ami-trials
#2
Khalid Qaderdan, Gerrit-Jan A Vos, Thomas McAndrew, Philippe Gabriel Steg, Christian W Hamm, Arnoud Van't Hof, Roxana Mehran, Efthymios N Deliargyris, Debra Bernstein, Gregg W Stone, Jurriën M Ten Berg
BACKGROUND: Since older age is a strong predictor of not only bleeding but also of ischemic events, understanding the risk:benefit profile of bivalirudin in the elderly undergoing primary percutaneous coronary intervention (pPCI) for ST-segment elevation (STEMI) is important. For this, we aim to compare elderly with young patients, who all underwent pPCI for STEMI and randomly received either bivalirudin or heparin. METHODS: We performed a patient-level pooled analysis (n=5800) of two large randomized trials...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29218790/embolic-strokes-of-undetermined-source-in-young-adults-baseline-characteristics-and-long-term-outcome
#3
Nicolas Martinez-Majander, Karoliina Aarnio, Jani Pirinen, Tuomas Lumikari, Tuomo Nieminen, Mika Lehto, Juha Sinisalo, Markku Kaste, Turgut Tatlisumak, Jukka Putaala
BACKGROUND: Embolic strokes of undetermined source (ESUS) is a recent entity, not yet thoroughly investigated in young stroke patients. We compared clinical characteristics and long-term risks of vascular events and all-cause mortality between young-onset ESUS and other etiological subgroups. METHODS: Among the 1008 patients aged 15 to 49 years with first-ever ischemic stroke in Helsinki Young Stroke Registry, we identified ESUS patients, and defined primary endpoints as recurrent stroke, composite vascular events, and all-cause mortality...
December 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29191528/web-vessels-literature-review-and-neurointerventional-management
#4
Benedito J A Pereira, Ulysses Caus Batista, Renato Tavares Tosello, Igor Neia Stro Her, Alex Machado Baeta, Ronie Leo Piske
OBJECTIVES: The aim of this study is to describe twenty-seven patients with thirty-two WVs from our practice as well as provide a review of the literature regarding imaging diagnostics, clinical presentation and treatment of these lesions. METHODS: A Medline search was performed using combinations of the following words: stroke in young adults, web, recurrent stroke, diaphragm-like, atypical fibromuscular hyperplasia, atypical fibromuscular dysplasia, septal fibromuscular dysplasia, septa, diaphragms, pseudo-valvular folds and carotid diaphragm...
November 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29189108/return-to-work-after-young-stroke-a-systematic-review
#5
Jodi D Edwards, Arunima Kapoor, Elizabeth Linkewich, Richard H Swartz
Background The incidence of stroke in young adults is increasing. While many young survivors are able to achieve a good physical recovery, subtle dysfunction in other domains, such as cognition, often persists, and could affect return to work. However, reported estimates of return to work and factors affecting vocational outcome post-stroke vary greatly. Aims The aims of this systematic review were to determine the frequency of return to work at different time points after stroke and identify predictors of return to work...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29172921/immunity-and-inflammation-predictors-for-short-term-outcome-of-stroke-in-young-adults
#6
Xiaoqing Zhou, Fang Yu, Xianjing Feng, Junyan Wang, Zhibin Li, Qiong Zhan, Jian Xia
BACKGROUND: The current study was conducted to identify independent predictors of severity and short-term outcome of first-ever ischemic stroke in young adults. METHODS: We retrospectively enrolled 325 consecutive patients aged 18-49 years with first-ever ischemic stroke admitted to our center between April 2013 and June 2015. Variables were systematically registered and compared between patients with different neurological severity (mild stroke: National Institutes of Health Stroke Scale [NIHSS]≤8 and severe stroke:>8) and different stroke outcome (favorable: modified Rankin scale score 0-2 and unfavorable: 3-5 or death) at 14 days after stroke onset...
November 27, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29172008/effects-of-cerebrolysin-on-nerve-growth-factor-system-in-the-aging-rat-brain
#7
Mikhail Stepanichev, Mikhail Onufriev, Viktor Aniol, Sofia Freiman, Hemma Brandstaetter, Stefan Winter, Natalia Lazareva, Alla Guekht, Natalia Gulyaeva
BACKGROUND: Aging is associated with some cognitive decline and enhanced risk of development of neurodegenerative diseases. It is assumed that altered metabolism and functions of neurotrophin systems may underlie these age-related functional and structural modifications. CerebrolysinTM (CBL) is a neuropeptide mixture with neurotrophic effects, which is widely used for the treatment of stroke and traumatic brain injury patients. It is also evident that CBL has an overall beneficial effect and a favorable benefit-risk ratio in patients with dementia...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29171211/a-prospective-survey-of-atrial-fibrillation-management-for-real-world-guideline-adherence-comparison-study-of-drugs-for-symptom-control-and-complication-prevention-of-atrial-fibrillation-code-af-registry
#8
Hyeongsoo Kim, Tae Hoon Kim, Myung Jin Cha, Jung Myung Lee, Junbeom Park, Jin Kyu Park, Ki Woon Kang, Jaemin Shim, Jae Sun Uhm, Jun Kim, Hyung Wook Park, Eue Keun Choi, Jin Bae Kim, Changsoo Kim, Young Soo Lee, Boyoung Joung
BACKGROUND AND OBJECTIVES: The aging population is rapidly increasing, and atrial fibrillation (AF) is becoming a significant public health burden in Asia, including Korea. This study evaluated current treatment patterns and guideline adherence of AF treatment. METHODS: In a prospective observational registry (COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation [CODE-AF] registry), 6,275 patients with nonvalvular AF were consecutively enrolled between June 2016 and April 2017 from 10 tertiary hospitals in Korea...
October 17, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29165288/treatment-related-noncontiguous-radiologic-changes-in-children-with-diffuse-intrinsic-pontine-glioma-treated-with-expanded-irradiation-fields-and-antiangiogenic-therapy
#9
Zoltan Patay, Thomas E Merchant, Rosa Nguyen, Christopher R Pierson, Arzu Onar-Thomas, Alberto Broniscer
PURPOSE: We previously reported the cases of 3 children with diffuse intrinsic pontine glioma (DIPG) in whom noncontiguous treatment-related abnormalities (NCTRAs) developed in the brain after expanded-field radiation therapy (RT). To investigate the occurrence and putative mechanism of NCTRAs, we reviewed brain magnetic resonance imaging studies of patients with DIPG treated in 2 consecutive phase I clinical trials (trials 1 and 2). METHODS AND MATERIALS: The 55 children included in these trials received small-molecule inhibitors: vandetanib in trial 1 (n=32; mean age 6...
December 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29153576/coronary-artery-calcium-and-long-term%C3%A2-risk-of-death-myocardial%C3%A2-infarction-and-stroke-the-walter-reed-cohort-study
#10
Joshua D Mitchell, Robert Paisley, Patrick Moon, Eric Novak, Todd C Villines
OBJECTIVES: This study aimed to assess the long-term risk of death and atherosclerotic cardiovascular disease (ASCVD) outcomes, including stroke, in a real-world cohort that underwent coronary artery calcium (CAC) scoring. BACKGROUND: Large-scale, long-term studies assessing the independent relationship of CAC for prediction of ASCVD events, to include stroke, in young, low-risk patients are uncommon outside of the clinical trial setting. METHODS: A total of 23,637 consecutive subjects without ASCVD who underwent CAC scoring from 1997 to 2009 were studied...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29145824/observations-on-significant-hemodynamic-changes-caused-by-a-high-concentration-of-epidurally-administered-ropivacaine-correlation-and-prediction-study-of-stroke-volume-variation-and-central-venous-pressure-in-thoracic-epidural-anesthesia
#11
Jeong-Min Hong, Hyeon Jeong Lee, Young-Jae Oh, Ah Rhem Cho, Hyae Jin Kim, Do-Won Lee, Wang-Seok Do, Jae-Young Kwon, Haekyu Kim
BACKGROUND: Thoracic epidural anesthesia (TEA) exacerbates hypotension due to peripheral vasodilator effects following the use of general anesthetics. This study aimed to compare the hemodynamic changes caused by three different concentrations of epidural ropivacaine and to evaluate the performance of the stroke-volume variation (SVV) and central venous pressure (CVP) during TEA with general anesthesia. METHODS: A total of 120 patients were administered 8 mL of ropivacaine solution via epidural injection, following randomization into one of three groups based on the concentration of ropivacaine in the study solution: 0...
November 16, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29136635/stroke-among-rheumatoid-arthritis-patients-does-age-matter-a-real-life-study
#12
Shmuel Tiosano, Yarden Yavne, Omer Gendelman, Abdulla Watad, Doron Comaneshter, Yehuda Shoenfeld, Arnon D Cohen, Daniela Amital
BACKGROUND/AIMS: Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune disease that affects the joints and it is known to be associated with cardiovascular morbidity. However, the association between RA and stroke among different age groups has not been explored. The objective of our study was to evaluate the association between RA and stroke in different age strata. METHODS: Cross-sectional study, utilizing the database of Israel's largest healthcare provider...
November 14, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29134608/factors-that-may-account-for-cardiovascular-risk-reduction-with-a-dipeptidyl-peptidase-4-inhibitor-vildagliptin-in-young-patients-with-type-2-diabetes-mellitus
#13
Marc Evans, Plamen Kozlovski, Päivi M Paldánius, James E Foley, Vaishali Bhosekar, Carmen Serban, Angelo Avogaro
INTRODUCTION: In a meta-analysis, we observed a significant 37% relative risk reduction in prospectively adjudicated major adverse cardiac events [MACEs, comprising of non-fatal myocardial infarction, non-fatal stroke, cardiovascular (CV) death] with vildagliptin vs. comparators in younger (< 65 years) patients with type 2 diabetes mellitus (T2DM), while the risk was similar in older patients (≥ 65 years). We carried out an exploratory analysis to identify the patient characteristics and on-treatment effects that may have contributed to the different outcomes in the two age groups...
November 13, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29132836/prevalence-of-fabry-disease-in-young-patients-with-stroke-in-argentina
#14
Ricardo C Reisin, Julieta Mazziotti, Luciana León Cejas, Alberto Zinnerman, Pablo Bonardo, Manuel Fernández Pardal, Alejandra Martínez, Patricia Riccio, Sebastián Ameriso, Eduardo Bendersky, Pedro Nofal, Patricia Cairola, Lorena Jure, Andrea Sotelo, Paula Rozenfeld, Romina Ceci, Ignacio Casas-Parera, Analía Sánchez Luceros
BACKGROUND: Fabry disease (FD) is an underdiagnosed cause of stroke in young adults, but the frequency of this association is largely unknown. We estimated the prevalence of FD in a nationwide cohort of young adults who had stroke and transient ischemic attack (TIA) in Argentina. METHODS: This was a prospective, multicenter study of stroke and FD in young adults (18-55 years) conducted in Argentina between 2011 and 2015. Patients were enrolled if they had had a TIA or an ischemic or hemorrhagic stroke within the previous 180 days...
November 10, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29129258/long-term-outcomes-of-bypass-grafting-versus-drug-eluting-stenting-for-left-main-coronary-artery-disease-results-from-the-iris-main-registry
#15
MULTICENTER STUDY
Pil Hyung Lee, Jong-Young Lee, Cheol Whan Lee, Seungbong Han, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Seung-Jung Park
There are limited data on comparative outcomes and its determinants following coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI) with drug-eluting stents (DES) for left main coronary artery disease (LMCAD) in a real-world setting. METHODS: A total of 3,504 consecutive patients with LMCAD treated with CABG (n=1,301) or PCI with DES (n=2,203) from the IRIS-MAIN registry were analyzed. The relative treatment effect of one strategy over another was assessed by propensity-score matching method...
November 2017: American Heart Journal
https://www.readbyqxmd.com/read/29127059/hypertension-and-cardiovascular-risk-general-aspects
#16
REVIEW
Sverre E Kjeldsen
Hypertension is the strongest or one of the strongest risk factors for almost all different cardiovascular diseases acquired during life, including coronary disease, left ventricular hypertrophy and valvular heart diseases, cardiac arrhythmias including atrial fibrillation, cerebral stroke and renal failure. The continuous relationship between blood pressure and cardiovascular and renal events makes the distinction between high normal blood pressure and hypertension based on arbitrary cut-off values for blood pressures...
November 7, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29118799/optional-endovascular-therapy-of-dissecting-posterior-cerebral-artery-aneurysm
#17
Mohamed Wael Osman, Krzysztof Kadziolka, Laurent Peirot
BACKGROUND: Posterior cerebral artery aneurysms are uncommon, with an occurrence rate of less than 1% of intracranial aneurysms. They have various shapes, including saccular and fusiform. Dissecting aneurysms may occur in distal posterior cerebral artery and they may affect the whole artery. Endovascular therapy is considered as a safe method of treatment and there are different techniques for endovascular therapy. SUMMARY: Posterior cerebral artery aneurysms are uncommon...
October 2017: Interventional Neurology
https://www.readbyqxmd.com/read/29114921/association-of-early-left-ventricular-dysfunction-with-advanced-magnetic-resonance-white-matter-and-gray-matter-brain-measures-the-cardia-study
#18
Anderson C Armstrong, Majon Muller, Bharath Ambale-Ventakesh, Michael Halstead, Satoru Kishi, Nick Bryan, Stephen Sidney, Luís C L Correia, Samuel S Gidding, Lenore J Launer, João A C Lima
INTRODUCTION: Relations between heart failure and clinically manifested stroke are well known, but the associations between heart and brain early abnormalities are not totally clear. AIMS: We explore relations of subclinical brain abnormalities with early cardiac dysfunction in a large healthy middle-aged biracial cohort. METHODS: The CARDIA study enrolled 5115 young adults aged 18-30 years at baseline (1985-1986). We assessed 719 Caucasian and African American participants of the CARDIA study, with echocardiograms and brain MRI at follow-up year 25 (2010-2011)...
November 8, 2017: Echocardiography
https://www.readbyqxmd.com/read/29112057/game-responses-during-young-padel-match-play-age-and-gender-comparisons
#19
Sergio García-Benítez, Javier Courel-Ibáñez, Txomin Pérez-Bilbao, José Luis Felipe
The purpose of the present study was to assess match activity profile and temporal structure in U-16 and U-18 male and female padel players from the 2014 Spanish Youth National Championship. A total of 1670 rallies from 12 matches were recorded through systematic observation. Variables pertaining to game and point duration, rest interval time, number of strokes per rally, and match total duration were registered. Current findings show significant influences of age and gender on game demands in youth padel players, strengthen the importance of knowing specific game characteristics during formative stages for training accordingly...
October 30, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29110948/bioprosthetic-aortic-valve-replacement-revisiting-prosthesis-choice-in-patients-younger-than-50%C3%A2-years-old
#20
Samuel R Schnittman, David H Adams, Shinobu Itagaki, Nana Toyoda, Natalia N Egorova, Joanna Chikwe
OBJECTIVE: Aortic prosthesis choice is controversial in young adults because robust comparative outcome data are lacking. We therefore compared mortality and morbidity in young adults after bioprosthetic versus mechanical aortic valve replacement. METHODS: This was a retrospective analysis of 5111 patients aged 18 to 50 years undergoing primary aortic valve replacement in California and New York State from 1997 to 2006. Median follow-up time was 11.8 years (maximum 18...
September 13, 2017: Journal of Thoracic and Cardiovascular Surgery
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