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https://www.readbyqxmd.com/read/29792424/comprehensive-investigation-into-luminescent-properties-of-ir-iii-complexes-an-integrated-computational-study-of-radiative-and-nonradiative-decay-processes
#1
Yu Wang, Peng Bao, Jian Wang, Ran Jia, Fu-Quan Bai, Hong-Xing Zhang
A comprehensive and concrete exploration into the deactivation mechanisms of luminescent materials is imperative, with the improvement of simulating and computing technology. In this study, an integrated calculation scheme is employed on five Ir(III) complexes for thorough investigation of their photophysical properties, including radiative ( kr ) and nonradiative ( knr ) decay rates. As a most famous Ir(III) complex with superior quantum efficiency, fac-Ir(ppy)3 herein serves as a reference relative to the other four β-diketonate complexes...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792290/the-use-of-mobile-health-applications-to-improve-patient-experience-cross-sectional-study-in-chinese-public-hospitals
#2
Chuntao Lu, Yinhuan Hu, Jinzhu Xie, Qiang Fu, Isabella Leigh, Samuel Governor, Guanping Wang
BACKGROUND: The proliferation of mobile health apps has greatly changed the way society accesses the health care industry. However, despite the widespread use of mobile health apps by patients in China, there has been little research that evaluates the effect of mobile health apps on patient experience during hospital visits. OBJECTIVE: The purpose of our study was to examine whether the use of mobile health apps improves patient experience and to find out the difference in patient experience between users and nonusers and the characteristics associated with the users of these apps...
May 23, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29791924/return-to-sport-after-acl-surgery-a-comparison-between-two-different-reconstructive-techniques
#3
Matteo Baldassarri, Luca Perazzo, Diego Ghinelli, Marco Ricciarelli, Federico Pilla, Roberto Buda
The anterior cruciate ligament reconstruction (ACLR) has become a very common surgical procedure. One of the main success indicators of the surgical procedure is the return to preinjury sporting level. In recent years, reconstructive techniques have been geared toward less morbidity and optimized ligaments process to speed up the recovery of sports activity. This study compares clinical and imaging data, to evaluate the timing of return to sport, of two populations undergoing ACLR using two different techniques: ACLR with hamstring maintaining tibial insertion (MHG) and an all-inside technique with complete hamstring detachment (DHG)...
May 23, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29790372/folate-receptor-targeted-mixed-polysialic-acid-micelles-for-combating-rheumatoid-arthritis-in-vitro-and-in-vivo-evaluation
#4
Nan Zhang, Chunyu Xu, Na Li, Shasha Zhang, Lingling Fu, Xiao Chu, Haiying Hua, Xianghui Zeng, Yongxing Zhao
OBJECTIVE: Rheumatoid arthritis (RA) is associated with chronic inflammation. The suppression of inflammation is key to the treatment of RA. Glucocorticoids (GCs) are classical anti-inflammatory drugs with several disadvantages such as poor water solubility and low specificity in the body. These disadvantages are the reasons for the quick elimination and side effects of GCs in vivo. Micelles are ideal carriers for GCs delivery to inflamed synovium. We set out to improve the targeting and pharmacokinetic profiles of GCs by preparing a targeting micelle system...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29789946/outcome-of-arthroscopic-slap-repair-using-knot-tying-suture-anchors-compared-with-knotless-suture-anchors-in-athletes
#5
Y Reinig, F Welsch, R Hoffmann, D Müller, K F Schüttler, E Zimmermann, Thomas Stein
INTRODUCTION: Arthroscopic repair is one option for the surgical treatment of type II superior labrum tears from anterior to posterior (SLAP) lesions in athletes' shoulders. MATERIALS AND METHODS: Sixty-one of 78 (78.2%) athletes were retrospectively examined after isolated arthroscopic SLAP repair (group 1/G1: 28x knot-tying anchors; group 2/G2: 33 knotless anchors; follow-up 24 months) and compared to two specific, separate matched volunteer athlete control groups (group 3/G3: 28 athletes matched to G1; group 4/G4: 33 athletes matched to G2)...
May 22, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29789827/effect-of-the-monostearate-monopalmitate-ratio-on-the-oral-release-of-active-agents-from-monoacylglycerol-organogels
#6
F R Lupi, V Mancina, N Baldino, O I Parisi, L Scrivano, D Gabriele
The delivery of active agents from organogels is becoming an important topic owing to the possibility of releasing, in a controlled way, lipophilic agents. Controlled release from foods is a topic with increasing relevance owing to the growing industrial interest towards functional or medical foods, i.e. foods containing nutraceutical agents or drugs. Anyway, release properties are related to the rheological properties of organogels, and, therefore, a deep knowledge of their microstructure and physical characteristics is necessary to design carriers with expected release properties...
May 23, 2018: Food & Function
https://www.readbyqxmd.com/read/29789809/development-of-step-count-cut-points-for-school-day-vigorous-physical-activity
#7
Ryan D Burns, Timothy A Brusseau, You Fu, Peng Zhang
Background: No study has established step-count cut points for varying amounts of accelerometer-assessed vigorous physical activity (VPA) accrued during the school day in children. The purpose of this study was to establish step-count cut points for discriminating children meeting VPA in 5 minutes, 10 minutes, 15 minutes, and 20 minutes per 7-hour school day. Methods: Participants were a convenience sample of 1,053 children (mean age = 8.4 (1.8) years) recruited from 5 schools from the Mountain West region of the USA...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789419/detection-of-bladder-cancer-via-microfluidic-immunoassay-and-single-cell-dna-copy-number-alteration-analysis-of-captured-urinary-exfoliated-tumor-cells
#8
Anqi Chen, Guanghou Fu, Zhijie Xu, Yukun Sun, Xiaoyi Chen, Kok Suen Cheng, Kuang Hong Neoh, Zhewen Tang, Shifu Chen, Ming Liu, Tanxiao Huang, Yun Dai, Qibo Wang, Jing Jin, Baiye Jin, Ray P S Han
The increasing incidence of bladder cancer (BC) and its high rate of recurrence over a 5-year period necessitate the need for diagnosis and surveillance amelioration. Cystoscopy and urinary cytology are the current tools, and molecular techniques such as BTA stat, NMP22, survivin mRNA, and urovysion FISH have attracted attention, however, they suf-fer from insufficient sensitivity or specificity. We developed a novel microfluidic approach for harvesting intact urinary-exfoliated tumor cells (UETCs), either individually or in clus-ters, in a clean and segregated environment, which is crucial to minimize cross-contamination and misreads...
May 22, 2018: Cancer Research
https://www.readbyqxmd.com/read/29788791/nicotine-metabolite-ratio-and-smoking-outcomes-using-nicotine-replacement-therapy-and-varenicline-among-smokers-with-and-without-psychiatric-illness
#9
Matthew Clyde, Andrew Pipe, Charl Els, Robert Reid, Angel Fu, Alexa Clark, Heather Tulloch
INTRODUCTION: It has been suggested that the effectiveness of nicotine replacement smoking cessation pharmacotherapy may be enhanced by assessing rates of nicotine metabolism using the nicotine metabolite ratio - which reflects differences in the activity of the CYP2A6 hepatic enzyme - and titrating doses appropriately. To date, supporting evidence is equivocal, with little information regarding the assessment and effectiveness of the nicotine metabolite ratio among smokers with psychiatric conditions...
May 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29786099/cluster-to-cluster-transformation-among-au-6-au-8-and-au-11-nanoclusters
#10
Xiuqing Ren, Junhong Fu, Xinzhang Lin, Xuemei Fu, Jinghui Yan, Ren'an Wu, Chao Liu, Jiahui Huang
We present the cluster-to-cluster transformations among three gold nanoclusters, [Au6(dppp)4]2+ (Au6), [Au8(dppp)4Cl2]2+ (Au8) and [Au11(dppp)5]3+ (Au11). The conversion process follows a rule that states that the transformation of a small cluster to a large cluster is achieved through an oxidation process with an oxidizing agent (H2O2) or with heating, while the conversion of a large cluster to a small one occurs through a reduction process with a reducing agent (NaBH4). All the reactions were monitored using UV-Vis spectroscopy and ESI-MS...
May 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29785124/upregulation-of-circ_0066444-promotes-the-proliferation-invasion-and-migration-of-gastric-cancer-cells
#11
Dawei Rong, Chaoxi Dong, Kai Fu, Hanjin Wang, Weiwei Tang, Hongyong Cao
Background: Circular RNAs (circRNAs), which have closed-loop structure, are involved in the pathogenesis of human diseases including various types of carcinomas. The present study aimed to investigate the relationship between a new circular RNA named circ_0066444 and gastric cancer (GC) carcinogenesis. Materials and methods: The circ_0066444 levels in 106 paired gastric carcinoma tissues and related adjacent normal tissues were detected by real-time quantitative reverse-transcription polymerase chain reaction...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29785036/a-novel-microrna-signature-predicts-survival-in-liver-hepatocellular-carcinoma-after-hepatectomy
#12
Qiang Fu, Fan Yang, Tengxiao Xiang, Guoli Huai, Xingxing Yang, Liang Wei, Hongji Yang, Shaoping Deng
Liver hepatocellular carcinoma (LIHC) is the most common type of primary liver cancer. In the current study, genome-wide miRNA-Seq and mRNA profiles in 318 LIHC patients derived from The Cancer Genome Atlas (TCGA) were analysed to identify miRNA-based signatures for LIHC prognosis with survival analysis and a semi-supervised principal components (SPC) method. A seven-miRNA signature was confirmed for overall survival (OS) prediction by comparing miRNA profiles in paired primary tumour and solid tumour normal tissues...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784666/nomogram-integrating-genomics-with-clinicopathological-features-improves-prognosis-prediction-for-colorectal-cancer
#13
Yongfu Xiong, Wenxian You, Min Hou, Linglong Peng, He Zhou, Zhongxue Fu
The current tumor staging system is insufficient for predicting the outcomes of patients with colorectal cancer (CRC) because of its phenotypic and genomic heterogeneity. Integrating gene expression signatures with clinicopathological factors may yield a predictive accuracy exceeding that of the currently available system. Twenty-seven signatures that used gene expression data to predict CRC prognosis were identified and re-analyzed using bioinformatic methods. Next, clinically annotated CRC samples (n=1710) with the corresponding expression profiles, that predicted a patient's probability of cancer recurrence, were pooled to evaluate their prognostic values and establish a clinicopathologic-genomic nomogram...
May 21, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29784506/predicting-prognosis-in-resected-esophageal-squamous-cell-carcinoma-using-a-clinical-nomogram-and-recursive-partitioning-analysis
#14
Yuzhen Zheng, Shenshen Fu, Tiancheng He, Qihang Yan, Wenyu Di, Junye Wang
BACKGROUND: Development demand of precise medicine in resectable esophageal squamous cell carcinoma (ESCC) require to recognize patients at high risk treated by surgery alone. Thus, our aim was to construct a clinical nomogram and recursive partitioning analysis (RPA) to predict long-term survival in ESCC treated by surgery alone. METHODS: Based on the patients with ESCC who treated by three-incisional esophagectomy and two-field lymphadenectomy alone, we identified and integrated significant prognostic factors for survival to build a nomogram...
April 24, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29784450/physician-assessed-and-patient-reported-urinary-morbidity-after-radio-chemotherapy-and-image-guided-adaptive-brachytherapy-for-locally-advanced-cervical-cancer
#15
Lars Fokdal, Richard Pötter, Kathrin Kirchheiner, Jacob Chr Lindegaard, Nina Boje Kibsgaard Jensen, Christian Kirisits, Cyrus Chargari, Umesh Mahantshetty, Ina Maria Jürgenliemk-Schulz, Barbara Segedin, Peter Hoskin, Kari Tanderup
BACKGROUND AND PURPOSE: The EMBRACE study is a prospective multi-institutional study on MRI guided adaptive brachytherapy (IGABT) in locally advanced cervix cancer (LACC). This analysis describes early to late urinary morbidity assessed by physicians and patients (PRO). MATERIAL AND METHODS: A total of 1176 patients were analysed. Median follow up (FU) was 27 (1-83) months. Morbidity (CTCAE v.3) and PRO (EORTC QLQ-C30&CX24) was prospectively assessed at baseline (BL), and during FU...
May 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29783268/lipidomic-components-alterations-of-human-follicular-fluid-reveal-the-relevance-of-improving-clinical-outcomes-in-women-using-progestin-primed-ovarian-stimulation-compared-to-short-term-protocol
#16
Xiaowei Wen, Yanping Kuang, Lixia Zhou, Baofeng Yu, Qiuju Chen, Yonglun Fu, Zheng Yan, Haiyan Guo, Qifeng Lyu, Jun Xie, Weiran Chai
BACKGROUND Increasing the success rate of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is a duty of clinicians that has made many seek a variety of protocols. This study was undertaken to use a liquid chromatography-mass spectrometry (LC-MS) to define the alterations of follicular fluid (FF) lipid metabolites in patients undergoing progestin-primed ovarian stimulation (PPOS) compared with short-term protocol, revealing potential correlations between the differentially expressed lipids and ameliorative clinical outcomes...
May 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29783173/development-and-validation-of-an-analytical-method-for-regorafenib-and-its-metabolites-in-mouse-plasma
#17
Qiang Fu, Mingqing Chen, Shuiying Hu, Craig A McElroy, Ron H Mathijssen, Alex Sparreboom, Sharyn D Baker
An analytical method was developed for measuring the effect of OATP1B2 deficiency on plasma levels of the kinase inhibitor regorafenib and its metabolites regorafenib-N-oxide, N-desmethyl-regorafenib-N-oxide, and regorafenib-N-β-glucuronide (RG) in mice. Compounds were separated by liquid chromatography and monitored by a triple quadrupole mass spectrometer in the selected reaction monitoring mode after positive electrospray ionization. All calibration curves were linear in the selected concentration range (R2  ≥ 0...
May 5, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29782192/the-histone-deacetylase-inhibitor-ci994-improves-nuclear-reprogramming-and-in-vitro-developmental-potential-of-cloned-pig-embryos
#18
Long Jin, Qing Guo, Guang-Lei Zhang, Xiao-Xu Xing, Mei-Fu Xuan, Qi-Rong Luo, Zhao-Bo Luo, Jun-Xia Wang, Xi-Jun Yin, Jin-Dan Kang
Epigenetic reprogramming and somatic cell nuclear transfer (SCNT) cloning efficiency were recently enhanced using histone deacetylase inhibitors (HDACis). In this study, we investigated the time effect of CI994, an HDACi, on the blastocyst formation rate, acetylation levels of H3K9 and H4K12, DNA methylation levels of anti-5-methylcytosine (5mC), and some mRNA expression of pluripotency-related genes in pig SCNT embryos. Treatment with 10 μM CI994 for 24 hours significantly improved the blastocyst formation rate of SCNT embryos in comparison with the untreated group (p < 0...
May 21, 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29781141/resveratrol-relieves-particulate-matter-mean-diameter-2-5-%C3%AE-m-induced-oxidative-injury-of-lung-cells-through-attenuation-of-autophagy-deregulation
#19
Yuan Li, Weiwei Qian, Dengdian Wang, Yu Meng, Xiaoqian Wang, Yue Chen, Xiaoting Li, Chunfeng Xie, Caiyun Zhong, Suming Fu
Oxidative stress and inflammation are critically implicated in ambient fine particulate matter (mean diameter < 2.5 μm; PM2.5 )-induced lung injury. Autophagy, playing a crucial role in various physiopathological conditions, modulates cellular homeostasis and stress adaptation. Resveratrol is a phytoalexin that exerts potent antioxidant effects on cardiopulmonary diseases. To date, the mechanisms by which resveratrol protects against PM2.5 remain to be elucidated. In the present study, we investigated the effect of resveratrol on PM2...
May 20, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29781107/pristimerin-targeting-nf-%C3%AE%C2%BAb-pathway-inhibits-proliferation-migration-and-invasion-in-esophageal-squamous-cell-carcinoma-cells
#20
Yuanqing Tu, Fuxing Tan, Jingfeng Zhou, Jingxuan Pan
Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer-related death with poor prognosis in China. Identifying novel targeted therapies in ESCC is urgently needed. The aberrant activation of NF-κB signalling pathway is critical for prognosis and recurrence of ESCC, which make it a potential target in the treatment of ESCC. Here, we found that pristimerin inhibited ESCC cell proliferation, migration, invasion, induced cell apoptosis, and eliminated cancer stem-like cells (CSCs). It also showed a synergistic effect on ESCC when combined with 5-fluorouracil (5-FU)...
May 20, 2018: Cell Biochemistry and Function
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