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https://www.readbyqxmd.com/read/29161604/ecological-effects-and-potential-risks-of-the-water-diversion-project-in-the-heihe-river-basin
#1
Mengmeng Zhang, Shuai Wang, Bojie Fu, Guangyao Gao, Qin Shen
To curb the severe ecological deterioration in the lower Heihe River Basin (HRB) in northwest China, a water diversion project was initiated in 2000. A comprehensive analysis of the ecological effects and potential risks associated with the project is needed. We assessed the hydrological and ecological achievements, and also analyzed the potential problems after the project was completed. We found that since the project began the hydrological regime has changed, with more than 57.82% of the upstream water being discharged to the lower reaches on average...
November 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29160958/prognostic-value-of-an-immunohistochemical-signature-in-patients-with-esophageal-squamous-cell-carcinoma-undergoing-radical-esophagectomy
#2
Jin Meng, Junhua Zhang, Yingjie Xiu, Yan Jin, Jiaqing Xiang, Yongzhan Nie, Shen Fu, Kuaile Zhao
Here, we aimed to identify an immunohistochemical (IHC)-based classifier as a prognostic factor in patients with esophageal squamous cell carcinoma (ESCC). A cohort of 235 patients with ESCC undergoing radical esophagectomy (with complete clinical and pathological information) were enrolled in the study. Using the least absolute shrinkage and selection operator (LASSO) regression model, we extracted six IHC features associated with progression-free survival (PFS) and then built a classifier in the discovery cohort (n=141)...
November 21, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29160695/fabrication-of-new-uranyl-phosphonates-by-varying-quaternary-ammonium-cation-synthesis-structure-luminescent-properties-and-single-crystal-to-single-crystal-transformation
#3
Si-Fu Tang, Xiaomin Hou, Dandan Liu, Xuebo Zhao
Four new uranyl triphosphonates, namely, [N(CH4)4][UO2(H3L)][H2O] (1), [(UO2)1.5(H3L)(H2O)1.5][H2O] (2), [NBu4][(UO2)3.5(H2L)2][(H2O)4.5] (3), and [(UO2)1.5(H3L)(H2O)2.5][(H2O)2.5] (4), where H6L = benzene-1,3,5-triyltris(methylene)triphosphonic acid, were obtained from a triphosphonate ligand in the presence of different quaternary ammonium cations. The structural characterization revealed that the introduction of quaternary ammonium cation had a major impact on the structure formation of uranyl phosphonates...
November 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29159766/incidence-of-immune-related-adverse-events-and-its-association-with-treatment-outcomes-the-md-anderson-cancer-center-experience
#4
Takeo Fujii, Rivka R Colen, Mehmet Asim Bilen, Kenneth R Hess, Joud Hajjar, Maria E Suarez-Almazor, Anas Alshawa, David S Hong, Apostolia Tsimberidou, Filip Janku, Jing Gong, Bettzy Stephen, Vivek Subbiah, Sarina A Piha-Paul, Siqing Fu, Padmanee Sharma, Tito Mendoza, Anisha Patel, Selvi Thirumurthi, Ajay Sheshadri, Funda Meric-Bernstam, Aung Naing
Background Immunotherapy is emerging as the cornerstone for treatment of patients with advanced cancer, but significant toxicity (immune-related adverse events [irAEs]) associated with unbridled T cell activity remains a concern. Patients and methods A retrospective review of the electronic medical records of 290 patients with advanced cancer treated on an immunotherapy-based clinical trial in the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center between February 2010 and September 2015 was performed...
November 21, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29158972/short-term-effects-of-co2-leakage-on-the-soil-bacterial-community-in-a-simulated-gas-leakage-scenario
#5
Jing Ma, Wangyuan Zhang, Shaoliang Zhang, Qianlin Zhu, Qiyan Feng, Fu Chen
The technology of carbon dioxide (CO2) capture and storage (CCS) has provided a new option for mitigating global anthropogenic emissions with unique advantages. However, the potential risk of gas leakage from CO2 sequestration and utilization processes has attracted considerable attention. Moreover, leakage might threaten soil ecosystems and thus cannot be ignored. In this study, a simulation experiment of leakage from CO2 geological storage was designed to investigate the short-term effects of different CO2 leakage concentration (from 400 g m(-2) day(-1) to 2,000 g m(-2) day(-1)) on soil bacterial communities...
2017: PeerJ
https://www.readbyqxmd.com/read/29158969/5-fluorouracil-and-irinotecan-sn-38-have-limited-impact-on-colon-microbial-functionality-and-composition-in-vitro
#6
Eline Vanlancker, Barbara Vanhoecke, Andrea Stringer, Tom Van de Wiele
Gastrointestinal mucositis is a debilitating side effect of chemotherapy treatment, with currently no treatment available. As changes in microbial composition have been reported upon chemotherapy treatment in vivo, it is thought that gut microbiota dysbiosis contribute to the mucositis etiology. Yet it is not known whether chemotherapeutics directly cause microbial dysbiosis, thereby increasing mucositis risk, or whether the chemotherapeutic subjected host environment disturbs the microbiome thereby aggravating the disease...
2017: PeerJ
https://www.readbyqxmd.com/read/29158491/gallstone-disease-and-the-risk-of-type-2-diabetes
#7
Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Shanpeng Li, Yuelong Huang, Yan Fu, Pan He, Aiyu Tang, Junshi Chen, Zhengming Chen, Lu Qi, Liming Li
Gallstone disease (GSD) is related to several diabetes risk factors. The present study was to examine whether GSD was independently associated with type 2 diabetes in the China Kadoorie Biobank study. After excluding participants with prevalent diabetes and prior histories of cancer, heart disease, and stroke at baseline, 189,154 men and 272,059 women aged 30-79 years were eligible for analysis. The baseline prevalence of GSD was 5.7% of the included participants. During 4,138,687 person-years of follow-up (median, 9...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158131/development-of-a-low-cost-paper-based-elisa-method-for-rapid-escherichia-coli-o157-h7-detection
#8
REVIEW
Bo Pang, Chao Zhao, Li Li, Xiuling Song, Kun Xu, Juan Wang, Yushen Liu, Kaiyue Fu, Hao Bao, Dandan Song, Xiangjun Meng, Xiaofeng Qu, Zhuping Zhang, Juan Li
Escherichia coli O157: H7 (E. coli O157: H7) has become one of the most dangerous foodborne pathogenic bacteria around the world. Currently, because of the tedious, high-cost and stringent laboratory conditions required, the conventional E. coli O157: H7 detection methods, such as culture-based methods and polymerase chain reaction (PCR), have much limitation. Thus, we developed a novel paper-based enzyme-linked immunosorbent assay (p-ELISA) with shorter operation duration, lower cost, relatively higher sensitivity and wider application...
November 17, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29157825/1-6-di-o-caffeoyl-%C3%AE-d-glucopyranoside-a-natural-compound-from-callicarpa-nudiflora-hook-impairs-p2y12-and-thromboxane-a2-receptor-mediated-amplification-of-platelet-activation-and-aggregation
#9
Jianjiang Fu, Xiaocui Zhu, Wei Wang, Hong Lu, Zhoumiao Zhang, Ting Liu, Huanjun Xu, Huizheng Fu, Shuangcheng Ma, Yuehua Luo
BACKGROUND: Platelet activation and subsequent accumulation at sites of vascular injury perform a central role in thrombus formation, which is believed to be the trigger of several cardiovascular diseases, such as atherosclerosis, myocardial infarction and strokes. In this sense, the search for agents that are capable of blocking platelets aggregation has important implications for these diseases. Callicarpa nudiflora (C. nudiflora) Hook is a traditional Chinese medicine herb for eliminating stasis to subdue swelling and hemostasis...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29157231/risk-factors-for-contralateral-inguinal-hernia-repair-after-unilateral-inguinal-hernia-repair-in-male-adult-patients-analysis-from-a-nationwide-population-based-cohort-study
#10
Cheng-Hung Lee, Yu-Ting Chiu, Chi-Fu Cheng, Jin-Chia Wu, Wen-Yao Yin, Jian-Han Chen
BACKGROUND: To identify the rate of and risk factors for contralateral inguinal hernia (CIH) after unilateral inguinal hernia repair in adult male patients. METHODS: This retrospective cohort study identified from the Taiwan National Health Insurance Research Database (NHIRD). Information on all adult patients who underwent primary unilateral inguinal hernia repair without any other operation was collected using ICD-9 diagnostic and procedure codes. The exclusion criteria were laparoscopic hernia repair, non-primary repair, complicated hernia, other combined procedures, female and undetermined gender...
November 21, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29156986/microbial-transformation-of-resveratrol-by-endophyte-streptomyces-sp-a12-isolated-from-polygonum-cuspidatum
#11
Tian Jiewei, Wang Lei, Long Xiufeng, Zhang Heming, Li Xiaoguang, Fu Haiyan, Tian Yongqiang
Resveratrol (1) undergoes microbial transformation when fermented with Streptomyces sp. A12 to yield 3, 5, 4'-trimethoxy-trans-stilbene (2). The structure of the compound 2 was elucidated using the modern spectroscopic techniques. This is the first report of the microbial transformation of resveratrol to compound 2 using the endophyte isolated from Polygonum cuspidatum.
November 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29156843/clinical-efficacy-of-neoadjuvant-chemotherapy-regimens-fleeox-vs-xelox-in-patients-with-initially-unresectable-advanced-gastric-cancer-a-propensity-score-analysis
#12
Yang Li, Jun Chen, Qi He, Xiang Ji, Xulin Wang, Chaogang Fan, Guoli Li
Purpose: This study was designed to assess the effectiveness of FLEEOX (5-Fu, leucovorin, etoposide, oxaliplatin, and epirubicin) compared with XELOX (capecitabine and oxaliplatin) as neoadjuvant chemotherapy (NAC) for initially unresectable advanced gastric cancer (AGC). Methods: This study reviewed patients who underwent FLEEOX or XELOX for initially unresectable AGC. To reduce the bias in patient selection, we conducted propensity score match (PSM) with 1:1 ratio...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156835/indonesian-herbal-medicine-prevents-hypertension-induced-left-ventricular-hypertrophy-by-diminishing-nadph-oxidase-dependent-oxidative-stress
#13
Erna Sulistyowati, Jong-Hau Hsu, Yuan-Bin Cheng, Fang-Rong Chang, Ying-Fu Chen, Jwu-Lai Yeh
Indonesian herbal medicine Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction (CJID) are known to be efficacious for hypertension. Oxidative stress plays an important role in hypertension-induced left ventricular hypertrophy (H-LVH). This study evaluated whether CJID inhibit cardiac remodeling in spontaneously hypertensive rats (SHRs) through mechanism of oxidative stress-related cardiac-NADPH oxidase (NOXs) pathway: NOX1, NOX2 and NOX4. Forty-weeks-old SHRs and normotensive-WKY rats, were both randomly divided into 2 groups: CJID and control...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156744/changes-of-alpha-fetoprotein-levels-could-predict-recurrent-hepatocellular-carcinoma-survival-after-trans-arterial-chemoembolization
#14
Chao He, Xiaoyun Zhang, Chuan Li, Wei Peng, Tian-Fu Wen, Lv-Nan Yan, Jiayin Yang, Wusheng Lu
Background: There is paucity of information concerning whether AFP change is a predictor of prognosis for recurrent hepatocellular carcinoma (RHCC) patients after trans-arterial chemoembolization (TACE). Methods: A total of 177 RHCC patients who received TACE as first-line therapy were retrospectively analyzed. The patients were classified into three groups according to their pre-TACE and post-TACE AFP levels (group A: AFP decreased, group B: AFP consistent normal, and group C: AFP increased)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156733/an-integrated-lncrna-microrna-and-mrna-signature-to-improve-prognosis-prediction-of-colorectal-cancer
#15
Yongfu Xiong, Rong Wang, Linglong Peng, Wenxian You, Jinlai Wei, Shouru Zhang, Xingye Wu, Jinbao Guo, Jun Xu, Zhenbing Lv, Zhongxue Fu
Although the outcome of patients with colorectal cancer (CRC) has improved significantly, prognosis evaluation still presents challenges due to the disease heterogeneity. Increasing evidences revealed the close correlation between aberrant expression of certain RNAs and the prognosis. We envisioned that combined multiple types of RNAs into a single classifier could improve postoperative risk classification and add prognostic value to the current stage system. Firstly, differentially expressed RNAs including mRNAs, miRNAs and lncRNAs were identified by two different algorithms...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156524/kif3a-knockdown-sensitizes-bronchial-epithelia-to-apoptosis-and-aggravates-airway-inflammation-in-asthma
#16
Gang Geng, Ying Du, Jihong Dai, Daiyin Tian, Yunqiu Xia, Zhou Fu
BACKGROUND: KIF3A expression was decreased in asthmatic child patients and animal. Impaired KIF3A expression resulted in increased Th2 inflammation in mice and apoptosis in renal tubular epithelium and photoreceptor cells. This work aimed to investigate the role of KIF3A in epithelium apoptosis and bronchial inflammation in asthma. METHODS: After establishment of ovalbumin induced asthma, the mice were infected with KIF3A adenovirus through nasal cavity inhalation...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156330/hospital-and-demographic-characteristics-associated-with-inpatient-neurological-services-in-the-united-states
#17
Katherine A Fu, Ali Razmara, Steven Y Cen, Amytis Towfighi, William J Mack, Nerses Sanossian
OBJECTIVE: To determine nationwide availability and factors associated with inpatient neurological services. PATIENTS AND METHODS: Using the 2011 American Hospital Association survey, we determined the proportion of hospitals that provided inpatient neurological services. Demographic and household data from the 2010 national census and survey results were utilized to determine regional factors associated with the availability of inpatient neurologic services. Using rate ratios, the association was estimated using Poisson regression...
November 7, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29155481/peroxisome-proliferator-activated-receptor-gamma-stimulation-for-prevention-of-5-fluorouracil-induced-oral-mucositis-in-mice
#18
Mariangela Sottili, Monica Mangoni, Chiara Gerini, Giulia Salvatore, Francesca Castiglione, Isacco Desideri, Pierluigi Bonomo, Icro Meattini, Daniela Greto, Mauro Loi, Giulio Francolini, Marco Perna, Roberta Grassi, Giampaolo Biti, Lorenzo Livi
BACKGROUND: Oral mucositis is a side effect of treatment regimens containing 5-fluorouracil (5-FU). The purpose of this study was to present our evaluation to see if rosiglitazone (RGZ) protected normal tissues from chemotherapy-induced oral mucositis. METHODS: C57BL/6J mice were treated with 5-FU for 5 days, with or without RGZ. Mice were euthanized after 5, 8, 11, or 15 days, and mucosal segments were collected. RESULTS: The RGZ did not affect the 5-FU-induced decrease in mouse body weight...
November 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/29155397/facile-phyto-mediated-synthesis-of-silver-nanoparticles-using-chinese-winter-jujube-ziziphus-jujuba-mill-cv-dongzao-extract-and-their-antibacterial-catalytic-properties
#19
Chun-Gang Yuan, Can Huo, Bing Gui, Jing-Fu Liu, Yong-Sheng Chen
The aqueous extract of Chinese winter jujube (Ziziphus jujuba Mill. cv. Dongzao) was used as reducing and capping agents for the synthesis of silver nanoparticles (AgNPs) for the first time. The resulting AgNPs were characterised by UV/Visible (UV-Vis) spectroscopy, atomic force microscope, transmission electron microscopy, selected area electron diffraction, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray and Fourier transform infrared spectroscopy (FTIR). The colloidal solution of AgNPs gave a maximum UV-Vis absorbance at 446 nm...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29153096/correlations-between-microsatellite-instability-ercc1-xrcc1-polymorphism-and-clinical-characteristics-and-folfox-adjuvant-chemotherapy-effect-of-colorectal-cancer-patients
#20
Liping Zhang, Jiangman Zhao, Bin Yu, Xinjiang Song, Guogang Sun, Lijiang Han, Lu Wang, Shu Dong
Patients with MSI colorectal tumor have good prognosis and cannot benefit from 5-fluorouracil (5-Fu)-based chemotherapy reported by previous studies. While, single nucleotide polymorphisms (SNP) of ERCC1 and XRCC1 have be proved to influence clinical outcome of colorectal cancer patients treated with oxaliplatin-based chemotherapy. We aim to study the correlation between molecular status and clinical- pathological features, and their effect on CRC patients' clinical outcome treated with mFOLFOX6 adjuvant chemotherapy...
December 2017: Cancer Genetics
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