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Wound Repair

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https://www.readbyqxmd.com/read/29775721/critical-evaluation-of-2-ethylhexyl-acrylate-dermal-carcinogenicity-studies-using-contemporary-criteria
#1
REVIEW
Sandra Murphy, Robert Ellis-Hutchings, Lavorgie Finch, Stefanie Welz, Karin Wiench
Skin tumors have been observed in C3H/HeJ mice following treatment with high and strongly irritating concentrations of 2-ethylhexyl acrylate (2-EHA). Dermal carcinogenicity studies performed with 2-EHA are reviewed, contrasting the results in two mouse strains (C3H/HeJ and NMRI) under different dosing regimens. Application of contemporary evaluation criteria to the existing dermal carcinogenicity dataset demonstrates that 2-EHA induces skin tumors only at concentrations exceeding an maximum tolerated dose (MTD) and in the immune-dysregulated C3H/HeJ mouse model...
May 15, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29775632/controlled-delivery-of-a-focal-adhesion-kinase-inhibitor-results-in-accelerated-wound-closure-with-decreased-scar-formation
#2
Kun Ma, Sun Hyung Kwon, Jagannath Padmanabhan, Dominik Duscher, Artem A Trotsyuk, Yixiao Dong, Mohammed Inayathullah, Jayakumar Rajadas, Geoffrey C Gurtner
Formation of scars following wounding or trauma represents a significant healthcare burden costing the economy billions of dollars every year. Activation of focal adhesion kinase (FAK) has been shown to play a pivotal role in transducing mechanical signals to elicit fibrotic responses and scar formation during wound repair. We have previously shown that inhibition of FAK using local injections of a small molecule FAK inhibitor (FAKI) can attenuate scar development in a hypertrophic scar model. Clinical translation of FAKI therapy has been challenging, however, due to the lack of an effective drug delivery system for extensive burn injuries, blast injuries, and large excisional injuries...
May 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29774540/conservative-thickness-layers-in-mohs-micrographic-surgery
#3
Stanislav N Tolkachjov, Jonathan A Cappel, Elizabeth A Bryant, Christopher B Harmon
BACKGROUND: Mohs micrographic surgery (MMS) is used to treat cutaneous malignancies in locations to maximize tissue sparing. The authors' aim is to demonstrate the utility of conservative thickness layers (CTL) in MMS and review patient and tumor characteristics and the potential anatomic locations where this technique may be most useful. METHODS: We performed a retrospective chart review of patients with tumors treated with CTL in MMS of 339 tumors, recording patient demographics, tumor characteristics, MMS stages for clearance, repairs, complications, and follow-up...
May 17, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29772391/development-of-ionic-liquid-assisted-synthesized-nano%C3%A2-silver-combined-with-vascular-endothelial-growth-factor-as-wound-healing-in-the-care-of-femoral-fracture-in-the-children-after-surgery
#4
Xingli Li, Maohua Liu, Hongxia Cheng, Qun Wang, Chuanna Miao, Shumei Ju, Fang Liu
This investigation aimed to develop the silver (Ag) nanoparticles incorporated vascular endothelial growth factor (VEGF) for the improvement wound healing and reduce Aseptic necrosis in treatment of femoral fracture healing. The spherical shaped Ag nanoparticles with improved morphology have been effectively synthesized via microwave assisted method using ionic liquids 1-dodecyl-3-methylimidazolium chloride. The morphological structure and crystalline properties of Ag nanoparticles are analyzed by using UV, XRD and TEM-EDX analytical methods...
March 6, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29772339/wound-healing-effects-of-a-curcuma-zedoaria-polysaccharide-with-platelet-rich-plasma-exosomes-assembled-on-chitosan-silk-hydrogel-sponge-in-a-diabetic-rat-model
#5
Ning Xu, Lili Wang, Junjie Guan, Chao Tang, Ning He, Wei Zhang, Shiping Fu
One homogeneous polysaccharide (ZWP) was successfully isolated and purified from the rhizomes of Curcuma zedoaria and the aim of present study was to determine the potential of chitosan/silk hydrogel sponge loaded with platelet-rich plasma exosomes (PRP-Exos), ZWP or PRP-Exos/ZWP on wound-healing in diabetic rats. An in vivo diabetic wound healing study showed that separate or combined treatments all resulted in a wound contraction in diabetic rats, as evidenced by a decrease of ulcer and an increase of epidermal thickness, but PRP-Exos/ZWP combination therapy was more successful in wound closing than either PRP-Exos or ZWP single administration...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29770194/clinical-utility-of-hyperbaric-oxygen-therapy-in-genitourinary-medicine
#6
REVIEW
Jason Gandhi, Omar Seyam, Noel L Smith, Gunjan Joshi, Sohrab Vatsia, Sardar Ali Khan
Hyperbaric oxygen therapy (HBOT) is a medical technique which delivers oxygen at ambient pressures to increase the amount of dissolved oxygen in the blood and oxygen distribution to tissues. There are several beneficial properties of HBOT concomitant with elevated oxygen distribution in tissue including anti-inflammation, angiogenesis through vascular endothelial growth factor proliferation, augmented fibroblast activity through fibroblast growth factor proliferation, tissue and wound repair, enhancement of lymphocyte and macrophage activity, increased male testosterone secretion, and bactericidal activity...
January 2018: Medical Gas Research
https://www.readbyqxmd.com/read/29766783/role-of-formyl-peptide-receptors-in-gastrointestinal-healing
#7
Nella Prevete, Amato De Paulis, Dolores Sgambato, Rosa Marina Melillo, Giuseppe D'Argenio, Lorenzo Romano, Rocco Maurizio Zagari, Marco Romano
The wound healing and the barrier restoration of the gastrointestinal (GI) mucosa must be continuously ensured to allow homeostasis of the gastrointestinal tract and of all the surrounding tissues. Several lines of the evidence report a key role of innate immunity, and in particular of Pattern Recognition Receptors (PRRs), in controlling the homeostasis of GI tract by sensing commensal and pathogen bacteria, activating the immune response and regulating epithelial repair, thus guaranteeing the morphological and functional recovery of the injured tissue...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29764244/kinetics-and-tissue-repair-process-following-fractional-bipolar-radiofrequency-treatment
#8
G Kokolakis, L von Eichel, M Ulrich, J Lademann, T Zuberbier, M A Hofmann
INTRODUCTION: Fractionated radiofrequency (RF) tissue tightening is an alternative method to fractionated laser treatment of skin wrinkling, laxity and acne scars, with reduced risk of scarring or persistent pigmentation. The aim of this study was to evaluate and quantify the wound healing process after RF treatment. MATERIALS AND METHODS: 12 patients were treated with a 64-pin fractional bipolar RF device with 60 mJ/pin applied energy. Confocal laser scanning microscopy (CLSM) examination was performed on day 1, day 2, day 7 and day 14 after treatment...
May 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29763436/treatment-of-limb-wounds-of-horses-with-orf-virus-il-10-and-vegf-e-accelerates-resolution-of-exuberant-granulation-tissue-but-does-not-prevent-its-development
#9
Lyn M Wise, Christa J Bodaan, Gabriella S Stuart, Nicola C Real, Zabeen Lateef, Andrew A Mercer, Christopher B Riley, Christine L Theoret
Bandaging of limb wounds in horses leads to formation of exuberant granulation tissue (EGT) that retards healing due to protracted inflammation, aberrant vascularisation and delayed epithelialisation. EGT is not observed if wounds are left undressed or when wounds are on the body. A previous study showed that short-term administration of proteins derived from orf virus dampened inflammation and promoted epithelialisation of open wounds in horses. Here, we investigated the impact of orf virus interleukin-10 and vascular endothelial growth factor-E on the development and resolution of EGT...
2018: PloS One
https://www.readbyqxmd.com/read/29761584/reduction-of-fibrosis-and-scar-formation-by-partial-reprogramming-in-vivo
#10
Markus C Doeser, Hans R Schöler, Guangming Wu
Transient expression of the transcription factors OCT4, SOX2, KLF4 and C-MYC (OSKM) to induce partial reprogramming while avoiding the pluripotent state and teratoma formation has recently been discussed as a strategy for regenerating damaged tissues in vivo, whereby the impact of partial reprogramming on tissue repair remains to be elucidated. Here, we activated OSKM transcription factors in cutaneous wounds of OSKM-inducible transgenic mice and found that induction of OSKM factors in excisional wounds caused a diminished fibroblast transdifferentiation to myofibroblasts and wound contraction...
May 15, 2018: Stem Cells
https://www.readbyqxmd.com/read/29761573/using-fat-to-fight-disease-a-systematic-review-of-non-homologous-adipose-derived-stromal-stem-cell-therapies
#11
REVIEW
Marjorie E Bateman, Amy L Strong, Jeffrey M Gimble, Bruce A Bunnell
OBJECTIVE: The objective of this review is to describe the safety and efficacy of ASC and SVF in treating common diseases and the next steps in research that must occur prior to clinical use. EVIDENCE REVIEW: Pubmed, Ovid Medline, Embase, Web of Science, and the Cochrane Library were searched for articles about use of SVF or ASC for disease therapy published between 2012 and 2017. One meta-analysis, 2 randomized controlled trials, and 16 case series were included, representing 844 human patients...
May 15, 2018: Stem Cells
https://www.readbyqxmd.com/read/29759951/immediate-and-long-term-results-of-unsintered-hydroxyapatite-and-poly-l-lactide-composite-sheets-for-orbital-wall-fracture-reconstruction
#12
Keishi Kohyama, Yoko Morishima, Koki Arisawa, Yuko Arisawa, Hisakazu Kato
INTRODUCTION: Bone defect reconstruction in orbital wall fractures with absorbable alloplastic such as the unsintered hydroxyapatite and poly L-lactide composite (u-HA/PLLA) system is gaining popularity. The u-HA/PLLA material has osteoconductive and osteosynthetic properties. However, quantitative, long-term outcome data after the use of u-HA/PLLA for orbital wall fractures are lacking. PATIENTS AND METHODS: We retrospectively analyzed 115 patients who underwent surgical repair of orbital wall fractures with a u-HA/PLLA sheet from 2011 to 2016...
March 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29759011/preservation-technique-of-the-piriformis-tendon-is-superior-to-reattachment-technique-in-terms-of-contiguity-and-muscle-atrophy-using-magnetic-resonance-imaging
#13
So Minokawa, Masatoshi Naito, Kei Shiramizu, Yoshinari Nakamura, Koichi Kinoshita, Tomohiko Minamikawa, Hajime Seo, Takuaki Yamamoto
PURPOSE: The preservation technique of the piriformis tendon during the posterolateral approach in total hip arthroplasty (THA) is reportedly superior to the reattachment technique in terms of dislocation. However, the long-term effects of preservation of the piriformis tendon during THA remain unknown. In this study, we evaluated the contiguity of the piriformis/conjoined tendon and atrophy of the piriformis/internal obturator muscle during a long-term postoperative follow-up using magnetic resonance imaging (MRI)...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29757664/reverse-saphenous-conduit-flap-in-19-dogs-and-1-cat
#14
Jacqueline V J Cavalcanti, Sabrina L Barry, Otto I Lanz, Katherine Barnes, Julia V Coutin
The purpose of this retrospective study was to report the outcomes of 19 dogs and 1 cat undergoing reverse saphenous conduit flap between 1999 and 2016. Reverse saphenous conduit flap was used to treat traumatic wounds and wounds resulting from tumor excision in the hind limb; the majority of cases had medial shearing injuries. All animals had complete flap survival. In five animals (20%), minor donor site dehiscence occurred, which did not require surgery. Other postoperative complications included signs of severe venous congestion in one dog...
May 14, 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29756100/randomized-prospective-comparison-of-long-term-results-of-onlay-and-sublay-mesh-repair-techniques-for-incisional-hernia
#15
Barış Sevinç, Ahmet Okuş, Serden Ay, Nergis Aksoy, Ömer Karahan
Objective: Incisional hernia is a significant problem after laparotomy, and there is still no consensus on an ideal treatment method. The aim of this study was to compare the results of onlay and sublay mesh repair techniques. Material and Methods: In this randomized prospective trial, 100 patients were divided into two groups: onlay and sublay groups. Recurrences were evaluated by performing a physical examination. Results: The median follow-up was 37...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29755977/wearable-technology-for-chronic-wound-monitoring-current-dressings-advancements-and-future-prospects
#16
REVIEW
Matthew S Brown, Brandon Ashley, Ahyeon Koh
Chronic non-healing wounds challenge tissue regeneration and impair infection regulation for patients afflicted with this condition. Next generation wound care technology capable of in situ physiological surveillance which can diagnose wound parameters, treat various chronic wound symptoms, and reduce infection at the wound noninvasively with the use of a closed loop therapeutic system would provide patients with an improved standard of care and an accelerated wound repair mechanism. The indicating biomarkers specific to chronic wounds include blood pressure, temperature, oxygen, pH, lactate, glucose, interleukin-6 (IL-6), and infection status...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29755852/high-frequency-generator-in-wound-healing-of-marjolin-s-ulcer-after-carcinoma-resection
#17
Pascale Mutti Tacani, Rogério Eduardo Tacani, Aline Fernanda Perez Machado, Débora Montezello, João Carlos Guedes Sampaio Góes, Angela Gonçalves Marx, Richard Eloin Liebano
Marjolin's ulcers (MU) are skin malignancies that form over burn injuries. These very aggressive ulcers can result in functional and wound healing impairment, and require a well thought out treatment plan. Physiotherapy offers resources to help promote recovery of these patients, as described in this case report, in which the patient with a history of burn in the lower limbs evolved to malignancy 32 years later. This patient underwent tumor resection of the left foot, with recurrence and lymphadenectomy . Physical therapy included the application of high-frequency generator (HFG) for wound healing and exercises for functional recovery...
May 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29755850/three-dimensional-printing-and-cell-therapy-for-wound-repair
#18
REVIEW
Sylvia van Kogelenberg, Zhilian Yue, Jeremy N Dinoro, Christopher S Baker, Gordon G Wallace
Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach to regenerative medicine, whereby cells and cell-based materials can be dispensed in fine spatial arrangements to mimic native tissue. Recent Advances: Various bioprinting techniques have been employed in wound repair-based skin tissue engineering, from laser-induced forward transfer to extrusion-based methods, and with the investigation of the benefits and shortcomings of each, with emphasis on biological compatibility and cell proliferation, migration, and vitality...
May 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29754621/incisional-hernia-repair-minimally-invasive-approaches
#19
REVIEW
Jeremy A Warren, Michael Love
A common surgical procedure, ventral hernia repair has long been a vexing problem, with no clear standard for repair and significant postoperative morbidity. Laparoscopic repair has the clear advantage of lower postoperative morbidity. However, application of laparoscopic ventral hernia repair is often limited by patient factors and hernia morphology. Long-term complications of intraperitoneal mesh and recurrence are concerning. Robotic-assisted surgery is the latest advance in minimally invasive hernia repair, combining the advantages of open repair with complete abdominal wall reconstruction and restoration of functional anatomy with the wound morbidity and decreased recovery time of laparoscopy...
June 2018: Surgical Clinics of North America
https://www.readbyqxmd.com/read/29754618/preoperative-planning-and-patient-optimization
#20
REVIEW
Clayton C Petro, Ajita S Prabhu
This article reviews the literature that supports routine expectations for smoking cessation; weight loss; diabetic, nutritional, or metabolic optimization; and decolonization techniques before ventral hernia repair. These methods diminish postoperative complications. In an era of value-centric care, an upfront investment in patient optimization can improve the quality of the repair by reducing wound morbidity and hernia recurrence, naturally translating to a reduction in cost. The adoption of these practices and further study aimed at identifying other effective optimization techniques are encouraged...
June 2018: Surgical Clinics of North America
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