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https://www.readbyqxmd.com/read/29454293/health-professions-faculty-beliefs-confidence-use-and-perceptions-of-organizational-culture-and-readiness-for-ebp-a-cross-sectional-descriptive-survey
#1
Kerry A Milner, Holly B Bradley, Tammy Lampley
BACKGROUND: Evidence-based practice (EBP) is an essential skill and ethical obligation for all practicing health professions clinicians because of its strong association with improved health outcomes. Emerging evidence suggests that faculty who prepare these clinicians lack proficiency to teach EBP. OBJECTIVES: The purpose of this study was to describe; 1) health profession faculty beliefs about and confidence in their ability to teach and implement EBP, 2) use of EBP for education, 3) organizational culture and readiness for EBP; and to determine whether relationships exist among these variables...
February 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29454256/five-month-old-infants-have-expectations-for-the-accumulation-of-nonsolid-substances
#2
Erin M Anderson, Susan J Hespos, Lance J Rips
Infants fail to represent quantities of non-cohesive substances in paradigms where they succeed with solid objects. Some investigators have interpreted these results as evidence that infants do not yet have representations for substances. More recent research, however, shows that 5-month-old infants expect objects and substances to behave and interact in different ways. In the present experiments, we test whether infants have expectations for substances when the outcomes are not simply the opposite of those for objects...
February 14, 2018: Cognition
https://www.readbyqxmd.com/read/29454244/-keeping-birth-normal-exploratory-evaluation-of-a-training-package-for-midwives-in-an-inner-city-alongside-midwifery-unit
#3
Shawn Walker, Laura Batinelli, Lucia Rocca-Ihenacho, Christine McCourt
OBJECTIVES: to gain understanding about how participants perceived the value and effectiveness of 'Keeping Birth Normal' training, barriers to implementing it in an along-side midwifery unit, and how the training might be enhanced in future iterations. DESIGN: exploratory interpretive. SETTING: inner-city maternity service. PARTICIPANTS: 31 midwives attending a one-day training package on one of three occasions. METHODS: data were collected using semi-structured observation of the training, a short feedback form (23/31 participants), and focus groups (28/31 participants)...
February 2, 2018: Midwifery
https://www.readbyqxmd.com/read/29454202/global-patterns-of-extreme-drought-induced-loss-in-land-primary-production-identifying-ecological-extremes-from-rain-use-efficiency
#4
Ling Du, Nathaniel Mikle, Zhenhua Zou, Yuanyuan Huang, Zheng Shi, Lifen Jiang, Heather R McCarthy, Junyi Liang, Yiqi Luo
Quantifying the ecological patterns of loss of ecosystem function in extreme drought is important to understand the carbon exchange between the land and atmosphere. Rain-use efficiency [RUE; gross primary production (GPP)/precipitation] acts as a typical indicator of ecosystem function. In this study, a novel method based on maximum rain-use efficiency (RUE max ) was developed to detect losses of ecosystem function globally. Three global GPP datasets from the MODIS remote sensing data (MOD17), ground upscaling FLUXNET observations (MPI-BGC), and process-based model simulations (BESS), and a global gridded precipitation product (CRU) were used to develop annual global RUE datasets for 2001-2011...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454156/the-glun2b-subunit-represents-a-major-functional-determinant-of-nmda-receptors-in-human-induced-pluripotent-stem-cell-derived-cortical-neurons
#5
Ioana Neagoe, Chang Liu, Alexander Stumpf, Yanmei Lu, Dongping He, Ross Francis, Jun Chen, Paul Reynen, Moulay Hicham Alaoui-Ismaili, Hirokazu Fukui
Abnormal signaling pathways mediated by N-methyl-d-aspartate receptors (NMDARs) have been implicated in the pathogenesis of various CNS disorders and have been long considered as promising points of therapeutic intervention. However, few efforts have been previously described concerning evaluation of therapeutic modulators of NMDARs and their downstream pathways in human neurons with endogenous expression of NMDARs. In the present study, we assessed expression, functionality, and subunit composition of endogenous NMDARs in human induced pluripotent stem cell (hiPSC)-derived cortical neurons (iCell Neurons and iCell GlutaNeurons)...
February 8, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29454135/short-term-outcomes-following-posterior-cervical-fusion-among-octogenarians-with-cervical-spondylotic-myelopathy-a-nsqip-database-analysis
#6
Caroline E Vonck, Joseph E Tanenbaum, Thomas T Bomberger, Edward C Benzel, Jason W Savage, Iain H Kalfas, Thomas E Mroz, Michael P Steinmetz
BACKGROUND: Context: Degenerative changes in the cervical spine occur in an age-dependent manner. As the U.S. population continues to age, the incidence of age-dependent, multi-level, degenerative cervical pathologies is expected to increase. Similarly, the average age of patients with cervical spondylotic myelopathy (CSM) will likely trend upward. Posterior cervical fusion (PCF) is often the treatment modality of choice in the management of multi-level cervical spine disease. Although outcomes following anterior cervical fusion for degenerative disease have been studied among older patients (aged 80 years and older), it is unknown if these results extend to octogenarian patients undergoing PCF for the surgical management of CSM...
February 14, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29454134/back-pain-improves-significantly-following-discectomy-for-lumbar-disc-herniation
#7
R Kirk Owens, Leah Y Carreon, Erica F Bisson, Mohamad Bydon, Eric A Potts, Steven D Glassman
BACKGROUND CONTEXT: Although lumbar disc herniation (LDH) classically presents with lower extremity radiculopathy, there are patients who have substantial associated back pain PURPOSE: To determine if patients with lumbar disc herniation (LDH) with substantial back pain improve with decompression alone. STUDY DESIGN: Longitudinal observational cohort PATIENT SAMPLE: Patients enrolled in the Quality and Outcomes Database (QOD) with LDH and a baseline back pain score ≥ 5 of 10 who underwent 1 or 2-level lumbar discectomy only OUTCOME MEASURES: Back and leg pain scores (0-10), Oswestry Disability Index (ODI), and EuroQoL 5D (EQ-5D)...
February 14, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29454129/delayed-post-traumatic-subacute-lumbar-subarachnoid-hematoma-case-report-and-review-of-the-literature
#8
Thiébaud Picart, Timothée Jacquesson, Emmanuel Jouanneau, Moncef Berhouma
BACKGROUND: Traumatic spinal subarachnoid hematoma, associated or not to a concurrent subdural hematoma has rarely been described. The evolution of such hematomas is heterogeneous. This study aims at defining the most accurate management which is currently not standardized. CASE DESCRIPTION: A 20-year-old man, victim of a high kinetic road accident five days before, suffering from several non-neurologic non-surgical vertebral fractures, complained of a sudden dorso-lumbar pain irradiating to his lower limbs...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454063/characterization-of-nanomedicines-a-reflection-on-a-field-under-construction-needed-for-clinical-translation-success
#9
REVIEW
Jean-Baptiste Coty, Christine Vauthier
The nanotechnology revolution offers many expectations for the improvement of medicine treatments. At present, nanomedicine (NM) development is hampered by methodological barriers for a better characterization and a wider understanding of their in vivo behavior. While regulatory agencies setup guidelines to support NM translation from bench to bedside, the gap is still hardly overcome by main nanomedicines. One lever for filling this gap is a better characterization, thus increasing the global knowledge about the NM itself but also validate the confidence in terms of batch to batch reproducibility of such complex nano-objects...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29454012/immunologic-effects-of-chronic-administration-of-tofacitinib-a-janus-kinase-inhibitor-in-cynomolgus-monkeys-and-rats-comparison-of-juvenile-and-adult-responses
#10
Mark Collinge, Douglas J Ball, Christopher J Bowman, Andrea L Nilson, Zaher A Radi, W Mark Vogel
Tofacitinib, an oral Janus kinase (JAK) inhibitor for treatment of rheumatoid arthritis, targets JAK1, JAK3, and to a lesser extent JAK2 and TYK2. JAK1/3 inhibition impairs gamma common chain cytokine receptor signaling, important in lymphocyte development, homeostasis and function. Adult and juvenile cynomolgus monkey and rat studies were conducted and the impact of tofacitinib on immune parameters (lymphoid tissues and lymphocyte subsets) and function (T-dependent antibody response (TDAR), mitogen-induced T cell proliferation) assessed...
February 14, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29453957/automatic-detection-of-the-duration-of-visual-static-and-dynamic-stimuli
#11
Szonya Durant, István Sulykos, István Czigler
The perception of the passing of time is fundamental to conscious experience. The duration of a sensory stimulus is one of its defining attributes, but it is not clear how this is encoded in the brain. This work explores whether the duration of a visual stimulus is an attribute that the brain can automatically adapt to and use to predict future stimulus durations. Visual mismatch negativity (vMMN) is an ERP component elicited, even when the stimuli are unattended, when an 'unexpected' visual stimulus appears amongst a series of expected stimuli in an 'oddball' paradigm...
February 14, 2018: Brain Research
https://www.readbyqxmd.com/read/29453899/the-role-of-dna-pk-in-aging-and-energy-metabolism
#12
REVIEW
Jay H Chung
DNA-dependent protein kinase (DNA-PK) is a very large holoenzyme comprised of the p470 kDa DNA-PK catalytic subunit (DNA-PK cs ) and the Ku heterodimer consisting of the p86 (Ku 80) and p70 (Ku 70) subunits. It is best known for its non-homologous end joining (NHEJ) activity, which repairs double-strand DNA (dsDNA) breaks (DSBs). As expected, the absence of DNA-PK activity results in sensitivity to ionizing radiation, which generates DSBs and defect in lymphocyte development, which requires NHEJ of the V(D)J region in the immunoglobulin and T cell receptor loci...
February 17, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29453857/psychosocial-student-functioning-in-comprehensive-dental-clinic-education-a-qualitative-study
#13
R Moore
INTRODUCTION: The aims were to describe first-year clinical dental students' psychosocial experiences in a known well-functioning comprehensive clinic teaching group (F+Grp) and a known dysfunctional group (Dys-Grp) and, thus, discover and describe phenomena related to psychosocial functioning of students. These groups were compared and contrasted regarding negative stress symptoms, perfectionism and coping with stress. METHODS: Eight female dental students (mean 26 years old), four in each group, were interviewed after the first clinical year about learning and emotional experiences...
February 17, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29453813/association-between-two-common-transitions-of-h2bfwt-gene-and-male-infertility-a-case-control-meta-and-structural-analysis
#14
M Teimouri, H Najaran, A Hosseinzadeh, T Mazoochi
H2BFWT is one of the testis-specific histones that plays a fundamental role in spermatogenesis, and single nucleotide polymorphisms (SNPs) in this gene may result in male infertility. This study aimed to investigate the association between -9C>T and 368A>G transitions of H2BFWT gene and male infertility through a case-control, meta-analysis, and a bioinformatics approach. In this case-control study, 490 subjects including 240 idiopathic infertile men and 250 healthy controls were included. The -9C>T and 368A>G SNPs genotyping were performed by a PCR-RFLP method...
February 17, 2018: Andrology
https://www.readbyqxmd.com/read/29453803/competition-for-nutrients-and-light-testing-advances-in-resource-competition-with-a-natural-phytoplankton-community
#15
Amanda Burson, Maayke Stomp, Emma Greenwell, Julia Grosse, Jef Huisman
A key challenge in ecology is to understand how nutrients and light affect the biodiversity and community structure of phytoplankton and plant communities. According to resource competition models, ratios of limiting nutrients are major determinants of the species composition. At high nutrient levels, however, species interactions may shift to competition for light, which might make nutrient ratios less relevant. The "nutrient-load hypothesis" merges these two perspectives, by extending the classic model of competition for two nutrients to include competition for light...
February 17, 2018: Ecology
https://www.readbyqxmd.com/read/29453734/post-operative-imaging-assessment-of-non-functioning-pituitary-adenomas
#16
REVIEW
Kunal S Patel, Sanjay Dhawan, Renzhi Wang, Bob S Carter, James Y Chen, Clark C Chen
BACKGROUND: Non-functioning pituitary adenomas (NFAs) are the most common pituitary tumors. There is significant variability in clinical practice in terms of post-operative imaging evaluation. The objective of this manuscript is to provide an exhaustive review of published articles pertaining to the post-operative imaging evaluation of NFAs. METHODS: The MEDLINE database was queried for studies investigating imaging for the post-operative evaluation of pituitary adenomas...
February 16, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29453669/physical-training-and-cardiac-rehabilitation-in-heart-failure-patients
#17
Cesare de Gregorio
Regardless of advances in medical and interventional treatment of cardiovascular disease (CVD), a limited number of patients attend a cardiac rehabilitation (CR) programme on a regular basis. Due to modern therapies more individuals will be surviving an acute cardiovascular event, but the expected burden of chronic heart failure will be increasing worldwide.However, both in high- and low-income countries, secondary prevention after an acute myocardial infarction or stroke has been implemented in less than a half of eligible patients...
February 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453615/vidarabine-an-anti-herpesvirus-agent-prevents-catecholamine-induced-arrhythmias-without-adverse-effect-on-heart-function-in-mice
#18
Kenji Suita, Takayuki Fujita, Wenqian Cai, Yuko Hidaka, Huiling Jin, Rajesh Prajapati, Masanari Umemura, Utako Yokoyama, Motohiko Sato, Björn C Knollmann, Satoshi Okumura, Yoshihiro Ishikawa
Sympathetic activation causes clinically important arrhythmias including atrial fibrillation (AF) and ventricular tachyarrhythmia. Although the usefulness of β-adrenergic receptor blockade therapy is widely accepted, its multiple critical side effects often prevent its initiation or continuation. The aim of this study is to determine the advantages of vidarabine, an adenylyl cyclase (AC)-targeted anti-sympathetic agent, as an alternative treatment for arrhythmia. We found that vidarabine, which we identified as a cardiac AC inhibitor, consistently shortens AF duration and reduces the incidence of sympathetic activation-induced ventricular arrhythmias...
February 16, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29453508/refractory-gastric-antral-ulcers-without-helicobacter-pylori-infection-and-non-steroidal-anti-inflammatory-drugs
#19
Hirotada Nishie, Hiromi Kataoka, Hiroyuki Kato, Taketo Suzuki, Hiroshi Ichikawa, Yu Nojiri, Mika Kitagawa, Yusuke Inagaki, Hiroyasu Iwasaki, Mamoru Tanaka, Takahito Katano, Yasuyuki Okamoto, Keiji Ozeki, Tsutomu Mizoshita, Takaya Shimura, Eiji Kubota, Satoshi Tanida, Takashi Joh
Herein, we describe a rare case of refractory gastric antral ulcers. A woman in her 50 s was admitted to Nagoya City University Hospital with epigastric pain after being diagnosed with gastric antral submucosal tumor at another hospital. Findings from esophagogastroduodenoscopy and endoscopic ultrasound examination revealed that the lesion was a gastric ulcer. The patient had no Helicobacter pylori infection and no recent history of using non-steroidal anti-inflammatory drugs. On the basis of these findings, we diagnosed this as a case of refractory gastric antral ulcer (RGAU)...
February 16, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29453495/comparison-of-concentrations-of-drugs-between-blood-samples-with-and-without-fluoride-additive-important-findings-for-%C3%AE-9-tetrahydrocannabinol-and-amphetamine
#20
Christopher Wiedfeld, Julia Krueger, Gisela Skopp, Frank Musshoff
Fluoride is a common stabilizing agent in forensic toxicology to avoid the frequent problem of degradation of drugs in blood samples especially described for cocaine. In cases only samples with addition of fluoride are available, it is a crucial question if also concentrations of common drugs other than cocaine (amphetamines, opiates and cannabinoids) are affected by fluoride. So far, there are only rare literature data available on discrepant results especially for Δ 9 -tetrahydrocannabinol (THC). In this study, comparative analysis of positive tested paired routine plasma/serum samples (n = 375), collected at the same time point (one device with and one without fluoride), was carried out with special focus on cannabinoids...
February 17, 2018: International Journal of Legal Medicine
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