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https://www.readbyqxmd.com/read/28351128/nanoparticles-of-titanium-and-zinc-oxides-as-novel-agents-in-tumor-treatment-a-review
#1
Janusz Bogdan, Joanna Pławińska-Czarnak, Joanna Zarzyńska
Cancer has become a global problem. On all continents, a great number of people are diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal for a great number of the ill, either as a result of a late diagnosis or due to inefficiency of therapies. The majority of the tumors are resistant to drugs. Thus, the search for new, more effective therapy methods continues. Recently, nanotechnology has been attributed with big expectations in respect of the cancer fight. That interdisciplinary field of science creates nanomaterials (NMs) and nanoparticles (NPs) that can be applied, e...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28351127/absorption-amelioration-of-amorphous-si-film-by-introducing-metal-silicide-nanoparticles
#2
Hui Sun, Hsuan-Chung Wu, Sheng-Chi Chen, Che-Wei Ma Lee, Xin Wang
Amorphous Si (a-Si) films with metal silicide are expected to enhance the absorption ability of pure a-Si films. In this present study, NiSi (20 nm)/Si (40 nm) and AlSi (20 nm)/Si (40 nm) bilayer thin films are deposited through radio frequency (RF) sputtering at room temperature. The influence of the film's composition and the annealing temperature on the film's optical absorption is investigated. The results show that all the NiSi/Si films and AlSi/Si films possess higher absorption ability compared to a pure a-Si film (60 nm)...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28351116/management-of-people-with-early-or-very-early-stage-hepatocellular-carcinoma-an-attempted-network-meta-analysis
#3
REVIEW
Avik Majumdar, Davide Roccarina, Douglas Thorburn, Brian R Davidson, Emmanuel Tsochatzis, Kurinchi Selvan Gurusamy
BACKGROUND: Hepatocellular carcinoma (primary liver cancer) is classified in many ways. The Barcelona Clinic Liver Cancer (BCLC) group staging classifies the cancer based on patient's life expectancy. People with very early- or early-stage hepatocellular carcinoma have single tumour or three tumours of maximum diameter of 3 cm or less, Child-Pugh status A to B, and performance status 0 (fully functional). Management of hepatocellular carcinoma is uncertain. OBJECTIVES: To assess the comparative benefits and harms of different interventions used in the treatment of early or very early hepatocellular carcinoma through a network meta-analysis and to generate rankings of the available interventions according to their safety and efficacy...
March 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28350949/state-of-the-art-in-degenerative-cervical-myelopathy-an-update-on-current-clinical-evidence
#4
Jefferson R Wilson, Lindsay A Tetreault, Jun Kim, Mohammed F Shamji, James S Harrop, Thomas Mroz, Samuel Cho, Michael G Fehlings
Degenerative cervical myelopathy (DCM) is a common cause of spinal cord dysfunction that confronts clinicians on a daily basis. Research performed over the past few decades has provided improved insight into the diagnosis, evaluation, and treatment of this disorder. We aim to provide clinicians with an update regarding the state of the art in DCM, focusing on more recent research pertaining to pathophysiology, natural history, treatment, consideration of the minimally symptomatic patient, surgical outcome prediction, and outcome measurement...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28350887/auditory-steady-state-responses-and-cochlear-implants-modeling-the-artifact-response-mixture-in-the-perspective-of-denoising
#5
Faten Mina, Virginie Attina, Yvan Duroc, Evelyne Veuillet, Eric Truy, Hung Thai-Van
Auditory steady state responses (ASSRs) in cochlear implant (CI) patients are contaminated by the spread of a continuous CI electrical stimulation artifact. The aim of this work was to model the electrophysiological mixture of the CI artifact and the corresponding evoked potentials on scalp electrodes in order to evaluate the performance of denoising algorithms in eliminating the CI artifact in a controlled environment. The basis of the proposed computational framework is a neural mass model representing the nodes of the auditory pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28350884/impacts-of-representing-sea-level-rise-uncertainty-on-future-flood-risks-an-example-from-san-francisco-bay
#6
Kelsey L Ruckert, Perry C Oddo, Klaus Keller
Rising sea levels increase the probability of future coastal flooding. Many decision-makers use risk analyses to inform the design of sea-level rise (SLR) adaptation strategies. These analyses are often silent on potentially relevant uncertainties. For example, some previous risk analyses use the expected, best, or large quantile (i.e., 90%) estimate of future SLR. Here, we use a case study to quantify and illustrate how neglecting SLR uncertainties can bias risk projections. Specifically, we focus on the future 100-yr (1% annual exceedance probability) coastal flood height (storm surge including SLR) in the year 2100 in the San Francisco Bay area...
2017: PloS One
https://www.readbyqxmd.com/read/28350856/a-fat-derived-metabolite-regulates-a-peptidergic-feeding-circuit-in-drosophila
#7
Do-Hyoung Kim, Minjung Shin, Sung-Hwan Jung, Young-Joon Kim, Walton D Jones
Here, we show that the enzymatic cofactor tetrahydrobiopterin (BH4) inhibits feeding in Drosophila. BH4 biosynthesis requires the sequential action of the conserved enzymes Punch, Purple, and Sepiapterin Reductase (Sptr). Although we observe increased feeding upon loss of Punch and Purple in the adult fat body, loss of Sptr must occur in the brain. We found Sptr expression is required in four adult neurons that express neuropeptide F (NPF), the fly homologue of the vertebrate appetite regulator neuropeptide Y (NPY)...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28350853/impacts-of-120-years-of-fertilizer-addition-on-a-temperate-grassland-ecosystem
#8
Jonathan Kidd, Peter Manning, Janet Simkin, Simon Peacock, Elizabeth Stockdale
The widespread application of fertilizers has greatly influenced many processes and properties of agroecosystems, and agricultural fertilization is expected to increase even further in the future. To date, most research on fertilizer impacts has used short-term studies, which may be unrepresentative of long-term responses, thus hindering our capacity to predict long-term impacts. Here, we examined the effects of long-term fertilizer addition on key ecosystem properties in a long-term grassland experiment (Palace Leas Hay Meadow) in which farmyard manure (FYM) and inorganic fertilizer treatments have been applied consistently for 120 years in order to characterize the experimental site more fully and compare ecosystem responses with those observed at other long-term and short-term experiments...
2017: PloS One
https://www.readbyqxmd.com/read/28350831/post-term-growth-and-cognitive-development-at-5-years-of-age-in-preterm-children-evidence-from-a-prospective-population-based-cohort
#9
Laure Simon, Simon Nusinovici, Cyril Flamant, Bertrand Cariou, Valérie Rouger, Géraldine Gascoin, Dominique Darmaun, Jean-Christophe Rozé, Matthieu Hanf
While the effects of growth from birth to expected term on the subsequent development of preterm children has attracted plentiful attention, less is known about the effects of post-term growth. We aimed to delineate distinct patterns of post-term growth and to determine their association with the cognitive development of preterm children. Data from a prospective population-based cohort of 3,850 surviving infants born at less than 35 weeks of gestational age were used. Growth was assessed as the Body Mass Index (BMI) Z-scores at 3, 9, 18, 24, 36, 48, and 60 months...
2017: PloS One
https://www.readbyqxmd.com/read/28350829/spatio-temporal-variation-of-fish-taxonomic-composition-in-a-south-east-asian-flood-pulse-system
#10
Heng Kong, Mathieu Chevalier, Pascal Laffaille, Sovan Lek
The Tonle Sap Lake (TSL) is a flood-pulse system. It is the largest natural lake in South-East Asia and constitutes one of the largest fisheries over the world, supporting the livelihood of million peoples. Nonetheless, the Mekong River Basin is changing rapidly due to accelerating water infrastructure development (hydropower, irrigation, flood control, and water supply) and climate change, bringing considerable modifications to the annual flood-pulse of the TSL. Such modifications are expected to have strong impacts on fish biodiversity and abundance...
2017: PloS One
https://www.readbyqxmd.com/read/28350828/clustering-of-four-major-lifestyle-risk-factors-among-korean-adults-with-metabolic-syndrome
#11
Shin Ha, Hui Ran Choi, Yo Han Lee
The purpose of this study was to investigate the clustering pattern of four major lifestyle risk factors-smoking, heavy drinking, poor diet, and physical inactivity-among people with metabolic syndrome in South Korea. There were 2,469 adults with metabolic syndrome aged 30 years or older available with the 5th Korean National Health and Nutrition Examination Survey dataset. We calculated the ratio of the observed to expected (O/E) prevalence for the 16 different combinations and the prevalence odds ratios (POR) of four lifestyle risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/28350777/understanding-brain-reorganization-in-infants-with-perinatal-stroke-through-neuroexcitability-and-neuroimaging
#12
Chao-Ying Chen, Michael Georgieff, Jed Elison, Mo Chen, James Stinear, Bryon Mueller, Raghavendra Rao, Kyle Rudser, Bernadette Gillick
PURPOSE: The primary aim of this proposed study is to evaluate brain reorganization patterns in infants with perinatal stroke between 3 and 5 months of age using transcranial magnetic stimulation and magnetic resonance imaging, with the addition of the General Movements Assessment. A secondary aim is to demonstrate feasibility and safety of infant-appropriate brain assessment protocols. METHODS: Ten infants with perinatal stroke will be enrolled. In this exploratory study, infants will first receive magnetic resonance imaging scanning during natural sleep to examine their corticospinal tract integrity...
April 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28350636/the-impact-of-hospital-health-network-affiliation-on-discharge-communication-preferences-of-primary-care-providers
#13
David Y Ming, Alyssa M Stephany, John A Gallis, Benjamin J Powers
Primary care physicians (PCPs) experience differential postdischarge access to electronic health records, depending upon affiliation with the discharging hospital's health network. To better understand whether this affiliation impacts discharge communication preferences, we surveyed a convenience sample of PCPs in and out of our hospital's health network. We also surveyed hospitalists and compared PCPs' and hospitalists' responses. We found that PCP discharge communication preferences differed by hospital health network affiliation...
March 27, 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28350544/efimov-physics-a-review
#14
Pascal Naidon, Shimpei Endo
This article reviews theoretical and experimental advances in Efimov physics, an array of quantum few-body and many-body phenomena arising for particles interacting via short-range resonant interactions, that is based on the appearance of a scale-invariant three-body attraction theoretically discovered by Vitaly Efimov in 1970. This three-body effect was originally proposed to explain the binding of nuclei such as the triton and the Hoyle state of carbon-12, and later considered as a simple explanation for the existence of some halo nuclei...
March 28, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28350504/royal-darwinian-demons-enforced-changes-in-reproductive-efforts-do-not-affect-the-life-expectancy-of-ant-queens
#15
Alexandra Schrempf, Julia Giehr, Ramona Röhrl, Sarah Steigleder, Jürgen Heinze
One of the central tenets of life-history theory is that organisms cannot simultaneously maximize all fitness components. This results in the fundamental trade-off between reproduction and life span known from numerous animals, including humans. Social insects are a well-known exception to this rule: reproductive queens outlive nonreproductive workers. Here, we take a step forward and show that under identical social and environmental conditions the fecundity-longevity trade-off is absent also within the queen caste...
April 2017: American Naturalist
https://www.readbyqxmd.com/read/28350502/complex-relationships-between-competing-guilds-along-large-scale-environmental-gradients
#16
Remi Vergnon, Mark K J Ooi, Robert P Freckleton
Despite much research over the past 30 years, there is still little general understanding of how the outcomes of interactions vary along environmental gradients, particularly at large geographic scales. A simple expectation is that decreasing environmental quality should reduce densities of competitors and hence the effects of competition should weaken in poorer environments. A counterintuitive consequence is that associations between densities of competitors might change from negative to positive as environments decrease in quality...
April 2017: American Naturalist
https://www.readbyqxmd.com/read/28350500/local-adaptation-interacts-with-expansion-load-during-range-expansion-maladaptation-reduces-expansion-load
#17
Kimberly J Gilbert, Nathaniel P Sharp, Amy L Angert, Gina L Conte, Jeremy A Draghi, Frédéric Guillaume, Anna L Hargreaves, Remi Matthey-Doret, Michael C Whitlock
The biotic and abiotic factors that facilitate or hinder species range expansions are many and complex. We examine the impact of two genetic processes and their interaction on fitness at expanding range edges: local maladaptation resulting from the presence of an environmental gradient and expansion load resulting from increased genetic drift at the range edge. Results from spatially explicit simulations indicate that the presence of an environmental gradient during range expansion reduces expansion load; conversely, increasing expansion load allows only locally adapted populations to persist at the range edge...
April 2017: American Naturalist
https://www.readbyqxmd.com/read/28350469/synthesis-of-sugar-boronic-acid-derivatives-a-class-of-potential-agents-for-boron-neutron-capture-therapy
#18
Daniela Imperio, Erika Del Grosso, Silvia Fallarini, Grazia Lombardi, Luigi Panza
To date, sugar analogues that contain boronic acids as substitutes for hydroxyl groups are a class of compounds nearly unknown in the literature. The challenging synthesis of two sugar-boronic acid analogues is described, and data are retrieved on their solution behavior, stability, and toxicity. As these compounds were expected to mimic the behavior of carbohydrates, they were tested in regards to their future development as potential boron neutron capture therapy agents.
March 28, 2017: Organic Letters
https://www.readbyqxmd.com/read/28346925/microbiota-and-necrotizing-enterocolitis
#19
Sanjay Patole
Necrotizing enterocolitis (NEC) is an acquired gastrointestinal inflammatory condition with significant mortality and morbidity in preterm very low birth weight infants. The interplay between toll-like receptors, bacterial endotoxins, developmentally regulated excessive proinflammatory responses of the immature innate immune system, hypoxia, ischemia, reperfusion, free radicals, and the presence of substrates and bacterial endotoxins is thought to play an important role in the pathogenesis of NEC. The association (cause?) of various microbes (bacteria, viruses, and fungi) with NEC has intrigued researchers for many years...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346870/-to-the-victor-go-the-spoils-infants-expect-resources-to-align-with-dominance-structures
#20
Elizabeth A Enright, Hyowon Gweon, Jessica A Sommerville
Previous research has found that within the first year of life infants possess rich knowledge about social structures (i.e., that some individuals are dominant over other individuals) as well as expectations about resource distributions (i.e., that resources are typically distributed equally to recipients). We investigated whether infants' expectations about resource distribution can be modulated by information about the dominance structure between the recipients. We first replicated the finding that infants attribute a stable dominance hierarchy to a pair of individuals when their goals conflicted and one individual yielded to the other (Expt...
March 24, 2017: Cognition
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