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https://www.readbyqxmd.com/read/29909488/histological-changes-of-superficial-esophageal-squamous-cell-carcinoma-after-preoperative-chemotherapy
#1
Takahito Sugase, Tomoki Makino, Makoto Yamasaki, Koji Tanaka, Tadayoshi Hashimoto, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Masayuki Mano, Eiichi Morii, Masaki Mori, Yuichiro Doki
INTRODUCTION: We aimed to analyze the clinical and histological effects of chemotherapy in superficial esophageal squamous cell carcinoma (SESCC). METHODS: We analyzed tumor samples from five patients with cT1bN1M0 who underwent subtotal esophagectomy following two courses of a new triplet chemotherapy regimen including docetaxel, cisplatin, and 5-fluorouracil (DCF). To assess the histological effects of chemotherapy, resected specimens were analyzed by macroscopic examination, hematoxylin & eosin (HE) staining, immunohistochemical (IHC) staining (p53, Ki-67 and cytokeratin) and periodic acid-Schiff (PAS) staining...
June 16, 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29909091/clinical-and-pharmacogenetic-determinants-of-5-fluorouracyl-leucovorin-irinotecan-toxicity-results-of-the-petacc-3-trial
#2
Sabine Tejpar, Pu Yan, Hubert Piessevaux, Daniel Dietrich, Peter Brauchli, Dirk Klingbiel, Roberto Fiocca, Mauro Delorenzi, Fred Bosman, Arnaud D Roth
PURPOSE: Irinotecan (CPT-11) in combination with 5-fluorouracil (5FU) is widely used in the treatment of colorectal cancer. We assessed potential clinical variables that may predict toxicity and more specifically the role of UGT1A1 polymorphisms associated with irinotecan toxicity. We used data from the PETACC3 trial, which randomised patients in adjuvant setting to 6 months of leucovorin (LV) and 5FU (LV5/FU2) or LV5/FU2 + irinotecan. PATIENTS AND METHODS: Clinical and toxicity data were available for 2982 patients, DNA was available for 1200 (40%) of these patients...
June 14, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29908244/prompt-treatment-with-uridine-triacetate-improves-survival-and-reduces-toxicity-due-to-fluorouracil-and-capecitabine-overdose-or-dihydropyrimidine-dehydrogenase-deficiency
#3
Rolando A G Garcia, Joel A Saydoff, Michael K Bamat, Reid W von Borstel
Uridine triacetate has been shown to be an effective antidote against mortality and toxicity caused by either overdoses or exaggerated susceptibility to the widely used anticancer agents 5-fluorouracil (5-FU) and capecitabine. However, a direct assessment of efficacy based on when emergency treatment was initiated was not clinically feasible. In this study we used mouse models of 5-FU overdose and of dihydropyrimidine dehydrogenase (DPD) deficiency to compare the efficacy of uridine triacetate in reducing toxicity and mortality when treatment was initiated at time points from 4 to 144 h after administration of 5-FU...
June 13, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29906015/randomized-and-controlled-pilot-study-of-the-pragmatic-use-of-mobile-phone-based-follow-up-of-actinic-keratoses-treated-with-topical-5-fluorouracil
#4
Suzana S Bosanac, Victoria Nguyen, Donna Bui, Daniel B Eisen, Raja K Sivamani
Store-and-forward teledermatology involves transmission of a patient's images to a healthcare provider and subsequent response from the provider about the diagnosis or management. Furthermore, teledermatology in which mobile phones (e.g. smartphones) are utilized for communication between the patient and their provider is referred to as mobile-teledermatology. In this study, we investigate the use of mobile-teledermatology in the management of actinic keratoses. We demonstrate that mobile-teledermatology may enhance communication between the patient and their provider when managing cutaneous disease and that even individuals in older age groups are highly satisfied with this type of follow up...
April 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29906006/topical-application-of-5-fluorouracil-5-percent-cream-associated-with-severe-neutropenia-discussion-of-a-case-and-review-of-systemic-reactions-after-topical-treatment-with-5-fluorouracil
#5
Philip R Cohen
5-fluorouracil, a fluoropyrimidine antineoplastic drug, is used to topically treat actinic keratoses. Local skin reactions to the medication are common and anticipated. However, severe adverse events from topical 5-fluorouracil are rare and unexpected. A 69-year-old man with a lower lip actinic keratosis developed severe neutropenia on day 11 of topical 5-fluorouracil treatment - after 14 applications. After receiving a subcutaneous injection of filgrastim, his neutrophil count normalized. The PubMed database was used to search the following terms: agranulocytosis, cream, 5-fluorouracil, granulocytopenia, neutropenia, severe, systemic, topical, and toxicity...
April 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29905927/multicenter-randomized-double-blind-phase-2-trial-of-folfiri-with-regorafenib-or-placebo-as-second-line-therapy-for-metastatic-colorectal-cancer
#6
Hanna K Sanoff, Richard M Goldberg, Anastasia Ivanova, Seamus O'Reilly, Samer S Kasbari, Richard D Kim, Ray McDermott, Dominic T Moore, William Zamboni, William Grogan, Allen Lee Cohn, Tanios S Bekaii-Saab, Gregory Leonard, Theresa Ryan, Olugbenga O Olowokure, Nishan H Fernando, John McCaffrey, Bassel F El-Rayes, Anne M Horgan, Gary Bradley Sherrill, George Hosni Yacoub, Bert H O'Neil
BACKGROUND: Regorafenib, a multikinase inhibitor that inhibits angiogenesis, growth, and proliferation, prolongs survival as monotherapy in patients with refractory colorectal cancer. This international, double-blind, placebo-controlled, multicenter trial assessed the efficacy of regorafenib with folinic acid, fluorouracil, and irinotecan (FOLFIRI) as a second-line treatment for metastatic colorectal cancer. METHODS: Patients with metastatic colorectal cancer who progressed on first-line oxaliplatin and fluoropyrimidine enrolled at 45 sites in the United States and Ireland...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29904586/recent-advances-in-field-cancerization-and-management-of-multiple-cutaneous-squamous-cell-carcinomas
#7
REVIEW
Sean R Christensen
Cutaneous squamous cell carcinoma (SCC) is among the most common cancers in humans, and many patients with SCC will develop multiple tumors within their lifetime. The field cancerization concept, originally proposed over 60 years ago, hypothesized that multiple primary cancers may arise simultaneously and coexist with subclinical precursor lesions within a defined field. Genetic sequencing of SCC and precursor lesions has identified what may be the earliest clonal proliferations in SCC development and confirmed that field cancerization in the skin is mediated by ultraviolet radiation...
2018: F1000Research
https://www.readbyqxmd.com/read/29901103/timed%C3%A2-flat-infusion-of-5%C3%A2-fluorouracil-with-docetaxel-and-oxaliplatin-as-first%C3%A2-line-treatment-of-gastroesophageal-adenocarcinoma-a-single-institution-experience-with-the-fd-fox-regimen
#8
Alessio Cortellini, Katia Cannita, Alessandro Parisi, Olga Venditti, Paola Lanfiuti Baldi, Berardo De Berardis, Roberto Vicentini, Vincenzo Vicentini, Lucilla Verna, Giampiero Porzio, Corrado Ficorella
To date, there is no consensus regarding first‑line chemotherapy for patients with HER2‑negative, locally advanced/metastatic gastric cancer (a/m GC). In the present study we reported a retrospective case‑series of patients treated with a weekly regimen containing timed‑flat infusion of 5‑fluorouracil (TFI/5‑FU), docetaxel and oxaliplatin. From June 2007 to July 2017, 32 consecutive a/m GC patients were treated with first‑line standard (st) or modulated (mod) 'FD/FOx' regimen: Weekly 12 h (from 10...
June 6, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29899863/psmd4-is-a-novel-therapeutic-target-in-chemoresistant-colorectal-cancer-activated-by-cytoplasmic-localization-of-nrf2
#9
Ya-Min Cheng, Po-Lin Lin, De-Wei Wu, Lee Wang, Chi-Chou Huang, Huei Lee
Nuclear Nrf2 (nNrf2) binding to the antioxidant response element may promote chemoresistance in colorectal cancer. However, the shuttling of Nrf2 between cytoplasm and nucleus in colon cancer cells has revealed the possibility that cytoplasmic location of Nrf2 (cNrf2) may play a specific role in chemoresistance. Transfection of a nuclear location sequence (NLS)-wild-type or NLS-mutated Nrf2 expression vector into a stable shNrf2 HCT116 clone using the MTT assay to examine whether chemoresistance induced by cNrf2 may be greater than nNrf2...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29899860/steviol-a-natural-product-inhibits-proliferation-of-the-gastrointestinal-cancer-cells-intensively
#10
Junming Chen, Yongmei Xia, Xiaochen Sui, Qingrui Peng, Tongtong Zhang, Jian Li, Jue Zhang
New anticancer agents with lower toxicity have been always urged because of drug resistance associated with overused chemotherapy agents. In this study, steviol, a colonic metabolite of natural sweetener and also a component in leaves of stevia rebaudiana bertoni , was found to possess intensive anticancer activity on the human gastrointestinal cancer cells. Steviol inhibited six human gastrointestinal cancer cells intensively as 5-fluorouracil did at 100 μg/mL. The inhibition mechanism follows mitochondrial apoptotic pathway that was evidenced by increase of Bax/Bcl-2 ratio, activation of p21 and p53; and caspase 3-independent mechanism was also involved...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29899208/chrysin-attenuates-cell-viability-of-human-colorectal-cancer-cells-through-autophagy-induction-unlike-5-fluorouracil-oxaliplatin
#11
Yueh-Ming Lin, Chih-I Chen, Yi-Ping Hsiang, Yung-Chia Hsu, Kung-Chuan Cheng, Pei-Hsuan Chien, Hsiao-Lin Pan, Chien-Chang Lu, Yun-Ju Chen
Chemotherapeutic 5-fluorouracil (5-FU) combined with oxaliplatin is often used as the standard treatment for colorectal cancer (CRC). The disturbing side effects and drug resistance commonly observed in chemotherapy motivate us to develop alternative optimal therapeutic options for CRC treatment. Chrysin, a natural and biologically active flavonoid abundant in propolis, is reported to have antitumor effects on a few CRCs. However, whether and how chrysin achieves similar effectiveness to the 5-FU combination is not clear...
June 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29898269/metastatic-pancreatic-ductal-adenocarcinoma-diagnosis-and-treatment-with-a-view-to-the-future
#12
Adrian M J Pokorny, Venessa T Chin, Adnan M Nagrial, Desmond Yip, Lorraine A Chantrill
Metastatic pancreatic ductal adenocarcinoma (mPDAC) is a lethal disease with a poor 5-year survival. Systemic treatments can be used to control symptoms and prolong life. Cytotoxic chemotherapies are commonly administered, with combination treatments, such as fluorouracil, folinic acid, irinotecan and oxaliplatin (FOLFIRINOX) or nab-paclitaxel and gemcitabine showing the largest clinical benefits. Newer genomic classifications of PDAC may provide a rationale for targeted therapies or immunotherapies, although at present these remain largely experimental...
June 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29890672/in-vitro-antioxidant-activities-of-phenols-and-oleanolic-acid-from-mango-peel-and-their-cytotoxic-effect-on-a549-cell-line
#13
Xuelian Bai, Tongfei Lai, Ting Zhou, Yicong Li, Xiuting Li, Huawei Zhang
Mango peel, the main by-product of juice processing, possesses appreciable quantities of bioactive phenolic compounds and is worthy of further utilization. The present work reports for the first time the HPLC analysis and in vitro antioxidant evaluation of mango peel phenols (MPPs) and their cytotoxic effect on the A549 lung cancer cell line. These results indicated that mango peel has the total phenolic content of 723.2 ± 0.93 mg·kg−1 dry mango peel (DMP), which consisted mainly of vanillic aldehyde, caffeic acid, chlorogenic acid, gallic acid, procyanidin B₂ and oleanolic acid...
June 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29890207/hdac1-induced-epigenetic-silencing-of-aspp2-promotes-cell-motility-tumour-growth-and-drug-resistance-in-renal-cell-carcinoma
#14
Huayi Li, Xingwen Wang, Cheng Zhang, Yiwei Cheng, Miao Yu, Kunming Zhao, Wenjie Ge, Anyong Cai, Yao Zhang, Fengtong Han, Ying Hu
Renal cell carcinoma (RCC) is highly resistant to chemotherapies. The lack of efficacious treatment for metastatic RCC has led to a poor 5-year survival rate. Here, we found that Apoptosis-stimulating protein of p53-2(ASPP2) was frequently decreased in primary RCC tissues in comparison with non-tumoural kidney controls. Decreased ASPP2 was correlated with high grades and poor outcomes of RCC. Further studies revealed that ASPP2 downregulation promoted EMT and increased resistance to 5-Fluorouracil (5-FU)-induced apoptosis...
June 8, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29889302/conventional-and-combination-topical-photodynamic-therapy-for-basal-cell-carcinoma-systematic-review-and-meta-analysis
#15
REVIEW
N J Collier, A K Haylett, T H Wong, C A Morton, S H Ibbotson, K E McKenna, R Mallipeddi, H Moseley, D Seukeran, K A Ward, M F Mohd Mustapa, L S Exton, A C Green, L E Rhodes
BACKGROUND: Topical photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC). OBJECTIVES: Compare efficacy, cosmesis and tolerability of PDT for BCC with alternative treatments. METHODS: MEDLINE/PubMed/EMBASE/CENTRAL databases were searched from inception until 1 September 2017. Included studies were randomised controlled trials (RCTs) of PDT for nodular (n) and superficial (s) BCC reporting at least one of the outcomes: clearance at 3 months, and sustained at 1 or 5 years; recurrence at ≥1 year; cosmesis; adverse events; tolerability...
June 11, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29882102/low-dose-continuous-5-fluorouracil-combined-with-leucovorin-nab-paclitaxel-oxaliplatin-and-bevacizumab-for-patients-with-advanced-pancreatic-cancer-a-retrospective-analysis
#16
William H Isacoff, Howard A Reber, Rudolph Bedford, William Hoos, Lola Rahib, Alexander Upfill-Brown, Timothy Donahue, O Joe Hines
BACKGROUND: Continuous-infusion 5-fluorouracil (5FU) and calcium leucovorin plus nab-paclitaxel and oxaliplatin have been shown to be active in patients with pancreatic cancer. As a protracted low-dose infusion, 5FU is antiangiogenic, and has synergy with bevacizumab. As shown in the treatment of breast cancer, bevacizumab and nab-paclitaxel are also synergetic. OBJECTIVE: In this paper we retrospectively analyze the survival of 65 patients with advanced pancreatic cancer who were treated with low-dose continuous (metronomic) chemotherapy given in conjunction with conventional anti-VEGF therapy...
June 7, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29882070/ct-attenuation-of-liver-metastases-before-targeted-therapy-is-a-prognostic-factor-of-overall-survival-in-colorectal-cancer-patients-results-from-the-randomised-open-label-fire-3-aio-krk0306-trial
#17
Matthias F Froelich, Volker Heinemann, Wieland H Sommer, Julian W Holch, Franziska Schoeppe, Nina Hesse, Alena B Baumann, Wolfgang G Kunz, Maximilian F Reiser, Jens Ricke, Melvin D'Anastasi, Sebastian Stintzing, Dominik P Modest, Philipp M Kazmierczak, Felix O Hofmann
OBJECTIVES: To assess the prognostic value of pre-therapeutic computed tomography (CT) attenuation of liver metastases for overall survival (OS) in metastatic colorectal cancer (mCRC). METHODS: In the open-label, randomised, prospective phase-III FIRE-3 trial, patients with histologically confirmed mCRC received fluorouracil (5-FU), leucovorin and irinotecan (FOLFIRI) with either cetuximab or bevacizumab. Participating patients gave written informed consent prior to study entry...
June 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29881405/de-esterified-tragacanth-microspheres-loaded-into-eudragit-s-100-coated-capsules-for-colon-targeted-delivery
#18
Ehsan Ahmadi, Komail Sadrjavadi, Ghobad Mohammadi, Ali Fattahi
The objective of this study was to develop a novel bacterially-triggered micro-particular system of de-esterified tragacanth (DET) in combination with Eudragit S-100 coated capsules for colon drug delivery of 5-fluorouracil (5-FU) using microemulsion method. The loading study was conducted at different drug-to-polymer ratios and cross-linker concentrations. The maximum loading efficiency was achieved, 44.1% at 1:5 drug-to-polymer ratio and 0.7% cross-linker concentration. The FTIR results also confirmed the encapsulation of 5-FU in microspheres...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29881279/effects-and-safety-of-triamcinolone-acetonide-controlled-common-therapy-in-keloid-treatment-a-bayesian-network-meta-analysis
#19
Zhenyu Zhang, Lihui Cheng, Ru Wang, Ying Cen, Zhengyong Li
Background: Triamcinolone acetonide (TAC) is used frequently in the treatment of keloid scars, but has presented controversial results. In this study, we aim to evaluate the effectiveness of TAC compared with other common therapies used in keloid treatment. Methods: MEDLINE, Embase, Web of Science and the Cochrane Library databases were searched until January 2018. Key data were extracted from eligible randomized controlled trials. Both pairwise and network meta-analyses were conducted for synthesizing data from eligible studies...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29879526/implantable-chemothermal-brachytherapy-seeds-a-synergistic-approach-to-brachytherapy-using-polymeric-dual-drug-delivery-and-hyperthermia-for-malignant-solid-tumor-ablation
#20
Ludwig Erik Aguilar, Reju George Thomas, Myeong Ju Moon, Yong Yeon Jeong, Chan Hee Park, Cheol Sang Kim
Chemothermal brachytherapy seeds have been developed using a combination of polymeric dual drug chemotherapy and alternating magnetic field induced hyperthermia. The synergistic effect of chemotherapy and hyperthermia brachytherapy has been investigated in a way that has never been performed before, with an in-depth analysis of the cancer cell inhibition property of the new system. A comprehensive in vivo study on athymic mice model with SCC7 tumor has been conducted to determine optimal arrays and specifications of the chemothermal seeds...
June 4, 2018: European Journal of Pharmaceutics and Biopharmaceutics
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