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5 fluorouracil

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https://www.readbyqxmd.com/read/29048671/adoptive-immunotherapy-combined-with-fp-treatment-for-head-and-neck-cancer-an-in%C3%A2-vitro-study
#1
Mayako Nishio-Nagai, Susumu Suzuki, Kazuhiro Yoshikawa, Ryuzo Ueda, Yoshiaki Kazaoka
FP treatment, which combines 5-fluorouracil (5-FU) and cisplatin (CDDP) chemotherapy, is widely used for treatment of advanced head and neck cancer (HNC). It has been suggested that these drugs cause immunomodulation in the cancer microenvironment, for example, downregulation of immunosuppressive cells such as regulatory T-cells (Tregs) and myeloid-derived suppressive cells (MDSCs), activating dendritic cells (DCs), and upregulation of tumor antigens and major histocompatibility complex (MHC) molecules in cancer cells leads to enhancement of cancer immunity, which is important in cancer treatment, as well as providing a direct killing effect...
October 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29048661/combination-of-fgfr4-inhibitor-blu9931-and-5-fluorouracil-effects-on-the-biological-characteristics-of-colorectal-cancer-cells
#2
Dongbao Jiang, Jingjing Li, Jie Li, Min Wang, Chao Han, Xinru Wang, Chunlin Zhao, Yanwei Ye
The aim of this study was to explore the effects of single agent treatments and combination of Blu9931 and 5-fluorouracil (5-FU) on the biological characteristics of colorectal cancer cells and its mechanism. Blu9931 is the first selective small molecule inhibitor of the fibroblast growth factor receptor 4 (FGFR4) and exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. The colorectal cancer cells HCT116 and SW620 with high expression of FGFR4 were selected for a series of functional tests including cell viability, cell proliferation, apoptosis and cell cycle detection...
October 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29045885/fabrication-and-use-of-plga-based-formulations-designed-for-modified-release-of-5-fluorouracil
#3
REVIEW
Nattawut Leelakanok, Sean Geary, Aliasger Salem
5-fluorouracil (5-FU) is a chemotherapeutic agent that has been used for the treatment of a variety of malignancies since its initial introduction to the clinic in 1957.(1) Due to its short biological half-life, multiple dosings are generally required to maintain effective 5-FU plasma concentrations throughout the therapeutic period. Clinical studies have shown that continuous 5-FU administration is generally superior to bolus injection as exhibited by lower toxicities and increased therapeutic efficacy.(2,3) Optimal therapeutic efficacy, however, is often compromised by the limiting therapeutic index...
October 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29045820/five-year-results-of-a-randomized-controlled-trial-comparing-effectiveness-of-photodynamic-therapy-topical-imiquimod-and-topical-5-fluorouracil-in-patients-with-superficial-basal-cell-carcinoma
#4
Maud H E Jansen, Klara Mosterd, Aimee H M M Arits, Marieke H Roozeboom, Anja Sommer, Brigitte A B Essers, Han P A van Pelt, Patricia J F Quaedvlieg, Peter M Steijlen, Patty J Nelemans, Nicole W J Kelleners-Smeets
For the treatment of superficial basal cell carcinoma, a prospective non-inferiority randomized controlled multicenter trial with 601 patients showed that 5% imiquimod cream was superior and 5-fluorouracil cream not inferior to methyl aminolevulinate photodynamic therapy (MAL-PDT) at one and three year post-treatment. No definite conclusion could be drawn regarding the superiority of imiquimod over 5-fluorouracil. We now present the five-year follow-up results according to the intention-to-treat analysis. Five years post-treatment the probability of tumor-free survival was 62...
October 15, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29045553/randomized-controlled-trial-of-s-1-versus-docetaxel-in-patients-with-non-small-cell-lung-cancer-previously-treated-with-platinum-based-chemotherapy-east-asia-s-1-trial-in-lung-cancer
#5
H Nokihara, S Lu, T S K Mok, K Nakagawa, N Yamamoto, Y K Shi, L Zhang, R A Soo, J C Yang, S Sugawara, M Nishio, T Takahashi, K Goto, J Chang, M Maemondo, Y Ichinose, Y Cheng, W T Lim, S Morita, T Tamura
Background: Chemotherapy remains a viable option for the management of advanced non-small-cell lung cancer (NSCLC) despite recent advances in molecular targeted therapy and immunotherapy. We evaluated the efficacy of oral 5-fluorouracil-based S-1 as second- or third-line therapy compared with standard docetaxel therapy in patients with advanced NSCLC. Patients and methods: Patients with advanced NSCLC previously treated with ≥1 platinum-based therapy were randomized 1:1 to docetaxel (60 mg/m2 in Japan, 75mg/m2 at all other study sites; day 1 in a 3-week cycle) or S-1 (80-120 mg/day, depending on body surface area; days 1-28 in a 6-week cycle)...
September 29, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045513/dpyd-genotype-guided-dose-individualization-to-improve-patient-safety-of-fluoropyrimidine-therapy-call-for-a-drug-label-update
#6
L M Henricks, F L Opdam, J H Beijnen, A Cats, J H M Schellens
The fluoropyrimidine anticancer drugs, especially 5-fluorouracil (5-FU) and capecitabine, are frequently prescribed for several types of cancer, including breast, colorectal, head and neck and gastric cancer. In the current drug labels of 5-FU and capecitabine in the European Union and the United States of America no adaptive dosing strategies are incorporated for polymorphic metabolism of 5-FU.Although treatment with fluoropyrimidines is generally well tolerated, a major clinical limitation is that a proportion of the treated population experiences severe, sometimes life-threatening, fluoropyrimidine-related toxicity...
August 2, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29042944/pien-tze-huang-induces-apoptosis-and-inhibits-proliferation-of-5-fluorouracil-resistant-colorectal-carcinoma-cells-via-increasing-mir-22-expression
#7
Zhaorong Chen, Aling Shen, Liya Liu, Youqin Chen, Jianfeng Chu, Qiaoyan Cai, Fei Qi, Thomas Joseph Sferra, Jun Peng
The well-known traditional Chinese medicine formula Pien Tze Huang (PZH) has long been used to treat various malignancies, including colorectal cancer (CRC). It was recently reported that PZH possesses the ability to overcome multidrug resistance in CRC cells. In the present study, a 5-fluorouracil (5-FU) resistant human CRC cell line (HCT-8/5-FU) was used to further evaluate the effect of PZH on chemotherapy (chemo)-resistance and investigate the mechanisms through which this occurs. The results identified that PZH significantly reduced the viability and cell density of HCT-8/5-FU cells in a dose- and time-dependent manner (P<0...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042284/the-synergism-and-attenuation-effect-of-selenium-se-enriched-grifola-frondosa-se-polysaccharide-on-5-fluorouracil-5-fu-in-heps-bearing-mice
#8
Guanghua Mao, Qian Li, Chunmeng Deng, Yaqian Wang, Yangyang Ding, Weijie Zhang, Yao Chen, Ting Zhao, Fengfeng Wei, Liuqing Yang, Xiangyang Wu
Previous study revealed that Se-GP11 could exhibited its antitumor activity by improving the immune functions. 5-Fu, as a chemotherapeutic drugs, can kill many immune cells in addition to tumor cells. Accordingly, the enhanced antitumor and reduced toxicity of Se-GP11 on 5-Fu were estimated in this study. The results demonstrated that Se-GP11 could evidently increase the antitumor activity of 5-Fu. Furthermore, Se-GP11 could enhance the immune functions during the tumor inhibition process of 5-Fu for increasing the cytokines secretion (IL-2 and TNF-α) and immune organs weights...
October 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29039607/downregulation-of-mir-874-3p-promotes-chemotherapeutic-resistance-in-colorectal-cancer-via-inactivation-of-the-hippo-signaling-pathway
#9
Kaiqian Que, Yuanhe Tong, Ganbo Que, Li Li, Hongcheng Lin, Shuai Huang, Ruoyu Wang, Langlang Tang
Overcoming resistance to chemotherapy is an arduous challenge in the treatment of colorectal cancer (CRC), particularly since the underlying molecular mechanisms remain obscure. In the present study, we reported that miR‑874-3p was markedly downregulated in CRC tissues compared with that in adjacent normal colorectal epithelial tissues. Upregulation of miR-874-3p attenuated the chemoresistance of CRC cells to 5-fluorouracil (5-FU) in vitro and in vivo. Conversely, inhibition of miR-874-3p yielded an opposite effect...
October 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039459/bc-02-eradicates-liver-cancer-stem-cells-by-upregulating-the-ros-dependent-dna-damage
#10
Chunhui Dou, Chunyan Fang, Yan Zhao, Xiaoyan Fu, Yufei Zhang, Dongqi Zhu, Huina Wu, Huijie Liu, Jian Zhang, Wenfang Xu, Zhijun Liu, Hongyan Wang, Daqi Li, Xuejian Wang
Cancer stem cells (CSCs) are responsible for chemoresistance, tumor recurrence and metastasis. Reportedly, aminopeptidase N (APN, also known as CD13) is a marker for semi-quiescent CSCs and a therapeutic target in human liver CSCs. In the present study, the effect of BC-02, a compound obtained by conjugating a CD13 inhibitor bestatin and fluorouracil (5-FU), was investigated toward liver CSCs. Tumor spheres formed in serum-free culture conditions have been successfully used to enrich CSCs. In this study, the sphere cells were shown to have several characteristics of CSCs, including drug resistance, high tumorigenicity, epithelial-mesenchymal transition (EMT) phenotype, lower reactive oxygen species (ROS) levels, greater colony-forming efficiency and increased proliferation capacity in vitro...
October 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29039072/first-line-bolus-5-fluorouracil-plus-leucovorin-for-peritoneally-disseminated-gastric-cancer-with-massive-ascites-or-inadequate-oral-intake
#11
Hiroki Hara, Shigenori Kadowaki, Masako Asayama, Akira Ooki, Toko Yamada, Takako Yoshii, Kensei Yamaguchi
BACKGROUND: There are few chemotherapeutic options for advanced gastric cancer with severe disseminated peritoneal metastases, which are usually accompanied by ascites. Bolus 5-fluorouracil (5-FU) plus leucovorin therapy has been widely used against gastrointestinal malignancies, with resulting mild toxicities. METHODS: We retrospectively analyzed the efficacy and safety of first-line chemotherapy with bolus 5-FU plus l-leucovorin in 30 advanced gastric cancer patients who had massive ascites and/or inadequate oral intake...
October 16, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29038417/role-of-exogenous-phosphocreatine-in-chemotherapy-induced-cardiomyopathy
#12
Swapnil Parve, Gulnaz I Aliakberova, Albert A Gylmanov, Diana I Abdulganieva
The 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) regimen is widely used in the management of breast cancer. The common cardiotoxic effects of doxorubicin include congestive heart failure and left ventricular dysfunction, and those of cyclophosphamide include pericarditis, myocarditis, and congestive heart failure. It has been postulated that cardiotoxicity of 5-fluorouracil presents as coronary artery diseases (eg, angina). Cardiomyopathy is a common outcome following treatment with the FAC regimen...
2017: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29037023/simultaneous-integrated-boost-intensity-modulated-radiotherapy-versus-3-dimensional-conformal-radiotherapy-in-preoperative-concurrent-chemoradiotherapy-for-locally-advanced-rectal-cancer
#13
Bong Kyung Bae, Min Kyu Kang, Jae-Chul Kim, Mi Young Kim, Gyu-Seog Choi, Jong Gwang Kim, Byung Woog Kang, Hye Jin Kim, Soo Yeun Park
PURPOSE: To evaluate the feasibility of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) for preoperative concurrent chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC), by comparing with 3-dimensional conformal radiotherapy (3D-CRT). MATERIALS AND METHODS: Patients who were treated with PCRT for LARC from 2015 January to 2016 December were retrospectively enrolled. Total doses of 45 Gy to 50.4 Gy with 3D-CRT or SIB-IMRT were administered concomitantly with 5-fluorouracil plus leucovorin or capecitabine...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29035999/effects-on-18f-fdg-pet-ct-brain-glucose-metabolism-in-rectal-cancer-patients-undergoing-neoadjuvant-chemotherapy
#14
Alexei M C Machado, Theara C Fagundes, Arnoldo Mafra, Rodrigo G Silva, Ana Carolina G Castro, Marcelo Mamede
PURPOSE: Retrospective study of the effects of anticancer treatment on the brain metabolism of patients diagnosed with rectal cancer based on a large and homogeneous sample of 40 paired F-FDG PET/CT volumes taken from 20 patients. The results are compared to the ones presented by related works to help elucidating the mechanisms of neurotoxicity associated to a decrease in memory, learning and motor skills. PATIENTS AND METHODS: Twenty patients with rectal adenocarcinoma were scanned before and after neoadjuvant chemoradiation based exclusively on 5-fluorouracil and leucovorin...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29034831/graphene-oxide-based-metallic-nanoparticles-and-their-some-biological-and-environmental-application
#15
Aftab Aslam Parwaz Khan, Anish Khan, Abdullah M Asiri, Basma Galeb Alhogbia, Ghulam Md Ashraf
Recently the decoration of graphene with metallic nanoparticles by a synchronized reduction of graphene oxide (GO) and synthesis of metallic nanoparticles has gained energy. Metal-decorated carbon substrates, for example, carbon nanotubes and graphene oxide have been of mind boggling excitement to the scientific group all through the past three decades on account of different potential applications.The utilization of graphene oxide as the nano scale substrates for the formation of nanocomposites with metal oxides is a novel thought to acquire a hybrid which would show both the properties of GO as an interesting paper-shape material and the elements of single nano-sized metal particles...
October 16, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29031952/antitumor-efficacy-and-toxicity-of-5-fu-loaded-plga-pellets
#16
Nattawut Leelakanok, Sean M Geary, Aliasger K Salem
The aim of this study was to formulate a biodegradable implant capable of imparting local anti-tumor activity through the sustained release of the chemotherapeutic agent, 5-fluorouracil (5-FU). Thus injectable pellets (< 1.2 mm diameter) made from poly(lactide co-glycolide (PLGA) and loaded with 5-FU at varying drug:polymer ratios were fabricated using hot-melt extrusion and tested for their ability to provide sustained release of 5-FU in in vitro and in vivo settings. In addition, these formulations were compared against soluble 5-FU for their antitumor activity in vivo as well as for their toxicity...
October 12, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29030256/ficus-virens-proanthocyanidins-induced-apoptosis-in-breast-cancer-cells-concomitantly-ameliorated-5-fluorouracil-induced-intestinal-mucositis-in-rats
#17
Xiao-Xin Chen, Kar Ho Lam, Qing-Xi Chen, George Pak-Heng Leung, Sydney Chi Wai Tang, Stephen Cho-Wing Sze, Jian-Bo Xiao, Feng Feng, Ying Wang, Kalin Yan-Bo Zhang, Zhang-Jin Zhang
5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent for breast cancer. However, its use often leads to drug resistance and mucositis. This study aimed to investigate whether proanthocyanidins from Ficus virens possessed anti-breast cancer and anti-mucositis activities. The results showed that the cytotoxic effects of the proanthocyanidins against MDA-MB-231 and MCF-7 breast cancer cells were in the order of stem barks proanthocyanidins (SPAs) > leaves proanthocyanidins > fruits proanthocyanidins...
October 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29028255/wipe-sampling-method-and-evaluation-of-environmental-variables-for-assessing-surface-contamination-of-10-antineoplastic-drugs-by-liquid-chromatography-tandem-mass-spectrometry
#18
Manuel Colombo, Matthew Jeronimo, George Astrakianakis, Chirag Apte, Chun-Yip Hon
This paper describes a novel wipe sampling and high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) method capable of simultaneously detecting 10 antineoplastic drugs (5-fluorouracil, oxaliplatin, methotrexate, vindesine, ifosfamide, cyclophosphamide, vincristine, vinblastine, docetaxel, and paclitaxel). The good overall recoveries and sensitivity values of this method along with the comparatively short run time (8 min) allows for its use in routine monitoring in health care facilities...
October 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29028251/monitoring-surface-contamination-by-antineoplastic-drugs-in-italian-hospitals-performance-based-hygienic-guidance-values-hgvs-project
#19
Cristina Sottani, Elena Grignani, Enrico Oddone, Beatrice Dezza, Sara Negri, Simona Villani, Danilo Cottica
Antineoplastic drugs (ADs) will continue to represent a potential risk for personnel involved in the handling of these compounds and great concerns have been raised by the presence of ADs in many surveyed workplaces. Eight hospitals were investigated by means of wipe sampling for surface residue determination. Each wipe sample was tested for five ADs considered suitable exposure markers. Cyclophosphamide (CP), gemcitabine (GEM), 5-fluorouracil (5-FU), platinum-containing drugs (Pt), and epi-doxorubicin (EPI) contamination levels were measured in 85 per cent of the studied pharmacies and 93 per cent of outpatient care units (OpCUs)...
October 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29023126/lyotropic-liquid-crystalline-nanosystems-as-drug-delivery-agents-for-5-fluorouracil-structure-and-cytotoxicity
#20
Paola Astolfi, Elisabetta Giorgini, Valentina Gambini, Barbara Rossi, Lisa Vaccari, Francesco Vita, Oriano Francescangeli, Cristina Marchini, Michela Pisani
Lyotropic cubic liquid crystalline systems have received increasing attention due to their unique microstructural and physicochemical properties as efficient nanocarriers for drug delivery. In this study we report the preparation and characterization of bulk phases and cubosome dispersions of phytantriol loaded with the anticancer drug 5-fluorouracil, in neutral and anionic forms. In both cases, a Pn3m cubic phase was observed. The phytantriol phase behavior can be influenced by the addition of ionic agents and to this purpose a positively charged lipid, such as N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride salt (DOTAP), was included in the studied formulations...
October 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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