Gian Pietro Serra, Adriane Guillaumin, Bianca Vlcek, Lorena Delgado-Zabalza, Alessia Ricci, Eleonora Rubino, Sylvie Dumas, Jérôme Baufreton, François Georges, Åsa Wallén-Mackenzie
The subthalamic nucleus (STN) is critical for behavioral control; its dysregulation consequently correlated with neurological and neuropsychiatric disorders, including Parkinson's disease. Deep brain stimulation (DBS) targeting the STN successfully alleviates parkinsonian motor symptoms. However, low mood and depression are affective side effects. STN is adjoined with para-STN, associated with appetitive and aversive behavior. DBS aimed at STN might unintentionally modulate para-STN, causing aversion. Alternatively, the STN mediates aversion...
November 4, 2023: Cell Reports