Nicholas D Schiff, Joseph T Giacino, Christopher R Butson, Eun Young Choi, Jonathan L Baker, Kyle P O'Sullivan, Andrew P Janson, Michael Bergin, Helen M Bronte-Stewart, Jason Chua, Laurel DeGeorge, Sureyya Dikmen, Adam Fogarty, Linda M Gerber, Mark Krel, Jose Maldonado, Matthew Radovan, Sudhin A Shah, Jason Su, Nancy Temkin, Thomas Tourdias, Jonathan D Victor, Abigail Waters, Stephanie A Kolakowsky-Hayner, Joseph J Fins, Andre G Machado, Brian K Rutt, Jaimie M Henderson
Converging evidence indicates that impairments in executive function and information-processing speed limit quality of life and social reentry after moderate-to-severe traumatic brain injury (msTBI). These deficits reflect dysfunction of frontostriatal networks for which the central lateral (CL) nucleus of the thalamus is a critical node. The primary objective of this feasibility study was to test the safety and efficacy of deep brain stimulation within the CL and the associated medial dorsal tegmental (CL/DTTm) tract...
December 2023: Nature Medicine