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https://www.readbyqxmd.com/read/28731819/the-close-up-imager-onboard-the-esa-exomars-rover-objectives-description-operations-and-science-validation-activities
#1
Jean-Luc Josset, Frances Westall, Beda A Hofmann, John Spray, Charles Cockell, Stephan Kempe, Andrew D Griffiths, Maria Cristina De Sanctis, Luigi Colangeli, Detlef Koschny, Karl Föllmi, Eric Verrecchia, Larryn Diamond, Marie Josset, Emmanuelle J Javaux, Francesca Esposito, Matthew Gunn, Audrey L Souchon-Leitner, Tomaso R R Bontognali, Oleg Korablev, Suren Erkman, Gerhard Paar, Stephan Ulamec, Frédéric Foucher, Philippe Martin, Antoine Verhaeghe, Mitko Tanevski, Jorge L Vago
The Close-Up Imager (CLUPI) onboard the ESA ExoMars Rover is a powerful high-resolution color camera specifically designed for close-up observations. Its accommodation on the movable drill allows multiple positioning. The science objectives of the instrument are geological characterization of rocks in terms of texture, structure, and color and the search for potential morphological biosignatures. We present the CLUPI science objectives, performance, and technical description, followed by a description of the instrument's planned operations strategy during the mission on Mars...
June 2017: Astrobiology
https://www.readbyqxmd.com/read/28683645/substitution-of-nevirapine-or-raltegravir-for-protease-inhibitor-vs-rosuvastatin-treatment-for-the-management-of-dyslipidaemia-in-hiv-infected-patients-on-stable-antiretroviral-therapy-nevrast-study
#2
Leonardo Calza, Eleonora Magistrelli, Vincenzo Colangeli, Marco Borderi, Linda Bussini, Isabella Bon, Maria Carla Re, Pierluigi Viale
OBJECTIVES: An observational, prospective, cohort study was performed to compare efficacy and safety of a switch from ritonavir-boosted protease inhibitor (PI/r) to nevirapine or raltegravir with that of rosuvastatin addition to current antiretroviral therapy in HIV-infected patients with hyperlipidaemia. METHODS: All HIV-infected patients receiving a stable PI/r-based antiretroviral regimen, with persistently suppressed viremia, naïve to non-nucleoside analogues and to integrase strand transfer inhibitors, with mixed hyperlipidaemia, and who underwent a switch from PI/r to nevirapine (Group A) or raltegravir (Group B) or who started rosuvastatin at 10 mg daily (group C) with unchanged antiretroviral regimen were enrolled into the study...
July 6, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28647290/effect-of-professional-expertise-and-exposure-to-everyday-life-decision-making-on-moral-choices
#3
Maddalena Boccia, Paola Verde, Gregorio Angelino, Paolo Carrozzo, Diego Vecchi, Laura Piccardi, Stefano Colangeli, Pierluigi Cordellieri, Fabio Ferlazzo, Anna Maria Giannini
Moral sense is defined as a feeling of fairness or unfairness of an action that knowingly causes harm to people other than the subject. It is crucial in determining human behavior and becomes pivotal in operational environments. Here we assessed whether professional daily life experience in an operational environment affects moral judgment by asking 41 military pilots of the Italian Air Force (P) and 69 controls (C) to solve 40 moral dilemmas. We found that P gave more morally acceptable utilitarian responses to moral dilemmas...
June 21, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28632329/postictal-hypoperfusion-hypoxia-provides-the-foundation-for-a-unified-theory-of-seizure-induced-brain-abnormalities-and-behavioral-dysfunction
#4
REVIEW
Jordan S Farrell, Roberto Colangeli, Marshal D Wolff, Alexandra K Wall, Thomas J Phillips, Antis George, Paolo Federico, G Campbell Teskey
A recent article by Farrell et al. characterizes the phenomenon, mechanisms, and treatment of a local and severe hypoperfusion/hypoxia event that occurs in brain regions following a focal seizure. Given the well-established role of cerebral ischemia/hypoxia in brain damage and behavioral dysfunction in other clinical settings (e.g., stroke, cerebral vasospasm), we put forward a new theory: postictal hypoperfusion/hypoxia is responsible for the negative consequences associated with seizures. Fortunately, inhibition of two separate molecular targets, cyclooxygenase-2 (COX-2) and l-type calcium channels, can prevent the expression of postictal hypoperfusion/hypoxia...
June 20, 2017: Epilepsia
https://www.readbyqxmd.com/read/28420298/prevalence-of-metabolic-syndrome-in-hiv-infected-patients-naive-to-antiretroviral-therapy-or-receiving-a-first-line-treatment
#5
Leonardo Calza, Vincenzo Colangeli, Eleonora Magistrelli, Nicolo' Rossi, Elena Rosselli Del Turco, Linda Bussini, Marco Borderi, Pierluigi Viale
BACKGROUND: The combination antiretroviral therapy (cART) has dramatically improved the life expectancy of patients with HIV infection, but may lead to several long-term metabolic abnormalities. However, data about the frequency of metabolic syndrome (MS) in HIV-infected people vary considerably across different observational studies. METHODS: The prevalence of MS among HIV-infected patients was evaluated by a cross-sectional study conducted among subjects naive to cART or receiving the first antiretroviral regimen and referring to our Clinics from January 2015 to December 2015...
May 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/28296514/can-unilateral-progressive-or-sudden-hearing-loss-be-immune-mediated-in-origin
#6
Francesca Atturo, Roberta Colangeli, Giorgio Bandiera, Maurizio Barbara, Simonetta Monini
OBJECTIVE: The aim of the present study was to demonstrate that the positivity of nonspecific immunological tests could be found not only in bilateral hearing loss but also in unilateral cases, either sudden or progressive. METHOD: An observational case series study included subjects suffering from unilateral or bilateral, sudden or progressive, symmetric or asymmetric sensorineural hearing loss (SNHL). All the patients underwent pure tone audiometry and the following battery of blood exams: anti-nuclear antibody (ANA), extractable nuclear antigen (ENA) antibody screening, anti-thyroperoxidase (anti-TPO), anti-thyroglobulin and anti-smooth muscle antibody (ASMA)...
March 15, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28116848/plasma-trough-concentrations-of-darunavir-ritonavir-and-raltegravir-in-older-patients-with-hiv-1-infection
#7
L Calza, V Colangeli, E Magistrelli, L Bussini, M Conti, E Ramazzotti, R Mancini, P Viale
OBJECTIVES: The aim of the study was to assess plasma concentrations of darunavir/ritonavir and raltegravir in older patients compared with younger patients with HIV-1 infection. METHODS: In this observational, open-label study, adult HIV-infected out-patients aged ≤ 40 years (younger patients) or ≥ 60 years (older patients) and treated with tenofovir/emtricitabine plus darunavir/ritonavir (800/100 mg daily) or raltegravir (400 mg twice daily) were asked to participate...
January 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28088884/dual-raltegravir-etravirine-combination-as-maintenance-regimen-in-virologically-suppressed-hiv-1-infected-patients
#8
Leonardo Calza, Eleonora Magistrelli, Vincenzo Colangeli, Roberto Manfredi, Marco Borderi, Nicolo' Rossi, Matteo Conti, Rita Mancini, Pierluigi Viale
BACKGROUND: Nucleoside reverse transcriptase inhibitor (NRTI)- and protease inhibitor (PI)-sparing antiretroviral regimens may be useful in selected human immune deficiency virus (HIV)-infected patients with resistance or intolerance to these drug classes. METHODS: This was an observational prospective study of patients on suppressive antiretroviral therapy containing two NRTIs plus one ritonavir-boosted PI who switched to a dual regimen containing raltegravir plus etravirine...
February 16, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28060020/significant-association-between-statin-associated-myalgia-and-vitamin-d-deficiency-among-treated-hiv-infected-patients
#9
Leonardo Calza, Eleonora Magistrelli, Vincenzo Colangeli, Marco Borderi, Ilaria Contadini, Isabella Bon, Maria Carla Re, Pierluigi Viale
BACKGROUND: Several studies have shown a significant association between vitamin D deficiency and an increased risk of statin-related symptomatic myalgia in the general population, but there are no data among HIV-infected persons. METHODS: A retrospective, cohort study was conducted to assess the incidence of symptomatic myalgia and elevation in serum creatine kinase level among HIV-positive adults on combination antiretroviral therapy and treated with atorvastatin or rosuvastatin for at least 12 months between 2011 and 2015 in our outpatient unit...
March 13, 2017: AIDS
https://www.readbyqxmd.com/read/27995558/is-there-benefit-to-free-over-pedicled-vascularized-grafts-in-augmenting-tibial-intercalary-allograft-constructs
#10
COMPARATIVE STUDY
Marco Manfrini, Srimanth Bindiganavile, Ferhat Say, Marco Colangeli, Laura Campanacci, Massimiliano Depaolis, Massimo Ceruso, Davide Donati
BACKGROUND: Intercalary reconstruction of tibial sarcomas with vascularized fibula autografts and massive bone allografts is reliable with predictable long-term results. However, inadequate data exist comparing free and pedicled vascularized fibula autografts in combination with a massive bone allograft in patients undergoing intercalary tibia reconstructions. QUESTIONS/PURPOSES: Among patients undergoing large-segment intercalary allografting, we sought to compare supplemental free vascularized fibular autografts with supplemental pedicled vascularized fibular autografts, in terms of (1) oncologic results, (2) complications associated with surgery, (3) Musculoskeletal Tumor Society (MSTS) scores, and (4) surgical time...
May 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27856846/seasonal-exposure-of-carbon-dioxide-ice-on-the-nucleus-of-comet-67p-churyumov-gerasimenko
#11
G Filacchione, A Raponi, F Capaccioni, M Ciarniello, F Tosi, M T Capria, M C De Sanctis, A Migliorini, G Piccioni, P Cerroni, M A Barucci, S Fornasier, B Schmitt, E Quirico, S Erard, D Bockelee-Morvan, C Leyrat, G Arnold, V Mennella, E Ammannito, G Bellucci, J Benkhoff, J P Bibring, A Blanco, M I Blecka, R Carlson, U Carsenty, L Colangeli, M Combes, M Combi, J Crovisier, P Drossart, T Encrenaz, C Federico, U Fink, S Fonti, M Fulchignoni, W-H Ip, P Irwin, R Jaumann, E Kuehrt, Y Langevin, G Magni, T McCord, L Moroz, S Mottola, E Palomba, U Schade, K Stephan, F Taylor, D Tiphene, G P Tozzi, P Beck, N Biver, L Bonal, J-Ph Combe, D Despan, E Flamini, M Formisano, A Frigeri, D Grassi, M S Gudipati, D Kappel, A Longobardo, F Mancarella, K Markus, F Merlin, R Orosei, G Rinaldi, M Cartacci, A Cicchetti, Y Hello, F Henry, S Jacquinod, J M Reess, R Noschese, R Politi, G Peter
Carbon dioxide (CO2) is one of the most abundant species in cometary nuclei, but because of its high volatility, CO2 ice is generally only found beneath the surface. We report the infrared spectroscopic identification of a CO2 ice-rich surface area located in the Anhur region of comet 67P/Churyumov-Gerasimenko. Spectral modeling shows that about 0.1% of the 80- by 60-meter area is CO2 ice. This exposed ice was observed a short time after the comet exited local winter; following the increased illumination, the CO2 ice completely disappeared over about 3 weeks...
December 23, 2016: Science
https://www.readbyqxmd.com/read/27727402/hiv-1-early-and-late-diagnosis-in-the-emilia-romagna-region-italy-a-three-year-study
#12
Giuseppina Musumeci, Giacomo Magnani, Isabella Bon, Serena Longo, Alessia Bertoldi, Anna Maria Degli Antoni, Maria Rita Rossi, Alessandro Ruggeri, Vittorio Sambri, Simona Semprini, Laura Sighinolfi, Maria Alessandra Ursitti, Alessandro Zerbini, Vincenzo Colangeli, Leonardo Calza, Alba Carola Finarelli, Erika Massimiliani, Maria Carla Re
It is crucial to establish the timing of infection and distinguish between early and long-lasting HIV-1 infections not only for partner notification and epidemiological surveillance, but also to offer early drug treatment and contain the spread of infection. This study analyzed serum and/or plasma samples with a first positive HIV antibody/antigen result coming from different Medical Centers in the Emilia Romagna Region, North East Italy, using the avidity assay, Western Blotting, RNA viral load, CD4 cell counts and genotyping assay...
October 2016: New Microbiologica
https://www.readbyqxmd.com/read/27645694/the-role-of-fdg-pet-ct-in-patients-treated-with-neoadjuvant-chemotherapy-for-localized-bone-sarcomas
#13
RANDOMIZED CONTROLLED TRIAL
Emanuela Palmerini, Marco Colangeli, Cristina Nanni, Stefano Fanti, Emanuela Marchesi, Anna Paioli, Piero Picci, Silvia Cambioli, Davide Donati, Luca Cevolani, Massimiliano De Paolis, Marco Gambarotti, Stefano Ferrari
PURPOSE: The histological response to neoadjuvant chemotherapy is an important prognostic factor in patients with osteosarcoma (OS) and Ewing sarcoma (EWS). The aim of this study was to assess baseline primary tumour FDG uptake on PET/CT, and serum values of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), to establish whether these factors are correlated with tumour necrosis and prognosis. METHODS: Patients treated between 2009 and 2014 for localized EWS and OS, who underwent FDG PET/CT as part of their staging work-up, were included...
February 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27618139/significant-decrease-in-plasma-levels-of-d-dimer-interleukin-8-and-interleukin-12-after-a-12-month-treatment-with-rosuvastatin-in-hiv-infected-patients-under-antiretroviral-therapy
#14
Leonardo Calza, Vincenzo Colangeli, Eleonora Magistrelli, Ilaria Contadini, Isabella Bon, Maria Carla Re, Matteo Conti, Rita Mancini, Pierluigi Viale
OBJECTIVES: Statins have shown anti-inflammatory and immune-modulatory properties in both general and HIV-infected population, but their effect on plasma D-dimer levels is controversial and it has not been investigated to date in HIV-positive patients. The aim of our study was to assess the effect of rosuvastatin on D-dimer and other serum inflammation markers among these subjects. METHODS: Prospective, cohort study of HIV-1-infected adult patients receiving a stable combination antiretroviral therapy (cART), who started a lipid-lowering therapy with rosuvastatin (10 mg daily) and were followed up for at least 12 months...
February 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27602514/high-molecular-weight-organic-matter-in-the-particles-of-comet-67p-churyumov-gerasimenko
#15
Nicolas Fray, Anaïs Bardyn, Hervé Cottin, Kathrin Altwegg, Donia Baklouti, Christelle Briois, Luigi Colangeli, Cécile Engrand, Henning Fischer, Albrecht Glasmachers, Eberhard Grün, Gerhard Haerendel, Hartmut Henkel, Herwig Höfner, Klaus Hornung, Elmar K Jessberger, Andreas Koch, Harald Krüger, Yves Langevin, Harry Lehto, Kirsi Lehto, Léna Le Roy, Sihane Merouane, Paola Modica, François-Régis Orthous-Daunay, John Paquette, François Raulin, Jouni Rynö, Rita Schulz, Johan Silén, Sandra Siljeström, Wolfgang Steiger, Oliver Stenzel, Thomas Stephan, Laurent Thirkell, Roger Thomas, Klaus Torkar, Kurt Varmuza, Karl-Peter Wanczek, Boris Zaprudin, Jochen Kissel, Martin Hilchenbach
The presence of solid carbonaceous matter in cometary dust was established by the detection of elements such as carbon, hydrogen, oxygen and nitrogen in particles from comet 1P/Halley. Such matter is generally thought to have originated in the interstellar medium, but it might have formed in the solar nebula-the cloud of gas and dust that was left over after the Sun formed. This solid carbonaceous material cannot be observed from Earth, so it has eluded unambiguous characterization. Many gaseous organic molecules, however, have been observed; they come mostly from the sublimation of ices at the surface or in the subsurface of cometary nuclei...
October 6, 2016: Nature
https://www.readbyqxmd.com/read/27488863/long-term-treatment-with-thiamine-as-possible-medical-therapy-for-friedreich-ataxia
#16
Antonio Costantini, Tiziana Laureti, Maria Immacolata Pala, Marco Colangeli, Simona Cavalieri, Elisa Pozzi, Alfredo Brusco, Sandro Salvarani, Carlo Serrati, Roberto Fancellu
Thiamine (vitamin B1) is a cofactor of fundamental enzymes of cell energetic metabolism; its deficiency causes disorders affecting both the peripheral and central nervous system. Previous studies reported low thiamine levels in cerebrospinal fluid and pyruvate dehydrogenase dysfunction in Friedreich ataxia (FRDA). We investigated the effect of long-term treatment with thiamine in FRDA, evaluating changes in neurological symptoms, echocardiographic parameters, and plasma FXN mRNA levels. Thirty-four consecutive FRDA patients have been continuously treated with intramuscular thiamine 100 mg twice a week and have been assessed with the Scale for the Assessment and Rating of Ataxia (SARA) at baseline, after 1 month, and then every 3 months during treatment...
November 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27427539/a-case-of-symmetrical-lipomatosis-of-the-tongue-presenting-as-macroglossia
#17
Maria Giulia Cristofaro, Walter Colangeli, Umberto Riccelli, Mario Giudice
UNLABELLED: Lipomas are the most common benign soft tissue mesenchymal tumours composed of mature adipose tissue. They are uncommon in the oral and maxillofacial regions, with 15-20 % of cases involving the head and neck region and less than 5% of all benign oral lesions. Multiple symmetric lipomatosis is rare and characterized by diffuse growth and nonencapsulated lipomas. It is usually found in the posterior neck and upper trunk and they are relatively infrequent on the oral and maxillofacial regions like Madelung disease...
June 18, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27427502/effects-of-cold-therapy-in-the-treatment-of-mandibular-angle-fractures-hilotherm-system-vs-ice-bag
#18
Ida Barca, Walter Colangeli, Maria Giulia Cristofaro, Amerigo Giudice, Elio Giofrè, Anna Varano, Mario Giudice
AIM: To evaluate the effectiveness of Hilotherm, a recently introduced cooling system, in controlling postoperative edema and pain and to compare the results with those obtained with conventional cryotherapy. MATERIAL OF STUDY: The investigators selected 40 patients with unilateral angle fracture of the jaw and divided them into two groups, cryotherapy with ice bag (A group), and Hilotherapy system (B Group); both groups with the same drug treatment. Facial swelling was preoperatively quantified measuring skin segments (called α, β, γ and δ), pain and patient satisfaction were measured for each with questionnaires...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27351983/rehabilitation-needs-in-oncological-patients-the-on-rehab-project-results-on-patients-operated-for-musculoskeletal-tumors
#19
Maria G Benedetti, Silayan Erfe Delayon, Marco Colangeli, Federica Parisini, Stefano Ferrari, Marco Manfrini, Isabella Springhetti
BACKGROUND: Rehabilitation plays an important role in improving functional outcome in patients operated on musculoskeletal tumors. Literature in the field is scarce and the specific needs for rehabilitation of these patients are still unknown. AIM: To analyze the rehabilitation needs of patients with primary malignant musculoskeletal tumors. DESIGN: Observational, longitudinal study on both inpatient and outpatient operated on musculoskeletal tumors...
February 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27307143/cognitive-reserve-in-healthy-aging-and-alzheimer-s-disease-a-meta-analysis-of-fmri-studies
#20
Stefano Colangeli, Maddalena Boccia, Paola Verde, Paola Guariglia, Filippo Bianchini, Laura Piccardi
Cognitive reserve (CR) has been defined as the ability to optimize or maximize performance through differential recruitment of brain networks. In the present study, we aimed at providing evidence for a consistent brain network underpinning CR in healthy and pathological aging. To pursue this aim, we performed a coordinate-based meta-analysis of 17 functional magnetic resonance imaging studies on CR proxies in healthy aging, Alzheimer's disease (AD), and mild cognitive impairment (MCI). We found that different brain areas were associated with CR proxies in healthy and pathological aging...
August 2016: American Journal of Alzheimer's Disease and Other Dementias
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