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Giuseppina Musumeci, Giacomo Magnani, Isabella Bon, Serena Longo, Alessia Bertoldi, Anna Maria Degli Antoni, Maria Rita Rossi, Alessandro Ruggeri, Vittorio Sambri, Simona Semprini, Laura Sighinolfi, Maria Alessandra Ursitti, Alessandro Zerbini, Vincenzo Colangeli, Leonardo Calza, Alba Carola Finarelli, Erika Massimiliani, Maria Carla Re
It is crucial to establish the timing of infection and distinguish between early and long-lasting HIV-1 infections not only for partner notification and epidemiological surveillance, but also to offer early drug treatment and contain the spread of infection. This study analyzed serum and/or plasma samples with a first positive HIV antibody/antigen result coming from different Medical Centers in the Emilia Romagna Region, North East Italy, using the avidity assay, Western Blotting, RNA viral load, CD4 cell counts and genotyping assay...
September 13, 2016: New Microbiologica
Emanuela Palmerini, Marco Colangeli, Cristina Nanni, Stefano Fanti, Emanuela Marchesi, Anna Paioli, Piero Picci, Silvia Cambioli, Davide Donati, Luca Cevolani, Massimiliano De Paolis, Marco Gambarotti, Stefano Ferrari
PURPOSE: The histological response to neoadjuvant chemotherapy is an important prognostic factor in patients with osteosarcoma (OS) and Ewing sarcoma (EWS). The aim of this study was to assess baseline primary tumour FDG uptake on PET/CT, and serum values of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), to establish whether these factors are correlated with tumour necrosis and prognosis. METHODS: Patients treated between 2009 and 2014 for localized EWS and OS, who underwent FDG PET/CT as part of their staging work-up, were included...
September 20, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Leonardo Calza, Vincenzo Colangeli, Eleonora Magistrelli, Ilaria Contadini, Isabella Bon, Maria Carla Re, Matteo Conti, Rita Mancini, Pierluigi Viale
OBJECTIVES: Statins have shown anti-inflammatory and immune-modulatory properties in both general and HIV-infected population, but their effect on plasma D-dimer levels is controversial and it has not been investigated to date in HIV-positive patients. The aim of our study was to assess the effect of rosuvastatin on D-dimer and other serum inflammation markers among these subjects. METHODS: Prospective, cohort study of HIV-1-infected adult patients receiving a stable combination antiretroviral therapy (cART), who started a lipid-lowering therapy with rosuvastatin (10 mg daily) and were followed up for at least 12 months...
October 14, 2016: AIDS Research and Human Retroviruses
Nicolas Fray, Anaïs Bardyn, Hervé Cottin, Kathrin Altwegg, Donia Baklouti, Christelle Briois, Luigi Colangeli, Cécile Engrand, Henning Fischer, Albrecht Glasmachers, Eberhard Grün, Gerhard Haerendel, Hartmut Henkel, Herwig Höfner, Klaus Hornung, Elmar K Jessberger, Andreas Koch, Harald Krüger, Yves Langevin, Harry Lehto, Kirsi Lehto, Léna Le Roy, Sihane Merouane, Paola Modica, François-Régis Orthous-Daunay, John Paquette, François Raulin, Jouni Rynö, Rita Schulz, Johan Silén, Sandra Siljeström, Wolfgang Steiger, Oliver Stenzel, Thomas Stephan, Laurent Thirkell, Roger Thomas, Klaus Torkar, Kurt Varmuza, Karl-Peter Wanczek, Boris Zaprudin, Jochen Kissel, Martin Hilchenbach
The presence of solid carbonaceous matter in cometary dust was established by the detection of elements such as carbon, hydrogen, oxygen and nitrogen in particles from comet 1P/Halley. Such matter is generally thought to have originated in the interstellar medium, but it might have formed in the solar nebula-the cloud of gas and dust that was left over after the Sun formed. This solid carbonaceous material cannot be observed from Earth, so it has eluded unambiguous characterization. Many gaseous organic molecules, however, have been observed; they come mostly from the sublimation of ices at the surface or in the subsurface of cometary nuclei...
September 7, 2016: Nature
Antonio Costantini, Tiziana Laureti, Maria Immacolata Pala, Marco Colangeli, Simona Cavalieri, Elisa Pozzi, Alfredo Brusco, Sandro Salvarani, Carlo Serrati, Roberto Fancellu
Thiamine (vitamin B1) is a cofactor of fundamental enzymes of cell energetic metabolism; its deficiency causes disorders affecting both the peripheral and central nervous system. Previous studies reported low thiamine levels in cerebrospinal fluid and pyruvate dehydrogenase dysfunction in Friedreich ataxia (FRDA). We investigated the effect of long-term treatment with thiamine in FRDA, evaluating changes in neurological symptoms, echocardiographic parameters, and plasma FXN mRNA levels. Thirty-four consecutive FRDA patients have been continuously treated with intramuscular thiamine 100 mg twice a week and have been assessed with the Scale for the Assessment and Rating of Ataxia (SARA) at baseline, after 1 month, and then every 3 months during treatment...
November 2016: Journal of Neurology
Maria Giulia Cristofaro, Walter Colangeli, Umberto Riccelli, Mario Giudice
UNLABELLED: Lipomas are the most common benign soft tissue mesenchymal tumours composed of mature adipose tissue. They are uncommon in the oral and maxillofacial regions, with 15-20 % of cases involving the head and neck region and less than 5% of all benign oral lesions. Multiple symmetric lipomatosis is rare and characterized by diffuse growth and nonencapsulated lipomas. It is usually found in the posterior neck and upper trunk and they are relatively infrequent on the oral and maxillofacial regions like Madelung disease...
2016: Annali Italiani di Chirurgia
Ida Barca, Walter Colangeli, Maria Giulia Cristofaro, Amerigo Giudice, Elio Giofrè, Anna Varano, Mario Giudice
AIM: To evaluate the effectiveness of Hilotherm, a recently introduced cooling system, in controlling postoperative edema and pain and to compare the results with those obtained with conventional cryotherapy. MATERIAL OF STUDY: The investigators selected 40 patients with unilateral angle fracture of the jaw and divided them into two groups, cryotherapy with ice bag (A group), and Hilotherapy system (B Group); both groups with the same drug treatment. Facial swelling was preoperatively quantified measuring skin segments (called α, β, γ and δ), pain and patient satisfaction were measured for each with questionnaires...
June 18, 2016: Annali Italiani di Chirurgia
Maria G Benedetti, Silayan Erfe Delayon, Marco Colangeli, Federica Parisini, Stefano Ferrari, Marco Manfrini, Isabella Springhetti
BACKGROUND: Rehabilitation plays an important role in improving functional outcome in patients operated on musculoskeletal tumors. Literature in the field is scarce and the specific needs for rehabilitation of these patients are still unknown. AIM: To analyze the rehabilitation needs of patients with primary malignant musculoskeletal tumours. DESIGN: Observational, longitudinal study on both inpatient and outpatient operated on musculoskeletal tumours...
June 28, 2016: European Journal of Physical and Rehabilitation Medicine
Stefano Colangeli, Maddalena Boccia, Paola Verde, Paola Guariglia, Filippo Bianchini, Laura Piccardi
Cognitive reserve (CR) has been defined as the ability to optimize or maximize performance through differential recruitment of brain networks. In the present study, we aimed at providing evidence for a consistent brain network underpinning CR in healthy and pathological aging. To pursue this aim, we performed a coordinate-based meta-analysis of 17 functional magnetic resonance imaging studies on CR proxies in healthy aging, Alzheimer's disease (AD), and mild cognitive impairment (MCI). We found that different brain areas were associated with CR proxies in healthy and pathological aging...
August 2016: American Journal of Alzheimer's Disease and Other Dementias
Paola Verde, Maddalena Boccia, Stefano Colangeli, Sonia Barbetti, Raffaella Nori, Fabio Ferlazzo, Francesco Piccolo, Roberto Vitalone, Elena Lucertini, Laura Piccardi
INTRODUCTION: Human navigation is a very complex ability that encompasses all four stages of human information processing (sensory input, perception/cognition, selection, and execution of an action), involving both cognitive and physical requirements. During flight, the pilot uses all of these stages and one of the most critical aspect is interference. In fact, spatial tasks competing for the same cognitive resource cause greater distraction from a concurrent task than another task that uses different resource modalities...
June 2016: Aerospace Medicine and Human Performance
L Calza, V Colangeli, E Magistrelli, R Manfredi, I Bon, M C Re, P Viale
OBJECTIVES: Recent clinical studies and one meta-analysis have shown a modest but significant increase in the incidence of diabetes mellitus associated with statin exposure, so this correlation was investigated in a cohort of HIV-positive subjects. METHODS: A retrospective cohort study including adult HIV-1-infected patients followed at our Clinic of Infectious Diseases between 2007 and 2014 was performed. RESULTS: We assessed 3170 HIV-positive patients with a median follow-up of 5...
September 2016: HIV Medicine
A Norcini Pala, P Steca, R Bagrodia, L Helpman, V Colangeli, P Viale, M L Wainberg
Depressive symptoms cause major impairment and may accelerate HIV progression despite the use of antiretroviral medication. The somatic symptoms criteria for HIV infection and depression partially overlap, which can make differential diagnosis challenging. Because of chronic inflammation caused by HIV infection, HIV-positive patients may develop somatic and affective-cognitive symptoms of depression. Inflammation-related depression is primarily characterized with severe somatic symptoms such as fatigue and sleep disturbance...
August 2016: Brain, Behavior, and Immunity
Leonardo Calza, Vincenzo Colangeli, Roberto Manfredi, Isabella Bon, Maria Carla Re, Pierluigi Viale
The introduction of potent combination antiretroviral therapy (cART) has had a remarkable impact on the natural history of HIV infection, leading to a dramatic decline in the mortality rate and a considerable increase in the life expectancy of HIV-positive people. However, cART use is frequently associated with several metabolic complications, mostly represented by lipid metabolism alterations, which are reported very frequently among persons treated with antiretroviral agents. In particular, hyperlipidaemia occurs in up to 70%-80% of HIV-positive subjects receiving cART and is mainly associated with specific antiretroviral drugs belonging to three classes of antiretroviral agents: NRTIs, NNRTIs and PIs...
June 2016: Journal of Antimicrobial Chemotherapy
G Filacchione, M C De Sanctis, F Capaccioni, A Raponi, F Tosi, M Ciarniello, P Cerroni, G Piccioni, M T Capria, E Palomba, G Bellucci, S Erard, D Bockelee-Morvan, C Leyrat, G Arnold, M A Barucci, M Fulchignoni, B Schmitt, E Quirico, R Jaumann, K Stephan, A Longobardo, V Mennella, A Migliorini, E Ammannito, J Benkhoff, J P Bibring, A Blanco, M I Blecka, R Carlson, U Carsenty, L Colangeli, M Combes, M Combi, J Crovisier, P Drossart, T Encrenaz, C Federico, U Fink, S Fonti, W H Ip, P Irwin, E Kuehrt, Y Langevin, G Magni, T McCord, L Moroz, S Mottola, V Orofino, U Schade, F Taylor, D Tiphene, G P Tozzi, P Beck, N Biver, L Bonal, J-Ph Combe, D Despan, E Flamini, M Formisano, S Fornasier, A Frigeri, D Grassi, M S Gudipati, D Kappel, F Mancarella, K Markus, F Merlin, R Orosei, G Rinaldi, M Cartacci, A Cicchetti, S Giuppi, Y Hello, F Henry, S Jacquinod, J M Reess, R Noschese, R Politi, G Peter
Although water vapour is the main species observed in the coma of comet 67P/Churyumov-Gerasimenko and water is the major constituent of cometary nuclei, limited evidence for exposed water-ice regions on the surface of the nucleus has been found so far. The absence of large regions of exposed water ice seems a common finding on the surfaces of many of the comets observed so far. The nucleus of 67P/Churyumov-Gerasimenko appears to be fairly uniformly coated with dark, dehydrated, refractory and organic-rich material...
January 21, 2016: Nature
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