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https://www.readbyqxmd.com/read/28623897/altered-somatosensory-profile-according-to-quantitative-sensory-testing-in-patients-with-degenerative-lumbar-spine-disorders-scheduled-for-surgery
#1
Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Björn Gerdle, Allan Abbott, Birgitta Öberg
BACKGROUND: Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes, in patients with degenerative lumbar spine disorders pre-surgery. The aim was to describe somatosensory profiles in patients with degenerative lumbar spine disorders, to identify the proportion with altered somatosensory profile, and to analyze demographic characteristics, self-reported function, pain, and health pre- and 3 months post-surgery...
June 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28614190/non-histaminergic-and-mechanical-itch-sensitization-in-atopic-dermatitis
#2
H H Andersen, J Elberling, H Sølvsten, G Yosipovitch, L Arendt-Nielsen
Chronic or episodic severe itch is recurrent in atopic dermatitis (AD). Non-histaminergic neuronal itch pathways are suggested to dominate in AD itch, contributing to an "itch-scratch-itch cycle" that prolongs and worsens itch, pain, and skin lesions. We hypothesized that non-histaminergic neuronal sensitization contributes to itch in AD. Hence, we compared sensitivity to thermal, mechanical, and chemical pruritic stimuli in AD patients and controls. The study comprised 25 AD patients with chronic itch and 25 healthy controls...
June 9, 2017: Pain
https://www.readbyqxmd.com/read/28602692/psychological-characteristics-and-pain-frequency-are-associated-with-experimental-pain-sensitivity-in-pediatric-patients-with-sickle-cell-disease
#3
Nitya Bakshi, Ines Lukombo, Helen Shnol, Inna Belfer, Lakshmanan Krishnamurti
Sickle Cell Disease (SCD) is associated with episodes of severe vasocclusive pain beginning in infancy with a subset of patients with SCD transitioning to chronic pain. Response to experimental pain using Quantitative Sensory Testing (QST) in these patients suggest altered pain processing. The objectives of this study were to characterize sensitivity to multiple modalities of experimental pain stimuli and to interrogate the relationship of psychological covariates, clinical pain burden and pain-related outcomes to experimental pain sensitivity in children with SCD as compared to healthy individuals of similar age and sex...
June 5, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28579822/quantitative-sensory-testing-measures-individual-pain-responses-in-emergency-department-patients
#4
Kevin J Duffy, Katharyn L Flickinger, Jeffrey T Kristan, Melissa J Repine, Alexandro Gianforcaro, Rebecca B Hasley, Saad Feroz, Jessica M Rupp, Jumana Al-Baghli, Maria L Pacella, Brian P Suffoletto, Clifton W Callaway
BACKGROUND: Refining and individualizing treatment of acute pain in the emergency department (ED) is a high priority, given that painful complaints are the most common reasons for ED visits. Few tools exist to objectively measure pain perception in the ED setting. We speculated that variation in perception of fixed painful stimuli would explain individual variation in reported pain and response to treatment among ED patients. MATERIALS AND METHODS: In three studies, we 1) describe performance characteristics of brief quantitative sensory testing (QST) in 50 healthy volunteers, 2) test effects of 10 mg oxycodone versus placebo on QST measures in 18 healthy volunteers, and 3) measure interindividual differences in nociception and treatment responses in 198 ED patients with a painful complaint during ED treatment...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28575334/characterization-of-peripheral-and-central-sensitization-after-dorsal-root-ganglion-intervention-in-patients-with-unilateral-lumbosacral-radicular-pain-a-prospective-pilot-study
#5
V Mehta, S Snidvongs, B Ghai, R Langford, T Wodehouse
Background.: Quantitative sensory testing (QST) has been used to predict the outcome of epidural steroid injections in lumbosacral radicular pain and has the potential to be an important tool in the selection of appropriate treatment (such as epidural steroid injections vs surgery) for patients with chronic radicular pain. In addition, QST assists in identification of the pain pathways of peripheral and central sensitization in selected groups of patients. Methods.: Twenty-three patients were given dorsal root ganglion (DRG) infiltration with local anaesthesia and steroid ('DRG block'), and those who demonstrated at least 50% pain relief were offered pulsed radiofrequency (PRF) to the DRG...
June 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28556476/neurophysiological-changes-associated-with-implant-associated-augmentation-procedures-in-the-lower-jaw
#6
Amely Hartmann, Claudia Welte-Jzyk, Marcus Seiler, Monika Daubländer
BACKGROUND: Neurophysiological changes after oral and maxillofacial surgery remain one of the topics of current research. PURPOSE: This study evaluated if implant placement associated with augmentation procedures increases the possibility of sensory disturbances or result in impaired quality of life during the healing period. MATERIAL AND METHODS: Patients who had obtained an implant placement in the lower jaw in combination with augmentation procedures were examined by implementing a comprehensive Quantitative Sensory Testing (QST) protocol for extra- and intraoral use...
May 29, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28556279/porous-aromatic-framework-as-an-efficient-metal-free-electro-catalyst-for-non-enzymatic-h2o2-sensing
#7
Yuan Rongrong, Gu Yue, Ren Hao, Liu Jia, Zhu Guangshan
A porous aromatic framework (referred as PAF-39) based on tetrakis(4-(9H-carbazol-9-yl)phenyl)methane has been designed and synthesized via oxidative coupling polymerization. PAF-39 exhibits high surface area and high heat of adsorption (Qst) of CO2. Especially, PAF materials was first applied for non-enzymatic H2O2 sensing.
May 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28538207/association-of-serum-ninjurin2-levels-with-neurologic-damage-and-postherpetic-neuralgia-occurrence-an-observational-cohort-study-in-chinese-herpeszoster-patients
#8
Guozhuan Zhang, Yingjiao Sun, Lei Wang, Hui Tian, Lishuang Liang
OBJECTIVES: Postherpetic neuralgia(PHN) is the most common complication of herpeszoster (HZ) infection. The study aimed to explore whether serum Ninjurin2 (for nerve injury-induced protein 2, NINJ2), a novel neurologic damage related protein, is associated with nerve injury and the occurrence of PHN. RESULTS: Seventy-four of the eighty patients completed the study. On the 7th day of AHN, the patients had significantly higher values of NINJ2, cold-sense dispersion (ΔCS), warm-sense dispersion (ΔWS), cold-pain dispersion (ΔCP), heat-pain dispersion (ΔHP) and NRS score compared to controls...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28535551/angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-modulate-the-function-of-myelinated-fibers-after-chemotherapy-a-quantitative-sensory-testing-study
#9
Carlos J Roldan, Juhee Song, Mitchell P Engle, Patrick M Dougherty
BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) have sufficient scientific support for their use as tissue protectors. Preliminary studies suggest that their angiotensin-II type 2 receptor (AT2R)-blocking properties have a beneficial profile in the treatment of neuropathic pain. OBJECTIVES: The purpose of the current study was to quantify the extent of the somatosensory effects of ACEI and ARB in cancer patients with chemotherapy-induced peripheral neuropathy...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28528759/replicate-effects-and-test-retest-reliability-of-quantitative-sensory-threshold-testing-in-dogs-with-and-without-chronic-pain
#10
David Knazovicky, Erika S Helgeson, Beth Case, Andrea Thomson, Margaret E Gruen, William Maixner, B Duncan X Lascelles
OBJECTIVE: To evaluate replicate effects and test-retest reliability of mechanical and thermal quantitative sensory testing (QST) in normal dogs and dogs with osteoarthritis (OA)-associated pain. STUDY DESIGN: A prospective clinical study. ANIMALS: A total of 54 client owned dogs (OA, n=31; controls, n=23). METHODS: Mechanical [electronic von Frey (EVF) and blunt pressure] and thermal (hot and cold) sensory thresholds were obtained in dogs with OA-associated pain and control dogs at two visits, 7 days apart, to assess test-retest reliability...
January 10, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28507594/pain-threshold-reflects-psychological-traits-in-patients-with-chronic-pain-a-cross-sectional-study
#11
Fumie Kato, Tetsuya Abe, Kenji Kanbara, Ikumi Ban, Tadashi Kiba, Sadanobu Kawashima, Yukie Saka, Yasuyuki Mizuno, Mikihiko Fukunaga
BACKGROUND: Chronic pain enhances sensory sensitivity and induces the biased development of psychological traits such as depression and pain catastrophizing, leading to the formation of heterogeneous conditions. Fluctuations in the sensory-related thresholds of non-injured sites (with normal peripheral tissue) in patients with chronic pain are thought to be related to central sensitization. The objectives of this study were to analyze the association between pain tolerance thresholds (PTTs) in non-injured sites and the psychological traits of patients with chronic pain and to evaluate the usefulness of PTT measures in assessments of pathological conditions related to chronic pain...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/28502878/the-relationship-between-sensory-loss-and-persistent-pain-1-year-after-breast-cancer-surgery
#12
Kenneth Geving Andersen, Helle Molter Duriaud, Henrik Kehlet, Eske Kvanner Aasvang
Moderate-to-severe persistent pain after breast cancer surgery (PPBCS) affects 10-20% of the patients. Sensory dysfunction is often concomitantly present suggesting a neuropathic pain state. The relationship between various postoperative pain states and sensory dysfunction has been examined by quantitative sensory testing (QST), but only 2 smaller studies have examined PPBCS and sensory dysfunction in the surgical area. The purpose of this prospective study was to assess the relative importance of sensory function and PPBCS...
May 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28498991/population-differentiation-in-common-walnut-juglans-regia-l-across-major-parts-of-its-native-range-insights-from-molecular-and-morphometric-data
#13
Wladimir Roor, Heino Konrad, Davletbek Mamadjanov, Thomas Geburek
Juglans regia is an economically highly important species for fruit and wood production in the warm temperate and subtropical zones of the Northern Hemisphere. Besides the natural influence of climatic and geomorphological barriers, its genetic structure has been strongly modified by humans and the population history is still unclear. For this reason, we investigated mainly natural walnut populations across the Eurasian continent on a molecular (44 populations, 581 trees) and morphometric level (23 populations, 1391 ripe nuts)...
June 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28493519/neurotransmitters-behind-pain-relief-with-transcranial-magnetic-stimulation-positron-emission-tomography-evidence-for-release-of-endogenous-opioids
#14
S Lamusuo, J Hirvonen, P Lindholm, I K Martikainen, N Hagelberg, R Parkkola, T Taiminen, J Hietala, S Helin, A Virtanen, A Pertovaara, S K Jääskeläinen
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) at M1/S1 cortex has been shown to alleviate neuropathic pain. OBJECTIVES: To investigate the possible neurobiological correlates of cortical neurostimulation for the pain relief. METHODS: We studied the effects of M1/S1 rTMS on nociception, brain dopamine D2 and μ-opioid receptors using a randomized, sham-controlled, double-blinded crossover study design and 3D-positron emission tomography (PET)...
May 11, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28468842/novel-mutations-in-dystonin-provide-clues-to-the-pathomechanisms-of-hsan-vi
#15
Fiore Manganelli, Silvia Parisi, Maria Nolano, Feifei Tao, Simona Paladino, Chiara Pisciotta, Stefano Tozza, Claudia Nesti, Adriana P Rebelo, Vincenzo Provitera, Filippo M Santorelli, Michael E Shy, Tommaso Russo, Stephan Zuchner, Lucio Santoro
OBJECTIVE: To describe a second hereditary sensory autonomic neuropathy type VI (HSAN-VI) family harboring 2 novel heterozygous mutations in the dystonin (DST) gene and to evaluate their effect on neurons derived from induced pluripotent stem cells (iPSC). METHODS: The family consisted of 3 affected siblings from nonconsanguineous healthy parents. All members underwent clinical and electrophysiologic evaluation and genetic analysis. Two patients underwent quantitative sensory testing (QST), cardiovascular reflexes, dynamic sweat test, and skin biopsy to evaluate somatic and autonomic cutaneous innervation and to get fibroblast cultures for developing iPSC-derived neurons...
May 30, 2017: Neurology
https://www.readbyqxmd.com/read/28440002/differential-effect-of-incobotulinumtoxin-a-on-pain-neurogenic-flare-and-hyperalgesia-in-human-surrogate-models-of-neurogenic-pain
#16
S A Diener, M Breimhorst, Th Vogt, H H Krämer, P D Drummond, C Geber, F Birklein
BACKGROUND: The effectiveness of Botulinum-neurotoxin A (BoNT/A) to treat pain in human pain models is very divergent. This study was conducted to clarify if the pain models or the route of BoNT/A application might be responsible for these divergent findings. METHODS: Sixteen healthy subjects (8 males, mean age 27 ± 5 years) were included in a first set of experiments consisting of three visits: (1) Visit: Quantitative sensory testing (QST) was performed before and after intradermal capsaicin injection (CAPS, 15 μg) on one thigh and electrical current stimulation (ES, 1 Hz) on the contralateral thigh...
April 25, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28437846/pain-sensitization-is-associated-with-disease-activity-in-rheumatoid-arthritis-patients-a-cross-sectional-study
#17
Yvonne C Lee, Clifton O Bingham, Robert R Edwards, Wendy Marder, Phillips Kristine, Marcy B Bolster, Daniel J Clauw, Larry W Moreland, Bing Lu, Alyssa Wohlfahrt, Zhi Zhang, Tuhina Neogi
OBJECTIVE: Pain sensitization may contribute to pain severity in rheumatoid arthritis (RA), impacting assessment of disease activity. We examined whether pain processing mechanisms were associated with disease activity among RA patients with active disease. METHODS: This study includes 139 subjects enrolled in the Central Pain in Rheumatoid Arthritis cohort. Subjects underwent quantitative sensory testing (QST), including assessment of pressure pain thresholds (PPTs) at multiple sites, conditioned pain modulation, and temporal summation...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28437509/thermal-perception-as-a-key-factor-for-assessing-effects-of-trigeminal-nerve-injury
#18
Hye-Kyoung Kim, Ki-Suk Kim, Mee-Eun Kim
AIMS: To conduct a functional examination using multimodal exploration of a sample of patients with iatrogenic trigeminal nerve injury to understand the underlying mechanisms of neuropathic pain following trigeminal nerve injury. METHODS: Subjective and objective symptoms and responses to thermal and electrical quantitative sensory testing (QST) were evaluated in 85 patients with unilateral trigeminal nerve injury. Objective symptoms were measured by seven clinical sensory tests...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28437507/effects-of-experimental-pain-and-lidocaine-on-mechanical-somatosensory-profile-and-face-perception
#19
Yuri Martins Costa, Eduardo E Castrillon, Leonardo Rigoldi Bonjardim, Paulo César Rodrigues Conti, Lene Baad-Hansen, Peter Svensson
AIMS: To assess the effects of experimental muscle pain and topical lidocaine applied to the skin overlying the masseter muscle on the mechanical somatosensory profile and face perception of the masseter muscle in healthy participants. METHODS: A total of 28 healthy participants received a 45-minute application of a lidocaine or placebo patch to the skin overlying the masseter muscle followed by one injection of 0.2 mL sterile solution of monosodium glutamate. Measurements were taken four times during each session of quantitative sensory testing (QST) (T0 = baseline, T1 = 45 minutes after patch application, T2 = immediately after glutamate injection, and T3 = 25 minutes after the glutamate injection), and the following variables were measured: mechanical detection threshold (MDT), mechanical pain threshold (MPT), pressure pain threshold (PPT), pain report (pain on palpation, pain spreading on palpation, and pain intensity), pain drawing, and perceptual distortion...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28403113/incidence-of-persistent-postoperative-pain-after-hepatectomies-with-2-regimes-of-perioperative-analgesia-containing-ketamine
#20
COMPARATIVE STUDY
Paula Masgoret, Carmen Gomar, Beatriz Tena, Pilar Taurá, José Ríos, Miquel Coca
Studies designed to assess persistent postoperative pain (PPP) incidence after hepatectomies are lacking. Our aim was to assess PPP incidence 6 months after hepatectomies with intravenous (IV) or epidural (EPI) analgesia containing ketamine.Prospective observational comparative study between 2 cohorts of patients submitted to hepatectomy. Patients received 1 of 2 analgesic regimes containing ketamine: EPI group or IV group. Visual analog scale (VAS), Neuropathic Pain Symptom Inventory (NPSI), Pain Catastrophizing Scale (PCS), and quantitative sensorial testing (QST: to determine area of hyperalgesia/allodynia) were assessed preoperatively and postoperatively at 2 h, 24 h, 7 days, 1 month, and 6 months...
April 2017: Medicine (Baltimore)
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