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https://www.readbyqxmd.com/read/28340251/thermal-qst-phenotypes-associated-with-response-to-lumbar-epidural-steroid-injections-a-pilot-study
#1
Dermot P Maher, Weihua Ding, Sarabdeep Singh, Arissa Opalacz, Claire Fishman, Mary Houghton, Shihab Ahmed, Lucy Chen, Jianren Mao, Yi Zhang
Objective.:  Response to lumbar epidural steroid injection in lumbar radicular pain varies. The purpose of this study is to characterize the changes in quantitative sensory testing (QST) phenotypes of subjects and compare the QST characteristics in patients who do respond to treatment of radicular pain with a lumbar epidural steroid injection (ESI). Design.:  Prospective, observational pilot study. Setting.:  Outpatient pain center. Methods...
March 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28330489/profiling-intraoral-neuropathic-disturbances-following-lingual-nerve-injury-and-in-burning-mouth-syndrome
#2
Amely Hartmann, Robin Seeberger, Malte Bittner, Roman Rolke, Claudia Welte-Jzyk, Monika Daubländer
BACKGROUND: The aim of the study was to analyse intraoral neurophysiological changes in patients with unilateral lingual nerve lesions as well as patients with Burning Mouth Syndrome (BMS) by applying a standardized Quantitative Sensory Testing (QST) protocol. METHODS: The study included patients suffering from a peripheral lesion of the lingual nerve (n = 4), from BMS (n = 5) and healthy controls (n = 8). Neurophysiological tests were performed in the innervation areas of the tongue bilaterally...
March 23, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28328574/the-long-term-reliability-of-static-and-dynamic-quantitative-sensory-testing-in-healthy-individuals
#3
Anna Marcuzzi, Paul J Wrigley, Catherine M Dean, Roger Adams, Julia M Hush
Quantitative sensory tests (QST) have been increasingly used to investigate alterations in somatosensory function in a wide range of painful conditions. The interpretation of these findings is based on the assumption that the measures are stable and reproducible. To date, reliability of QST has been investigated for short test-retest intervals. The aim of this study was to investigate the long-term reliability of a multimodal QST assessment in healthy people, with testing conducted on three occasions over 4-months...
March 21, 2017: Pain
https://www.readbyqxmd.com/read/28302148/thermal-quantitative-sensory-testing-in-healthy-dutch-children-and-adolescents-standardized-test-paradigm-and-dutch-reference-values
#4
Gerbrich E van den Bosch, Monique van Dijk, Dick Tibboel, Abraham J Valkenburg
BACKGROUND: Quantitative sensory testing (QST) is often used to measure children's and adults' detection- and pain thresholds in a quantitative manner. In children especially the Thermal Sensory Analyzer (TSA-II) is often applied to determine thermal detection and pain thresholds. As comparisons between studies are hampered by the different testing protocols used, we aimed to present a standard protocol and reference values for thermal detection- and pain thresholds in children. METHODS: Our standard testing protocol includes reaction time dependent and independent tests and takes about 14-18 min to complete...
March 16, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28301464/investigating-the-case-of-human-nose-shape-and-climate-adaptation
#5
Arslan A Zaidi, Brooke C Mattern, Peter Claes, Brian McEcoy, Cris Hughes, Mark D Shriver
The evolutionary reasons for variation in nose shape across human populations have been subject to continuing debate. An import function of the nose and nasal cavity is to condition inspired air before it reaches the lower respiratory tract. For this reason, it is thought the observed differences in nose shape among populations are not simply the result of genetic drift, but may be adaptations to climate. To address the question of whether local adaptation to climate is responsible for nose shape divergence across populations, we use Qst-Fst comparisons to show that nares width and alar base width are more differentiated across populations than expected under genetic drift alone...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28296936/spatial-analysis-improves-the-detection-of-early-corneal-nerve-fiber-loss-in-patients-with-recently-diagnosed-type-2-diabetes
#6
Dan Ziegler, Karsten Winter, Alexander Strom, Andrey Zhivov, Stephan Allgeier, Nikolaos Papanas, Iris Ziegler, Jutta Brüggemann, Bernd Ringel, Sabine Peschel, Bernd Köhler, Oliver Stachs, Rudolf F Guthoff, Michael Roden
Corneal confocal microscopy (CCM) has revealed reduced corneal nerve fiber (CNF) length and density (CNFL, CNFD) in patients with diabetes, but the spatial pattern of CNF loss has not been studied. We aimed to determine whether spatial analysis of the distribution of corneal nerve branching points (CNBPs) may contribute to improving the detection of early CNF loss. We hypothesized that early CNF decline follows a clustered rather than random distribution pattern of CNBPs. CCM, nerve conduction studies (NCS), and quantitative sensory testing (QST) were performed in a cross-sectional study including 86 patients recently diagnosed with type 2 diabetes and 47 control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28287532/dynamic-quantitative-sensory-testing-to-characterize-central-pain-processing
#7
Ian G Mackey, Eric A Dixon, Kevin Johnson, Jiang-Ti Kong
Central facilitation and modulation of incoming nociceptive signals play an important role in the perception of pain. Disruption in central pain processing is present in many chronic pain conditions and can influence responses to specific therapies. Thus, the ability to precisely describe the state of central pain processing has profound clinical significance in both prognosis and prediction. Because it is not practical to record neuronal firings directly in the human spinal cord, surrogate behavior tests become an important tool to assess the state of central pain processing...
February 16, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28271298/post-operative-orofacial-pain-temporomandibular-dysfunction-and-trigeminal-sensitivity-after-recent-pterional-craniotomy-preliminary-study
#8
Thiago Medina Brazoloto, Silvia Regina Dowgan Tesseroli de Siqueira, Pedro Augusto Sampaio Rocha-Filho, Eberval Gadelha Figueiredo, Manoel Jacobsen Teixeira, José Tadeu Tesseroli de Siqueira
BACKGROUND: Surgical trauma at the temporalis muscle is a potential cause of post-craniotomy headache and temporomandibular disorders (TMD). The aim of this study was to evaluate the prevalence of pain, masticatory dysfunction and trigeminal somatosensory abnormalities in patients who acquired aneurysms following pterional craniotomy. METHODS: Fifteen patients were evaluated before and after the surgical procedure by a trained dentist. The evaluation consisted of the (1) research diagnostic criteria for TMD, (2) a standardized orofacial pain questionnaire and (3) a systematic protocol for quantitative sensory testing (QST) for the trigeminal nerve...
March 7, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28221302/diagnostic-criteria-for-small-fiber-neuropathy
#9
Derrick Blackmore, Zaeem A Siddiqi
OBJECTIVES: Despite its relative common occurrence, definitive diagnosis of small fiber neuropathy (SFN) remains problematic. In practice, patients with pain, numbness, and/or paresthesias in their lower limbs are diagnosed with SFN if found to have dissociated sensory loss in their feet, that is, impaired pinprick perception (PP) but relatively preserved vibration. We sought to assess the sensitivity and specificity of clinical examination and various diagnostic tools available for screening SFN...
March 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28195718/improvement-of-methane-framework-interaction-by-controlling-pore-size-and-functionality-of-pillared-mofs
#10
Sayed Ali Akbar Razavi, Mohammad Yaser Masoomi, Timur Islamoglu, Ali Morsali, Yan Xu, Joseph T Hupp, Omar K Farha, Jun Wang, Peter C Junk
The rational design of functionalized porous metal-organic frameworks (MOFs) for gas adsorption applications has been applied using three spacer ligands H2DPT (3,6-di(pyridin-4-yl)-1,4-dihydro-1,2,4,5-tetrazine), DPT (3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine), and BPDH (2,5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene) to synthesize TMU-34, [Zn(OBA)(H2DPT)0.5]n·DMF, TMU-34(-2H), [Zn(OBA)(DPT)0.5]n·DMF, and TMU-5, [Zn(OBA)(BPDH)0.5]n·1.5DMF, respectively. By controlling the pore size and chemical functionality of these three MOFs, we can improve the interactions between CO2 and especially CH4 with the frameworks...
February 14, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28160223/quantitative-sensory-testing-in-adults-with-autism-spectrum-disorders
#11
Odette Fründt, Wiebke Grashorn, Daniel Schöttle, Ina Peiker, Nicole David, Andreas K Engel, Katarina Forkmann, Nathalie Wrobel, Alexander Münchau, Ulrike Bingel
Altered sensory perception has been found in patients with autism spectrum disorders (ASD) and might be related to aberrant sensory perception thresholds. We used the well-established, standardized Quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain to investigate 13 somatosensory parameters including thermal and tactile detection and pain thresholds in 13 ASD adults and 13 matched healthy controls with normal IQ values. There were no group differences between somatosensory detection and pain thresholds...
February 3, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28157282/chalcogenide-aerogels-as-sorbents-for-noble-gases-xe-kr
#12
Kota S Subrahmanyam, Ioannis Spanopoulos, Jaehun Chun, Brian J Riley, Praveen K Thallapally, Pantelis N Trikalitis, Mercouri G Kanatzidis
High-surface-area molybdenum sulfide (MoSx) and antimony sulfide (SbSx) chalcogels were studied for Xe/Kr gas separation. The intrinsic soft Lewis basic character of the chalcogel framework is a unique property among the large family of porous materials and lends itself to a potential new approach toward the selective separation of Xe over Kr. Among these chalcogels, MoSx shows the highest Xe and Kr uptake, reaching 0.69 mmol g(-1) (1.05 mmol cm(-3)) and 0.28 mmol g(-1) (0.42 mmol cm(-3)) respectively, at 273 K and 1 bar...
February 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28146319/unimpaired-endogenous-pain-inhibition-in-the-early-phase-of-complex-regional-pain-syndrome
#13
N Kumowski, T Hegelmaier, J Kolbenschlag, C Maier, T Mainka, J Vollert, E Enax-Krumova
BACKGROUND: The complex regional pain syndrome (CRPS) is characterized by distal generalisation of pain beyond the initial trauma. This might be the result of impaired endogenous pain inhibition. METHOD: We compared Conditioned Pain Modulation (CPM) between patients with CRPS (n = 24; pain: 4.5 ± 2.2, NRS 0-10; disease duration <1 year), neuralgia (n = 17; pain: 5.5 ± 1.1) and healthy subjects (n = 23) and its correlation with loss and gain of function as assessed by Quantitative Sensory Testing (QST)...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28131214/quantitative-sensory-testing-and-structural-assessment-of-sensory-nerve-fibres-in-amyotrophic-lateral-sclerosis
#14
Baris Isak, Kirsten Pugdahl, Páll Karlsson, Hatice Tankisi, Nanna Brix Finnerup, Jasna Furtula, Birger Johnsen, Niels Sunde, Johannes Jakobsen, Anders Fuglsang-Frederiksen
OBJECTIVE: In this prospective study, involvement of sensory nerve fibres in ALS patients was assessed using functional and structural measures in the form of quantitative sensory testing (QST) and skin and nerve biopsies. METHODS: Thirty-two ALS patients and 32 healthy subjects were evaluated with a QST battery comprising thresholds of mechanical detection, mechanical pain, vibration detection, cold detection, warm detection, heat pain, and pinprick sensation. Skin biopsies were evaluated in 31 ALS patients by intraepidermal nerve fibre density (IENFD) and axonal swelling ratios, and growth-associated protein 43 (GAP-43) antibody staining...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28118423/effect-of-experimental-periodontal-ligament-pain-on-gingival-somatosensory-sensitivity
#15
Shengyi Lu, Peter Svensson, Zhenting Zhang, Thomas List, Lene Baad-Hansen
AIMS: To use a randomized, blinded, crossover design to evaluate the possible heterotopic effects of experimental periodontal ligament pain on adjacent gingival somatosensory sensitivity. METHODS: A total of 12 healthy volunteers (8 female, 4 male; mean age ± standard error in means (SEM): 28 ± 1 years) participated in two randomized experimental quantitative sensory testing (QST) sessions, one in which capsaicin (experimental) was injected into the periodontal ligament and one in which isotonic saline (control) was injected...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28118417/pain-from-dental-implant-placement-inflammatory-pulpitis-pain-and-neuropathic-pain-present-different-somatosensory-profiles
#16
André Luís Porporatti, Leonardo Rigoldi Bonjardim, Juliana Stuginski-Barbosa, Estevam Augusto Bonfante, Yuri Martins Costa, Paulo César Rodrigues Conti
AIMS: To address the two following questions: (1) What kind of somatosensory abnormalities may be characterized in patients receiving dental implants (IMP), in ongoing inflammatory dental pulpitis (IP) patients, and in neuropathic pain (atypical odontalgia [AO]) patients? and (2) What sort of sensory and neural changes may result from dental implant placement surgery and pulpectomy? METHODS: A total of 60 subjects were divided into three groups: the IMP (n = 20), IP (n = 20), and AO groups (n = 20)...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28117333/usefulness-of-laser-evoked-potentials-and-quantitative-sensory-testing-in-the-diagnosis-of-neuropathic-spinal-cord-injury-pain-a-multiple-case-study
#17
G Landmann, M F Berger, L Stockinger, E Opsommer
STUDY DESIGN: A retrospective study. OBJECTIVES: The aim of this study was to investigate the contribution of laser-evoked potentials (LEPs) and quantitative sensory testing (QST) to the diagnosis of neuropathic pain in patients with spinal cord injury (SCI) and inconclusive magnetic resonance imaging (MRI) findings. SETTING: A multidisciplinary pain center. METHODS: QST (DFNS protocol) and Tm-YAG-laser stimulation of the skin were applied within the pain site corresponding with dermatomes of altered sensation...
January 24, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28106324/verbal-instructions-influence-pain-thresholds-assessment-a-study-using-manual-and-electronic-mechanical-stimulators
#18
K Suzuki, L Baad-Hansen, P Svensson
BACKGROUND: Quantitative sensory testing (QST) relies on psychophysical techniques and instructions to test subjects. This study examined the effect of different verbal instructions for mechanical pain thresholds (MPTs) using two different stimulation techniques; weighted pinprick stimulators and an electronic von Frey device (EvF). The test-retest reliability and within session variability in the MPTs for each verbal instruction were compared in addition. METHODS: Sixteen healthy volunteers participated...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28091815/quantitative-validation-of-sensory-mapping-in-persistent-postherniorrhaphy-inguinal-pain-patients-undergoing-triple-neurectomy
#19
M F Bjurström, R Álvarez, A L Nicol, R Olmstead, P K Amid, D C Chen
PURPOSE: Neurectomy of the inguinal nerves may be considered for selected refractory cases of chronic postherniorrhaphy inguinal pain (CPIP). There is to date a paucity of easily applicable clinical tools to identify neuropathic pain and examine the neurosensory effects of remedial surgery. The present quantitative sensory testing (QST) pilot study evaluates a sensory mapping technique. METHODS: Longitudinal (preoperative, immediate postoperative, and late postoperative) dermatomal sensory mapping and a comprehensive QST protocol were conducted in CPIP patients with unilateral, predominantly neuropathic inguinodynia presenting for triple neurectomy (n = 13)...
April 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28067993/on-the-structure-property-relationships-of-cation-exchanged-zk-5-zeolites-for-co2-adsorption
#20
Trong D Pham, Matthew R Hudson, Craig M Brown, Raul F Lobo
The CO2 adsorption properties of cation-exchanged Li-, Na-, K-, and Mg-ZK-5 zeolites were correlated to the molecular structures determined by Rietveld refinements of synchrotron powder X-ray diffraction patterns. Li-, K-, and Na-ZK-5 all exhibited high isosteric heats of adsorption (Qst ) at low CO2 coverage, with Na-ZK-5 having the highest Qst (ca. 49 kJ mol(-1) ). Mg(2+) was located at the center of the zeolite hexagonal prism with the cation inaccessible to CO2 , leading to a much lower Qst (ca. 30 kJ mol(-1) ) and lower overall uptake capacity...
January 9, 2017: ChemSusChem
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