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https://www.readbyqxmd.com/read/27891714/altered-serum-level-of-matrix-metalloproteinase-9-and-its-association-with-decision-making-in-eating-disorders
#1
Junko Matsumoto, Yoshiyuki Hirano, Kenji Hashimoto, Tamaki Ishima, Nobuhisa Kanahara, Tomihisa Niitsu, Akihiro Shiina, Tasuku Hashimoto, Yasunori Sato, Koutaro Yokote, Shunichi Murano, Hiroshi Kimura, Yutaka Hosoda, Eiji Shimizu, Masaomi Iyo, Michiko Nakazato
AIMS: The aims of this study were to determine whether the serum levels of precursor brain-derived neurotrophic factor (proBDNF), mature BDNF (mBDNF), and matrix metalloproteinase-9 (MMP-9) are altered in patients with eating disorders (EDs) including anorexia nervosa (AN) and bulimia nervosa (BN), and to explore whether those levels are associated with decision-making abilities. METHODS: Nineteen women with AN, 28 women with BN, and 22 age-matched healthy women (HC) were enrolled in the current study...
November 28, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27882331/ectopic-fat-deposition-on-insulin-sensitivity-correlation-of-hepatocellular-lipid-content-and-m-value
#2
Beverly S Hong, Ying Li, Shuiqing Lai, Juan Liu, Hongyu Guan, Weijian Ke, Xiaoying He, Yanbing Li
Purpose. This study aimed to explore the relationship among insulin sensitivity and ectopic fat depots in participants with different glucose status. Methods. Fifty-nine men and women were enrolled in this study: 29 with normal glucose tolerance (NGT), 17 with impaired glucose tolerance (IGT), and 13 with type 2 diabetes mellitus (T2DM). All participants underwent a hyperinsulinemic-euglycemic clamp to assess the insulin sensitivity index (M value) and magnetic resonance imaging to measure the hepatocellular lipid content (HCL), skeletal muscle fat content including intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) of tibialis anterior (ta), and soleus muscle (sol)...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27882006/framingham-risk-score-in-impaired-glucose-tolerant-population-a-sub-analysis-of-diabetes-prevention-and-awareness-program-of-pakistan
#3
Asher Fawwad, Hassan Moin, Iftikhar Ahmed Siddiqui, Muhammad Zafar Iqbal Hydrie, Abdul Basit
OBJECTIVE: To assess the 10-year risk of coronary artery disease (CAD) in subjects with impaired glucose tolerance (IGT) using Framingham risk score. METHODS: Data for this study was collected from Diabetes Prevention and Awareness Program. Primary prevention team visited different primary health care centers, factories, service organizations and offices within Karachi, Pakistan. IGT was diagnosed according to World Health Organization criteria after taking informed consent...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27870900/to-fear-is-to-gain-the-role-of-fear-recognition-in-risky-decision-making-in-tbi-patients-and-healthy-controls
#4
Annemarie C Visser-Keizer, Herma J Westerhof-Evers, Marleen J J Gerritsen, Joukje van der Naalt, Jacoba M Spikman
Fear is an important emotional reaction that guides decision making in situations of ambiguity or uncertainty. Both recognition of facial expressions of fear and decision making ability can be impaired after traumatic brain injury (TBI), in particular when the frontal lobe is damaged. So far, it has not been investigated how recognition of fear influences risk behavior in healthy subjects and TBI patients. The ability to recognize fear is thought to be related to the ability to experience fear and to use it as a warning signal to guide decision making...
2016: PloS One
https://www.readbyqxmd.com/read/27869717/inflammatory-properties-of-diet-and-glucose-insulin-homeostasis-in-a-cohort-of-iranian-adults
#5
Nazanin Moslehi, Behnaz Ehsani, Parvin Mirmiran, Nitin Shivappa, Maryam Tohidi, James R Hébert, Fereidoun Azizi
We aimed to investigate associations of the dietary inflammatory index (DII) with glucose-insulin homeostasis markers, and the risk of glucose intolerance. This cross-sectional study included 2975 adults from the Tehran Lipid and Glucose Study. Fasting plasma glucose (FPG), 2-h post-load glucose (2h-PG), and fasting serum insulin were measured. Homeostatic model assessment of insulin resistance index (HOMA-IR) and β-cell function (HOMA-B), and the quantitative insulin sensitivity check index (QUICKI) were calculated...
November 18, 2016: Nutrients
https://www.readbyqxmd.com/read/27857694/comparable-attenuation-of-sympathetic-nervous-system-activity-in-obese-subjects-with-normal-glucose-tolerance-impaired-glucose-tolerance-and-treatment-na%C3%A3-ve-type-2-diabetes-following-equivalent-weight-loss
#6
Nora E Straznicky, Mariee T Grima, Carolina I Sari, Elisabeth A Lambert, Sarah E Phillips, Nina Eikelis, Justin A Mariani, Daisuke Kobayashi, Dagmara Hering, John B Dixon, Gavin W Lambert
Background and Purpose: Elevated sympathetic nervous system (SNS) activity is a characteristic of obesity and type 2 diabetes (T2D) that contributes to target organ damage and cardiovascular risk. In this study we examined whether baseline metabolic status influences the degree of sympathoinhibition attained following equivalent dietary weight loss. Methods: Un-medicated obese individuals categorized as normal glucose tolerant (NGT, n = 15), impaired glucose tolerant (IGT, n = 24), and newly-diagnosed T2D (n = 15) consumed a hypocaloric diet (29% fat, 23% protein, 45% carbohydrate) for 4-months...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27854028/impaired-fasting-glucose-and-impaired-glucose-tolerance-in-children-and-adolescents-with-overweight-obesity
#7
P Di Bonito, L Pacifico, C Chiesa, G Valerio, E Miraglia Del Giudice, C Maffeis, A Morandi, C Invitti, M R Licenziati, S Loche, G Tornese, F Franco, M Manco, M G Baroni
OBJECTIVE: To investigate in a large sample of overweight/obese (OW/OB) children and adolescents the prevalence of prediabetic phenotypes such as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and to assess their association with cardiometabolic risk (CMR) factors including hepatic steatosis (HS). METHODS: Population data were obtained from the CARdiometabolic risk factors in children and adolescents in ITALY study. Between 2003 and 2013, 3088 youths (972 children and 2116 adolescents) received oral glucose tolerance test (OGTT) and were included in the study...
November 16, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27836240/influence-of-comt-val-158-met-polymorphism-on-emotional-decision-making-a-sex-dependent-relationship
#8
Danielle de Souza Costa, Antoine Bechara, Jonas Jardim de Paula, Marco Aurélio Romano-Silva, Humberto Correa, Guilherme Menezes Lage, Débora Marques de Miranda, Leandro Fernandes Malloy-Diniz
The biological underpinnings of sex-related differences in decision-making are still under-explored. The COMT gene is related to sexual dimorphism and with different choices made under uncertainty, albeit no study has specifically investigated a moderation effect of sex on the association between the COMT gene and the performance on decision-making paradigms. In this study, we investigated the influence of the COMT Val(158)Met polymorphism on Iowa Gambling Task (IGT) performance depending on sex in a healthy adult sample...
November 1, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27829582/postprandial-hyperlipidemia-and-remnant-lipoproteins
#9
Daisaku Masuda, Shizuya Yamashita
Fasting hypertriglyceridemia is positively associated with the morbidity of coronary heart disease (CHD), and postprandial (non-fasting) hypertriglyceridemia is also correlated with the risk status for CHD, which is related to the increase in chylomicron (CM) remnant lipoproteins produced from the intestine. CM remnant particles, as well as oxidized low density lipoprotein (LDL) or very low density lipoprotein (VLDL) remnants, are highly atherogenic and act by enhancing systemic inflammation, platelet activation, coagulation, thrombus formation, and macrophage foam cell formation...
November 8, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27816782/contribution-of-different-regions-of-the-prefrontal-cortex-and-lesion-laterality-to-deficit-of-decision-making-on-the-iowa-gambling-task
#10
Riadh Ouerchefani, Naoufel Ouerchefani, Philippe Allain, Mohamed Riadh Ben Rejeb, Didier Le Gall
Few studies have examined the contribution of different sub-regions of the prefrontal cortex and lesion laterality to decision-making abilities. In addition, there are inconsistent findings about the role of ventromedial and dorsolateral lesions in decision-making deficit. In this study, decision-making processes are investigated following different damaged areas of the prefrontal cortex. We paid particular attention to the contribution of laterality, lesion location and lesion volume in decision-making deficit...
November 2, 2016: Brain and Cognition
https://www.readbyqxmd.com/read/27798659/double-trouble-prevalence-and-factors-associated-with-tuberculosis-and-diabetes-comorbidity-in-bangladesh
#11
Malabika Sarker, Mrittika Barua, Fiona Guerra, Avijit Saha, Afzal Aftab, A H M Mahbub Latif, Shayla Islam, Akramul Islam
BACKGROUND: Diabetes among tuberculosis patients increases the risk of tuberculosis treatment failure, death, and development of multidrug-resistant tuberculosis. Yet, there is no data is available in Bangladesh on the prevalence of diabetes among tuberculosis patients. The objective of the current study was to estimate prevalence and identify factors associated with tuberculosis-diabetes co-morbidity among TB patients enrolled in the Directly Observed Treatment, Short course program...
2016: PloS One
https://www.readbyqxmd.com/read/27798255/decision-making-impairments-following-insular-and-medial-temporal-lobe-resection-for-drug-resistant-epilepsy
#12
Zorina Von Siebenthal, Olivier Boucher, Isabelle Rouleau, Maryse Lassonde, Franco Lepore, Dang K Nguyen
Besides the prefrontal cortex, the insula and medial structures of the temporal lobe are thought to be involved in risky decision-making. However, their respective contributions to decision processes remain unclear due to the lack of studies involving patients with isolated insular damage. We assessed adult patients who underwent resection of the insula (n = 13) or of the anterior temporal lobe (including medial structures) (n = 13) as part of their epilepsy surgery, and a group of healthy volunteers (n = 20), on the Iowa Gambling Task (IGT) and on the Cups Task...
October 19, 2016: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/27795816/update-on-pre-diabetes-focus-on-diagnostic-criteria-and-cardiovascular-risk
#13
REVIEW
Antonino Di Pino, Francesca Urbano, Salvatore Piro, Francesco Purrello, Agata Maria Rabuazzo
Pre-diabetes, which is typically defined as blood glucose concentrations higher than normal but lower than the diabetes threshold, is a high-risk state for diabetes and cardiovascular disease development. As such, it represents three groups of individuals: Those with impaired fasting glucose (IFG), those with impaired glucose tolerance (IGT) and those with a glycated haemoglobin (HbA1c) between 39-46 mmol/mol. Several clinical trials have shown the important role of IFG, IGT and HbA1c-pre-diabetes as predictive tools for the risk of developing type 2 diabetes...
October 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27746259/higher-insulin-and-higher-body-fat-via-leptin-are-associated-with-disadvantageous-decisions-in-the-iowa-gambling-task
#14
Douglas C Chang, Paolo Piaggi, Joushua E Burkholder, Susanne B Votruba, Jonathan Krakoff, Marci E Gluck
Elevated body mass index and post-prandial state are associated with disadvantageous choices on the Iowa Gambling Task (IGT). Whether physiological factors including percent body fat, and peripheral glucose, insulin, and leptin concentrations, are associated with IGT performance is unknown. In196 healthy adults without diabetes, we measured body fat by DXA scan, glucose, insulin and leptin (n=138) concentrations during an oral glucose tolerance test and IGT performance after a standardized meal. Glucose was not associated with IGT performance...
October 13, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27740930/progression-from-impaired-glucose-tolerance-to-type-2-diabetes-in-obese-children-and-adolescents-a-3-6-year-cohort-study-in-southern-thailand
#15
Somchit Jaruratanasirikul, Sudarat Thammaratchuchai, Maneerat Puwanant, Ladda Mo-Suwan, Hutcha Sriplung
BACKGROUND: Childhood obesity is associated with abnormal glucose metabolism and type 2 diabetes mellitus (T2DM). This study evaluated the prevalence of abnormal glucose metabolism in asymptomatic obese children and adolescents, and determined the percentage of T2DM development after 3-6 years of follow-up. METHODS: During 2007-2013, 177 obese children and adolescents who had normal fasting plasma glucose (FPG<100 mg/dL) were given an oral glucose tolerance test (OGTT)...
November 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27737744/arterial-effects-of-canakinumab-in-patients%C3%A2-with-atherosclerosis-and-type%C3%A2-2%C3%A2-diabetes-or-glucose-intolerance
#16
Robin P Choudhury, Jacqueline S Birks, Venkatesh Mani, Luca Biasiolli, Matthew D Robson, Philippe L L'Allier, Marc-Alexandre Gingras, Nadia Alie, Mary Ann McLaughlin, Craig T Basson, Alison D Schecter, Eric C Svensson, Yiming Zhang, Denise Yates, Jean-Claude Tardif, Zahi A Fayad
BACKGROUND: Evidence suggests that interleukin (IL)-1β is important in the pathogenesis of atherosclerosis and its complications and that inhibiting IL-1β may favorably affect vascular disease progression. OBJECTIVES: The goal of this study was to evaluate the effects of IL-1β inhibition with canakinumab versus placebo on arterial structure and function, determined by magnetic resonance imaging. METHODS: Patients (N = 189) with atherosclerotic disease and either type 2 diabetes mellitus or impaired glucose tolerance were randomized to receive placebo (n = 94) or canakinumab 150 mg monthly (n = 95) for 12 months...
October 18, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27736893/detection-of-independent-associations-of-plasma-lipidomic-parameters-with-insulin-sensitivity-indices-using-data-mining-methodology
#17
Steffi Kopprasch, Srirangan Dheban, Kai Schuhmann, Aimin Xu, Klaus-Martin Schulte, Charmaine J Simeonovic, Peter E H Schwarz, Stefan R Bornstein, Andrej Shevchenko, Juergen Graessler
OBJECTIVE: Glucolipotoxicity is a major pathophysiological mechanism in the development of insulin resistance and type 2 diabetes mellitus (T2D). We aimed to detect subtle changes in the circulating lipid profile by shotgun lipidomics analyses and to associate them with four different insulin sensitivity indices. METHODS: The cross-sectional study comprised 90 men with a broad range of insulin sensitivity including normal glucose tolerance (NGT, n = 33), impaired glucose tolerance (IGT, n = 32) and newly detected T2D (n = 25)...
2016: PloS One
https://www.readbyqxmd.com/read/27733250/a-human-model-of-dietary-saturated-fatty-acid-induced-insulin-resistance
#18
Juraj Koska, Marlies K Ozias, James Deer, Julie Kurtz, Arline D Salbe, S Mitchell Harman, Peter D Reaven
BACKGROUND: Increased consumption of high-fat diets is associated with the development of insulin resistance and type 2 diabetes. Current models to study the mechanisms of high-fat diet-induced IR in humans are limited by their long duration or low efficacy. In the present study we developed and characterized an acute dietary model of saturated fatty acid-enriched diet induced insulin resistance. METHODS: High caloric diets enriched with saturated fatty acids (SFA) or carbohydrates (CARB) were evaluated in subjects with normal and impaired glucose tolerance (NGT or IGT)...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27730082/relationship-of-glycemic-control-markers-1-5-anhydroglucitol-fructosamine-and-glycated-hemoglobin-among-asian-indians-with-different-degrees-of-glucose-intolerance
#19
Thyparambil Aravindakshan Pramodkumar, Ramamoorthy Jayashri, Kuppan Gokulakrishnan, Kaliyaperumal Velmurugan, Rajendra Pradeepa, Ranjit Mohan Anjana, Viswanathan Mohan
OBJECTIVE: 1,5 anhydroglucitol (1,5 AG) is emerging as a marker of short-term glycemic control. We measured levels of 1,5 AG, fructosamine (FA), and glycated hemoglobin (HbA1c) in Asian Indians with different degrees of glucose intolerance. MATERIALS AND METHODS: We recruited 210 individuals with normal glucose tolerance (NGT; n = 60), impaired glucose tolerance (IGT; n = 50), and Type 2 diabetes mellitus (T2DM; n = 100) from a large tertiary diabetes center in Chennai in Southern India...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27703440/anodal-stimulation-of-the-left-dlpfc-increases-igt-scores-and-decreases-delay-discounting-rate-in-healthy-males
#20
Qinghua He, Mei Chen, Chuansheng Chen, Gui Xue, Tingyong Feng, Antoine Bechara
Previous correlational imaging studies have implicated the dorsolateral prefrontal cortex (DLPFC) in decision making. Using High-Definition Transcranial Direct Current Stimulation (HD-tDCS), the present study directly investigated the causal role of the DLPFC in performing the Iowa Gambling Task (IGT) and the Inter-Temporal Choice (ITC) task. Three experiments were conducted: Experiment 1 (N = 41) to study the left DLPFC, Experiment 2 (N = 49) to study the right DLPFC, and Experiment 3 (N = 20, a subset of those in Experiment 1) to switch the experimental and control conditions...
2016: Frontiers in Psychology
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