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https://www.readbyqxmd.com/read/28093841/effect-of-valsartan-on-kidney-outcomes-in-people-with-impaired-glucose-tolerance
#1
Gemma Currie, M Angelyn Bethel, Björn Holzhauer, Steven M Haffner, Rury R Holman, John J V McMurray
AIMS: Renin-angiotensin system blockers reduce the incidence and progression of microalbuminuria and the subsequent development of end-stage renal disease (ESRD) in patients with type 2 diabetes. We aimed to examine the effect of valsartan on kidney outcomes in patients with impaired glucose tolerance (IGT). METHODS: In a double-blind randomized trial, 9306 patients with IGT were assigned to valsartan (160 mg daily) or placebo. The co-primary endpoints were the development of diabetes and two composite cardiovascular outcomes...
January 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28093302/aging-and-risky-decision-making-new-erp-evidence-from-the-iowa-gambling-task
#2
Elisa Di Rosa, Daniela Mapelli, Giorgio Arcara, Piero Amodio, Stefano Tamburin, Sami Schiff
Several pieces of evidence have highlighted the presence of an age-related decline in risky decision-making (DM), but the reason of this decline is still unclear. The aim of the present study was to investigate the neural correlates of feedback processing in risky DM. Twenty-one younger (age <50 years) and 15 older (age >50 years) adults were tested with the Iowa Gambling Task (IGT) during Event Related Potentials (ERP) recording. The analysis was focused on the feedback-related negativity (FRN) and P3, two ERP components that represent different stages of feedback processing...
January 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28092195/serum-bdnf-levels-in-patients-with-gambling-disorder-are-associated-with-the-severity-of-gambling-disorder-and-iowa-gambling-task-indices
#3
Sam-Wook Choi, Young-Chul Shin, Jung Yeon Mok, Dai-Jin Kim, Jung-Seok Choi, Samuel Suk-Hyun Hwang
Background and aims Gambling disorder (GD) shares many similarities with substance use disorders (SUDs) in clinical, neurobiological, and neurocognitive features, including decision-making. We evaluated the relationships among, GD, decision-making, and brain-derived neurotrophic factor (BDNF), as measured by serum BDNF levels. Methods Twenty-one male patients with GD and 21 healthy sex- and age-matched control subjects were evaluated for associations between serum BDNF levels and the Problem Gambling Severity Index (PGSI), as well as between serum BDNF levels and Iowa Gambling Task (IGT) indices...
March 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28076317/high-predictability-of-impaired-glucose-tolerance-by-combining-cardiometabolic-screening-parameters-in-obese-children
#4
Cornelis Jan de Groot, Jeroen van der Grond, Yosine Delgado, Edmond H H M Rings, Sabine E Hannema, Erica L T van den Akker
BACKGROUND: There is debate on which overweight and obese children should be screened for the presence of impaired glucose tolerance (IGT) by oral glucose tolerance testing (OGTT). The objective of the study was to identify risk factors predictive of the presence of IGT. METHODS: In a cohort of overweight children, who underwent OGTT, we determined the association of anthropometric and laboratory parameters with IGT and whether combining parameters improved the sensitivity of screening for IGT...
January 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28068900/galectin-3-and-fibulin-1-in-systolic-heart-failure-relation-to-glucose-metabolism-and-left-ventricular-contractile-reserve
#5
Pernille Holmager, Michael Egstrup, Ida Gustafsson, Morten Schou, Jordi S Dahl, Lars Melholt Rasmussen, Jacob E Møller, Christian Tuxen, Jens Faber, Caroline Kistorp
BACKGROUND: Heart failure (HF) patients with diabetes (DM) have an adverse prognosis and reduced functional capacity, which could be associated with cardiac fibrosis, increased chamber stiffness and reduced left ventricular (LV) contractile reserve. Galectin-3 (Gal-3) and fibulin-1 are circulating biomarkers potentially reflecting cardiac fibrosis. We hypothesize that plasma levels of Gal-3 and fibulin-1 are elevated in HF patients with DM and are associated with reduced LV contractile reserve in these patients...
January 10, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28067023/elevated-serum-milk-fat-globule-epidermal-growth-factor-8-levels-in-type-2-diabetic-patients-are-suppressed-by-overweight-or-obese-status
#6
Yuanyuan Li, Wenzhuo Ran, Jiaqiang Zhang, Shi Chen, Yihang Li, Deng Luo, Chen Wang, Weiping Jia
Inflammation is the most important link between obesity and type 2 diabetes (T2D). Although milk fat globule-epidermal growth factor 8 (MFG-E8) is a key mediator in anti-inflammatory responses, its role in obesity and diabetes is not yet completely understood. We aimed to measure MFG-E8 serum levels and to explore the role of MFG-E8 in obesity and T2D. Fasting serum MFG-E8 levels were quantified by enzyme-linked immunosorbent assay for 168 individuals, whose oral glucose tolerance test was conducted, and levels of inflammatory factors, including tumor necrosis factor-α (TNF-α) and C-reactive protein, were measured...
January 9, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28065206/iowa-gambling-task-performance-prospectively-predicts-changes-in-glycemic-control-among-adolescents-with-type-1-diabetes
#7
Yana Suchy, Tara L Queen, Bryce Huntbach, Deborah J Wiebe, Sara L Turner, Jonathan Butner, Caitlin S Kelly, Perrin C White, Mary Murray, Michael Swinyard, Cynthia A Berg
OBJECTIVES: Good glycemic control is an important goal of diabetes management. Late adolescents with type 1 diabetes (T1D) are at risk for poor glycemic control as they move into young adulthood. For a subset of these patients, this dysregulation is extreme, placing them at risk for life-threatening health complications and permanent cognitive declines. The present study examined whether deficiency in emotional decision making (as measured by the Iowa Gambling Task; IGT) among teens with T1D may represent a neurocognitive risk factor for subsequent glycemic dysregulation...
January 9, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28062226/molecular-characterization-and-expression-analysis-of-three-subclasses-of-igt-in-rainbow-trout-oncorhynchus-mykiss
#8
Nu Zhang, Xu-Jie Zhang, Dan-Dan Chen, J Oriol Sunyer, Yong-An Zhang
As the teleost specific immunoglobulin, IgT plays important roles in systemic and mucosal immunity. In the current study, in rainbow trout, we have cloned the heavy chain (Igτ) genes of a secretory form of IgT2 as well as the membrane and secretory forms of a third IgT subclass, termed IgT3. Conserved cysteine and tryptophan residues that are crucial for the folding of the immunoglobulin domain as well as hydrophobic and hydrophilic residues within CART motif were identified in all IgT subclasses. Through analysis of the rainbow trout genome assembly, Igτ3 gene was found localized upstream of Igτ1 gene, while Igτ2 gene situated on another scaffold...
January 3, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28052966/role-of-adipose-tissue-insulin-resistance-in-the-natural-history-of-t2dm-results-from-the-san-antonio-metabolism-study
#9
Amalia Gastaldelli, Melania Gaggini, Ralph A DeFronzo
In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However, the impact of dysfunctional adipose tissue has not been fully elucidated. The aim of the present study is to evaluate the role of resistance to the antilipolytic effect of insulin (Adipo-IR) in a large group of NGT, IGT and T2DM subjects.302 subjects with varying glucose tolerance received OGTT and euglycemic insulin clamp...
January 4, 2017: Diabetes
https://www.readbyqxmd.com/read/28043048/incidence-and-predictors-of-type-2-diabetes-among-koreans-a-12-year-follow-up-of-the-korean-genome-and-epidemiology-study
#10
Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan Woo Lee, Nam H Cho
AIM: Because the incidence of type 2 diabetes in Korea has not been clearly defined, we examined the incidence of this condition and its association with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and other risk factors in a 12-year follow-up Korean community-based prospective cohort study. METHODS: We recruited 7542 subjects aged 40-69years without diabetes at baseline examination from the Korean Genome and Epidemiology Study and followed these subjects for 12years biennially...
October 19, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28041666/prediabetes-in-pediatric-recipients-of-liver-transplant-mechanism-and-risk-factors
#11
Emily R Perito, Robert H Lustig, Philip Rosenthal
OBJECTIVE: To investigate the role of calcineurin inhibitor exposure and states of insulin resistance-obesity and adolescence-in prediabetes after pediatric liver transplant via oral glucose tolerance testing, which previously has not been done systematically in these at-risk youths. STUDY DESIGN: This was a cross-sectional study of 81 pediatric recipients of liver transplant. Prediabetes was defined as impaired glucose tolerance (IGT; glucose ≥140 mg/dL at 2 hours) or impaired fasting glucose (IFG, ≥100 mg/dL)...
December 29, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/28029738/dro1-influences-root-system-architecture-in-arabidopsis-and-prunus-species
#12
Jessica M Guseman, Kevin Webb, Chinnathambi Srinivasan, Chris Dardick
Roots provide essential uptake of water and nutrients from the soil, as well as anchorage and stability for the whole plant. Root orientation, or angle, is an important component of the overall architecture and depth of the root system, however little is known about the genetic control of this trait. Recent reports in rice identified a role for DEEPER ROOTING 1(DRO1) in influencing the orientation of the root system, leading to positive changes in grain yields under drought conditions. Here we found that DRO1 and DRO1-related genes are present across diverse plant phyla and fall within the IGT gene family...
December 28, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28029544/lc-ms-ms-method-for-quantitation-of-seven-biomarkers-in-human-plasma-for-the-assessment-of-insulin-resistance-and-impaired-glucose-tolerance
#13
Qibo Zhang, Lisa A Ford, Kelli D Goodman, Tiffany A Freed, Deirdre M Hauser, Jessie K Conner, Kate E T Vroom, Douglas R Toal
Early detection of insulin resistance (IR) and/or impaired glucose tolerance (IGT) is crucial for delaying and preventing the progression toward type 2 diabetes. We recently developed and validated a straightforward metabolite-based test for the assessment of IR and IGT in a single LC-MS/MS method. Plasma samples were diluted with isotopically-labeled internal standards and extracted by simple protein precipitation. The extracts were analyzed by LC-MS/MS for the quantitation of 2-hydroxybutyric acid (0.500-40...
October 24, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28024276/effect-of-lifestyle-interventions-on-glucose-regulation-among-adults-without-impaired-glucose-tolerance-or-diabetes-a-systematic-review-and-meta-analysis
#14
REVIEW
Xuanping Zhang, Giuseppina Imperatore, William Thomas, Yiling J Cheng, Felipe Lobelo, Keri Norris, Heather M Devlin, Mohammed K Ali, Stephanie Gruss, Barbara Bardenheier, Pyone Cho, Isabel Garcia de Quevedo, Uma Mudaliar, Jinan Saaddine, Linda S Geiss, Edward W Gregg
This study systematically assessed the effectiveness of lifestyle interventions on glycemic indicators among adults (⩾18years) without IGT or diabetes. Randomized controlled trials using physical activity (PA), diet (D), or their combined strategies (PA+D) with follow-up ⩾12months were systematically searched from multiple electronic-databases between inception and May 4, 2016. Outcome measures included fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin (FI), homeostasis model assessment-estimated insulin resistance (HOMA-IR), and bodyweight...
December 3, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28017221/decision-making-performance-in-parkinson-s-disease-correlates-with-lateral-orbitofrontal-volume
#15
Mutsutaka Kobayakawa, Natsuko Tsuruya, Mitsuru Kawamura
BACKGROUND: Patients with Parkinson's disease (PD) exhibit poor decision-making, and the underlying neural correlates are unclear. We used voxel-based morphometry with Diffeomorphic Anatomical Registration through Exponentiated Lie algebra to examine this issue. METHODS: The decision-making abilities of 20 patients with PD and 37 healthy controls (HCs) were measured with a computerized Iowa Gambling Task (IGT). We assessed the local gray matter volumes of the patients and HCs and their correlations with decision-making performance, disease duration, disease severity, and anti-Parkinsonism medication dose...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27993703/the-influence-of-concentration-of-inactivated-edwardsiella-tarda-bacterin-and-immersion-time-on-antigen-uptake-and-expression-of-immune-related-genes-in-japanese-flounder-paralichthys-olivaceus
#16
REVIEW
Yang Du, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing, Wenbin Zhan
Our previous work has demonstrated that the immune response of Japanese flounder was associated with the concentration of formalin-inactivated Edwardsiella tarda and immersion time. In order to further investigate the influence of immersion vaccine dose and bath time on the antigen uptake, formalin-killed Edwardsiella tarda bacterin was prepared and adjusted to four concentrations (10(9), 10(8), 10(7), 10(6) cfu ml(-1)) for 30, 60 and 90 min immersion in Japanese flounder model, respectively. Absolute quantitative real-time PCR was employed to examine the bacterin uptake in gill, skin, spleen and kidney at 3 and 6 h post vaccination...
December 16, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27986831/non-suppressed-glucagon-after-glucose-challenge-as-a-potential-predictor-for-glucose-tolerance
#17
Róbert Wagner, Liisa H Hakaste, Emma Ahlqvist, Martin Heni, Jürgen Machann, Fritz Schick, Emmanuel Van Obberghen, Norbert Stefan, Baptist Gallwitz, Tiinamaija Tuomi, Hans-Ulrich Häring, Leif Groop, Andreas Fritsche
Glucagon levels are classically suppressed after glucose challenge. It is still not clear as to whether a lack of suppression contributes to hyperglycemia and thus to the development of diabetes. We investigated the association of post-challenge change in glucagon in three large cohorts of non-diabetic subjects undergoing oral glucose tolerance tests (OGTTs), hypothesizing that higher post-challenge glucagon levels are observed in subjects with impaired glucose tolerance (IGT).Glucagon levels were measured during OGTT in a total of 4194 non-diabetic individuals in three large European cohorts...
December 16, 2016: Diabetes
https://www.readbyqxmd.com/read/27984085/go-for-broke-the-role-of-somatic-states-when-asked-to-lose-in-the-iowa-gambling-task
#18
Rebecca J Wright, Tim Rakow, Riccardo Russo
The Somatic Marker Hypothesis (SMH) posits that somatic states develop and guide advantageous decision making by "marking" disadvantageous options (i.e., arousal increases when poor options are considered). This assumption was tested using the standard Iowa Gambling Task (IGT) in which participants win/lose money by selecting among four decks of cards, and an alternative version, identical in both structure and payoffs, but with the aim changed to lose as much money as possible. This "lose" version of the IGT reverses which decks are advantageous/disadvantageous; and so reverses which decks should be marked by somatic responses - which we assessed via skin conductance (SC)...
October 28, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27978601/cross-sectional-associations-of-impaired-glucose-metabolism-measures-with-bleeding-on-probing-and-periodontitis
#19
Cynthia M Pérez, Francisco Muñoz, Oelisoa M Andriankaja, Christine S Ritchie, Sasha Martínez, José Vergara, José Vivaldi, Lydia López, Maribel Campos, Kaumudi J Joshipura
AIM: This study assessed the associations of pre-diabetes and insulin resistance with bleeding on probing (BOP) and periodontitis among adults. MATERIALS AND METHODS: We included 1191 Hispanic adults aged 40-65 years, free of diabetes, enrolled in San Juan Overweight Adults Longitudinal Study. Pre-diabetes was defined as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or impaired glycated haemoglobin. Impaired one-hour plasma glucose (1hPG) was defined as levels >155 mg/dl...
December 15, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27977404/sensitivity-and-specificity-of-different-methods-for-cystic-fibrosis-related-diabetes-screening-is-the-oral-glucose-tolerance-test-still-the-standard
#20
Catherine Mainguy, Gabriel Bellon, Véronique Delaup, Tiphanie Ginoux, Behrouz Kassai-Koupai, Stéphane Mazur, Muriel Rabilloud, Laurent Remontet, Philippe Reix
BACKGROUND: Cystic fibrosis-related diabetes (CFRD) is a late cystic fibrosis (CF)-associated comorbidity whose prevalence is increasing sharply lifelong. Guidelines for glucose metabolism (GM) monitoring rely on the oral glucose tolerance test (OGTT). However, this test is neither sensitive nor specific. The aim of this study was to compare sensitivity and specificity of different methods for GM monitoring in children and adolescents with CF. METHODS: Continuous glucose monitoring system (CGMS), used as the reference method, was compared with the OGTT, intravenous glucose tolerance test (IGTT), homeostasis model assessment index of insulin resistance (HOMA-IR), homeostasis model assessment index of β-cell function (HOMA-%B) and glycated haemoglobin A1C...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
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