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https://www.readbyqxmd.com/read/29208255/using-ice-cream-for-diagnosis-of-diabetes-mellitus-and-impaired-glucose-tolerance-an-alternative-to-the-oral-glucose-tolerance-test
#1
Wandee Chanprasertpinyo, Nattapimon Bhirommuang, Titiporn Surawattanawiset, Thanwarin Tangsermwong, Pariya Phanachet, Chutintorn Sriphrapradang
BACKGROUND: Oral glucose tolerance test (OGTT) is a sensitive and reliable test for diabetes mellitus and impaired glucose tolerance (IGT). However, poor patient tolerance of glucose solutions is common. We aim to compare the diagnostic value of an ice cream test with a standard OGTT. MATERIALS AND METHODS: A total of 104 healthy adults were randomly assigned to either 75-g OGTT or ice cream, followed by a crossover to the other test. RESULTS: Most patients were females (71%)...
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29205264/diet-physical-activity-or-both-for-prevention-or-delay-of-type-2-diabetes-mellitus-and-its-associated-complications-in-people-at-increased-risk-of-developing-type-2-diabetes-mellitus
#2
REVIEW
Bianca Hemmingsen, Gabriel Gimenez-Perez, Didac Mauricio, Marta Roqué I Figuls, Maria-Inti Metzendorf, Bernd Richter
BACKGROUND: The projected rise in the incidence of type 2 diabetes mellitus (T2DM) could develop into a substantial health problem worldwide. Whether diet, physical activity or both can prevent or delay T2DM and its associated complications in at-risk people is unknown. OBJECTIVES: To assess the effects of diet, physical activity or both on the prevention or delay of T2DM and its associated complications in people at increased risk of developing T2DM. SEARCH METHODS: This is an update of the Cochrane Review published in 2008...
December 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29200427/a-unique-plasma-microrna-profile-defines-type-2-diabetes-progression
#3
Paola de Candia, Gaia Spinetti, Claudia Specchia, Elena Sangalli, Lucia La Sala, Annachiara Uccellatore, Silvia Lupini, Stefano Genovese, Giuseppe Matarese, Antonio Ceriello
A major unmet medical need to better manage Type 2 Diabetes (T2D) is the accurate disease prediction in subjects who show glucose dysmetabolism, but are not yet diagnosed as diabetic. We investigated the possibility to predict/monitor the progression to T2D in these subjects by retrospectively quantifying blood circulating microRNAs in plasma of subjects with i) normal glucose tolerance (NGT, n = 9); ii) impaired glucose tolerance (IGT, n = 9), divided into non-progressors (NP, n = 5) and progressors (P, n = 4) based on subsequent diabetes occurrence, and iii) newly diagnosed T2D (n = 9)...
2017: PloS One
https://www.readbyqxmd.com/read/29198444/endocrine-and-metabolic-assessment-in-adults-with-langerhans-cell-histiocytosis
#4
L Montefusco, S Harari, D Elia, A Rossi, C Specchia, O Torre, G Adda, M Arosio
CONTEXT: Diabetes insipidus (DI) is one of most common complications of Langerhans cell histiocytosis (LCH) but prevalence of anterior pituitary deficiencies and metabolic alterations have not been clearly defined yet. OBJECTIVES: Evaluate prevalence of endocrine and metabolic manifestations in a cohort of patients affected by Pulmonary LCH. METHODS: Observational cross-sectional study on 18 adults (7 M/11 F, 42±12years) studied for complete basal and dynamic endocrine lab tests and glucose metabolism...
November 29, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29198141/association-between-plantar-fasciitis-and-isolated-gastrocnemius-tightness
#5
Ngenomeulu T Nakale, Andrew Strydom, Nick P Saragas, Paulo N F Ferrao
BACKGROUND: An association between plantar fasciitis and isolated gastrocnemius tightness (IGT) has been postulated in the literature; however, there have been few studies to prove this relationship. This prospective cross-sectional cohort study was aimed at determining the association between plantar fasciitis and IGT. METHODS: Three groups comprising 45 patients with plantar fasciitis (group 1), 117 patients with foot and ankle pathology other than plantar fasciitis (group 2), and 61 patients without foot and ankle pathology (group 3) were examined for the presence of IGT using the Silfverskiöld test...
December 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29185012/systems-biology-of-the-imidia-biobank-from-organ-donors-and-pancreatectomised-patients-defines-a-novel-transcriptomic-signature-of-islets-from-individuals-with-type-2-diabetes
#6
Michele Solimena, Anke M Schulte, Lorella Marselli, Florian Ehehalt, Daniela Richter, Manuela Kleeberg, Hassan Mziaut, Klaus-Peter Knoch, Julia Parnis, Marco Bugliani, Afshan Siddiq, Anne Jörns, Frédéric Burdet, Robin Liechti, Mara Suleiman, Daniel Margerie, Farooq Syed, Marius Distler, Robert Grützmann, Enrico Petretto, Aida Moreno-Moral, Carolin Wegbrod, Anke Sönmez, Katja Pfriem, Anne Friedrich, Jörn Meinel, Claes B Wollheim, Gustavo B Baretton, Raphael Scharfmann, Everson Nogoceke, Ezio Bonifacio, Dorothée Sturm, Birgit Meyer-Puttlitz, Ugo Boggi, Hans-Detlev Saeger, Franco Filipponi, Mathias Lesche, Paolo Meda, Andreas Dahl, Leonore Wigger, Ioannis Xenarios, Mario Falchi, Bernard Thorens, Jürgen Weitz, Krister Bokvist, Sigurd Lenzen, Guy A Rutter, Philippe Froguel, Manon von Bülow, Mark Ibberson, Piero Marchetti
AIMS/HYPOTHESIS: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in Diabetes (IMIDIA) consortium ( www.imidia.org ) established a comprehensive, unique multicentre biobank of human islets and pancreas tissues from organ donors and metabolically phenotyped pancreatectomised patients (PPP)...
November 28, 2017: Diabetologia
https://www.readbyqxmd.com/read/29180325/-correlation-between-ectopic-fat-accumulation-and-insulin-sensitivity-in-obese-individuals-with-different-glucose-tolerance-levels
#7
Shui-Qing Lai, Zhen-Zhen Hong, Hong-Mei Chen, Jin-Xin Lin, Jian Kuang, Yan-Bing Li
OBJECTIVE: To investigate the correlation between liver and skeletal muscle fat contents and insulin resistance in obese individuals with different levels of glucose tolerance. METHODS: RESULTS: Ten non-obese individuals with normal glucose tolerance (NGT), 9 obese individuals with NGT, and 7 obese individuals with impaired glucose tolerance (IGT) were enrolled in this study. All the participants were examined for insulin sensitivity by hyperinsulinemic-euglycemic clamp and for liver and skeletal muscle fat accumulation quantified by proton magnetic resonance spectroscopy (1H MRS)...
November 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29179707/selective-impairment-of-decision-making-under-ambiguity-in-alexithymia
#8
Lei Zhang, Xue Wang, Yu Zhu, Hongchen Li, Chunyan Zhu, Fengqiong Yu, Kai Wang
BACKGROUND: Alexithymia is characterised by difficulties identifying and describing emotions. Few studies have investigated how alexithymia influences decision-making under different conditions (ambiguity and risk). This study aimed to examine whether alexithymia contributes to impairment in decision-making. METHOD: This study included 42 participants with high scores in the Chinese version of Toronto Alexithymia Scale (alexithymia group), and 44 matched subjects with low scores (control group)...
November 28, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29177412/prefrontal-recruitment-mitigates-risk-taking-behavior-in-hiv-infected-young-adults
#9
Robert X Smith, Anika Guha, Florin Vaida, Robert H Paul, Beau Ances
Background: HIV-infected (HIV+) young adults often engage in risk taking behavior. However, the disruptive effects of HIV on the neurobiological underpinnings of risky decision-making are not well understood. Methods: Risky decision-making, measured via the Iowa Gambling Task (IGT), was compared voxel-wise to resting cerebral blood flow (rCBF) acquired via arterial spin labeling. Separate topographical maps were obtained for HIV uninfected (HIV-; n=62) and HIV+ (n=41) young adults (18-24 years old) and were compared to the full cohort of participants...
November 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29165385/prevalence-of-pre-diabetes-across-ethnicities-a-review-of-impaired-fasting-glucose-ifg-and-impaired-glucose-tolerance-igt-for-classification-of-dysglycaemia
#10
REVIEW
Wilson C Y Yip, Ivana R Sequeira, Lindsay D Plank, Sally D Poppitt
Prediabetes can be defined by the presence of impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT), or glycated haemoglobin (HbA1c) to identify individuals at increased risk of developing type 2 diabetes (T2D). The World Health Organization (WHO, 1999) and the American Diabetes Association (ADA, 2003) utilise different cut-off values for IFG (WHO: 6.1-6.9 mmol/L; ADA: 5.6-6.9 mmol/L) but the same cut-off values for IGT (7.8-11.0 mmol/L). This review investigates whether there are differences in prevalence of IFG, IGT, and combined IFG&IGT between ethnicities, in particular Asian Chinese and European Caucasians...
November 22, 2017: Nutrients
https://www.readbyqxmd.com/read/29163238/impairment-of-working-memory-decision-making-and-executive-function-in-the-first-degree-relatives-of-people-with-panic-disorder-a-pilot-study
#11
Zhenhe Zhou, Dongjie Ni
Background: Panic disorder (PD) patients present impairments of working memory, decision-making, and executive function. However, whether the first-degree relatives (FDRs) of people with PD present abnormal characteristics, including clinical and neuropsychological aspects, in comparison to the general population, has not been studied. Investigation and understanding of the abnormal neuropsychological characteristics of the FDRs of people with PD will contribute to the prevention and treatment of PD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29162362/prediabetes-is-associated-with-lower-brain-gray-matter-volume-in-the-general-population-the-study-of-health-in-pomerania-ship
#12
M R P Markus, T Ittermann, K Wittfeld, S Schipf, U Siewert-Markus, M Bahls, R Bülow, N Werner, D Janowitz, S E Baumeister, S B Felix, M Dörr, W Rathmann, H Völzke, H J Grabe
BACKGROUND AND AIMS: We investigated the associations of fasting (FG) and 2-h postload (2HG) plasma glucose from oral glucose tolerance test (OGTT) with gray (GMV) and white (WMV) matter volume. METHODS AND RESULTS: We analyzed data from 1330 subjects without known diabetes mellitus, aged 21 to 81, from the second cohort (SHIP-Trend-0) of the population-based Study of Health in Pomerania (SHIP). Following the OGTT, individuals were classified in five groups (according to the American Diabetes Association criteria): normal glucose tolerance (NGT), isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), combined IFG and IGT (IFG + IGT) and unknown type 2 diabetes mellitus (UDM)...
December 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29161407/myonectin-predicts-the-development-of-type-2-diabetes
#13
Kejia Li, Xin Liao, Kuan Wang, Qiao Mi, Tingran Zhang, Yanjun Jia, Xiaohuei Xu, Xiaoheu Luo, Cheng Zhang, Hua Liu, Hongting Zhen, Ling Li, Gangyi Yang
Context: Myonectin has been identified as a novel myokine expressed predominantly in skeletal muscle. However, its clinical implications are largely unknown. Objective: The aim of this study is to investigate the relationship between myonectin (CTRP15) and T2DM in cross-sectional and interventional studies. Patients and Design: 104 newly diagnosed T2DM patients (nT2DM), 109 IGT and 128 healthy individuals were recruited for this study. In a separate study, OGTT, a 45-min bout of exercise, lipid infusions and EHC were performed to investigate the association of myonectin with IR and T2DM...
November 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29155153/the-glp-1-response-to-glucose-does-not-mediate-beta-and-alpha-cell-dysfunction-in-hispanics-with-abnormal-glucose-metabolism
#14
Elizabeth Adams, Pauline Genter, Emma Keefe, Kevin Sandow, Virginia Gray, Jerome I Rotter, Yii-Der Ida Chen, Eli Ipp
AIMS: Glucagon-like peptide-1 (GLP-1) contributes to insulin secretion after meals. Though Hispanics have increased risk for type 2 diabetes mellitus, it is unknown if impaired GLP-1 secretion contributes to this risk. We therefore studied plasma GLP-1 secretion and action in Hispanic adults. METHODS: Hispanic (H; n=31) and non-Hispanic (nH; n=15) participants underwent an oral glucose tolerance test (OGTT). All participants were categorized by glucose tolerance into four groups: normal glucose tolerant non-Hispanic (NGT-nH; n = 15), normal glucose tolerant Hispanic (NGT-H; n = 12), impaired glucose tolerant Hispanic (IGT-H; n = 11), or newly diagnosed type 2 diabetes mellitus, Hispanic (T2D-H; n = 8)...
November 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29154644/a-longitudinal-analysis-of-adolescent-decision-making-with-the-iowa-gambling-task
#15
Brandon Almy, Michael Kuskowski, Stephen M Malone, Evan Myers, Monica Luciana
Many researchers have used the standard Iowa Gambling Task (IGT) to assess decision-making in adolescence given increased risk-taking during this developmental period. Most studies are cross-sectional and do not observe behavioral trajectories over time, limiting interpretation. This longitudinal study investigated healthy adolescents' and young adults' IGT performance across a 10-year span. A total of 189 individuals (aged 9-23 at baseline) completed a baseline session and were followed at 2-year intervals yielding 5 time-points...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29151224/the-potential-role-of-the-osteopontin-osteocalcin-osteoprotegerin-triad-in-the-pathogenesis-of-prediabetes-in-humans
#16
Giuseppe Daniele, Deidre Winnier, Andrea Mari, Jan Bruder, Marcel Fourcaudot, Zuo Pengou, Andrea Hansis-Diarte, Christopher Jenkinson, Devjit Tripathy, Franco Folli
AIMS: To examine the relationship between hormones involved in bone remodeling and glucose metabolism alterations in prediabetes. METHODS: Individuals (n = 43) with NGT (BMI = 31.1 ± 1.1 kg/m(2)) and individuals (n = 79) with impaired glucose regulation (IGR) (BMI = 31.9 ± 1.2 kg/m(2)) including subjects with IFG, IGT, and IFG-IGT underwent OGTT and DXA. Osteopontin (OPN), osteocalcin (OCN), osteoprotegerin (OPG), and PTH levels were measured at fasting...
November 18, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29144805/dpp4-inhibitor-sitagliptin-as-a-potential-treatment-option-in-metformin-intolerant-obese-women-with-polycystic-ovary-syndrome-a-pilot-randomized-study
#17
Simona Ferjan, Andrej Janez, Mojca Jensterle
OBJECTIVE: Metformin has an established role in the management of polycystic ovary syndrome (PCOS). Some patients cannot tolerate it due to associated gastrointestinal adverse events. The present study evaluated DPP4 inhibitor sitagliptin as a potential treatment option in metformin intolerant PCOS. DESIGN: We conducted a 12-week prospective randomized open-label study with 30 obese metformin intolerant women with PCOS (aged 35.0±7.2 years, BMI 36.9±5.5 kg/m(2))...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29135438/exposure-to-perfluoroalkyl-substances-and-metabolic-outcomes-in-pregnant-women-evidence-from-the-spanish-inma-birth-cohorts
#18
Nuria Matilla-Santander, Damaskini Valvi, Maria-Jose Lopez-Espinosa, Cyntia B Manzano-Salgado, Ferran Ballester, Jesús Ibarluzea, Loreto Santa-Marina, Thomas Schettgen, Mònica Guxens, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy is a period of enhanced tissue plasticity for the fetus and the mother and may be a critical window of PFAS exposure susceptibility. OBJECTIVE: We evaluated the associations between PFAS exposures and metabolic outcomes in pregnant women. METHODS: We analyzed 1,240 pregnant women from the Spanish INMA [Environment and Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with measured first pregnancy trimester plasma concentrations of four PFASs (in nanograms/milliliter)...
November 13, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29129114/image-guided-surgery-and-therapy-for-lung-cancer-a-critical-review
#19
Keyvan Moghissi, Kate Dixon
Of the many imaging technologies, some have the potential to be used in image-guided surgery and therapy (IGS/IGT). This review of relevant papers on IGS/IGT for lung cancer indicates effective localization and IGS/IGT in early endobronchial lesions by fluorescence bronchoscopic technique. Visualization of early peripheral (nodular) tumors at operation can be achieved by a variety of imaging methods and devices which allow identification, localization and provision of intraoperative real-time images. Recent developments employing fluorescence contrasts and near infra-red light have shown encouraging feasibility and outcome in providing reliable methods for the IGS of cancer generally and lung cancer more specifically with provision of real time intraoperative imaging...
November 13, 2017: Future Oncology
https://www.readbyqxmd.com/read/29127425/the-effects-of-vitamin-e-or-lipoic-acid-supplementation-on-oxyphytosterols-in-subjects-with-elevated-oxidative-stress-a-randomized-trial
#20
Sabine Baumgartner, Ronald P Mensink, Guido R Haenen, Aalt Bast, Christoph J Binder, Otto Bekers, Constanze Husche, Dieter Lütjohann, Jogchum Plat
Despite increased serum plant sterol concentrations after consumption of plant sterol enriched margarines, plasma oxyphytosterol concentrations were not increased in healthy subjects. Here, we assessed plasma oxyphytosterol concentrations and whether they are affected by antioxidants in subjects with elevated oxidative stress. Twenty subjects with impaired glucose tolerance (IGT) or type 2 diabetes (DM2) consumed for 4 weeks placebo, vitamin E (804 mg/d) or lipoic acid capsules (600 mg/d). Plasma and blood cell oxyphytosterol and oxycholesterol concentrations were determined in butylated hydroxytoluene-enriched EDTA plasma via GC-MS...
November 10, 2017: Scientific Reports
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