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https://www.readbyqxmd.com/read/29467922/type-2-diabetes-epidemic-in-east-asia-a-35-year-systematic-trend-analysis
#1
Huiping Yuan, Xinghui Li, Gang Wan, Liang Sun, Xiaoquan Zhu, Fugang Che, Ze Yang
Facing the challenge of effective prevention type 2 diabetes (T2DM) in China (as part of global health) requires knowledge about both the temporal trend and risk factors variation in T2DM. We searched the PubMed, CNKI, WANFANG, and International Diabetes Federation (IDF) databases for data on the prevalence of T2DM/ IGT (impaired glucose tolerance) published from January 1, 1980 to December 31, 2014 in China, Japan and Korea. The prevalence of T2DM was estimated with 95% confidence intervals (CIs) using random-effects meta-analysis...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29460080/heterogeneity-of-gestational-diabetes-gdm-and-long-term-risk-of-diabetes-and-metabolic-syndrome-findings-from-the-radiel-study-follow-up
#2
Emilia Huvinen, Johan G Eriksson, Saila B Koivusalo, Nora Grotenfelt, Aila Tiitinen, Beata Stach-Lempinen, Kristiina Rönö
AIMS: To assess the metabolic health of obese and non-obese women at high GDM risk 5 years postpartum. METHODS: This is a secondary analysis of the 5-year follow-up of the RADIEL GDM prevention study including 333 women at high GDM risk (BMI ≥ 30 kg/m2 and/or previous GDM). Five years postpartum metabolic health was assessed including anthropometric measurements, oral glucose tolerance test, lipid metabolism, and body composition as well as medical history questionnaires...
February 19, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29455547/evaluation-of-fractalkine-fkn-and-secreted-frizzled-related-protein-4-sfrp-4-serum-levels-in-patients-with-prediabetes-and-type-2-diabetes
#3
S Baldane, S H Ipekci, A Ekin, S Abusoglu, A Unlu, L Kebapcilar
OBJECTIVE: The objective of this study is to compare serum levels of FKN and SFRP-4 in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM). METHODS: A total of 152 patients presented to the endocrinology outpatient clinic of our hospital were included in the study. Eighty-two patients with a history of T2DM were assigned to the T2DM group. IGT (n = 34) and NGT (n = 36) groups included the patients who received oral glucose tolerance test outcomes...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29439501/the-roles-of-mitochondrion-in-intergenomic-gene-transfer-in-plants-a-source-and-a-pool
#4
Nan Zhao, Yumei Wang, Jinping Hua
Intergenomic gene transfer (IGT) is continuous in the evolutionary history of plants. In this field, most studies concentrate on a few related species. Here, we look at IGT from a broader evolutionary perspective, using 24 plants. We discover many IGT events by assessing the data from nuclear, mitochondrial and chloroplast genomes. Thus, we summarize the two roles of the mitochondrion: a source and a pool. That is, the mitochondrion gives massive sequences and integrates nuclear transposons and chloroplast tRNA genes...
February 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29436377/elevated-medium-chain-acylcarnitines-are-associated-with-gestational-diabetes-and-early-progression-to-type-2-diabetes-and-induce-pancreatic-%C3%AE-cell-dysfunction
#5
Battsetseg Batchuluun, Dana Al Rijjal, Kacey J Prentice, Judith A Eversley, Elena Burdett, Haneesha Mohan, Alpana Bhattacharjee, Erica P Gunderson, Ying Liu, Michael B Wheeler
Specific circulating metabolites have emerged as important risk factors for the development of diabetes. The acylcarnitines (acylCs) are a family of metabolites known to be elevated in type-2 diabetes (T2D) and linked to peripheral insulin resistance. However, the impact of AcylCs on pancreatic β-cell function is not well understood. Here, we profiled circulating acylCs in two diabetes cohorts: 1) women with gestational diabetes (GDM) and 2) women with recent GDM who later developed impaired glucose tolerance (IGT), new-onset T2D or returned to normoglycemia within a two-year follow-up period...
February 7, 2018: Diabetes
https://www.readbyqxmd.com/read/29432659/relationship-between-serum-adipsin-and-first-phase-of-glucose-stimulated-insulin-secretion-in-subjects-with-different-glucose-tolerance
#6
Qing Zhou, Qian Ge, Yao Ding, Hua Qu, Huili Wei, Rui Wu, Lu Yao, Qianping Wei, Zhengping Feng, Jian Long, Huacong Deng
AIMS: To detect serum adipsin levels in subjects with different glucose tolerance and investigate the relationship between adipsin and first-phase of insulin secretion. METHODS: 56 patients with newly diagnosed type 2 diabetes mellitus(T2DM), 36 patients with impaired glucose tolerance (IGT), and 45 subjects with normal glucose tolerance (NGT) were enrolled. Intravenous glucose tolerance tests were performed to evaluate pancreatic β cell function. The serum levels of adipsin, interleukin 1β (IL-1β), hypersensitive C Reactive Protein (hs-CRP) were assayed...
February 12, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29428063/integrated-model-of-insulin-and-glucose-kinetics-describing-both-hepatic-glucose-and-pancreatic-insulin-regulation
#7
Mogens Erlandsen, Christoffer Martinussen, Claus Højbjerg Gravholt
BACKGROUND AND OBJECTIVES: Modeling of glucose kinetics has to a large extent been based on models with plasma insulin as a known forcing function. Furthermore, population-based statistical methods for parameter estimation in these models have mainly addressed random inter-individual variations and not intra-individual variations in the parameters. Here we present an integrated whole-body model of glucose and insulin kinetics which extends the well-known two-compartment glucose minimal model...
March 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29397342/high-frequency-of-type-2-diabetes-and-impaired-glucose-tolerance-in-japanese-subjects-with-the-angiopoietin-like-protein-8-r59w-variant
#8
Jianhui Liu, Kunimasa Yagi, Atsushi Nohara, Daisuke Chujo, Azusa Ohbatake, Aya Fujimoto, Yukiko Miyamoto, Junji Kobayashi, Masakazu Yamagishi
BACKGROUND: Angiopoietin-like protein 8 (ANGPTL8) is considered to be metabolically multifunctional. One notable function still to be elucidated definitively is a betatrophic role in protecting and preserving pancreatic beta-cell function. There is, however, a paucity of data regarding the role of ANGPTL8 in the etiology of type 2 diabetes (T2D), but some findings of human research have suggested the potential for significant involvement. OBJECTIVE: To examine the frequency of T2D and impaired glucose tolerance (IGT) in Japanese subjects with the ANGPTL8 R59W variant...
December 29, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29396374/efficacy-of-vildagliptin-for-prevention-of-postpartum-diabetes-in-women-with-a-recent-history-of-insulin-requiring-gestational-diabetes-a-phase-ii-randomized-double-blind-placebo-controlled-study
#9
Sandra Hummel, Andreas Beyerlein, Markus Pfirrmann, Anna Hofelich, Daniela Much, Susanne Hivner, Melanie Bunk, Melanie Herbst, Claudia Peplow, Markus Walter, Denise Kohn, Nadine Hummel, Jürgen Kratzsch, Michael Hummel, Martin Füchtenbusch, Joerg Hasford, Anette-G Ziegler
OBJECTIVE: Women with insulin-requiring gestational diabetes mellitus (GDM) are at high risk of developing diabetes within a few years postpartum. We implemented this phase II study to test the hypothesis that vildagliptin, a dipeptidyl peptidase-4 inhibitor, is superior to placebo in terms of reducing the risk of postpartum diabetes. METHODS: Women with insulin-requiring GDM were randomized to either placebo or 50 mg vildagliptin twice daily for 24 months followed by a 12-month observation period (EudraCT: 2007-000634-39)...
January 3, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29378576/economic-evaluation-of-type-2-diabetes-prevention-programmes-markov-model-of-low-and-high-intensity-lifestyle-programmes-and-metformin-in-participants-with-different-categories-of-intermediate-hyperglycaemia
#10
Samantha Roberts, Dawn Craig, Amanda Adler, Klim McPherson, Trisha Greenhalgh
BACKGROUND: National guidance on preventing type 2 diabetes mellitus (T2DM) in the UK recommends low-intensity lifestyle interventions for individuals with intermediate categories of hyperglycaemia defined in terms of impaired fasting glucose (IFG) or 'at-risk' levels of HbA1c. In a recent systematic review of economic evaluations of such interventions, most studies had evaluated intensive trial-based lifestyle programmes in participants with impaired glucose tolerance (IGT). This study examines the costs and effects of different intensity lifestyle programmes and metformin in participants with different categories of intermediate hyperglycaemia...
January 30, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29368616/undetected-dysglycaemia-common-in-primary-care-patients-treated-for-hypertension-and-or-dyslipidaemia-on-the-need-for-a-screening-strategy-in-clinical-practice-a-report-from-euroaspire-iv-a-registry-from-the-euroobservational-research-programme-of-the-european
#11
Bahira Shahim, Viveca Gyberg, Dirk De Bacquer, Kornelia Kotseva, Guy De Backer, Oliver Schnell, Jaakko Tuomilehto, David Wood, Lars Rydén
BACKGROUND: Dysglycaemia defined as type 2 diabetes (T2DM) and impaired glucose tolerance (IGT), increases the risk of cardiovascular disease (CVD). The negative impact is more apparent in the presence of hypertension and/or dyslipidaemia. Thus, it seems reasonable to screen for dysglycaemia in patients treated for hypertension and/or dyslipidaemia. A simple screening algorithm would enhance the adoption of such strategy in clinical practice. OBJECTIVES: To test the hypotheses (1) that dysglycaemia is common in patients with hypertension and/or dyslipidaemia and (2) that initial screening with the Finnish Diabetes Risk Score (FINDRISC) will decrease the need for laboratory based tests...
January 24, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29364890/5-aminolevulinic-acid-ala-deficiency-causes-impaired-glucose-tolerance-and-insulin-resistance-coincident-with-an-attenuation-of-mitochondrial-function-in-aged-mice
#12
Shinichi Saitoh, Satoshi Okano, Hidekazu Nohara, Hiroshi Nakano, Nobuyuki Shirasawa, Akira Naito, Masayuki Yamamoto, Vincent P Kelly, Kiwamu Takahashi, Tohru Tanaka, Motowo Nakajima, Osamu Nakajima
In vertebrates, the initial step in heme biosynthesis is the production of 5-aminolevulinic acid (ALA) by ALA synthase (ALAS). ALA formation is believed to be the rate-limiting step for cellular heme production. Recently, several cohort studies have demonstrated the potential of ALA as a treatment for individuals with prediabetes and type-2 diabetes mellitus. These studies imply that a mechanism exists by which ALA or heme can control glucose metabolism. The ALAS1 gene encodes a ubiquitously expressed isozyme...
2018: PloS One
https://www.readbyqxmd.com/read/29358036/descriptive-epidemiology-of-metabolic-syndrome-among-obese-adolescent-population
#13
Sharmin Mahbuba, Fauzia Mohsin, Farhana Rahat, Jebun Nahar, Tahmina Begum, Nazmun Nahar
AIMS: The study was done to assess the magnitude of problems of metabolic syndrome among obese adolescents. MATERIALS AND METHOD: It was a cross-sectional study done from January 2013 to June 2014 in paediatric endocrine outpatient department in BIRDEM General Hospital, Dhaka, Bangladesh. Total 172 adolescents having exogenous obesity aged 10-18 years were included. Impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (DM) were defined as per WHO criteria...
January 4, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29354930/-skin-needle-embedding-for-obese-impaired-glucose-tolerance
#14
Jinghua Liang, Zhendi Feng, Shengkui Feng, Shude Bao, Kejia Wang
OBJECTIVE: To explore the effect difference between the skin needle embedding therapy and western medication for obese impaired glucose tolerance (IGT). METHODS: A total of 300 cases of obese IGT were assigned into an embedding group and a western medication group by random number table, 150 cases in each one. Standardized diagnosis and treatment programs were applied to reduce blood pressure, lipid, weight, and exercise and scientific diet management were used...
January 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29354901/-effects-of-laparoscopic-sleeve-gastrectomy-on-insulin-secretion-patterns-in-morbidly-obese-patients
#15
Chunhua Qian, Cuiling Zhu, Jingyang Gao, Le Bu, Donglei Zhou, Ning Li, Shen Qu
OBJECTIVE: To assess the effects of laparoscopic sleeve gastrectomy (LSG) on insulin secretion mode and metabolism of glucose and lipid in morbidly obese patients. METHODS: Clinical data of 65 morbidly obese patients [body mass index (BMI) ≥30 kg/m2] undergoing LSG at Shanghai 10th People's Hospital from August 2012 to December 2016 were retrospectively analyzed. According to the result of OGTT, these obese patients were divided into three groups: normal glucose tolerance (NGT, 23 cases), impaired glucose tolerance (IGT, 22 cases) and type 2 diabetes mellitus (DM, 20 cases) groups...
January 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29353417/maternal-metabolic-response-to-dietary-treatment-for-impaired-glucose-tolerance-and-gestational-diabetes-mellitus
#16
Karen L Lindsay, Lorraine Brennan, Maria A Kennelly, Sinéad Curran, Mary Coffey, Thomas P Smith, Michael E Foley, Mensud Hatunic, Fionnuala M McAuliffe
BACKGROUND: Dietary advice is a standard component of treatment for pregnant women with impaired glucose tolerance (IGT) and gestational diabetes (GDM), yet few studies report glycemic profiles in response to dietary therapies and the optimal dietary approach remains uncertain. AIM: To assess changes in maternal glycemic profile and pregnancy outcomes among women with diet-controlled IGT and GDM. METHODS: Pregnant women who had one or more elevated values on a 3-h oral glucose tolerance test were enrolled...
January 20, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29351480/mechanistically-different-effects-of-fat-and-sugar-on-insulin-resistance-hypertension-and-gut-microbiota-in-rats
#17
Sara Ramos-Romero, Mercè Hereu, Lidia Atienza, Josefina Casas, Olga Jáuregui, Susana Amézqueta, Gabriel Dasilva, Isabel Medina, Maria Rosa Nogués, Marta Romeu, Josep Lluís Torres
Insulin resistance (IR) and impaired glucose tolerance (IGT) are the first manifestations of diet-induced metabolic alterations leading to type-2 diabetes, while hypertension is the deadliest risk factor of cardiovascular disease. The roles of dietary fat and fructose in the development of IR, IGT and hypertension are controversial. We tested the long-term effects of an excess of fat or sucrose (fructose/glucose) on healthy male Wistar Kyoto (WKY) rats. Fat affects IR and IGT earlier than fructose through low-grade systemic inflammation evidenced by liver inflammatory infiltration, increased levels of plasma interleukin-6, prostaglandin E2 and reduced levels of protective short-chain fatty acids without triggering hypertension...
January 2, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29348840/the-prevalence-of-and-risk-factors-for-diabetes-mellitus-and-impaired-glucose-tolerance-among-tibetans-in-china-a-cross-sectional-study
#18
Shaopeng Xu, Qing Wang, Jie Liu, Bo Bian, Xuefang Yu, Xiangdong Yu, Xianjia Ning, Jinghua Wang
The prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) has increased worldwide, although their prevalence and determinants among Tibetans are currently unknown. We thus aimed to explore the prevalence of and risk factors for DM and IGT among Tibetans in China. In 2011, 1659 Tibetan adults (aged ≥ 18 years) from Changdu, China, were recruited to this cross-sectional study. They completed a questionnaire and underwent physical examinations and laboratory testing to assess risk factors for DM and IGT...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29337019/prediabetes-is-associated-with-microalbuminuria-reduced-kidney-function-and-chronic-kidney-disease-in-the-general-population-the-kora-cooperative-health-research-in-the-augsburg-region-f4-study
#19
M R P Markus, T Ittermann, S E Baumeister, C Huth, B Thorand, C Herder, M Roden, U Siewert-Markus, W Rathmann, W Koenig, M Dörr, H Völzke, S Schipf, C Meisinger
BACKGROUND AND AIMS: We investigated the associations of serum fasting (FG) and 2-h postload (2HG) glucose from an oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), fasting insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) with urinary albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR). METHODS AND RESULTS: We performed cross-sectional analyses of 2713 subjects (1429 women; 52.7%) without known type 2 diabetes, aged 31-82 years, from the KORA (Cooperative Health Research in the Augsburg Region) F4-Study...
December 22, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29332012/classical-adiponectin-leptin-resistin-and-new-chemerin-vaspin-omentin-adipocytokines-in-patients-with-prediabetes
#20
Antoaneta Gateva, Yavor Assyov, Adelina Tsakova, Zdravko Kamenov
Background In the last decade, there has been an increased interest toward fat tissue as an endocrine organ that secretes many cytokines and bioactive mediators that play a role in insulin sensitivity, inflammation, coagulation and the pathogenesis of atherosclerosis. The aim of this study was to investigate classical (adiponectin, leptin, resistin) and new (chemerin, vaspin, omentin) adipocytokine levels in subjects with prediabetes [impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT)] and obese subjects with normoglycemia...
January 15, 2018: Hormone Molecular Biology and Clinical Investigation
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