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https://www.readbyqxmd.com/read/28529949/microrna-expression-varies-according-to-glucose-tolerance-measurement-platform-and-biological-source
#1
S Dias, S Hemmings, C Muller, J Louw, C Pheiffer
Dysregulated microRNA (miRNA) expression is observed during type 2 diabetes (T2D), although the consistency of miRNA expression across measurement platform and biological source is uncertain. Here we report miRNA profiling in the whole blood and serum of South African women with different levels of glucose tolerance, using next generation sequencing (NGS) and quantitative real time PCR (qRT-PCR). Whole blood-derived miRNAs from women with newly diagnosed T2D (n = 4), impaired glucose tolerance (IGT) (n = 4), and normal glucose tolerance (NGT) (n = 4) were subjected to NGS, whereafter transcript levels of selected miRNAs were quantified in the whole blood and serum of these women using qRT-PCR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28516806/is-bisphenol-a-exposure-associated-with-the-development-of-glucose-intolerance-and-increased-insulin-resistance-in-thais
#2
La-Or Chailurkit, Pechngam Tengpraettanakorn, Suwannee Chanprasertyotin, Boonsong Ongphiphadhanakul
Bisphenol A (BPA), the monomeric component of polycarbonate plastics, reportedly possesses endocrine-disrupting effects. Exposure to low levels of BPA during more vulnerable periods leads to abnormalities related to sexual development in experimental animals. Moreover, recently a few epidemiological studies in Caucasians have demonstrated the association of BPA exposure with type 2 diabetes. Therefore, in the present study we examined the association of BPA exposure and abnormal glucose tolerance in Thais. This is a cross-sectional study of 240 participants aged at least 50 years, randomly selected by computer-generated random numbers within each glucose tolerance status from an oral glucose tolerance study of 661 participants...
January 1, 2017: Nutrition and Health
https://www.readbyqxmd.com/read/28513068/a-randomized-controlled-trial-branched-chain-amino-acid-levels-and-glucose-metabolism-in-patients-with-obesity-and-sleep-apnea
#3
Antonia Barceló, Daniel Morell-Garcia, Neus Salord, Cristina Esquinas, Gerardo Pérez, Antonio Pérez, Carmen Monasterio, Merce Gasa, Ana Maria Fortuna, Josep Maria Montserrat, Mercedes Mayos
There is evidence that changes in branched-chain amino acid (BCAA) levels may correlate with the efficacy of therapeutic interventions for affecting improvement in metabolic control. The objective of this study was to evaluate whether serum concentrations of BCAAs (leucine, isoleucine, valine) could mediate in insulin sensitivity and glucose tolerance after continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea (OSA). A prospective randomized controlled trial of OSA patients with morbid obesity was conducted...
May 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28503277/prevalence-of-diabetes-impaired-fasting-glucose-and-impaired-glucose-tolerance-in-patients-with-thalassemia-major-in-iran-a-meta-analysis-study
#4
REVIEW
Milad Azami, Ali Sharifi, Siros Norozi, Akram Mansouri, Kourosh Sayehmiri
BACKGROUND: This study aimed to investigate the prevalence of diabetes, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) in Iranian patients with thalassemia major. METHODS: The current study has been conducted based on PRISMA guideline. To obtain the documents, Persian and English scientific databases such as Magiran, Iranmedex, SID, Medlib, IranDoc, Scopus, PubMed, ScienceDirect, Cochrane, Web of Science, Springer, Wiley Online Library as well as Google Scholar were searched until December 2015...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28494269/medical-conditions-associated-with-recurrent-miscarriage-is-bmi-the-tip-of-the-iceberg
#5
Mushi J Matjila, Anne Hoffman, Zephne M van der Spuy
BACKGROUND: In contrast to sporadic miscarriage, recurrent miscarriage (RM) is a rare entity which affects 1% of couples attempting conception. It is distressing for couples and healthcare professionals as the aetiology is unclear with limited treatment options. Apart from anti-phospholipid syndrome (APS), the strength of associations between RM and commonly investigated endocrine, autoimmune, thrombophilic and uterine structural abnormalities remains uncertain and variable. OBJECTIVES: To assess the prevalence of commonly investigated medical conditions associated with RM...
May 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28493887/effect-of-lifestyle-interventions-on-cardiovascular-risk-factors-among-adults-without-impaired-glucose-tolerance-or-diabetes-a-systematic-review-and-meta-analysis
#6
Xuanping Zhang, Heather M Devlin, Bryce Smith, Giuseppina Imperatore, William Thomas, Felipe Lobelo, Mohammed K Ali, Keri Norris, Stephanie Gruss, Barbara Bardenheier, Pyone Cho, Isabel Garcia de Quevedo, Uma Mudaliar, Christopher D Jones, Jeffrey M Durthaler, Jinan Saaddine, Linda S Geiss, Edward W Gregg
Structured lifestyle interventions can reduce diabetes incidence and cardiovascular disease (CVD) risk among persons with impaired glucose tolerance (IGT), but it is unclear whether they should be implemented among persons without IGT. We conducted a systematic review and meta-analyses to assess the effectiveness of lifestyle interventions on CVD risk among adults without IGT or diabetes. We systematically searched MEDLINE, EMBASE, CINAHL, Web of Science, the Cochrane Library, and PsychInfo databases, from inception to May 4, 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28487510/influence-of-depression-on-genetic-predisposition-to-type-2-diabetes-in-a-multiethnic-longitudinal-study
#7
Sophiya Garasia, Zainab Samaan, Hertzel C Gerstein, James C Engert, Viswanathan Mohan, Rafael Diaz, Sonia S Anand, David Meyre
We assessed the association between depression status and prevalent and incident type 2 diabetes (T2D) as well as the interaction between depression and a genetic risk score (GS) based on 20 T2D single-nucleotide polymorphisms (SNPs) in a multi-ethnic longitudinal study. We studied 17,375 participants at risk for dysglycemia. All participants had genotypic and phenotypic data collected at baseline and 9,930 participants were followed-up for a median of 3.3 years. Normal glucose tolerance (NGT), impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) and T2D statuses were determined using an oral glucose tolerance test and the 2003 American Diabetes Association criteria...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28479345/a-bcwd-resistant-line-of-rainbow-trout-exhibits-higher-abundance-of-igt-b-cells-and-heavy-chain-tau-transcripts-compared-to-a-susceptible-line-following-challenge-with-flavobacterium-psychrophilum
#8
Patty Zwollo, Erin Hennessey, Catherine Moore, David P Marancik, Gregory D Wiens, Lidia Epp
Bacterial Cold Water Disease (BCWD) is a common, chronic disease in rainbow trout, and is caused by the gram-negative bacterium Flavobacterium psychrophilum (Fp). Through selective breeding, the National Center for Cool and Cold Water Aquaculture has generated a genetic line that is highly resistant to Fp challenge, designated ARS-Fp-R (or R-line), as well as a susceptible "control" line, ARS-Fp-S (S-line). In previous studies, resistance to Fp had been shown to correlate with naive animal spleen size, and further, naïve R-line trout had been shown to have a lower abundance of IgM(+) and IgM(++) cells compared to S-line fish...
May 4, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28479343/oral-dna-vaccines-based-on-cs-tpp-nanoparticles-and-alginate-microparticles-confer-high-protection-against-infectious-pancreatic-necrosis-virus-ipnv-infection-in-trout
#9
Sohrab Ahmadivand, Mehdi Soltani, Mahdi Behdani, Øystein Evensen, Ehsan Alirahimi, Reza Hassanzadeh, Ellahe Soltani
Infectious pancreatic necrosis virus (IPNV) is the etiological agent of a contagious viral disease causing remarkable mortalities in different fish species. Despite the availability of commercial vaccines against IPN, the disease still constitutes one of the main threats to the aquaculture industry worldwide. In this study, we developed a DNA vaccine encoding the VP2 gene of IPNV and evaluated its ability to induce protective immunity in rainbow trout fry (3 g) at doses of 10 and 25 μg/fish and boosting with the same doses two weeks later through the oral route using chitosan/tripolyphosphate (CS-TPP) nanoparticles and alginate microparticles incorporated into fish feed...
May 4, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28475942/distinct-cognitive-performance-and-patterns-of-drug-use-among-early-and-late-onset-cocaine-users
#10
Bruna Mayara Lopes, Priscila Dib Gonçalves, Mariella Ometto, Bernardo Dos Santos, Mikael Cavallet, Tiffany Moukbel Chaim-Avancini, Mauricio Henriques Serpa, Sergio Nicastri, André Malbergier, Geraldo F Busatto, Arthur Guerra de Andrade, Paulo Jannuzzi Cunha
INTRODUCTION: Adolescence is a crucial period for neurodevelopment, but few studies have investigated the impact of early cocaine use on cognitive performance and patterns of substance use. METHODS: We evaluated 103 cocaine dependent inpatients divided in two groups: early-onset users (EOG; n=52), late-onset users (LOG; n=51), and 63 healthy controls. Neuropsychological functioning was evaluated using Digits Forward (DF) and Backward (DB), Trail Making Test (TMT), Stroop Color Word Test (SCWT), Controlled Oral Word Association Test (COWAT), Wisconsin Card Sorting Test (WCST), Rey Osterrieth Complex Figure Test (ROCFT), Frontal Assessment Battery (FAB), and Iowa Gambling Test (IGT)...
April 29, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28468647/detecting-rna-rna-interactions-in-e-coli-using-a-modified-clash-method
#11
Tao Liu, Kaiyu Zhang, Song Xu, Zheng Wang, Hanjiang Fu, Baolei Tian, Xiaofei Zheng, Wuju Li
BACKGROUND: Bacterial small regulatory RNAs (sRNAs) play important roles in sensing environment changes through sRNA-target mRNA interactions. However, the current strategy for detecting sRNA-mRNA interactions usually combines bioinformatics prediction and experimental verification, which is hampered by low prediction accuracy and low-throughput. Additionally, among the 4736 sequenced bacterial genomes, only about 2164 sRNAs from 319 strains have been described. Furthermore, target mRNAs of only 157 sRNAs have been uncovered...
May 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28465658/impact-of-obesity-with-impaired-glucose-tolerance-on-retinal-degeneration-in-a-rat-model-of-metabolic-syndrome
#12
Kishore Kumar Godisela, Singareddy Sreenivasa Reddy, Chekkilla Uday Kumar, Natarajan Saravanan, Paduru Yadagiri Reddy, Monica M Jablonski, Radha Ayyagari, Geereddy Bhanuprakash Reddy
PURPOSE: Metabolic syndrome (MetS) is associated with several degenerative diseases, including retinal degeneration. Previously, we reported on progressive retinal degeneration in a spontaneous obese rat (WNIN/Ob) model. In this study, we investigated the additional effect of impaired glucose tolerance (IGT), an essential component of MetS, on retinal degeneration using the WNIN/GR-Ob rat model. METHODS: The retinal morphology and ultrastructure of WNIN/GR-Ob and age-matched littermate lean rats were studied by microscopy and immunohistochemistry...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28459031/occurrence-of-diabetes-mellitus-in-obese-nondiabetic-patients-with-correlative-analysis-of-visceral-fat-fasting-insulin-and-insulin-resistance-a-3-year-follow-up-study-mysore-visceral-adiposity-in-diabetes-follow-up-study
#13
M Premanath, H Basavanagowdappa, M Mahesh, M Suresh Babu
OBJECTIVE: To assess the occurrence of diabetes in obese nondiabetic patients over a 3-year follow-up period with a correlative analysis of visceral fat (VF), fasting insulin levels, (FILs) and insulin resistance (IR). MATERIAL AND METHODS: Thirty-seven obese and nineteen nonobese nondiabetics of our previous study, Mysore Visceral Adiposity in Diabetes were followed for the next 3 years. Their blood pressure, body mass index, waist circumference (WC), fasting blood sugar (FBS), FIL, lipid profile and subcutaneous fat (SCF), and VF measurement by US method were repeated every 6 months for the next 3 years...
March 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28453197/peers-increase-late-adolescents-exploratory-behavior-and-sensitivity-to-positive-and-negative-feedback
#14
Karol Silva, Elizabeth P Shulman, Jason Chein, Laurence Steinberg
Adolescents take more risks with peers than when alone. It is not clear how peer presence affects adolescents' risky decision making, however. We used the Iowa Gambling Task (IGT)-a game used to assess decision making involving risk and reward-to examine how peers affect late adolescents' exploration of relevant environmental cues, ability to learn from the outcomes (positive and negative) of that exploration, and ability to integrate feedback to adjust behavior toward optimal long-term outcomes. One hundred and one 18- to 22-year old males (M = 19...
December 2016: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28436739/prediabetes-exhibits-decreased-disposition-index-correlated-with-deterioration-of-glycemic-parameters-in-nonobese-japanese-subjects-a-cross-sectional-study-from-medical-examination
#15
Yasutaka Takeda, Yukihiro Fujita, Tsuyoshi Yanagimachi, Jun Honjo, Atsuko Abiko, Mahito Asai, Masakazu Haneda
BACKGROUND: Prediabetes, defined as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), likely develops to type 2 diabetes mellitus (DM) and independently increases cardiovascular risk. We employed disposition index (DI), a new metabolic parameter indicating the pancreatic beta cell function adjusted for insulin resistance, and investigated whether it could be altered in Japanese population with prediabetes and associated with early glucose intolerance. METHODS: A total of 102 adults who underwent an oral glucose tolerance test at the medical screening were designated to normal glucose tolerance (NGT), IFG, IGT, and DM...
April 24, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28430836/test-retest-reliability-of-common-behavioral-decision-making-tasks
#16
Melissa T Buelow, Wesley R Barnhart
Objective: To examine test-retest reliability of common behavioral decision making tasks. Method: A total of 98 undergraduate students completed two administrations of the Iowa Gambling Task (IGT), Balloon Analogue Risk Task (BART), Columbia Card Task (CCT), and Game of Dice Task (GDT), three weeks apart. Results: The BART, CCT, and GDT showed moderately strong correlations across time. On the IGT, no correlations were seen between Time 1 Trials 1-40 and Time 2 performance; however, weak correlations were observed between Time 1 Trials 41-100 and Time 2 performance...
April 20, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28429468/decision-making-in-obesity-without-eating-disorders-a-systematic-review-and-meta-analysis-of-iowa-gambling-task-performances
#17
REVIEW
J-Y Rotge, C Poitou, P Fossati, J Aron-Wisnewsky, J-M Oppert
BACKGROUND: There is evidence that obesity is associated with impairments in executive functions, such as deficits in decision-making, planning or problem solving, which might interfere with weight loss in obese individuals. We performed a systematic review and meta-analysis of decision-making abilities, as measured with the Iowa gambling task (IGT), in obesity without eating disorders. METHODS: A systematic search was conducted to identify studies comparing IGT performances between groups of obese patients without eating disorders and groups of healthy control groups...
April 21, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28421080/b-cell-functions-can-be-modulated-by-antimicrobial-peptides-in-rainbow-trout-oncorhynchus-mykiss-novel-insights-into-the-innate-nature-of-b-cells-in-fish
#18
Xu-Jie Zhang, Peng Wang, Nu Zhang, Dan-Dan Chen, Pin Nie, Jia-Le Li, Yong-An Zhang
B cells in fish were recently proven to have potent innate immune activities like macrophages. This inspired us to further explore the innate nature of B cells in fish. Moreover, antimicrobial peptides (AMPs) are representative molecules of innate immunity, and they can modulate the functions of macrophages. These make fish an appropriate model to study the interactions between B cells and AMPs. Interestingly, the results in this study revealed that the IgM(+) and IgT(+) B cells of rainbow trout could express multiple AMP genes, including four cathelicidin genes and one β-defensin gene...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28416367/serum-galanin-concentration-is-increased-in-subjects-with-impaired-glucose-tolerance
#19
Zhenwen Zhang, Penghua Fang, Mei Yu, Yan Wang, Yin Li, Mingyi Shi, Ping Bo, Xuewen Gu, Yan Zhu
OBJECTIVES: Although extensive data have shown that galanin can regulate the food intake and glucose metabolism of animals, little is known regarding the galanin concentration in patients with impaired glucose tolerance (IGT). Therefore, the aims of this study were to investigate whether serum galanin levels and other metabolic parameters are changed in patients with IGT compared with controls with normal glucose tolerance (NGT). METHODS: Data regarding serum galanin levels and relative metabolic parameters were collected in 12 patients with IGT and 12 healthy patients with NGT...
April 14, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28403944/shape-of-the-ogtt-glucose-curve-and-risk-of-impaired-glucose-metabolism-in-the-egir-risc-cohort
#20
Melania Manco, Giuseppe Nolfe, Zoltan Pataky, Lucilla Monti, Francesca Porcellati, Rafael Gabriel, Asimina Mitrakou, Geltrude Mingrone
OBJECTIVE: To study whether the shape of the oral glucose tolerance test (OGTT)-glucose curve is a stable trait over time; it is associated with differences in insulin sensitivity, ß-cell function and risk of impaired fasting glucose (IFG) and glucose tolerance (IGT) in the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) cohort. METHODS: OGTT-glucose curve shape was classified as monophasic, biphasic, triphasic and anomalous in 915 individuals...
May 2017: Metabolism: Clinical and Experimental
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