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https://www.readbyqxmd.com/read/28726334/insulin-sensitivity-across-the-lifespan-from-obese-adolescents-to-obese-adults-with-impaired-glucose-tolerance-who-is-worse-off
#1
Silva Arslanian, Joon Young Kim, Alexis Nasr, Fida Bacha, Hala Tfayli, SoJung Lee, Frederico G S Toledo
OBJECTIVE: Youth type 2 diabetes mellitus (T2DM) occurs decades earlier than adult T2DM and is characterized by high therapeutic failure rates and decreased response to insulin sensitizers suggesting a more severe disease process than in adults. To explain these observations, we hypothesized that insulin resistance is worse in obese youth than adults with impaired glucose tolerance (IGT), a state of high-risk for T2DM. As proof-of-concept, we compared insulin sensitivity between BMI-, sex-, and race-matched obese youth vs adults with IGT...
July 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28725204/history-of-childhood-maltreatment-and-college-academic-outcomes-indirect-effects-of-hot-execution-function
#2
Marilyn C Welsh, Eric Peterson, Molly M Jameson
College students who report a history of childhood maltreatment may be at risk for poor outcomes. In the current study, we conducted an exploratory analysis to examine potential models that statistically mediate associations between aspects of maltreatment and aspects of academic outcome, with a particular focus on executive functions (EF). Consistent with contemporary EF research, we distinguished between relatively "cool" EF tasks (i.e., performed in a context relatively free of emotional or motivational valence) and "hot" EF tasks that emphasize performance under more emotionally arousing conditions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28720876/not-performing-an-ogtt-results-in-significant-underdiagnosis-of-pre-diabetes-in-a-high-risk-adult-caucasian-population
#3
A S Meijnikman, C E M De Block, E Dirinck, A Verrijken, I Mertens, B Corthouts, L F Van Gaal
OBJECTIVE: Type 2 diabetes (T2DM) is known to be underdiagnosed. Tests for diagnosis include fasting plasma glucose (FPG), oral glucose tolerance test (OGTT) and HbA1c. HbA1c can be tested in non-fasting conditions. Therefore, general practitioners almost no longer execute OGTT's. We evaluated the performance of OGTT versus HbA1c in a population consisting of overweight and obese subjects, which can be considered a 'high risk' population. RESEARCH DESIGN AND METHODS: 1241 overweight and obese subjects without a history of diabetes (Male/Female: 375/866, age 44±13 y, Body Mass Index 38...
July 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28713570/reduced-first-phase-insulin-secretion-increases-postprandial-lipidemia-in-subjects-with-impaired-glucose-tolerance
#4
Miguel Ángel Gómez-Sámano, Daniel Cuevas-Ramos, Mariana Grajales-Gómez, Marco Escamilla-Márquez, Angelina López-Estrada, Luz Elizabeth Guillén-Pineda, Guadalupe López-Carrasco, Francisco J Gómez-Pérez
OBJECTIVE: It is not clear which phase of insulin secretion is more important to regulate lipoprotein lipase (LPL) activity. After a meal, insulin is released and acts as a major regulator of LPL activity. Postprandial hyperlipidemia is a common comorbidity in subjects with insulin resistance (IR). Therefore this study aimed to evaluate the role of the first-phase insulin secretion (FPIS) on postprandial lipidemia in subjects with IR and impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS: This is a cross-sectional, observational and comparative study...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28712946/dissociation-between-decision-making-under-risk-and-decision-making-under-ambiguity-in-premanifest-and-manifest-huntington-s-disease
#5
Najia Adjeroud, Jeremy Besnard, Christophe Verny, Adriana Prundean, Clarisse Scherer, Bénédicte Gohier, Dominique Bonneau, Nicole El Massioui, Philippe Allain
We investigated decision-making under ambiguity (DM-UA) and decision making under risk (DM-UR) in individuals with premanifest and manifest Huntington's disease (HD). Twenty individuals with premanifest HD and 23 individuals with manifest HD, on one hand, and 39 healthy individuals divided into two control groups, on the other, undertook a modified version of the Iowa Gambling Task (IGT), an adaptation of a DM-UA task, and a modified version of the Game of Dice Task (GDT), an adaptation of a DM-UR task. Participants also filled in a questionnaire of impulsivity and responded to cognitive tests specifically designed to assess executive functions...
July 13, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28711517/prevention-of-type-2-diabetes-mellitus-in-polycystic-ovary-syndrome-a-review
#6
REVIEW
Safa Anwar, Nigar Shikalgar
Polycystic ovary syndrome (PCOS) is recognized as one of the most common endocrinopathies in women of reproductive age, associated with metabolic sequelae which includes increased risk factors for impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). The adverse effects of DM2 affects a woman throughout her lifespan. Health care expenditure of DM2 highlights the need for prevention through appropriate screening, diagnosis and intervention. Lifestyle modification (LSM) programs that include diet and/or physical activity are suggested for patients characterized as prediabetic to delay the onset of adult DM2...
July 8, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28697041/circulating-osteoprotegerin-in-postmenopausal-osteoporotic-women-marker-of-impaired-glucose-regulation-or-impaired-bone-metabolism
#7
Margarita Mashavi, Miriam Menaged, Marina Shargorodsky
OBJECTIVE: Osteoprotegerin (OPG) is closely related to insulin resistance and bone remodeling. However, no studies have examined the role of OPG in postmenopausal women with coexistent impaired glucose and bone regulation. The present study investigated the relationship of OPG to glucose homeostasis and insulin resistance in postmenopausal osteoporotic women with different types of glucose tolerance. METHODS: In all, 114 postmenopausal osteoporotic women were divided into three groups according to glucose tolerance status: 51 with normal glucose tolerance (NGT, group 1), 31 with impaired glucose tolerance (IGT, group 2), and 32 with type 2 diabetes mellitus (DM, group 3)...
July 10, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28685718/clinical-characteristics-electrophysiology-and-skin-biopsy-of-38-peripheral-neuropathy-cases-with-small-fiber-involvement-of-various-etiologies
#8
Bo Sun, Li-Zhi Liu, Yi-Fan Li, Zhao-Hui Chen, Li Ling, Fei Yang, Fang Cui, Xu-Sheng Huang
BACKGROUND: In small fiber neuropathy (SFN), thinly myelinated Aδ and unmyelinated C fibers are primarily affected, resulting in sensory and/or autonomic symptoms. Various etiologies have been shown to be associated with SFN. This study was aimed to analyze a variety of features in peripheral neuropathy (PN) with small fiber involvement, and to compare disease severity among patients with idiopathic PN, PN associated with impaired glucose tolerance (IGT), and metabolic syndrome (MS) PN...
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28685273/bayesian-techniques-for-analyzing-group-differences-in-the-iowa-gambling-task-a-case-study-of-intuitive-and-deliberate-decision-makers
#9
REVIEW
Helen Steingroever, Thorsten Pachur, Martin Šmíra, Michael D Lee
The Iowa Gambling Task (IGT) is one of the most popular experimental paradigms for comparing complex decision-making across groups. Most commonly, IGT behavior is analyzed using frequentist tests to compare performance across groups, and to compare inferred parameters of cognitive models developed for the IGT. Here, we present a Bayesian alternative based on Bayesian repeated-measures ANOVA for comparing performance, and a suite of three complementary model-based methods for assessing the cognitive processes underlying IGT performance...
July 6, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28683803/westernization-of-lifestyle-affects-quantitative-and-qualitative-changes-in-adiponectin
#10
Mitsunobu Kubota, Masayasu Yoneda, Norikazu Maeda, Haruya Ohno, Kenji Oki, Tohru Funahashi, Iichiro Shimomura, Noboru Hattori
BACKGROUND: Although Japanese-Americans and native Japanese share the same genetic predispositions, they live different lifestyles, resulting in insulin resistance in Japanese-Americans. We investigated whether the quantitative and qualitative changes in adiponectin (APN) due to differences in lifestyle contribute to the development of insulin resistance. METHODS: We evaluated 325 native Japanese in Hiroshima, Japan and 304 Japanese-Americans in Los Angeles, the United States, who were aged between 30 and 70 years and underwent medical examinations between 2009 and 2010...
July 6, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28683308/microbial-host-co-metabolites-are-prodromal-markers-predicting-phenotypic-heterogeneity-in-behavior-obesity-and-impaired-glucose-tolerance
#11
Marc-Emmanuel Dumas, Alice R Rothwell, Lesley Hoyles, Thomas Aranias, Julien Chilloux, Sophie Calderari, Elisa M Noll, Noémie Péan, Claire L Boulangé, Christine Blancher, Richard H Barton, Quan Gu, Jane F Fearnside, Chloé Deshayes, Christophe Hue, James Scott, Jeremy K Nicholson, Dominique Gauguier
The influence of the gut microbiome on metabolic and behavioral traits is widely accepted, though the microbiome-derived metabolites involved remain unclear. We carried out untargeted urine (1)H-NMR spectroscopy-based metabolic phenotyping in an isogenic C57BL/6J mouse population (n = 50) and show that microbial-host co-metabolites are prodromal (i.e., early) markers predicting future divergence in metabolic (obesity and glucose homeostasis) and behavioral (anxiety and activity) outcomes with 94%-100% accuracy...
July 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/28676377/is-there-a-connection-between-postprandial-hyperglycemia-and-igt-related-sensory-nerve-dysfunction
#12
N Németh, Z Putz, I Istenes, A E Körei, O E Vági, M Kempler, R Gandhi, G Jermendy, S Tesfaye, Á G Tabák, P Kempler
BACKGROUND AND AIMS: To assess the risk factors for sensory nerve dysfunction in subjects with isolated impaired glucose tolerance (IGT). METHODS AND RESULTS: Seventy-two people with isolated IGT (WHO 1999 criteria) and 39 gender and age-matched healthy volunteers underwent detailed clinical and neurological assessment including quantitative sensory testing using the Neurometer device (current perception threshold measurement on four limbs at three different frequencies)...
May 11, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28662009/-the-assessment-of-risk-factors-for-glucose-metabolism-disorders
#13
Katarzyna Jończyk-Skórka, Jan Kowalski
AIM: The aim of the study was to assess risk factors for glucose metabolism disorders. MATERIALS AND METHODS: The study involved 197 people, 92 women and 105 men aged 63.21±8.74 years. In order to assess glucose metabolism disorders, patients were divided into three groups. The first group (DM) consisted of 60 people (16 women and 44 men aged 61.92±8.46 years). These were people with type 2 diabetes. Second group (IFG IGT) consisted of 67 people (35 women and 32 men aged 65±8...
June 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28659867/increased-short-term-beat-to-beat-qt-interval-variability-in-patients-with-impaired-glucose-tolerance
#14
Andrea Orosz, István Baczkó, Szabolcs Nyiraty, Anna E Körei, Zsuzsanna Putz, Róbert Takács, Attila Nemes, Tamás T Várkonyi, László Balogh, György Ábrahám, Péter Kempler, Julius Gy Papp, András Varró, Csaba Lengyel
Prediabetic states and diabetes are important risk factors for cardiovascular morbidity and mortality. Determination of short-term QT interval variability (STVQT) is a non-invasive method for assessment of proarrhythmic risk. The aim of the study was to evaluate the STVQT in patients with impaired glucose tolerance (IGT). 18 IGT patients [age: 63 ± 11 years, body mass index (BMI): 31 ± 6 kg/m(2), fasting glucose: 6.0 ± 0.4 mmol/l, 120 min postload glucose: 9.0 ± 1.0 mmol/l, hemoglobin A1c (HbA1c): 5...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28659162/acupuncture-paired-with-herbal-medicine-for-prediabetes-study-protocol-for-a-randomized-controlled-trial
#15
Xinger Li, Haiyan Liu, Huiping Feng, Zhongren Xian, Yanhong Chen, Jianping Chen, Chunzhi Tang, Xinsheng Lai, Xiaoling Lan, Huanzhen Huang, Dongdong Yu
BACKGROUND: Type-2 diabetes has become a major disease and is known to seriously impair people's health worldwide. Prediabetes includes impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and is the most critical period for preventing type-2 diabetes, as it can be identified and reversed. Studies in the past decade have indicated that acupuncture and Chinese herbal medicine may be beneficial for treating prediabetes. However, a randomized controlled trial (RCT) should be conducted to obtain more clinical evidence on this topic...
June 28, 2017: Trials
https://www.readbyqxmd.com/read/28658166/a-cross-sectional-study-on-the-associations-of-insulin-resistance-with-sex-hormone-abnormal-lipid-metabolism-in-t2dm-and-igt-patients
#16
Xiaoxia Wang, Tongzhang Xian, Xiaofan Jia, Lina Zhang, Li Liu, Fuli Man, Xianbo Zhang, Jie Zhang, Qi Pan, Lixin Guo
Type 2 diabetes mellitus (T2DM) is a long-term metabolic disorder. It is characterized by hyperglycemia, insulin resistance (IR), and relative impairment in insulin secretion. IR plays a major role in the pathogenesis of T2DM. Many previous studies have investigated the relationship between estrogen, androgen, and obesity, but few focused on the relationship between sex hormones, abnormal lipid metabolism, and IR. The goal for the present study was to identify the association of IR with sex hormone, abnormal lipid metabolism in type 2 diabetes, and impaired glucose tolerance (IGT) patients...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28611053/the-rs7903146-variant-in-the-tcf7l2-gene-increases-the-risk-of-prediabetes-type-2-diabetes-in-obese-adolescents-by-impairing-%C3%AE-cell-function-and-hepatic-insulin-sensitivity
#17
Catrina Cropano, Nicola Santoro, Leif Groop, Chiara Dalla Mann, Claudio Cobelli, Alfonso Galderisi, Romy Kursawe, Bridget Pierpont, Martina Goffredo, Sonia Caprio
OBJECTIVE: In this study, we aimed to explore the mechanism by which TCF7L2 rs7903146 risk allele confers susceptibility to impaired glucose tolerance (IGT) or type 2 diabetes (T2D) in obese adolescents. RESEARCH DESIGN AND METHODS: The rs7903146 variant in the TCF7L2 gene was genotyped in a multiethnic cohort of 955 youths. All subjects underwent an oral glucose tolerance test with the use of the Oral Minimal Model to assess insulin secretion, and 33 subjects underwent a hyperinsulinemic-euglycemic clamp...
June 13, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28596534/circulating-3-carboxy-4-methyl-5-propyl-2-furanpropanoic-acid-cmpf-levels-are-associated-with-hyperglycemia-and-%C3%AE-cell-dysfunction-in-a-chinese-population
#18
Shan Zhang, Peihong Chen, Hua Jin, Jufen Yi, Xinmiao Xie, Meili Yang, Ting Gao, Lili Yang, Cheng Hu, Xueli Zhang, Xuemei Yu
Several recent clinical studies have suggested that the levels of circulating 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) are significantly higher in patients with gestational diabetes mellitus (GDM), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM). This study recruited a total of 516 participants. The following patient populations were enrolled: 99 newly diagnosed cases with T2DM, 219 cases with prediabetes [82 with isolated impaired glucose tolerance (I - IGT), 66 with isolated impaired fasting glucose (I - IFG) and 71 with impaired glucose tolerance and impaired fasting glucose (IGT + IFG)], and 198 cases with normal glucose tolerance [NGT, including 99 first-degree relatives of type 2 diabetes patients (FDRs) and 99 non-FDRs]...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28595173/effects-of-weight-loss-with-and-without-exercise-on-regional-body-fat-distribution-in-postmenopausal-women
#19
Monica C Serra, Jacob B Blumenthal, Odessa R Addison, Ann J Miller, Andrew P Goldberg, Alice S Ryan
BACKGROUND/AIMS: The purpose was to determine whether lifestyle interventions have different effects on regional fat in women with normal glucose tolerance vs. impaired glucose tolerance (NGT vs. IGT). METHODS: Changes in glucose metabolism (2-h oral glucose-tolerance tests), android to gynoid fat mass ratio (dual energy X-ray absorptiometry [DXA]), visceral to subcutaneous abdominal fat area ratio (CT), and abdominal to gluteal subcutaneous fat cell weight (FCW; adipose tissue biopsies) were determined in 60 overweight postmenopausal women (45-80 years) following 6 months of weight loss alone (WL; n = 28) or with aerobic exercise (AEX + WL; n = 32)...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28591087/hyperhomocysteinemia-as-a-metabolic-risk-factor-for-glucose-intolerance-among-high-risk-groups-of-chinese-adults
#20
Xiaomeng Feng, Yuan Xu
BACKGROUND Impaired glucose tolerance (IGT) is characterized by insulin resistance and causes atherosclerosis. Hyperhomocysteinemia is associated with insulin resistance and predicts cardiovascular diseases. In this study, we assessed the possible association between homocysteine and IGT. MATERIAL AND METHODS This was a cross-sectional study of 118 consecutive subjects with IGT (IGT group) and 128 consecutive subjects with normal glucose tolerance (NGT group). Homocysteine and clinical characteristics were measured...
June 7, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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