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https://www.readbyqxmd.com/read/29778250/surgical-management-of-intraductal-papillary-mucinous-neoplasm-with-main-duct-involvement-an-international-expert-survey-and-case-vignette-study
#1
Lianne Scholten, Nadine C M van Huijgevoort, Marco J Bruno, Carlos Fernandez-Del Castillo, Sohei Satoi, Alain Sauvanet, Christopher Wolfgang, Paul Fockens, Suresh T Chari, Marco Del Chiaro, Jeanin E van Hooft, Marc G Besselink
BACKGROUND: The risk of invasive cancer in resected intraductal papillary mucinous neoplasm with main pancreatic duct involvement is 33%-60%. Most guidelines, therefore, advise resection of main duct intraductal papillary mucinous neoplasm and mixed type intraductal papillary mucinous neoplasm in surgically fit patients, although advice on the surgical strategy (partial or total pancreatectomy) differs. We performed a survey amongst international experts to guide the design of future studies and help to prepare for a single international set of guidelines...
May 16, 2018: Surgery
https://www.readbyqxmd.com/read/29773761/surgical-treatment-of-pancreatic-cancer
#2
Wioletta Masiak-Segit, Karol Rawicz-Pruszyński, Magdalena Skórzewska, Wojciech P Polkowski
The only way to cure the patient with adenocarcinoma of the pancreas (RT) is surgical excision of the tumor. The standard surgical treatment of resectable pancreatic carcinoma is considered the classic pancreatoduodenectomy (PD) with the Kausch- Whipple procedure, or the pylorus-preserving PD with the Traverso-Longmire method. The most difficult technically and at the same time the most important PD stage from an oncological point of view is the separation of the head of the pancreas from the superior mesenteric artery...
April 30, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29770302/percutaneous-microwave-thermosphere-ablation-of-pancreatic-tumours
#3
Anna Maria Ierardi, Pierpaolo Biondetti, Andrea Coppola, Enrico Maria Fumarola, Alberto Magenta Biasina, Salvatore Alessio Angileri, Gianpaolo Carrafiello
Background: In oncologic field, thermo-ablative procedures have spread more and more. Percutaneous microwave ablation (MWA) showed same benefits and some advantages over radiofrequency ablation (RFA). To date, a disadvantage of both was the not totally predictable size and shape of ablation volume. The aim of this study was to assess feasibility and safety of MWA in nonresectable pancreatic head cancer using a new technology of MW with high power (100 W) and frequency of 2,450 MH. Methods: Five patients with pancreatic head cancer treated with percutaneous MWA under ultrasound guidance were retrospectively reviewed...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29769629/risk-of-multiple-pancreatic-cancers-in-cdkn2a-p16-leiden-mutation-carriers
#4
Isaura Ibrahim, Babs G Sibinga Mulder, Bert Bonsing, Hans Morreau, Arantza Farina Sarasqueta, Akin Inderson, Saskia Luelmo, Shirin Feshtali, Thomas P Potjer, Wouter de Vos Tot Nederveen Cappel, Martin Wasser, Hans F A Vasen
CDKN2A-p16-Leiden mutation carriers have a substantial risk of developing pancreatic ductal adenocarcinoma (PDAC). One of the main clinical features of hereditary cancer is the development of multiple cancers. Since 2000, we have run a surveillance program for CDKN2A-p16-Leiden mutation carriers. The patients are offered a yearly MRI with optionally endoscopic ultrasound. In patients with a confirmed lesion, usually, a partial resection of the pancreas is recommended. A total of 18 PDAC (8.3%) were detected in 218 mutation carriers...
May 16, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29752276/classification-of-pancreatic-cancer-ready-for-practical-application
#5
Danny N Khalil, Eileen M O'Reilly
There is great interest in an ability to categorize pancreas cancer and understand and classify the significant heterogeneity that exists in this disease. Such classifications based on morphologic, genetic, and immunologic features are emerging and the application of this information to provide both prognostic and predictive information is highly desired.
May 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29750397/fdg-pet-ct-in-the-evaluation-of-primary-and-secondary-pancreatic-malignancies
#6
Casey E Bohl, Sara M Federico, Giles W Robinson, Armita Bahrami, Barry L Shulkin
PURPOSE: Primary pancreatic carcinoma and pancreatic metastases are rare in the pediatric population. Pancreatoblastoma is the most common pancreatic malignant tumor in young children and solid-pseudopapillary tumor in teenagers. Pancreatic adenocarcinoma is extremely rare under the age of 40 and is usually associated with underlying genetic abnormalities. Secondary malignancies of the pancreas occur more frequently than primary pancreatic malignancies in children and are most commonly seen with non-Hodgkin lymphomas (NHL) and mesenchymal sarcomas...
May 11, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29748382/satellite-rna-increases-dna-damage-and-accelerates-tumor-formation-in-mouse-models-of-pancreatic-cancer
#7
Takahiro Kishikawa, Motoyuki Otsuka, Tatsunori Suzuki, Takahiro Seimiya, Kazuma Sekiba, Rei Ishibashi, Eri Tanaka, Motoko Ohno, Mari Yamagami, Kazuhiko Koike
Highly repetitive tandem arrays such as satellite sequences in the centromeric and pericentromeric regions of chromosomes, which were previously considered to be silent, are actively transcribed in various biological processes, including cancers. In the pancreas, this aberrant expression occurs even in Kras-mutated pancreatic intraepithelial neoplasia (PanIN) tissues, which are precancerous lesions. To determine the biological role of satellite RNAs in carcinogenesis in vivo, we constructed mouse major satellite (MajSAT) RNA-expressing transgenic mice...
May 10, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29745561/-image-segmentation-and-classification-of-cytological-cells-based-on-multi-features-clustering-and-chain-splitting-model
#8
Pin Wang, Qianqian Liu, Lirui Wang, Yongming Li, Shujun Liu, Fang Yan
The diagnosis of pancreatic cancer is very important. The main method of diagnosis is based on pathological analysis of microscopic image of Pap smear slide. The accurate segmentation and classification of images are two important phases of the analysis. In this paper, we proposed a new automatic segmentation and classification method for microscopic images of pancreas. For the segmentation phase, firstly multi-features Mean-shift clustering algorithm (MFMS) was applied to localize regions of nuclei. Then, chain splitting model (CSM) containing flexible mathematical morphology and curvature scale space corner detection method was applied to split overlapped cells for better accuracy and robustness...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29736383/analysis-of-kras-gene-from-induced-pancreatic-cancer-rats-administered-with-momordica-charantia-and-ocimum-ba-s-ilicum-leaf-extracts
#9
J B Minari, C A Okelola, N C Ugochukwu
Objective: To analyze K-ras gene from induced pancreatic cancer rats administered with Momordica charantia and Ocimum basilicum leaf extracts. Methods: Twenty-five (25) adult rats weighing between 90-120 g were divided into 5 groups namely RA, RB, RC, NC and PC, each group had 5 rats. The PC which served as the control was fed with normal fish meal and water ad libitum; the NC which is the negative control received 20 mg/ml/week of Nitrosamines only while other groups received different concentrations of aqueous extract of both M ...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29733315/an-in-vivo-murine-sciatic-nerve-model-of-perineural-invasion
#10
Sylvie Deborde, Yasong Yu, Andrea Marcadis, Chun-Hao Chen, Ning Fan, Richard L Bakst, Richard J Wong
Cancer cells invade nerves through a process termed perineural invasion (PNI), in which cancer cells proliferate and migrate in the nerve microenvironment. This type of invasion is exhibited by a variety of cancer types, and very frequently is found in pancreatic cancer. The microscopic size of nerve fibers within mouse pancreas renders the study of PNI difficult in orthotopic murine models. Here, we describe a heterotopic in vivo model of PNI, where we inject syngeneic pancreatic cancer cell line Panc02-H7 into the murine sciatic nerve...
April 23, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29732356/clinical-significance-of-pancreatic-intraepithelial-neoplasia-in-resectable-pancreatic-cancer-on-survivals
#11
Da-Young Yu, Young-Dong Yu, Wan-Bae Kim, Hyung-Joon Han, Sae-Byul Choi, Dong-Sik Kim, Sang-Yong Choi, Joo-Young Kim, Hyeyoon Chang, Baek-Hui Kim
Purpose: Noninvasive precursor lesions for pancreatic adenocarcinoma include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. PanIN is often found synchronously adjacent to resected pancreatic ductal adenocarcinoma (PDAC) tumors. However, its prognostic significance on outcome after PDAC resection is unknown. The purpose of the current study was to determine if the presence of PanIN has a prognostic or predictive effect on survival after resection for PDAC with curative intent...
May 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29721179/glypican-1-is-enriched-in-circulating-exosomes-in-pancreatic-cancer-and-correlates-with-tumor-burden
#12
Adam E Frampton, Mireia Mato Prado, Elena López-Jiménez, Ana Belen Fajardo-Puerta, Zaynab A R Jawad, Phillip Lawton, Elisa Giovannetti, Nagy A Habib, Leandro Castellano, Justin Stebbing, Jonathan Krell, Long R Jiao
Background: Glypican-1 (GPC1) is expressed in pancreatic ductal adenocarcinoma (PDAC) cells and adjacent stromal fibroblasts. Recently, GPC1 circulating exosomes (crExos) have been shown to be able to detect early stages of PDAC. In this study, we investigated the usefulness of crExos GPC1 as a biomarker for PDAC. Methods: Plasma was obtained from patients with benign pancreatic disease ( n = 16) and PDAC ( n = 27) prior to pancreatectomy, and crExos were isolated by ultra-centrifugation...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29719936/induced-ptf1a-expression-in-pancreatic-ductal-adenocarcinoma-cellsactivates-acinar-gene-networks-reduces-tumorigenic-properties-and-sensitizes-cells-to-gemcitabine-treatment
#13
Brad L Jakubison, Patrick G Schweickert, Sarah E Moser, Yi Yang, Hongyu Gao, Kathleen Scully, Pamela Itkin-Ansari, Yunlong Liu, Stephen F Konieczny
Pancreatic acinar cells synthesize, package, and secrete digestive enzymes into the duodenum to aid in nutrient absorption and meet metabolic demands. When exposed to cellular stresses and insults acinar cells undergo a dedifferentiation process termed acinar-ductal metaplasia (ADM). ADM lesions with oncogenic mutations eventually give rise to pancreatic ductal adenocarcinoma (PDAC). In healthy pancreata, the basic helix-loop-helix (bHLH) factors MIST1 and PTF1a coordinate an acinar-specific transcription network that maintains the highly developed differentiation status of the cells, protecting the pancreas from undergoing a transformative process...
May 2, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29709558/bursectomy-versus-omentectomy-alone-for-resectable-gastric-cancer-jcog1001-a-phase-3-open-label-randomised-controlled-trial
#14
Yukinori Kurokawa, Yuichiro Doki, Junki Mizusawa, Masanori Terashima, Hitoshi Katai, Takaki Yoshikawa, Yutaka Kimura, Shuji Takiguchi, Yasunori Nishida, Norimasa Fukushima, Yoshiaki Iwasaki, Masahide Kaji, Motohiro Hirao, Hiroshi Katayama, Mitsuru Sasako
BACKGROUND: The role of bursectomy, in which the peritoneal lining covering the pancreas and the anterior plane of the transverse mesocolon are dissected, has long been controversial for preventing peritoneal metastasis. We investigated the survival benefit of bursectomy in patients with resectable gastric cancer. METHODS: This phase 3, open-label, randomised controlled trial was done at 57 hospitals in Japan. Patients aged 20-80 years who had cT3(SS)-cT4a(SE) histologically proven gastric adenocarcinoma with an Eastern Cooperative Oncology Group performance status of 0 or 1 and body-mass index less than 30 kg/m2 and who did not have distant metastasis or bulky lymph nodes were randomly assigned (1:1) during surgery to receive omentectomy alone (non-bursectomy) or bursectomy...
April 27, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29705685/translational-genomics-in-pancreatic-ductal-adenocarcinoma-a-review-with-re-analysis-of-tcga-dataset
#15
REVIEW
Jeffery Ho, Xianchun Li, Lin Zhang, Yonghao Liang, Wei Hu, Johnny C W Yau, Hung Chan, Tony Gin, Matthew T V Chan, Gary Tse, William K K Wu
Malignancy of the pancreas is a leading cause of cancer-related mortality, with the highest case-fatality of all cancers. Nevertheless, the lack of sensitive biomarkers and presence of biological heterogeneity precludes its early detection and effective treatment. The recent introduction of next-generation sequencing allows characterization of multiple driver mutations at genome- and exome-wide levels. Sequencing of DNA and RNA from circulating tumour cells has also opened an exciting era of non-invasive procedures for tumour detection and prognostication...
April 25, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29705629/method-optimization-for-extracting-high-quality-rna-from-the-human-pancreas-tissue
#16
Eunsung Jun, Juyun Oh, Song Lee, Hye-Ryeong Jun, Eun Hye Seo, Jin-Young Jang, Song Cheol Kim
Nucleic acid sequencing is frequently used to determine the molecular basis of diseases. Therefore, proper storage of biological specimens is essential to inhibit nucleic acid degradation. RNA isolated from the human pancreas is generally of poor quality because of its high concentration of endogenous RNase. In this study, we optimized the method for extracting high quality RNA from paired tumor and normal pancreatic tissues obtained from eight pancreatic cancer patients post-surgery. RNA integrity number (RIN) was checked to evaluate the integrity of RNA, we tried to extract the RNA with an RIN value of 8 or higher that allows for the latest genetic analysis...
April 26, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29703704/dosimetric-analysis-of-stereotactic-body-radiation-therapy-for-pancreatic-cancer-using-mr-guided-tri-60-co-unit-mr-guided-linac-and-conventional-linac-based-plans
#17
Stephen James Ramey, Kyle R Padgett, Narottam Lamichhane, Hanmath J Neboori, Deukwoo Kwon, Eric A Mellon, Karen Brown, Melissa Duffy, James Victoria, Nesrin Dogan, Lorraine Portelance
PURPOSE: This study aims to perform a dosimetric comparison of 2 magnetic resonance (MR)-guided radiation therapy systems capable of performing online adaptive radiation therapy versus a conventional radiation therapy system for pancreas stereotactic body radiation therapy. METHODS AND MATERIALS: Ten cases of patients with pancreatic adenocarcinoma previously treated in our institution were used for this analysis. MR-guided tri-cobalt 60 therapy (MR-cobalt) and MR-LINAC plans were generated and compared with conventional LINAC (volumetric modulated arc therapy) plans...
March 1, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29702531/intraductal-papillary-mucinous-neoplasm-of-the-pancreas-as-the-main-focus-for-early-detection-of-pancreatic-adenocarcinoma
#18
Masao Tanaka
For early detection of pancreatic cancer, interests are now focused on the detection of high-risk individuals to undergo screening examinations. Intraductal papillary mucinous neoplasm (IPMN) is a unique dual precursor of pancreatic cancer, characterized by progression to invasive cancer and the development of pancreatic adenocarcinoma either concomitantly (synchronous occurrence) or even after resection of IPMN (metachronous occurrence). Careful examination and surveillance of patients with IPMN may therefore lead to early detection of pancreatic cancer...
May 2018: Pancreas
https://www.readbyqxmd.com/read/29700299/epigenetic-reprogramming-using-5-azacytidine-promotes-an-anti-cancer-response-in-pancreatic-adenocarcinoma-cells
#19
Luc Gailhouste, Lee Chuen Liew, Izuho Hatada, Hitoshi Nakagama, Takahiro Ochiya
Curative management of pancreatic adenocarcinoma is limited because this malignancy remains resistant to most chemotherapeutic drugs. Strategies that reverse epigenetic alterations offer a unique opportunity for cancer cell reprogramming, which is valuable for development of new treatments. The aim of this work was to reprogram pancreatic ductal adenocarcinoma (PDAC) cells toward a less aggressive and drug-responsive phenotype. The process applied is called "epigenetic reprogramming". To evaluate the efficiency of PDAC epigenetic reprogramming, we assessed tumor growth and drug response in PANC-1 cells after exposure to non-cytotoxic doses of the demethylating agent 5-azacytidine (5-AZA)...
April 27, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29693047/pancreatic-hif2%C3%AE-stabilization-leads-to-chronic-pancreatitis-and-predisposes-to-mucinous-cystic-neoplasm
#20
Heather K Schofield, Manuj Tandon, Min-Jung Park, Christopher J Halbrook, Sadeesh K Ramakrishnan, Esther C Kim, Jiaqi Shi, M Bishr Omary, Yatrik M Shah, Farzad Esni, Marina Pasca di Magliano
Background & Aims: Tissue hypoxia controls cell differentiation in the embryonic pancreas, and promotes tumor growth in pancreatic cancer. The cellular response to hypoxia is controlled by the hypoxia-inducible factor (HIF) proteins, including HIF2α. Previous studies of HIF action in the pancreas have relied on loss-of-function mouse models, and the effects of HIF2α expression in the pancreas have remained undefined. Methods: We developed several transgenic mouse models based on the expression of an oxygen-stable form of HIF2α, or indirect stabilization of HIF proteins though deletion of von Hippel-Lindau, thus preventing HIF degradation...
2018: Cellular and Molecular Gastroenterology and Hepatology
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