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Vaginal yeast

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https://www.readbyqxmd.com/read/28642006/exoenzyme-activity-and-possibility-identification-of-candida-dubliniensis-among-candida-albicans-species-isolated-from-vaginal-candidiasis
#1
Maryam Jafari, Samira Salari, Keyvan Pakshir, Kamiar Zomorodian
OBJECTIVES: Vulvovaginal candidiasis (VVC) or vaginal candidiasis is a common fungal infection of the genitals causing inflammation, irritation, itching, and vaginal discharge. Common yeast infections are caused by the yeast species C. albicans. However, there are other species of Candida such as C. dubliniensis which are considered as the causative agents of this infection. Hydrolytic enzymes such as proteinase and coagulase are known as virulence factors. The aim of this study was the molecular confirmation and differentiation of C...
June 19, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28531212/epidemiological-investigation-of-the-relationship-between-common-lower-genital-tract-infections-and-high-risk-human-papillomavirus-infections-among-women-in-beijing-china
#2
Dai Zhang, Ting Li, Lei Chen, Xiaosong Zhang, Gengli Zhao, Zhaohui Liu
BACKGROUND: The incidence of lower genital tract infections in China has been increasing in recent years. The link between high-risk human papillomavirus (HR-HPV) and other sexually transmitted diseases (STDs) remains unclear. METHODS: From March to October 2014, gynecological examinations and questionnaires were conducted on 1218 married women. Cervical secretions and vaginal swab specimens were tested for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Ureaplasma urealyticum (UU), yeast, clue cells and HR-HPV...
2017: PloS One
https://www.readbyqxmd.com/read/28515716/antifungal-activity-of-the-biphosphinic-cyclopalladate-c7a-against-candida-albicans-yeast-forms-in-vitro-and-in-vivo
#3
Julian E Muñoz, Diego C P Rossi, Kelly Ishida, Cristina C Spadari, Marcia S C Melhem, Daniel M Garcia, Antonio C F Caires, Carlos P Taborda, Elaine G Rodrigues
Vulvovaginal and invasive candidiasis are frequent conditions in immunosuppressed individuals caused by Candida albicans and non-albicans Candida spp. Fluconazole and Amphotericin B are the main drugs used to fight the infection. However, resistance to fluconazole and other azole antifungal drugs is an important clinical problem that encourages the search for new therapeutic alternatives. In this work, we evaluate the antifungal activity of the biphosphinic cyclopalladate C7a in the in vitro and in vivo model...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28491253/isolation-molecular-identification-and-antifungal-susceptibility-profiles-of-vaginal-isolates-of-candida-species
#4
Ali Rezaei-Matehkolaei, Shokoofe Shafiei, Ali Zarei-Mahmoudabadi
BACKGROUND AND OBJECTIVES: Vulvovaginal candidiasis is a common fungal infection among women during reproductive ages. Although, Candida albicans is accounted as the main etiologic agent of vaginitis, non-albicans species have arisen during last years. Resistant to antifungal drugs especially, fluconazole has been more reported by researchers from around the World. The aims of this study were to determine the prevalence of vulvovaginal candidiasis among suspected patients with vaginitis, the frequency of Candida species, and the susceptibility profiles of isolates to caspofungin, fluconazole and clotrimazole...
December 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28421058/antimicrobial-compounds-produced-by-vaginal-lactobacillus-crispatus-are-able-to-strongly-inhibit-candida-albicans-growth-hyphal-formation-and-regulate-virulence-related-gene-expressions
#5
Shuai Wang, Qiangyi Wang, Ence Yang, Ling Yan, Tong Li, Hui Zhuang
The female vaginal environment contains diverse microorganisms, and their interactions play significant roles in health and disease. Lactobacillus species are the predominant vaginal microorganisms in healthy women and relevant as a barrier to defense against pathogens, including Candida albicans. The yeast-to-hyphae transition is believed to be a determinant of C. albicans pathogenesis. In this study, we investigated the effects of vaginal isolates of L. crispatus (seven strains), L. gasseri (six strains), and L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28421052/whole-genome-based-amplified-fragment-length-polymorphism-analysis-reveals-genetic-diversity-in-candida-africana
#6
Anuradha Chowdhary, Ferry Hagen, Cheshta Sharma, Abdullah M S Al-Hatmi, Letterio Giuffrè, Domenico Giosa, Shangrong Fan, Hamid Badali, Maria Rosa Felice, Sybren de Hoog, Jacques F Meis, Orazio Romeo
This study aimed at investigating the genetic diversity of a panel of Candida africana strains recovered from vaginal samples in different countries. All fungal strains were heterozygous at the mating-type-like locus and belonged to the genotype A of Candida albicans. Moreover, all examined C. africana strains lack N-acetylglucosamine assimilation and sequence analysis of the HXK1 gene showed a distinctive polymorphism that impair the utilization of this amino sugar in this yeast. Multi-locus sequencing of seven housekeeping genes revealed a substantial genetic homogeneity among the strains, except for the CaMPIb, SYA1 and VPS13 loci which contributed significantly to the classification of our set of C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28391495/boric-acid-inhibition-of-trichophyton-rubrum-growth-and-conidia-formation
#7
Martin Schmidt
Trichophyton rubrum is a common human dermatophyte that is the causative agent of 80-93% of fungal infections of the skin and nails. While dermatophyte infections in healthy people are easily treatable with over-the-counter medications, such infections pose a higher risk for patients with compromised immune function and impaired regenerative potential. The efficacy of boric acid (BA) for the treatment of vaginal yeast infections prompted an investigation of the effect of BA on growth and morphology of T. rubrum...
April 8, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28385421/prevalence-of-candida-albicans-candida-dubliniensis-and-candida-africana-in-pregnant-women-suffering-from-vulvovaginal-candidiasis-in-argentina
#8
María Josefina Mucci, María Luján Cuestas, María Fernanda Landanburu, María Teresa Mujica
BACKGROUND: Vulvovaginal candidiasis (VVC) is a vulvovaginitis commonly diagnosed in gynecology care. In recent years, the taxonomy of the most important pathogenic Candida species, such as Candida albicans have undergone significant changes. AIMS: This study examined the prevalence of C. albicans, Candida africana, and Candida dubliniensis in vaginal specimens from 210 pregnant women suffering from vulvovaginitis or having asymptomatic colonization. METHODS: Phenotypic and molecular methods were used for the identification of the species...
April 3, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28369145/polyethylene-glycol-functionalized-poly-lactic-acid-co-glycolic-acid-and-graphene-oxide-nanoparticles-induce-pro-inflammatory-and-apoptotic-responses-in-candida-albicans-infected-vaginal-epithelial-cells
#9
R Doug Wagner, Shemedia J Johnson, Zhixia Yan Danielsen, Jin-Hee Lim, Thilak Mudalige, Sean Linder
Mucous-penetrating nanoparticles consisting of poly lactic acid-co-glycolic acid (PLGA)-polyethylene glycol (PEG) could improve targeting of microbicidal drugs for sexually transmitted diseases by intravaginal inoculation. Nanoparticles can induce inflammatory responses, which may exacerbate the inflammation that occurs in the vaginal tracts of women with yeast infections. This study evaluated the effects of these drug-delivery nanoparticles on VK2(E6/E7) vaginal epithelial cell proinflammatory responses to Candida albicans yeast infections...
2017: PloS One
https://www.readbyqxmd.com/read/28314677/vulvovaginal-candidiasis-etiology-symptomatology-and-risk-factors
#10
L Mtibaa, N Fakhfakh, A Kallel, S Belhadj, N Belhaj Salah, N Bada, K Kallel
OBJECTIVE: To determine epidemiological, clinical and mycological characteristics of vulvovaginal candidiasis (VVC) in Tunisian population and to evaluate predisposing factors. PATIENTS AND METHODS: In this retrospective study, 2160 vaginal swabs were performed over 2 years (January 2014-December 2015). It was carried out at the laboratory of Parasitology and Mycology, Rabta Hospital in Tunisia. After swab collecting, direct examination and culture on Sabouraud Chloramphenicol and Sabouraud Chloramphenicol Actidione media were implemented to research yeasts...
March 14, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28293217/mechanistic-insights-underlying-tolerance-to-acetic-acid-stress-in-vaginal-candida-glabrata-clinical-isolates
#11
Diana V Cunha, Sara B Salazar, Maria M Lopes, Nuno P Mira
During colonization of the vaginal tract Candida glabrata cells are challenged with the presence of acetic acid at a low pH, specially when dysbiosis occurs. To avoid exclusion from this niche C. glabrata cells are expected to evolve efficient adaptive responses to cope with this stress; however, these responses remain largely uncharacterized, especially in vaginal strains. In this work a cohort of 18 vaginal strains and 2 laboratory strains (CBS138 and KUE100) were phenotyped for their tolerance against inhibitory concentrations of acetic acid at pH 4...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28263903/candida-and-its-dual-lifestyle-as-a-commensal-and-a-pathogen
#12
Mathieu Cauchie, Stefanie Desmet, Katrien Lagrou
Candida spp. are part of the normal vaginal microflora in 20-30% of healthy women. However, if the balance between these yeasts and the host is disturbed, Candida spp. can cause vulvovaginal candidiasis (VVC), with Candida albicans being the major causative agent. Different studies have been performed in order to better understand Candida's dual lifestyle in the vagina. The potential of C. albicans to switch from the yeast cell morphology to its hyphal form is considered a key element in VVC pathogenesis. Candida spp...
March 2, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28124960/-investigation-of-in-vitro-metronidazole-resistance-in-the-clinical-isolates-of-trichomonas-vaginalis
#13
Hatice Ertabaklar, Senem Yaman Karadam, Erdoğan Malatyalı, Sema Ertuğ
Trichomonas vaginalis, a flagellated, urogenital anaerobic protozoon is reported as an important cause of vaginitis with a global distribution. Although metronidazole is the primary choice of drug for the treatment of trichomoniasis, the presence of resistant isolates from many different countries highlights the need of novel drugs for the treatment. Many studies from Turkey mostly dealing with the in vitro effects of compounds and natural products against T.vaginalis have been reported, however, only one study has been encountered searching the metronidazole resistance in a single T...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28063567/vulvovaginite-d%C3%A3-pistage-et-prise-en-charge-de-la-trichomonase-de-la-candidose-vulvovaginale-et-de-la-vaginose-bact%C3%A3-rienne
#14
Julie van Schalkwyk, Mark H Yudin
OBJECTIF: Analyser les données probantes et formuler des recommandations quant au dépistage et à la prise en charge de la candidose vulvovaginale, de la trichomonase et de la vaginose bactérienne. ISSUES: Parmi les issues évaluées, on trouve l'efficacité de l'antibiothérapie, les taux de guérison en ce qui concerne les infections simples et compliquées, et les implications de ces pathologies pendant la grossesse. RéSULTATS: La littérature publiée a été récupérée par l'intermédiaire de recherches menées dans MEDLINE, EMBASE, CINAHL et The Cochrane Library en juin 2013 au moyen d'un vocabulaire contrôlé (p...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27915337/quercetin-assists-fluconazole-to-inhibit-biofilm-formations-of-fluconazole-resistant-candida-albicans-in-in-vitro-and-in-vivo-antifungal-managements-of-vulvovaginal-candidiasis
#15
Mei Gao, Hui Wang, LiJuan Zhu
BACKGROUND: Vulvovaginal candidiasis (VVC) is a common gynecological disease. Candida albicans is believed to be mainly implicated in VVC occurrence, the biofilm of which is one of the virulence factors responsible for resistance to traditional antifungal agents especially to fluconazole (FCZ). Quercetin (QCT) is a dietary flavonoid and has been demonstrated to be antifungal against C. albicans biofilm. METHODS: 17 C. albicans isolates including 15 clinical ones isolated from VVC patients were employed to investigate the effects of QCT and/or FCZ on the inhibition of C...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27847193/extremely-low-gestational-age-and-very-low-birthweight-for-gestational-age-are-risk-factors-for-autism-spectrum-disorder-in-a-large-cohort-study-of-10-year-old-children-born-at-23-27-weeks-gestation
#16
MULTICENTER STUDY
Robert M Joseph, Steven J Korzeniewski, Elizabeth N Allred, T Michael O'Shea, Tim Heeren, Jean A Frazier, Janice Ware, Deborah Hirtz, Alan Leviton, Karl Kuban
BACKGROUND: No prospective cohort study of high-risk children has used rigorous exposure assessment and optimal diagnostic procedures to examine the perinatal antecedents of autism spectrum disorder separately among those with and without cognitive impairment. OBJECTIVE: We sought to identify perinatal factors associated with increased risk for autism spectrum disorder with and without intellectual disability (intelligence quotient <70) in children born extremely preterm...
March 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27833516/utility-of-laboratory-diagnosis-for-confirmation-of-the-syndromic-case-management-in-married-indian-women-with-vaginal-discharge
#17
Prabhav Aggarwal, Sonali Bhattar, Satyendra Kumar Sahani, Preena Bhalla
OBJECTIVE: WHO and NACO recommend treatment of STIs/RTIs on the basis syndromic case management (SCM), even without laboratory confirmation, which may lead to over-treatment. Thus, this study was conducted to evaluate the utility of laboratory diagnosis for confirmation of patients with vaginal discharge diagnosed on the basis of SCM. METHODOLOGY: 234 married women in reproductive age group, diagnosed as having vaginal discharge syndrome were included. Normal saline wet-mount slide preparations were made for detection of motile trichomonads...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27788740/-study-on-the-production-of-igg-derived-from-vaginal-epithelial-cells-and-the-effect-of-anti-candida-albicans
#18
X X Niu, T Li, Z H Liu
Objective: To investigate the function of IgG secreted by vaginal epithelial cells in natural resistance to vulvovaginal candidiasis. Methods: (1)Immunohistochemical method was used to determine the expression of IgG secreted by normal vaginal epithelial cells VK2/E6E7.(2)Samples were divided into three groups by different proportions of VK2/E6E7 cells to Candida albicans ,including Candida albicans: VK2/E6E7 cells were 1∶10, 1∶1[yeast+ cells(1∶10)group and yeast+ cells(1∶1)group]and VK2/E6E7 cells as blank control group...
October 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27751723/antifungal-effects-of-lavandula-binaludensis-and-cuminum-cyminum-essential-oils-against-candida-albicans-strains-isolated-from-patients-with-recurrent-vulvovaginal-candidiasis
#19
M H Minooeianhaghighi, L Sepehrian, H Shokri
OBJECTIVE: Recurrent vulvovaginal candidiasis (RVVC), which affects approximately 5% of women of reproductive age, is defined as 4 or more episodes of symptomatic Candida vaginitis within a year. The purposes of this study were to determine the chemical compositions and antifungal susceptibility of Cuminum cyminum (C. cyminum) and Lavandula binaludensis (L. binaludensis) essential oils and their combination against Candida albicans (C. albicans) strains isolated from patients with RVVC...
October 14, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/27744307/genetic-diversity-of-the-hwp1-gene-and-his3-ef3-cdc3-microsatellites-and-antifungal-susceptibility-profiles-of-candida-albicans-isolates-from-yaound%C3%A3-hiv-infected-patients
#20
Thierry Kammalac Ngouana, Pascal Drakulovski, Donika Krasteva, Rufin Kuipou Toghueo, Charles Kouanfack, Jacques Reynes, Eric Delaporte, Fabrice Fekam Boyom, Michèle Mallié, Sébastien Bertout
The molecular epidemiology and the antifungal susceptibility profiles of Candida albicans are scarce in Cameroon. Authors studied the genetic diversity and the antifungal susceptibility of C. albicans isolates from Yaoundé HIV-infected patients. Clinical isolates were obtained by mycological diagnosis of oropharyngeal swabs, stools, urine, and vaginal swabs from patients. C. albicans isolates were confirmed by the Light cycler real-time PCR of the ITS1 region of the 5.8s ribosomal DNA. The ABC genotypes and the Hwp1 gene amplification were carried out with specific primers...
October 14, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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