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https://www.readbyqxmd.com/read/29415485/experimental-in-vivo-models-of-candidiasis
#1
REVIEW
Esther Segal, Michael Frenkel
Candidiasis is a multifaceted fungal disease including mucosal-cutaneous, visceral, and disseminated infections caused by yeast species of the genus Candida. Candida infections are among the most common human mycoses. Candida species are the third to fourth most common isolates from bloodstream infections in neutropenic or immunocompromised hospitalized patients. The mucosal-cutaneous forms-particularly vaginal infections-have a high prevalence. Vaginitis caused by Candida species is the second most common vaginal infection...
February 6, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29401648/chitosan-loaded-into-a-hydrogel-delivery-system-as-a-strategy-to-treat-vaginal-co-infection
#2
Diego R Perinelli, Raffaella Campana, Athanasios Skouras, Giulia Bonacucina, Marco Cespi, Francesca Mastrotto, Wally Baffone, Luca Casettari
Polymeric hydrogels are common dosage forms designed for the topical administration of antimicrobial drugs to treat vaginal infections. One of the major advantages of using chitosan in these formulations is related to the intrinsic and broad antimicrobial activity exerted on bacteria and fungi by this natural polymer. Most vaginal yeast infections are caused by the pathogenic fungus Candida albicans. However, despite the anti-Candida activity towards and strains susceptibility to low molecular weight chitosan being documented, no information is available regarding the antimicrobial efficacy of mixed hydrogels in which chitosan is dispersed in a polymeric matrix...
February 3, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29380641/saccharomyces-cerevisiae-based-probiotic-as-novel-anti-fungal-and-anti-inflammatory-agent-for-therapy-of-vaginal-candidiasis
#3
E Gabrielli, E Pericolini, N Ballet, E Roselletti, S Sabbatini, P Mosci, A Cayzeele Decherf, F Pélerin, S Perito, P Jüsten, A Vecchiarelli
Previously we demonstrated that the treatment with live Saccharomyces cerevisiae exerts beneficial therapeutic effects against vaginal candidiasis. Here, we address potential mechanisms particularly examining the probiotic capacity to modulate both fungus and host-related factors. We show that the S. cerevisiae-based probiotic markedly affects the expression of virulence traits of Candida albicans such as aspartyl proteinases (SAPs) as well as hyphae-associated proteins Hwp1 and Ece1 in the vaginal cavity. On the host side, the probiotic suppression of the influx of neutrophils caused by the fungus into the vaginas of the mice is likely related to: (1) lower production of interleukin-8; and (2) inhibition of SAPs expression...
January 30, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29364944/associations-between-sexual-habits-menstrual-hygiene-practices-demographics-and-the-vaginal-microbiome-as-revealed-by-bayesian-network-analysis
#4
Noelle Noyes, Kyu-Chul Cho, Jacques Ravel, Larry J Forney, Zaid Abdo
The vaginal microbiome plays an influential role in several disease states in reproductive age women, including bacterial vaginosis (BV). While demographic characteristics are associated with differences in vaginal microbiome community structure, little is known about the influence of sexual and hygiene habits. Furthermore, associations between the vaginal microbiome and risk symptoms of bacterial vaginosis have not been fully elucidated. Using Bayesian network (BN) analysis of 16S rRNA gene sequence results, demographic and extensive questionnaire data, we describe both novel and previously documented associations between habits of women and their vaginal microbiome...
2018: PloS One
https://www.readbyqxmd.com/read/29354778/the-efficacy-of-gaseous-ozone-against-different-forms-of-candida-albicans
#5
M Zargaran, M Fatahinia, A Zarei Mahmoudabadi
Background and Purpose: Ozone is an inorganic molecule with effective antimicrobial properties. Clinical treatment of ozonated water was used for the elimination of Candidaalbicans, Enterococcus faecalis, endotoxins, and biofilms from root canals. In addition, its therapeutic effects for tinea pedis, ulcers, and leishmaniasis were investigated. The purpose of the present study was to evaluate the fungicidal effects of ozone on different forms of C. albicans. In addition, antifungal susceptibility profile of strains was assessed before and after exposure to ozone...
June 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29354774/in-vitro-antifungal-activity-of-essential-oils-extracted-from-plants-against-fluconazole-susceptible-and-resistant-candida-albicans
#6
F Katiraee, S Ahmadi Afshar, S F Rahimi Pirmahalleh, H Shokri
Background and Purpose: Candidaalbicans is the most common cause of candidal infections. Various studies have shown drug resistance among C. albicans isolates; thus, it is necessary to discover replacement treatments for Candida infections. In this study, we aimed to compare the effects of different essential oils against azoles-resistant and azoles-susceptible isolates. Materials and Methods: Twenty fluconazole-resistant and 20 susceptible C. albicans isolates obtained from oral, vaginal, and cutaneous tissues of patients with candidiasis were evaluated...
June 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29325916/proanthocyanidin-polymeric-tannins-from-stryphnodendron-adstringens-are-effective-against-fluconazole-resistant-candida-spp-and-treat-vaginal-candidiasis
#7
Aline Luiza Duarte de Freitas, Vanessa Kaplum, Diego Conrado Pereira Rossi, Leandro Buffoni Roque da Silva, Márcia de Souza Carvalho Melhem, Carlos Pelleschi Taborda, João Carlos Palazzo de Mello, Celso Vataru Nakamura, Kelly Ishida
ETHNOPHARMACOLOGICAL RELEVANCE: The stem bark of Stryphnodendron adstringens (Mart.) Coville is popularly used as anti-inflammatory, astringent and in the treatment of wounds and vaginal infections. Several pharmacological activities have been scientifically proven by "in vitro" and "in vivo" experimental assays for antibacterial, antiviral, antiprotozoan, anti-inflammatory and antioxidant. AIM OF THE STUDY: We investigated whether proanthocyanidin polymeric tannins from the Stryphnodendron adstringens steam bark with antifungal activity against Candida albicans in vitro are also active against planktonic and biofilm cells of Candida non-albicans (CNA, including fluconazole-resistant isolates) and are capable of controlling Candida vaginitis in vivo...
January 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29306553/knockout-of-autophagy-gene-atg5-in-mice-vaginal-cells-abrogates-cytokine-response-and-pathogen-clearance-during-vaginal-infection-of-candida-albicans
#8
Ankit Shroff, Roicy Sequeira, Vainav Patel, K V R Reddy
The female reproductive tract (FRT) presents a unique challenge to the mucosal immune system as it needs to monitor constantly for the presence of opportunistic pathogens amidst its commensal flora. During infection, autophagy plays a critical role in pathogen clearance, presentation of antigens and production of pro-inflammatory cytokines. However, no information is available that describes the role of autophagy in mouse vaginal infection of Candida albicans. The objective of our study is to evaluate the effect of autophagy gene, ATG5 knockout in vaginal cells in response to vaginal C...
December 28, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29223551/recent-advances-in-delivery-of-antifungal-agents-for-therapeutic-management-of-candidiasis
#9
REVIEW
Bhakti Sawant, Tabassum Khan
Candidiasis is a fungal infection caused by yeasts that belong to the genus Candida. There are over twenty species of Candida yeasts that can cause infection in humans, the most common of which is Candida albicans. Candida yeasts normally reside in the intestinal tract and can be found on mucous membranes and skin without causing infection; however, overgrowth of these organisms can cause symptoms to develop. Presence of other diseases that compromises the patient's immunity makes it more difficult to treat...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29126739/discovery-of-simplified-sampangine-derivatives-as-novel-fungal-biofilm-inhibitors
#10
Na Liu, Hua Zhong, Jie Tu, Zhigan Jiang, Yanjuan Jiang, Yan Jiang, Yuanying Jiang, Jian Li, Wannian Zhang, Yan Wang, Chunquan Sheng
Lack of novel antifungal agents and severe drug resistance have led to high incidence and associated mortality of invasive fungal infections. To tackle the challenges, novel antifungal agents with new chemotype, fungicidal activity and anti-resistant potency are highly desirable. On the basis of our previously identified simplified analogue of antifungal natural product sampangine, systemic structure-activity relationships were clarified and two novel derivatives showed promising features as novel antifungal lead compounds...
October 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28969122/comparative-study-on-the-vaginal-flora-and-incidence-of-asymptomatic-vaginosis-among-healthy-women-and-in-women-with-infertility-problems-of-reproductive-age
#11
Geethavani Babu, Balamuru Ganvelu Singaravelu, R Srikumar, Sreenivasalu V Reddy, Afraa Kokan
INTRODUCTION: The normal vaginal flora is highly complex, dominated by lactobacilli of doderlein that plays a vital role in maintaining the women's health and inhibits other pathogenic microorganisms. Fluctuation in local environment or exposure to any exogenous and endogenous sources changes the vaginal flora over a period of time. Disruption of the vaginal ecosystem changes the microflora of the healthy vagina, altering the pH and predisposing to lower reproductive tract infections...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28946854/cervical-precancerous-changes-and-selected-cervical-microbial-infections-kiambu-county-kenya-2014-a-cross-sectional-study
#12
Evalyne Wambui Kanyina, Lucy Kamau, Margaret Muturi
BACKGROUND: Cervical cancer is the predominant cancer among women in Kenya and second most common in women in developing regions. Population-based cytological screening and early treatment reduces morbidity and mortality associated with the cancer. We determined the occurrence of cervical precancerous changes and cervical microbial infections (Trichomonas vaginalis, Candida albicans, Neisseria gonorrhea and Actinomyces) among women attending Family Health Option Kenya (FHOK) clinic in Thika...
September 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28939305/prevalence-of-vulvovaginal-candidiasis-in-pregnancy-at-three-health-centers-in-burkina-faso
#13
I Sangaré, C Sirima, S Bamba, A Zida, M Cissé, W W Bazié, S Sanou, B Dao, H Menan, R T Guiguemdé
INTRODUCTION: Pregnant women are more susceptible to vaginal colonization and infection by yeast. The role of Candida colonization in the occurrence of preterm birth is well established. The knowledge of local epidemiology and identification of risk factors for preterm birth is important for the prevention and management strategies. The purpose of the study was to determine the prevalence of Candida sp. in vaginal swabs of pregnant women. METHODS: Pregnant women attending routine antenatal visits in three primary health centres in Bobo-Dioulasso (Burkina Faso) were enrolled into a cross-sectional study carried out from February to April 2015...
September 20, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28927765/recurrent-vulvovaginal-candidiasis
#14
REVIEW
Freida Blostein, Elizabeth Levin-Sparenberg, Julian Wagner, Betsy Foxman
PURPOSE: Recurrent vulvovaginal candidiasis (RVVC), multiple episodes of vulvovaginal candidiasis (VVC; vaginal yeast infection) within a 12-month period, adversely affects quality of life, mental health, and sexual activity. Diagnosis is not straightforward, as VVC is defined by the combination of often nonspecific vaginal symptoms and the presence of yeast-which is a common vaginal commensal. Estimating the incidence and prevalence is challenging: most VVC is diagnosed and treated empirically, the availability for purchase of effective therapies over the counter enables self-diagnosis and treatment, and the duration of the relatively benign VVC symptoms is short, introducing errors into any estimates relying on medical records or patient recall...
September 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28831255/stratum-corneum-lipid-liposome-encapsulated-panomycocin-preparation-characterization-and-the-determination-of-antimycotic-efficacy-against-candida-spp-isolated-from-patients-with-vulvovaginitis-in-an-in-vitro-human-vaginal-epithelium-tissue-model
#15
Fatih İzgü, Günce Bayram, Kübra Tosun, Demet İzgü
In this study, a liposomal lyophilized powder formulation of panomycocin was developed for therapeutic purposes against vulvovaginal candidiasis which affects 80% of women worldwide. Panomycocin is a potent antimycotic protein secreted by the yeast Wickerhamomyces anomalus NCYC 434. This study involved the preparation of panomycocin-loaded stratum corneum lipid liposomes (SCLLs), characterization of the SCLLs, and determination of antimycotic efficacy of the formulation against Candida albicans and Candida glabrata clinical vaginal isolates in a human vaginal epithelium tissue model...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28809155/microbe-profile-candida-albicans-a-shape-changing-opportunistic-pathogenic-fungus-of-humans
#16
Neil A R Gow, Bhawna Yadav
(a) Morphotypes of Candida albicans (blue sector, vegetative forms; pink sector, forms related to mating or changes in ploidy). Cell types shown include: budding yeast cells; elongated conjoined yeasts forming pseudohyphae; parallel-sided hyphae; chlamydospores formed from suspensor cells; enlarged goliath cells formed under zinc deprivation (unpublished study, image from Duncan Wilson); intestinal gut form cells (image from Suzanne Noble); mating competence defined by white-grey-opaque cell transitions (images from Guanghua Huang); elongated chemotactic shmoo-mating projections leading to tetraploid zygote formation (images from David Soll and Karla Daniels); trimera formed by unequal chromosome segregation under antifungal exposure (image from Judith Berman)...
August 15, 2017: Microbiology
https://www.readbyqxmd.com/read/28793015/virulence-factors-and-genetic-variability-of-vaginal-candida-albicans-isolates-from-hiv-infected-women-in-the-post-highly-active-antiretroviral-era
#17
Pâmela Cristina Mastellaro Delvas Zanni, Patrícia de Souza Bonfim-Mendonça, Melyssa Negri, Sandra Sayuri Nakamura, Lucélia Donatti, Terezinha Inez Estivalet Svidzinski, Márcia Edilaine Lopes Consolaro
Vulvovaginal candidiasis (VVC) in HIV-infected (HIV+) women is a serious public health problem. However, little is known about the virulence mechanisms of vaginal Candida albicans from HIV+ women in the post-highly active antiretroviral therapy (HAART) era. Here, we report a comparative analysis of the expression of key virulence factors and genetic variability of 26 vaginal C. albicans strains isolated from HIV+ women undergoing HAART and 18 from HIV-uninfected (HIV-) women. In general, we observed that C...
2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28774749/sexual-and-reproductive-health-behaviors-and-experiences-reported-by-young-women-with-cystic-fibrosis
#18
Traci M Kazmerski, Gregory S Sawicki, Elizabeth Miller, Kelley A Jones, Kaleab Z Abebe, Lisa K Tuchman, Sigrid Ladores, Ronald C Rubenstein, Scott D Sagel, Daniel J Weiner, Joseph M Pilewski, David M Orenstein, Sonya Borrero
BACKGROUND: The prevalence of general and disease-specific sexual and reproductive health (SRH) concerns is unknown in the United States (U.S.) female CF population. This study aimed to describe and compare the SRH experiences and behaviors of young women with CF with the general U.S. POPULATION: HASH(0x39a09d8) METHODS: Young women with CF ages 15-24years from five geographically diverse U.S. CF centers participated in a survey investigating SRH...
August 1, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28771140/cell-damage-caused-by-vaginal-candida-albicans-isolates-from-women-with-different-symptomatologies
#19
Daniella Renata Faria, Karina Mayumi Sakita, Luciene Setsuko Akimoto-Gunther, Érika Seki Kioshima, Terezinha Inez Estivalet Svidzinski, Patrícia de Souza Bonfim-Mendonça
The present study aimed to characterize cell damage caused by vaginal Candida albicans isolates from women with different symptomatologies. It was evaluated 12 clinical isolates of C. albicans from vaginal samples: 4 from asymptomatic women (AS), 4 from women with a single episode of vulvovaginal candidiasis (VVC) and 4 from women with recurrent vulvovaginal candidiasis (RVVC). We evaluated the ability of C. albicans to adhere to human cervical cancer cells (SiHa), the yeast-SiHa cell interactions and cell damage...
August 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28730269/emergence-of-candida-glabrata-in-vulvovaginal-candidiasis-should-be-attributed-to-selective-pressure-or-virulence-ability
#20
Sandra Sayuri Nakamura-Vasconcelos, Adriana Fiorini, Pamela Delvas Zanni, Patrícia de Souza Bonfim-Mendonça, Janine Ribeiro Godoy, Adriana Araújo Almeida-Apolonio, Marcia Edilaine Lopes Consolaro, Terezinha Inez Estivalet Svidzinski
PURPOSE: Vulvovaginal candidiasis (VVC) is one of the most frequent female genital disorders and Candida glabrata is the second most common agent. Current study was aimed to study the susceptibility to antifungal agents of C. glabrata isolated from vaginal samples and some virulence attributes in order to better understand why this species is emerging as the main VVC agents. METHODS: A total of 60 C. glabrata vaginal isolates were included in this study. Firstly they were screened by susceptibility tests to antifungal agents...
July 20, 2017: Archives of Gynecology and Obstetrics
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