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https://www.readbyqxmd.com/read/28345545/diagnostic-significance-of-mycobacterium-tuberculosis-t-cell-assays-for-active-tuberculosis
#1
Wei-Xia Xuan, Ting-Ting Lu, Zheng Wang, Yun-Xia An, Xiao-Ju Zhang
BACKGROUND: Active tuberculosis (TB) with negative results of sputum smear is difficult to be identified. Till now, there is no effective and noninvasive diagnostic method. This study evaluated the diagnostic power of Mycobacterium tuberculosis T-cell (T.SPOT®.TB) assays for active TB. METHODS: We retrospectively screened 450 suspected TB patients that were hospitalized in the Respiratory Department of Henan Province People's Hospital from June 2015 to June 2016...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28345213/caries-experience-of-children-in-primary-schools-with-long-term-tooth-brushing-programs-a-pilot-australian-study
#2
T Cakar, L Harrison-Barry, M L Pukallus, S Kazoullis, W K Seow
OBJECTIVE: The aim of this study was to evaluate a primary school-based tooth brushing (TB) program conducted in a low socio-economic area of Queensland, Australia, to determine its effectiveness in reducing caries. METHODS: Records kept at the central dental clinic of the district were used to analyse the caries experience (decayed, missing, filled teeth [dmft/DMFT]) and caries prevalence in children from two schools with long-term TB programs (TB) (N=1191) and three Non-TB schools (N=553)...
March 26, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28337993/evaluation-of-5-novel-protein-biomarkers-for-the-rapid-diagnosis-of-pulmonary-and-extra-pulmonary-tuberculosis-preliminary-results
#3
Amit Singh, Anil Kumar Gupta, Krishnamoorthy Gopinath, Pawan Sharma, Sarman Singh
Improved methods are required for the early and accurate diagnosis of tuberculosis, especially in the patients with smear-negative disease. Several biomarkers have been tried but most have shown poor sensitivity or specificity. In present study we aimed to evaluate the diagnostic utility of five novel antigens identified earlier by us. This is an initial study conducted on 250 subjects. The five recombinant antigens, named as rSS1 (Rv2145c), rSS2 (Rv0164), rSS3 (Rv1437), rSS4 (Rv1827) and rSS5 (Rv2970c), were expressed in pQE-30 expression vector, purified and their sero-diagnostic efficacy was evaluated in an unblinded manner using dot-blot and ELISA methods...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183335/efficacy-of-vitamin-d3-supplementation-in-reducing-incidence-of-pulmonary-tuberculosis-and-mortality-among-hiv-infected-tanzanian-adults-initiating-antiretroviral-therapy-study-protocol-for-a-randomized-controlled-trial
#4
Christopher R Sudfeld, Ferdinand Mugusi, Said Aboud, Tumaini J Nagu, Molin Wang, Wafaie W Fawzi
BACKGROUND: HIV-infected adults initiating antiretroviral therapy (ART) in sub-Saharan Africa continue to experience high rates of morbidity and mortality during the initial months of treatment. Observational studies in high-income and resource-limited settings indicate that HIV-infected adults with low vitamin D levels may be at increased risk of mortality, HIV disease progression, and incidence of pulmonary tuberculosis (TB). As a result, vitamin D3 supplementation may improve survival and treatment outcomes for HIV-infected adults initiating ART...
February 10, 2017: Trials
https://www.readbyqxmd.com/read/28166911/health-related-quality-of-life-among-tuberculosis-patients-under-revised-national-tuberculosis-control-programme-in-rural-and-urban-puducherry
#5
S Ramkumar, S Vijayalakshmi, N Seetharaman, R Pajanivel, A Lokeshmaran
BACKGROUND: Globally, tuberculosis (TB) continues to be the major public health problem. Limited research is carried out on the impact of the disease on health-related quality of life (HR-QoL). The study aims to assess the HR-QoL among TB patients during and after Directly Observed Treatment Short-course (DOTS) therapy and to compare the HR-QoL of these patients with matched neighbourhood controls. METHODOLOGY: A community-based longitudinal study was conducted in Ariyankuppam and Bahour communes of Puducherry from January 2014 to April 2015...
January 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28139869/effect-of-pulmonary-tuberculosis-on-clinical-outcomes-of-long-term-dialysis-patients-pre-and-post-dots-implementation-in-taiwan
#6
Kuan-Jen Bai, Kuan-Chih Huang, Chih-Hsin Lee, Chao-Hsiun Tang, Ming-Chih Yu, Yuh-Mou Sue
BACKGROUND AND OBJECTIVE: The link between tuberculosis (TB) and dialysis is known; however, the impact of TB on the clinical outcomes remains to be elucidated. This study aims to determine the clinical consequences of pulmonary TB among patients under long-term dialysis. METHODS: A retrospective propensity-scores matched (1:4) cohort study was conducted by retrieving patient data for pulmonary TB after long-term dialysis commencement from the Taiwan National Health Insurance Research Database between 1999 and 2013...
January 31, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28125693/incremental-yield-of-including-determine-tb-lam-assay-in-diagnostic-algorithms-for-hospitalized-and-ambulatory-hiv-positive-patients-in-kenya
#7
Helena Huerga, Gabriella Ferlazzo, Paolo Bevilacqua, Beatrice Kirubi, Elisa Ardizzoni, Stephen Wanjala, Joseph Sitienei, Maryline Bonnet
BACKGROUND: Determine-TB LAM assay is a urine point-of-care test useful for TB diagnosis in HIV-positive patients. We assessed the incremental diagnostic yield of adding LAM to algorithms based on clinical signs, sputum smear-microscopy, chest X-ray and Xpert MTB/RIF in HIV-positive patients with symptoms of pulmonary TB (PTB). METHODS: Prospective observational cohort of ambulatory (either severely ill or CD4<200cells/μl or with Body Mass Index<17Kg/m2) and hospitalized symptomatic HIV-positive adults in Kenya...
2017: PloS One
https://www.readbyqxmd.com/read/28108375/the-role-of-pattern-recognition-receptors-in-lung-sarcoidosis
#8
Esmaeil Mortaz, Ian M Adcock, Atefhe Abedini, Arda Kiani, Mehdi Kazempour-Dizaji, Masoud Movassaghi, Johan Garssen
Sarcoidosis is a granulomatous disorder of unknown etiology. Infection, genetic factors, autoimmunity and an aberrant innate immune system have been explored as potential causes of sarcoidosis. The etiology of sarcoidosis remains unknown, and it is thought that it might be caused by an infectious agent in a genetically predisposed, susceptible host. Inflammation results from recognition of evolutionarily conserved structures of pathogens (Pathogen-associated molecular patterns, PAMPs) and/or from reaction to tissue damage associated patterns (DAMPs) through recognition by a limited number of germ line-encoded pattern recognition receptors (PRRs)...
January 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28038487/-the-role-and-contribution-of-chief-physician-matija-perak-1914%C3%A2-1992-to-the-foundation-and-development-of-phtisiology-in-petrinja-1946%C3%A2-1978
#9
Boris Vrga
The study shows the contribution of Matija Perak to the development of phthisiological service in Petrinja and the suppression of TB in the Sisak - Banija region in the period from 1946 to 1978. Having obtained data from the archive documents, it was possible to reconstruct his curative and preventive activities in the suppression of morbidity and mortality from TB in the Sisak - Banija region. His organizational and managerial, professional-scientific and publicistic work is highlighted, as well as his role in the reorientation of the profession towards chronic non-TB diseases and the education of new generations of phthisiologists in Petrinja...
December 2016: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/27998493/periodontal-status-of-tuberculosis-patients-is-there-a-two-way-link
#10
Anamika Sharma, Harshita Garg, Shivi Khattri, Shatakshi Sharma
BACKGROUND: The influence of systemic disorders on periodontal tissues is well established. Amongst various chronic debilitating diseases, tuberculosis (TB) is one of the major health problems in most developing countries. Although it has a definite affinity for the lungs, it can affect any part of the body including the oral cavity. TB and periodontitis are the two distinct disease processes. But environmental and biological factors play a key role in etiopathogenesis of both the diseases...
October 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27919693/performance-evaluation-of-xpert-mtb-rif-in-a-moderate-tuberculosis-incidence-compared-with-taqman-mtb-and-trcrapid-m-tb
#11
Kazunari Tsuyuguchi, Hideaki Nagai, Kenji Ogawa, Tomoshige Matsumoto, Kozo Morimoto, Akiko Takaki, Satoshi Mitarai
Xpert MTB/RIF is an automated nucleic acid amplification test (NAT) that can detect the presence of Mycobacterium tuberculosis complex (MTC) in clinical specimens as well as rifampicin (RIF) resistance resulting from rpoB mutation. Despite its high sensitivity and specificity for diagnosing tuberculosis (TB) with or without RIF resistance, the clinical performance of the test is variable. In this study, we evaluated the performance of Xpert MTB/RIF in a setting of moderate TB burden and high medical resources...
February 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27880044/tuberculosis-airway-obstruction-and-mortality-in-a-finnish-population
#12
Tiina Mattila, Markku Heliövaara, Harri Rissanen, Paul Knekt, Pauli Puukka, Tuula Vasankari
There is little long-term follow-up data concerning the association between past pulmonary tuberculosis (TB), airway obstruction and mortality. We aimed to analyse a national health examination survey data from 6701 adult Finns undergoing spirometry between 1978 and 1980 (follow-up through 2013). We identified TB either through a disease history or by a TB-indicative scar on a chest x-ray. We specified obstruction using the lower limit of normal (LLN) and classified severity using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1-4...
November 23, 2016: COPD
https://www.readbyqxmd.com/read/27858862/utility-of-t-cell-interferon-%C3%AE-release-assays-for-the-diagnosis-of-female-genital-tuberculosis-in-a-tertiary-referral-hospital-in-beijing-china
#13
Xiaoqing Liu, Sainan Bian, Xinhe Cheng, Wenze Wang, Qinjie Tian, Lifan Zhang, Yueqiu Zhang, Xiaochun Shi, Yao Zhang, Zhiyong Liang
Diagnosis of female genital tuberculosis (FGTB) remains a challenge. The aim of this study was to evaluate the diagnostic value of T-SPOT.TB on peripheral blood mononuclear cells (PBMCs) for diagnosing FGTB in an area with high TB burden.Patients with suspected FGTB were enrolled consecutively between August 2010 and August 2015. T-SPOT.TB on PBMCs and histopathology were performed in all patients. T-SPOT.TB results were evaluated against patients' final diagnosis of FGTB which was made based on clinical manifestations, radiology, microbiological and histopathological evaluation, and response to anti-TB treatment...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27795917/hmgb1-level-in-cerebrospinal-fluid-as-a-complimentary-biomarker-for-the-diagnosis-of-tuberculous-meningitis
#14
Yan Chen, Jun Zhang, Xiaofei Wang, Yu Wu, Li Zhu, Longkun Lu, Qian Shen, Yanghua Qin
PURPOSE: High mobility group box-1 (HMGB1) is a proinflammatory, DAMP protein that participates in many pathological conditions. In this study, we evaluated the usability of CSF HMGB1 as a biomarker for the diagnosis of tuberculous meningitis (TBM). METHODS: A total of 59 TBM patients and 169 control patients were included in our study. CSF samples were obtained and analyzed for HMGB1 using a commercial ELISA kit. RESULTS: The mean CSF HMGB1 was 19...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27684274/utility-of-macrophage-activated-marker-cd163-for-diagnosis-and-prognosis-in-pulmonary-tuberculosis
#15
Yuzo Suzuki, Masahiro Shirai, Kazuhiro Asada, Seiichi Miwa, Masato Karayama, Yutaro Nakamura, Naoki Inui, Toshihiro Shirai, Hiroshi Hayakawa, Satoshi Baba, Takafumi Suda
RATIONALE: Among infectious diseases, tuberculosis (TB) is a leading cause of death worldwide. Accumulated knowledge has revealed that macrophages are deeply involved in the progression and pathogenesis of TB. We hypothesized that the evaluation of a macrophage activation marker may be useful in the diagnosis and assessment of pulmonary TB. OBJECTIVES: To examine the utility of the macrophage activation marker soluble CD163 (sCD163) as a diagnostic tool and measure of disease severity for pulmonary TB and tuberculous pleurisy...
January 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27633798/the-diagnostic-accuracy-of-pericardial-and-urinary-lipoarabinomannan-lam-assays-in-patients-with-suspected-tuberculous-pericarditis
#16
Shaheen Pandie, Jonathan G Peter, Zita S Kerbelker, Richard Meldau, Grant Theron, Ureshnie Govender, Mpiko Ntsekhe, Keertan Dheda, Bongani M Mayosi
We evaluated the diagnostic accuracy of urinary and pericardial fluid (PF) lipoarabinomannan (LAM) assays in tuberculous pericarditis (TBP). From October 2009 through September 2012, 151 patients with TBP were enrolled. Mycobacterium tuberculosis culture and/or pericardial histology were the reference standard for definite TBP. 49% (74/151), 33.1% (50/151) and 17.9% (27/151) of patients had definite-, probable-, and non-TB respectively; 69.5% (105/151) were HIV positive. LAM ELISA had the following sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, positive predictive value and negative predictive values (95% confidence interval): urinary - 17...
September 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27574764/plasma-adenosine-deaminase-enzyme-reduces-with-treatment-of-pulmonary-tuberculosis-in-nigerian-patients-indication-for-diagnosis-and-treatment-monitoring
#17
O Ige, V F Edem, O G Arinola
Tuberculosis(TB)-specific host biomarkers for diagnosis and monitoring of treatment response have been identified as priorities for TB research. Macrophage and T cell lymphocytes play vital roles in Mycobacterium tuberculosis immune response and their associated biomarkers could form good candidates for diagnosis and treatment monitoring. The enzyme adenosine deaminase (ADA) is produced mainly by monocytes and macrophages and increase in biological fluids in the course of infection with microorganisms infecting macrophages...
August 30, 2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/27553414/immunoglobulin-g-response-to-mammalian-cell-entry-1a-mce1a-protein-as-biomarker-of-active-tuberculosis
#18
Iukary Takenami, Carolina C de Oliveira, Filipe R Lima, Jéssica Soares, Almério Machado, Lee W Riley, Sérgio Arruda
Cell wall components are major determinants of virulence of Mycobacterium tuberculosis and they contribute to the induction of both humoral and cell-mediated immune response. The mammalian cell entry protein 1A (Mce1A), in the cell wall of M. tuberculosis, mediates entry of the pathogen into mammalian cells. Here, we examined serum immunoglobulin levels (IgA, IgM and total IgG) against Mce1A as a potential biomarker for diagnosis and monitoring tuberculosis (TB) treatment response. Serum samples of 39 pulmonary TB patients and 65 controls (15 healthy household contacts, 19 latently infected household contacts, 13 non-TB and 18 leprosy patients) were screened by ELISA...
September 2016: Tuberculosis
https://www.readbyqxmd.com/read/27553407/discriminative-expression-of-whole-blood-genes-in-hiv-patients-with-latent-and-active-tb-in-ethiopia
#19
Desta Kassa, Leonie Ran, Wilco de Jager, Theo van den Broek, Ronald Jacobi, Muluberhan Mekonen, Tsehaynesh Messele, Mariëlle C Haks, Tom H M Ottenhoff, Debbie van Baarle
BACKGROUND: Transcriptomic host biomarkers could assist in developing effective diagnostics, vaccines and therapeutics for tuberculosis (TB). However, different biomarkers may be discriminatory in different populations depending on the host and bacillary genetics and HIV infection, and need to be addressed. METHODS: The expression levels of 45 genes that are known to be involved in or affected by TB pathogenesis were analyzed using dual color Reverse Transcriptase Multiplex Ligation-dependent Probe Amplification (dcRT-MLPA) assay in whole blood of 106 HIV positive individuals including active TB patients (TB(+)HIV(+), n = 29), and non TB patients that are tuberculin skin test positive (TST+) (TST(+)HIV(+), n = 26), or TST negative (TST(-)HIV(+), n = 51)...
September 2016: Tuberculosis
https://www.readbyqxmd.com/read/27462354/usefulness-of-interferon-%C3%AE-release-assay-for-the-diagnosis-of-latent-tuberculosis-infection-in-young-children
#20
Ki Wook Yun, Young Kwang Kim, Hae Ryun Kim, Mi Kyung Lee, In Seok Lim
PURPOSE: Latent tuberculosis infection (LTBI) in young children may progress to severe active tuberculosis (TB) disease and serve as a reservoir for future transmission of TB disease. There are limited data on interferon-γ release assay (IGRA) performance in young children, which our research aims to address by investigating the usefulness of IGRA for the diagnosis of LTBI. METHODS: We performed a tuberculin skin test (TST) and IGRA on children who were younger than 18 years and were admitted to Chung-Ang University Hospital during May 2011-June 2015...
June 2016: Korean Journal of Pediatrics
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