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https://www.readbyqxmd.com/read/29464970/comparative-evaluation-of-genexpert-mtb-rif-and-multiplex-pcr-targeting-mpb64-and-is6110-for-the-diagnosis-of-pleural-tb
#1
Suman Sharma, Bhawna Dahiya, Vishnubhatla Sreenivas, Netrapal Singh, Ankush Raj, Abhishek Sheoran, Aparna Yadav, Krishna B Gupta, Promod K Mehta
AIM: Diagnosis of pleural TB poses serious challenges due to paucibacillary nature of specimens and there is an urgent need to devise a reliable diagnostic test. METHODS: We compared GeneXpert Mycobacterium tuberculosis/rifampin assay and the multiplex PCR (M-PCR) targeting mpb64 (Rv1980c) and IS6110 in pleural fluids (n = 78) of pleural TB patients and non-TB controls. RESULTS: The sensitivities of 89.6 and 33.3%, and specificities of 96...
February 21, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29395556/outcomes-of-arthroscopic-management-of-trochanteric-bursitis-in-patients-with-femoroacetabular-impingement-a-comparison-of-two-matched-patient-groups
#2
Alexander R Vap, Justin J Mitchell, Karen K Briggs, Shannen C McNamara, Marc J Philippon
PURPOSE: To determine the prevalence of chronic trochanteric bursitis (TB) in patient being treated for femoroacetabular impingement (FAI) and determine the effectiveness of arthroscopic bursectomy and iliotibial band lengthening (AB-ITB-L) at the time of hip arthroscopy for FAI. METHODS: Patients diagnosed with primary FAI and chronic TB were included in the study. Patients were included if they underwent hip arthroscopy with labral repair, femoral and/or acetabular osteoplasty, and AB-ITB-L...
January 27, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29382589/the-prevalence-and-determinants-of-active-tuberculosis-among-diabetes-patients-in-cape-town-south-africa-a-high-hiv-tb-burden-setting
#3
Natacha Berkowitz, Adaeze Okorie, Rene Goliath, Naomi Levitt, Robert J Wilkinson, Tolu Oni
AIMS: Studies addressing the association between diabetes mellitus (DM) and tuberculosis (TB) in sub-Saharan Africa are limited. We assessed the prevalence of active TB among DM patients at a primary care clinic, and identified risk factors for prevalent TB. METHODS: A cross-sectional study was conducted in adult DM patients attending a clinic in Khayelitsha, Cape Town. Participants were screened for active TB (symptom screening and microbiological diagnosis) and HIV...
January 27, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29363640/interferon-gamma-release-assay-is-not-appropriate-for-the-diagnosis-of-active-tuberculosis-in-high-burden-tuberculosis-settings-a-retrospective-multicenter-investigation
#4
Wan-Li Kang, Gui-Rong Wang, Mei-Ying Wu, Kun-Yun Yang, A Er-Tai, Shu-Cai Wu, Shu-Jun Geng, Zhi-Hui Li, Ming-Wu Li, Liang Li, Shen-Jie Tang
BACKGROUND: Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis, but the results from different high TB-endemic countries are different. The aim of this study was to investigate the value of IGRA in the diagnosis of active pulmonary TB (PTB) in China. METHODS: We conducted a large-scale retrospective multicenter investigation to further evaluate the role of IGRA in the diagnosis of active PTB in high TB-epidemic populations and the factors affecting the performance of the assay...
February 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29318113/application-values-of-t-spot-tb-in-clinical-rapid-diagnosis-of-tuberculosis
#5
Feng Zhu, Qinfang Ou, Jian Zheng
Background: This paper aims to explore the application value of tuberculosis-specific enzyme-linked immunospot assay (T-SPOT.TB) in the diagnosis of tuberculosis. Methods: Fifty one patients with tuberculosis (TB) admitted to Wuxi No.5 People's Hospital, Wuxi, China from June 2015 to June 2017 were selected as the TB group, and 40 patients without tuberculosis admitted in the same period were randomly selected as the non-TB group. Patients in the two groups received T-SPOT...
January 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29297451/cxcr3-ligands-in-pleural-fluid-as-markers-for-the-diagnosis-of-tuberculous-pleural-effusion
#6
W Chung, Y Jung, K Lee, J Park, S Sheen, K Park
SETTING: A tertiary care academic medical centre. OBJECTIVE: To evaluate the clinical usefulness of C-X-C motif chemokine receptor 3 (CXCR3) ligands in tuberculous pleural effusion (TPE). DESIGN: We recruited 336 patients with pleural effusion due to various causes. Concentrations of interferon-gamma (IFN-γ) and the CXCR3 ligands CXCL9 and CXCL11 were determined using enzyme immunoassays; adenosine deaminase (ADA) activity was measured in pleural fluid and serum...
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29237757/urine-lipoarabinomannan-glycan-in-hiv-negative-patients-with-pulmonary-tuberculosis-correlates-with-disease-severity
#7
Luisa Paris, Ruben Magni, Fatima Zaidi, Robyn Araujo, Neal Saini, Michael Harpole, Jorge Coronel, Daniela E Kirwan, Hannah Steinberg, Robert H Gilman, Emanuel F Petricoin, Roberto Nisini, Alessandra Luchini, Lance Liotta
An accurate urine test for pulmonary tuberculosis (TB), affecting 9.6 million patients worldwide, is critically needed for surveillance and treatment management. Past attempts failed to reliably detect the mycobacterial glycan antigen lipoarabinomannan (LAM), a marker of active TB, in HIV-negative, pulmonary TB-infected patients' urine (85% of 9.6 million patients). We apply a copper complex dye within a hydrogel nanocage that captures LAM with very high affinity, displacing interfering urine proteins. The technology was applied to study pretreatment urine from 48 Peruvian patients, all negative for HIV, with microbiologically confirmed active pulmonary TB...
December 13, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29226173/long-term-outcome-of-antiretroviral-treatment-in-patients-with-and-without-concomitant-tuberculosis-receiving-health-center-based-care-results-from-a-prospective-cohort-study
#8
Anton Reepalu, Taye Tolera Balcha, Erik Sturegård, Patrik Medstrand, Per Björkman
Background: In order to increase treatment coverage, antiretroviral treatment (ART) is provided through primary health care in low-income high-burden countries, where tuberculosis (TB) co-infection is common. We investigated the long-term outcome of health center-based ART, with regard to concomitant TB. Methods: ART-naïve adults were included in a prospective cohort at Ethiopian health centers and followed for up to 4 years after starting ART. All participants were investigated for active TB at inclusion...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29216851/what-does-igra-testing-add-to-the-diagnosis-of-ocular-tuberculosis-a-bayesian-latent-class-analysis
#9
Rupesh Agrawal, Robert Grant, Bhaskar Gupta, Dinesh Visva Gunasekeran, Julio J Gonzalez-Lopez, Peter K F Addison, Mark Westcott, Carlos E Pavesio
BACKGROUND: To evaluate the contribution made to the diagnostic work-up for patients with suspected ocular tuberculosis (TB) by QuantiFERON-TB Gold In-Tube (QFT) tests using latent class analysis model. METHODS: A single centre retrospective cohort study. A Bayesian latent class model was constructed on the basis of demographics, phenotypes and test results from patients attending a tertiary referral center in the UK. This estimated the probability of ocular TB for each patient in two versions, first with and then without QFT...
December 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29179784/underweight-increases-the-risk-of-early-death-in-tuberculosis-patients
#10
Yung-Feng Yen, Fu-I Tung, Bo-Lung Ho, Yun-Ju Lai
Evidence regarding the association between BMI and mortality in tuberculosis (TB) patients is limited and inconsistent. We investigated the impact of BMI on TB-specific and non-TB-specific mortality with respect to different timing of death. All Taiwanese adults with TB in Taipei were included in a retrospective cohort study in 2012-2014. Multinomial Cox proportional hazards regression was used to evaluate the associations between BMI, cause-specific mortality and timing of death. Of 2410 eligible patients, 86·0 % (2061) were successfully treated, and TB-specific and non-TB-specific mortality occurred for 2·2 % (54) and 13·9 % (335), respectively...
November 28, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29176894/horizontal-acquisition-of-a-hypoxia-responsive-molybdenum-cofactor-biosynthesis-pathway-contributed-to-mycobacterium-tuberculosis-pathoadaptation
#11
Florence Levillain, Yannick Poquet, Ludovic Mallet, Serge Mazères, Michael Marceau, Roland Brosch, Franz-Christoph Bange, Philip Supply, Axel Magalon, Olivier Neyrolles
The unique ability of the tuberculosis (TB) bacillus, Mycobacterium tuberculosis, to persist for long periods of time in lung hypoxic lesions chiefly contributes to the global burden of latent TB. We and others previously reported that the M. tuberculosis ancestor underwent massive episodes of horizontal gene transfer (HGT), mostly from environmental species. Here, we sought to explore whether such ancient HGT played a part in M. tuberculosis evolution towards pathogenicity. We were interested by a HGT-acquired M...
November 27, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29174965/il-6-release-of-rv0183-antigen-stimulated-whole-blood-is-a-potential-biomarker-for-active-tuberculosis-patients
#12
Yongliang Liu, Xiaofei Li, Wei Liu, Yang Liu, Zhouyue Zhong, Lili Wang, ShengXiang Ge, Jun Zhang, Ningshao Xia
OBJECTIVE: New tests for diagnosing active tuberculosis (aTB) are urgently needed, and TB antigen-specific cell-mediated immunity can be expected to develop new testing methods of aTB. MATERIALS AND METHODS: Rv0183 protein, the only monoglyceride lipase identified in mycobacteria, was used to stimulate freshly heparin-treated whole blood. The Rv0183-specific cytokines/chemokines response associated with aTB was screened firstly with 4 aTB patients and 4 LTBIs, and further evaluated in 192 suspected aTB patients and 372 healthy individuals...
November 24, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29138284/rapid-diagnosis-of-pulmonary-tuberculosis-and-detection-of-drug-resistance-by-combined-simultaneous-amplification-testing-and-reverse-dot-blot
#13
Yiwen Chen, Lahong Zhang, Liquan Hong, Xian Luo, Juping Chen, Leiming Tang, Jiahuan Chen, Xia Liu, Zhaojun Chen
AIMS: Making a correct and rapid diagnosis is essential for managing pulmonary tuberculosis (PTB), particularly multidrug-resistant tuberculosis. We aimed to evaluate the efficacy of the combination of simultaneous amplification testing (SAT) and reverse dot blot (RDB) for the rapid detection of Mycobacterium tuberculosis (MTB) and drug-resistant mutants in respiratory samples. METHODS: 225 suspected PTB and 32 non-TB pulmonary disease samples were collected. All sputum samples were sent for acid-fast bacilli smear, SAT, culture and drug susceptibility testing (DST) by the BACTEC(TM) MGIT(TM) 960 system...
November 14, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29101404/autoreactive-t-cells-in-immunopathogenesis-of-tb-associated-uveitis
#14
Ravichandra Tagirasa, Shaifaly Parmar, Manas R Barik, Satish Devadas, Soumyava Basu
Purpose: Intraocular inflammation in tuberculosis-associated uveitis (TBU) is usually widespread, and responds unpredictably to treatment. Herein, we analyze the intraocular T-cell response in TBU for its surface phenotype, antigenic specificity, and functional characteristics to explain the above observations. Methods: We isolated T cells from vitreous humor samples of patients with TBU and non-TB uveitis (controls). These were directly stained for surface markers CD4, CD8, CD45RO, CD45RA, CCR7, as well as intracellular cytokines IFN-γ, TNF-α, and IL-17 and analyzed on flow cytometry...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29089034/rapid-diagnosis-of-new-and-relapse-tuberculosis-by-quantification-of-a-circulating-antigen-in-hiv-infected-adults-in-the-greater-houston-metropolitan-area
#15
Jia Fan, Hedong Zhang, Duc T Nguyen, Christopher J Lyon, Charles D Mitchell, Zhen Zhao, Edward A Graviss, Ye Hu
BACKGROUND: HIV-associated immune defects inhibit tuberculosis (TB) diagnosis, promote development of extrapulmonary TB and paucibacillary pulmonary TB cases with atypical radiographic features, and increase TB relapse rates. We therefore assessed the diagnostic performance of a novel assay that directly quantitates serum levels of the Mycobacterium tuberculosis (Mtb) virulence factor 10-kDa culture filtrate protein (CFP-10) to overcome limitations associated with detecting Mtb bacilli in sputum or tissue biopsies...
November 1, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28845558/history-of-pulmonary-tuberculosis-affects-the-severity-and-clinical-outcomes-of-copd
#16
Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Deog Kyeom Kim, Yu Il Kim, Jin Young Oh, Hyoung Kyu Yoon, Kwang-Ha Yoo, Ki Suck Jung
BACKGROUND AND OBJECTIVE: Although an association between pulmonary tuberculosis (TB) and chronic obstructive pulmonary disease (COPD) has been suggested, studies on the effect of TB in COPD patients have not been conducted. We aimed to investigate the severity and clinical outcomes of COPD in patients with and without a history of TB. METHODS: We retrospectively reviewed the data of 1784 patients with COPD in the Korean COPD Subtype Study cohort collected from December 2011 to January 2017 and followed up for 3 years...
January 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28802406/real-time-pcr-followed-by-high-resolution-melting-curve-analysis-a-rapid-and-pragmatic-approach-for-screening-of-multidrug-resistant-extrapulmonary-tuberculosis
#17
Kusum Sharma, Megha Sharma, Shreya Singh, Manish Modi, Aman Sharma, Pallab Ray, Subhash Varma
INTRODUCTION: Multidrug resistance (MDR) in extrapulmonary tuberculosis (EPTB) is a diagnostic challenge in an endemic country like India. Timely detection of MDR-TB can contribute to a better patient outcome. OBJECTIVE: To perform real-time PCR (qPCR) using rpoB, mpb64 and IS6110 gene on a variety of EPTB samples and to compare the performance of different gene targets. All qPCR positive samples were subjected to high resolution melt-curve analysis (HRM analysis) for rpoB and katG gene to evaluate its potential for MDR screening among different sample types...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28798488/analysis-of-factors-influencing-diagnostic-accuracy-of-t-spot-tb-for-active-tuberculosis-in-clinical-practice
#18
Lifan Zhang, Xiaochun Shi, Yueqiu Zhang, Yao Zhang, Feifei Huo, Baotong Zhou, Guohua Deng, Xiaoqing Liu
T-SPOT.TB didn't perform a perfect diagnosis for active tuberculosis (ATB), and some factors may influence the results. We did this study to evaluate possible factors associated with the sensitivity and specificity of T-SPOT.TB, and the diagnostic parameters under varied conditions. Patients with suspected ATB were enrolled prospectively. Influencing factors of the sensitivity and specificity of T-SPOT.TB were evaluated using logistic regression models. Sensitivity, specificity, predictive values (PV), and likelihood ratios (LR) were calculated with consideration of relevant factors...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794178/potential-of-high-affinity-slow-off-rate-modified-aptamer-reagents-for-mycobacterium-tuberculosis-proteins-as-tools-for-infection-models-and-diagnostic-applications
#19
Theresa M Russell, Louis S Green, Taylor Rice, Nicole A Kruh-Garcia, Karen Dobos, Mary A De Groote, Thomas Hraha, David G Sterling, Nebojsa Janjic, Urs A Ochsner
Direct pathogen detection in blood to diagnose active tuberculosis (TB) has been difficult due to low levels of circulating antigens or due to the lack of specific, high-affinity binding reagents and reliable assays with adequate sensitivity. We sought to determine whether slow off-rate modified aptamer (SOMAmer) reagents with subnanomolar affinity for Mycobacterium tuberculosis proteins (antigens 85A, 85B, 85C, GroES, GroEL2, DnaK, CFP10, KAD, CFP2, RplL, and Tpx) could be useful to diagnose tuberculosis. When incorporated into the multiplexed, array-based proteomic SOMAscan assay, limits of detection reached the subpicomolar range in 40% serum...
October 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28794177/discovery-and-validation-of-a-six-marker-serum-protein-signature-for-the-diagnosis-of-active-pulmonary-tuberculosis
#20
Mary A De Groote, David G Sterling, Thomas Hraha, Theresa M Russell, Louis S Green, Kirsten Wall, Stephan Kraemer, Rachel Ostroff, Nebojsa Janjic, Urs A Ochsner
New non-sputum biomarker tests for active tuberculosis (TB) diagnostics are of the highest priority for global TB control. We performed in-depth proteomic analysis using the 4,000-plex SOMAscan assay on 1,470 serum samples from seven countries where TB is endemic. All samples were from patients with symptoms and signs suggestive of active pulmonary TB that were systematically confirmed or ruled out for TB by culture and clinical follow-up. HIV coinfection was present in 34% of samples, and 25% were sputum smear negative...
October 2017: Journal of Clinical Microbiology
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