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https://www.readbyqxmd.com/read/29651163/prospective-comparison-of-qft-git-and-t-spot-tb-assays-for-diagnosis-of-active-tuberculosis
#1
Fengjiao Du, Li Xie, Yonghong Zhang, Fei Gao, Huibin Zhang, Wei Chen, Bingqi Sun, Wei Sha, Yong Fang, Hongyan Jia, Aiying Xing, Boping Du, Li Zheng, Mengqiu Gao, Zongde Zhang
T-SPOT.TB and QuantiFERON-TB Gold In-Tube (QFT-GIT) tests, as two commercial blood assays for diagnosing active tuberculosis (ATB), are not yet fully validated. Especially, there are no reports on comparing the efficacy between the two tests in the same population in China. A multicenter, prospective comparison study was undertaken at four hospitals specializing in pulmonary diseases. A total of 746 suspected pulmonary TB were enrolled and categorized, including 185 confirmed TB, 298 probable TB and 263 non-TB...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29621876/impact-of-pulmonary-tuberculosis-on-the-egfr-mutational-status-and-clinical-outcome-in-patients-with-lung-adenocarcinoma
#2
In Kyoung Hwang, Seung Sook Paik, Seung Hyeun Lee
Purpose: Although it has been suggested that pulmonary tuberculosis (TB) is associated with increased risk of lung cancer, the exact mechanism is not clearly identified. We investigated the effect of pulmonary TB on the epidermal growth factor receptor (EGFR) mutational status and clinical outcome in patients with pulmonary adenocarcinoma. Materials and Methods: We reviewed data of patients diagnosed with pulmonary adenocarcinoma harboring EGFR mutations and treated at our institution from 2008 to 2015...
April 2, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29579086/tuberculosis-during-pregnancy-in-the-united-states-racial-ethnic-disparities-in-pregnancy-complications-and-in-hospital-death
#3
Erika M Dennis, Yun Hao, Mabella Tamambang, Tasha N Roshan, Knubian J Gatlin, Hanane Bghigh, Oladimeji T Ogunyemi, Fatoumata Diallo, Kiara K Spooner, Jason L Salemi, Omonike A Olaleye, Kashif Z Khan, Muktar H Aliyu, Hamisu M Salihu
BACKGROUND: Despite decades of efforts to eliminate tuberculosis (TB) in the United States (US), TB still contributes to adverse ill health, especially among racial/ethnic minorities. According to the Centers for Disease Control and Prevention, in 2016, about 87% of the TB cases reported in the US were among racial and ethnic minorities. The objective of this study is to explore the risks for pregnancy complications and in-hospital death among mothers diagnosed with TB across racial/ethnic groups in the US...
2018: PloS One
https://www.readbyqxmd.com/read/29562934/diagnostic-performance-and-problem-analysis-of-commercial-tuberculosis-antibody-detection-kits-in-china
#4
Xue-Juan Bai, You-Rong Yang, Jian-Qin Liang, Hui-Ru An, Jie Wang, Yan-Bo Ling, Zhong-Yuan Wang, Xue-Qiong Wu
BACKGROUND: The diagnosis of bacterium-negative pulmonary tuberculosis (TB) and extra-pulmonary TB is challenging clinically. The detection of the anti-TB antibody has an important, auxiliary, clinical diagnostic value. Therefore, TB antibody detection kits should be screened and evaluated, and the reagents with the highest sensitivity and specificity should be chosen and used clinically. METHODS: The diagnostic performance of 7 commercially available TB antibody detection kits (kits A, B, C, D, E, F and G) based on the gold immunoassay detection of immunoglobulin (Ig) G or IgM antibodies were simultaneously evaluated and compared in 62 TB cases and 56 non-TB cases in a laboratory...
March 22, 2018: Military Medical Research
https://www.readbyqxmd.com/read/29543810/identification-of-plasma-biomarkers-for-discrimination-between-tuberculosis-infection-disease-and-pulmonary-non-tuberculosis-disease
#5
Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo
We used the Luminex Bead Array Multiplex Immunoassay to measure cytokines, chemokines and growth factors responses to the same antigens used for RD1-based Interferon γ Release Assay (IGRA) test. Seventy-nine individuals, 27 active TB, 32 latent infection subsets, 20 individuals derivative purified protein (PPD) negative (subjects that do not have any indurative cutaneous reaction after 72 hrs of intradermal injection of PPD) and with other pulmonary disease were retrospectively studied. Forty-eight analytes were evaluated by Luminex Assay in plasma obtained from whole blood stimulated cells...
2018: PloS One
https://www.readbyqxmd.com/read/29529901/evaluation-of-risk-factors-for-false-negative-results-with-an-antigen-specific-peripheral-blood-based-quantitative-t-cell-assay-t-spot-%C3%A2-tb-in-the-diagnosis-of-active-tuberculosis-a-large-scale-retrospective-study-in-china
#6
Chi Yang, Shaojun Zhang, Lan Yao, Lin Fan
Objective To investigate the diagnostic efficacy of an interferon-γ release assay, T-SPOT® . TB, for diagnosing active tuberculosis (TB) and to identify risk factors for false-negative results. Methods This retrospective study enrolled consecutive patients with active TB and with non-TB respiratory diseases to evaluate the risk factors for false-negative results when using the T-SPOT® . TB assay for the diagnosis of active TB. Patients with active TB were categorized as having confirmed pulmonary TB, clinically diagnosed pulmonary TB or extrapulmonary TB (EPTB)...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29529307/opportunistic-infections-in-rheumatoid-arthritis-patients-exposed-to-biologic-therapy-results-from-the-british-society-for-rheumatology-biologics-register-for-rheumatoid-arthritis
#7
Andrew I Rutherford, Eunice Patarata, Sujith Subesinghe, Kimme L Hyrich, James B Galloway
Objectives: This analysis set out to estimate the risk of opportunistic infection (OI) among patients with RA by biologic class. Methods: The British Society for Rheumatology Biologics Register for Rheumatoid Arthritis is a prospective observational cohort study established to evaluate safety of biologic therapies. The population included adults commencing biologic therapy for RA. The primary outcome was any serious OI excluding tuberculosis (TB). Event rates were compared across biologic classes using Cox proportional hazards with adjustment for potential confounders identified a priori...
February 26, 2018: Rheumatology
https://www.readbyqxmd.com/read/29505017/household-tuberculosis-contact-investigation-in-a-tuberculosis-prevalent-country-are-the-tuberculin-skin-test-and-interferon-gamma-release-assay-enough-in-elderly-contacts
#8
Jung Seop Eom, Insu Kim, Won-Young Kim, Eun-Jung Jo, Jeongha Mok, Mi-Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee
The high background rates of positive results on the tuberculin skin test (TST) and interferon-gamma release assay (IGRA) sometimes confuse the investigation of tuberculosis (TB) contact in TB-prevalent countries, particularly in elderly contacts. The aim was to investigate the predictive value of TST and IGRA for diagnosing latent TB infection (LTBI) in elderly household contacts in South Korea.In this retrospective study, TST and IGRA results of household contacts of suspected pulmonary TB patients were reviewed according to the index patient's final diagnosis (TB group: culture-confirmed pulmonary TB, non-TB group: pulmonary disease other than TB)...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29490150/tuberculosis-mortality-in-the-united-states-epidemiology-and-prevention-opportunities
#9
Suzanne F Beavers, Lisa Pascopella, Amy L Davidow, Joan M Mangan, Yael R Hirsch-Moverman, Jonathan E Golub, Henry M Blumberg, Risa M Webb, Rachel A Royce, Susan E Buskin, Michael K Leonard, Paul C Weinfurter, Robert W Belknap, Stephen E Hughes, Jon V Warkentin, Sharon F Welbel, Thaddeus L Miller, Saini R Kundipati, Michael Lauzardo, Pennan M Barry, Dolly J Katz, Denise O Garrett, Edward A Graviss, Jennifer M Flood
RATIONALE: More information on risk factors for death from tuberculosis in the United States could help reduce the tuberculosis mortality rate, which has remained steady for over a decade. Objective(s) To identify risk factors for tuberculosis-related death in adults. METHODS: We performed a retrospective study of 1,304 adults with tuberculosis who died before treatment completion and 1,039 frequency-matched controls who completed tuberculosis treatment in 2005-2006 in thirteen states reporting 65% of U...
February 28, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29464970/comparative-evaluation-of-genexpert-mtb-rif-and-multiplex-pcr-targeting-mpb64-and-is6110-for-the-diagnosis-of-pleural-tb
#10
Suman Sharma, Bhawna Dahiya, Vishnubhatla Sreenivas, Netrapal Singh, Ankush Raj, Abhishek Sheoran, Aparna Yadav, Krishna B Gupta, Promod K Mehta
AIM: Diagnosis of pleural TB poses serious challenges due to paucibacillary nature of specimens and there is an urgent need to devise a reliable diagnostic test. METHODS: We compared GeneXpert Mycobacterium tuberculosis/rifampin assay and the multiplex PCR (M-PCR) targeting mpb64 (Rv1980c) and IS6110 in pleural fluids (n = 78) of pleural TB patients and non-TB controls. RESULTS: The sensitivities of 89.6 and 33.3%, and specificities of 96...
February 21, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29395556/outcomes-of-arthroscopic-management-of-trochanteric-bursitis-in-patients-with-femoroacetabular-impingement-a-comparison-of-two-matched-patient-groups
#11
Alexander R Vap, Justin J Mitchell, Karen K Briggs, Shannen C McNamara, Marc J Philippon
PURPOSE: To determine the prevalence of chronic trochanteric bursitis (TB) in patient being treated for femoroacetabular impingement (FAI) and determine the effectiveness of arthroscopic bursectomy and iliotibial band lengthening (AB-ITB-L) at the time of hip arthroscopy for FAI. METHODS: Patients diagnosed with primary FAI and chronic TB were included in the study. Patients were included if they underwent hip arthroscopy with labral repair, femoral and/or acetabular osteoplasty, and AB-ITB-L...
January 27, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29382589/the-prevalence-and-determinants-of-active-tuberculosis-among-diabetes-patients-in-cape-town-south-africa-a-high-hiv-tb-burden-setting
#12
Natacha Berkowitz, Adaeze Okorie, Rene Goliath, Naomi Levitt, Robert J Wilkinson, Tolu Oni
AIMS: Studies addressing the association between diabetes mellitus (DM) and tuberculosis (TB) in sub-Saharan Africa are limited. We assessed the prevalence of active TB among DM patients at a primary care clinic, and identified risk factors for prevalent TB. METHODS: A cross-sectional study was conducted in adult DM patients attending a clinic in Khayelitsha, Cape Town. Participants were screened for active TB (symptom screening and microbiological diagnosis) and HIV...
January 27, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29363640/interferon-gamma-release-assay-is-not-appropriate-for-the-diagnosis-of-active-tuberculosis-in-high-burden-tuberculosis-settings-a-retrospective-multicenter-investigation
#13
Wan-Li Kang, Gui-Rong Wang, Mei-Ying Wu, Kun-Yun Yang, A Er-Tai, Shu-Cai Wu, Shu-Jun Geng, Zhi-Hui Li, Ming-Wu Li, Liang Li, Shen-Jie Tang
BACKGROUND: Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis, but the results from different high TB-endemic countries are different. The aim of this study was to investigate the value of IGRA in the diagnosis of active pulmonary TB (PTB) in China. METHODS: We conducted a large-scale retrospective multicenter investigation to further evaluate the role of IGRA in the diagnosis of active PTB in high TB-epidemic populations and the factors affecting the performance of the assay...
February 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29318113/application-values-of-t-spot-tb-in-clinical-rapid-diagnosis-of-tuberculosis
#14
Feng Zhu, Qinfang Ou, Jian Zheng
Background: This paper aims to explore the application value of tuberculosis-specific enzyme-linked immunospot assay (T-SPOT.TB) in the diagnosis of tuberculosis. Methods: Fifty one patients with tuberculosis (TB) admitted to Wuxi No.5 People's Hospital, Wuxi, China from June 2015 to June 2017 were selected as the TB group, and 40 patients without tuberculosis admitted in the same period were randomly selected as the non-TB group. Patients in the two groups received T-SPOT...
January 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29297451/cxcr3-ligands-in-pleural-fluid-as-markers-for-the-diagnosis-of-tuberculous-pleural-effusion
#15
W Chung, Y Jung, K Lee, J Park, S Sheen, K Park
SETTING: A tertiary care academic medical centre. OBJECTIVE: To evaluate the clinical usefulness of C-X-C motif chemokine receptor 3 (CXCR3) ligands in tuberculous pleural effusion (TPE). DESIGN: We recruited 336 patients with pleural effusion due to various causes. Concentrations of interferon-gamma (IFN-γ) and the CXCR3 ligands CXCL9 and CXCL11 were determined using enzyme immunoassays; adenosine deaminase (ADA) activity was measured in pleural fluid and serum...
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29237757/urine-lipoarabinomannan-glycan-in-hiv-negative-patients-with-pulmonary-tuberculosis-correlates-with-disease-severity
#16
Luisa Paris, Ruben Magni, Fatima Zaidi, Robyn Araujo, Neal Saini, Michael Harpole, Jorge Coronel, Daniela E Kirwan, Hannah Steinberg, Robert H Gilman, Emanuel F Petricoin, Roberto Nisini, Alessandra Luchini, Lance Liotta
An accurate urine test for pulmonary tuberculosis (TB), affecting 9.6 million patients worldwide, is critically needed for surveillance and treatment management. Past attempts failed to reliably detect the mycobacterial glycan antigen lipoarabinomannan (LAM), a marker of active TB, in HIV-negative, pulmonary TB-infected patients' urine (85% of 9.6 million patients). We apply a copper complex dye within a hydrogel nanocage that captures LAM with very high affinity, displacing interfering urine proteins. The technology was applied to study pretreatment urine from 48 Peruvian patients, all negative for HIV, with microbiologically confirmed active pulmonary TB...
December 13, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29226173/long-term-outcome-of-antiretroviral-treatment-in-patients-with-and-without-concomitant-tuberculosis-receiving-health-center-based-care-results-from-a-prospective-cohort-study
#17
Anton Reepalu, Taye Tolera Balcha, Erik Sturegård, Patrik Medstrand, Per Björkman
Background: In order to increase treatment coverage, antiretroviral treatment (ART) is provided through primary health care in low-income high-burden countries, where tuberculosis (TB) co-infection is common. We investigated the long-term outcome of health center-based ART, with regard to concomitant TB. Methods: ART-naïve adults were included in a prospective cohort at Ethiopian health centers and followed for up to 4 years after starting ART. All participants were investigated for active TB at inclusion...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29216851/what-does-igra-testing-add-to-the-diagnosis-of-ocular-tuberculosis-a-bayesian-latent-class-analysis
#18
Rupesh Agrawal, Robert Grant, Bhaskar Gupta, Dinesh Visva Gunasekeran, Julio J Gonzalez-Lopez, Peter K F Addison, Mark Westcott, Carlos E Pavesio
BACKGROUND: To evaluate the contribution made to the diagnostic work-up for patients with suspected ocular tuberculosis (TB) by QuantiFERON-TB Gold In-Tube (QFT) tests using latent class analysis model. METHODS: A single centre retrospective cohort study. A Bayesian latent class model was constructed on the basis of demographics, phenotypes and test results from patients attending a tertiary referral center in the UK. This estimated the probability of ocular TB for each patient in two versions, first with and then without QFT...
December 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29179784/underweight-increases-the-risk-of-early-death-in-tuberculosis-patients
#19
Yung-Feng Yen, Fu-I Tung, Bo-Lung Ho, Yun-Ju Lai
Evidence regarding the association between BMI and mortality in tuberculosis (TB) patients is limited and inconsistent. We investigated the impact of BMI on TB-specific and non-TB-specific mortality with respect to different timing of death. All Taiwanese adults with TB in Taipei were included in a retrospective cohort study in 2012-2014. Multinomial Cox proportional hazards regression was used to evaluate the associations between BMI, cause-specific mortality and timing of death. Of 2410 eligible patients, 86·0 % (2061) were successfully treated, and TB-specific and non-TB-specific mortality occurred for 2·2 % (54) and 13·9 % (335), respectively...
December 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29176894/horizontal-acquisition-of-a-hypoxia-responsive-molybdenum-cofactor-biosynthesis-pathway-contributed-to-mycobacterium-tuberculosis-pathoadaptation
#20
Florence Levillain, Yannick Poquet, Ludovic Mallet, Serge Mazères, Michael Marceau, Roland Brosch, Franz-Christoph Bange, Philip Supply, Axel Magalon, Olivier Neyrolles
The unique ability of the tuberculosis (TB) bacillus, Mycobacterium tuberculosis, to persist for long periods of time in lung hypoxic lesions chiefly contributes to the global burden of latent TB. We and others previously reported that the M. tuberculosis ancestor underwent massive episodes of horizontal gene transfer (HGT), mostly from environmental species. Here, we sought to explore whether such ancient HGT played a part in M. tuberculosis evolution towards pathogenicity. We were interested by a HGT-acquired M...
November 2017: PLoS Pathogens
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