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https://www.readbyqxmd.com/read/28086779/the-effect-of-electrical-conductivity-of-myocardium-on-cardiac-pumping-efficacy-a-computational-study
#1
Ana Rahma Yuniarti, Ki Moo Lim
BACKGROUND AND AIMS: The existence of non-excitable cells in the myocardium leads to the increasing conduction non-uniformity and decreasing myocardial electrical conductivity. Slowed myocardial conduction velocity (MCV) believed to enhance the probability of cardiac arryhthmia and alter the cardiac mechanical pumping efficacy, even in sinus rhythm. Though several studies on the correlation between MCV and cardiac electrical instabilities exist, there has been no study concerning correlation or causality between MCV and cardiac mechanical pumping efficacy, due to the limitation in clinical methods to document and evaluate cardiac mechanical responses directly...
January 10, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28076389/a-computational-study-on-the-relation-between-resting-heart-rate-and-atrial-fibrillation-hemodynamics-under-exercise
#2
Matteo Anselmino, Stefania Scarsoglio, Andrea Saglietto, Fiorenzo Gaita, Luca Ridolfi
AIMS: Clinical data indicating a heart rate (HR) target during rate control therapy for permanent atrial fibrillation (AF) and assessing its eventual relationship with reduced exercise tolerance are lacking. The present study aims at investigating the impact of resting HR on the hemodynamic response to exercise in permanent AF patients by means of a computational cardiovascular model. METHODS: The AF lumped-parameter model was run to simulate resting (1 Metabolic Equivalent of Task-MET) and various exercise conditions (4 METs: brisk walking; 6 METs: skiing; 8 METs: running), considering different resting HR (70 bpm for the slower resting HR-SHR-simulations, and 100 bpm for the higher resting HR-HHR-simulations)...
2017: PloS One
https://www.readbyqxmd.com/read/28065455/spatial-curvilinear-path-following-control-of-underactuated-auv-with-multiple-uncertainties
#3
Jianming Miao, Shaoping Wang, Zhiping Zhao, Yuan Li, Mileta M Tomovic
This paper ̇α investigates the problem of spatial curvilinear path following control of underactuated autonomous underwater vehicles (AUVs) with multiple uncertainties. Firstly, in order to design the appropriate controller, path following error dynamics model is constructed in a moving Serret-Frenet frame, and the five degrees of freedom (DOFs) dynamic model with multiple uncertainties is established. Secondly, the proposed control law is separated into kinematic controller and dynamic controller via back-stepping technique...
January 5, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28055998/-hypertensive-crisis-urgency-and-hypertensive-emergency
#4
Javier Sobrino Martínez, Mónica Doménech Feria-Carot, Alberto Morales Salinas, Antonia Coca Payeras
Hypertensive crises lumped several clinical situations with different seriousness and prognosis. The differences between hypertensive urgency and hypertensive emergency depends on if this situation involves a vital risk for the patient. This risk is defined more by the severity of the organ damage than for the higher values of blood pressure. The hypertensive urgency not involves an immediately risk for the patient, for these reason, the treatment can be completed after discharged. Otherwise, the hypertensive emergency is a critical clinical condition that requires hospital assistance...
November 18, 2016: Medwave
https://www.readbyqxmd.com/read/28053910/lymphocytoma-cutis-diagnostic-enigma-for-the-maxillofacial-surgeon
#5
Tejraj P Kale, Arjun Gurmeet Singh, Pushpak Shah
Cutaneous lymphoid hyperplasia (CLH) is a cutaneous pseudolymphoma with a worldwide distribution, equally affecting all races and ethnic groups. Due to its vast array of characteristics, it is most often missed in the differential diagnosis of firm to soft lumps on the head and neck. A systematic approach to the workup and diagnosis along with treatment of such lesions is discussed in this article. A 20-year-old Asian Indian female presented to our Oral and Maxillofacial unit with a lump on the left side of her forehead for 1 month...
December 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28051893/shame-in-medical-education-a-randomized-study-of-the-acquisition-of-intimate-examination-skills-and-its-effect-on-subsequent-performance
#6
Wolf E Hautz, Therese Schröder, Katja A Dannenberg, Maren März, Henrike Hölzer, Olaf Ahlers, Anke Thomas
THEORY: Although medical students are exposed to a variety of emotions, the impact of emotions on learning has received little attention so far. Shame-provoking intimate examinations are among the most memorable events for students. Their emotions, however, are rarely addressed during training, potentially leading to withdrawal and avoidance and, consequently, performance deficits. However, emotions of negative valance such as shame may be particularly valuable for learning, as they might prompt mental rehearsal...
January 4, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28045268/reconstitution-properties-of-sucrose-and-maltodextrins
#7
Julien Dupas, Vincent Girard, Laurent Forny
Carbohydrates such as sucrose and maltodextrins are commonly used in dehydrated food beverages. Yet, these ingredients may have in some cases negative impact on reconstitution performance (e.g. lumps formation) compromising key consumer's expectations. In this study, we propose to discuss the performance of carbohydrates with regards to major physical steps of reconstitution (wetting, capillarity, dispersion, dissolution). We show how particle size and water temperature drive kinetics of dissolution of crystalline sucrose and propose descriptive equations...
January 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28042915/haplotyping-rad-loci-an-efficient-method-to-filter-paralogs-and-account-for-physical-linkage
#8
Stuart C Willis, Christopher M Hollenbeck, Jonathan B Puritz, John R Gold, David S Portnoy
Next-generation sequencing of reduced-representation genomic libraries provides a powerful methodology for genotyping thousands of single nucleotide polymorphisms (SNPs) among individuals of non-model species. Utilizing genotype data in the absence of a reference genome, however, presents a number of challenges. One major challenge is the tradeoff between splitting alleles at a single locus into separate clusters (loci), creating inflated homozygosity, and lumping multiple loci into a single contig (locus), creating artifacts and inflated heterozygosity...
January 2, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28040031/near-field-acoustic-holography-measurements-of-carbon-nanotube-thin-film-speakers
#9
Mahsa Asgarisabet, Andrew R Barnard, Troy M Bouman
Carbon nanotube (CNT) thin film speakers produce sound with the thermoacoustic effect. Better understanding of the physical acoustic properties of these speakers will drive future design improvements. Measuring acoustic properties at the surface of the CNT thin film is difficult because the films, themselves, do not vibrate, are fragile and have a high surface temperature. In order to measure the surface particle velocity and sound pressure level (SPL), near field acoustic holography (NAH) has been used by employing probe microphones...
December 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28040003/solving-transient-acoustic-boundary-value-problems-with-equivalent-sources-using-a-lumped-parameter-approach
#10
John B Fahnline
An equivalent source method is developed for solving transient acoustic boundary value problems. The method assumes the boundary surface is discretized in terms of triangular or quadrilateral elements and that the solution is represented using the acoustic fields of discrete sources placed at the element centers. Also, the boundary condition is assumed to be specified for the normal component of the surface velocity as a function of time, and the source amplitudes are determined to match the known elemental volume velocity vector at a series of discrete time steps...
December 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28038771/superior-performance-of-continuous-over-pulsatile-flow-ventricular-assist-devices-in-the-single-ventricle-circulation-a-computational-study
#11
Tyler Schmidt, David Rosenthal, Olaf Reinhartz, Kirk Riemer, Fei He, Tain-Yen Hsia, Alison Marsden, Ethan Kung
This study compares the physiological responses of systemic-to-pulmonary shunted single ventricle patients to pulsatile and continuous flow ventricular assist devices (VADs). Performance differences between pulsatile and continuous flow VADs have been clinically observed, but the underlying mechanism remains poorly understood. Six systemic-to-pulmonary shunted single ventricle patients (mean BSA=0.30m(2)) were computationally simulated using a lumped-parameter network tuned to match patient specific clinical data...
December 20, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28034624/determinants-of-denervation-independent-depletion-of-putamen-dopamine-in-parkinson-s-disease-and-multiple-system-atrophy
#12
David S Goldstein, Patti Sullivan, Courtney Holmes, Deborah C Mash, Irwin J Kopin, Yehonatan Sharabi
BACKGROUND: Severe putamen dopamine depletion characterizes Parkinson's disease (PD) and multiple system atrophy (MSA). The extent of the depletion is greater than can be accounted for by loss of nigrostriatal dopaminergic terminals alone. We used putamen tissue levels and ratios of cysteinyl and parent catechols to explore possible denervation-independent abnormalities of dopamine synthesis and fate in PD and MSA. 5-S-Cysteinyldopa (Cys-DOPA) is produced from spontaneous oxidation of DOPA and 5-S-cysteinyldopamine (Cys-DA) from spontaneous oxidation of DA...
December 15, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28033499/lumped-element-modeling-of-air-coupled-capacitive-micromachined-ultrasonic-transducers-with-annular-cell-geometry
#13
Shuai Na, Lawrence L P Wong, Albert I H Chen, Zhenhao Li, Mirek Macecek, John T W Yeow
Air-coupled capacitive micromachined ultrasonic transducers (CMUTs) based on annular cell geometry have recently been reported. Finite element analysis and experimental studies have demonstrated their significant improvement in transmit efficiency compared with the conventional circular-cell CMUTs. Extending the previous work, this paper proposed a lumped element model of annular-cell CMUTs. Explicit expressions of the resonance frequency, modal vector, and static displacement of a clamped annular plate under uniform pressure were first derived based on the plate theory and curve fitting method...
November 23, 2016: Ultrasonics
https://www.readbyqxmd.com/read/28030581/oncoplastic-surgery-for-upper-upper-inner-quadrant-breast-cancer
#14
Joseph Lin, Dar-Ren Chen, Yu-Fen Wang, Hung-Wen Lai
Tumors located in the upper/upper inner quadrant of the breast warrant more attention. A small lesion relative to the size of breast in this location may be resolved by performing a level I oncoplastic technique. However, a wide excision may significantly reduce the overall quality of the breast shape by distorting the visible breast line. From June 2012 to April 2015, 36 patients with breast cancer located in the upper/upper inner quadrant underwent breast-conservation surgery with matrix rotation mammoplasty...
2016: PloS One
https://www.readbyqxmd.com/read/28029613/a-mems-condenser-microphone-based-intracochlear-acoustic-receiver
#15
Flurin Pfiffner, Lukas Prochazka, Dominik Peus, Ivo Dobrev, Adrian Dalbert, Jae Hoon Sim, Rahel Kesterke, Joris Walraevens, Francesca Paris, Christof Roosli, Dominik Obrist, A M Huber
GOAL: Intracochlear sound pressure (ICSP) measurements are limited by the small dimensions of the human inner ear and the requirements imposed by the liquid medium. A robust intracochlear acoustic receiver (ICAR) for repeated use with a simple data acquisition system that provides the required high sensitivity and small dimensions does not yet exist. The work described in this report aims to fill this gap and presents a new MEMS condenser microphone (CMIC) based ICAR concept suitable for ICSP measurements in human temporal bones...
December 16, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28029417/paying-for-volume-british-columbia-s-experiment-with-funding-hospitals-based-on-activity
#16
Jason M Sutherland, Guiping Liu, R Trafford Crump, Michael Law
INTRODUCTION: For decades, Canadian hospitals have been funded using global budgets, a lump sum for providing care irrespective of the volume or mix of patients. In 2010, British Columbia (BC) introduced a controversial, but limited, form of activity-based funding (ABF) for hospitals. This study uses a quasi-experimental design to evaluate the impact of the introduction of ABF funding in the province. METHODS: Our analysis used the population of patient-level acute hospitalization and day surgery discharge summaries from BC's acute hospitals from April 1, 2008 to March 31, 2013...
September 24, 2016: Health Policy
https://www.readbyqxmd.com/read/28028334/liquid-based-versus-conventional-cytology-in-solid-pediatric-neoplasm-comparison-of-their-diagnostic-and-morphological-spectra
#17
Preeti Agarwal, Sunita Yadav, Archana Kumar, Madhu M Goel
BACKGROUND: Conventional cytology (CC) is a well-established and effective methodology for the evaluation of pediatric tumors. Liquid-based cytology (LBC) is a better technique of smear preparation and is at present the standard protocol in cervical cytology samples. AIMS: In the present study, we analyzed both smear preparatory techniques in fine-needle aspiration (FNA) samples from solid pediatric neoplasms in terms of adequacy and efficacy with objectives to study the changes in background and morphology of tumor cells in LBC smears...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/28025826/concurrent-use-of-continuous-and-pulsatile-flow-ventricular-assist-device-on-a-fontan-patient-a-simulation-study
#18
Arianna Di Molfetta, Gianfranco Ferrari, Roberta Iacobelli, Sergio Filippelli, Antonio Amodeo
The aim of this work is to develop and test a lumped parameter model of the cardiovascular system to simulate the concurrent use of pulsatile (PVAD) and continuous flow (CVAD) ventricular assist device (VAD) on Fontan patients. Echocardiographic and hemodynamic data of five Fontan patients were retrospectively collected and used to simulate the patients' baseline hemodynamics. Then, for each patient, the following assistance modality was simulated for the cavopulmonary and the single ventricle (SV): (a) CVAD for cavopulmonary assistance (RCF) and PVAD assisting the SV (LCF) (RPF + LCF), (b) CVAD assisting SV and PVAD for cavopulmonary assistance (LPF + RCF)...
December 26, 2016: Artificial Organs
https://www.readbyqxmd.com/read/28007566/by-how-much-do-we-underestimate-species-diversity-of-liverworts-using-morphological-evidence-an-example-from-australasian-plagiochila-plagiochilaceae-jungermanniopsida
#19
Matt A M Renner, Margaret M Heslewood, Simon D F Patzak, Alfons Schäfer-Verwimp, Jochen Heinrichs
As a framework for revisionary study of the leafy liverwort Plagiochila in Australia, two methods for species delimitation on molecular sequence data, General Mixed Yule Coalescence model (GMYC) and Automatic Barcode Gap Discovery (ABGD) were applied to a dataset including 265 individuals from Australia, New Zealand, and the Pacific. Groups returned by GMYC and ABGD were incongruent in some lineages, and ABGD tended to lump groups. This may reflect underlying heterogeneity in the history of diversification within different lineages of Plagiochila...
December 19, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28006719/male-breast-cancer-modified-radical-mastectomy-or-breast-conservation-surgery-a-case-report-and-review-of-the-literature
#20
Gabriele Giunta, Matteo Rossi, Francesca Toia, Gaetana Rinaldi, Adriana Cordova
INTRODUCTION: Male breast cancer (MBC) is a rare disease that accounts for <1% of breast cancer cases. The most common treatment is modified radical mastectomy (MRM). Recently, breast conservative surgery (BCS) is getting popular for MBC treatment. We report a case and reviewed the literature to investigate whether emerging BCS can be considered as an alternative of a more radical surgery. PRESENTATION OF CASE: A 46 y.o. patient, presented with a painless left breast lump over a period of six months...
November 19, 2016: International Journal of Surgery Case Reports
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