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Yuhao Qiang, Jia Liu, E Du
Dielectrophoresis in microfluidics provides a useful tool to test biomechanics of living cells, regardless of surface charges on cell membranes. We have designed an experimental method to characterize the nonlinear viscoelastic behaviors of single cells using dielectrophoresis in a microfluidic channel. This method uses radio frequency, low voltage excitations through interdigitated microelectrodes, allowing probing multiple cells simultaneously with controllable load levels. Dielectrophoretic force was calibrated using a triaxial ellipsoid model...
2018: Micromachines
Saurabh Gandhi, Eham Arora, Ajay Bhandarwar, Arun Patil, Amol Wagh, Shubham Gupta
Bezoars are intra-luminal concretions of ingested material which accumulate within the bowel. They are termed pharmacobezoars when the constituent material is drugs. We report a 64-year-old female with abdominal pain and obstipation for 3 days. Patient had completed anti-tuberculous combination therapy for suspected abdominal tuberculosis 25 years ago. She exhibited features of shock with a right iliac fossa lump. Abdominal X-ray displayed multiple air-fluid levels with densely cluttered radio-opacities in the right lower quadrant...
April 21, 2018: Clinical Journal of Gastroenterology
Arani Halder, Jennifer Sommerville, Mitesh Gandhi
Lymphoepithelial carcinoma (LEC) is a rare malignancy of the salivary gland arising from the parotid in 80% of cases. LEC is indistinguishable histologically from more common non-keratinising undifferentiated nasopharyngeal carcinoma (NPC). Up to 40% of patients with primary LEC present with a cervical metastasis and histological assessment of the primary lesion or nodal metastasis may be reported as NPC. The absence of a nasopharyngeal lesion on imaging and endoscopic assessment together with a parotid mass strengthens the case for a LEC...
April 20, 2018: Journal of Medical Imaging and Radiation Oncology
Gaurav Vaidya, Denis Lepage, Robert Guralnick
While studies of taxonomy usually focus on species description, there is also a taxonomic correction process that retests and updates existing species circumscriptions on the basis of new evidence. These corrections may themselves be subsequently retested and recorrected. We studied this correction process by using the Check-List of North and Middle American Birds, a well-known taxonomic checklist that spans 130 years. We identified 142 lumps and 95 splits across sixty-three versions of the Check-List and found that while lumping rates have markedly decreased since the 1970s, splitting rates are accelerating...
2018: PloS One
Xiaobin Zeng, Lifeng Xie, Zhiqiang Qiu, Kuo Sun
RATIONALE: Popliteal cyst developing in the sheath of a peripheral nerve or joint capsule may cause compression neuropathy. Although popliteal cyst is very common lesion, it seldom causes serious complications. Common peroneal nerve compression is rarely caused by an extraneural popliteal cyst. PATIENT CONCERNS: We presented the case of a 52-year-old female with common peroneal nerve compression caused by an extraneural popliteal cyst. DIAGNOSES: Electromyography showed the damage of common peroneal nerve...
April 2018: Medicine (Baltimore)
Wenguang Zhang, Jiaqi Tang, Zhengwei Li, Yakun Ma
In order to solve the problem of the short lifespan of the neural electrode caused by micro motion, this study designed a novel neural electrode based on lumped compliance compliant mechanism to control different modes of micro-motion in a more effective way. According to the mathematical modeling of the novel neural electrode, the equivalent bending stiffness and equivalent tensile (compression) stiffness were calculated. The results of the finite element analysis based on the mathematical modeling revealed that the novel neural electrode showed excellent micro-motion-attenuation capability...
April 18, 2018: Medical & Biological Engineering & Computing
Geok Hoon Lim, Samantha Piao Xue Tay, Mihir Gudi
An elderly woman, with no clinically palpable breast lump, presented with an initially benign-appearing lesion on ultrasound. She was followed up to reveal the natural history of luminal A breast cancer.
April 17, 2018: BMJ Case Reports
Rafael R de la Haba, Paulina Corral, Cristina Sánchez-Porro, Carmen Infante-Domínguez, Andrea M Makkay, Mohammad A Amoozegar, Antonio Ventosa, R Thane Papke
To gain a better understanding of how divergence occurs, and how taxonomy can benefit from studying natural populations, we isolated and examined 25 closely related Halorubrum strains obtained from different hypersaline communities and compared them to validly named species and other reference strains using five taxonomic study approaches: phylogenetic analysis using the 16S rRNA gene and multilocus sequencing analysis (MLSA), polar lipid profiles (PLP), average nucleotide identity (ANI) and DNA-DNA hybridization (DDH)...
2018: Frontiers in Microbiology
Hitomi Kubota, Keita Adachi, Shuhei Suzuki, Shigeru Fujisaki, Yukiko Hara, Katsuhisa Enomoto, Ryouichi Tomita, Tomohiro Hirano, Kenichi Sakurai
We report a case of a simultaneous and ipsilateral multiple breast carcinoma.The patient was 35-year-old woman.She was noticed a breast lump on her right breast, and visited our hospital.Mammography showed a tumor accompanied by spiculation on her right breast.Ultrasonography revealed 2 tumors with irregular margins, 23mm in diameter and 12mm in diameter, and were observed on C area of her right breast.The continuity of the 2 tumors was not clear.Core needle biopsies for each breast tumors led to a diagnosis...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Parul Tanwar, Jatin S Gandhi, Anila Sharma, Manoj Gupta, Partha S Choudhary
Breast metastases are a relatively rare condition and account for approximately 0.5-2% of all breast tumors. Recognition of metastatic tumors in the breast is important because it would prevent unnecessary mutilating surgery and would lead to appropriate treatment of the primary tumor. Breast metastases from medullary thyroid cancer (MTC) are very rare with only 21 reported cases in the literature. Some MTCs mimic primary invasive lobular carcinoma of the breast histopathologically and radiologically, making the distinction between the two diagnostically challenging...
April 2018: Journal of Cytology
Yasmeen Khatib, Vinita Pandey, Archana L Khade, Rahul Pandey
A breast mass in a postmenopausal age woman is treated with a high index of clinical suspicion for malignancy. Myofibroblastoma (MFB) of the breast is a very rare benign stromal tumor, predominantly occurring in menopausal women and older men. Owing to its rarity, nonspecific radiology, cytomorphology, and many variants, it can be confused with other malignant and benign breast lesions and hence can be a source of diagnostic pitfall. We present a case of an MFB of the breast in a 55-year-old female, which was detected on a routine screening mammography...
January 2018: Journal of Mid-life Health
Debasis Gochhait, Priyadarshini Dehuri, Sandyya Umamahesweran, Rohan Kamat
Male breast can show almost all pathological entities described in female breast. Inflammatory conditions of the breast in male are not common; however, occasionally, it can be encountered in the form of an abscess. Clinically, gynecomastia always presents as a symmetric unilateral or bilateral lump in the retroareolar region, and any irregular asymmetric lump raises a possibility of malignancy. Radiology should be used as a part of the triple assessment protocol for breast lump along with fine-needle aspiration cytology for definite diagnosis and proper management...
January 2018: Journal of Mid-life Health
Bettina Debû, Clecio De Oliveira Godeiro, Jarbas Correa Lino, Elena Moro
PURPOSE OF REVIEW: Postural instability and gait difficulties inexorably worsen with Parkinson's disease (PD) progression and become treatment resistant, with a severe impact on autonomy and quality of life. We review the main characteristics of balance instability, gait disabilities, and static postural alterations in advanced PD, and the available treatment strategies. RECENT FINDINGS: It remains very difficult to satisfactorily alleviate gait and postural disturbances in advanced PD...
April 6, 2018: Current Neurology and Neuroscience Reports
Deli Xiao, Yue Jiang, Yanping Bi
This review (with 154 refs.) describes the current status of using molecularly imprinted polymers in the extraction and quantitation of illicit drugs and additives. The review starts with an introduction into some synthesis methods (lump MIPs, spherical MIPs, surface imprinting) of MIPs using illicit drugs and additives as templates. The next section covers applications, with subsections on the detection of illegal additives in food, of doping in sports, and of illicit addictive drugs. A particular focus is directed towards current limitations and challenges, on the optimization of methods for preparation of MIPs, their applicability to aqueous samples, the leakage of template molecules, and the identification of the best balance between adsorption capacity and selectivity factor...
April 4, 2018: Mikrochimica Acta
GianLuca Quaglio, Damiano Pizzol, Anna Bortolani, Fabio Manenti, Petros Isaakidis, Giovanni Putoto, Piero L Olliaro
SETTING: Breast tuberculosis in male is a rarely reported and poorly described condition. OBJECTIVE: To quantify the number of breast tuberculosis in men, to describe clinical presentation and to present the diagnostic and therapeutic procedures applied. DESIGN: A systematic review of the literature including reports published in English, Spanish and French until December 2017. RESULTS: The search yielded 26 cases of male breast tuberculosis, median age 56...
2018: PloS One
Jeong Hyun Ha, Euicheol Jeong, Hudson Lazaro
Formation of an ideally-shaped tragus remains one of the most challenging issues during staged tragus reconstruction in microtia patients. The authors describe a new method used to treat a unique case of concha-type microtia in which the 10-year-old male patient had only a portion of pre-existing cartilage at the tragus site. An anomalous skin lump was also present. During the initial stages of the reconstruction, the two-stage Nagata method was used for surgical correction of the microtia. An autologous rib cartilage graft was used to form the ear framework...
March 2018: Archives of Craniofacial Surgery
Hira Abdul Razzak, Alya Harbi, Wael Shelpai, xAhmadxx Qawas
Cancer is recognized to be a major healthcare problem globally. Cancer is a disease that mainly occurs when alterations in a normal cell group within the body leads to uncontrolled growth, mainly causing a lump referred to as a tumor. The aim of this study is to systematically review and extract studies reporting the risk factors of cancer in UAE between 2007 and 2016. A systematic literature search was performed by using "PubMed, Scopus databases, Science direct, and local journals" and appropriate key terms to retrieve studies carried out in United Arab Emirates with regards to risk factors of the cancer...
January 2018: Gulf Journal of Oncology
Amr Baz
A class of active acoustic diodes and metamaterials is developed to control the flow and distribution of acoustic energy in acoustic cavities and systems. Such development departs radically from the currently available approaches where the non-reciprocities are generated by hard-wired designs, favoring one transmission direction which is dictated by the arrangement of the hardware and hence it cannot be reversed, or without the presentation of rigorous control theory analysis. The proposed active nonreciprocal acoustic metamaterial (ANAM) cell consists of a one-dimensional acoustic cavity provided with active flexible boundaries...
March 2018: Journal of the Acoustical Society of America
Dieanira Erudaitius, Jacqueline Mantooth, Andrew Huang, Jesse Soliman, Claire Doskey, Garry R Buettner, Victor G J Rodgers
The high extracellular hydrogen peroxide (H2 O2 ) concentrations generated during pharmacological ascorbate (P-AscH- ) therapy has been shown to exhibit a high flux into susceptible cancer cells leading to a decrease in clonogenic survival. It is hypothesized that the intracellular H2 O2 concentration for susceptibility is independent of cell type and that the variation observed in dosing is associated with differences in the cell-specific overall steady-state intracellular H2 O2 concentration values. The steady-state variation in intracellular H2 O2 concentration is coupled to a number of cellular specific transport and reaction factors including catalase activity and membrane permeability...
March 27, 2018: Free Radical Biology & Medicine
Ying-Chun Zhu, Xue-Wen Jia, Zhe-Yang Wang, Cui Wang, Zhan-Ping Jin
OBJECTIVE: To compare technique and clinical effect of arthroscopic and conventional sectional therapy for the treatment of ischial tuberosity cyst. METHODS: From May 2014 and September 2016, 49 patients with symptomatic ischial tuberosity cyst were randomized divided into arthroscopic group and conventional section group by envelope method. There were 24 patients in arthroscopic group, including 16 males and 8 females aged from 42 to 81years old with an average age of (64...
March 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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