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https://www.readbyqxmd.com/read/28214467/paxillin-a-crossroad-in-pathological-cell-migration
#1
REVIEW
Ana María López-Colomé, Irene Lee-Rivera, Regina Benavides-Hidalgo, Edith López
Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell movement and migration, when phosphorylated on specific Tyr and Ser residues. Upon integrin engagement with extracellular matrix, paxillin is phosphorylated at Tyr31, Tyr118, Ser188, and Ser190, activating numerous signaling cascades which promote cell migration, indicating that the regulation of adhesion dynamics is under the control of a complex display of signaling mechanisms...
February 18, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28201934/feeding-value-of-field-beans-vicia-faba-l-var-minor-with-and-without-enzyme-containing-tannase-pectinase-and-xylanase-activities-for-broilers
#2
Jalil Mahmwd Abdulla, Stephen Paul Rose, Alexander Mackay Mackenzie, Vasil Radoslavov Pirgozliev
Effects of field beans with various tannin content and exogenous enzyme mixture containing tannase, pectinase and xylanase activities on N-corrected dietary apparent metabolisable energy (AMEn), coefficients of dry matter (DMR) and nitrogen retention (NR), fat digestibility, gastrointestinal tract (GIT) development, jejunal villus morphometry, ileal digesta viscosity and sialic acid were examined. Birds' growth performance and energy conversion ratio (ECR) were also measured. Birds were fed one of eight mash diets...
April 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28185291/review-article-pathogenesis-and-clinical-manifestations-of-gastrointestinal-involvement-in-systemic-sclerosis
#3
REVIEW
S Kumar, J Singh, S Rattan, A J DiMarino, S Cohen, S A Jimenez
BACKGROUND: Gastrointestinal tract (GIT) involvement is a common cause of debilitating symptoms in patients with systemic sclerosis (SSc). There are no disease modifying therapies for this condition and the treatment remains symptomatic, largely owing to the lack of a clear understanding of its pathogenesis. AIMS: To investigate novel aspects of the pathogenesis of gastrointestinal involvement in SSc. To summarise existing knowledge regarding the cardinal clinical gastrointestinal manifestations of SSc and its pathogenesis, emphasising recent investigations that may be valuable in identifying potentially novel therapeutic targets...
February 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28173798/spasmogenic-and-spasmolytic-activity-of-rind-of-punica-granatum-linn
#4
Niaz Ali, Ayesha Jamil, Syed Wadood Ali Shah, Ismail Shah, Ghayour Ahmed
BACKGROUND: Rind of Punica granatum is traditionally used in treatment of abdominal cramps and various GIT disorders. So far spasmolytic activity of rind of Punica granatum has been reported using in vitro model. However, its mode of action is not explored yet. Therefore, the current work describes the possible mode of action for spasmolytic activity of methanolic extract of rind of Punica granatum (Pg. Cr). Acute toxicity study is also performed to determine its safe dose range. METHODS: Rind of Punica granatum was subjected to shade drying...
February 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28164000/spinal-dural-arteriovenous-fistula-and-cecal-arteriovenous-malformation-in-a-boy
#5
Vimlesh Soni, Pankaj C Vaidya, Jitendra Kumar Sahu, Mukesh Yadav, Pratibha Singhi
Concurrent spinal dural arteriovenous fistula (AVF) and cecal arteriovenous malformation (AVM) are very rare. A 6-year old boy presented with lower limb paresis after trauma. On imaging work-up spinal dural AVF was found. It was managed with endovascular glue embolization. After two years, the boy presented with severe anemia and occult gastrointestinal tract (GIT) bleed. Cecal AVM was diagnosed and managed with embolization.
January 2017: APSP Journal of Case Reports
https://www.readbyqxmd.com/read/28156160/orally-delivered-polycurcumin-responsive-to-bacterial-reduction-for-targeted-therapy-of-inflammatory-bowel-disease
#6
Hongzhi Qiao, Dong Fang, Jing Chen, Yuan Sun, Chen Kang, Liuqing Di, Junsong Li, Zhipeng Chen, Jun Chen, Yahan Gao
Inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis is a chronic autoimmune disease affecting nearly five million people worldwide. Among all drug delivery system, oral administration is the most preferable route for colon-specific targeting and the treatment of IBD. Herein, an amphiphilic curcumin polymer (PCur) composed of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic curcumin (Cur) linked by disulfide bond was synthesized and characterized. The sufficient solubility, nano-scaled size and close to the neutral surface potential of PCur lead to preferential accumulation of the active drug in the inflamed regions of the gut...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28143596/a-scalable-algorithm-for-structure-identification-of-complex-gene-regulatory-network-from-temporal-expression-data
#7
Shupeng Gui, Andrew P Rice, Rui Chen, Liang Wu, Ji Liu, Hongyu Miao
BACKGROUND: Gene regulatory interactions are of fundamental importance to various biological functions and processes. However, only a few previous computational studies have claimed success in revealing genome-wide regulatory landscapes from temporal gene expression data, especially for complex eukaryotes like human. Moreover, recent work suggests that these methods still suffer from the curse of dimensionality if a network size increases to 100 or higher. RESULTS: Here we present a novel scalable algorithm for identifying genome-wide gene regulatory network (GRN) structures, and we have verified the algorithm performances by extensive simulation studies based on the DREAM challenge benchmark data...
January 31, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28138820/development-of-extended-release-oral-flexible-tablet-er-oft-formulation-for-pediatric-and-geriatric-compliance-an-age-appropriate-formulation
#8
Prabagaran Chandrasekaran, Ruckmani Kandasamy
Development of age-appropriate formulation suitable for pediatric and geriatric patients involves various challenges. The objective of this research was to develop extended-release oral flexible tablet (ER-OFT) formulation using carbamazepine (CBZ) as model drug for pediatric and geriatric compliance. ER-microparticles of carbamazepine, a BCS class 2, and narrow therapeutic index (NTI) drug, were prepared using ethyl cellulose as matrixing polymer and hypromellose as hydrophilic pore former. Microparticles were prepared using high-shear granulator fitted with an atomizing spray system...
January 30, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28137711/-cov-cop-allows-to-detect-cnvs-responsible-for-inherited-diseases-among-amplicons-sequencing-data
#9
P Derouault, B Parfait, R Moulinas, C-C Barrot, F Sturtz, S Merillou, A-S Lia
: In order to help molecular geneticists to rapidly identify CNVs responsible for inherited diseases among amplicons sequencing data generated by NGS, we designed a user-friendly tool "Cov'Cop". Using the run's coverage file provided by the sequencer, Cov'Cop simultaneously analyzes all the patients of the run using a two-stage algorithm containing correction and normalization levels and provides an easily understandable output, showing with various colors, potentially deleted and duplicated amplicons...
January 30, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28135856/promoter-hypermethylation-and-its-impact-on-expression-of-mgmt-gene-in-the-git-malignant-patients-of-kashmiri-origin
#10
Arif Akbar Bhat, Hilal Ahmad Wani, Shiekh Ishaq, Ajaz Ahmad Waza, Rawoof Ahmad Malik, Iram Shabir, Showkat Jeelani, Showkat Kadla, Waseem Qureshie, Akbar Masood, Sabhiya Majid
Epigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers. Gastrointestinal tract (GIT) cancer is a major medical and economic burden worldwide. Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor suppressor genes. Although a number of cancer-associated genes have been found to be hypermethylated in GIT cancer, valuable methylation markers for early diagnosis and prognostic evaluation of this cancer remain largely unknown...
January 31, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28119348/a-pragmatic-approach-to-vasculitis-in-the-gastrointestinal-tract
#11
REVIEW
Runjan Chetty, Stefano Serra
Although vasculitis involving the gastrointestinal tract (GIT) is an uncommon occurrence, occasionally vasculitis can present as haemorrhagic infarction or ischaemia for which a length of bowel is removed. Invariably, the appropriate clinical history is not forthcoming, or vasculitis is not clinically suspected. The purpose of this overview is to provide the practising gastrointestinal (GI) pathologist with a framework to recognise and diagnose vasculitides within the GIT. The classification may be approached by aetiological agent or size of vessel involved; an international consensus group now favours the latter approach...
January 24, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28116392/the-influence-of-lipid-droplet-size-on-the-oral-bioavailability-of-vitamin-d2-encapsulated-in-emulsions-an-in-vitro-and-in-vivo-study
#12
L Salvia-Trujillo, B Fumiaki, Y Park, D J McClements
Vitamin D deficiency is prevalent in some populations leading to adverse health effects, and therefore there is a need to supplement functional foods and beverages with this important micronutrient. In this study, we examined the influence of the initial lipid droplet size on the in vitro bioaccessibility and in vivo absorption of vitamin D2 encapsulated in oil-in-water emulsions. Changes in particle size, charge, and microstructure were measured as vitamin-loaded lipid droplets were passed through a simulated GIT (mouth, stomach, small intestine)...
January 24, 2017: Food & Function
https://www.readbyqxmd.com/read/28113048/large-t-antigen-variants-of-human-polyomaviruses-9-and-12-and-seroreactivity-against-their-n-terminus
#13
Sarah-Verena Korup-Schulz, Claudia Lucke, Rosa Schmuck, Ugo Moens, Bernhard Ehlers
The tumor antigens (TAgs) of mammalian polyomaviruses (PyVs) are key proteins responsible for modulating the host cell cycle and involved in virus replication as well as cell transformation and tumor formation. Here we aimed at identifying mRNA sequences of known and novel TAgs encoded by the recently discovered human polyomaviruses 9 and 12 (HPyV9 and HPyV12) in cell culture. Synthetic viral genomes were transfected into human and animal cell lines. Gene expression occurred in most cell lines, as measured by qPCR of cDNA copies of mRNA encoding major structural protein VP1...
January 22, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28107406/classification-and-segmentation-of-nanoparticle-diffusion-trajectories-in-cellular-micro-environments
#14
Thorsten Wagner, Alexandra Kroll, Chandrashekara R Haramagatti, Hans-Gerd Lipinski, Martin Wiemann
Darkfield and confocal laser scanning microscopy both allow for a simultaneous observation of live cells and single nanoparticles. Accordingly, a characterization of nanoparticle uptake and intracellular mobility appears possible within living cells. Single particle tracking allows to measure the size of a diffusing particle close to a cell. However, within the more complex system of a cell's cytoplasm normal, confined or anomalous diffusion together with directed motion may occur. In this work we present a method to automatically classify and segment single trajectories into their respective motion types...
2017: PloS One
https://www.readbyqxmd.com/read/28103395/influence-of-lipid-content-in-a-corn-oil-preparation-on-the-bioaccessibility-of-%C3%AE-carotene-a-comparison-of-low-fat-and-high-fat-samples
#15
Ziyuan Xia, David Julian McClements, Hang Xiao
Some individuals with fat maldigestion have compromised digestive systems, which causes the incomplete hydrolyzation of ingested lipids within the gastrointestinal tract (GIT). We studied the influence of high-fat (20%) and low-fat (4%) contents on the bioaccessibility of a highly hydrophobic nutraceutical (β-carotene) through a simulated GIT model consisting of mouth, stomach, and small intestine phases. The low-fat and high-fat values were chosen to simulate low-fat and high-fat diets. The triglycerides in the low-fat system were fully digested, whereas those in the high-fat system were only partially digested, thereby mimicking the digestive systems of individuals who exhibit fat maldigestion...
January 19, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28098248/microbial-succession-in-the-gastrointestinal-tract-of-dairy-cows-from-2-weeks-to-first-lactation
#16
Kimberly A Dill-McFarland, Jacob D Breaker, Garret Suen
Development of the dairy calf gastrointestinal tract (GIT) and its associated microbiota are essential for survival and milk production, as this community is responsible for converting plant-based feeds into accessible nutrients. However, little is known regarding the establishment of microbes in the calf GIT. Here, we measured fecal-associated bacterial, archaeal, and fungal communities of dairy cows from 2 weeks to the middle of first lactation (>2 years) as well as rumen-associated communities from weaning (8 weeks) to first lactation...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28087515/h-blast-a-fast-protein-sequence-alignment-toolkit-on-heterogeneous-computers-with-gpus
#17
Weicai Ye, Ying Chen, Yongdong Zhang, Yuesheng Xu
MOTIVATION: The sequence alignment is a fundamental problem in bioinformatics. BLAST is a routinely used tool for this purpose with over 118 000 citations in the past two decades. As the size of bio-sequence databases grows exponentially, the computational speed of alignment softwares must be improved. RESULTS: We develop the heterogeneous BLAST (H-BLAST), a fast parallel search tool for a heterogeneous computer that couples CPUs and GPUs, to accelerate BLASTX and BLASTP-basic tools of NCBI-BLAST...
January 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28079759/the-quantiferon-tb-gold-in-tube-assay-in-neuro-ophthalmology
#18
Leanne M Little, Mohammed Rigi, Ayman Suleiman, Stacy V Smith, Edward A Graviss, Rod Foroozan, Andrew G Lee
BACKGROUND: Although QuantiFERON-TB Gold In-Tube (QFT-GIT) testing is regularly used to detect infection with Mycobacterium tuberculosis, its utility in a patient population with a low risk for tuberculosis (TB) has been questioned. The following is a cohort study analyzing the efficacy of QFT-GIT testing as a method for detection of active TB disease in low-risk individuals in a neuro-ophthalmologic setting. METHODS: Ninety-nine patients from 2 neuro-ophthalmology centers were identified as having undergone QFT-GIT testing between January 2012 and February 2016...
January 11, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28079238/human-leukocyte-antigen-hladrb1-determinants-susceptibility-to-gastroesophageal-reflux-disease
#19
Batool Mutar Mahdi, Riyadh Mohamad Hasan, Wafaa Hazim Salih
BACKGROUND: - Gastroesophageal reflux disease (GERD) is characterized by diverse symptoms. There is an evidence for a genetic component to GERD as supported by familial aggregation of this disease. OBJECTIVE: - To investigate whether certain human leucocyte antigen genes HLA-DRB1 are associated with GERD. METHODS: - Patients and controls were prospectively recruited from GIT center at Al-Kindy Teaching Hospital (Baghdad-Iraq) between January 2014 and July 2016...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28070463/impact-of-birth-weight-and-postnatal-diet-on-the-gut-microbiota-of-young-adult-guinea-pigs
#20
Kait Al, Ousseynou Sarr, Kristyn Dunlop, Gregory B Gloor, Gregor Reid, Jeremy Burton, Timothy R H Regnault
BACKGROUND: The gastrointestinal tract (GIT) microbiota is essential to metabolic health, and the prevalence of the Western diet (WD) high in fat and sugar is increasing, with evidence highlighting a negative interaction between the GIT and WD, resulting in liver dysfunction. Additionally, an adverse in utero environment such as placental insufficiency resulting in low birth weight (LBW) offspring, contributes to an increased risk of metabolic diseases such as fatty liver infiltration and liver dysfunction in later life...
2017: PeerJ
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