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https://www.readbyqxmd.com/read/28633671/preliminary-safety-and-efficacy-profile-of-prucalopride-in-the-treatment-of-systemic-sclerosis-ssc-related-intestinal-involvement-results-from-the-open-label-cross-over-progass-study
#1
Barbara Vigone, Monica Caronni, Adriana Severino, Chiara Bellocchi, Anna Rita Baldassarri, Mirella Fraquelli, Gaia Montanelli, Alessandro Santaniello, Lorenzo Beretta
BACKGROUND: Prokinetics are used to treat enteric dismotility symptoms in systemic sclerosis (SSc) patients, but they often lack adequate efficacy. The most effective prokinetics belonging to the serotonin (5-HT4) receptor agonists class were withdrawn due to cardiac toxicity in relation to modest 5-HT4 receptor affinity. Prucalopride is a high-affinity 5-HT4 receptor agonist with no major cardiac issues, for which the efficacy in SSc has not yet been assessed. METHODS: Forty patients with self-reported mild to moderately severe enteric symptoms were enrolled in a cross-over 2 × 2 study...
June 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28624173/high-resolution-manometry-compared-with-the-university-of-california-los-angeles-scleroderma-clinical-trials-consortium-git-2-0-in-systemic-sclerosis
#2
Hanan Sayed M Abozaid, Hala M K Imam, Marwa Mahmoud Abdelaziz, Dina H El-Hammady, Nihal A Fathi, Daniel E Furst
OBJECTIVES: To study esophageal high resolution manometry (HRM) in systemic sclerosis (SSc) patients and the correlation of findings to The University of California, Los Angeles Scleroderma Clinical Trials Consortium gastrointestinal tract 2.0 (UCLA SCTC_GIT 2.0). METHODS: Forty SSc patients were administered to the UCLA SCTC GIT 2.0. Patients underwent HRM study (Solar GI MMS). HRM data were compared with 15 healthy volunteers. RESULTS: Forty patients with mean age 46 ± 7 years and disease duration 9...
May 19, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28614860/primary-fetal-lung-hypoplasia-pflh-imaging-and-clinical-characteristics
#3
Reuven Achiron, Yinon Gilboa, Yishay Salem, Yizhak Jacobson, Lisa Raviv-Zilka, Andreea Cioca, Debora Kidron, Zvi Kivilevitch
Purpose To describe in utero and postnatal imaging and clinical characteristics of primary fetal lung hypoplasia (PFLH). Methods A retrospective review of fetuses and neonates diagnosed in one academic tertiary center during an eleven-year period. Results 12 cases of PFLH were identified. 4 were bilateral and 8 had unilateral involvement. Prenatal sonographic characteristics, postnatal magnetic resonance imaging (MRI), computerized tomographic angiography (CTA), and histologic findings are described...
June 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28609116/the-underexposed-role-of-food-matrices-in-probiotic-products-reviewing-the-relationship-between-carrier-matrices-and-product-parameters
#4
Joost Flach, Mark van der Waal, Maurits van den Nieuwboer, Eric Claassen, Olaf Larsen
Probiotic microorganisms are increasingly incorporated into food matrices in order to confer proposed health benefits on the consumer. It is important that the health benefits, sensory properties, shelf-life and probiotic gastrointestinal tract (GIT) survival of these products are carefully balanced as they determine functionality and drive consumer acceptance. The strain-specific effects of probiotic species are imperative in this process but carrier matrices may play a pivotal role as well. This study therefore recapitulates the wealth of knowledge on carrier matrices and their interaction with probiotic strains...
June 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28605520/serial-tuberculosis-screening-in-inflammatory-bowel-disease-patients-under-anti-tnf%C3%AE-therapy
#5
Cândida Abreu, Joana Afonso, Cláudia Camila Dias, Rogério Ruas, António Sarmento, Fernando Magro
Background and aims: One of the adverse effects of the tumour necrosis factor-α monoclonal antibodies for the treatment of immune-mediated inflammatory diseases is a higher propensity for tuberculosis development. The aim of this study was to explore the utility and sensitivity of serial tuberculosis screening during anti-TNFα treatment. Methods: A cohort of 46 inflammatory bowel disease patients on infliximab was prospectively recruited and followed for 26 months...
June 9, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28599586/how-children-with-cerebral-palsy-master-bimanual-activities-from-a-parental-perspective
#6
Git Lidman, Kate Himmelmann, Gunilla Gosman-Hedström, Marie Peny-Dahlstrand
BACKGROUND: During childhood, children learn the daily life activities they want and need to do. Children with unilateral spastic cerebral palsy often have difficulties performing activities requiring two hands. AIM: To describe parental reasoning on how children with unilateral spastic cerebral palsy learn to master the performance of bimanual activities in everyday life. MATERIAL AND METHODS: Sixteen parents participated in focus groups, a qualitative research approach with its own methodological criteria and research methods...
June 9, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28589386/navigating-the-jungles-of-tropical-infectious-gastrointestinal-pathology-a-pattern-based-approach-to-the-endoscopic-biopsy
#7
Tomas Slavik, Gregory Y Lauwers
International travels and global human migration have had the unforeseen consequence of increasing the exposure of histopathologists in developed countries to the pathology of tropical infectious disease. The gastrointestinal tract (GIT) is often the primary site of infection due to the faecal-oral route of transmission and the high risk of exposure to contaminated water, food or soil when travelling to these regions. Whilst current microbiologic techniques are far more sensitive than histology in detecting infectious pathogens, the histopathologist nonetheless retains a pivotal role in diagnosing tropical GIT disease...
June 6, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28588563/insight-into-potential-probiotic-markers-predicted-in-lactobacillus-pentosus-mp-10-genome-sequence
#8
Hikmate Abriouel, Beatriz Pérez Montoro, Carlos S Casimiro-Soriguer, Antonio J Pérez Pulido, Charles W Knapp, Natacha Caballero Gómez, Sonia Castillo-Gutiérrez, María D Estudillo-Martínez, Antonio Gálvez, Nabil Benomar
Lactobacillus pentosus MP-10 is a potential probiotic lactic acid bacterium originally isolated from naturally fermented Aloreña green table olives. The entire genome sequence was annotated to in silico analyze the molecular mechanisms involved in the adaptation of L. pentosus MP-10 to the human gastrointestinal tract (GIT), such as carbohydrate metabolism (related with prebiotic utilization) and the proteins involved in bacteria-host interactions. We predicted an arsenal of genes coding for carbohydrate-modifying enzymes to modify oligo- and polysaccharides, such as glycoside hydrolases, glycoside transferases, and isomerases, and other enzymes involved in complex carbohydrate metabolism especially starch, raffinose, and levan...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28578960/starch-based-nanocapsules-fabricated-through-layer-by-layer-assembly-for-oral-delivery-of-protein-to-lower-gastrointestinal-tract
#9
Yiping Zhang, Chengdeng Chi, Xiaoyi Huang, Qin Zou, Xiaoxi Li, Ling Chen
Anionic carboxymethyl starch (CMS) and cationic quaternary ammonium starch (QAS), were used to fabricate nanocapsules through electrostatic layer by layer (LbL) alternate deposition onto colloidal BSA particles. An ideal starch-based colloidal nanocapsule was achieved by adjusting the degree of substitution (DS) and weight average molecular molar mass (Mw) of CMS. The nanocapsules fabricated by CMS with lower DS or Mw possessed more compact and stable core-shell structure, which favoured the BSA delivery from the upper gastrointestinal tract (GIT) to the colon...
September 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28576553/phosphate-crosslinked-pectin-based-dual-responsive-hydrogel-networks-and-nanocomposites-development-swelling-dynamics-and-drug-release-characteristics
#10
S Eswaramma, N Sivagangi Reddy, K S V Krishna Rao
Potential dual responsive hydrogel networks (PPAD) are fabricated from pectin, poly((2-dimethylamino)ethyl methacrylate)) and phosphate crosslinker bis[2-methacryloyloxy] ethyl phosphate (BMEP) by a simple free radical polymerization. These hydrogel networks are successfully utilized for encapsulation of an anti-cancer drug, 5-fluorouracil (5-FU) and also employed as versatile platforms for production of silver nanoparticles. Fabricated hydrogel networks and silver nanocomposites were characterized by FTIR, SEM, EDX, TEM, DLS, DSC, TGA and XRD...
May 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28574983/network-assisted-target-identification-for-haploinsufficiency-and-homozygous-profiling-screens
#11
Sheng Wang, Jian Peng
Chemical genomic screens have recently emerged as a systematic approach to drug discovery on a genome-wide scale. Drug target identification and elucidation of the mechanism of action (MoA) of hits from these noisy high-throughput screens remain difficult. Here, we present GIT (Genetic Interaction Network-Assisted Target Identification), a network analysis method for drug target identification in haploinsufficiency profiling (HIP) and homozygous profiling (HOP) screens. With the drug-induced phenotypic fitness defect of the deletion of a gene, GIT also incorporates the fitness defects of the gene's neighbors in the genetic interaction network...
June 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28571818/association-between-oxidative-status-and-the-composition-of-intestinal-microbiota-along-the-gastrointestinal-tract
#12
Marianna Gyuraszova, Alexandra Kovalcikova, Roman Gardlik
Studies have shown that the microbiota along the gastrointestinal tract (GIT) plays an important role when it comes to the maintenance of its proper functions. Many studies exist that have analyzed the composition of the bacterial community in the different regions of the GIT of humans and model animals. Microbial imbalance leads to several systemic disorders, including cardiovascular and renal disease. The imbalance between the production of reactive oxygen species (ROS) and their elimination by antioxidants leads to oxidative stress...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28565806/prokinetic-effects-of-ld02gifro-on-functional-gastrointestinal-disorder-in-rats
#13
Myung-Joo Choi, Hong-Mei Zheng, Hee Dong Park, Hee Kyung Jeong, Soon-Sun Hong, Jae Min Kim, Don Haeng Lee
LD02GIFRO is a novel prokinetic agent formulated with Poncirus fructus and Zanthoxylum sp. fruits. The aim of the present study was to evaluate the effect of LD02GIFRO on delayed gastrointestinal transit (GIT) and colorectal hypersensitivity. To investigate the effect of LD02GIFRO, a rat model of delayed GIT was induced via three mechanisms; postoperative ileus (POI), morphine, and POI plus morphine. Visceromotor responses (VMR) to colorectal distension (CRD) were also evaluated. POI was induced by laparotomy surgery and manipulation of the small intestine under anesthesia, and GIT was calculated by measuring the length that Evans Blue travelled through the gastrointestinal tract in a given time...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28559919/prevalence-of-latent-tuberculosis-infection-among-foreign-students-in-l%C3%A3-beck-germany-tested-with-quantiferon-tb-gold-in-tube-and-quantiferon-tb-gold-plus
#14
Elia Noemi Gallegos Morales, Johannes Knierer, Anja Schablon, Albert Nienhaus, Jan Felix Kersten
BACKGROUND: The tuberculosis (TB) incidence rate in foreign-born individuals has been increasing in Germany in recent years. Foreign students may be an important source of latent tuberculosis infection (LTBI) in low-incidence countries. In Germany, there are no guidelines for LTBI screening of foreign students. The aim of the study was to estimate LTBI prevalence and evaluate associated risk factors among foreign students in Germany. The second purpose of our study was to compare the results of the new generation of QuantiFERON-TB Gold Plus (QFT-Plus) to those of its predecessor QuantiFERON-TB Gold In-Tube (QFT-GIT)...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28556515/musculoskeletal-structure-and-function-in-response-to-the-combined-effect-of-an-obesogenic-diet-and-age-in-male-c57bl-6j-mice
#15
Kirsten N Bott, William Gittings, Val Andrew Fajardo, Bradley Baranowski, Rene Vandenboom, Paul J LeBlanc, Wendy E Ward, Sandra J Peters
SCOPE: The effects of a long-term high fat and sucrose diet (HFS) superimposed with aging on bone and muscle structure and/or function. METHODS AND RESULTS: Male C57BL/6J mice (20 weeks of age) were randomized to 1 of 3 groups: baseline (BSL, n = 12), or assigned to a control (AGE, n = 12) or HFS (HFS-AGE, n = 11) diet for 13 weeks. Trabecular bone structure, volumetric bone mineral density (vBMD), and body composition, were measured longitudinally at 20, 24, and 32 weeks of age...
May 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28552424/physicochemical-and-colloidal-aspects-of-food-matrix-effects-on-gastrointestinal-fate-of-ingested-inorganic-nanoparticles
#16
REVIEW
David Julian McClements, Hang Xiao, Philip Demokritou
Inorganic nanoparticles, such as titanium dioxide, silicon dioxide, iron oxide, zinc oxide, or silver nanoparticles, are added to some food products and food packaging materials to obtain specific functional attributes, such as lightening, powder flow, nutrition, or antimicrobial properties. These engineered nanomaterials (ENMs) all have dimensions below 100nm, but may still vary considerably in composition, morphology, charge, surface properties and aggregation state, which effects their gastrointestinal fate and potential toxicity...
May 9, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28550986/acute-deep-infections-of-the-upper-extremity-the-utility-of-obtaining-atypical-cultures-in-the-presence-of%C3%A2-purulence
#17
Nikolas H Kazmers, George W Fryhofer, Daniel Gittings, David J Bozentka, David R Steinberg, Benjamin L Gray
PURPOSE: In the setting of acute deep upper extremity infections, evidence is lacking to guide the decision whether to send atypical cultures (fungal and acid-fast-bacillus [AFB]) during surgical debridement, especially in the presence of purulent fluid that is commonly observed with typical bacterial infections. Our purpose was to determine the frequency of positive atypical cultures and the frequency with which they alter treatment, and identify factors associated with positive atypical cultures...
May 25, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28545136/assessment-of-the-quantiferon-tb-gold-in-tube-test-for-the-detection-of-mycobacterium-tuberculosis-infection-in-united-states-navy-recruits
#18
Jason M Lempp, Margan J Zajdowicz, Arlene L Hankinson, Sean R Toney, Lisa W Keep, James D Mancuso, Gerald H Mazurek
BACKGROUND: Immunologic tests such as the tuberculin skin test (TST) and QuantiFERON®-TB Gold In-Tube test (QFT-GIT) are designed to detect Mycobacterium tuberculosis infection, both latent M. tuberculosis infection (LTBI) and infection manifesting as active tuberculosis disease (TB). These tests need high specificity to minimize unnecessary treatment and high sensitivity to allow maximum detection and prevention of TB. METHODS: Estimate QFT-GIT specificity, compare QFT-GIT and TST results, and assess factor associations with test discordance among U...
2017: PloS One
https://www.readbyqxmd.com/read/28541376/dna-sequence-shape-kernel-enables-alignment-free-modeling-of-transcription-factor-binding
#19
Wenxiu Ma, Lin Yang, Remo Rohs, William Stafford Noble
Motivation: Transcription factors (TFs) bind to specific DNA sequence motifs. Several lines of evidence suggest that TF-DNA binding is mediated in part by properties of the local DNA shape: the width of the minor groove, the relative orientations of adjacent base pairs, etc. Several methods have been developed to jointly account for DNA sequence and shape properties in predicting TF binding affinity. However, a limitation of these methods is that they typically require a training set of aligned TF binding sites...
May 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28537071/clmsvault-a-software-suite-for-protein-cross-linking-mass-spectrometry-data-analysis-and-visualization
#20
Mathieu Courcelles, Jasmin Coulombe-Huntington, Émilie Cossette, Anne-Claude Gingras, Pierre Thibault, Mike Tyers
Protein cross-linking mass spectrometry (CL-MS) enables the sensitive detection of protein interactions and the inference of protein complex topology. The detection of chemical cross-links between protein residues can identify intra- and interprotein contact sites or provide physical constraints for molecular modeling of protein structure. Recent innovations in cross-linker design, sample preparation, mass spectrometry, and software tools have significantly improved CL-MS approaches. Although a number of algorithms now exist for the identification of cross-linked peptides from mass spectral data, a dearth of user-friendly analysis tools represent a practical bottleneck to the broad adoption of the approach...
June 5, 2017: Journal of Proteome Research
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