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https://www.readbyqxmd.com/read/28430385/significant-reductions-in-alcohol-use-after-hepatitis-c-treatment-results-from-the-french-anrs-co13-hepavih-cohort
#1
Rod Knight, Perrine Roux, Antoine Vilotitch, Fabienne Marcellin, Eric Rosenthal, Laure Esterle, François Boué, David Rey, Lionel Piroth, Stéphanie Dominguez, Philippe Sogni, Dominique Salmon-Ceron, Bruno Spire, Maria Patrizia Carrieri
BACKGROUND AND AIMS: Few data exist on changes to substance use patterns before and after hepatitis C virus (HCV) treatment. We used longitudinal data of HIV-HCV co-infected individuals to examine whether receiving Peg-interferon (Peg-IFN)-based therapy irrespective of HCV clearance could modify tobacco, cannabis and alcohol use. DESIGN: A prospective cohort of HIV-HCV co-infected individuals was enrolled from 2006. Participants' clinical data were retrieved from medical records and socio-demographic and behavioral characteristics were collected by yearly self-administered questionnaires...
April 21, 2017: Addiction
https://www.readbyqxmd.com/read/28426358/effects-of-workplace-generalized-and-sexual-harassment-on-abusive-drinking-among-first-year-male-and-female-college-students-does-prior-drinking-experience-matter
#2
Kathleen M Rospenda, Kaori Fujishiro, Meredith McGinley, Jennifer M Wolff, Judith A Richman
BACKGROUND: Workplace harassment, a known risk factor for adult drinking, is understudied in college samples, but may help explain observed gender differences in drinking patterns. OBJECTIVE: We examine effects of sexual and generalized workplace harassment on changes in drinking behavior over the first semesters of college, and the extent to which these effects differ based on prematriculation drinking for men and women students. METHOD: Data derive from two waves of a longitudinal study of eight Midwestern colleges and universities...
June 7, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28425109/alcoholic-cardiomyopathy-disrupted-protein-balance-and-impaired-cardiomyocyte-contractility
#3
Jennifer L Steiner, Charles H Lang
Alcoholic cardiomyopathy (ACM) can develop after consumption of relatively large amounts of alcohol over time or from acute binge drinking. Of the many factors implicated in the etiology of ACM, chronic perturbation in protein balance has been strongly implicated. This review focuses on recent contributions (since 2010) in the area of protein metabolism and cardiac function related to ACM. Data reviewed include that from in vitro and preclinical in vivo animal studies where alcohol or an oxidative metabolite was studied and outcome measures in either cardiomyocytes or whole heart pertaining to protein synthesis or degradation were reported...
April 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28425019/posttraumatic-stress-disorder-symptoms-and-problematic-overeating-behaviors-in-young-men-and-women
#4
Susan M Mason, Patricia A Frazier, S Bryn Austin, Bernard L Harlow, Benita Jackson, Nancy C Raymond, Janet W Rich-Edwards
BACKGROUND: Posttraumatic stress disorder (PTSD) is a risk factor for obesity, but the range of behaviors that contribute to this association are not known. PURPOSE: The purpose of this study was to examine associations between self-reported PTSD symptoms in 2007, with and without comorbid depression symptoms, and three problematic overeating behaviors in 2010, and to estimate the associations of PTSD-related overeating behaviors with obesity. METHODS: Cross-sectional and longitudinal analyses included 7438 male (n = 2478) and female (n = 4960) participants from the Growing Up Today Study (mean age 22-29 years in 2010)...
April 19, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28423475/primary-lymphocytic-hypophysitis-clinical-characteristics-and-treatment-of-50-cases-in-a-single-centre-in-china-over-18-years
#5
Shuchang Wang, Linjie Wang, Yong Yao, Feng Feng, Hongbo Yang, Zhiyong Liang, Kan Deng, Hui You, Jian Sun, Bing Xing, Zimeng Jin, Renzhi Wang, Hui Pan, Huijuan Zhu
OBJECTIVE: Primary lymphocytic hypophysitis (LYH) is rare and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort. DESIGN: A retrospective study of the diagnosis and treatment of primary LYH was conducted at Peking Union Medical College Hospital from 1999 to 2016. PATIENTS: Fifty patients (28 histologically-diagnosed and 22 clinically-diagnosed) were eligible for inclusion...
April 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28422117/ultrahigh-responsivity-and-detectivity-graphene-perovskite-hybrid-phototransistors-by-sequential-vapor-deposition
#6
Po-Han Chang, Shang-Yi Liu, Yu-Bing Lan, Yi-Chen Tsai, Xue-Qian You, Chia-Shuo Li, Kuo-You Huang, Ang-Sheng Chou, Tsung-Chin Cheng, Juen-Kai Wang, Chih-I Wu
In this work, graphene-methylammonium lead iodide (MAPbI3) perovskite hybrid phototransistors fabricated by sequential vapor deposition are demonstrated. Ultrahigh responsivity of 1.73 × 10(7) A W(-1) and detectivity of 2 × 10(15) Jones are achieved, with extremely high effective quantum efficiencies of about 10(8)% in the visible range (450-700 nm). This excellent performance is attributed to the ultra-flat perovskite films grown by vapor deposition on the graphene sheets. The hybrid structure of graphene covered with uniform perovskite has high exciton separation ability under light exposure, and thus efficiently generates photocurrents...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420317/the-role-of-coherence-of-mind-and-reflective-functioning-in-understanding-binge-eating-disorder-and-co-morbid-overweight
#7
Hilary Maxwell, Giorgio A Tasca, Renee Grenon, Megan Faye, Kerri Ritchie, Hany Bissada, Louise Balfour
Coherence of mind and reflective functioning may impact negative affect and interpersonal functioning over and above the effects of symptoms of depression and interpersonal problems that contribute to symptoms of binge-eating disorder (BED) and overweight/obesity. Matched samples of overweight women with BED and overweight and normal weight women without BED completed the Adult Attachment Interview, a measure of depressive symptoms, and a measure of interpersonal problems. Greater symptoms of depression distinguished women with BED from the matched comparison samples...
April 18, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28419425/how-abnormal-is-binge-eating-18-year-time-trends-in-population-prevalence-and-burden
#8
D Mitchison, S Touyz, D A González-Chica, N Stocks, P Hay
OBJECTIVE: Although findings suggest that binge eating is becoming increasingly normative, the 'clinical significance' of this behaviour at a population level remains uncertain. We aimed to assess the time trends in binge-eating prevalence and burden over 18 years. METHOD: Six cross-sectional face-to-face surveys of the Australian adult population were conducted in 1998, 2005, 2008, 2009, 2014, and 2015 (Ntotal = 15 126). Data were collected on demographics, 3-month prevalence of objective binge eating (OBE), health-related quality of life, days out of role, and distress related to OBE...
April 16, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28419251/evaluating-genetic-variants-associated-with-breast-cancer-risk-in-high-and-moderate-penetrance-genes-in-asians
#9
Mi-Ryung Han, Wei Zheng, Qiuyin Cai, Yu-Tang Gao, Ying Zheng, Manjeet K Bolla, Kyriaki Michailidou, Joe Dennis, Qin Wang, Alison M Dunning, Paul Brennan, Shou-Tung Chen, Ji-Yeob Choi, Mikael Hartman, Hidemi Ito, Artitaya Lophatananon, Keitaro Matsuo, Hui Miao, Kenneth Muir, Suleeporn Sangrajrang, Chen-Yang Shen, Soo Hwang Teo, Chiu-Chen Tseng, Anna H Wu, Cheng Har Yip, Daehee Kang, Yong-Bing Xiang, Douglas F Easton, Xiao-Ou Shu, Jirong Long
Over the past 20 years, high-penetrance pathogenic mutations in genes BRCA1, BRCA2, TP53, PTEN, STK11, and CDH1 and moderate-penetrance mutations in genes CHEK2, ATM, BRIP1, PALB2, RAD51C, RAD50, and NBN have been identified for breast cancer. In the present study, we investigated whether there are additional variants in these 13 genes associated with breast cancer among women of Asian ancestry. We analyzed up to 654 single nucleotide polymorphisms (SNPs) from 6269 cases and 6624 controls of Asian descent included in the Breast Cancer Association Consortium (BCAC), and up to 236 SNPs from 5794 cases and 5529 controls included in the Shanghai Breast Cancer Genetics Study (SBCGS)...
April 17, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28416353/eating-disorders-and-weight-control-behaviors-change-over-a-collegiate-sport-season
#10
Alexandra Thompson, Trent Petrie, Carlin Anderson
OBJECTIVES: Determine whether the prevalence of eating disorder classifications (i.e., clinical eating disorder, subclinical eating disorder, and asymptomatic) and pathogenic weight control behaviors (e.g., bingeing, vomiting) change over a five-month sport season. DESIGN: Longitudinal study. METHODS: Female collegiate gymnasts and swimmers (N=325) completed the Questionnaire for Eating Disorder Diagnoses as well as six items from the Bulimia Test-Revised at Time 1 (two weeks into the beginning of their athletic season) and Time 2 (final two weeks of the athletic season); data collections were separated by five months...
March 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28414474/abstinence-based-incentives-plus-parent-training-for-adolescent-alcohol-and-other-substance-misuse
#11
Catherine Stanger, Emily A Scherer, Steven F Babbin, Stacy R Ryan, Alan J Budney
The purpose of this study was to conduct a randomized test of clinic- and home-based incentives plus parent training for adolescent problem alcohol use. Adolescents (N = 75) with alcohol misuse, with or without other substance misuse, were enrolled. All youth received individual Motivational Enhancement Therapy/Cognitive Behavior Therapy and weekly urine drug testing. The experimental condition (EXP) included Abstinence Incentives (clinic-based incentives for abstinence from all substances) plus weekly behavioral parent training that included a parent-delivered, abstinence-based, substance monitoring contract...
April 17, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28414373/superlensing-microscope-objective-lens
#12
Bing Yan, Zengbo Wang, Alan L Parker, Yu-Kun Lai, P John Thomas, Liyang Yue, James N Monks
Conventional microscope objective lenses are diffraction limited; they cannot resolve subdiffraction features of a size smaller than 250-300 nm under white lighting condition. New innovations are required to overcome this limitation. In this paper, we propose and demonstrate a new superlensing objective lens that possesses a resolution of 100 nm, which is a two-times resolution improvement over conventional objectives. This is accomplished by integrating a conventional microscope objective lens with a superlensing microsphere lens using a customized lens adaptor...
April 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28412750/microrna-302c-3p-inhibits-renal-cell-carcinoma-cell-proliferation-by-targeting-grb2-associated-binding-2-gab2
#13
Dong-Hua Gu, Jia-Hui Mao, Xiao-Dong Pan, Hua Zhu, Xinfeng Chen, Bing Zheng, Yuxi Shan
The expression and biological function of Grb2-associated binding 2 (Gab2) in renal cell carcinoma (RCC) cells was tested here. We showed that Gab2 expression was significantly elevated in human RCC tissues and RCC cells. It was correlated with over-activation of Akt and downregulation of microRNA-302c-3p ("miR-302c-3p"), a putative Gab2-targeting microRNA. Knockdown of Gab2 inhibited Akt activation and 786-O RCC cell proliferation. Reversely, forced over-expression of Gab2 led to Akt hyper-activation to facilitate 786-O cell proliferation...
February 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411363/animal-models-of-alcoholic-liver-disease-pathogenesis-and-clinical-relevance
#14
Bin Gao, Ming-Jiang Xu, Adeline Bertola, Hua Wang, Zhou Zhou, Suthat Liangpunsakul
Alcoholic liver disease (ALD), a leading cause of chronic liver injury worldwide, comprises a range of disorders including simple steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma. Over the last five decades, many animal models that have been useful for the study of ALD pathogenesis have been developed. Recently, a chronic-plus-binge ethanol feeding model was reported. This model induces significant steatosis, hepatic neutrophil infiltration, and liver injury. A clinically relevant model of high-fat diet feeding plus binge ethanol was also developed, which highlights the risk of excessive binge drinking in obese/overweight individuals...
April 14, 2017: Gene Expression
https://www.readbyqxmd.com/read/28408897/do-executive-functions-predict-binge-drinking-patterns-evidence-from-a-longitudinal-study-in-young-adulthood
#15
Ragnhild Bø, Joël Billieux, Line C Gjerde, Espen M Eilertsen, Nils I Landrø
Background: Impairments in executive functions (EFs) are related to binge drinking in young adulthood, but research on how EFs influence future binge drinking is lacking. The aim of the current report is therefore to investigate the association between various EFs and later severity of, and change in, binge drinking over a prolonged period during young adulthood. Methods: At baseline, 121 students reported on their alcohol habits (Alcohol use disorder identification test; Alcohol use questionnaire). Concurrently, EFs [working memory, reversal, set-shifting, response inhibition, response monitoring and decision-making (with ambiguity and implicit risk)] were assessed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28399919/long-term-survival-of-high-grade-primary-peritoneal-papillary-serous-adenocarcinoma-a-case-report-and-literature-review
#16
Jingping Yuan, Liang He, Bing Han, Yan Li
BACKGROUND: Primary peritoneal papillary serous carcinoma (PPPSC) is an uncommon disease which has a high malignancy and a poor prognosis. CASE PRESENTATION: We report here a long-term survival case of PPPSC with postoperative lung metastasis. A 62-year-old female patient with PPPSC was administered two cycles of neoadjuvant chemotherapy (NAC) followed by cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) and six cycles of platinum-based (docetaxel + carboplatin) intraperitoneal chemotherapy postoperatively...
April 11, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28399487/binge-eating-disorder-may-be-distinguished-by-visuospatial-memory-deficits
#17
Kalina T Eneva, Susan M Murray, Eunice Y Chen
OBJECTIVE: Binge eating disorder (BED), characterized by recurrent episodes of loss of control overeating, is highly comorbid with overweight and obesity. Both loss of control eating and higher body mass index have been associated with poor memory. The current study sought to clarify the relationships between BED, weight and memory. Specifically, visual memory was examined, given evidence of impaired visuospatial abilities in overweight individuals and little research on visual memory in BED...
April 4, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/28397620/associations-between-early-internalizing-symptoms-and-speed-of-transition-through-stages-of-alcohol-involvement
#18
Kyle R Menary, William R Corbin, Laurie Chassin
Alcohol use disorders and internalizing disorders are highly comorbid, but how this comorbidity unfolds over development is not well understood. The present study investigated effects of internalizing symptoms in late childhood on speed of transition between three alcohol involvement milestones: first drink, first binge, and onset of first alcohol dependence symptom. Greater early internalizing symptoms were expected to predict a later age of first drink, a slower transition from first drink to first binge, and a faster transition from first binge to first dependence symptom...
April 11, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28397174/perceptions-of-chinese-biomedical-researchers-towards-academic-misconduct-a-comparison-between-2015-and-2010
#19
Qing-Jiao Liao, Yuan-Yuan Zhang, Yu-Chen Fan, Ming-Hua Zheng, Yu Bai, Guy D Eslick, Xing-Xiang He, Shi-Bing Zhang, Harry Hua-Xiang Xia, Hua He
Publications by Chinese researchers in scientific journals have dramatically increased over the past decade; however, academic misconduct also becomes more prevalent in the country. The aim of this prospective study was to understand the perceptions of Chinese biomedical researchers towards academic misconduct and the trend from 2010 to 2015. A questionnaire comprising 10 questions was designed and then validated by ten biomedical researchers in China. In the years 2010 and 2015, respectively, the questionnaire was sent as a survey to biomedical researchers at teaching hospitals, universities, and medical institutes in mainland China...
April 10, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28397063/brominated-flame-retardants-and-dechlorane-plus-on-a-remote-high-mountain-of-the-eastern-tibetan-plateau-implications-for-regional-sources-and-environmental-behaviors
#20
Xin Liu, Haijian Bing, Yanzhi Chen, Jun Li, Yanhong Wu, Gan Zhang
We investigated the occurrence of halogenated flame retardants (HFRs) including polybrominated diphenyl ethers (PBDEs), six novel brominated flame retardants (NBFRs) and dechlorane plus in air and soils on the eastern slope of Mt. Gongga on the eastern Tibetan Plateau. We detected all of the NBFR except bis(2-ethylhexyl)-tetrabromophthalate and pentabromoethyl benzene. NBFRs constituted the most prevalent group. BDE-28 and BDE-47 dominated among the PBDE congeners. Decabromodiphenyl ethane was detected at relatively high levels up to 171 pg/m(3) and 1450 pg/g dry weight in air and soils, respectively; however, it appeared to be easily degraded in the environment...
April 10, 2017: Environmental Geochemistry and Health
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