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https://www.readbyqxmd.com/read/28338004/tigar-knockdown-radiosensitizes-trxr1-overexpressing-glioma-in-vitro-and-in-vivo-via-inhibiting-trx1-nuclear-transport
#1
Yushuo Zhang, Fei Chen, Guomei Tai, Jiaojiao Wang, Jun Shang, Bing Zhang, Ping Wang, Baoxing Huang, Jie Du, Jiahua Yu, Haowen Zhang, Fenju Liu
The up-regulation of thioredoxin reductase-1 (TrxR1) is detected in more than half of gliomas, which is significantly associated with increased malignancy grade and recurrence rate. The biological functions of NADPH-dependent TrxR1 are mainly associated with reduced thioredoxin-1 (Trx1) which plays critical roles in cellular redox signaling and tumour radio-resistance. Our previous work has proved that TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown could notably radiosensitize glioma cells...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336000/high-intensity-cannabis-use-and-hiv-clinical-outcomes-among-hiv-positive-people-who-use-illicit-drugs-in-vancouver-canada
#2
Stephanie Lake, Thomas Kerr, Rielle Capler, Jeannie Shoveller, Julio Montaner, M-J Milloy
BACKGROUND: Reforms to the legal status of medical and non-medical cannabis are underway in many jurisdictions, including Canada, as are renewed efforts to scale-up HIV treatment-as-prevention (TasP) initiatives. It has been suggested that high-intensity cannabis use may be associated with sub-optimal HIV treatment outcomes. Thus, using data from a setting with a community-wide treatment-as-prevention (TasP) initiative coinciding with increasing access to medical cannabis, we sought to investigate the possible impact of high-intensity cannabis use on HIV clinical outcomes...
March 20, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28334753/alcohol-screening-among-young-people-a-prospective-study-from-the-swiss-sentinel-surveillance-system-sentinella-of-physicians-a-priori-opinions
#3
Coralie Wenger-Bonny, Adjua Alexandra N'goran, Jérôme Pasquier, Charles Dvorak, Dagmar M Haller, Lilli Herzig
Background.: Systematic screening for excessive alcohol use among young people is recommended but rarely implemented. Family practitioners tend to select patients for screening, based on their preliminary subjective opinions, which may be biased. Objective.: To evaluate the ability of family practitioners to identify excessive alcohol use among young people prior to screening them. Methods.: This prospective study was conducted through Sentinella, an epidemiological network involving 150 family practitioners across Switzerland...
February 22, 2017: Family Practice
https://www.readbyqxmd.com/read/28333240/structure-of-the-transcriptional-regulatory-network-correlates-with-regulatory-divergence-in-drosophila
#4
Bing Yang, Patricia J Wittkopp
Transcriptional control of gene expression is regulated by biochemical interactions between cis-regulatory DNA sequences and trans-acting factors that form complex regulatory networks. Genetic changes affecting both cis- and trans-acting sequences in these networks have been shown to alter patterns of gene expression as well as higher-order organismal phenotypes. Here, we investigate how the structure of these regulatory networks relates to patterns of polymorphism and divergence in gene expression. To do this, we compared a transcriptional regulatory network inferred for Drosophila melanogaster to differences in gene regulation observed between two strains of D...
February 25, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28333235/ovarian-hormones-and-obesity
#5
Brigitte Leeners, Nori Geary, Philippe N Tobler, Lori Asarian
BACKGROUND: Obesity is caused by an imbalance between energy intake, i.e. eating and energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide, and obesity pathophysiology and the resultant obesity-related disease risks differ in women and men. The underlying mechanisms are largely unknown. Pre-clinical and clinical research indicate that ovarian hormones may play a major role. OBJECTIVE AND RATIONALE: We systematically reviewed the clinical and pre-clinical literature on the effects of ovarian hormones on the physiology of adipose tissue (AT) and the regulation of AT mass by energy intake and EE...
March 2, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28329669/sun-protection-behavior-and-sunburns-among-arizona-adults
#6
Stephanie M Koch, Robin B Harris, Elizabeth T Jacobs, Kacey C Ernst, Leslie K Dennis
ObjectiveTo examine the prevalence of sun protection behaviors and sunburn history among adults in a region of the United States with high ultraviolet radiation exposure.Design and SettingData on self-reported sun protection and sunburns were obtained using supplemental questions added to the 2013 Arizona Behavioral Risk Factor Surveillance System survey. 3,370 Arizona adults over the age of 18 years completed questions about use sunscreen and protective clothing and reported sunburns within past 12 months...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28319673/the-effect-of-montelukast-on-mild-persistent-osa-after-adenotonsillectomy-in-children-a-preliminary-study
#7
Bing Wang, Jia Liang
This study sought to evaluate the treatment effect of montelukast in children with obstructive sleep apnea (OSA) after tonsillectomy and/or adenoidectomy (T&A). Fifty-eight children with persistent OSA after T&A were included and randomly divided into 2 groups: one group was administered montelukast for 12 weeks, and the other received no treatment. Clinical information, such as the apnea-hypopnea index (AHI) and nadir oxyhemoglobin saturation (nadir SpO2), was recorded. Symptoms of OSA were evaluated using the validated Pediatric Sleep Questionnaire (PSQ)...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28316813/crystal-structure-of-poly-aqua-%C3%AE-2-3-di-hydro-thieno-3-4-b-1-4-dioxine-5-7-di-carboxyl-ato-%C3%AE%C2%BA-2-o-5-o-7-%C3%AE-di-pyridin-4-yl-sulfane-%C3%AE%C2%BA-2-n-n-zinc-0-26-hydrate
#8
Wen-Liang Wu, Bing Hu
The crystal structure of the title polymer, {[Zn(C8H4O6S)(C10H8N2S)(H2O)]·0.26H2O} n , is characterized by a layered arrangement parallel to the ab plane. The zinc cation is five-coordinated in a slightly distorted trigonal-bipyramidal coordination environment defined by two pyridine ligands, two carboxyl-ate groups of two thio-phene di-carboxyl-ate ligands, and by one water mol-ecule. The ethyl-ene bridge in the dioxine ligand is disordered over two sets of sites [occupancy ratio 0.624 (9):0.376 (9)]...
March 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28306335/prognostic-value-of-normal-positron-emission-tomography-myocardial-perfusion-imaging-in-patients-with-known-or-suspected-coronary-artery-disease-a-meta-analysis
#9
A'Di Chen, HaoSen Wang, Bing Fan, YaWei Xu, Wei Chen, Neng Dai
OBJECTIVE: Several studies have confirmed high diagnostic performance of positron emission tomography (PET) myocardial perfusion imaging (MPI) in patients with known or suspected coronary artery disease (CAD). However, whether the superior diagnostic accuracy could translate into improved mortality outcomes remains unknown. The aim of this study was to define the prognostic value of normal PET MPI. METHODS: PubMed and EMBASE were searched to identify related studies up to June 2016...
March 17, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28304341/the-efficacy-of-psychological-therapies-in-reducing-weight-and-binge-eating-in-people-with-bulimia-nervosa-and-binge-eating-disorder-who-are-overweight-or-obese-a-critical-synthesis-and-meta-analyses
#10
REVIEW
Marly Amorim Palavras, Phillipa Hay, Celso Alves Dos Santos Filho, Angélica Claudino
Recurrent binge eating episodes, the core feature of Bulimia Nervosa (BN) and Binge Eating Disorder (BED), are frequently comorbid with obesity. Psychological interventions, notably Cognitive Behavioural Therapy (CBT), are effective for binge eating reduction in BED or BN but less so for weight loss. Behavioural Weight Loss Therapy (BWLT) shows effectiveness for binge eating reduction and weight loss but the latter appears poorly sustained over time. Our aim was to review evidence for efficacy of psychological therapies for BN/BED associated with overweight or obesity in reducing binge frequency and weight...
March 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28301949/phenolic-constituents-from-rheum-nobile-and-their-antioxidant-activity
#11
Ye Fei, Juan Wang, Bing Peng, Jiangnan Peng, Jing-Hong Hu, Zu-Ping Zeng, Jing Chen, Qi-En Li, Zeng-Ping Gao, Xing-Li Yan
Although the rhizomes of Rheum nobile Hook. f. et Thoms (Polygonaceae) are widely used in Tibetan medicine, no previous investigations regarding the biological activities and rarely chemical constituents of this plant have been reported. As part of an ongoing search for novel bioactive agents, a phytochemical investigation of R. nobile led to the isolation of two new compounds Rheumone B (1) and piceatannol-4'-O-β-D-(6″-O-acetyl)-glucoside (2), together with 15 known compounds by gel filtration over Sephadex LH-20 and preparative HPLC...
March 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28301468/recessive-coding-and-regulatory-mutations-in-fblim1-underlie-the-pathogenesis-of-chronic-recurrent-multifocal-osteomyelitis-crmo
#12
Allison J Cox, Benjamin W Darbro, Ronald M Laxer, Gabriel Velez, Xinyu Bing, Alexis L Finer, Albert Erives, Vinit B Mahajan, Alexander G Bassuk, Polly J Ferguson
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, pediatric, autoinflammatory disease characterized by bone pain due to sterile osteomyelitis, and is often accompanied by psoriasis or inflammatory bowel disease. There are two syndromic forms of CRMO, Majeed syndrome and DIRA, for which the genetic cause is known. However, for the majority of cases of CRMO, the genetic basis is unknown. Via whole-exome sequencing, we detected a homozygous mutation in the filamin-binding domain of FBLIM1 in an affected child with consanguineous parents...
2017: PloS One
https://www.readbyqxmd.com/read/28292966/endothelial-hif-1%C3%AE-enables-hypothalamic-glucose-uptake-to-drive-pomc-neurons
#13
Luis Varela, Shigetomo Suyama, Yan Huang, Marya Shanabrough, Matthias H Tschoep, Xiao-Bing Gao, Frank J Giordano, Tamas L Horvath
Glucose is the primary driver of hypothalamic POMC neurons. Here, we show that endothelial HIF-1α controls glucose uptake in the hypothalamus, and, that it is up-regulated in conditions of under-nourishment during which POMC neuronal activity is decreased. Endothelium-specific knockdown of HIF-1α impairs the ability of POMC neurons to adapt to the changing metabolic environment in vivo resulting in overeating of mice after food deprivation. The impaired functioning of POMC neurons was reversed ex vivo or by parenchymal glucose administration...
March 14, 2017: Diabetes
https://www.readbyqxmd.com/read/28292531/stress-overeating-and-obesity-insights-from-human-studies-and-preclinical-models
#14
REVIEW
Maria Razzoli, Carolyn Pearson, Scott Crow, Alessandro Bartolomucci
Eating disorders and obesity have become predominant in human society. Their association to modern lifestyle, encompassing calorie-rich diets, psychological stress, and comorbidity with major diseases are well documented. Unfortunately the biological basis remains elusive and the pharmacological treatment inadequate, in part due to the limited availability of valid animal models. Human research on binge eating disorder (BED) proves a strong link between stress exposure and bingeing: state-levels of stress and negative affect are linked to binge eating in individuals with BED both in laboratory settings and the natural environment...
March 11, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28291798/implantable-porous-gelatin-microspheres-sustained-release-of-bfgf-and-improved-its-neuroprotective-effect-on-rats-after-spinal-cord-injury
#15
Li Lan, Fu-Rong Tian, De-Li ZhuGe, Qi-Chuan ZhuGe, Bi-Xin Shen, Bing-Hui Jin, Jian-Ping Huang, Ming-Ze Wu, Lu-Xin Fan, Ying-Zheng Zhao, He-Lin Xu
In this study, porous gelatin microspheres (GMSs) were constructed to improve the neuroprotective effect of basic fibroblast growth factor (bFGF) on spinal cord injury. GMSs were prepared by a W/O emulsion template, followed by cross-linking, washing and drying. The particle sizes and surface porosity of the blank GMSs were carefully characterized by scan electronic microscopy. The blank GMSs have a mean particle size of 35μm and theirs surface was coarse and porous. bFGF was easily encapsulated inside the bulk GMSs through diffusion along the porous channel...
2017: PloS One
https://www.readbyqxmd.com/read/28287799/a-randomized-controlled-trial-of-a-web-based-personalized-normative-feedback-alcohol-intervention-for-young-adult-veterans
#16
Eric R Pedersen, Layla Parast, Grant N Marshall, Terry L Schell, Clayton Neighbors
OBJECTIVE: Young-adult American veterans are at risk for problematic alcohol use. However, they are unlikely to seek care and may drop out from lengthy, multicomponent treatments when they do get care. This randomized controlled trial tested a very brief alcohol intervention delivered over the Internet to reach the population of young-adult veterans to help reduce their drinking. METHOD: Veterans (N = 784) were recruited from Facebook and randomized to either a control condition or a personalized normative feedback (PNF) intervention seeking to correct drinking perceptions of gender-specific veteran peers...
March 13, 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28284117/remediation-of-organochlorine-pesticides-contaminated-lake-sediment-using-activated-carbon-and-carbon-nanotubes
#17
Shan Hua, Ji-Lai Gong, Guang-Ming Zeng, Fu-Bing Yao, Min Guo, Xiao-Ming Ou
Organochlorine pesticides (OCPs) in sediment were a potential damage for humans and ecosystems. The aim of this work was to determine the effectiveness of carbon materials remedy hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethanes (DDTs) in sediment. Two different carbon materials including activated carbon (AC) and multi-walled carbon nanotubes (MWCNTs) were used in the present research. Sediment treated with 2 wt% AC and MWCNTs after 150 d contact showed 97%, and 75% reduction for HCH, and 93% and 59% decrease for DDTs in aqueous equilibrium concentration, respectively...
March 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/28282268/construction-of-recombinant-yarrowia-lipolytica-and-its-application-in-bio-transformation-of-lignocellulose
#18
Hui-Ting Song, Yi-Min Yang, Ding-Kang Liu, Xiao-Qing Xu, Wen-Jing Xiao, Zi-Lu Liu, Wu-Cheng Xia, Chao-Ying Wang, Xiao Yu, Zheng-Bing Jiang
Lignocellulose is a polysaccharide and an abundant biomass resource that widely exists in grains, beans, rice, and their by-products. Over 10 million tons of lignocellulose resources and processing products are produced every year in China. Three recombinant Y. lipolytica strains with cellulase (β-glucosidase, endoglucanase and cellobiohydrolase) were constructed. The enzymatic activities of these enzymes were 14.181 U/mL, 16.307 U/mL, and 17.391 U/mL, respectively. The whole cell cellulases were used for a stover bio-transformation...
February 17, 2017: Bioengineered
https://www.readbyqxmd.com/read/28280885/acute-stress-worsens-the-deficits-in-appetitive-behaviors-for-social-and-sexual-stimuli-displayed-by-rats-after-long-term-withdrawal-from-morphine
#19
Yunjing Bai, David Belin, Xigeng Zheng, Zhengkui Liu, Yue Zhang
RATIONALE: Negative affective states, e.g., anhedonia, are suggested to be involved in the long-lasting motivational processes associated with relapse. Here, we investigated whether anhedonic behaviors could be elicited by an acute stress after protracted abstinence from morphine. OBJECTIVES: The behavioral responses to natural stimuli following exposure to an acute stress were examined after 14 days of withdrawal from morphine. Male rats were pretreated with either a binge-like morphine regimen or daily saline injections for 5 days...
March 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28279017/germination-of-seeds-and-seedling-growth-of-amaranthus-retroflexus-l-following-sublethal-exposure-of-parent-plants-to-herbicides
#20
Yue Qi, Bing Yan, Gang Fu, Xiao Guan, Leshan Du, Junsheng Li
Herbicides have long-term effects on the vegetative parts and reproduction of plants; however, the carry-over effects of herbicides on the F1 generation of invasive plants remain unclear. The objectives of this work were to investigate the germination and growth of the F1 generation of A. retroflexus, an invasion plant, treated by sublethal herbicides. The results demonstrated that atrazine or tribenuron-methyl had carry-over effects on the F1 generation of A. retroflexus. Atrazine or tribenuron-methyl exposure during the vegetative and reproductive periods significantly inhibited the germination and growth of the F1 generation; a lower sublethal dose of atrazine or tribenuron-methyl did not weaken the inhibition of germination or growth of the F1 generation...
December 2017: Scientific Reports
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