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https://www.readbyqxmd.com/read/29154552/does-shyness-interact-with-peer-group-affiliation-in-predicting-substance-use-in-adolescence
#1
Alexandre Lemyre, Natalia Poliakova, Frank Vitaro, Richard E Tremblay, Michel Boivin, Richard E Bélanger
Cigarette use and binge drinking are risky behaviors emerging during adolescence. Although many beneficial factors are well documented, studies linking shyness to substance use are somehow conflicting, which may be due to the contribution of moderators. Therefore, the present study has 2 objectives: (a) to prospectively analyze the association between shyness and substance use during adolescence, and (b) to test the moderating role of peer group affiliation on the relationship between shyness and substance use...
November 20, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29147436/repeated-multiple-neurofibromatosis-type-1-in-the-right-lower-limb-a-case-report
#2
Leitao Huang, Yi Ding, Lai Qi, Xia Wu, Wei Li, Gendong Huang, Min Dai, Bing Zhang
Neurofibromatosis type 1 (NF1) is an autosomal-dominant genetic disease characterized by the presence of multiple neurofibromas. We encountered a unique case of NF1 that manifested as a recurrent soft tissue neurofibroma in the right lower limb that developed over a period of 16 years. The patient presented with a painless mass that was initially diagnosed as inflammatory changes via computed tomography and magnetic resonance imaging. However, the condition was subsequently diagnosed as an intraneural neurofibroma via pathological and immunohistochemical examination, which showed a focal to patchy lymphocytic chronic inflammatory infiltrate and several non-encapsulated masses with clear boundaries that were easily distinguishable from the adjacent neurofibroma...
April 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29144185/rest-activity-circadian-rhythm-and-sleep-quality-in-patients-with-binge-eating-disorder
#3
E Roveda, A Montaruli, L Galasso, C Pesenti, E Bruno, P Pasanisi, M Cortellini, S Rampichini, S Erzegovesi, A Caumo, F Esposito
Recent findings suggest that altered rest-activity circadian rhythms (RARs) are associated with a compromised health status. RARs abnormalities have been observed also in several pathological conditions, such as cardiovascular, neurological, and cancer diseases. Binge eating disorder (BED) is the most common eating disorder, with a prevalence of 3.5% in women and 2% in men. BED and its associate obesity and motor inactivity could induce RARs disruption and have negative consequences on health-related quality of life...
November 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29141843/stable-sr-electrophysiological-substrate-ablation-in-the-left-atrium-during-sinus-rhythm-for-the-treatment-of-nonparoxysmal-atrial-fibrillation-a-prospective-multicenter-randomized-clinical-trial
#4
Bing Yang, Chenyang Jiang, Yazhou Lin, Gang Yang, Huimin Chu, Heng Cai, Fengmin Lu, Xianzhang Zhan, Jian Xu, Xinhua Wang, Chi-Keong Ching, Balbir Singh, Young-Hoon Kim, Minglong Chen
BACKGROUND: Circumferential pulmonary vein isolation (CPVI) alone or combined with adjuvant substrate modifications is unsatisfactory for atrial fibrillation (AF) control in nonparoxysmal AF patients. Ablation targeting the fibrotic areas after CPVI (STABLE-SR [Electrophysiological Substrate Ablation in the Left Atrium During Sinus Rhythm]) is a newly evolved substrate modification strategy. METHODS AND RESULTS: In this multicenter, randomized clinical trial, 229 symptomatic nonparoxysmal AF patients were 1:1 randomized to STABLE-SR group (n=114) or conventional STEPWISE group (n=115)...
November 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29141211/lateral-preoptic-control-of-the-lateral-habenula-through-convergent-glutamate-and-gaba-transmission
#5
David J Barker, Jorge Miranda-Barrientos, Shiliang Zhang, David H Root, Hui-Ling Wang, Bing Liu, Erin S Calipari, Marisela Morales
The lateral habenula (LHb) is a brain structure that participates in cognitive and emotional processing and has been implicated in several mental disorders. Although one of the largest inputs to the LHb originates in the lateral preoptic area (LPO), little is known about how the LPO participates in the regulation of LHb function. Here, we provide evidence that the LPO exerts bivalent control over the LHb through the convergent transmission of LPO glutamate and γ-aminobutyric acid (GABA) onto single LHb neurons...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29140165/improved-total-body-irradiation-survival-by-delivery-of-two-radiation-mitigators-that-target-distinct-cell-death-pathways
#6
Justin Steinman, Michael Epperly, Wen Hou, John Willis, Hong Wang, Renee Fisher, Bing Liu, Ivet Bahar, Travis McCaw, Valerian Kagan, Hulya Bayir, Jian Yu, Peter Wipf, Song Li, M Saiful Huq, Joel S Greenberger
The acute lethality of total-body irradiation (TBI) involves damage to multiple organs, including bone marrow and intestine. Ionizing radiation mitigators that are effective when delivered 24 h or later after TBI include the anti-apoptotic drug, JP4-039 and the anti-necroptotic drug, necrostatin-1. In contrast to effective delivery of JP4-039 at 24 h after TBI, necrostatin-1 is most effective when delivery is delayed until 48 h, a time that correlates with the elevation of necroptosis-inducing inflammatory cytokines and necroptosis-induced serine phosphorylation of receptor-interacting serine/threonine-protein kinase-3 (RIP3) in tissues...
November 15, 2017: Radiation Research
https://www.readbyqxmd.com/read/29135239/advances-in-sulfidation-of-zerovalent-iron-for-water-decontamination
#7
Jinxiang Li, Xueying Zhang, Yuankui Sun, Liping Liang, Bing-Cai Pan, Weiming Zhang, Xiaohong Guan
Sulfidation has gained increasing interest in recent years for improving the sequestration of contaminants by zerovalent iron (ZVI). In view of the bright prospects of the sulfidated ZVI (S-ZVI), this review comprehensively summarized the latest developments in sulfidation of ZVI, particularly that of nanoscale ZVI (S-nZVI). The milestones in development of S-ZVI technology including its background, enlightenment, synthesis, characterization, water remediation and treatment, etc., are summarized. Under most circumstances, sulfidation can enhance the sequestration of various organic compounds and metal(loid)s by ZVI to various extents...
November 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29134527/the-removal-of-cod-and-nh3-n-from-atrazine-production-wastewater-treatment-using-uv-o3-experimental-investigation-and-kinetic-modeling
#8
Liang Jing, Bing Chen, Diya Wen, Jisi Zheng, Baiyu Zhang
In this study, a UV/O3 hybrid advanced oxidation system was used to remove chemical oxygen demand (COD), ammonia nitrogen (NH3-N), and atrazine (ATZ) from ATZ production wastewater. The removal of COD and NH3-N, under different UV and O3 conditions, was found to follow pseudo-first-order kinetics with rate constants ranging from 0.0001-0.0048 and 0.0015-0.0056 min(-1), respectively. The removal efficiency of ATZ was over 95% after 180 min treatment, regardless the level of UV power. A kinetic model was further proposed to simulate the removal processes and to quantify the individual roles and contributions of photolysis, direct O3 oxidation, and hydroxyl radical (OH·) induced oxidation...
November 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29118398/updating-the-geologic-barcodes-for-south-china-discovery-of-late-archean-banded-iron-formations-in-the-yangtze-craton
#9
Hui Ye, Chang-Zhi Wu, Tao Yang, M Santosh, Xi-Zhu Yao, Bing-Fei Gao, Xiao-Lei Wang, Weiqiang Li
Banded iron formations (BIFs) in Archean cratons provide important "geologic barcodes" for the global correlation of Precambrian sedimentary records. Here we report the first finding of late Archean BIFs from the Yangtze Craton, one of largest Precambrian blocks in East Asia with an evolutionary history of over 3.3 Ga. The Yingshan iron deposit at the northeastern margin of the Yangtze Craton, displays typical features of BIF, including: (i) alternating Si-rich and Fe-rich bands at sub-mm to meter scales; (ii) high SiO2 + Fe2O3total contents (average 90...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118011/comparative-genome-analysis-of-programmed-dna-elimination-in-nematodes
#10
Jianbin Wang, Shenghan Gao, Yulia Mostovoy, Yuanyuan Kang, Maxim Zagoskin, Yongqiao Sun, Bing Zhang, Laura K White, Alice Easton, Thomas B Nutman, Pui-Yan Kwok, Songnian Hu, Martin K Nielsen, Richard E Davis
Programmed DNA elimination is a developmentally regulated process leading to the reproducible loss of specific genomic sequences. DNA elimination occurs in unicellular ciliates and a variety of metazoans, including invertebrates and vertebrates. In metazoa, DNA elimination typically occurs in somatic cells during early development, leaving the germline genome intact. Reference genomes for metazoa that undergo DNA elimination are not available. Here, we generated germline and somatic reference genome sequences of the DNA eliminating pig parasitic nematode Ascaris suum and the horse parasite Parascaris univalens...
November 8, 2017: Genome Research
https://www.readbyqxmd.com/read/29113503/effects-of-crystalline-state-and-self-nanoemulsifying-drug-delivery-system-snedds-on-oral-bioavailability-of-the-novel-anti-hiv-compound-6-benzyl-1-benzyloxymethyl-5-iodouracil-in-rats
#11
Ying-Yuan Lu, Wen-Bing Dai, Xin Wang, Xiao-Wei Wang, Jun-Yi Liu, Pu Li, Ya-Qing Lou, Chuang Lu, Qiang Zhang, Guo-Liang Zhang
The objective of this study was to investigate the effect of crystalline state and a formulation of self-nanoemulsifying drug delivery system (SNEDDS) on oral bioavailability of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor, in rats. The crystalline states of W-1 were characterized by scanning electron microscope (SEM), differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD). The SNEDDS was formulated by medium-chain lipids, characterized by droplet particle size...
November 8, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29113456/a-systematic-review-of-cost-effectiveness-studies-of-prevention-and-treatment-for-eating-disorders
#12
Long Khanh-Dao Le, Phillipa Hay, Cathrine Mihalopoulos
BACKGROUND: Eating disorders are serious mental disorders and are associated with substantial economic and social burden. The aim of this study is to undertake a systematic review of the cost-effectiveness studies of both preventive and treatment interventions for eating disorder. METHOD: Electronic databases (including the Cochrane Controlled Trial Register, MEDLINE, PsycINFO, Academic Search Complete, Global Health, CINAHL complete, Health Business Elite, Econlit, Health Policy Reference Center and ERIC) were searched for published cost-effectiveness studies of eating disorder prevention and treatment including papers published up to January 2017...
November 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29112895/polyactin-a-is-a-novel-and-potent-immunological-adjuvant-for-peptide-based-cancer-vaccine
#13
Wei Wang, Yanqin Li, Yawen Wang, Shuting Ren, Yiping Li, Bing Wang
Synthetic peptide cancer vaccines are poorly immunogenic sub-unit vaccines and thus essentially need adjuvants in their formulations to increase the efficacy by enhancing the peptide-specific immune response. However, aluminum-based compounds are almost dependent for clinical use at present. Therefore, the increasing use of peptide-based vaccines makes the need for novel and potent adjuvants. Polyactin A (PAA) has been used for the clinical treatment of impaired immunity in China for over 30years. To figure out the adjuvant effects of PAA for E75 peptide breast cancer vaccine (Her2 p369-p377), the generation of mature dendritic cells (DCs) from peripheral blood monocytes (PBMCs) cultured with PAA, IL-4 and TNF-α was assessed by morphologic features and the expressions of special surface markers using flow cytometry...
November 4, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29112884/appearance-based-rejection-sensitivity-as-a-mediator-of-the-relationship-between-symptoms-of-social-anxiety-and-disordered-eating-cognitions-and-behaviors
#14
Jake Linardon, Rachel Braithwaite, Rachel Cousins, Leah Brennan
Previous research has established a robust relationship between symptoms of social anxiety and disordered eating. However, the mechanisms that may underpin this relationship are unclear. Appearance-based rejection sensitivity (ABRS)-the tendency to anxiously expect and overreact to signs of appearance-based rejection-may be a crucial explanatory mechanism, as ABRS has been shown to maintain social anxiety symptoms and predict disordered eating. We therefore tested whether ABRS mediated the relationship between social anxiety symptoms and various indices of disordered eating (over-evaluation of weight/shape, restraint, binge eating, compulsive exercise, and vomiting)...
October 31, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/29112288/a-preliminary-study-of-momentary-naturalistic-indicators-of-binge-eating-episodes-in-adults-with-obesity
#15
Andrea B Goldschmidt, Ross D Crosby, Li Cao, Stephen A Wonderlich, James E Mitchell, Scott G Engel, Carol B Peterson
OBJECTIVES: Binge eating is common in adults with obesity. The Diagnostic and Statistical Manual for Psychiatric Disorders describes five indicators of binge eating (eating more rapidly than usual; eating until uncomfortably full; eating large amounts of food when not physically hungry; eating alone because of embarrassment over how much one is eating; and feeling disgusted with oneself, depressed, or very guilty after overeating), but their validity is unclear. METHOD: We examined preliminary associations between the five indicators and binge versus nonbinge episodes among 50 adults with obesity via ecological momentary assessment...
November 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29109016/modifiable-predictors-of-insufficient-sleep-durations-a-longitudinal-analysis-of-youth-in-the-compass-study
#16
Karen A Patte, Wei Qian, Scott T Leatherdale
The purpose of the current study was to simultaneously examine commonly proposed risk and protective factors for sleep deprivation over time among a large cohort of Ontario and Alberta secondary school students. Using 4-year linked longitudinal data from youth in years 1 through 4 (Y1[2012/2013], Y2[2013/2014], Y3[2014/2015], Y4[2015/2016]) of the COMPASS study (n=26,205), the likelihood of students meeting contemporary sleep recommendations was tested based on their self-reported substance use, bullying victimization, physical activity, and homework and screen time...
November 9, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29104448/generalizing-dtw-to-the-multi-dimensional-case-requires-an-adaptive-approach
#17
Mohammad Shokoohi-Yekta, Bing Hu, Hongxia Jin, Jun Wang, Eamonn Keogh
In recent years Dynamic Time Warping (DTW) has emerged as the distance measure of choice for virtually all time series data mining applications. For example, virtually all applications that process data from wearable devices use DTW as a core sub-routine. This is the result of significant progress in improving DTW's efficiency, together with multiple empirical studies showing that DTW-based classifiers at least equal (and generally surpass) the accuracy of all their rivals across dozens of datasets. Thus far, most of the research has considered only the one-dimensional case, with practitioners generalizing to the multi-dimensional case in one of two ways, dependent or independent warping...
January 2017: Data Mining and Knowledge Discovery
https://www.readbyqxmd.com/read/29101819/simultaneous-quantification-of-five-biflavonoids-in-rat-plasma-by-lc-esi-ms-ms-and-its-application-to-a-comparatively-pharmacokinetic-study-of-selaginella-doederleinii-hieron-extract-in-rats
#18
Bing Chen, Xuewen Wang, Yulian Zou, Weiying Chen, Gang Wang, Wensong Yao, Peiying Shi, Shaoguang Li, Shilan Lin, Xinhua Lin, Hong Yao
Selaginella doederleinii Hieron is a widely used as folk Chinese medicine for treatment of different cancers. Our previous investigations have confirmed that the total biflavonoids in ethyl acetate extract from S. doederleinii (SDEA) have favorable anticancer potentials. However, the in vivo process of its bioactive ingredients remains unknown. In this paper, a sensitive and reliable method was developed for simultaneous quantification of main five biflavonoids, including amentoflavone, robustaflavone, 2″,3″-dihydro-3',3″-biapigenin, 3',3″-binaringenin and delicaflavone in the ethyl acetate extract of S...
October 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29100284/exosomes-containing-differential-expression-of-microrna-and-mrna-in-osteosarcoma-that-can-predict-response-to-chemotherapy
#19
Ji-Feng Xu, Ya-Ping Wang, Shui-Jun Zhang, Yu Chen, Hai-Feng Gu, Xiao-Fan Dou, Bing Xia, Qing Bi, Shun-Wu Fan
A major challenge in osteosarcoma (OS) is the selection of the most effective chemotherapeutic agents for individual patients, while the administration of ineffective chemotherapy increases mortality and decreases quality of life in patients. This emphasizes the need to evaluate every patient's probability of responding to each chemotherapeutic agent. We developed a profiling strategy for serum exosomal microRNAs and mRNAs in OS patients with differential chemotherapeutic responses. Twelve miRNAs were up regulated and 18 miRNAs were under regulated significantly in OS patient with poor chemotherapeutic response when compared with those in good chemotherapeutic response (p<0...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098749/to-go-or-not-to-go-a-proof-of-concept-study-testing-food-specific-inhibition-training-for-women-with-eating-and-weight-disorders
#20
Robert Turton, Bruno P Nazar, Emilee E Burgess, Natalia S Lawrence, Valentina Cardi, Janet Treasure, Colette R Hirsch
Inefficient food-specific inhibitory control is a potential mechanism that underlies binge eating in bulimia nervosa and binge eating disorder. Go/no-go training tools have been developed to increase inhibitory control over eating impulses. Using a within-subjects design, this study examined whether one session of food-specific go/no-go training, versus general inhibitory control training, modifies eating behaviour. The primary outcome measure was food consumption on a taste test following each training session...
November 3, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
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