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Andres de la Espriella Rosales, Nadia Lucila Rocha Brito, Renato Frucchi, Gustavo Constantino de Campos, Alexandre Felicio Pailo, Márcia Uchôa de Rezende
OBJECTIVE: To evaluate the relationship between BMI and pain and function in patients with OA undergoing medical treatment following OARSI recommendations. METHODS: Thirty-eight patients were classified according to their arthritis degree by X-ray and body mass index (BMI). All patients completed the WOMAC, Lequesne, and visual analogue pain scale (VAS) questionnaires at baseline and after six months treatment. All patients were treated with diacerhein and analgesics (according to pain), orthotics (when indicated), and an educational program on osteoarthritis...
2014: Acta Ortopedica Brasileira
B Tong, B Wan, Z Wei, T Wang, P Zhao, Y Dou, Z Lv, Y Xia, Y Dai
Cathepsin B (CB), an important proteinase that participates in joint destruction in rheumatoid arthritis (RA), exhibits higher expression in fibroblast-like synoviocyte (FLS) of abnormal proliferative synovial tissues. Whether and how it affects the biological behaviours of RA-FLS, such as migration and invasion, are poorly understood. In the present study, CB expression in synovial tissues of patients with RA and ostearthritis (OA) were measured by quantitative polymerase chain reaction (qPCR) and immunohistochemistry (IHC), respectively...
September 2014: Clinical and Experimental Immunology
P Tornero-Esteban, J A Hoyas, E Villafuertes, I Garcia-Bullón, E Moro, B Fernández-Gutiérrez, F Marco
OBJECTIVE: MiRNAs act as gene silencers that are involved in the regulation of essential cell functions. miR-335 is involved in regulating cell differentiation processes in progenitor cells. Mesenchymal stem cells (MSCs) are progenitor cells of chondrocytes and osteoblasts responsible for homeostatic maintenance of cartilage and bone. The aim of this study was to determine a possible relationship between the expression of miR-335 and osteoarthritis. METHODS: MSCs obtained from the bone marrow of 3 osteoarthritic patients and 3 controls with no clinical signs of osteoarthritis or osteoporosis were cultured and phenotypically and functionally characterised in a 3-step culture...
May 2014: Revista Española de Cirugía Ortopédica y Traumatología
Thisara Weerasuriya, Raja Swaminathan
Synovial oteochondromatosis has been described in the knee joint commonly but this case was in the elbow and was associated with ulnar nerve palsy. Generally it has been the belief that synovial osteochondromatosis is not associated with ostearthritis of the joint but, in this case it was clearly associated with osteoarthritis of the elbow. Therefore the authors wish to report this case of a rare condition with an unusual association.
2011: BMJ Case Reports
Javier Conde, Morena Scotece, Rodolfo Gómez, Veronica Lopez, Juan Jesus Gómez-Reino, Oreste Gualillo
Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines...
2011: Arthritis
M Netval, R Branald, T Hudec
The authors deal with a rare case of a 14-year actinomycotic affection of the left lower limb in at present 39 years old female patient. They point out the difficulty and mistakes in the diagnosis of the mentioned disease. During the 14 years the patient was hospitalized, examined and treated at approximately 6-7 clinics all over the republic with different conclusions within the differential diagnosis. It is a fact that the history of the patient was underestimated, not all possibilities of the examination within differential diagnosis were used and at one clinic the histological finding got even lost, the examination was not repeated and the treatment focussed only on the incipient symptoms of the disease...
2000: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
H Wangen, P Lereim, I Holm, R Gunderson, O Reikerås
It is well accepted that youth and high activity levels are among the factors that increase the risk of mechanical failure of total hip prostheses. However, there are few reports of long-term results in very young patients. In this study, we evaluated the results of total 49 hip replacements (THRs) using an uncemented total hip prosthesis in 44 patients (28 females) who were 30 years or younger (range: 15-30 years). The diagnosis was ostearthritis due to congenital dislocations in 28 patients, with the remaining patients having diagnoses of sequelae of fracture, infection, Calve-Legg-Perthes disease, avascular necrosis, chondrodystrophia and epiphyseal dysplasia...
April 2008: International Orthopaedics
M Tinius, S Klima, W Tinius, C Josten
Opinions differ on unicompartmental knee replacement for treatment of unicompartmental ostearthritis of the knee. There is general agreement that well-functioning cruciate ligaments are necessary if use of this prosthesis is to be successful. Especially for younger people who are still working and who have advanced medial arthritis and lacking or inadequate anterior cruciate ligament, this therapy has its limitations. To exploit the advantages of unicondylar replacement in such patients, we combined this joint replacement operation with reconstruction of the anterior cruciate ligament using the semitendinosus/gracilis tendon and applying a transfix technique in 7 cases...
December 2006: Der Unfallchirurg
M Kaliakatsos, M Tzetis, E Kanavakis, P Fytili, G Chouliaras, Th Karachalios, K Malizos, A Tsezou
Ostearthritis (OA) is characterized by focal areas of loss of the articular cartilage in synovial joints, associated with varying degrees of osteophyte formation, subchondral bone change and synovitis. The Asporin (ASPN) gene which encodes a protein of the extracellular cartilage matrix contains a triplet repeat encoding for aspartic acid (D) within exon 2 The D14 allele was found associated with knee and hip osteoarthritis in case-control study in the Japanese population. Genotyping Greek knee OA patients for the D repeats we determined that the D15 allele could be considered a risk allele for our population...
June 2006: Osteoarthritis and Cartilage
J P Brutus, L Kinnen
INTRODUCTION: We have reviewed the short-term results of the ARPE arthroplasty of the first carpometacarpal joint for osteoarthritis of the thumb. MATERIAL AND METHODS: One hundred and eighteen patients have been operated on in our department between June 1999 and June 2003, by the same surgeon. Sixty-three of these patients had been followed for a minimum of six months and were included in this retrospective study. We have evaluated functional results as pain, key-pinch, mobility and patient satisfaction...
October 2004: Chirurgie de la Main
N Doumbouya, A M N'Goan-Domoua, C Aguehounde, S De Silva-Anoma, C Roux
From an analysis of two files of children carriers of primitive psoas abscess, the authors report the difficulties of diagnosis due to the rarity of this affection and the similarities of its symptomatology with ostearthritis of the hip which is a common pathology at the pediatric surgery unit of C.H.U. Yopougon (Republic of Côte d'Ivoire). A non surgical treatment made of antibiotherapy and traction fixed in the axis of the limb is proposed, since it helped the two patients who had presented an echographical stage II of psoas abcess to recover without after-effects...
1998: Bulletin de la Société de Pathologie Exotique
J Croce, E T de Carvalho Filho, U Pasini, L C Do Serro Azul
UNLABELLED: Cellular immunity of persons over 60 years of age was evaluated by intradermal testing with ubiquitous antigens, such as PPD, Trichophytin, Candidine and Varidase (SK, SD-40-10 U/ml) and by skin sensitization with DNCB. The group consisted of 290 individuals, 95 men and 195 women, without any signs of disease other than the usual geriatric disturbances, such as osteoporosis, ostearthritis and mild systolic hypertension. No medication was used that could interfere with the results of the tests...
March 1984: Allergologia et Immunopathologia
J Walker
In a double blind study, repeated irradiation with a low-power (1 mW) helium-neon laser produced relief in subjects with chronic pain. Analgesia was observed after exposure of the skin overlying the radial, medial and saphenous nerves and in some cases, irradiation of the appropriate painful nerve. Exposure of areas of skin not innervated by these nerves did not result in pain relief. Of the patients with trigeminal neuralgia, post-herpetic neuralgia, sciatica and ostearthritis, 19 of 26 experienced pain relief without the use of drugs...
December 30, 1983: Neuroscience Letters
G Kaiser
The author describes the various origins of osteoarthrosis following hip joint injuries. Since beginning osteoarthrosis can't be stoped, he emphasizes the surgical treatment of joint fractures including accurate reduction and stabilization of the fragments. In respect of this, intracapsular fractures of the neck of the femur always require a stabile fixation. In all cases the micro-injuries of the articular cartilage should be considered. The different possibilities of post-traumatic degenerative arthritis are discussed and the methods of operative procedures presented...
1976: Zentralblatt Für Chirurgie
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