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https://www.readbyqxmd.com/read/28938783/phytochemicals-reduce-aflatoxin-induced-toxicity-in-chicken-embryos
#1
Hsin-Bai Yin, Chi-Hung Chen, Michael J Darre, Ann M Donoghue, Dan J Donoghue, Kumar Venkitanarayanan
Aflatoxins (AF) are toxic metabolites produced by molds, Aspergillus flavus and Aspergillus parasiticus, which frequently contaminate poultry feed ingredients. Ingestion of AF-contaminated feed by chickens leads to deleterious effects, including decreased bird performance and reduced egg production. Moreover, AF residues in fertilized eggs result in huge economic losses by decreasing embryo viability and hatchability. This study investigated the efficacy of 2 generally recognized as safe phytochemicals, namely carvacrol (CR) and trans-cinnamaldehyde (TC), in protecting chicken embryos from AF-induced toxicity...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938493/acute-and-chronic-impact-of-bariatric-surgery-on-plasma-ldl-cholesterol-and-pcsk9-levels-in-patients-with-severe-obesity
#2
Marjorie Boyer, Marie-Eve Piché, Audrey Auclair, Thomas Grenier-Larouche, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Simon Biron, Stéfane Lebel, Odette Lescelleur, François Julien, Julie Martin, André Tchernof, André C Carpentier, Paul Poirier, Benoit J Arsenault
Context: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein cholesterol (LDL-C) concentrations. In patients with severe obesity, biliopancreatic diversion with duodenal switch (BPD-DS) surgery induces substantial weight loss and favourably influence lipoprotein metabolism. The impact of BPD-DS surgery on PCSK9 levels is unknown. Objectives: To determine the acute and chronic impact of BPD-DS surgery on PCSK9 levels and whether the acute impact of BPD-DS could be explained by BPD-DS surgery-associated caloric restriction (CR)...
August 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938488/ovarian-aging-in-women-with-brca-germline-mutations
#3
Wayne Lin, Shiny Titus, Fred Moy, Elizabeth S Ginsburg, Kutluk Oktay
Context: Recent clinical and laboratory studies suggested that women with BRCA mutations have lower ovarian reserve and their primordial follicle oocytes may be more prone to DNA damage but the direct proof is lacking. Objective: To determine whether women with germline BRCA mutations have reduced primordial follicle reserve and increased oocyte DNA damage. Design: A laboratory comparative study of ovarian tissue obtained from the risk-reducing salpingo- oophorectomy (RRSO) samples of unaffected BRCA mutation carrier (BMC) women vs...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938473/the-role-of-episodic-postprandial-peptides-in-exercise-induced-compensatory-eating
#4
Catherine Gibbons, John E Blundell, Phillipa Caudwell, Dominic-Luc Webb, Per M Hellström, Erik Näslund, Graham Finlayson
Purpose: Prolonged physical activity gives rise to variable degrees of body weight and fat loss, and is associated with variability in appetite control (hunger and energy intake). Whether these effects are modulated by postprandial 'episodic' peptides is unclear. We examined the role of postprandial peptide response in compensatory eating during 12-weeks aerobic exercise and in response to high (HFLC) and low fat (LFHC) meals. Methods: 32 overweight/obese individuals - 16 completed 12-weeks aerobic exercise and 16 were age- and BMI-matched non-exercising controls...
August 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938392/segmental-bone-loss-reconstruction-using-ring-fixation
#5
Stephen M Quinnan
Ring fixation is a powerful tool in the treatment of bone defects. The ability to create high-quality, biologically normal new bone of even massive proportions using distraction osteogenesis is a major reason for its success. In addition, ring fixation provides the ability to limit the risk of deep infection, improves flexibility in limb length control and alignment, and increases soft tissue coverage options. The drawbacks of ring fixation include long frame times, pin problems, risk of joint contractures, and difficult usage in areas with a large soft tissue envelope such as the thigh...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938286/optimizing-bone-defect-reconstruction-balanced-cable-transport-with-circular-external-fixation
#6
Stephen Matthew Quinnan, Charles Lawrie
Distraction osteogenesis has proven effective in the management of tibial bone loss from severe trauma and infection. Unfortunately, pain and scarring from wires and half pins dragging through the skin and the required prolonged time in the external fixator make treatment difficult. Cable bone transport has been shown to improve cosmesis and decrease pain during transport. However, the published methods have limitations in that they have poor control of transport segment alignment, do not allow for lengthening of the limb, and do not permit weight bearing during the treatment process...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938283/effect-of-tranexamic-acid-on-transfusion-a-randomized-clinical-trial-in-acetabular-fracture-surgery
#7
William D Lack, Brett D Crist, Rachel B Seymour, William Harvin, Madhav A Karunakar
OBJECTIVES: Given the increasing evidence that minimizing blood loss and limiting allogeneic transfusion can improve patient outcome, we are performing a randomized controlled trial of the use of tranexamic acid (TXA) during acetabular fracture surgery. DESIGN: Prospective, multicenter, and randomized. SETTING: Two level I trauma centers. PARTICIPANTS: Eighty-eight patients underwent randomization, with 42 assigned to the TXA group and 46 assigned to the placebo group...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938282/efficacy-and-safety-of-tranexamic-acid-in-orthopaedic-fracture-surgery-a-meta-analysis-and-systematic-literature-review
#8
Kamil M Amer, Saqib Rehman, Kamal Amer, Christopher Haydel
BACKGROUND: Tranexamic acid (TXA) is an antifibrinolytic drug that has been shown to be effective in reducing blood loss and the need for transfusions after several orthopaedic surgeries. However, the effectiveness of TXA use in orthopaedic fracture surgeries still remains unclear. The purpose of this meta-analysis was to review existing literature with interest in the effectiveness and safety of TXA treatment in reducing total blood loss and transfusion rates for patients who underwent surgery for fracture repairs...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938281/tranexamic-acid-in-orthopaedic-trauma-surgery-a-meta-analysis
#9
Elizabeth B Gausden, Rameez Qudsi, Myles D Boone, Brian OʼGara, Joseph J Ruzbarsky, Dean G Lorich
AIM: To systematically review and quantify the efficacy of tranexamic acid (TXA) use in reducing the risk of receiving a blood transfusion in patients undergoing orthopaedic trauma surgery, in reducing blood loss, and risk of thromboembolic events. METHODS: A systematic literature search was performed using MEDLINE, Embase, ClinicalTrials.gov, and conference proceeding abstracts from 2014 to 2016. A minimum of 2 reviewers screened each study and graded quality. The primary outcome measure was the risk of receiving a blood transfusion in the TXA group versus control...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938035/guided-bone-regeneration-with-collagen-membranes-and-particulate-graft-materials-a-systematic-review-and-meta-analysis
#10
Bastian Wessing, Stefan Lettner, Werner Zechner
PURPOSE: The aim of this meta-analysis was to evaluate different methods for guided bone regeneration using collagen membranes and particulate grafting materials in implant dentistry. MATERIALS AND METHODS: An electronic database search and hand search were performed for all relevant articles dealing with guided bone regeneration in implant dentistry published between 1980 and 2014. Only randomized clinical trials and prospective controlled studies were included...
September 22, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28937978/a-new-discrete-dynamic-model-of-aba-induced-stomatal-closure-predicts-key-feedback-loops
#11
Réka Albert, Biswa R Acharya, Byeong Wook Jeon, Jorge G T Zañudo, Mengmeng Zhu, Karim Osman, Sarah M Assmann
Stomata, microscopic pores in leaf surfaces through which water loss and carbon dioxide uptake occur, are closed in response to drought by the phytohormone abscisic acid (ABA). This process is vital for drought tolerance and has been the topic of extensive experimental investigation in the last decades. Although a core signaling chain has been elucidated consisting of ABA binding to receptors, which alleviates negative regulation by protein phosphatases 2C (PP2Cs) of the protein kinase OPEN STOMATA 1 (OST1) and ultimately results in activation of anion channels, osmotic water loss, and stomatal closure, over 70 additional components have been identified, yet their relationships with each other and the core components are poorly elucidated...
September 22, 2017: PLoS Biology
https://www.readbyqxmd.com/read/28937904/periodontal-pathogen-colonization-in-young-children-by-pcr-quantification-a-longitudinal-survey
#12
Karine Takahashi, Robson Frederico Cunha, Elerson Gaetti Jardim Junior
INTRODUCTION: Periodontal diseases are among the leading causes of premature tooth loss in adults, but the microbiota associated with this problem is established over time in childhood. AIM: This longitudinal study aimed to verify the occurrence of periodontal pathogens in the oral cavity of children aged six, twelve, eighteen and twenty-four months through PCR quantification, correlating them with the oral microbiota of their mothers. STUDY DESIGN: Saliva and oral biofilm samples were collected from mothers and children by using sterilized paper points...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937456/is-1-stage-posterior-corpectomy-more-favorable-compared-with-decompression-with-fusion-to-control-thoracic-cord-compression-by-metastasis
#13
Dae Geun Kim, Jung-Ki Ha, Chang Ju Hwang, Dong-Ho Lee, Choon Sung Lee, Jae Hwan Cho
STUDY DESIGN: A retrospective comparative study OBJECTIVE:: To compare 1-stage posterior corpectomy to decompression with fusion for the control of thoracic cord compression due to a metastatic tumor. SUMMARY OF BACKGROUND DATA: Thoracic cord compression by a metastatic tumor can cause back pain, paralysis, and urinary/bowel dysfunction and is generally treated by palliative decompressive surgery. However, no studies have assessed the advantages of 1-stage posterior corpectomy compared with decompression with fusion...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937339/locked-out
#14
Veronica Johansson, Surjo R Soekadar, Jens Clausen
Brain-computer interfaces (BCIs) can enable communication for persons in severe paralysis including locked-in syndrome (LIS); that is, being unable to move or speak while aware. In cases of complete loss of muscle control, termed "complete locked-in syndrome," a BCI may be the only viable solution to restore communication. However, a widespread ignorance regarding quality of life in LIS, current BCIs, and their potential as an assistive technology for persons in LIS, needlessly causes a harmful situation for this cohort...
October 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28937286/comparing-subjective-and-objective-image-quality-at-two-different-radiation-exposure-ranges-of-the-paranasal-sinus-ct-examinations-using-a-volumetric-320-row-detector-ct-system
#15
Berhan Pirimoglu, Recep Sade, Muhammed Sedat Sakat, Hayri Ogul, Suat Eren, Mecit Kantarci
OBJECTIVES: To evaluate image quality of protocol including 135 kVp, 5 mAs and 80 kVp, 5 mAs in the paranasal sinus CT examinations using single volumetric 320-row multidetector CT technique. METHODS: From September to December 2016, both of our control group including 135 kVp and 5 mAs and our study group including 80 kVp and 5 mAs paranasal CT protocols were simultaneously performed on 40 patients using single volumetric 320-row multidetector CT device. Image quality for bony structures, air-filled structures and soft tissues were independently assessed for each group by three blinded observers using a 3-point grading scale (0 = not diagnostic, 1 = partially diagnostic, 2 = diagnostic)...
September 21, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28936871/effect-of-drying-moisture-exposed-almonds-on-the-development-of-the-quality-defect-concealed-damage
#16
Cristian Eduardo Rogel-Castillo, Kathleen K Luo, Guangwei Huang, Alyson Elayne Mitchell
Concealed damage (CD), is a term used by the nut industry to describe a brown discoloration of kernel nutmeat that becomes visible after moderate heat treatments (e.g. roasting). CD can result in consumer rejection and product loss. Postharvest exposure of almonds to moisture (e.g. rain) is a key factor in the development of CD as it promotes hydrolysis of proteins, carbohydrates and lipids. The effect of drying moisture-exposed almonds between 45°C - 95°C, prior to roasting was evaluated as a method for controlling CD in roasted almonds...
September 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28936585/understanding-intestinal-glucose-transporter-expression-in-obese-compared-to-non-obese-subjects
#17
Rebecca A Deal, Yueming Tang, Reid Fletcher, Alfonso Torquati, Philip Omotosho
INTRODUCTION: The impact of Roux-en-Y gastric bypass (RYGB) on weight loss and co-morbid disease resolution is well established. However, the mechanisms underlying the procedure remain incompletely understood. Intestinal remodeling involving glucose transporters (GLUTs) may play a crucial role. Rat studies have demonstrated morphological adaptation of GLUTs within adipose and intestinal cells in association with the reprogramming of glucose metabolism. There is a limited understanding of the variations in expression amongst GLUT family receptors in the human intestine...
September 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28936224/role-of-crrlk1l-cell-wall-sensors-hercules1-and-2-theseus1-and-feronia-in-growth-adaptation-triggered-by-heavy-metals-and-trace-elements
#18
Julia Richter, Marie Ploderer, Gaëlle Mongelard, Laurent Gutierrez, Marie-Theres Hauser
Cell walls are not only a protective barrier surrounding protoplasts but serve as signaling platform between the extracellular environment and the intracellular physiology. Ions of heavy metals and trace elements, summarized to metal ions, bind to cell wall components, trigger their modification and provoke growth responses. To examine if metal ions trigger cell wall sensing receptor like kinases (RLKs) of the Catharanthus roseus RLK1-like (CrRLK1L) family we employed a molecular genetic approach. Quantitative transcription analyses show that HERCULES1 (HERK1), THESEUS1 (THE1), and FERONIA (FER) were differently regulated by cadmium (Cd), nickel (Ni), and lead (Pb)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28936050/comparative-evaluation-of-corneal-endothelium-in-patients-with-diabetes-undergoing-phacoemulsification
#19
Pramod K Sahu, Gopal K Das, Sumeet Agrawal, Sabitabh Kumar
PURPOSE: The purpose of this study is to determine if phacoemulsification with posterior chamber foldable intraocular lens implantation has a greater impact on the corneal endothelium of type 2 diabetic patients as compared to nondiabetic controls. MATERIALS AND METHODS: This study compared the corneal endothelial status in sixty patients with diabetes with good glycemic control and sixty nondiabetic controls before and after (1 week, 1 month, 2 month, and 3 month) uneventful phacoemulsification...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28935987/toward-the-identification-of-a-type-i-toxin-antitoxin-system-in-the-plasmid-dna-of-dairy-lactobacillus-rhamnosus
#20
Claudia Folli, Alessia Levante, Riccardo Percudani, Davide Amidani, Stefania Bottazzi, Alberto Ferrari, Claudio Rivetti, Erasmo Neviani, Camilla Lazzi
Plasmids carry genes that give bacteria beneficial traits and allow them to survive in competitive environments. In many cases, they also harbor toxin-antitoxin (TA) systems necessary for plasmid maintenance. TA systems are generally characterized by a stable "toxin", a protein or peptide capable of killing the cell upon plasmid loss and by an unstable "antitoxin", a protein or a non-coding RNA that inhibits toxin activity. Here we report data toward the identification of a RNA-regulated TA system in the plasmid DNA of L...
September 21, 2017: Scientific Reports
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