Jingyan Guo, Linya You, Yu Zhou, Jiali Hu, Jiahao Li, Wanli Yang, Xuelin Tang, Yimin Sun, Yuqi Gu, Yi Dong, Xi Chen, Christine Sato, Lorne Zinman, Ekaterina Rogaeva, Jian Wang, Yan Chen, Ming Zhang
Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease with uncertain genetic predisposition in most sporadic cases. Spatial architecture of cell types and gene expression is the basis of cell-cell interactions, biological function and disease pathology, but is not well investigated in human motor cortex, a key ALS relevant brain region. Recent studies indicated single nucleus transcriptomic features of motor neuron vulnerability in ALS motor cortex. However, it remains largely unclear what is the brain regional vulnerability of ALS-associated genes, and what is the genetic link between region-specific genes and ALS risk...
April 20, 2024: Brain