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https://www.readbyqxmd.com/read/29352737/bronchiolitis-obliterans-syndrome-is-associated-with-increased-p-glycoprotein-expression-and-loss-of-glucocorticoid-receptor-from-steroid-resistant-pro-inflammatory-cd8-t-cells
#1
Greg Hodge, Sandra Hodge, Phan Tien Nguyen, Aeneas Yeo, Parama Sarkar, Arash Badiei, C L Holmes-Liew, Paul N Reynolds, Mark Holmes
Immunosuppressive therapy fails to suppress the production of pro-inflammatory cytokines, particularly by CD8+T cells, in stable lung transplant recipients and those undergoing chronic rejection, suggesting that some patients may become relatively resistant to immunosuppressants such as glucocorticoids (GC). We have shown loss of GC receptor (GCR) from the CD8+ cells, and we hypothesized that the drug membrane efflux pump, p-glycoprotein-1 (Pgp), may also be involved in lymphocyte steroid resistance following lung transplant...
January 20, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29352654/resistance-training-during-a-12-week-protein-supplemented-vlcd-treatment-enhances-weight-loss-outcomes-in-obese-patients
#2
Edward Jo, Phillip R Worts, Marcus L Elam, Ann Frost Brown, Andy V Khamoui, Do-Houn Kim, Ming-Chia Yeh, Michael J Ormsbee, Carla M Prado, Angelina Cain, Katie Snyder, Jeong-Su Kim
BACKGROUND: This investigation evaluated the efficacy by which resistance training enhances body composition, metabolic, and functional outcomes for obese patients undergoing a 12-week medically supervised hypocaloric treatment. METHODS: This was a single-blind, randomized, parallel-group prospective trial. Morbidly obese patients were prescribed a 12-week proprietary very low calorie diet (VLCD) treatment (Optifast®) with supplemental protein (1120 kcals/day) and were placed in one of two groups for 14 weeks: 1) Standard Treatment Control (CON) (n = 5) or 2) Resistance Training (RT) (n = 6)...
December 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29352599/-detection-of-chlamydia-abortus-in-bovine-reproductive-losses-in-the-province-of-la-pampa-argentina
#3
María Del C Rojas, Marcelo Fort, Simone Bettermann, Carolina Entrocassi, Sixto R Costamagna, Konrad Sachse, Marcelo Rodríguez Fermepin
Reproductive losses linked to an infectious etiology in bovine cattle are a major economic concern worldwide. In Argentina, more than 50% of abortion cases have unknown causes. Species belonging to Chlamydiaceae family are frequent etiologic agents of abortion around the world; however, there is yet no information on their prevalence in Argentina. The objective of this work was to identify Chlamydia spp., and particularly C. abortus in reproductive losses from bovine cattle in La Pampa, Argentina. Real time PCR targeting Chlamydiaceae-specific DNA fragments was performed on 251 samples obtained from bovine abortions and stillborns, and ArrayTube was used for species identification on positive samples...
January 16, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29352578/a-physiotherapist-led-exercise-and-education-program-for-preventing-recurrence-of-low-back-pain-a-randomised-controlled-pilot-trial
#4
Matthew L Stevens, Chung-Wei C Lin, Mark J Hancock, Trish Wisby-Roth, Jane Latimer, Chris G Maher
BACKGROUND: Before beginning a large and complex trial it is considered good practice to run a pilot study to assess the feasibility and acceptability so that quality is maintained and resources are not wasted. OBJECTIVE: To assesses the feasibility and acceptability of procedures for TOPS: Trial Of Prevention Strategies for low back pain. DESIGN: Randomised controlled pilot trial. METHODS: This is a trial of an 8 week, physiotherapist-led group exercise and education program for preventing recurrence of low back pain (LBP) in those recently recovered from LBP...
September 1, 2017: Physiotherapy
https://www.readbyqxmd.com/read/29352461/clinical-and-microbiological-evaluation-of-the-effect-of-lactobacillus-reuteri-in-the-treatment-of-mucositis-and-peri-implantitis-a-triple-blind-randomized-clinical-trial
#5
M Galofré, D Palao, M Vicario, J Nart, D Violant
BACKGROUND AND OBJECTIVE: Oral probiotics appear to improve the treatment of periodontal diseases but there is limited evidence on their efficacy in the treatment of peri-implant diseases. The objective of the present study was to evaluate, clinically and microbiologically, the effect of the oral probiotic, Lactobacillus reuteri Prodentis, as adjuvant to non-surgical mechanical therapy in implants with mucositis or peri-implantitis, placed in patients with a history of periodontal disease...
January 19, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29352337/impact-of-hepatitis-b-carrier-status-on-the-outcomes-of-surgical-treatment-of-colorectal-liver-metastases
#6
Kin Pan Au, Kenneth Siu Ho Chok, Albert Chi Yan Chan, Wing Chiu Dai, Tan To Cheung, Chung Mau Lo
BACKGROUND: Chronic hepatitis B virus (HBV) infection is associated with a lower incidence of colorectal liver metastases. We explored the impact of HBV carrier status on outcomes of surgical treatment of colorectal liver metastases. METHODS: A retrospective analysis was conducted for consecutive patients undergoing liver resection for colorectal liver metastases from 2000 to 2016. HBV carriers were matched with controls by propensity scoring. RESULTS: 304 patients with known HBV carrier status who underwent resection of colorectal liver metastases were studied...
January 19, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29352127/structural-covariance-of-gray-matter-volume-in-hiv-vertically-infected-adolescents
#7
Jielan Li, Lei Gao, Zhi Wen, Jing Zhang, Panying Wang, Ning Tu, Hao Lei, Fuchun Lin, Xi'en Gui, Guangyao Wu
Human immunodeficiency virus (HIV) infection significantly affect neurodevelopmental and behavioral outcomes. We investigated whether alterations of gray matter organization and structural covariance networks with vertical HIV infection adolescents exist, by using the GAT toolbox. MRI data were analysed from 25 HIV vertically infected adolescents and 33 HIV-exposed-uninfected control participants. The gray matter volume (GMV) was calculated, and structural brain networks were reconstructed from gray matter co-variance...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352064/gif-transcriptional-co-regulators-control-root-meristem-homeostasis
#8
María Florencia Ercoli, Antonella Ferela, Juan M Debernardi, Ana Paula Perrone, Ramiro E Rodriguez, Javier Fernando Palatnik
In the root meristem, the quiescent center (QC) is surrounded by stem cells, which in turn generate the different cell types of the root. QC cells rarely divide under normal conditions but can replenish damaged stem cells. In the proximal meristem, the daughters of stem cells, which are referred to as transit amplifying cells, undergo additional rounds of cell division prior to differentiation. Here, we describe the functions of GRF-INTERACTING FACTORs (GIFs), including ANGUSTIFOLIA3 (AN3), in Arabidopsis thaliana roots...
January 18, 2018: Plant Cell
https://www.readbyqxmd.com/read/29351881/phonotactic-processing-deficit-following-left-hemisphere-stroke
#9
Maryam Ghaleh, Laura M Skipper-Kallal, Shihui Xing, Elizabeth Lacey, Iain DeWitt, Andrew DeMarco, Peter Turkeltaub
The neural basis of speech processing is still a matter of great debate. Phonotactic knowledge-knowledge of the allowable sound combinations in a language-remains particularly understudied. The purpose of this study was to investigate the brain regions crucial to phonotactic knowledge in left-hemisphere stroke survivors. Results were compared to areas in which gray matter anatomy related to phonotactic knowledge in healthy controls. 44 patients with chronic left-hemisphere stroke, and 32 controls performed an English-likeness rating task on 60 auditory non-words of varying phonotactic regularities...
December 20, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29351814/setdb1-prevents-tet2-dependent-activation-of-iap-retroelements-in-na%C3%A3-ve-embryonic-stem-cells
#10
Özgen Deniz, Lorenzo de la Rica, Kevin C L Cheng, Dominik Spensberger, Miguel R Branco
BACKGROUND: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ERV repression in embryonic stem cells (ESCs), with DNA methylation also playing an important role. It has been suggested that SETDB1 protects ERVs from TET-dependent DNA demethylation, but the relevance of this mechanism for ERV expression remains unclear. Moreover, previous studies have been performed in primed ESCs, which are not epigenetically or transcriptionally representative of preimplantation embryos...
January 19, 2018: Genome Biology
https://www.readbyqxmd.com/read/29351770/-i-struggle-to-count-my-blessings-recovery-after-hip-fracture-from-the-patients-perspective
#11
Vigdis Bruun-Olsen, Astrid Bergland, Kristi Elisabeth Heiberg
BACKGROUND: Recovery outlooks of physical functioning and quality of life after hip fracture have not changed significantly over the past 25 years. Previous research has mainly dealt with causalities and acute treatment, while the recovery process from the patients' perspective has been less comprehensively described. Expanded knowledge of what the patients consider important in their recovery process may have important consequences for how these patients are treated in the future and thereby on future patient outcomes...
January 19, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29351580/maternal-nutrient-restriction-impairs-young-adult-offspring-ovarian-signaling-resulting-in-reproductive-dysfunction-and-follicle-loss
#12
K A Chan, P A Jazwiec, W Gohir, J J Petrik, D M Sloboda
Reproductive abnormalities are included as health complications in offspring exposed to poor prenatal nutrition. We have previously shown in a rodent model, that offspring born to nutrient restriction during pregnancy are born small, enter puberty early, and display characteristics of early ovarian aging as adults. The present study investigated whether key proteins involved in follicle recruitment and growth mediate ovarian follicle loss. Pregnant rats were randomized to: a standard diet throughout pregnancy and lactation (CON), or a calorie-restricted (50% of control) diet (UN) during pregnancy...
January 17, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29351490/significant-improvement-in-cardiometabolic-health-in-healthy-non-obese-individuals-during-caloric-restriction-induced-weight-loss-and-weight-loss-maintenance
#13
Jasper Most, L Anne Gilmore, Steven R Smith, Hongmei Han, Eric Ravussin, Leanne M Redman
Caloric restriction (CR) triggers benefits for healthspan including decreased risk of cardiometabolic disease. In an ancillary study to CALERIE 2, a 24-month 25% CR study, we assessed the cardiometabolic effects of CR in 53 non-obese (BMI: 22-28 kg/m2) men (n=17) and women (n=36). According to the energy-balance method (doubly labeled water and changes in body energy stores), the 25% CR intervention (n=34) produced 17{plus minus}1% (mean{plus minus}SE) and 14{plus minus}1% CR after 12 and 24 months (M12, M24), resulting in significant weight loss (M12: -9{plus minus}0...
December 12, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29351432/diurnal-pattern-in-skin-na-and-water-content-is-associated-with-salt-sensitive-hypertension-in-etb-receptor-deficient-rats
#14
Joshua S Speed, Kelly A Hyndman, Malgorzata Kasztan, Jermaine G Johnston, Kaehler J Roth, Jens M Titze, David M Pollock
Impairment in the ability of the skin to properly store Na+ non-osmotically (without water) has recently been hypothesized as contributing to salt-sensitive hypertension. Our lab has shown that endothelial production of endothelin-1 (ET-1) is crucial to skin Na+ handling. Further, it is well established that loss of ETB receptor function impairs Na+ excretion by the kidney. Thus we hypothesized that rats lacking functional ETB receptors (ETB def) will have a reduced capacity of the skin to store Na+ during chronic high salt (HS) intake...
December 13, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351429/removal-of-interscapular-brown-adipose-tissue-increases-aortic-stiffness-despite-normal-systemic-glucose-metabolism-in-mice
#15
Zachary Ian Grunewald, Nathan C Winn, Michelle L Gastecki, Makenzie L Woodford, James R Ball, Sarah A Hansen, Harold S Sacks, Victoria J Vieira-Potter, Jaume Padilla
Brown adipose tissue (BAT) is considered protective against obesity and related cardiometabolic dysfunction. Indeed, activation of BAT improves glucose homeostasis and attenuates cardiovascular disease development. However, whether a reduction in BAT mass perturbs metabolic function and increases risk for cardiovascular disease remains largely unknown. To address this question, C57BL/6J male mice underwent sham or surgical bilateral excision of interscapular BAT (iBATx) and were fed a normal chow or Western diet (WD) for 18 weeks, creating four groups (n=10/group)...
December 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351428/control-of-appetite-blood-glucose-and-blood-pressure-during-melanocortin-4-receptor-activation-in-normoglycemic-and-diabetic-npy-deficient-mice
#16
Alexandre A da Silva, John Nathan Freeman, John E Hall, Jussara M do Carmo
Although central melanocortin 4 receptor (MC4R) blockade abolishes the CNS-mediated anorexogenic, antidiabetic and cardiovascular actions of leptin, chronic MC4R stimulation fails to completely mimic leptin's effects. Because neuropeptide Y (NPY) and MC4R exert opposite effects on cardiovascular and metabolic functions, we tested its role in offsetting the long-term actions of MC4R activation. Wild-type (WT) and NPY-deficient (NPY-/-) mice were implanted with telemetry probes for measuring mean arterial pressure (MAP) and heart rate (HR) 24-h/d...
December 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351427/role-of-ptp1b-in-pomc-neurons-during-chronic-high-fat-diet-sex-differences-in-regulation-of-liver-lipids-and-glucose-tolerance
#17
Nicola Aberdein, Robert J Dambrino, Jussara M do Carmo, Zhen Wang, Laura E Mitchell, Heather A Drummond, John E Hall
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of leptin receptor signalling and may contribute to leptin resistance in diet-induced obesity. Although PTP1B inhibition has been suggested as a potential weight loss therapy, the role of specific neuronal PTP1B signalling in cardiovascular and metabolic regulation and the importance of sex differences in this regulation are still unclear. In this study, we investigated the impact of pro-opiomelanocortin (POMC) neuronal PTP1B deficiency in cardiometabolic regulation in male and female mice fed a high fat diet (HFD)...
December 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351316/dexmedetomidine-reduces-lipopolysaccharide-induced-neuroinflammation-sickness-behavior-and-anhedonia
#18
Ching-Hua Yeh, Liang-Po Hsieh, Ming-Chung Lin, Tsui-Shan Wei, Hui-Ching Lin, Chia-Cheng Chang, Chung-Hsi Hsing
BACKGROUND: Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)-induced neuroinflammation and sickness behavior in mice. MATERIALS AND METHODS: BALB/c mice were intraperitoneally (i.p.) injected with Dex (50 ug/kg) or vehicle. One hour later, the mice were injected (i...
2018: PloS One
https://www.readbyqxmd.com/read/29351294/a-had-family-phosphatase-csp-6-regulates-the-circadian-output-pathway-in-neurospora-crassa
#19
Xiaoying Zhou, Bin Wang, Jillian M Emerson, Carol S Ringelberg, Scott A Gerber, Jennifer J Loros, Jay C Dunlap
Circadian clocks are ubiquitous in eukaryotic organisms where they are used to anticipate regularly occurring diurnal and seasonal environmental changes. Nevertheless, little is known regarding pathways connecting the core clock to its output pathways. Here, we report that the HAD family phosphatase CSP-6 is required for overt circadian clock output but not for the core oscillation. The loss of function Δcsp-6 deletion mutant is overtly arrhythmic on race tubes under free running conditions; however, reporter assays confirm that the FREQUENCY-WHITE COLLAR COMPLEX core circadian oscillator is functional, indicating a discrete block between oscillator and output...
January 19, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29351277/ex-ante-assessment-of-different-vaccination-based-control-schedules-against-the-peste-des-petits-ruminants-virus-in-sub-saharan-africa
#20
Pachka Hammami, Renaud Lancelot, Joseph Domenech, Matthieu Lesnoff
BACKGROUND: Peste des petits ruminants (PPR) is a highly contagious and widespread viral infection of small ruminants (goats and sheep), causing heavy economic losses in many developing countries. Therefore, its progressive control and global eradication by 2030 was defined as a priority by international organizations addressing animal health. The control phase of the global strategy is based on mass vaccination of small ruminant populations in endemic regions or countries. It is estimated that a 70% post-vaccination immunity rate (PVIR) is needed in a given epidemiological unit to prevent PPR virus spread...
2018: PloS One
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