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tubercular meningitis

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https://www.readbyqxmd.com/read/27890955/aspergillus-meningoencephalitis-in-a-patient-with-human-immunodeficiency-virus-infection-normal-cerebrospinal-fluid-does-not-mean-absence-of-meningitis
#1
Soaham Dilip Desai, Sanket Seth, Aniketh Shah, Bhalendu Vaishnav
A male with human immunodeficiency virus infection presented with febrile encephalopathy followed by seizures and left hemiparesis. Initial imaging with contrast computerized tomography (CT) scan brain and cerebrospinal fluid (CSF) examination were normal. Subsequent magnetic resonance imaging brain revealed bilateral parieto-occipital infarcts with bleed. He did not improve on treatment with broad-spectrum antibiotics, anti-tubercular drugs, and antifungals. He finally succumbed to the disease. His CSF culture grew Aspergillus after 2 weeks...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27857783/hyponatremia-in-children-with-tuberculous-meningitis-a-hospital-based-cohort-study
#2
Prithi Inamdar, Sanjeevani Masavkar, Preeti Shanbag
BACKGROUND: Hyponatremia has long been recognized as a potentially serious metabolic consequence of tuberculous meningitis (TBM) occurring in 35-65% of children with the disease. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has for long been believed to be responsible for the majority of cases of hyponatremia in TBM. Cerebral salt wasting syndrome (CSWS) is being increasingly reported as a cause of hyponatremia in some of these children. AIM: This study was done to determine the frequency and causes of hyponatremia in children with TBM...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27728436/early-syringomyelia-in-tubercular-meningitis-a-rare-occurrence
#3
Amit Agarwal, Shilpa Avarebeel, Mohan Goudar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728426/a-study-on-cerebrospinal-fluid-adenosine-deaminase-level-in-tubercular-meningitis
#4
Tirthankar Roy, Kallol Bhattacharjee, Dwijen Das, A K Kalwar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728386/csf-lactate-as-prognostic-marker-in-tubercular-meningitis
#5
Vijay Singhal, Zeba Siddiqi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27727741/study-of-clinical-profile-of-tubercular-meningitis-in-hiv-positive-patients
#6
Puranik, R N, Umarji, P B
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27600423/-mri-features-of-ventricular-system-tuberculosis
#7
H X Mao, H Y Zhu, Y L Wang, Y Yang, X F You, X W Sun
OBJECTIVE: To study the MRI features of ventricular system tuberculosis. METHODS: Nineteen patients with ventricular system tuberculosis in our hospital from Mar. 2009 to Sep. 2014 were retrospectively identified. Their clinical features and cranial MRI characteristics were reviewed. RESULTS: There were 13 males and 6 females, aged from 15-81 years(mean 37±16). Eight patients had intraventricular tuberculosis, with 5 long striped or irregular shaped intraventricular tuberculosis and 3 with ventricular tuberculoma...
September 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27530874/partial-kluver-bucy-syndrome-secondary-to-tubercular-meningitis
#8
Kunal Kishor Jha, Satyajeet Kumar Singh, Prem Kumar, Charu Dutt Arora
Tubercular meningitis (TBM) is a devastating extra pulmonary manifestation of tuberculosis and demonstrates a high neurological morbidity. A rare complication of this condition is Kluver-Bucy syndrome (KBS), which is a neurobehavioral disorder characterised by hyper-sexuality, visual agnosia, bulimia, placidity, hyperorality and memory deficits caused by lesions to the amygdala. The amygdala lesions can be due to many causes, including traumatic brain injury, systemic conditions and infections such as tuberculosis...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27385155/adjunctive-role-of-mmp-9-inhibition-along-with-conventional-anti-tubercular-drugs-against-experimental-tuberculous-meningitis
#9
Shahnawaz Majeed, Bishan D Radotra, Sadhna Sharma
Tuberculous meningitis (TBM) is an outcome of neuroinflammatory degeneration caused due to Mycobacterium tuberculosis infection and leads to death or neurological disabilities in the affected individuals. It causes the highest morbidity and mortality amongst all forms of tuberculosis. Matrix metalloproteinase-9 levels increase and cause inflammatory destruction during progression of the disease. Although corticosteroids are usually given as an adjuvant therapy to overcome these complications, treatment outcome is contradictory...
June 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27365958/tubercular-meningitis-in-children-clinical-pathological-and-radiological-profile-and-factors-associated-with-mortality
#10
Anil V Israni, Divya A Dave, Anirban Mandal, Amitabh Singh, Puneet K Sahi, Rashmi Ranjan Das, Arpita Shah
CONTEXT: Childhood tuberculosis is a major public health problem in developing countries with tubercular meningitis being a serious complication with high mortality and morbidity. AIM: To study the clinicopathological as well as radiological profile of childhood tuberculous meningitis (TBM) cases. SETTINGS AND DESIGN: Prospective, observational study including children <14 years of age with TBM admitted in a tertiary care hospital from Western India...
July 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/27195031/outcome-of-ventriculoperitoneal-shunt-surgery-without-prior-placement-of-external-ventricular-drain-in-grades-iii-and-iv-patients-of-tubercular-meningitis-with-hydrocephalus-a-single-institution-s-experience-in-the-pediatric-population-and-review-of-literature
#11
Vivek Kumar Kankane, Tarun Kumar Gupta, Gaurav Jaiswal
OBJECTIVE: Hydrocephalus is a most common complication of tubercular meningitis (TBM). Relieving hydrocephalus by ventriculoperitoneal shunt (VPS) placement has been considered beneficial in patient in Palur Grades II or III. The role of VPS placement in those of Grades III and IV is controversial, and general tendency is to avoid its use. Some authors have suggested that patient in Grades III and IV should receive a shunt only if their condition improves with a trial placement of external ventricular drain (EVD)...
January 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27190411/clinical-manifestations-and-outcome-of-patients-with-human-immunodeficiency-virus-infection-at-tertiary-care-teaching-hospital
#12
Virendra Chandrashekhar Patil, Harsha V Patil
BACKGROUND: AIDS has become chronic illness which is well treated with antiretroviral therapy and management of opportunistic infections (OIs). AIMS AND OBJECTIVES: The study clinical profile and outcome of human immunodeficiency virus (HIV) seropositive patients. MATERIALS AND METHODS: This was retrospective observational study carried out over a period of 1 year (January 2011-December 2011). All HIV patients admitted in medicine ward, and ICU were enrolled...
January 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27160122/mir-221-and-mir-222-simultaneously-target-arid1a-and-enhance-proliferation-and-invasion-of-cervical-cancer-cells
#13
Y Yang, X Zhao, H-X Li
OBJECTIVE: To explore the expression level of neuron-specific enolase (NSE), S100B and neuropeptide Y (NPY) in children with acute miliary tuberculosis and secondary tubercular meningitis. PATIENTS AND METHODS: 28 children diagnosed with acute miliary tuberculosis and secondary tubercular meningitis were included into group A, 25 children diagnosed with pure acute miliary tuberculosis were included into group B and 23 children diagnosed with suspected meningitis were included into group C...
April 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27160117/expression-level-of-nse-s100b-and-npy-in-children-with-acute-miliary-phthisis-and-secondary-tubercular-meningitis
#14
C-X Zhang, D-J Zhang, Y-L Wang, W Han, G-C Shi, H-Q Zhang
OBJECTIVE: To explore the expression level of neuron-specific enolase (NSE), S100B and neuropeptide Y (NPY) in children with acute miliary tuberculosis and secondary tubercular meningitis. PATIENTS AND METHODS: 28 children diagnosed with acute miliary tuberculosis and secondary tubercular meningitis were included into group A, 25 children diagnosed with pure acute miliary tuberculosis were included into group B and 23 children diagnosed with suspected meningitis were included into group C...
April 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27053183/genexpert-for-diagnosis-of-tubercular-meningitis
#15
Rakesh Bhatia, Rajeshwar Dayal, Shishir Jindal, Dipti Agarwal, Ankur Goyal
Diagnosis of tubercular meningitis (TBM) is difficult in children. The GeneXpert MTB/RIF assay has been recommended by WHO in 2013 to be used in children and in extra pulmonary clinical specimens. The present study was designed to assess the diagnostic utility of GeneXpert in detecting Mycobacterium tuberculosis in cerebrospinal fluid (CSF) in TBM cases and to compare the results with liquid culture BACTEC 460. Thirty four subjects <15 y were diagnosed as TBM based on clinical, CSF and imaging details. Sensitivity of GeneXpert in CSF was 38...
November 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/26816960/thrombocytopenia-in-paediatric-icu-incidence-transfusion-requirement-and-role-as-prognostic-indicator
#16
Amarpreet Kaur, Gurmeet Kaur Sethi, Ram Kumar Goyal, Avneet Kaur, Rupinderjeet Kaur, Shashi Kant Dhir, Harshvardhan Gupta
INTRODUCTION: Thrombocytopenia is defined as platelet count less than 150×10(9)/L, it has a greater incidence in Intensive Care Units (ICUs) compared to wards and its most common cause is increased platelet consumption. AIMS: To investigate incidence of thrombocytopenia, platelet transfusions requirement, associated diseases and relationship between thrombocytopenia and mortality. MATERIALS AND METHODS: Eleven months hospital records between October 2013 and August 2014 of the PICU in a tertiary care teaching hospital was investigated retrospectively and 275 critically ill children formed the sample...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26628830/a-rare-case-of-idiopathic-cluster-of-differentiation-4-t-cell-lymphocytopenia-presenting-with-disseminated-tubercular-infection
#17
Vikas Sikri, Harpreet Kaur, Alok Jain
Idiopathic cluster of differentiation 4(+) (CD4(+)) T-cell lymphocytopenia is a rare heterogeneous clinical syndrome characterized by low absolute CD4 counts on two different occasions without any evidence of other known cause of immunodeficiency including human immunodeficiency virus (HIV), infections or drugs associated with fall in CD4(+) count. Also referred to as severe unexplained HIV seronegative immune suppression by the World Health Organization, it was first described by Centers for Disease Control in 1992 in patients with opportunistic infections who were negative for HIV but had low CD4 counts...
October 2015: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/26614185/magnetic-resonance-angiography-manifestations-and-prognostic-significance-in-hiv-negative-tuberculosis-meningitis
#18
T-T Lu, X-Q Lin, L Zhang, W Cai, Y-Q Dai, Z-Z Lu, A-M Wu, J Bao, Y Yang, X-Q Hu, Z-Q Lu
OBJECTIVE: To evaluate the patterns, related factors and prognostic value of abnormal magnetic resonance angiography (MRA) in human immunodeficiency virus negative tuberculous meningitis. MATERIALS AND METHODS: We performed a prospective study in patients aged >14 years. Abnormality on MRA was correlated with clinical, laboratory and magnetic resonance imaging findings. Modified Barthel index was used to assess outcome at 6 months after inclusion. RESULTS: Of 101 patients included, MRA was abnormal in 45 (44...
December 2015: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/26557587/acute-hypercalcaemia-and-hypervitaminosis-d-in-an-infant-with-extra-pulmonary-tuberculosis
#19
Devi Dayal, Siya Ram Didel, Sikha Agarwal, Naresh Sachdeva, Meenu Singh
In patients with tuberculosis, abnormal extrarenal production of 1,25-dihydroxyvitamin D3 by activated macrophages in granulomatous tissues may result in hypercalcaemia. More commonly reported in adults with active pulmonary tuberculosis, this complication may rarely occur in extrapulmonary tuberculosis, and children. The hypercalcaemia may be precipitated by usually recommended vitamin D and calcium supplementation in patients with tuberculosis. We report here an infant with tubercular meningitis who developed hypercalcaemia 12 days after starting routine vitamin D and calcium supplementation...
October 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26264947/treatment-for-tuberculosis-in-a-patient-with-dubin-johnson-syndrome
#20
Meena Alpana, Mradul Kumar Daga, Sunita Aggarwal, Anand Nidhi
Dubin-Johnson syndrome (DJS) is an autosomal recessive disorder characterised by conjugated hyperbilirubinemia resulting from mutations of ABCC2/MRP2 gene. The beneficial effects of ursodeoxycholic acid (UDCA) and rifampicin were found to be complementary in the treatment of cholestatic liver disease secondary to DJS. We present a case of a young woman with tubercular meningitis. She was started on modified antitubercular therapy in view of conjugated hyperbilirubinemia. However, reinitiation of rifampicin resulted in redevelopment of jaundice...
2015: BMJ Case Reports
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