keyword
https://read.qxmd.com/read/37929953/paraneoplasic-beh%C3%A3-et-s-syndrome-associated-with-chronic-myeloid-leukemia
#1
JOURNAL ARTICLE
Marta Moreira, Isabel Tarrio, Alda João Andrade, Luís Lopes
A 49-year-old man presented with a three-week history of abdominal pain, bloody diarrhoea and fever. Reported oral ulcers, weight loss and asthenia, as well as papulo-pustular lesions on his limbs and a recurrent ulcer in the lip (Fig.1) in the previous year. During hospitalization, he developed pathergy at venipuncture sites and painful scrotum ulcers. Laboratory showed pancytopenia and elevated CRP. Viral and autoimmune tests were negative. Abdominal CT revealed thickening of the ileocecal region with adenopathies...
November 6, 2023: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/37228962/antineuronal-autoantibodies-induced-paraneoplasic-syndrome-in-schizophrenia-spectrum-disorders-case-report
#2
JOURNAL ARTICLE
Fares Jaballah, Nouha Ben Hamed, Sayma Hamzaoui, Mohamed A Ayadi, Yosra Zgueb, Rabaa Jomli
UNLABELLED: Secondary psychiatric symptoms are usually suspected when there is an atypical presentation of the symptoms or a lack of response to psychotropic medication. CASE PRESENTATION: Our case is about a woman aged 62 years old, with a history of mental disorder who presented psychiatric symptomatology after years of being stabilized by antipsychotics. She was later investigated due to a mass in her breast. Carcinoma was diagnosed, and her psychiatric symptomatology was resolved after the tumerectomy...
May 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/33682384/-bilateral-diffuse-uveal-melanocytic-proliferation-a-rare-paraneoplasic-syndrome-to-be-diagnosed-early
#3
A S Roblain, D Malaise, G Lepièce, B Locht, J M Rakic
Diffuse bilateral uveal melanocytic proliferation is a rare paraneoplastic ophthalmologic syndrome. The increase in life expectancy in oncology partly explains the gradual increase in its incidence. In almost half of the cases, the syndrome manifests itself before the diagnosis of primary neoplasia. It should be suspected in cases of bilateral uveal pigmented lesions that do not meet the clinical criteria for other known eye pathologies. Legal blindness occurs for the majority of patients during the first year after the initial clinical presentation...
March 2021: Revue Médicale de Liège
https://read.qxmd.com/read/31564378/-malignant-acanthosis-nigricans-associated-with-cholangiocarcinoma
#4
JOURNAL ARTICLE
A Roser, C Pajot, S Kettani, S Michalak, C Le Clech
INTRODUCTION: Acanthosis nigricans is a dermatosis characterized by the presence of a hyperpigmented, velvety cutaneous thickening in the flexural areas, especially axillary and inguinal fossas, and lateral faces of the neck. AN is usually a benign condition but can sometimes reveal an internal malignancy corresponds to a cutaneous paraneoplasic syndrome. Literature shows a predominant association with gastric adenocarcinoma. Here, we report a rare association between AN and cholangiocarcinoma...
November 2019: La Revue de Médecine Interne
https://read.qxmd.com/read/29426627/-interstitial-lung-diseases-from-autoimmune-origins-a-prognostic-and-diagnostic-challenge-for-the-clinician
#5
JOURNAL ARTICLE
O Pelton, G Chatte
Acute or subacute interstitial lung diseases from autoimmune origins are especially hard to diagnose but have to be detected promptly. We illustrate this necessity with three case reports. One case of paraneoplasic polymyositis, one case of interstitial lung disease caused by a connectivite and one case of interstitial lung disease related to an anti-synthetase syndrome. The subject is to alert the practitioners to the early search of extra pulmonary signs, autoantibodies analysis in the objective to set up quickly the right treatment...
April 2018: Revue de Pneumologie Clinique
https://read.qxmd.com/read/29340740/-paraneoplastic-syndromes-in-rheumatology
#6
REVIEW
J Leipe, H Schulze-Koops
Malignancies can present as inflammatory rheumatic diseases. These rheumatic paraneoplastic syndromes are rare, but characteristic in their pattern. This article focuses on epidemiology, clinical and diagnostic features as well as treatment of paraneoplasic rheumatic diseases such as paraneoplastic arthritides, vasculitides, myositis and hypertrophic osteoarthropathy. The knowledge of their clinical patterns is of utmost importance for early diagnosis and prognosis of yet undiagnosed malignancies.
February 2018: Der Internist
https://read.qxmd.com/read/27602070/high-dose-rate-intraluminal-brachytherapy-for-paraneoplastic-autoimmune-multiorgan-syndrome
#7
JOURNAL ARTICLE
Sun-Young Lee, Jong-Hyun Kim, Dong-Hyu Cho
Paraneoplastic autoimmune multiorgan syndrome (PAMS), also known as paraneoplasic pemphigus, involves the skin, internal organs and mucosa. PAMS-associated mortality may occur as a result of autoantibody formation against internal tumors and their infiltration into organs other than the skin lesions that characterize PAMS. The most common symptoms of PAMS include pain associated with continuous oral ulceration and resistance to pharmacological treatment. The present study reports the case of a 42-year-old female patient who was admitted with an 8-month history of erosive skin lesions within the trunk region, oral mucosa and vaginal mucosa...
September 2016: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/26877517/p-205-nephrotic-syndrome-revealing-hodgkin-s-disease
#8
JOURNAL ARTICLE
S Toujani, F Daoud, Z Aydi, L Baili, B Ben Dhaou, F Boussema
OBJECTIFS: The association between paraneoplasic nephrotic syndrome and Hodgkin's disease is rare estimated to be about 0.5 to 1% (0.4% as minimal change disease and 0.1% as amyloid). MéTHODES: We report the case of an Hodgkin's disease revealed by an isolated nephrotic syndrome. RéSULTATS: A 34-year-old man presented with the clinical symptoms of nephrotic syndrome, Physical examination was notable for lower extremity edema. Though his hematologic evaluation was consistent with anemia (white blood cells = 11300/mm(3); hemoglobin, 7,9g/dL; platelets, 482000/mm(3)), there was no evidence of hemolysis but a biologic inflammatory syndrome...
December 2015: Annales de Cardiologie et D'angéiologie
https://read.qxmd.com/read/26777972/cyclooxygenase-2-expression-in-non-small-cell-lung-cancer-correlates-with-hypertrophic-osteoarthropathy
#9
JOURNAL ARTICLE
Ioannis Rotas, Giovanni Cito, Igor Letovanec, Michel Christodoulou, Jean Y Perentes
Hypertrophic osteoarthrpathy (HO) is a rare paraneoplasic syndrome associated with non-small cell lung cancer (NSCLC). The pathophysiology of HO is unknown but was recently related to enhanced levels of urine prostaglandin E2 (PGE2). Here, we report the case of a patient that presented HO in association with a resectable left upper lobe NSCLC. Following surgery and adjuvant chemotherapy, HO resolved and did not recur with development of a brain metastasis 1 year later. Interestingly, tumor cyclooxygenase-2, an enzyme responsible the synthesis of PGE2, was expressed in the primary tumor but not in the resected metastasis...
February 2016: Annals of Thoracic Surgery
https://read.qxmd.com/read/26279697/ga68-dota-peptide-pet-ct-to-detect-occult-mesenchymal-tumor-inducing-osteomalacia-a-case-series-of-three-patients
#10
JOURNAL ARTICLE
Chi Long Ho
Tumor-induced osteomalacia (TIO) is a rare disease that manifests with paraneoplasic syndrome and overproduction of fibroblast growth factor 23 (FGF23), leading to renal phosphate wasting and hyperphosphaturia, eventually leading to acquired hypophosphatemic osteomalacia. Diagnosis of this disease is often challenging because of the small size of the lesion, which can be localized in bone or soft tissue anywhere in the body. Detecting these occult mesenchymal tumors (OMT) is of great importance as they are potentially curable after tumor resection...
September 2015: Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/23999024/-necrotizing-autoimmune-myopathies
#11
JOURNAL ARTICLE
P Petiot, A Choumert, L Hamelin, P Devic, N Streichenberger
Necrotizing autoimmune myopathies are included in the spectrum of inflammatory myopathies, together with polymyosis, dermatopolymyosis and inclusion body myositis, despite the characteristic feature of marked muscular necrosis without inflammatory infiltrates. The clinical presentation is highly variable, often similar to the other inflammatory myopathies. The most common finding is nevertheless the severe form with rhabdomyolysis. The creatine kinase level is elevated (around 10,000IU/l) and electromyography shows myopathic changes with increased spontaneous activities reflecting the importance of the muscular necrosis...
2013: Revue Neurologique
https://read.qxmd.com/read/23879060/-myocardial-infarction-in-colon-cancer
#12
JOURNAL ARTICLE
O M Lazutina, L I Markova, O L Belaia, A B Bezprozvannyĭ, V V Variasin, A E Radzevich
Paraneoplastic syndromes have a variety of clinical manifestations most frequently resembling systemic diseases and phlebothrombosis. Also, hypercoagulative paraneoplasic syndrome may have some clinical features of myocardial infarction which makes difficult nosological diagnostics.
2013: Klinicheskaia Meditsina
https://read.qxmd.com/read/22123569/-hodgkin-s-disease-revealed-by-a-nephrotic-syndrome-a-case-report-with-literature-review
#13
REVIEW
Hatim Nafil, Illias Tazi, Lahoucine Mahmal
The association between paraneoplasic nephrotic syndrome and Hodgkin's disease is rare. We report a case of Hodgkin's lymphoma in a young female patient with nephrotic syndrome. A 40-year-old woman presented with the clinical symptoms of nephrotic syndrome, kidney biopsy revealed minimal change glomerulonephritis. A treatment with prednisone was started but the response was partial. Twenty-four months after the diagnostic of nephrotic syndrome was made, she presented prolonged fever and weight loss, the physical examination showed cervical lymphadenopathy, which lymph node biopsy revealed Hodgkin lymphoma of the nodular sclerosing type...
November 2011: Annales de Biologie Clinique
https://read.qxmd.com/read/21441056/crusted-norwegian-scabies-an-opportunistic-infection-with-tocilizumab-in-rheumatoid-arthritis
#14
JOURNAL ARTICLE
Khadija Baccouche, Jérémie Sellam, Sarah Guegan, Sélim Aractingi, Francis Berenbaum
BACKGROUND: Crusted Norwegian scabies is an extremely rare hyperkeratotic variant of scabies infestation. We report herein a case of crusted scabies in a woman with severe rheumatoid arthritis (RA) treated by tocilizumab (TCZ), a monoclonal antibody blocking the interleukin-6 receptor. OBSERVATION: An 80-year-old female with severe RA developed erythroderma followed by hyperkeratosis, widespread scaling over the trunk, arms, hands and limbs, and crusted lesions on her scalp...
July 2011: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/19578602/tumor-induced-osteomalacia-a-case-report
#15
JOURNAL ARTICLE
Daniel Dutra Romualdo-Silva, Bárbara Campolina Carvalho Silva, Cristiane Vasconcelos Caetano, Angélica Maria França Paiva Tibúrcio, Maurício Buzelin Nunes, Sérgio Almeida Pinheiro Chagas, Elizandra Tomazela Laurenti Polito, Antônio Rodrigues Ferreira, Saulo Purisch
Tumor-induced osteomalacia (TIO) is a rare paraneoplasic syndrome with overproduction of fibroblast growth factor 23 as a phosphaturic agent, leading to chronic hyperphosphaturia and hypophosphatemia, associated with inappropriately normal or low levels of 1,25-dihydroxyvitamin D. Diagnosis of this disease is often challenging. The following case report described a middle-aged man with symptoms of bone pain and severe muscle weakness, who was found to have TIO. The tumor responsible for the symptoms was localized on his thigh and its resection resulted in normalization of blood chemistry and complaints...
April 2009: Arquivos Brasileiros de Endocrinologia e Metabologia
https://read.qxmd.com/read/18653203/-kleine-levin-syndrome-state-of-the-art
#16
REVIEW
I Arnulf, M Lecendreux, P Franco, Y Dauvilliers
INTRODUCTION: Kleine-Levin syndrome is a rare neurological disorder (1-2 cases per million inhabitants) primarily affecting young subjects. It is characterized by relapsing-remitting episodes of hypersomnia in association with cognitive and behavioral disturbances. Case-reports, small series, meta-analysis and a recent large, prospective trio study are consistent with a homogeneous, genuine disease entity. STATE OF THE ART: Patients are mostly male (68-78%) and adolescents (81%), with mean onset at 15 years (range 4-82 years)...
August 2008: Revue Neurologique
https://read.qxmd.com/read/18383907/uncommon-epiloptogenic-lesions-affecting-the-temporal-lobe
#17
REVIEW
Ana Ramos, Federico Ballenilla, Patricia Martin
There are several processes implicated as uncommon causes of temporal lobe epilepsy. Trauma is the leading cause of epilepsy in young adults, intracerebral blood collection being the most consistent risk factor of seizures, especially subdural hematomas and brain contusions. Infarction is the entity most commonly related to epilepsy in the elderly population. Seizures usually present as complex seizures with high recurrence between 6 months and 2 years after stroke. There are some radiological characteristics of the affectation associated with high risk of early and late seizures...
February 2008: Seminars in Ultrasound, CT, and MR
https://read.qxmd.com/read/18355470/-neurogenic-electromyographic-activity-in-a-patient-with-non-paraneoplasic-lambert-eaton-syndrome
#18
JOURNAL ARTICLE
B Lapergue, J-P Lefaucheur, A Bourahoui, T Nordine, H Hosseini, A Créange
INTRODUCTION: Lambert-Eaton myasthenic syndrome (LEMS) is a rare presynaptic disorder of the neuromuscular junction. Electrodiagnosis is characterized by compound muscle action potentials of small amplitude at rest, normalizing immediately after brief exercise or high-rate nerve stimulation. Needle electromyographic (EMG) activity is classically described as normal or myogenic. CASE: We report the case of a young patient with a non-paraneoplastic LEMS in whom the initial electroneuromyographic examination showed neurogenic changes in needle EMG concomitant with typical features of presynaptic neuromuscular junction disorder at single and repetitive nerve stimulation...
December 2007: Revue Neurologique
https://read.qxmd.com/read/18351188/-colorectal-epidermoid-carcinoma-and-paraneoplastic-hypercalcemia
#19
JOURNAL ARTICLE
J Gatlez, A Hendlisz, H Legendre, N Sirtaine, S Debroux, A Awada
The squamous cell carcinoma and the adenosquamous cell carcinoma of the colon and rectum are not well know and rare tumours. We report a case of squamous cell carcinoma of the recto-sigmoid who relapses in the liver after surgery of the primary tumour with paraneoplasic hypercalcaemia. We will discuss the pathogenesis, prognosis, associated conditions, clinical features and treatment strategies of squamous and adenosquamous cell carcinoma of the colon and the rectum.
November 2007: Acta Clinica Belgica
https://read.qxmd.com/read/18341977/-long-term-evolution-of-achalasia-of-the-lower-esophageal-sphincter-and-intestinal-paraneoplasic-pseudo-obstruction-revealing-small-cell-lung-carcinoma
#20
JOURNAL ARTICLE
N Ceze, L D'Alteroche, L Picon, P Magro, C Monégier du Sorbier, E-H Metman
We report a case of a small cell carcinoma of the lung revealed by chronic intestinal pseudo-obstruction associated with achalasia of the lower esophageal sphincter. Tumoral remission was achieved for more than 21 months after chemoradiotherapy but this did not prevent the paraneoplasic syndrome from persisting and medical treatment was not successful in treating the intestinal pseudo-obstruction or the dysphagia, which was not improved by esophageal dilation.
January 2008: Gastroentérologie Clinique et Biologique
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