Daniel Dutra Romualdo-Silva, Bárbara Campolina Carvalho Silva, Cristiane Vasconcelos Caetano, Angélica Maria França Paiva Tibúrcio, Maurício Buzelin Nunes, Sérgio Almeida Pinheiro Chagas, Elizandra Tomazela Laurenti Polito, Antônio Rodrigues Ferreira, Saulo Purisch
Tumor-induced osteomalacia (TIO) is a rare paraneoplasic syndrome with overproduction of fibroblast growth factor 23 as a phosphaturic agent, leading to chronic hyperphosphaturia and hypophosphatemia, associated with inappropriately normal or low levels of 1,25-dihydroxyvitamin D. Diagnosis of this disease is often challenging. The following case report described a middle-aged man with symptoms of bone pain and severe muscle weakness, who was found to have TIO. The tumor responsible for the symptoms was localized on his thigh and its resection resulted in normalization of blood chemistry and complaints...
April 2009: Arquivos Brasileiros de Endocrinologia e Metabologia