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https://www.readbyqxmd.com/read/28549078/herod-a-human-ethnic-and-regional-specific-omics-database
#1
Xian Zeng, Lin Tao, Zhang Peng, Chu Qin, Shangying Chen, Weidong He, Ying Tan, Hong Xia Liu, Sheng Yong Yang, Zhe Chen, Yu Yang Jiang, Yu Zong Chen
Motivation: Genetic and gene expression variations within and between populations and across geographical regions have substantial effects on the biological phenotypes, diseases, and therapeutic response. The development of precision medicines can be facilitated by the OMICS studies of the patients of specific ethnicity and geographic region. However, there is an inadequate facility for broadly and conveniently accessing the ethnic and regional specific OMICS data. Results: Here, we introduced a new free database, HEROD, a human ethnic and regional specific OMICS database...
May 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28544011/changing-trends-in-the-use-of-kratom-mitragyna-speciosa-in-southeast-asia
#2
Darshan Singh, Suresh Narayanan, Balasingam Vicknasingam, Ornella Corazza, Rita Santacroce, Andres Roman-Urrestarazu
OBJECTIVE: Kratom (Mitragyna speciosa. Korth) is an indigenous medicinal plant of Southeast Asia. This review paper aims to describe the trends of kratom use in Southeast Asia. DESIGN: A literature review search was conducted through ScienceDirect, Scopus, ProMed and Google Scholar. Twenty-five articles illustrating kratom use in humans in Southeast Asia were reviewed. RESULTS: Kratom has long been used by rural populations in Southeast Asia as a remedy for common ailments, to fight fatigue from hard manual work, as a drink during social interaction among men, and in village religious functions...
May 24, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28543372/hematologic-and-biochemical-ris-for-an-aged-population-of-captive-african-green-monkeys-chlorocebus-aethiops-sabaeus
#3
Elizabeth M Scallan, Saundra H Sample, Amy M Beierschmitt, Roberta M Palmour
BACKGROUND: Established RIs for geriatric African Green monkeys (Chlorocebus aethiops sabaeus) are critical for clinical differentiation of normal aging from disease-related changes in this population. OBJECTIVE: The aim of this study was to establish hematologic and serum biochemical RIs for a Caribbean captive population of geriatric (≥ 15 years of age) African Green monkeys, or Vervets. METHODS: Inclusion and exclusion criteria were defined for a cohort of 109 healthy, aged (15- to 30-year-old, median 19-year-old) Vervets...
May 19, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28533634/estimation-of-whole-body-radiation-exposure-to-nuclear-medicine-personnel-during-synthesis-of-177-lutetium-labeled-radiopharmaceuticals
#4
Geetanjali Arora, Rajesh Mishra, Praveen Kumar, Madhav Yadav, Sanjana Ballal, Chandrasekhar Bal, Nishikant Avinash Damle
PURPOSE OF THE STUDY: With rapid development in the field of nuclear medicine therapy, radiation safety of the personnel involved in synthesis of radiopharmaceuticals has become imperative. Few studies have been done on estimating the radiation exposure of personnel involved in the radio labeling of (177)Lu-compounds in western countries. However, data from the Indian subcontinent are limited. We have estimated whole body radiation exposure to the radiopharmacist involved in the labeling of: (177)Lu-DOTATATE, (177)Lu-PSMA-617, and (177)Lu-EDTMP...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28532888/biological-effects-of-direct-and-indirect-manipulation-of-the-fascial-system-narrative-review
#5
Giovanni Parravicini, Andrea Bergna
INTRODUCTION: Osteopathic Manipulative Treatment (OMT) is effective in improving function, movement and restoring pain conditions. Despite clinical results, the mechanisms of how OMT achieves its' effects remain unclear. The fascial system is described as a tensional network that envelops the human body. Direct or indirect manipulations of the fascial system are a distinctive part of OMT. OBJECTIVE: This review describes the biological effects of direct and indirect manipulation of the fascial system...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28531319/improved-sperm-kinematics-in-semen-samples-collected-after-2-h-versus-4-7-days-of-ejaculation-abstinence
#6
H Alipour, G Van Der Horst, O B Christiansen, F Dardmeh, N Jørgensen, H I Nielsen, C Hnida
STUDY QUESTION: Does a short abstinence period of only 2 h yield spermatozoa with better motility characteristics than samples collected after 4-7 days? SUMMARY ANSWER: Despite lower semen volume, sperm concentration, total sperm counts and total motile counts, higher percentages of motile spermatozoa with higher velocity and progressiveness were detected in samples obtained after 2 h. WHAT IS KNOWN ALREADY: Most studies that have assessed the effect of abstinence periods on sperm motility parameters in men with a sperm concentration below 15 million/ml have detected a higher percentage of motile spermatozoa in samples obtained after short abstinence periods...
May 22, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28526675/iterative-user-interface-design-for-automated-sequential-organ-failure-assessment-score-calculator-in-sepsis-detection
#7
Christopher Ansel Aakre, Jaben E Kitson, Man Li, Vitaly Herasevich
BACKGROUND: The new sepsis definition has increased the need for frequent sequential organ failure assessment (SOFA) score recalculation and the clerical burden of information retrieval makes this score ideal for automated calculation. OBJECTIVE: The aim of this study was to (1) estimate the clerical workload of manual SOFA score calculation through a time-motion analysis and (2) describe a user-centered design process for an electronic medical record (EMR) integrated, automated SOFA score calculator with subsequent usability evaluation study...
May 18, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28525668/comparison-of-hand-and-semiautomatic-tracing-methods-for-creating-maxillofacial-artificial-organs-using-sequences-of-computed-tomography-ct-and-cone-beam-computed-tomography-cbct-images
#8
Bence T Szabo, Seçil Aksoy, Gabor Repassy, Krisztian Csomo, Csaba Dobo-Nagy, Kaan Orhan
INTRODUCTION: The aim of this study was to compare the paranasal sinus volumes obtained by manual and semiautomatic imaging software programs using both CT and CBCT imaging. METHODS: 121 computed tomography (CT) and 119 cone beam computed tomography (CBCT) examinations were selected from the databases of the authors' institutes. The Digital Imaging and Communications in Medicine (DICOM) images were imported into 3-dimensonal imaging software, in which hand mode and semiautomatic tracing methods were used to measure the volumes of both maxillary sinuses and the sphenoid sinus...
May 17, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28523381/national-clinical-guidelines-for-non-surgical-treatment-of-patients-with-recent-onset-neck-pain-or-cervical-radiculopathy
#9
REVIEW
Per Kjaer, Alice Kongsted, Jan Hartvigsen, Alexander Isenberg-Jørgensen, Berit Schiøttz-Christensen, Bolette Søborg, Charlotte Krog, Christian Martin Møller, Christine Marie Bækø Halling, Henrik Hein Lauridsen, Inge Ris Hansen, Jesper Nørregaard, Karsten Juhl Jørgensen, Lars Valentin Hansen, Marie Jakobsen, Martin Bach Jensen, Martin Melbye, Peter Duel, Steffan W Christensen, Tina Myung Povlsen
PURPOSE: To summarise recommendations about 21 selected non-surgical interventions for recent onset (<12 weeks) non-specific neck pain (NP) and cervical radiculopathy (CR) based on two guidelines from the Danish Health Authority. METHODS: Two multidisciplinary working groups formulated recommendations based on the GRADE approach. RESULTS: Twelve recommendations were based on evidence and nine on consensus. Management should include information about prognosis, warning signs, and advise to remain active...
May 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28522629/transfusion-medicine-and-blood-banking-practices-manual-of-veterinary-transfusion-medicine-and-blood-banking
#10
Wendy Barnett
No abstract text is available yet for this article.
May 20, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28522145/wnt-signaling-a-novel-pathway-regulating-blood-pressure-state-of-the-art-review
#11
REVIEW
Maen D Abou Ziki, Arya Mani
Recent antihypertensive trials show conflicting results on blood pressure (BP) targets in patient populations with different metabolic profiles, with lowest benefit from tight BP control observed in patients with type 2 diabetes mellitus. This paradox could arise from the heterogeneity of study populations and underscores the importance of precision medicine initiatives towards understanding and treating hypertension. Wnt signaling pathways and genetic variations in its signaling peptides have been recently associated with metabolic syndrome, hypertension and diabetes, generating a breakthrough for advancement of precision medicine in the field of hypertension...
May 4, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28512119/complementary-and-integrative-medicine-in-the-management-of-headache
#12
REVIEW
Denise Millstine, Christina Y Chen, Brent Bauer
Headaches, including primary headaches such as migraine and tension-type headache, are a common clinical problem. Complementary and integrative medicine (CIM), formerly known as complementary and alternative medicine (CAM), uses evidence informed modalities to assist in the health and healing of patients. CIM commonly includes the use of nutrition, movement practices, manual therapy, traditional Chinese medicine, and mind-body strategies. This review summarizes the literature on the use of CIM for primary headache and is based on five meta-analyses, seven systematic reviews, and 34 randomized controlled trials (RCTs)...
May 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28505161/effect-on-healthcare-utilization-and-costs-of-spinal-manual-therapy-for-acute-low-back-pain-in-routine-care-a-propensity-score-matched-cohort-study
#13
Jochen Walker, Ulf Kai Mertens, Carsten Oliver Schmidt, Jean-François Chenot
Spinal manual therapy (SMT) is a popular treatment option for low back pain (LBP). The aim of our analysis was to evaluate the effects of manual therapy delivered by general practitioners and ambulatory orthopedic surgeons in routine care on follow up consultations, sick leave, health service utilization and costs for acute LBP compared to matched patients not receiving manual therapy. This is a propensity score matched cohort study based on health claims data. We identified a total of 113.652 adult patients with acute LBP and no coded red flags of whom 21...
2017: PloS One
https://www.readbyqxmd.com/read/28503317/diagnostic-accuracy-of-single-channel-cystometry-for-neurogenic-bladder-diagnosis-following-spinal-cord-injury-a-pilot-study
#14
Akmal Hafizah Zamli, Kavitha Ratnalingam, Yusma Asni Yusmido, Kuo Ghee Ong
INTRODUCTION: This is a cross-sectional study of 1 year duration (August 2013 to August 2014). The objective of the study was to investigate the diagnostic accuracy of single channel cystometry (SCC) for confirmation of neurogenic bladder following spinal cord injury. MATERIALS AND METHODS: The study was conducted in both out-patient and in-patient services of Department of Rehabilitation Medicine, Hospital Sungai Buloh, Malaysia. Subjects in the study include sixteen patients with a clinical diagnosis of neurogenic bladder following spinal cord injury aged between 15 and 62 years...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28499990/a-state-space-and-density-estimation-framework-for-sleep-staging-in-obstructive-sleep-apnea
#15
Dae Y Kang, Pamela N DeYoung, Atul Malhotra, Robert L Owens, Todd P Coleman
OBJECTIVE: Although the importance of sleep is increasingly recognized, the lack of robust and efficient algorithms hinders scalable sleep assessment in healthy persons and those with sleep disorders. Polysomnography (PSG) and visual/manual scoring remain the gold standard in sleep evaluation, but more efficient/automated systems are needed. Most previous works have demonstrated algorithms in high agreement with the gold standard in healthy/normal (HN) individuals - not those with sleep disorders...
May 8, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28497643/three-dimensional-ultrashort-echo-time-mri-and-short-t2-images-generated-from-subtraction-for-determination-of-tumor-burden-in-lung-cancer-preclinical-investigation-in-transgenic-mice
#16
Andreas Müller, Philippe Jagoda, Peter Fries, Stefan Gräber, Robert Bals, Arno Buecker, Christopher Jungnickel, Christoph Beisswenger
PURPOSE: To investigate the potential of 3D ultrashort echo time MRI and short T2 images generated by subtraction for determination of total tumor burden in lung cancer. METHODS: As an animal model of spontaneously developing non-small cell lung cancer, the K-rasLA1 transgenic mouse was used. Three-dimensional MR imaging was performed with radial k-space acquisition and echo times of 20 µs and 1 ms. For investigation of the short T2 component in the recorded signal, subtraction images were generated from these data sets and used for consensus identification of tumors...
May 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28494847/history-of-cupping-hijama-a-narrative-review-of-literature
#17
REVIEW
Naseem Akhtar Qureshi, Gazzaffi Ibrahim Ali, Tamer Shaban Abushanab, Ahmed Tawfik El-Olemy, Meshari Saleh Alqaed, Ibrahim S El-Subai, Abdullah M N Al-Bedah
Cupping (Hijama in Arabic) is an ancient, holistic method for the treatment of a variety of diseases. Though the exact origin of cupping therapy is a matter of controversy, its use has been documented in early Egyptian and Chinese medical practices. Diverse human civilizations have contributed to the historical development and continuation of cupping therapy. This narrative review describes the history of cupping, historical definitions, cupping instruments and uses of cupping therapy. Electronic searches of relevant databases (PubMed, Google Scholar and OvidSP) were conducted using keywords and Boolean operators...
May 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28494090/transconvolution-based-equalization-of-positron-energy-effects-for-the-use-of-68-ge-68-ga-phantoms-in-determining-18-f-pet-recovery
#18
George A Prenosil, Michael Hentschel, Markus Fürstner, Thomas Krause, Thilo Weitzel, Bernd Klaeser
PURPOSE: Avoiding measurement variability from (18) F phantom preparation by using (68) Ge/(68) Ga phantoms for the determination of (18) F recovery curves (RC) in clinical quality assurance measurements and for PET/CT site qualification in multicentre clinical trials. METHODS: RCs were obtained from PET/CT measurements of seven differently sized phantom spheres filled either with (18) F or with (68) Ga. RCs for the respective other isotope were then determined by two different methods: In the first method, images were convolved with positron range transconvolution functions derived from positron annihilation distributions found in literature...
May 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28493287/soft-tissue-sarcoma-nomograms-and-their-incorporation-into-practice
#19
REVIEW
Dario Callegaro, Rosalba Miceli, Luigi Mariani, Chandrajit P Raut, Alessandro Gronchi
The accurate prediction of prognosis in patients with soft tissue sarcoma (STS) is a challenging issue. Extreme variability in the clinical and pathological characteristics of this family of tumors hinders the simple stratification of patients into meaningful prognostic cohorts. Precision medicine tools for the prediction of prognosis, such as nomograms, enable personalized computation of outcome based on clinical and pathological characteristics of both patient and tumor. The eighth edition of the American Joint Committee on Cancer staging manual moved from a "population-based" to a "personalized" approach endorsing high-quality nomograms to improve clinician prediction ability in definite patient subgroups...
May 10, 2017: Cancer
https://www.readbyqxmd.com/read/28490744/precision-radiology-predicting-longevity-using-feature-engineering-and-deep-learning-methods-in-a-radiomics-framework
#20
Luke Oakden-Rayner, Gustavo Carneiro, Taryn Bessen, Jacinto C Nascimento, Andrew P Bradley, Lyle J Palmer
Precision medicine approaches rely on obtaining precise knowledge of the true state of health of an individual patient, which results from a combination of their genetic risks and environmental exposures. This approach is currently limited by the lack of effective and efficient non-invasive medical tests to define the full range of phenotypic variation associated with individual health. Such knowledge is critical for improved early intervention, for better treatment decisions, and for ameliorating the steadily worsening epidemic of chronic disease...
May 10, 2017: Scientific Reports
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